CN100366272C - Medicine for treating diabetic nephropathy - Google Patents
Medicine for treating diabetic nephropathy Download PDFInfo
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- CN100366272C CN100366272C CNB2005100174485A CN200510017448A CN100366272C CN 100366272 C CN100366272 C CN 100366272C CN B2005100174485 A CNB2005100174485 A CN B2005100174485A CN 200510017448 A CN200510017448 A CN 200510017448A CN 100366272 C CN100366272 C CN 100366272C
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Abstract
The present invention relates to a medicine for treating diabetic nephropathy, more specifically to a Chinese patent medicine prepared from Chinese herbal medicines as raw materials. The Chinese patent medicine is prepared from components in the following part by weight: 10 to 15 of milkvetch root, 15 to 20 of prepared rehmannia root, 15 to 20 of kudzuvine root, 7.5 to 10 of Chinese angelica, 7.5 to 10 of areca peel, 23 to 30 of Polyporus Umbellatus, 23 to 30 of motherwort herb, 7.5 to 10 of fried Semen Cassiae, 7.5 to 10 of periostracum cicadae, 7.5 to 10 of Dendranthema Morifolium, 7.5 to 10 of common scouring rush herb and 10 to 12 of white mulberry root-bark. The present invention has the effects of lowering blood sugar and blood lipid, eliminating the hypercoagulabale state of blood, improving microcirculation, promoting the secretion of endogenous insulin, expelling insulin resistance in the blood, enhancing organism immunity and preventing and treating complications.
Description
Technical field
The present invention relates to a kind of treatment diabetic nephropathy drugs, is the Chinese patent medicine of feedstock production specifically with the Chinese herbal medicine, the promptly flat KidneyHarmonizing Pill that disappears.
Background technology
Diabetes are a kind of general, metabolic disease, and along with human living standard's the raising and the prolongation of life insurance, its sickness rate rises rapidly in countries in the world, and the sickness rate of China's diabetes reaches about 5%.The metabolism disorder that diabetes are serious causes a series of acute complicationses such as infection, ketoacidosis, hyperosmolar coma.And long-term hyperglycemia is to the sugared toxicity of body tissue and organ generation, cause a series of chronic complicating diseases such as diabetes nephropathy, neuropathy, retinopathy and diabetic gangrene, diabetes still are the factor that diseases such as atherosclerosis and hypertension are brought out and increased the weight of simultaneously, so diabetes become the three big pertinacious diseases that threaten human health and life with the heart, cerebrovascular and cancer.
At present, treatment of diabetes is run into the following problem that is difficult to resolve both at home and abroad:
1, the biguanide drug curative effect is low, side effect is big, for a long time with producing hyperlactacidemia.
2, the sulfonylurea medicine with infringement liver, kidney and hemocyte, produces cross allergy with sulphonamides for a long time, and the later stage produces secondary and lost efficacy.
3, with producing antibody, biological activity reduces insulin for a long time, and dosage increases, and produces hyperinsulinemia, increases the weight of insulin resistant, impels microangiopathic generation and development.
Though 4 also have the Chinese patent medicine of some treatment diabetes, effect is very not obvious, and the patient has to depend on some Western medicine.
5, the complication of diabetes there is not effective medicine.
From above-mentioned analysis as can be known, though present various kinds of drug has the effect of blood sugar lowering, helpless to the prevention and the treatment of complication.
Summary of the invention
The object of the present invention is to provide a kind of have blood sugar lowering, blood fat reducing, improve high blood coagulation state, microcirculation improvement, promote endogenous secretion of insulin, eliminate the insulin resistant in the blood, enhancing human body immunity, the Remedies for diabetes of prevention and the effect of treatment complication.
The present invention program's generation is based on the understanding of motherland's medical science to the occurrence cause and the pathomechanism of diabetes and complication thereof, the utilization Basic Theories of Chinese Medicine, and from macroscopic view, dialectical opinion is controlled, and achieves with reference to modern pharmacological research; The clinical research of collection more than ten years; from motherland's medical treasure-house; filter out nourishing kidney-yin, QI invigorating void, change congestion, pure and impurely let out, the natural medicinal plant of the body resistance strengthening and constitution consolidating; by the theory of Chinese medical science prescription; skim the cream off milk; make its performance promote endogenous insulin secretion; protection insulin cell function; eliminate insulin resistant in the blood, increase its biological activity, promote the metabolism of sugar; reduce fat, proteinic decomposition; blood glucose, blood fat, blood viscosity are reduced, microcirculation improvement, the effect of prevention and treatment diabetes and complication thereof.
The present invention is to be that the component of weight portion is made by following weight:
The Radix Astragali 10～15 Radix Rehmanniaes Preparata 15～20 Radix Puerariaes 15～20 Radix Angelicae Sinensis 7.5～10
Pericarpium Arecae 7.5～10 Polyporus 23～30 Herba Leonuris 23～30 Semen Cassiae (parched) 7.5～10
Periostracum Cicadae 7.5～10 Flos Chrysanthemi 7.5～10 Herba Equiseties Hiemalis 7.5～10 Cortex Mori 10～12
Formula optimization weight (part) ratio range of preparation medicine of the present invention is:
The Radix Astragali 12～14 Radix Rehmanniaes Preparata 17～18 Radix Puerariaes 17～18 Radix Angelicae Sinensis 8～9
Pericarpium Arecae 8～9 Polyporus 25～28 Herba Leonuris 25～28 Semen Cassiae (parched) 8～9
Periostracum Cicadae 8～9 Flos Chrysanthemi 8～9 Herba Equiseties Hiemalis 8～9 Cortex Mori 10.5～11
The optimum weight of medicine of the present invention (part) proportioning is:
The Radix Astragali 12 Radix Rehmanniaes Preparata 18 Radix Puerariaes 18 Radix Angelicae Sinensis 8.5
Pericarpium Arecae 8 Polyporus 26 Herba Leonuris 27 Semen Cassiae (parched) 8
Periostracum Cicadae 8.5 Flos Chrysanthemi 9 Herba Equiseties Hiemalis 8 Cortex Mori 11
The method of above-mentioned each component being made medicine of the present invention is:
(1) Radix Angelicae Sinensis, Semen Cassiae (parched), Periostracum Cicadae, Flos Chrysanthemi, Polyporus, Radix Puerariae are cleaned, dry, pulverized, cross 100 mesh sieves, fine powder is standby.
(2) all the other 6 kinds of medicine water boiling concentration are extracted, extractum oven dry, levigation.
(3) be mixed the medical material fine powder even.
(4) controlling the water circulation ball, Φ 1.5mm, per 30 are equivalent to crude drug in whole 3g.
Drug agents of the present invention is a pill.
Drug weight proportioning of the present invention, method for making meet the standard of the Pharmacopoeia of the People's Republic of China.
An important feature of the present invention is to contain abundant choline material and flavone compound; albumen nonenzymatic glycosylation and aldose reductase there is inhibitory action; can blood fat reducing, blood viscosity lowering, blood vessel dilating; improve blood flow state; promote microcirculation, increase the islets of langerhans hemoperfusion, protect the function of remaining islet cells; peripheral organizations such as promotion muscle prevent diabetes complicated microangiopathies effectively to the picked-up utilization of glucose.
Another important feature of the present invention is: selecting natural Chinese medicine for use is raw material, according to the meridian distribution of property and flavor and the modern pharmacology research of medicine, and scientific combination, thus reach optimum therapeuticing effect.In the side with the yin nourishing of nourishing blood of Radix Rehmanniae Preparata, Radix Puerariae, promoting the production of body fluid to quench thirst; The Radix Angelicae Sinensis hemopoietic of invigorating blood circulation, Herba Leonuri eliminating phlegm to promote tissue regeneration, spasmolytic blood pressure lowering, Semen Cassiae (parched) is grown liver and kidney tonifying, and the diuretic that makes eye bright is aided with Pericarpium Arecae, Polyporus promoting diuresis with drugs of tasteless flavour again, and with Radix Astragali tonification healthy energy.All medicines share, supplementing QI and nourishing YIN, and the astringency inducing the kidney invigorating, the treating blood disorders collateral dredging, block removing makes eye bright.Clinical trial shows, this agent can change hemorheological hypercoagulability, resists platelet aggregation and thrombosis, removes small blood vessel spasm, blood vessel dilating, increase the hemoperfusion of tissue, microcirculation improvement, blood fat reducing and cholesterol, eliminate albuminuria, blood sugar lowering, blood pressure, and can increase body immunity, effective treatment and diabetes complicated blood capillary medical histories such as prevent diabetes, nephropathy and diabetes, oculopathy.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select natural drug for use be raw material in the present invention, and each component meets the Medicine Act regulation, utilizes the comprehensive function treatment diabetic nephropathy of the Chinese medicine of respectively distinguishing the flavor of, nontoxic.
2, steady blood sugar lowering, glucose in urine, blood fat and blood viscosity, and should not rebound after the drug withdrawal, clinical symptoms such as polydipsia, polyphagia, polyuria, fatigue and weakness, sensation of oppression over the chest with shortness of breath eliminated.
3, significantly reduce the extent of damage of islet cells, the protection islet function is eliminated insulin resistant.
4, effectively eliminate diabetic complication, improve vascular function, function of nervous system, function, be applicable to diabetes cardiovascular and cerebrovascular disease, diabetic nephropathy, diabetic ophthalmopathy, diabetic peripheral neuropathy etc.
5, balance internal organs negative and positive, the human body immunity improving ability.
6, taking convenience, safe and reliable.
For showing medicine of the present invention to the treatment of diabetes effect, the present invention is through the clinical observation of 450 routine systems, and selection medical history, the state of an illness, age, sex and suitable diabetics 103 examples of former Therapeutic Method are matched group.From being in hospital and case history is selected in the department of endocrinology outpatient service, meet the standard by stages of the diabetic nephropathy that relevant diabetes diagnosis standard of american diabetes association in 1997 and Mogensen1989 propose, belong to the patient of three phase diabetic nephropathyes.On the basis of dietetic therapy and pharmacotherapy, the control fasting glucose is the object of observation 6.0～6.8mmol/L person, wherein male 215 examples, women 225 examples, 37～68 years old age, the course of disease 8～15 years.Experimental group is withdrawn lipid lowerers on former treatment basis, obey medicine of the present invention; Matched group is blood sugar lowering, the treatment of blood fat reducing blood vessel dilating routinely.Adopt same procedure to make regular check on blood glucose, blood fat and microdose urine protein, three months observation periods, one month is a course of treatment, totally three courses of treatment.
1, to the influence of microdose urine protein discharge rate
| n | Before the treatment (ug/min) | Treatment back (ug/min) | Difference (ug/min) | |
| The treatment group | 450 | 138±56 | 7.8±6.5 | 130.2±49.5 |
| Matched group | 103 | 129±54 | 118±46 | 11±8 |
The comparison of two groups of treatment front and back microdose urine protein discharge rates: P＜0.01, compare between group: P＜0.01.
Seen that by last table the treatment group has the albuminuretic effect of good elimination, relatively, the treatment group obviously is better than matched group, has utmost point significant difference between two groups, illustrates that the flat KidneyHarmonizing Pill that disappears has the effect for the treatment of diabetic nephropathy preferably.
2, to the influence of blood fat
| n | Before the treatment (mmol/L) | Treatment back (mmol/L) | Difference (mmol/L) | ||||
| TC | TG | TC | TG | TC | TG | ||
| The treatment group | 450 | 5.80±0.89 | 1.96+037 | 4.73+0.77 | 1.36±0.41 | 0.57±023 | 0.36±0.15 |
| Matched group | 103 | 5.76±0.69 | 1.96±0.41 | 5.33±0.85 | 1.74±0.52 | 0.21±0.10 | 0.13±0.10 |
Blood Lipid is relatively before and after the treatment: P＜0.05, compare between group: P＜0.01.
As seen from the above table, the treatment group has tangible reduction effect to T-CHOL, triglyceride, and matched group does not then have significant change.
3, clinical observation on the therapeutic effect
| Grouping | Case load | The produce effects example | Effectively routine | Invalid example | Effective percentage % |
| The treatment group | 450 | 318 | 107 | 16 | 96.45 |
| Matched group | 103 | 36 | 41 | 26 | 75.12 |
There were significant differences for two groups of total effective rates: P＜0.01.
Model case:
Case one
Patient: woman, 52 years old
First visit, diabetes 7 years were once taken glyburide, insoral, diabetes pill etc., look into fasting glucose 6.8mmol/L, GHb8.0%, glucose in urine ++, urine protein ++, 24h urine protein quantitation 240mg, triglyceride 2.2mmol/L, BP160/100mmHg, thirsty polydipsia, the lower limb pitting edema, spirit is tired, the soreness of waist, dizzy insomnia.
Diagnosis: diabetes (kidney-yin deficiency type)
Diabetic nephropathy
Treatment: QI invigorating, nourishing kidney, yin nourishing
Blood sugar lowering, blood pressure lowering, blood fat reducing, correction albuminuria
Prescription: flat 30 day of KidneyHarmonizing Pill 3 times of disappearing, oral
Two examine, and the back of taking medicine is thirsty ends, and dizzy insomnia has improvement, surveys fasting glucose 6.0mmol/L, urine protein+.
Continue to take medicine flat 30 day of KidneyHarmonizing Pill 3 times of disappearing, oral
Three examine, and patient spirit is good, thirstyly end, relax diet, and edema disappears entirely, and sleep is normal, surveys fasting glucose 5.7mmol/L, urine protein-, glucose in urine-, BP130/80mmHg.Continuing former side takes medicine.
Follow-up investigations, patient's spirit is good, and diet is normal, blood glucose 5.3-5.7mmol/L, GHb5.5%, TG0.8mmol/L, routine urinalysis is normal, urinary protein excretion 24mg/24h, BP130/80mmHg.
Case two
Patient: man, 67 years old
First visit, diabetes 15 years were once taken tolbutamide, glyburide, metformin, diabetes pill etc., thirsty polydipsia, the tired power of body, puffiness of the face and limbs, poor appetite abdominal distention, look into FBG12mmol/L, 2 hours after the meal blood glucose 16mmol/L, GHB9.8%, glucose in urine +++, urine protein ++, urinary protein excretion 600mg/24h, BP160/100mmHg.
Diagnosis: diabetes (deficiency of both QI and YIN becomes silted up and hinders the venation type)
The diabetic nephropathy fourth phase
Treatment: supplementing QI and nourishing YIN, nourishing kidney
Blood sugar lowering, albuminuria is corrected in blood pressure lowering
Prescription: injection of insulin
Flat 30 day of KidneyHarmonizing Pill 3 times of disappearing, oral
Two examine, and thirstyly end the back of taking medicine, and spirit takes a turn for the better, and edeam of legs disappears, and play face and still have edema morning, and the insulin blood sugar control is at 6.0～6.8mmol/L.
Take medicine according to commercial weight: flat 30 day of KidneyHarmonizing Pill 3 times of disappearing, oral.
Days three examine, and thirstyly end, and puffiness of the face and limbs disappears, and nocturia is many slightly, and abdominal distention disappears, and diet relaxes, the sugared 6.2mmol/L that has a blood test, and glucose in urine-, urine protein-.
Still with the insulin blood sugar control, flat 30 of the KidneyHarmonizing Pills of disappearing, days 3 times, oral.
Tracing observation, the sugared 6.0mmol/L that has a blood test after March, GHb6%, glucose in urine-, urine protein-, urinary albumin excretion 28mg/24h, BP130/84mmHg; Patient's spirit is good, thirsty ending, and diet is normal, and no abdominal distention is large and small just normal, continues to take the flat KidneyHarmonizing Pill that disappears, and strengthens the effect of supplementing QI and nourishing YIN.
The specific embodiment
Embodiment 1
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 10 Radix Rehmanniaes Preparata 15 Radix Puerariaes 15 Radix Angelicae Sinensis 7.5 Pericarpium Arecae 7.5
Polyporus 23 Herba Leonuris 23 Semen Cassiae (parched) 7.5 Periostracum Cicadaes 7.5 Flos Chrysanthemi 7.5
Herba Equiseti Hiemalis's 7.5 Cortex Mori 10
Production method is as follows:
(1) Radix Angelicae Sinensis, Semen Cassiae (parched), Periostracum Cicadae, Flos Chrysanthemi, Polyporus, Radix Puerariae are cleaned, dry, pulverized, cross 100 mesh sieves, fine powder is standby.
(2) all the other 6 kinds of medicine water boiling concentration are extracted, extractum oven dry, levigation.
(3) be mixed the medical material fine powder even.
(4) controlling the water circulation ball, 1.5mm, per 30 are equivalent to crude drug in whole 3g.
Embodiment 2
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 12 Radix Rehmanniaes Preparata 18 Radix Puerariaes 18 Radix Angelicae Sinensis 8.5
Pericarpium Arecae 8 Polyporus 26 Herba Leonuris 27 Semen Cassiae (parched) 8
Periostracum Cicadae 8.5 Flos Chrysanthemi 9 Herba Equiseties Hiemalis 8 Cortex Mori 11
Production method is with embodiment 1.
Embodiment 3
Take by weighing raw material (gram) by following proportioning:
The Radix Astragali 15 Radix Rehmanniaes Preparata 20 Radix Puerariaes 20 Radix Angelicae Sinensis 10 Pericarpium Arecae 10
Polyporus 30 Herba Leonuris 30 Semen Cassiae (parched) 10 Periostracum Cicadaes 10 Flos Chrysanthemi 10
Herba Equiseti Hiemalis's 10 Cortex Mori 12
Production method is with embodiment 1.
Claims (4)
1. treat diabetic nephropathy drugs for one kind, it is characterized in that making by following weight parts proportion raw material medicine:
The Radix Astragali 10～15 Radix Rehmanniaes Preparata 15～20 Radix Puerariaes 15～20 Radix Angelicae Sinensis 7.5～10
Pericarpium Arecae 7.5～10 Polyporus 23～30 Herba Leonuris 23～30 Semen Cassiae (parched) 7.5～10
Periostracum Cicadae 7.5～10 Flos Chrysanthemi 7.5～10 Herba Equiseties Hiemalis 7.5～10 Cortex Mori 10～12.
2. treatment diabetic nephropathy drugs according to claim 1 is characterized in that being made by following weight parts proportion raw material medicine:
The Radix Astragali 12～14 Radix Rehmanniaes Preparata 17～18 Radix Puerariaes 17～18 Radix Angelicae Sinensis 8～9
Pericarpium Arecae 8～9 Polyporus 25～28 Herba Leonuris 25～28 Semen Cassiae (parched) 8～9
Periostracum Cicadae 8～9 Flos Chrysanthemi 8～9 Herba Equiseties Hiemalis 8～9 Cortex Mori 10.5～11.
3. treatment diabetic nephropathy drugs according to claim 1 is characterized in that being made by following weight parts proportion raw material medicine:
The Radix Astragali 12 Radix Rehmanniaes Preparata 18 Radix Puerariaes 18 Radix Angelicae Sinensis 8.5
Pericarpium Arecae 8 Polyporus 26 Herba Leonuris 27 Semen Cassiae (parched) 8
Periostracum Cicadae 8.5 Flos Chrysanthemi 9 Herba Equiseties Hiemalis 8 Cortex Mori 11.
4. according to claim 1,2 or 3 described treatment diabetic nephropathy drugs, it is characterized in that: said medicine is a pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174485A CN100366272C (en) | 2005-03-28 | 2005-03-28 | Medicine for treating diabetic nephropathy |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100174485A CN100366272C (en) | 2005-03-28 | 2005-03-28 | Medicine for treating diabetic nephropathy |
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| CN1840049A CN1840049A (en) | 2006-10-04 |
| CN100366272C true CN100366272C (en) | 2008-02-06 |
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| CNB2005100174485A Expired - Fee Related CN100366272C (en) | 2005-03-28 | 2005-03-28 | Medicine for treating diabetic nephropathy |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101780067B (en) * | 2009-01-16 | 2012-05-30 | 康臣药业(内蒙古)有限责任公司 | Pharmaceutical composition for treating diabetic nephropathy and preparation method and application |
| CN103392874A (en) * | 2013-08-03 | 2013-11-20 | 北京绿源求证科技发展有限责任公司 | Food-grade health tea soluble granules capable of nourishing kidney |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
| CN1413629A (en) * | 2002-06-06 | 2003-04-30 | 孙克刚 | Oral liquid for nourishing yin and warming yang |
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2005
- 2005-03-28 CN CNB2005100174485A patent/CN100366272C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131020A (en) * | 1995-03-11 | 1996-09-18 | 朱立群 | Medicine for reducing blood sugar and its preparation method and use |
| CN1413629A (en) * | 2002-06-06 | 2003-04-30 | 孙克刚 | Oral liquid for nourishing yin and warming yang |
Non-Patent Citations (1)
| Title |
|---|
| 糖尿病肾病中医药研究进展近况. 舒占均.新疆中医药，第22卷第2期. 2004 * |
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