CN1231196A - Capsule for promoting male sexual function and preparation process - Google Patents
Capsule for promoting male sexual function and preparation process Download PDFInfo
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- CN1231196A CN1231196A CN98113890A CN98113890A CN1231196A CN 1231196 A CN1231196 A CN 1231196A CN 98113890 A CN98113890 A CN 98113890A CN 98113890 A CN98113890 A CN 98113890A CN 1231196 A CN1231196 A CN 1231196A
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- capsule
- male sexual
- treatment
- decocting
- sexual hypofunction
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Abstract
The capsule for curing male sexual hypofunction is prepared from the Chinese medicinal materials of cistanche stem, lycium berry, cornus fruit, morinda root, deerhorn glue, prepared rehmannia root and cuscuta seed through, decocting them in water three times respectively for 2 hr and 1 hr, filtering, combining the above-mentioned three decoctions, depressurized concentration to obtaine paste, drying, pulverizing to obtain medicinal powder, and capsulizing to obtain the invented finished product with the functions of enriching Yin, nourishing kidney, warming kidney, invigorating Yang, tonifying marrow and replenishing essence, etc..
Description
The present invention relates to a kind of capsule and manufacture method for the treatment of male sexual hypofunction.
Clinical proof, sexual hypofunction substantially can be divided into spirituality and organ two classes, and spirituality sees psychic traumas such as scaring was arranged in the sexual life process, spiritual overtired, nervous, anxiety, depression.Conjugal relation is inharmonious or suspect mutually, sexual life overfrequency or long-term masturbation, excessive drinking, smoking, bad habit such as take medicine.Still Chinese Traditional Medicines at present preferably are of no curative effect.
The purpose of this invention is to provide a kind of capsule and manufacture method that adopts the traditional Chinese medical herbal treatment male sexual hypofunction, it has the effect of enriching yin and nourishing kidney, warming the kidney to invigorate YANG, beneficial marrow and benefitting semen.
For achieving the above object, technical solution of the present invention is: a kind of capsule for the treatment of male sexual hypofunction, and the various compositions of its making prescription are by weight: Herba Cistanches: FRUCTUS LYCII: Fructus Corni: crust halberd: Colla cornus cervi: Radix Rehmanniae Preparata: field dobber=(1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.5-2.0): (0.8-1.0);
Can assist in addition and add following composition, be by weight: Radix Angelicae Sinensis: the Cortex Eucommiae: fry Leek: Rhizoma Curculiginis: Herba Epimedii: Fructus Cnidii: interior osmanthus: Radix Rehmanniae: Radix Achyranthis Bidentatae: Poria=(1.0-1.2): (1.0-1.2): (1.0-1.2): (2.5-3.0): (2.5-3.0): (1.0-1.5): (0.8-1.0): (0.8-1.0): (0.8-1.0): (0.8-1.0);
Manufacture method: above-mentioned raw materials is added the octuple decocting for the first time boiled 2 hours, leach decocting liquid, add five times of water for the second time, decoct and leached decocting liquid in 1 hour, add water for the 3rd time and decoct for three times and leached decocting liquid in 1 hour, merges three decocting liquids and concentrating under reduced pressure receipts cream, drying and crushing gets powder, incapsulates.
Hypofunction has accumulated abundant treatment experience to motherland's medical science to therapeutic, with Herba Cistanches, Radix Morindae Officinalis, Fructus Cnidii, field dobber kidney-replenishing, Radix Rehmanniae Preparata, Fructus Lycii nourishing kidney yin, make the unlikely rising of kidney yang, the Cortex Eucommiae, Radix Achyranthis Bidentatae the kidney invigorating are with strong waist knee joint, Poria reinforcing the heart gas, Radix Angelicae Sinensis reinforcing the heart blood, Herba Epimedii invigorating the liver and kidney and strengthening bone and muscle is high under the Colla cornus cervi temperature compensation, the nourishing YIN the yang aspect of yang, dredging DU Meridian feeling pulse blood, thereby obey this prescription can As the medicine took effect, the symptoms lessened.It has the effect of enriching yin and nourishing kidney, warming the kidney to invigorate YANG, beneficial marrow and benefitting semen, use a course of treatment by clinical hundreds of routine patients after, patient's subjective symptoms is clearly better, and is energetic, libido obviously improves, and uses two courses of treatment and cures substantially.
This medicine shows that through the acute and sub-acute toxicity test of Jilin Province's Siping City medicine inspecting institute this product toxicity is lower, for clinical drug safety provides reliable basis.
Zoopery is as follows: Kunming kind white mice, body weight 18-22 gram, male and female half and half, rat body weight 80-100 gram, male and female half and half, animal feeding room and observation ward, sunny, temperature, suitable, the well-ventilated of humidity, feedstuff and water all satisfy supply, and feedstuff is provided by animal housing of Bethune medical university.
1, acute toxicity testing
Method: get 20 of white mice, fasting (can't help water) was pressed maximal dose 0.5ml/10g after 17 hours, and gastric infusion is 2 times in one day, observed continuously seven days, and poisoning symptom and death toll appear in the record animal.
The result: the poisoning symptom and the phenomena of mortality all do not appear in animal, after all animal vias become celestial, and each main organs no abnormality seen.This dosage is equivalent to 70 kilograms of body weight or people's consumption 700 times, LD
50Greater than 20g/kg.
2, sub-acute toxicity test
Method: get 30 of rat and be divided into 3 groups at random, every group 10, matched group (with the volume normal saline), high dose (14g/kg), low dose group (10g/kg) gastric infusion every day once, successive administration 30 days was weighed once in per three days, and the last administration is after 24 hours, each organizes equal sacrificed by decapitation, check routine blood test, glutamate pyruvate transaminase and non-protein nitrogen, and core, important organs such as liver, lung, spleen, kidney, testis, ovary claim weight in wet base, carry out check pathological section.
The result: administration group high dose (350 times of people's consumptions), low dosage (250 times of people's consumptions) compare with matched group, the content of the red white corpuscle number in the blood, hemoglobin, platelet value, glutamate pyruvate transaminase and non-protein nitrogen, with the relatively more equal no significant difference of matched group, mathematical statistics P value is greater than 0.1.Illustrate that this product do not have obvious influence to its routine blood test, lung, renal function, pathological section does not see that important organs such as the heart, liver, lung, spleen, kidney have the pathological change of drug-induced.
Successively use this product and treat 30 examples, obtain curative effect preferably, now be summarized as follows:
One, a year order distributes: table 1
Sum (example) | 25-35 year | 36-46 year | 47-60 is more than year |
50 | ????8 | ????12 | ????30 |
Two, course of disease information slip 2
Sum (example) | More than half a year | More than 1 year | More than 1 year |
50 | ????8 | ????16 | ????26 |
Three, symptom and sign table 3
Symptom | Primary symptom | Inferior disease | Tongue fur | The arteries and veins picture | ||||||||
Impotence | Soreness of waist foot is soft | Dampness of scrotum | Dysuria | Palpitation with a distress feeling is forgetful | Dysphoria and insomnia | Not anti-stride | Matter is red | Yellow fur is thick | Tongue is brown secretly thick | Stringy and thready pulse | Rolling pulse is floating | |
The example number | ????50 | ????50 | ????36 | ????32 | ????28 | ????21 | ????13 | ????16 | 12 | ?22 | ???12 | ?38 |
According to above-mentioned symptom, tongue, arteries and veins picture are analyzed, and meet spleen-kidney vacuity cold, syndrome that damage of essence gas is few.
Four, test method:
This disease patient 50 examples are selected in outpatient service, take this product, obey every day three times (daytime secondary, be taken at bed time with once), and each 2 grams, 15 days be a treatment journey, generally take three courses of treatment.
Five, result of the test:
(1) curative effect: table 4
Sum (example) | Clinical cure (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
50 | ?24?(49%) | ?16(32%) | 8(16%) | 2(4%) |
(2) relation table 5 of year order and curative effect
The year order | Sum | 25-35 year | 36-46 year | More than 47 years old |
Clinical cure | ???33 | ????5 | ????8 | ????20 |
Produce effects | ???11 | ????2 | ????3 | ????6 |
Effectively | ????4 | ????1 | ????1 | ????2 |
Invalid | ????2 | ????2 |
(3) relation of the course of disease and curative effect: table 6
Curative effect | Sum | More than half a year | More than 1 year | More than 2 years |
Clinical cure | 33 | ????18 | ????8 | ????7 |
Produce effects | 11 | ????8 | ????2 | ????1 |
Effectively | 4 | ????2 | ????1 | ????1 |
Invalid | 2 | ????2 |
Six, safety evaluatio:
Any untoward reaction does not take place at period in a medicine in 50 routine patients.
Seven, model case
Example 1
Sun Honghai, man, 25 years old, after marriage because of impotence, premature ejaculation, soreness of the waist and knees comes to go to a doctor, and haves a medical check-up, and physically well develops, and nutrition is medium, the expression anxiety, the penis NCD, the whole body main organs does not have organic disease, learns that this patient has long-term masturbation, habits of smoking and alcohol drinking history in gathering the medical history process.The tongue fur pitchy, stringy and thready pulse.Diagnosis: sexual neurasthenie.Advise points for attention and oral this product capsule, the acid of conscious waist knee joint is clearly better after the course of treatment, and burning sensation appears in the property tool, and after two courses of treatment, positive group is thought moving, can cross love life during dawn.
Example 2
Li Li, the man, 46 years old, readme libido over one year subtracted greatly, and penis is soft when having sexual intercourse, and difficult the act has a strong impact on normal love life.Have a medical check-up: body development is normal, eutrophy, main organs does not have obvious positive sign, and multinomial biochemical investigation index is the basic normal value that belongs to except that blood fat is slightly higher, learns in the inquiring that have sexual intercourse overfrequency, conjugal relation of patient Ceng You owe harmonious history, diagnosis: sexual neurosis.Advise points for attention: and take this product after three courses of treatment, feeling good, libido is normal.The deficient silk banner one side of sending is to show gratitude.
Embodiment 1
A kind of capsule for the treatment of male sexual hypofunction, it is made to fill a prescription and is: (unit: Kg) Herba Cistanches 1.5 FRUCTUS LYCII 1.5 Fructus Corni 1.5 crust halberds 1.5 Colla cornus cervis 1.5 Radix Rehmanniae Preparata 2.0 field dobbers 1.0 Radix Angelicae Sinensis 1.2 Cortexs Eucommiae 1.2 are fried Leek 1.2 Rhizoma Curculiginises 3.0 Herba Epimedii 3.0 Fructus Cnidiis 1.5 Cortex Cinnamomis 1.0 Radix Rehmanniae 1.0 Radix Achyranthis Bidentataes 1.0 Poria 1.0;
Manufacture method: above-mentioned raw materials is added the octuple decocting for the first time boiled 2 hours, leach decocting liquid, add five times of water for the second time, decoct and leached decocting liquid in 1 hour, add water for the 3rd time and decoct for three times and leached decocting liquid in 1 hour, merges three decocting liquids and concentrating under reduced pressure receipts cream, drying and crushing gets powder, incapsulates.
Embodiment 2
A kind of capsule for the treatment of male sexual hypofunction, it is made to fill a prescription and is: (unit: Kg) Herba Cistanches 1.5 FRUCTUS LYCII 1.5 Fructus Corni 1.5 crust halberds 1.5 Colla cornus cervis 1.5 Radix Rehmanniae Preparata 2.0 field dobbers 1.0
Its manufacture method is with embodiment 1.
Embodiment 3
A kind of capsule for the treatment of male sexual hypofunction, it is made to fill a prescription and is: (unit: Herba Cistanches 1.5 FRUCTUS LYCII 1.5 Fructus Corni 1.5 crust halberds 1.5 Colla cornus cervis 1.5 Radix Rehmanniae Preparata 2.0 field dobbers 1.0 Radix Angelicae Sinensis 1.0 Cortexs Eucommiae 1.0 are fried Leek 1.0 Rhizoma Curculiginises 2.5 Herba Epimedii 2.5 Fructus Cnidiis 1.0 Cortex Cinnamomis 0.8 Radix Rehmanniae 0.8 Radix Achyranthis Bidentatae 0.8 Poria 0.8 Kg);
Its manufacture method is with embodiment 1.
Embodiment 4
A kind of capsule for the treatment of male sexual hypofunction, it is made to fill a prescription and is: (unit: Kg) Herba Cistanches 1.0 FRUCTUS LYCII 1.0 Fructus Corni 1.0 crust halberds 1.0 Colla cornus cervis 1.0 Radix Rehmanniae Preparata 1.5 field dobbers 1.0 Radix Angelicae Sinensis 1.2 Cortexs Eucommiae 1.2 are fried Leek 1.2 Rhizoma Curculiginises 3.0 Herba Epimedii 3.0 Fructus Cnidiis 1.5 Cortex Cinnamomis 1.0 Radix Rehmanniae 1.0 Radix Achyranthis Bidentataes 1.0 Poria 1.0;
Its manufacture method is with embodiment 1.
Claims (3)
1, a kind of capsule for the treatment of male sexual hypofunction is characterized in that: the various compositions of its making prescription are by weight: Herba Cistanches: FRUCTUS LYCII: Fructus Corni: crust halberd: Colla cornus cervi: Radix Rehmanniae Preparata: field dobber=(1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.5-2.0): (0.8-1.0);
2, a kind of capsule for the treatment of male sexual hypofunction according to claim 1 is characterized in that: the various compositions of its making prescription are by weight: saline cistanche: FRUCTUS LYCII: cornus officinalis sieb et zucc: bar halberd: deer horn glue: prepared rhizome of rehmannia: field dobber: Radix Angelicae Sinensis: the bark of eucommia: fry Leek: thizoma curculiginis: HERBA EPIMEDII: frutus cnidii: Chinese cassia tree: radix rehmanniae recen: the root of bidentate achyranthes: Poria cocos=(1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.0-1.5): (1.5-2.0): (0.8-1.0): (1.0-1.2): (1.0-1.2): (1.0-1.2): (2.5-3.0): (2.5-3.0): (1.0-1.5): (0.8-1.0): (0.8-1.0): (0.8-1.0): (0.8-1.0).
3, a kind of capsular manufacture method for the treatment of male sexual hypofunction, it is characterized in that: above-mentioned raw materials is added the octuple decocting for the first time boiled 2 hours, leach decocting liquid, add for the second time five times of water, decoct and leached decocting liquid in 1 hour, add three times in water for the 3rd time and decoct and leached decocting liquid in 1 hour, merges three decocting liquids and concentrating under reduced pressure receipts cream, drying and crushing gets powder, incapsulate.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN98113890A CN1064548C (en) | 1998-04-06 | 1998-04-06 | Capsule for promoting male sexual function and preparation process |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN98113890A CN1064548C (en) | 1998-04-06 | 1998-04-06 | Capsule for promoting male sexual function and preparation process |
Publications (2)
Publication Number | Publication Date |
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CN1231196A true CN1231196A (en) | 1999-10-13 |
CN1064548C CN1064548C (en) | 2001-04-18 |
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CN98113890A Expired - Fee Related CN1064548C (en) | 1998-04-06 | 1998-04-06 | Capsule for promoting male sexual function and preparation process |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102716315A (en) * | 2012-06-29 | 2012-10-10 | 重庆工商大学 | Kidney yang tonifying health care medicinal liquor and preparation method thereof |
CN103656104A (en) * | 2013-12-11 | 2014-03-26 | 山西中医学院 | Application medicine for treating chronic fatigue syndrome and preparation method thereof |
CN107349343A (en) * | 2017-08-31 | 2017-11-17 | 佛山科学技术学院 | A kind of preparation method of health care medicinal liquor for tonifying kidney |
CN111228414A (en) * | 2020-02-02 | 2020-06-05 | 江苏大学 | Health food or Chinese herbal compound for improving male sexual function and ultrasonic preparation method |
CN112603979A (en) * | 2020-12-30 | 2021-04-06 | 马如剑 | Traditional Chinese medicine formula for tonifying kidney and strengthening yang |
CN114053362A (en) * | 2021-11-02 | 2022-02-18 | 董会发 | Composition for tonifying kidney and strengthening yang, preparation method and application of composition in health-care products |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1047939C (en) * | 1993-01-01 | 2000-01-05 | 广州市医药工业研究所 | Compound Chinese patent medicine for treatment of male infertility |
CN1147386A (en) * | 1995-10-10 | 1997-04-16 | 何世珍 | Chinese patent drug for nourishing Yin and strengthening Yang and its prepn |
CN1059921C (en) * | 1997-01-21 | 2000-12-27 | 刘海余 | Tonic yang-strengthening wine |
-
1998
- 1998-04-06 CN CN98113890A patent/CN1064548C/en not_active Expired - Fee Related
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102716315A (en) * | 2012-06-29 | 2012-10-10 | 重庆工商大学 | Kidney yang tonifying health care medicinal liquor and preparation method thereof |
CN102716315B (en) * | 2012-06-29 | 2014-01-15 | 重庆工商大学 | Kidney yang tonifying health care medicinal liquor and preparation method thereof |
CN103656104A (en) * | 2013-12-11 | 2014-03-26 | 山西中医学院 | Application medicine for treating chronic fatigue syndrome and preparation method thereof |
CN107349343A (en) * | 2017-08-31 | 2017-11-17 | 佛山科学技术学院 | A kind of preparation method of health care medicinal liquor for tonifying kidney |
CN111228414A (en) * | 2020-02-02 | 2020-06-05 | 江苏大学 | Health food or Chinese herbal compound for improving male sexual function and ultrasonic preparation method |
CN112603979A (en) * | 2020-12-30 | 2021-04-06 | 马如剑 | Traditional Chinese medicine formula for tonifying kidney and strengthening yang |
CN114053362A (en) * | 2021-11-02 | 2022-02-18 | 董会发 | Composition for tonifying kidney and strengthening yang, preparation method and application of composition in health-care products |
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CN1064548C (en) | 2001-04-18 |
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