CN102327464B - Medicament for treating insomnia - Google Patents
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- CN102327464B CN102327464B CN2011103029474A CN201110302947A CN102327464B CN 102327464 B CN102327464 B CN 102327464B CN 2011103029474 A CN2011103029474 A CN 2011103029474A CN 201110302947 A CN201110302947 A CN 201110302947A CN 102327464 B CN102327464 B CN 102327464B
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- 239000003814 drug Substances 0.000 title claims abstract description 39
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title claims abstract description 20
- 206010022437 insomnia Diseases 0.000 title claims abstract description 17
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 6
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 7
- 241000255791 Bombyx Species 0.000 claims description 5
- 244000293323 Cosmos caudatus Species 0.000 claims description 5
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 5
- 241001312741 Gekko swinhonis Species 0.000 claims description 5
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- 210000000582 semen Anatomy 0.000 claims description 5
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 3
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- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
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- 235000005272 common selfheal Nutrition 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000007958 sleep Effects 0.000 description 14
- 230000001225 therapeutic effect Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
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- 241000201295 Euphrasia Species 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000533849 Gleditsia Species 0.000 description 2
- 241001529739 Prunella <angiosperm> Species 0.000 description 2
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- HUNXMJYCHXQEGX-UHFFFAOYSA-N zaleplon Chemical compound CCN(C(C)=O)C1=CC=CC(C=2N3N=CC(=C3N=CC=2)C#N)=C1 HUNXMJYCHXQEGX-UHFFFAOYSA-N 0.000 description 2
- 229960004010 zaleplon Drugs 0.000 description 2
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicines, in particular to a medicament for treating insomnia. The medicament comprises the following raw material medicaments in part by weight: 10 to 20 parts of glossy privet fruit, 10 to 20 parts of root of rehmannia, 10 to 20 parts of dwarf lilyturf tuber, 10 to 20 parts of spina date seed, 5 to 10 parts of stiff silkworm, 5 to 10 parts of wall lizard, 5 to 10 parts of spina gleditsiae, 5 to 10 parts of eucommia, 5 to 10 parts of polygonum multiflorum, 5 to 10 parts of arillus longan, 10 to 20 parts of common selfheal fruit-spike, 10 to 20 parts of white paeony root, 5 to 10 parts of dragon's blood and 10 to 20 parts of pearl. The medicament has the advantages that: the medicament is formulated after long-term clinical application and adjustment according to basic theories of traditional Chinese medicine and modern pharmacological research of traditional Chinese medicines, and has reasonable compatibility and precise and appropriate using amounts. The medicament belongs to a Chinese medicinal preparation, has a quick effect and an obvious curative effect and has the advantage of eradicating diseases.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly a kind of medicine of Cure for insomnia.
Background technology
Insomnia is a kind of common disease, and performance has difficulty falling asleep, sleeps and easily awake, and this disease makes people's brain can not get abundant rest, and health is tired, has a strong impact on patient's working and learning.Causing the reason of insomnia a lot, is mainly that rhythm of life is accelerated, and operating pressure increases, and psychology, the social factor of unexpectedly striving the aspects such as fierceness cause.
The Western medicine of present Cure for insomnia is mainly take tranquilizing soporific as main, and the medicine of all calmness, hypnosis all produces dependency to some extent, after drug withdrawal, and symptomatic recurrence, life-time service can develop immunity to drugs.
The Chinese medicine of Cure for insomnia is mainly calmed the nerves as main take replenishing blood for nourishing heart, is the Chinese patent of CN1698791A as publication number, is the Chinese patent of CN1706436 as publication number, etc.Said medicine all has certain curative effect, but it is slow all to have an onset, needs the shortcoming of long-term taking.
Summary of the invention
In order to solve the deficiency of above technical elements, the invention provides a kind of rapid-action, evident in efficacy, as can to eradicate the Cure for insomnia of disease advantage medicine that has.
The present invention is achieved in the following ways:
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is as follows:
Fructus Ligustri Lucidi 10-20 part, Radix Rehmanniae 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 10-20 part, Bombyx Batryticatus 5-10 part, Gekko Swinhonis 5-10 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part, Spica Prunellae 10-20 part, Radix Paeoniae Alba 10-20 part, Sanguis Draxonis 5-10 part, Margarita 10-20 part.
Fructus Ligustri Lucidi: liver and kidney tonifying; Clearind deficient heat; Make eye bright.
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Semen Ziziphi Spinosae: nourishing the liver, mind calming is calmed the nerves, arresting sweating.
Bombyx Batryticatus: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.
Gekko Swinhonis: dispel the wind, active, eliminating stagnation.
Spina Gleditsiae: suffering, temperature.Return liver, stomach warp, the evacuation of pus of drawing out pus by applying a plaster to the affected part, promoting blood circulation and detumescence.
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Radix Polygoni Multiflori: detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.
Arillus Longan: invigorating the heart and spleen, nourishing blood to tranquillize the mind.
Spica Prunellae: relieving inflammation or internal heat makes eye bright, clearing away liver-fire, blood pressure lowering, mass dissipating and swelling eliminating
The Radix Paeoniae Alba: nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.
Sanguis Draxonis: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.
Margarita: feel at ease, make eye bright.
Beneficial effect of the present invention: medicine of the present invention is according to Basic Theories of Chinese Medicine, Chinese medicine modern pharmacological research, works out after long-term clinical application and adjustment, and compatibility is reasonable, and consumption is precise and appropriate.Medicine of the present invention belongs to pure Chinese medicinal preparation, has rapid-actionly, evident in efficacy, can eradicate the advantage of disease.
The specific embodiment
Embodiment 1
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is as follows:
10 parts of Fructus Ligustri Lucidi, 20 parts, the Radix Rehmanniae, 10 parts of Radix Ophiopogonis, 20 parts of Semen Ziziphi Spinosaes, 5 parts of Bombyx Batryticatus, 10 parts of Gekko Swinhonis, 5 parts of Spina Gleditsiaes, 10 parts of the Cortexs Eucommiae, 5 parts of Radix Polygoni Multiflori, 10 parts of Arillus Longans, 10 parts of Spica Prunellaes, 20 parts of the Radix Paeoniae Albas, 5 parts of Sanguis Draxonis, 20 parts of Margaritas.
The preparation method of said medicine is:
(1) take raw material in prescription, be placed in extraction pot, add the water of 8 times of weight, soaked 30 minutes, be heated to water and open rear slow fire boiling 2 hours, filter, filtering residue adds 5 times of weight water, repeats above operation, merging filtrate;
(2) filtrate is standing, get supernatant, heating is concentrated into relative density 1.10(60 ℃ survey), spray drying (inlet temperature 160-175 ℃, leaving air temp 85-95 ℃) gets dry extract;
(3) the gained dry extract is arranged with shaking screen, cross 80 mesh sieves, the gained defective material that separately will sieve is pulverized with Highefficientpulverizer, still arrange with shaking screen, cross 80 mesh sieves, the gained medicated powder that will sieve merges, mixed 30 minutes with mixer, be distributed into the 3g/ bag, after sterilization and get final product.
Usage and consumption: oral, 2 times on the one, each 2 bags.15 days courses for the treatment of, totally three courses for the treatment of.
Embodiment 2
A kind of medicine of Cure for insomnia, the weight proportion of each crude drug is as follows:
20 parts of Fructus Ligustri Lucidi, 10 parts, the Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 10 parts of Semen Ziziphi Spinosaes, 10 parts of Bombyx Batryticatus, 5 parts of Gekko Swinhonis, 10 parts of Spina Gleditsiaes, 5 parts of the Cortexs Eucommiae, 10 parts of Radix Polygoni Multiflori, 5 parts of Arillus Longans, 20 parts of Spica Prunellaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Sanguis Draxonis, 10 parts of Margaritas.
Preparation method and usage and dosage are with embodiment 1.
Clinical trial result
1, case-data
Accept out-patient's 200 examples for medical treatment, male 88 examples wherein, female's 112 examples, age 20-30 year 33 examples, 30-40 year 49 examples, 40-50 year 101 examples, 50-60 year 17 examples.
2, diagnostic criteria
Insomnia belongs to nervous system disease, it is neurosal morbidity performance, still can not make sure checking to this type of disease on pathomorphology both at home and abroad, the measuring means of also there is no reason, changing goes to determine criterion of therapeutical effect, can only rely on patient's main suit and doctor to the observation of patient's Signs, judge the foundation of pharmaceutical effectiveness.
3, Therapeutic Method
Of the present invention group: patient's 100 examples, the medicine that uses the embodiment of the present invention 1 to make, oral, 2 times on the one, each 2 bags, 15 days courses for the treatment of, observe altogether three courses for the treatment of.
Matched group: patient's 100 examples, use present usage comparison extensively, generally to reflect the Zaleplon tablet that therapeutic effect is good, one time 1, take before sleeping, observed altogether 45 days.
4, efficacy assessment standard
1. cure: reach the length of one's sleep about 7-8 hour;
2. take a turn for the better: increase sleep about 2-3 hour;
3. without changing: take medicine rear invalid;
4. increase the weight of: the rear aggravation of taking medicine.
5, therapeutic outcome
Following table 1 is the therapeutic outcome statistical table of of the present invention group and matched group
Table 1 therapeutic outcome statistical table
| ? | Cure | Take a turn for the better | Without changing | Increase the weight of | Effective percentage |
| Of the present invention group | 81 | 19 | 0 | 0 | 100% |
| Matched group | 64 | 24 | 11 | 1 | 88% |
Effective percentage=(cure quantity+improvement quantity)/case sum * 100% wherein.
As seen, medicine of the present invention is compared with the Zaleplon tablet, and it is high a lot of that cure rate is wanted, and effective percentage reaches 100%, has no side effect.
The typical clinical case
Case 1: grandson so-and-so, the man, 28 years old, IT engineer, the irregular serious insomnia that causes of long-term operating pressure and daily schedule, substantially have difficulty in going to sleep before showing as 2:00 AM, can not sleep soundly after falling asleep, again and again have a dream, the length of one's sleep of every day is generally about 4 hours, after sleeping, energy did not recover, and once used a variety of Drug therapys, had no effect.Use medicine of the present invention after course for the treatment of, sleep quality obviously improves, and no longer again and again has a dream, and after waking up, energy is than good a lot of in the past, continue to use medicine of the present invention, after total the 3rd course for the treatment of, extend to 7 hours the length of one's sleep, after using again three courses for the treatment of, extend to 8 hours the length of one's sleep, sleep quality obviously improves, and energy is also vigorous, and work efficiency has had large increase.Followed up a case by regular visits to six months, without recurrence.
Case 2: poplar, the female, 53 years old, be in climacteric, easily irritated, often fall asleep with anger, only have 2-3 hour the length of one's sleep, bad dream again and again.Take medicine of the present invention after course for the treatment of, the length of one's sleep, irritated emotion is eased, sleep quality has had large increase, no longer often have horrible nightmares, extend to 5 hours the length of one's sleep, continues to use medicine to the of the present invention during four courses for the treatment of, can reach 7-8 hour the length of one's sleep, and involutional symptom there be alleviating to a certain degree.Followed up a case by regular visits to six months, without recurrence.
Case 3: the king so-and-so, female, 38 years old, suffer from insomnia 3 years, show as difficulty falling asleep, early awakening, can't fall asleep again after waking up, take medicine of the present invention after course for the treatment of, the early awakening symptom is obviously improved, even if early awakening, can also reenter and sleep 1-2 hour, after taking three courses for the treatment of, reach 7 hours the length of one's sleep, is almost recovered.Followed up a case by regular visits to six months, without recurrence.
As seen Drug therapy of the present invention insomnia instant effect, therapeutic effect is good, is a kind of medicine that prospect of the application is arranged very much.
Claims (1)
1. the medicine of a Cure for insomnia is characterized in that the weight proportion of each crude drug is as follows:
Fructus Ligustri Lucidi 10-20 part, Radix Rehmanniae 10-20 part, Radix Ophiopogonis 10-20 part, Semen Ziziphi Spinosae 10-20 part, Bombyx Batryticatus 5-10 part, Gekko Swinhonis 5-10 part, Spina Gleditsiae 5-10 part, Cortex Eucommiae 5-10 part, Radix Polygoni Multiflori 5-10 part, Arillus Longan 5-10 part, Spica Prunellae 10-20 part, Radix Paeoniae Alba 10-20 part, Sanguis Draxonis 5-10 part, Margarita 10-20 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029474A CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103029474A CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102327464A CN102327464A (en) | 2012-01-25 |
| CN102327464B true CN102327464B (en) | 2013-05-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103029474A Active CN102327464B (en) | 2011-10-10 | 2011-10-10 | Medicament for treating insomnia |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107319523A (en) * | 2017-06-23 | 2017-11-07 | 天津金匮堂生物科技有限公司 | A kind of insufficiency of heart yin that improves causes health products of insomnia and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679909A (en) * | 2005-01-26 | 2005-10-12 | 陈卫辉 | Chinese medicine composition for treating hyposomnia and preparation thereof |
| CN100425274C (en) * | 2006-11-07 | 2008-10-15 | 任广来 | Insomnia treating Chinese medicine |
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