CN1660218A - Chinese materia medica preparation for treating andropathy - Google Patents
Chinese materia medica preparation for treating andropathy Download PDFInfo
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- CN1660218A CN1660218A CN 200410073397 CN200410073397A CN1660218A CN 1660218 A CN1660218 A CN 1660218A CN 200410073397 CN200410073397 CN 200410073397 CN 200410073397 A CN200410073397 A CN 200410073397A CN 1660218 A CN1660218 A CN 1660218A
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Abstract
A Chinese medicine 'Sheshen capsule' for treating sexual hypofunction and impotence of man i sprepared from 7 Chinese-medicinal materials including epimedium, cnidium fruit, ginseng, cistanche, etc.
Description
Technical field: the present invention relates to a kind of Chinese medicine preparation for the treatment of andropathy, more specifically to a kind of SHESHEN collocystis for the treatment of male's sexual decline, sexual impotence.
Background technology: the middle age is the human body transitional period from prosperity to decline, and Ancient Times in China early has comparatively deep understanding to this." Nian Sishi and half of YIN QI consumed also, decline of vitality in daily life ", " seven or eight Radix Semiaquilegiaes of woman seventy-seven men exhaust " indicates that promptly human body progressively enters the geratic period thus.According to Kinsey, the generative capacity of mankind spermatozoon descended later on since 30 years old, and testicular weight slowly descended since 40 years old, and the volume of testis dwindled later on since 50 years old, and the hardness of testis is hardening gradually since 60 years old.Smith thinks, human sexual function changes the arterial occlusion with seminiferous tubule, and the excretory inhibin of stromal cell increases, cause the short gonad axis of hypophysis not normal due to.So people's life process is clocklike, the sexual activity ability increases along with the age and goes down.Drug action is bad, and bioavailability is low, has untoward reaction more or less, as NANBAO JIAONANG.
Summary of the invention: the purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of andropathy, it has " the kidney invigorating warming YANG; the effect of invigorating spleen and nourishing heart; it is made up of multiple medical material; be used for the treatment of soreness of the waist and knees, aversion to cold and cold limbs that male's sexual decline etc. causes; spiritlessness and weakness, symptoms such as nocturia have the improvement effect.
Technical scheme of the present invention is: design a kind of Chinese medicine preparation for the treatment of andropathy, it is characterized in that: its main component comprises Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Herba Cistanches 1%-75%.
Described composition comprises Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Fructus Rubi 1.5%-80%, Herba Cistanches 1%-75%, Fructus Lycii 1%-75%.
Described composition includes: Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Fructus Rubi 1.5%-80%, Herba Cistanches 1%-75%, Fructus Lycii 1%-75%, Radix Glycyrrhizae 0.1-50%, Radix Morindae Officinalis 0.1%-50%.
Described composition has: Herba Epimedii 1000g, Fructus Cnidii 800g, Radix Ginseng 40g, Rhizoma Curculiginis 400g, Fructus Rubi 800g, Herba Cistanches 400g, Fructus Lycii 400g.
Described composition has: Herba Epimedii 1000g, Fructus Cnidii 800g, Radix Ginseng 40g, Rhizoma Curculiginis 400g, Fructus Rubi 800g, Herba Cistanches 400g, Fructus Lycii 400g, Radix Glycyrrhizae 300g, Radix Morindae Officinalis 300g.
Described technological process is: 1/3 amount of getting Radix Ginseng and Fructus Rubi is ground into fine powder; Herba Epimedii decocts with water twice, adds 10 times of amounts of water for the first time and decocts 2 hours, adds 8 times of amounts for the second time and decocts 1.5 hours, filters, and filtrate merges, and is concentrated into the clear paste (60 ℃) of relative density 1.20-1.30; Four flavors and remaining Fructus Rubi and Radix Ginseng such as all the other Fructus Cnidiis, extract three times with 75% alcohol heat reflux, for the first time add 8 times of amounts, extracted 4 hours, add 6 times of amounts for the second time, extracted 3 hours, add 4 times of amounts for the third time, extracted 3 hours, filter, filtrate merges, and reclaiming ethanol to relative density is the clear paste (60 ℃) of 1.20-1.34.With above-mentioned fine powder and clear paste mixing, dry (70 ± 5 ℃) are pulverized, and granulate, and make 1000, promptly.
Characteristics of the present invention are: " middle age is asked the multiple vigour of shaking again " is health preserving thought consistent in motherland's medical science, " old friend works as in about the middle age for the people repairs some, the foundation of then shaking again, still surplus more than half ".Illustrated and should catch not conscientious being nursed one's health of the machine of extreme deficiency syndrome as yet of middle age vigour, it is normal that vigour is able to again.Modern data shows that people's life deposit (promptly also vigor can be arranged in one's old age) is set up in middle age to just old this period just.Therefore, the sexual function of decline is gradually recovered, get final product " the old's rejuvenation, the body of middle-aged man getting stronger " in the middle age.Motherland's medical science thinks that the kidney being the origin of congenital constitution, and people's growth promoter aging course all originates from the kidney qi prosperity and decline, and proposes " kidney storing essence ", " kidney be subjected to the essence of five ZANG-organs and six FU-organs and hide it ".Modern medicine thinks that male's sexual is made up of a series of trained reflex and unconditioned reflex.And the trained reflex of property plays main effect in sexual function, but is subjected to living environment and for the influence of the various understanding of sexual life.Male sexual disorder is quite common clinically, and especially sexual impotence more more sees, this spirit sorrow, household safe and conjugal relation stability to patient often has very big influence.The Chinese medicine preparation of the treatment andropathy that the present invention relates to is the pure Chinese medicinal preparation of making according to the plus-minus side that the etiology and pathogenesis of male sexual function decline and sexual impotence selects for use Jing-Yue Complete Works " to praise and educate pellet ", does not contain any hormone.Sexual impotence one disease, " interior warp " is called " impotence ", and its origin cause of formation is belonged to " extreme exhaustion of QI and do not rise need not.All families of Tang of Sui are many from impairment caused by overstrain, the main opinion of suffering from a deficiency of the kidney "." the source of disease kidney is had one's ideas straightened out in the moon, if impairment caused by overstrain is in kidney, suffering from a deficiency of the kidney to be dissolved in cloudy gas, so a little less than withering also "; Song, bright all families have performance greatly to the principle-method-recipe-medicines of sexual impotence." Prescriptions for Succouring the Sick is deficient " said: " five kinds of strain and seven kinds of impairment, kidney-Yang is feeble and exhausted ... impotence " determines that further sexual impotence is due to the chronic consumptive disease.Jing-Yue Complete Works formally is name of disease with the sexual impotence, and doctor family of the Qing Dynasty has had suitable abundant content to the principle-method-recipe-medicines of sexual impotence.Herba Epimedii, Fructus Cnidii are monarch drug in this prescription, Herba Epimedii " so specially invigorating kidney-YANG, main impotence " " book on Chinese herbal medicine is just " wherein, and Fructus Cnidii " helps man's excessive fire " " herbal classic is met the source "; Rhizoma Curculiginis " merit is specially mended fire, supporing yang warm essence " " book on Chinese herbal medicine is looked for the truth " is a ministerial drug with the merit of principal drug assistance kidney invigorating and YANG supporting.Herba Cistanches, Fructus Lycii two flavor invigorating the liver and kidney benefiting essence-bloods, and can " prosperous and powerful vagina ", one of its purpose is the toxicity of restriction Rhizoma Curculiginis, Herba Epimedii, two be to get its " treating YANG within YIN " restriction monarch-minister drug dry mistake just, ginseng spleen strengthening nourishes heart, and is adjuvant drug with the scope of application that enlarges prescription.The Fructus Rubi supplementing the kidney to control the nocturnal makes its benefit and does not let out, and is messenger drug.The Chinese medicine preparation of this treatment andropathy that the present invention relates to is that the SHESHEN collocystis test is as follows:
Pharmacodynamics test
(1) SHESHEN collocystis has the effect of androgen sample
Excision rat bilateral testes, self-sow are divided into normal group, matched group, Fructus Aristolochiae 75,150, three dosage groups of 300mg/kg and NANBAO 500mg/kg group at random after 14 days; Every day gastric infusion once, continuous 15 days, live to kill animal after the drug withdrawal, weigh in respectively, levator ani, preputial glands, prostate and seminal fluid capsule weight, the middle and high dosage group of Fructus Aristolochiae can significantly increase important (P＜0.01) of above-mentioned accessory sex gland as a result, shows that Fructus Aristolochiae has the effect of obvious androgen sample.
(2) SHESHEN collocystis has the effect of raise immunity
After the insufficiency of kidney-YANG mouse model was duplicated in 5mg/kg/ day AIIP intramuscular injection, grouping, dosage, Therapeutic Method and time were the same.Survey mouse boosting cell T, bone-marrow-derived lymphocyte conversion value (P＜0.01) after the drug withdrawal, show that Fructus Aristolochiae has the effect of obvious enhancing body cellular immune function.
(3) radiation resistance of Fructus Aristolochiae
After kunming mice 60Co-r line shone 3Gy entirely, grouping, medication, dosage, medication and time were all the same.Look into the mouse tail blood leukocytes after the last treatment, animal extremely alive is got thymus, spleen, axillary lymph knot, testis and epididymis respectively and weighs, and its weight does not all have obvious decline (P＞0.05), shows that Fructus Aristolochiae has the Antiradiation injury effect.
(4) SHESHEN collocystis has the effect that strengthens the male rat mating ability
This result of the test shows: the big or middle dosage of SHESHEN collocystis all can shorten male rat and pounce on and catch and ejaculation latency, increase to pounce on and catch and ejaculation frequency, can improve to pounce on and catch and the percentage rate of ejaculating (P＜0.01, or P＜0.05), illustrate that this product has the effect that strengthens the male rat mating ability.
Toxicological test
1, Fructus Aristolochiae chmice acute toxicity test shows, 16g/kg Fructus Aristolochiae aqueous suspension once irritates stomach for mice, observes seven days no animal deads, and through acute toxicity dose grading standard, this reagent belongs to nontoxic level by " medicine toxicity ".Since mouse stomach administration capacity reached limiting quantity (＜1.0ml=), so this medicine can not be measured LD
50Value.
2, long term toxicity test shows, Fructus Aristolochiae is given rat continuous irrigation stomach 90 days, and each dosage treated animal body weight, leukocyte, hemoglobin, hepatic and renal function and organ weights and histological examination there is no unusually, point out this medicine not have the intoxicating effect.
The specific embodiment
1/3 amount of getting was ground into fine powder after embodiment 1 got Radix Ginseng 40g and Fructus Rubi 800g mixing; Herba Epimedii 1000g decocts with water twice, adds 10 times of amounts of water for the first time and decocts 2 hours, adds 8 times of amounts for the second time and decocts 1.5 hours, filters, and filtrate merges, and is concentrated into the clear paste (60 ℃) of relative density 1.20-1.30; All the other Fructus Cnidii 800g, Rhizoma Curculiginis 400g, Herba Cistanches 400g, Fructus Lycii 400g and remaining Fructus Rubi and Radix Ginseng, extract three times with 75% alcohol heat reflux, for the first time add 8 times of amounts, extracted 4 hours, add 6 times of amounts for the second time, extracted 3 hours, add 4 times of amounts for the third time, extracted 3 hours, filter, filtrate merges, and reclaiming ethanol to relative density is the clear paste (60 ℃) of 1.20-1.34.With above-mentioned fine powder and clear paste mixing, dry (70 ± 5 ℃) are pulverized, and granulate, and make 1000, promptly.
It is that composition increases to some extent that embodiment 2 compares with embodiment 1, and its prescription is: Herba Epimedii 1000g, Fructus Cnidii 800g, Radix Ginseng 40g, Rhizoma Curculiginis 400g, Fructus Rubi 800g, Herba Cistanches 400g, Fructus Lycii 400g, Radix Glycyrrhizae 300g, Radix Morindae Officinalis 300g, all the other production technologies are identical with embodiment 1.
Model case
1, contain * *, man, 27 years old, first marriage.Before two weeks and in wife's sexual intercourse climax, frightened suddenly, cause the penis anorthosis.Though twice diagnosis and treatment, it is invalid to take multi-agent Chinese medicine.See that now patient's complexion is black yellow.And the cloudy woeful expression of little band, dimly red tongue, thin white fur of tongue, stringy pulse.Examine and be fear impairing kidney.4 of SHESHEN collocystis are taken in treatment, every day 2 times, and spirit is pacified.In two weeks of medication, patient and wife state symptom and take a turn for the better with coming further consultation, and sleep is normal, and in waking up night, external genitals also gradually has the sense of erection, and look into: dimly red tongue disappears, stringy and thready pulse.Advise continuous clothes 4 weeks of SHESHEN collocystis, follow up a case by regular visits to disease and cure.
2, Zhao *, the man, 50 years old, married.Easily have a dizzy spell usually, fatigue in both spirit and physical strength, soreness of the spinal column, sexual life is out of fashion, and penis is lifted and not hard, and nearly two all subjective symptomss increase the weight of, impotence and going to a doctor.Look into and see patient's pale complexion, lethargy, lumbago is aching and limp, tinnitus, pale tongue with white fur, deep-thready pulse.Examine and be the insufficiency of kidney-YANG sexual impotence.Medicinal SHESHEN collocystis, each 4, every day 2 times.Take two week back symptoms and take a turn for the better, have a dizzy spell, soreness of the waist and knees obviously alleviates, complexion has China.Advise continuous 4 weeks of clothes, check erection, sexual life is normal, clinical symptom disappearance.
Claims (6)
1, a kind of Chinese medicine preparation for the treatment of andropathy, it is characterized in that: its main component comprises Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Herba Cistanches 1%-75%.
2, a kind of Chinese medicine preparation for the treatment of andropathy according to claim 1, it is characterized in that: described composition comprises Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Fructus Rubi 1.5%-80%, Herba Cistanches 1%-75%, Fructus Lycii 1%-75%.
3, a kind of Chinese medicine preparation for the treatment of andropathy according to claim 1, it is characterized in that: described composition includes: Herba Epimedii 2%-85%, Fructus Cnidii 1.5%-80%, Radix Ginseng 0.5%-70%, Rhizoma Curculiginis 1%-75%, Fructus Rubi 1.5%-80%, Herba Cistanches 1%-75%, Fructus Lycii 1%-75%, Radix Glycyrrhizae 0.1-50%, Radix Morindae Officinalis 0.1%-50%.
4, a kind of Chinese medicine preparation for the treatment of andropathy according to claim 1, it is characterized in that: described composition has: Herba Epimedii 1000g, Fructus Cnidii 800g, Radix Ginseng 40g, Rhizoma Curculiginis 400g, Fructus Rubi 800g, Herba Cistanches 400g, Fructus Lycii 400g.
5, a kind of Chinese medicine preparation for the treatment of andropathy according to claim 1, it is characterized in that: described composition has: Herba Epimedii 1000g, Fructus Cnidii 800g, Radix Ginseng 40g, Rhizoma Curculiginis 400g, Fructus Rubi 800g, Herba Cistanches 400g, Fructus Lycii 400g, Radix Glycyrrhizae 300g, Radix Morindae Officinalis 300g.
6, a kind of Chinese medicine preparation for the treatment of andropathy according to claim 1 is characterized in that: described technological process is that 1/3 amount of getting Radix Ginseng and Fructus Rubi is ground into fine powder; Herba Epimedii decocts with water twice, adds 10 times of amounts of water for the first time and decocts 2 hours, adds 8 times of amounts for the second time and decocts 1.5 hours, filters, and filtrate merges, and is concentrated into the clear paste (60 ℃) of relative density 1.20-1.30; Four flavors and remaining Fructus Rubi and Radix Ginseng such as all the other Fructus Cnidiis, extract three times with 75% alcohol heat reflux, for the first time add 8 times of amounts, extracted 4 hours, add 6 times of amounts for the second time, extracted 3 hours, add 4 times of amounts for the third time, extracted 3 hours, filter, filtrate merges, and reclaiming ethanol to relative density is the clear paste (60 ℃) of 1.20-1.34.With above-mentioned fine powder and clear paste mixing, dry (70 ± 5 ℃) are pulverized, and granulate, and make 1000, promptly.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638270A (en) * | 2013-11-26 | 2014-03-19 | 青岛安信医疗器械有限公司 | Traditional Chinese medicine liquid for treating male infertility and preparation method thereof |
| CN104524130A (en) * | 2015-01-08 | 2015-04-22 | 张其慧 | Chinese herb preparation treating planned parenthood ligation sequela |
| CN105878662A (en) * | 2015-01-18 | 2016-08-24 | 颜学 | Traditional Chinese medicinal composition of yin-nourishing and yang-tonifying wine capable of preventing and treating impotence, premature ejaculation as well as sexual apathy |
| CN106237064A (en) * | 2016-08-24 | 2016-12-21 | 刘亚林 | A kind of traditional Chinese medicine for invigorating kidney and strengthening yang preparation |
| CN106236963A (en) * | 2016-08-26 | 2016-12-21 | 温红卫 | A kind of Traditional Chinese medicine tincture preparation treating impotence and premature ejaculation and preparation method thereof |
| CN106309730A (en) * | 2016-09-26 | 2017-01-11 | 周晓浩 | Yang invigorating and qi tonifying wine |
| CN110859918A (en) * | 2019-12-09 | 2020-03-06 | 华中科技大学同济医学院附属协和医院 | Medicine and food homologous prescription for treating kidney-yang deficiency and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1215598A (en) * | 1997-10-08 | 1999-05-05 | 西安恒生堂制药有限公司 | Capsule for nourishing kidney and strengthening Yang |
| CN1197609C (en) * | 2003-03-27 | 2005-04-20 | 华东中药工程集团有限公司 | Chinese medicine for treating impotence and its preparation method |
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2004
- 2004-12-13 CN CNB2004100733973A patent/CN1325085C/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103638270A (en) * | 2013-11-26 | 2014-03-19 | 青岛安信医疗器械有限公司 | Traditional Chinese medicine liquid for treating male infertility and preparation method thereof |
| CN104524130A (en) * | 2015-01-08 | 2015-04-22 | 张其慧 | Chinese herb preparation treating planned parenthood ligation sequela |
| CN105878662A (en) * | 2015-01-18 | 2016-08-24 | 颜学 | Traditional Chinese medicinal composition of yin-nourishing and yang-tonifying wine capable of preventing and treating impotence, premature ejaculation as well as sexual apathy |
| CN106237064A (en) * | 2016-08-24 | 2016-12-21 | 刘亚林 | A kind of traditional Chinese medicine for invigorating kidney and strengthening yang preparation |
| CN106236963A (en) * | 2016-08-26 | 2016-12-21 | 温红卫 | A kind of Traditional Chinese medicine tincture preparation treating impotence and premature ejaculation and preparation method thereof |
| CN106309730A (en) * | 2016-09-26 | 2017-01-11 | 周晓浩 | Yang invigorating and qi tonifying wine |
| CN110859918A (en) * | 2019-12-09 | 2020-03-06 | 华中科技大学同济医学院附属协和医院 | Medicine and food homologous prescription for treating kidney-yang deficiency and preparation method thereof |
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| CN1325085C (en) | 2007-07-11 |
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Assignee: Hengshengtang Pharmaceutical Co., Ltd., Xi'an City Assignor: Xi'an Hasana Investment Co. Ltd. Contract fulfillment period: 2009.11.25 to 2010.11.25 contract change Contract record no.: 2009610000064 Denomination of invention: Chinese materia medica preparation for treating andropathy Granted publication date: 20070711 License type: General permission Record date: 20091125 Assignee: Hengshengtang Pharmaceutical Co., Ltd., Xi'an City Assignor: Xi'an Hasana Investment Co. Ltd. Contract fulfillment period: 2008.11.5 to 2018.11.4 contract change Contract record no.: 2009610000098 Denomination of invention: Chinese materia medica preparation for treating andropathy Granted publication date: 20070711 License type: Exclusive license Record date: 2009.12.1 |
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