CN102198178B - Traditional Chinese medicine capsule for treating insomnia, amnesia, insufficient blood supply, and the like - Google Patents
Traditional Chinese medicine capsule for treating insomnia, amnesia, insufficient blood supply, and the like Download PDFInfo
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- CN102198178B CN102198178B CN2011101350719A CN201110135071A CN102198178B CN 102198178 B CN102198178 B CN 102198178B CN 2011101350719 A CN2011101350719 A CN 2011101350719A CN 201110135071 A CN201110135071 A CN 201110135071A CN 102198178 B CN102198178 B CN 102198178B
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Abstract
The invention relates to traditional Chinese medicine capsules capable of treating the symptoms of insufficiency of cerebral blood supply, memory decline, cerebral apoplexy sequela, brain functional degradation, encephalatrophy, insomnia and the like. The traditional Chinese medicine capsules comprise the following components in parts by weight: 12-30 parts of cistanche deserticola, 16-30 parts of red sage root, 1-3 parts of pearl, 3-6 parts of liquorice, 5-12 parts of wild jujube seed and 3-9 parts of magnolia vine fruit. The invention also provides a preparation method of the traditional Chinese medicine capsules.
Description
Technical field
The present invention relates to a kind of cerebral blood supply insufficiency, hypomnesis, cerebral apoplexy sequela for the treatment of, the Chinese medicinal capsule of the symptoms such as brain function decline, brain atrophy, insomnia.
Background technology
21 century aged tendency of population and Senile disease brought stern challenge to us.Impel us again to think deeply old people's the health care issues such as health, disease.Follow hard on aged tendency of population, the sickness rate of Senile disease also straight line rises, such as alzheimer disease, senile encephalatrophy, hypomnesis etc.The characteristics of geratic period disease are: how sick 1 one people are, 2 atypical symptoms, 3 development are fast, easy multiple organs failure, 4 complication are many, 5 Drug tolerances are poor, 6 be subject at heart, the Nervous and Mental Factors impact, and exactly the current Western medicine of these characteristics and Chinese medicine is only to some symptoms effectively and other symptom is invalid, and the shortcomings such as side effect is large are difficult to play satisfied curative effect, because their inevitable side effect easily causes the property infringement of medicine source, it is little therefore to develop side effect, is suitable for old people's physiology and is the subject matter that modern medicine faces to the active drug of Senile disease.
Summary of the invention
A kind of Chinese medicinal capsule provided by the invention is by the synthetic pharmaceutical composition of six kinds of famous and precious mongolian medicines such as Herba Cistanches, Radix Salviae Miltiorrhizae, Margarita, Radix Glycyrrhizae, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis.Wherein:
Herba Cistanches: have desert Radix Ginseng good reputation, because containing the similar active substance of nerve growth factor, and contain 2-caproyl eugenol glycoside, daucosterol and 15 seed amino acids all are the necessary nutrient substance of brain cell, and have the neuroprotective function.The herba cistanches pharmaceutical research thinks that it contains Herba Cistanches element glycosides A, and B....G contains D-MANNOSE, β-glutamic acid, amber primary acid, Alkaloid.Think that from pharmacological research Herba Cistanches has: 1, strengthen immunologic function; 2, resisting fatigue, antioxidation, defying age, cold-resistant; 3, protection cardiac-cerebral ischemia; 4 brain-strengthening, the functions such as the kidney invigorating.Mongolian medicine's theory is thought: alzheimer disease belongs to deficient syndrome more, and particularly heart kidney deficiency of spleen-QI, so Mongolian medicine theory is thought main kidney tonifying marrow facilitating, the reinforcing the heart spleen of holding concurrently.There is research to think that Herba Cistanches contains benzene hexanol glycosides compound, has the anti-senile dementia effect.
Radix Salviae Miltiorrhizae: be the root of labiate Radix Salviae Miltiorrhizae.1 chemical constituent main contains liposoluble constituent, comprise Tanshinone I, Tanshinone I I A, Tanshinone II B, Tanshinone I II ....Water soluble ingredient mainly contains danshensu, saivianic acid A, second, third.2, pharmacological action: can expand cardiovascular and cerebrovascular vessel, improve hypoxia endurance, improve hemorheology, blood viscosity lowering, anticoagulant function.Especially Tanshinone I IA has protective effect to cerebral ischemia reperfusion injury, its mechanism may with reduce inflammatory reaction behind the ischemia-reperfusion, alleviate oxidative damage and to improve energy metabolism impairment relevant.There are some researches prove that TANSHINONES A can improve the learning and memory function of mice, can increase fourth ventricle in mice with vascular dementia cortex and hippocampus amino acid content, show very strong antioxidation.
Margarita: contain 18 seed amino acids, the chemical composition of Margarita is: CaCO391.6%, H2O and organic each 4%, glutamic acid 0.4%.Other aminoacid has: leucine (Leucine), methionine (Methionine), alanine (Alanine), glycine (Glycine), glutamic acid (Glutami cacid), aspartic acid (Aspartic acid) etc.In addition, these all are the important substance of protection brain cell and nutrition cerebral tissue also to contain 30 various trace elements, taurine, abundant vitamin, peptide class.Modern pharmacology research, the main component of Margarita has calcium carbonate, taurine, the trace element of needed by human body also contains the aminoacid of needed by human body.Its effect is as follows; Taurine; Effectively balance the body nervus centralis and endocrine help sleep.Glycine, the acid of Shen thiamine; Help delay senility, improve human endocrine, enhance metabolism, health invigorating.Margarita also contains various trace elements; Magnesium, aluminum, copper, ferrum, sodium, zinc, titanium, strontium, silver.Its glycine and alanine are maximum.
Radix Glycyrrhizae: main component: from Radix Glycyrrhizae, isolate at present more than 160 and plant Licorice flavanone compounds and 60 kinds of liquorice flavonoids compounds and legumin class, 18 seed amino acids, and multiple alkaloid, estrogen, and multiple organic acid.Pharmacological action: 1, antiinflammatory is one of Main Function of glycyrrhizic acid, and is inhibited to immune inflammation; 2, wherein a kind of chemical compound of flavonoid-different Radix Glycyrrhizae class has lax blood vessel, antioxidation, and anticoagulant, antiviral, antitumor and multiple pharmacological effect have protective effect to the hypoxic-ischemic of brain.
Semen Ziziphi Spinosae: chemical constituent mainly contains jujuboside A, B and flavone compound.Pharmacological action; Calmness, syngignoscism also has blood fat reducing, antiplatelet aggregation, lipoid peroxidization resistant.Experimental results show that; Semen Ziziphi Spinosae oil is cholesterol reducing obviously, low density lipoprotein, LDL and triglyceride level, the ratio of high density lipoprotein increasing and low-density lipoprotein cholesterol.Pharmacological research shows; Semen Ziziphi Spinosae can strengthen immunologic function, and its hexanol extract strengthens the phagocytic function of mononuclear phagocyte.Strengthen delayed hypersensitivity and the energy antagonism CPA of mice, cause the inhibition of the delayed hypersensitivity of mice.Experimental results show that Semen Ziziphi Spinosae has protective effect to the cerebral ischemia infringement.
Fructus Schisandrae Chinensis: extracting solution has inhibitory action to brain SOD, and malonaldehyde (MDA) level can point out the protection cerebral tissue to the lipid peroxidation injury effect.Have obvious effect of scavenging radical and suppress lipid peroxidation through Fructus Schisandrae Chinensis and active ingredient such as schisandrin B SALLRSIPA SAL ADNF-9 schizronol schisanhenol etc., its mechanism of action can suppress the generation of oxygen-derived free radicals on the one hand, but other antagonism oxygen-derived free radicals.
The hypomnesis that a kind of Chinese medicinal capsule provided by the invention causes insomnia, forgetful, cerebral blood supply insufficiency, cerebral trauma, the symptoms such as brain function decline have good curative effect, and it is little to have consumption, absorb slowly, lasting medicine, curative effect is high, and side effect is little, takes the characteristics that are suitable for the geratic period disease with grade easy to carry.
It is (by weight) that components compatibility in a kind of Chinese medicinal capsule of the present invention closes: Herba Cistanches 12-30, Radix Salviae Miltiorrhizae 6-30, Margarita 1-3, Radix Glycyrrhizae 3-6, Semen Ziziphi Spinosae 5-12, Fructus Schisandrae Chinensis 3-9.
The compatibility relationship of the mongolian medicine composition in a kind of Chinese medicinal capsule of the present invention is preferably (by weight): Herba Cistanches 30, Radix Salviae Miltiorrhizae 30, Margarita 3, Radix Glycyrrhizae 6, Semen Ziziphi Spinosae 12, Fructus Schisandrae Chinensis 9.
A kind of Chinese medicinal capsule of the present invention can be made various pharmaceutical dosage forms according to method well known in the art, such as capsule, tablet, powder etc., and preferably, pharmaceutical composition of the present invention is a kind of capsule.
The preparation method of a kind of Chinese medicinal capsule of the present invention is to prepare raw material, drying according to described weight portion, be ground into fine powder, then use the lixiviate of water 3 hours of 8 times of amounts, obtain first-time filtrate, and then with the water secondary lixiviate of 10 times of amounts 2 hours, obtain secondary filtrate, merge filtrate twice, be concentrated into the thick paste of temperature 40-80 ℃ lower relative density 1.3-1.5, then dry in vacuum drying oven, be ground into fine powder, make at last capsule, powder or be pressed into tablet.
The specific embodiment
Embodiment 1
Prepare raw material, Herba Cistanches 12, Radix Salviae Miltiorrhizae 6, Margarita 3 by following weight portion, Radix Glycyrrhizae 3, Semen Ziziphi Spinosae 5, Fructus Schisandrae Chinensis 3, mix, drying is ground into fine powder, then use the lixiviate of water 3 hours of 8 times of amounts, obtain first-time filtrate, and then with the water secondary lixiviate of 10 times of amounts 2 hours, obtain secondary filtrate, merge filtrate twice, be concentrated into the thick paste of temperature 40-80 ℃ of lower relative density 1.3, then dry in vacuum drying oven, be ground into fine powder, make at last capsule.
Embodiment 2
Prepare raw material, Herba Cistanches 18, Radix Salviae Miltiorrhizae 12, Margarita 2 by following weight portion, Radix Glycyrrhizae 5, Semen Ziziphi Spinosae 10, Fructus Schisandrae Chinensis 4, mix, drying is ground into fine powder, then use the lixiviate of water 3 hours of 8 times of amounts, obtain first-time filtrate, and then with the water secondary lixiviate of 10 times of amounts 2 hours, obtain secondary filtrate, merge filtrate twice, be concentrated into the thick paste of temperature 40-80 ℃ of lower relative density 1.4, then dry in vacuum drying oven, be ground into fine powder, make at last capsule.
Embodiment 3
Prepare raw material, Herba Cistanches 30, Radix Salviae Miltiorrhizae 30, Margarita 3 by following weight portion, Radix Glycyrrhizae 6, Semen Ziziphi Spinosae 12, Fructus Schisandrae Chinensis 9, mix, drying is ground into fine powder, then use the lixiviate of water 3 hours of 8 times of amounts, obtain first-time filtrate, and then with the water secondary lixiviate of 10 times of amounts 2 hours, obtain secondary filtrate, merge filtrate twice, be concentrated into the thick paste of temperature 40-80 ℃ of lower relative density 1.5, then dry in vacuum drying oven, be ground into fine powder, make at last capsule.
Embodiment 4 (curative effect data)
Obtain product with the preferred component proportioning of capsule preparations of the present invention and carry out clinical examination, the 0.3g/ capsule, one time three, three times on the one, 30 days courses for the treatment of.This medicine is to shown in the following tabulation lattice of curative effect of various disease and each age group thereof: wherein said effectively, produce effects, healing, invalid standard be according to the Clinical Nerve Function Deficiency standards of grading: 1. cure: functional impairment scoring minimizing 91%-100%, disability degree is 0 grade, 2. produce effects: the functional impairment scoring reduces 46%-90%, disability degree is the 1-3 level, 3. effectively: the functional impairment scoring reduces 18%-45%, and is 4. invalid: the functional impairment scoring reduces less than 17% or increases or death.
1. the front patient for the treatment of has difficulty falling asleep, and often awakening is slept and shakiness, can not sleep again, and wake up too early morning, can not fall asleep night, and daytime, lethargic and drowsy state was not had enough sleep 5 hours, and history of repeated attack is arranged, and insomniac due to eliminating spirit and the severe organic disease.Clinical cure after the treatment: recover the length of one's sleep normal or Nighttime sleep more than 6 hours, sleep is dull, and is hale and hearty after waking up.Produce effects: sleep is clearly better, and has increased by 3 hours the length of one's sleep, and Depth of sleep increases.Effectively: sx↓, the length of one's sleep, front increase less than was 3 hours.Invalid: insomnia is without obviously improving or adding severe one after the treatment.
Table 1 couple insomniac's curative effect (totally 60 examples)
2. before the cerebral blood supply insufficiency patient treatment: dizzy, nauseating, vomiting, uncomfortable in chest, headache, numb limbs and tense tendons or acid are swollen, tinnitus etc.And the cranium Doppler ultrasound examination of passing through, vertebral artery bilateral blood supply insufficiency and carotid artery blood supply insufficiency are arranged.Cure after the treatment: above-mentioned symptom disappears and cranium Doppler ultrasound examination blood vessel recovers normal.Produce effects: above-mentioned symptom disappears substantially, but does not have recovery normal through the cranium Doppler ultrasound examination.Effectively: above-mentioned symptom alleviates, but does not disappear, and the cranium Doppler ultrasound examination of passing through is with before treating.Invalid: above-mentioned symptom does not alleviate or increases the weight of.Pass through the cranium Doppler ultrasound examination with before treating.
Table 2 couple cerebral blood supply insufficiency patient's curative effect (totally 52 examples)
3. the patient has mind clear before the treatment, and orientation force is poor, and memory (recent, long term) obviously goes down, and computing power is poor, bradykinesia; Cure after the treatment: patient's memory, orientation force, computing power etc. all recover normal.Produce effects: cardinal symptom disappears substantially, and is conscious, and orientation force is sound, and it is correct to answer a question, and is quick on the draw; Effectively: answering a question is in the main true, but bradykinesia, intelligence and memory still have partial impairment; Invalid: cardinal symptom is without changing or PD.
Table 3 couple forgetful patient's curative effect (totally 45 examples)
Model case
Wang Quanzhong, the man, 50 years old, difficulty falling asleep, often awakening is slept and shakiness, can not sleep again, does not have enough sleep 5 hours, and the medical history of repeatedly showing effect has 1 year, in outpatient clinic on February 5th, 2007.Give this medicine and be aided with essential drug and treat by upper method, recover normal the lengths of one's sleep after 2 weeks.
Wen Guizhen, woman, 76 years old; The peasant; Main cause is slow in action, more than 1 year outpatient clinic of hypomnesis.It is ineffective action to occur without obvious inducement before the patient more than 1 year, and hypomnesis was often looked for loseing house in nearly 1 month, and near, at a specified future date memory obviously goes down.Department of neurology is had a medical check-up: patient's sanity, memory, computing power, orientation force obviously go down.Outpatient service gives this medicine and is aided with essential drug and treats by upper method, and symptom is clearly better soundly to orientation force after 30 days, and it is correct to answer a question, and is quick on the draw.
Wang Meihua, the patient, the women, 69 years old, the retired worker, on May 7th, 2006 outpatient clinic.Before 3 days WA occur suddenly dizzy, depending on the thing rotation, aggravation when cervical region is movable, the nausea of feeling sick, discomfort uncomfortable in chest, the stiff pain of neck.Symptom is not alleviated after having a rest, and comes my institute's diagnosis and treatment.Cervical spondylosis is arranged, recurrent ventigo history 3 years.Body is looked into: blood pressure 18/12Kpa.The obvious tenderness of cervical vertebra.Rombergism is positive.Enlarged tongue, tongue are greasy in vain, stringy and rolling pulse.Blood biochemical investigation: T-CHOL 5.10mmol/L, triglyceride 1.99mmol/L.Cervical X-ray sheet: cervical spine degeneration.Transcranial doppler shows: cerebral arteriosclerosis, right side vertebral artery, right side anterior cerebral artery blood supply insufficiency.Diagnosis: vertebro-basilar artery insufficiency.Give this medicine and be aided with essential drug and treat by upper method, medication took a turn for the better in 3 days afterwards, had fully recovered in the time of 15 days.
Claims (3)
1. Chinese medicinal capsule, the crude drug that it is characterized in that making its active component is comprised of the component of following weight proportioning: Herba Cistanches 12-30, Radix Salviae Miltiorrhizae 6-30, Margarita 1-3, Radix Glycyrrhizae 3-6, Semen Ziziphi Spinosae 5-12, Fructus Schisandrae Chinensis 3-9.
2. according to claim 1 a kind of Chinese medicinal capsule, the crude drug of wherein making its active component is comprised of the component of following weight proportioning: Herba Cistanches 30, Radix Salviae Miltiorrhizae 30, Margarita 3, Radix Glycyrrhizae 6, Semen Ziziphi Spinosae 12, Fructus Schisandrae Chinensis 9.
3. the preparation method of arbitrary Chinese medicinal capsule is characterized in that preparing crude drug, drying according to described weight portion according to claim 1-2, be ground into fine powder, then use the lixiviate of water 3 hours of 8 times of amounts, obtain first-time filtrate, and then with the water secondary lixiviate of 10 times of amounts 2 hours, obtain secondary filtrate, merge filtrate twice, be concentrated into the thick paste of temperature 40-80 ℃ lower relative density 1.3-1.5, then dry in vacuum drying oven, be ground into fine powder, make at last capsule.
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| CN104873679A (en) * | 2012-02-01 | 2015-09-02 | 李庭栋 | A potato and cistanche-containing life-protecting decoction |
| CN111729040A (en) * | 2020-07-10 | 2020-10-02 | 孟凡云 | A teabag with sleep improving effect and its preparation method |
Citations (2)
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| CN101306156A (en) * | 2008-06-14 | 2008-11-19 | 王跃进 | Yixinfumai capsule |
| CN101757268A (en) * | 2008-11-08 | 2010-06-30 | 陈志锋 | Traditional Chinese medicine composite for treating Insomnia and lethargy and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306156A (en) * | 2008-06-14 | 2008-11-19 | 王跃进 | Yixinfumai capsule |
| CN101757268A (en) * | 2008-11-08 | 2010-06-30 | 陈志锋 | Traditional Chinese medicine composite for treating Insomnia and lethargy and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 胡怀强.近年中医药治疗中风后遗症进展.《河南中医学院学报》.2003,第18卷(第06期),83-85. * |
| 黄燕凤等.中医药治疗老年失眠症的临床研究进展.《辽宁中医药大学学报》.2009,第11卷(第02期),76-77. * |
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