CN101411798A - Chinese medicine preparation for treating schizophrenia - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for treating schizophrenia, which is prepared from the following raw materials in weight portion: 6 to 12 portions of angelica, 8 to 12 portions of radix paeoniae alba, 6 to 10 portions of radix bupleuri, 6 to 10 portions of poria alba, 6 to 12 portions of ageratum, 5 to 10 portions of raw liquorice, 2 to 5 portions of green tangerine orange peel, 2 to 5 portions of radix gentianae, 4 to 8 portions of fructus trichosanthis, 6 to 10 portions of cyperus rotundus linn, 8 to 12 portions of herba lycopodli, 8 to 12 portions of mimosa and 4 to 7 portions of rhubarb. The traditional Chinese medicine preparation can be prepared into oral liquid, pills or capsules; when a patient, under the guidance of a doctor, takes the traditional Chinese medicine preparation, adds or reduce the amount of the traditional Chinese medicine preparation according to the condition of the patient and is matched with medicine treatment, the effective rate is 98 percent, the recurrence rate is 8 percent, and the healing rate reaches 85 percent. The traditional Chinese medicine preparation is a pure traditional Chinese medicine preparation, has no toxic side effect and low price, thereby greatly reducing the economic burden of the patient and bringing good social and economic benefits.

Description

The schizoid Chinese medicine preparation of a kind of treatment

Technical field

The present invention relates to a kind of Chinese medicine preparation, the concrete schizoid Chinese medicine preparation of a kind of special for treating that relates to.

Background technology

At present, whole world spiritedness patient is about 1.2 hundred million, owing to there is not good treatment way, new mental patient is constantly taken place again, because social various contradictions constantly intensify, psychotic sickness rate is in rising trend again.

The psychiatric treatment in the whole world is western medical treatment, and method has: insulin shock therapy, electric shock treatment, and antipsychotic drug treatment.Wherein antipsychotic drug is the most commonly used, and as: chlorpromazine, tranquilizer such as stable, above-mentioned agents alleviate symptom is very fast, but late result is undesirable, often outbreak repeatedly, and side effect is serious, can only take stopgap measures, and can not effect a permanent cure.

The treatment by Chinese herbs psychosis is mainly carried out in that China is domestic, and method is a lot, but the outstanding person of curative effect is few, and cure rate is not high.Also have some Chinese physicians to apply for---treat the psychosis patent, the opinion of oneself has been described.But the Chinese medicine extensive knowledge and profound scholarship, many traditional Chinese medical science scholars according to the clinical experience of oneself, inherit the tradition of Chinese medicine, create the prescription that makes new advances, preparation.But that widelys popularize in the industry is less, as Chinese patent application number is (200410026239.2), patent name is " treating simple epilepsy and psychotic Chinese medicine ", application number is (02135842.7), patent name is " a kind of antipsychotic Chinese medicine ", application number is (98113989.2), and patent name is not all gaining universal acceptance aspect the psychosis for " the psychotic Chinese medicine of a kind of treatment all kinds---have one's ideas straightened out relax refreshing capsule " waits treating, and widelys popularize.

Psychosis produces reason (cause of disease) because of pernicious exciter, accounts for 85%, and heredity accounts for 6%, and other account for 9%.Some psychosiss produce immediate cause or characterize the cause of disease and can determine, but, the actual cause of disease of each case or combined influence mechanism can't be said clear veritably so far, but observe from Chinese medicine angle clinical treatment process, find that the following factors that occurs with patient body is relevant: interior-heat is flourishing, autointoxication, stagnated phlegm is long-pending for a long time, and body function descends.In general be: direct stimulation, personality defective, scaring factor, inherited genetic factors.

Schizophrenia by traditional Chinese medical science typing, mainly is divided into two big classes: mad disease and epilepsy; Mad disease accounts for 90%, and epilepsy accounts for 10%;

For the mechanism process of psychosis morbidity, the row formula is as follows:

Mad disease pathology: rage impairing liver → stagnation of QI do not declare → strongly fragrant and fire-transformation → endure Tianjin become on expectorant → liver and gall QI rising in reverse order → phlegm-fire to disturb → thinking covered → brain is that the Seedling → mind of the heart is disorderly contrary and sick.

At present, general Chinese medicine is to psychotic Therapeutic Method: the clearing away heat-fire method, and the surreptitiously method of eliminating the phlegm out, the nourishing blood to tranquillize the mind method, the nourishing YIN for suppressing the hyperactive YANG method is reconciled regulating Qi activity of spleen.

Summary of the invention

The objective of the invention is, provide a kind of specific, specially control the pure Chinese medicinal preparation of " schizophrenia ", require the effective percentage height, relapse rate is low, makes that treatment can reach healing to most patients through this Chinese medicine preparation.Through inventor's clinical treatment and research for many years, finished this work.What this Chinese medicine preparation was invented is to study at mad disease treatment, does not carry out at epilepsy treatment research.

In the Chinese medicine preparation of the present invention, adopt the property of medicine of medicine, effect cures mainly and is respectively:

Radix Angelicae Sinensis: another name, in return, beg on the mountain, Wen Wu etc.Root for umbelliferae angelica.Nature and flavor: Gan Xin, temperature.Function cures mainly: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation.It is poly-etc. to control menoxenia, amenorrhea stomachache, dryness of the intestine dyschezia, mass in the abdomen knot.P876。

Radix Paeoniae Alba has another name called the Radix Paeoniae Alba, Radix Paeoniae Alba gold, Radix Paeoniae.(Paeonia lactiflora) is the root of cohosh Radix Paeoniae (cultigen).Nature and flavor: picric acid, cold.Function cures mainly: the energy nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing are received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia etc.P706。

Radix Bupleuri: different name, ground is smoked, and Asia puecon is recklessly.Be the samphire Radix Bupleuri, the root of Radix Bupeuri Scorzonerfolii. etc.Nature and flavor: bitter, cool.Effect cures mainly; Reconciling superficies and interior, expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Control shaoyang disease, stagnation of QI due to depression of the liver, collapse of QI, chronic diarrhea proctoptosis, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.P1832。

Poria:different name, Poria, Fu .Dry sclerotia for Polyporaceae plant Poria.Nature and flavor:sweet light, flat.Function cures mainly:promoting diuresis to eliminate damp pathogen, spleen invigorating invigorating middle warmer, mind tranquilizing and the heart calming.It is swollen to harness the river, and has loose bowels, insufficiency of the spleen, cardiopalmus, and insomnia, forgetful.

Herba Pogostemonis: (Agastache rugosa) nature and flavor: hot, tepor.Function cures mainly: removing dampness by means of aromatics and middle preventing or arresting vomiting, dispelling exopathogens from superficies of the body.Control retention of dampness in middle-JIAO, heat-damp in summer and hygropyrexia, vomiting.P2555。

Radix Glycyrrhizae: have another name called MEICAO, Herba Hedyotis cantonensis etc., be the root or the root stock of glycyrrhizic legume.Nature and flavor: sweet, flat.Function cures mainly: with middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Moxibustion usefulness is controlled weakness of the spleen and stomach, lack of appetite stomachache loose stool, consumptive lung disease cough, cardiopalmus etc.; Give birth to and use: control laryngopharynx swelling and pain, peptic ulcer is separated poison of drug and alimentary toxicosis.P567。

Pericarpium Citri Reticulatae Viride: different name, blue or green Pericarpium Citri tangerinae, blue or green Citrus chachiensis Hort. C. Suavissima Tanaka.Immature peel or young fruit for multiple Fructus Citri tangerinae classes such as rutaceae tangerines produced in fujian province.Nature and flavor: bitter, hot, warm.Function cures mainly: soothing the liver dispelling the stagnated QI, removing food stagnancyization stagnate.The treating the liver stagnation of QI stagnates, breast side of body gastralgia, stagnation of QI due to dyspepsia etc.P1224。

Radix Gentianae: be Radix Gentianae section plant three flower Radix Gentianae or Radix Gentianae rhizome.Nature and flavor: bitter, cold.Function cures mainly: eliminating pathogen in the liver gallbladder excess-fire, remove damp-heat in lower-JIAO.Treating the liver is mad dry through intenseness of heat ， Jing Epilepsy, encephalitis B etc.P627。

Fructus Trichosanthis, different name, fruit is naked, wild Fructus Momordicae charantiae, Fructus Trichosanthis.Fruit for the cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: sweet, cold.Effect cures mainly: fruit-rind of Chinese trichosanthes removing heat from the lung and dissipating phlegm.Control that the expectorant heat syndrome cough is breathed heavily, blocked-up chest, the thoracic obstruction, interior external carbuncle, dryness of the intestine constipation.P1780。

Rhizoma Cyperi: different name, passeris montani saturati head perfume (or spice), Rhizoma Cyperi.Be sedge dried tuber rhizome.Nature and flavor: hot, little hardship, flat.Effect cures mainly: liver-smoothing, qi-regulating, menstruction regulating and pain relieving.The treating the liver discomfort in the stomach, irritability stasis, stagnation of liver-QI menoxenia, dysmenorrhea, distending pain of the breast.P1672。

Herba Lycopodii: different name, Lycopodium clavatum, Cortex Ampelopsis Aconitifoliae Radicis, Lycopodium casuarinoides Spring etc.Whole herb with root for lycopsid.Nature and flavor: toil, temperature, nontoxic.Function cures mainly: expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Control anemofrigid-damp arthralgia, arthralgia skin numbness, tetraparesis, traumatic injury.1138。

Herba Mimosae Pudicae: different name, know shy grass, drink and exhale grass.Herb for the leguminous plant Herba Mimosae Pudicae.Nature and flavor: sweet, cold, poisonous.Effect: clearing away heat and promoting diuresis, preventing phlegm from forming and stopping coughing, ataralgesia, detoxifcation, dissipating blood stasis, hemostasis, convergence.Cure mainly: infantile hyperpyrexia, acute conjunctivitis, bronchitis, gastritis, enteritis, neurasthenia, treating swelling and pain by traumatic injury.P1148。

Radix Et Rhizoma Rhei: another name, yellow good, fire ginseng, general, continuous stricture of vagina Radix Et Rhizoma Rhei.Be polygonum rheum palmatum, Rheum tanguticum or Rheum officinale rhizome.Nature and flavor: bitter, cold.Function cures mainly: the poison that purges heat, removing mass stagnates, blood stasis expelling blood.The constipation of smelting excess-heat, food stagnation feeling of fullness, gastrointestinal retention, pyretic toxicity carbuncle sore, blood stasis disease, damp and hot yellow cellulitis.P102。

Illustrate: their contained page numbers in " Chinese medicine voluminous dictionary " version (Shanghai publishing house) in 1985 book of the page number that wherein every herbal medicine detail file indicates later number expression are the related content of therefrom taking passages above.

In the Chinese medicine preparation of the present invention, adopted following solution:

The schizoid Chinese medicine preparation of a kind of treatment of the present invention is to be made by following raw materials in weight portion:

Radix Angelicae Sinensis 6～12 Radix Paeoniae Alba 8～12 Radix Bupleuri 6～10 Porias 6～10 Herba Pogostemoniss 6～12 Radix Glycyrrhizae 5～10 Pericarpium Citri Reticulatae Virides 2～5 Radix Gentianaes 2～5 whole Fructus Trichosanthis 4～8 Rhizoma Cyperi 6～10 Herba Lycopodiis 8～12 Herba Mimosae Pudicaes 8～12 Radix Et Rhizoma Rhei 4～7 water 1600～1800; Compound method: according to the above ratio said medicine is prepared, add 1600～1800 parts in water then, 150～170 ℃ of heating-up temperatures, decoct twice, count 40 minutes for the first time when boiling, amount of water 1/2nd filters, and medicine is incorporated as the water yield 1/2nd then, 160～170 ℃ of heating-up temperatures decocted 40 minutes for the second time, filtered, merge medicinal liquid, 400～500 parts of simmer down tos in the packing medicine bottle, are made oral liquid.

The schizoid Chinese medicine preparation of a kind of treatment of the present invention, its each ingredients weight parts proportioning is:

Radix Angelicae Sinensis 10 Radix Paeoniae Alba 10 Radix Bupleuri 6 Porias 8 Herba Pogostemoniss 8

Radix Glycyrrhizae 6 Pericarpium Citri Reticulatae Virides 3 Radix Gentianaes 3 whole Fructus Trichosanthis 6 Rhizoma Cyperi 8

Herba Lycopodii 10 Herba Mimosae Pudicaes 10 Radix Et Rhizoma Rhei 5

The present invention is the schizoid Chinese medicine preparation of a kind of treatment, can be prepared into pill according to the pharmaceutics conventional method, or capsule.

The beneficial effect of Chinese medicine preparation of the present invention, patients undergo are treated its effective percentage 98%, relapse rate 8%, and specify: it is not fearful to recur, and controls first quarter moon again and still can cure, cure rate 85%.Because the present invention has no side effect for pure Chinese medicinal preparation, drug price is lower, reduces patient economy burden greatly, and good social effect and economic benefit are arranged.

Decoction, every dose of 500ml, every day, potion divided four times, and obey one hour ante cibum, and seven doses is a course of treatment.Its therapeutic process add decrement, need under physician guidance, take, the length course of treatment that treatment is adopted, the doctor that also needs to diagnose a disease is according to the ill weight of patient, the length of sick time is added and subtracted with disease.

Criterion of cure: drug withdrawal at once after heal (1), banning drugs do not stay the psychosis disease throughout one's life, and this cries: clinical cure.

(2) through after the spring in 1 year, the ill person of the disease that still is a cup too low just cries healing, and keeping promptly is thorough healing.

Embodiment

Embodiment:, take by weighing the decoction that each raw material makes the mad disease of treatment by following formula proportion:

Radix Angelicae Sinensis 10g Radix Paeoniae Alba 10g Radix Bupleuri 6g Poria 8g Herba Pogostemonis 8g

Radix Glycyrrhizae 6g Pericarpium Citri Reticulatae Viride 3g Radix Gentianae 3g whole Fructus Trichosanthis 6g Rhizoma Cyperi 8g

1800 milliliters in Herba Lycopodii 10g Herba Mimosae Pudicae 10g Radix Et Rhizoma Rhei 5g water

The decoction preparation method is: in proportion said medicine is added 1600～1800 parts in water, 150～170 ℃ of heating-up temperatures decoct twice, count when boiling, 40 minutes for the first time, amount of water 1/2nd, filter, medicine is incorporated as the water yield 1/2nd then, 160～170 ℃ of heating-up temperatures, decocted 40 minutes for the second time, and filtered, merge medicinal liquid, 500 milliliters of medicinal liquids of simmer down to, make oral liquid, be packed as 4 bottles, every bottle of 125ml.

Instructions of taking: warm water delivery service, every day potion, 4 bottles of potions.One natural gift are taken for four times, and obey one hour ante cibum, and seven days is a course of treatment.Or follow the doctor's advice and take.

Capsule preparation method thereof is: in proportion said medicine is pulverized, must cross 80～120 mesh sieves medicated powder, stir, add conventional pill filler in the medicated powder, they are made pill; Or medicated powder is divided in 12 capsules, obtain capsule.The capsule instructions of taking: warm water delivery service, every day potion, 12 of potions.Patient's one natural gift are taken for four times, and each 3, obey one hour ante cibum, and seven days is a course of treatment.It is one day dosage that the potion bolus quantities is divided into 12 parts.Or follow the doctor's advice and take.

[schizophrenia case]

Example 1: Mrs Qiao, 23 years old, Thailander U.S. music university reading 4 years, came the hospitalize of Xiamen garrison command on May 5th, 1993.Patient profile: premorbid personality is that comparison is optimistic export-oriented.Morbidity process: because of failure in love morbidity 2 years, insomnia, to murmur to oneself, doubt others say her malicious remark, the time laugh at when crying, auditory hallucination is to there being the people to scold she, constipation.Prescription on individual diagnosis process: treated 1 year in the U.S., treat half a year, go back to Thailand and treat half a year, cure the doctor and all accuse it: must take medicine everyday to Germany.Drug withdrawal is difficult to cure just repeatedly in the treatment.Physical examination situation when going to a doctor: yellowish complexion is simple and unadorned, have a dull expression on one's face, slow in reacting, question and answer are irrelevant to the subject, oneself can not explain the state of an illness.Deep-thready pulse string, red tongue, yellow fur are thick, examine to be schizophrenia, belong to the blood deficiency type of phlegm fire.

The Therapeutic Method of being taked: use Chinese medicine preparation of the present invention, treated for three courses of treatment, patient obtains curing.Practical situation was not seen recurrence so far in 15 years, and annual patient and family members call and pay a New Year call the Spring Festival, and all are normal.

Specify: Chinese medicine is silly, military silly to literary composition.Its pulse condition, picture of the tongue, symptom are respectively arranged, and the rule of treatment etc. are clocklike, and it is more to heal the sick, and each case is all carefully stated too and repeated, and the present is listed several typical cases again, and the situation of diagnosis and treatment is described.

Example 2; Lee * clean, woman, 12 years old, people from Guiyang, schizophrenia suddenly.In family's medical history: its uncle also is a schizophrenia.Patient morbidity through western medical treatment, has Western medicine and had a surplus in 1 year, from dare not drug withdrawal, recurs again to spring, during morbidity, hits and swears at people and stings the people ... the traditional Chinese medical science is had a medical check-up: arteries and veins, big vast number, knot, generation; Red tongue, the tongue sallow is thick. and flushing red; See it: be on tenterhooks. glaring eyes are looked mutually and are asked it: there's no one who doesn't or isn't make a sound.Through diagnoses and treatment, use Chinese medicine preparation of the present invention, through two courses of treatment of treatment, patient obtains recovery from illness, from 25 years so far nineteen eighty-three, never falls ill, and follow up a case by regular visits to every year, and all are normal.

Example 3: teacher Liu, man, 53 years old, Dafang County, Guizhou teacher.Suffered from schizophrenia 14 years, and can not work, have Western medicine everyday, the time heavy when light.

Its primary symptom: soliloquy, laugh secretly without reason, wash one's hands repeatedly, close door and window repeatedly, refreshing slow-witted, to seem lost in thought, idol has to swear at people pounds the act of thing.The yellowish complexion of sight is simple and unadorned, light red tongue sharp red, tongue is grey thick, its arteries and veins, heavy, thin, a little less than.Disease belongs to: the hematasthenic phlegm wet type.The rule of treatment; Use this Chinese medicine preparation, obtained recovery from illness in 65 days through treatment, annual New Year phone calls in the Spring Festival, all are normal.From 1987 21 years so far, do not see recurrence.

Example 4: Mrs Wang, 33 years old, unmarried, the Malaysian.In Britain's medical college graduation, to come back home later six months, schizophrenia appears, diagnosis: do not have obvious inducement, the Inheritance history is arranged, in Britain's treatment treatment half a year effectively, no disease symptom, but require patient to take medicine everyday, fell ill again to 1 year spring, treat half a year so forward Japan to, the state of an illness alleviates, patient is emotionally stable, in order to effect a radical cure illness, family members please many experts carry out diagnosis and treatment, all say and can't effect a radical cure, must take medicine everyday, ill 8 years of this patient can not work, and more can not marry, because of father and mother are rich merchants, see the doctor for treatment in long-term various places.

Patient symptom during to the court diagnosis and treatment: confusion of thinking, being happy and angry uncertainly, the time moving when quiet, irregular, apathetic expression, pallor is simple and unadorned, the light red tongue point is red, tongue white lime and greasy, stringy pulse, a little less than.Disease belongs to the hematasthenic phlegm pattern of fever, and in the diagnosis, doctor trained in Western medicine thinks that its disease shows as " mixed type " everywhere.

The court's treatment:, treat recovery from illness in 51 days through Chinese medicine preparation of the present invention.From 1994 14 years so far, do not see recurrence, annual New Year phone calls in the Spring Festival, all are normal.

Other cure case:

Example 5, Lee * lotus, the age: 30, sex: the woman, the sick kind: the feign madness genotype of smart branch, sick time: 5 years, treatment time: the moon was surplus.Address: railroad suboffice room, the Kweiyang section of building.

Example 6, ten thousand * sweet smell, the age: 28, sex: the woman, the sick kind: smart branch is feign madness, sick time: 1 year, treatment time: first quarter moon.Address: Kweiyang steel plant.

Example 7, king * clean, the age: 25, sex: the woman, the sick kind: smart branch is feign madness, sick time: 1 year, treatment time: January, address: Guan Ling county cadre.

Example 8, Fan * red, the age: 24, sex: the woman, the sick kind: smart branch is feign madness, sick time: 1 year half, treatment time: January, address: Suiyang County cadre.

Example 9, open * lotus the age: 52, sex: the woman, the sick kind: smart divide feign madness, sick time: 5 years, treatment time: 18 days, address: Taiyuan City rolling stock section.

Example 10, Liu * jade, the age: 22, sex: the woman, the sick kind: smart branch is feign madness, sick time: half a year, treatment time: the moon is surplus, address: Harbin Electric Machinery Plant.

Example 11, Lee * red, the age: 27, sex: the woman, the sick kind: smart branch is feign madness, sick time: 4 years, treatment time: the bimester, address: town Ning County committee.

Example 12, river *, the age: 16, sex: the man, the sick kind: smart divide feign madness, sick time: 4 months, treatment time: month surplus, address: six.

Example 13, Deng *, the age: 30, sex: the woman, the sick kind: smart divide feign madness, sick time: 1 month, treatment time: first quarter moon, address: Pan county.

Since 1967, cured example surplus the external patient 150, example surplus in the of domestic 400.Healing person, drug withdrawal at once after healing, no longer repeatedly.Observe more back patient, will wait until after 1 year spring still do not have ill person at least, be radical cure; Adopt Chinese medicine preparation of the present invention to be, to concrete patient, the dose plus-minus is carried out in state of an illness diagnosis in conjunction with the doctor, and cure rate is generally more than 85%.

Claims (3)

1, the schizoid Chinese medicine preparation of a kind of treatment is characterized in that being made by following raw materials in weight portion:

Radix Angelicae Sinensis 6～12 Radix Paeoniae Alba 8～12 Radix Bupleuri 6～10 Porias 6～10 Herba Pogostemoniss 6～12 Radix Glycyrrhizae 5～10 Pericarpium Citri Reticulatae Virides 2～5 Radix Gentianaes 2～5 whole Fructus Trichosanthis 4～8 Rhizoma Cyperi 6～10 Herba Lycopodiis 8～12 Herba Mimosae Pudicaes 8～12 Radix Et Rhizoma Rhei 4～7 water 1600～1800; Compound method: according to the above ratio said medicine is prepared, add 1600～1800 parts in water then, 150～170 ℃ of heating-up temperatures, decoct twice, 40 minutes for the first time, amount of water 1/2nd, filter, medicine is incorporated as the water yield 1/2nd then, 160～170 ℃ of heating-up temperatures, decocted 40 minutes for the second time, filter, merge medicinal liquid, 400～500 parts of simmer down tos, in the packing medicine bottle, make oral liquid.

2, the schizoid Chinese medicine preparation of a kind of treatment according to claim 1 is characterized in that its each ingredients weight parts proportioning is:

Radix Angelicae Sinensis 10 Radix Paeoniae Alba 10 Radix Bupleuri 6 Porias 8 Herba Pogostemoniss 8

Radix Glycyrrhizae 6 Pericarpium Citri Reticulatae Virides 3 Radix Gentianaes 3 whole Fructus Trichosanthis 6 Rhizoma Cyperi 8

Herba Lycopodii 10 Herba Mimosae Pudicaes 10 Radix Et Rhizoma Rhei 5.

3, the schizoid Chinese medicine preparation of a kind of treatment according to claim 1 is prepared into pill according to the pharmaceutics conventional method, or capsule.