CN102327464A - Medicament for treating insomnia - Google Patents
Medicament for treating insomnia Download PDFInfo
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- CN102327464A CN102327464A CN201110302947A CN201110302947A CN102327464A CN 102327464 A CN102327464 A CN 102327464A CN 201110302947 A CN201110302947 A CN 201110302947A CN 201110302947 A CN201110302947 A CN 201110302947A CN 102327464 A CN102327464 A CN 102327464A
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- 239000003814 drug Substances 0.000 title claims abstract description 39
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 20
- 206010022437 insomnia Diseases 0.000 title claims abstract description 17
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 6
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 7
- 241000255791 Bombyx Species 0.000 claims description 5
- 244000293323 Cosmos caudatus Species 0.000 claims description 5
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 5
- 241001312741 Gekko swinhonis Species 0.000 claims description 5
- 239000009286 sanguis draxonis Substances 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 3
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 235000013399 edible fruits Nutrition 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 241000255789 Bombyx mori Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 241001289529 Fallopia multiflora Species 0.000 abstract 1
- 241000533849 Gleditsia Species 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 240000002948 Ophiopogon intermedius Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 241001106477 Paeoniaceae Species 0.000 abstract 1
- 241000907156 Podarcis muralis Species 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000004824 Trimezia steyermarkii Species 0.000 abstract 1
- 235000005272 common selfheal Nutrition 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 230000007958 sleep Effects 0.000 description 14
- 230000001225 therapeutic effect Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 241000201295 Euphrasia Species 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000003860 sleep quality Effects 0.000 description 3
- 230000002618 waking effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001529739 Prunella <angiosperm> Species 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 208000019116 sleep disease Diseases 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 2
- 229960004010 zaleplon Drugs 0.000 description 2
- 206010000125 Abnormal dreams Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 206010029412 Nightmare Diseases 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
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- 239000003213 antiperspirant Substances 0.000 description 1
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- 230000017531 blood circulation Effects 0.000 description 1
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- 238000009835 boiling Methods 0.000 description 1
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- 229940126678 chinese medicines Drugs 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 230000002557 soporific effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
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- 239000006228 supernatant Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicament for treating insomnia. The medicament comprises the following raw material medicaments in part by weight: 10 to 20 parts of glossy privet fruit, 10 to 20 parts of root of rehmannia, 10 to 20 parts of dwarf lilyturf tuber, 10 to 20 parts of spina date seed, 5 to 10 parts of stiff silkworm, 5 to 10 parts of wall lizard, 5 to 10 parts of gleditsia thorn, 5 to 10 parts of eucommia, 5 to 10 parts of polygonum multiflorum, 5 to 10 parts of arillus longan, 10 to 20 parts of common selfheal fruit-spike, 10 to 20 parts of white paeony root, 5 to 10 parts of dragon's blood and 10 to 20 parts of pearl. The medicament has the advantages that: the medicament is formulated after long-term clinical application and adjustment according to basic theories of traditional Chinese medicine and modern pharmacological research of traditional Chinese medicines, and has reasonable compatibility and precise and appropriate using amounts. The medicament belongs to a Chinese medicinal preparation, has a quick effect and an obvious curative effect and has the advantage of eradicating diseases.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of medicine of Cure for insomnia.
Background technology
Insomnia is a kind of common disease, and performance has difficulty falling asleep, sleeps and easy waking up, and this disease makes people's brain can not get abundant rest, and health is tired, has a strong impact on patient's working and learning.Causing the reason of insomnia a lot, mainly is that rhythm of life is accelerated, and operating pressure increases, and psychology, the social factor of striving aspects such as fierceness unexpectedly cause.
At present the Western medicine of Cure for insomnia is main with tranquilizing soporific mainly, and all calmness, hypnotic medicine all produce dependency to some extent, after the drug withdrawal, and symptomatic recurrence, life-time service can develop immunity to drugs.
It is main that the Chinese medicine of Cure for insomnia is mainly calmed the nerves with replenishing blood for nourishing heart, is the Chinese patent of CN1698791A like publication number, is the Chinese patent of CN1706436 like publication number, or the like.Said medicine all has certain curative effect, but it is slow all to have an onset, the shortcoming that need take for a long time.
Summary of the invention
In order to solve the deficiency of above technical elements, the invention provides a kind of rapid-action, evident in efficacy, as can to eradicate the Cure for insomnia of disease advantage medicine that has.
The present invention realizes in the following manner:
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is following:
Fructus Ligustri Lucidi 10-20 part, Radix Rehmanniae 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 10-20 part, Bombyx Batryticatus 5-10 part; Gekko Swinhonis 5-10 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part; Spica Prunellae 10-20 part, Radix Paeoniae Alba 10-20 part, Sanguis Draxonis 5-10 part, Margarita 10-20 part.
Fructus Ligustri Lucidi: liver and kidney tonifying; Clearind deficient heat; Make eye bright.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Semen Ziziphi Spinosae: nourishing the liver, mind calming is calmed the nerves, arresting sweating.
Bombyx Batryticatus: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.
Gekko Swinhonis: dispel the wind, active, eliminating stagnation.
Spina Gleditsiae: suffering, temperature.Return liver, stomach warp, the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Radix Polygoni Multiflori: detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.
Arillus Longan: invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Spica Prunellae: relieving inflammation or internal heat makes eye bright, clearing away liver-fire, blood pressure lowering, mass dissipating and swelling eliminating
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.
Sanguis Draxonis: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.
Margarita: feel at ease, make eye bright.
Beneficial effect of the present invention: medicine of the present invention is according to Basic Theories of Chinese Medicine, Chinese medicine modern pharmacological research, and long-term clinical is worked out with the adjustment back, and compatibility is reasonable, and consumption is precise and appropriate.Medicine of the present invention belongs to pure Chinese medicinal preparation, has rapid-actionly, evident in efficacy, can eradicate the advantage of disease.
The specific embodiment
Embodiment 1
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is following:
10 parts of Fructus Ligustri Lucidi, 20 parts in the Radix Rehmanniae, 10 parts of Radix Ophiopogonis, 20 parts of Semen Ziziphi Spinosaes, 5 parts of Bombyx Batryticatus, 10 parts of Gekko Swinhonis, 5 parts of Spina Gleditsiae, 10 parts of the Cortexs Eucommiae, 5 parts of Radix Polygoni Multiflori, 10 parts of Arillus Longans, 10 parts of Spica Prunellaes, 20 parts of the Radix Paeoniae Albas, 5 parts of Sanguis Draxonis, 20 parts of Margaritas.
Manufacturing method for above mentioned medicine is:
(1) take by weighing raw material in the prescription, place extraction pot, add the water of 8 times of weight, soaked 30 minutes, be heated to water and open back slow fire boiling 2 hours, filter, filtering residue adds 5 times of weight water, repeats above operation, merging filtrate;
(2) filtrating is left standstill, got supernatant, heating is concentrated into relative density 1.10 (60 ℃ of surveys), and spray drying (EAT 160-175 ℃, leaving air temp 85-95 ℃) gets dry extract;
(3) the gained dry extract is put in order with shaking screen, crossed 80 mesh sieves, the gained defective material that will sieve is in addition pulverized with Highefficientpulverizer; Still with the shaking screen arrangement, cross 80 mesh sieves, the gained medicated powder that will sieve merges; Mixed 30 minutes with mixer, be distributed into the 3g/ bag, promptly get after the sterilization.
Usage and consumption: oral, 2 times on the one, each 2 bags.15 days courses of treatment, totally three courses of treatment.
Embodiment 2
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is following:
20 parts of Fructus Ligustri Lucidi, 10 parts in the Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 10 parts of Semen Ziziphi Spinosaes, 10 parts of Bombyx Batryticatus, 5 parts of Gekko Swinhonis, 10 parts of Spina Gleditsiae, 5 parts of the Cortexs Eucommiae, 10 parts of Radix Polygoni Multiflori, 5 parts of Arillus Longans, 20 parts of Spica Prunellaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Sanguis Draxonis, 10 parts of Margaritas.
Method for preparing and usage and dosage are with embodiment 1.
Clinical trial result
1, case data
Accept out-patient's 200 examples for medical treatment, wherein male 88 examples, women 112 examples, age 20-30 year 33 examples, 30-40 year 49 examples, 40-50 year 101 examples, 50-60 year 17 examples.
2, diagnostic criteria
Insomnia belongs to nervous system disease; It is neurosal morbidity performance; On pathomorphology, still can not make sure checking to this type of disease both at home and abroad; The measuring means of also do not have reason, changing goes to confirm criterion of therapeutical effect, can only rely on patient's main suit and the observation of doctor to patient's Signs, makes the foundation of judgement pharmaceutical effectiveness.
3, Therapeutic Method
Of the present invention group: patient's 100 examples, the medicine that uses the embodiment of the invention 1 to make, oral, 2 times on the one, each 2 bags, 15 days courses of treatment, observe three courses of treatment altogether.
Matched group: patient's 100 examples, use to use now and more extensively, generally reflect the Zaleplon tablet that therapeutic effect is good, one time 1, take before sleeping, observed altogether 45 days.
4, efficacy assessment standard
1. cure: reach the length of one's sleep about 7-8 hour;
2. take a turn for the better: increase sleep about 2-3 hour;
3. do not have change: the back of taking medicine is invalid;
4. increase the weight of: the back state of an illness of taking medicine increases the weight of.
5, therapeutic outcome
Following table 1 is of the present invention group of therapeutic outcome statistical table with matched group
Table 1 therapeutic outcome statistical table
| ? | Cure | Take a turn for the better | Do not have and change | Increase the weight of | Effective percentage |
| Of the present invention group | 81 | 19 | 0 | 0 | 100% |
| Matched group | 64 | 24 | 11 | 1 | 88% |
Effective percentage=(cure quantity+improvement quantity)/case sum * 100% wherein.
It is thus clear that medicine of the present invention is compared with the Zaleplon tablet, it is high a lot of that cure rate is wanted, and effective percentage reaches 100%, has no side effect.
The typical clinical case
Case 1: grandson so-and-so, man, 28 years old; IT engineer, the irregular serious insomnia that causes of secular operating pressure and daily schedule shows as 2:00 AM and has difficulty in going to sleep basically before; Can not sleep soundly after sleeping, have a dream again and again, the length of one's sleep of every day is generally about 4 hours; Energy did not recover after sleeping, and once used a variety of Drug therapys, and fruit does not take effect.Use medicine of the present invention after course of treatment, sleep quality obviously improves, and has a dream no longer again and again; Energy is good more a lot of than in the past after waking up, and continues to use medicine of the present invention, after total the 3rd course of treatment; Extend to 7 hours the length of one's sleep, uses again after three courses of treatment, extends to 8 hours the length of one's sleep; Sleep quality obviously improves, and energy is also vigorous, and work efficiency has had large increase.Followed up a case by regular visits to six months, and do not have recurrence.
Case 2: poplar, the woman, 53 years old, be in climacteric, be prone to agitation, often be with anger sleeping, have only 2-3 hour the length of one's sleep, bad dream again and again.Take medicine of the present invention after course of treatment, the length of one's sleep, irritated emotion is eased; Sleep quality has had large increase; No longer often have horrible nightmares, extend to 5 hours the length of one's sleep, continues to use medicine to the of the present invention during four courses of treatment; Can reach 7-8 hour the length of one's sleep, and involutional symptom there be alleviating to a certain degree.Followed up a case by regular visits to six months, and do not have recurrence.
Case 3: the king so-and-so, the woman 38 years old, suffers from insomnia 3 years; Show as difficulty falling asleep, early awakening can't be fallen asleep after waking up again, takes medicine of the present invention after course of treatment; The early awakening symptom is obviously improved, even if early awakening, can also reenter and sleep 1-2 hour; After taking three courses of treatment, reach 7 hours the length of one's sleep, is almost recovered.Followed up a case by regular visits to six months, and do not have recurrence.
It is thus clear that Drug therapy insomnia instant effect of the present invention, therapeutic effect is good, is a kind of medicine that the use prospect is arranged very much.
Claims (1)
1. the medicine of a Cure for insomnia is characterized in that the weight proportion of each crude drug is following:
Fructus Ligustri Lucidi 10-20 part, Radix Rehmanniae 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 10-20 part, Bombyx Batryticatus 5-10 part; Gekko Swinhonis 5-10 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part; Spica Prunellae 10-20 part, Radix Paeoniae Alba 10-20 part, Sanguis Draxonis 5-10 part, Margarita 10-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029474A CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029474A CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102327464A true CN102327464A (en) | 2012-01-25 |
| CN102327464B CN102327464B (en) | 2013-05-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103029474A Active CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
Country Status (1)
| Country | Link |
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| CN (1) | CN102327464B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107319523A (en) * | 2017-06-23 | 2017-11-07 | 天津金匮堂生物科技有限公司 | A kind of insufficiency of heart yin that improves causes health products of insomnia and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679909A (en) * | 2005-01-26 | 2005-10-12 | 陈卫辉 | Chinese medicine composition for treating hyposomnia and preparation thereof |
| CN1973889A (en) * | 2006-11-07 | 2007-06-06 | 任广来 | Insomnia treating Chinese medicine |
-
2011
- 2011-10-10 CN CN2011103029474A patent/CN102327464B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679909A (en) * | 2005-01-26 | 2005-10-12 | 陈卫辉 | Chinese medicine composition for treating hyposomnia and preparation thereof |
| CN1973889A (en) * | 2006-11-07 | 2007-06-06 | 任广来 | Insomnia treating Chinese medicine |
Non-Patent Citations (1)
| Title |
|---|
| 于川: "治疗失眠方剂的配伍规律探析", 《中华中医药学刊》, vol. 25, no. 6, 30 June 2007 (2007-06-30), pages 1204 - 1205 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107319523A (en) * | 2017-06-23 | 2017-11-07 | 天津金匮堂生物科技有限公司 | A kind of insufficiency of heart yin that improves causes health products of insomnia and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN102327464B (en) | 2013-05-15 |
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