CN104958593A - Traditional Chinese medicine for treating damp heat type infertility and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating damp heat type infertility and a preparation method thereof. All raw medicinal materials of the traditional Chinese medicine comprise coriandrum sativum, stellaria yunnanensis, bergamot, strobilanthes sarcorrhizus cling, black soyabean, petelot habenaria, root and rhizome of divaricate gynura, chirita fimbrisepala hand, all-grass of balanophora involucrata hook, root of featherycleft horsegentian, setaria viridis, cirsium setosum, paraphlonia, osbeckia opipara, dioscorea hemsleyi, mulberry gall-midge, denseflower bulbophyllum herb and common coltsfoot flower. The traditional Chinese medicine for treating the damp heat type infertility, provided by the invention, has the advantages of safety in use, no toxic or side effect, no anaphylactic reaction, short cycle, high cure rate and convenience in use.

Description

A kind ofly treat infertile Chinese medicine of damp-heat type and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating infertile Chinese medicine of damp-heat type and preparation method thereof.

Background technology

Infertility refers to woman's matrimonial cohabitation more than 2 years after marriage, and syngamy function is normal, does not practise contraception and the person of not becoming pregnant, or once bred, do not practise contraception and more than the 2 years persons that do not become pregnant again, be called " infertility ", the former is called " primary infertility ", and the latter is called " secondary infertility ".Gu claims the former to be " entirely not producing ", and the latter is " breaks ".Etiology and pathogenesis: men and women contain in kidney qi, the menarche, under the condition of abundant CHONG meridian with unobstructed REN meridian, woman's regular menstrual cycle, man's spermatic ejeculation, both sexes are harmonious, and it is pregnant just can to reach agreement into tire, and visible infertile main and deficiency of kidney-QI, punching appoints disorder of QI and blood relevant.Clinically commonly to suffer from a deficiency of the kidney, the type such as stagnation of liver-QI, phlegm-damp, blood stasis.

Infertile differentiation of symptoms and signs for classification of syndrome is following type by the traditional Chinese medical science:

Renal deficiency type: card is shown in delayed period or amenorrhea, rare through the few light matter of color of row amount, accompany dizzy tinnitus, soreness of the waist and knees, hyposexuality, pale tongue with thin fur, deep-thready pulse.

Liver energy stagnation type: card is shown in delayed menstrual cycle or successively irregular, or amenorrhea, does swollen through fore udder, or lower abdominal distention pain, blockage of menstruation, or holds clot under the arm, accompanies sigh uncomfortable in chest, susceptible to lose temper due to restlessness, red tongue with thin fur, thready and stringy pulse.

Blood stasis type: card is shown in delayed menstrual cycle, or amenorrhea, through the few abdomen pain of row, dark menses folder clot, few time many during amount, blockage of menstruation, or dripping unclean, tongue limit purple is dim, thready and hesitant pulse.

Phlegm stagnation syndrome type: card is shown in delayed menstrual cycle, or amenorrhea, few through row amount, the light matter of color is rare, accompanies painful abdominal mass uncomfortable in chest to hinder, abundant expectoration nausea, dizzy drowsiness, obesity, or breast galactorrhea, and tongue is greasy in vain, and tongue body is fat, and moderate pulse is sliding.Treatment adopts dissipating phlegm and resolving masses method.

Damp-heat type: card is shown in that menstruation is successively irregularly, and many through the dim red amount of color, matter is stained with dirty taste, or leukorrhagia is red mixes mutually in vain, or muddiness is as water from washing rice, red tongue with yellowish and greasy fur, soft and rapid pulse.

Summary of the invention:

Technical problem to be solved by this invention is, utilizes the theory of Chinese medical science that China is traditional, provides a kind of and treats infertile Chinese medicine of damp-heat type and preparation method thereof, Chinese medicine use safety of the present invention, has no side effect, and the cycle of curing is short, and therapeutic effect is good.

In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat the infertile Chinese medicine of damp-heat type, its raw medicinal material comprises: Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae, Balanophora dioica R Br ex Royle, Radix Triostei Pinnatifidi, Herba Setariae Viridis, Herba Cirsii, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, Radix Osbeckiae Crinitae, Radix dioscoreae subcalvae, Nodus Mori, Herba Bulbophylli Odoratissim and Flos Farfarae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Coriandri 20 ~ 30 parts, Radix Stellariae Yunnanensis 10 ~ 20 parts, Fructus Citri Sarcodactylis 10 ~ 20 parts, Strobilanthes sarcorrhizus Cling 20 ~ 30 parts, Semen sojae atricolor 15 ~ 25 parts, Herba Habenariae rhodochellae 8 ~ 18 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 30 parts, Rhizoma Chiritae Fimbrisepalae 10 ~ 20 parts, Balanophora dioica R Br ex Royle 22 ~ 32 parts, Radix Triostei Pinnatifidi 25 ~ 35 parts, Herba Setariae Viridis 10 ~ 20 parts, Herba Cirsii 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, Radix Osbeckiae Crinitae 20 ~ 30 parts, Radix dioscoreae subcalvae 15 ~ 25 parts, Nodus Mori 5 ~ 15 parts, Herba Bulbophylli Odoratissim 23 ~ 33 parts and Flos Farfarae 18 ~ 28 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Coriandri 25 ~ 30 parts, Radix Stellariae Yunnanensis 15 ~ 20 parts, Fructus Citri Sarcodactylis 12 ~ 17 parts, Strobilanthes sarcorrhizus Cling 23 ~ 28 parts, Semen sojae atricolor 17 ~ 22 parts, Herba Habenariae rhodochellae 11 ~ 16 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 25 parts, Rhizoma Chiritae Fimbrisepalae 13 ~ 18 parts, Balanophora dioica R Br ex Royle 24 ~ 29 parts, Radix Triostei Pinnatifidi 28 ~ 33 parts, Herba Setariae Viridis 12 ~ 17 parts, Herba Cirsii 15 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 ~ 30 parts, Radix Osbeckiae Crinitae 23 ~ 28 parts, Radix dioscoreae subcalvae 17 ~ 22 parts, Nodus Mori 8 ~ 13 parts, Herba Bulbophylli Odoratissim 26 ~ 31 parts and Flos Farfarae 21 ~ 26 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Coriandri 28 parts, Radix Stellariae Yunnanensis 16 parts, Fructus Citri Sarcodactylis 16 parts, Strobilanthes sarcorrhizus Cling 24 parts, Semen sojae atricolor 21 parts, Herba Habenariae rhodochellae 12 parts, Radix et Rhizoma Gynurae divaricatae 24 parts, Rhizoma Chiritae Fimbrisepalae 14 parts, Balanophora dioica R Br ex Royle 28 parts, Radix Triostei Pinnatifidi 29 parts, Herba Setariae Viridis 16 parts, Herba Cirsii 17 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 28 parts, Radix Osbeckiae Crinitae 24 parts, Radix dioscoreae subcalvae 21 parts, Nodus Mori 9 parts, Herba Bulbophylli Odoratissim 30 parts and Flos Farfarae 22 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Coriandri 25 parts, Radix Stellariae Yunnanensis 18 parts, Fructus Citri Sarcodactylis 13 parts, Strobilanthes sarcorrhizus Cling 27 parts, Semen sojae atricolor 19 parts, Herba Habenariae rhodochellae 15 parts, Radix et Rhizoma Gynurae divaricatae 22 parts, Rhizoma Chiritae Fimbrisepalae 17 parts, Balanophora dioica R Br ex Royle 25 parts, Radix Triostei Pinnatifidi 32 parts, Herba Setariae Viridis 13 parts, Herba Cirsii 19 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 26 parts, Radix Osbeckiae Crinitae 26 parts, Radix dioscoreae subcalvae 20 parts, Nodus Mori 12 parts, Herba Bulbophylli Odoratissim 29 parts and Flos Farfarae 25 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae and Balanophora dioica R Br ex Royle mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to damp-heat type is infertile, and toxic and side effects is little, easy to use, the cycle of curing is short.

Detailed description of the invention

The invention provides and a kind ofly treat the infertile Chinese medicine of damp-heat type, its raw medicinal material comprises: Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae, Balanophora dioica R Br ex Royle, Radix Triostei Pinnatifidi, Herba Setariae Viridis, Herba Cirsii, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, Radix Osbeckiae Crinitae, Radix dioscoreae subcalvae, Nodus Mori, Herba Bulbophylli Odoratissim and Flos Farfarae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Coriandri: [another name] Herba Coriandri, coriander, Caulis et Folium Brassicae campestris, former Sui, garden Sui, coriander, Herba Coriandri, tabernaemontanus bulrush Sui, Yan Sui Cai, Yan Pueraria lobota grass, Caulis et folium pavettae hongkongensis.[source] medical material Ji Yuan: be the whole herb with root of samphire coriander.Latin plant animal mineral name: Coriandrum sativum L.[nature and flavor] acrid in the mouth; Warm in nature.[return through] returns lung; Spleen; Liver Channel.[function cures mainly] delivers rash; Digesting and appetizing; Analgesic antidotal.Main anemofrigid cold; Measles; Varioliform exanthema is sent out not smooth thoroughly; Containing food stagnation; Abdominal distention; Vomiting and nausea; Headache; Toothache; Proctoptosis; Erysipelas; Skin ulcer swollen from the beginning of; Snakebite.[extracts] " China's book on Chinese herbal medicine "

Radix Stellariae Yunnanensis: [another name] wheat ginseng, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), little fat medicine.[source] medical material Ji Yuan: be the root of pinkwort Yunnan Herba stellariae mediae.Latin plant animal mineral name: Stellaria yunnanensisFranch.[nature and flavor] are sweet; Property is put down.[return through] liver; Spleen; Kidney channel.[function cures mainly] strengthening spleen and nourishing blood; The liver and the kidney tonifying; Detumescence.Main anemia; Spirit is deficient; Dizzy nervous; Tinnitus dim eyesight; Hectic fever; Seminal emission; Menoxenia; Leukorrhagia; Fracture; Mastitis.[extracts] " China's book on Chinese herbal medicine "

Fructus Citri Sarcodactylis: [another name] Fructus Citri Sarcodactylis, Bergamot, Mi Dong Citrus chachiensis Hort., Fructus Citri Sarcodactylis, Fu Shou Citrus chachiensis Hort., Folium vilicis Negundo, hands Citrus chachiensis Hort..[source] medical material Ji Yuan: be the fruit of rutaceae Fructus Citri Sarcodactylis.[nature and flavor] are pungent; Bitter; Temperature.[return through] liver; Stomach; Spleen; Lung meridian.[function cures mainly] liver-smoothing, qi-regulating; Stomach function regulating reduces phlegm.Hypochondriac pain, the breast of main depression of liver-QI are vexed; The abdominal distention of incoordination between the liver and stomach, stagnation of QI in spleen and stomach, heating installation, to feel sick; Chronic cough abundant expectoration.[extracts] " China's book on Chinese herbal medicine "

Strobilanthes sarcorrhizus Cling: [another name] native Radix Pseudostellariae, meat root Acanthaceous indigo.[source] medical material Ji Yuan: be root or the herb of acanthaceous plant Strobilanthes sarcorrhizus Cling.[nature and flavor] sweet in the mouth; Micro-hardship; Cool in nature.[return through] returns kidney; Stomach warp.[function cures mainly] tonifying kidney and nourishing yin; Heat-clearing and toxic substances removing.Main kidney tiger lumbago; Tiger pyretic toothache; Hepatitis; Furuncle furuncle and phyma.[extracts] " China's book on Chinese herbal medicine "

Semen sojae atricolor: [another name] black bean, Semen sojae atricolor, winter bean, Semen sojae atricolor, bean.[source] medical material Ji Yuan: be the black seeds of legume soybean.Latin plant animal mineral name: Glycine max (L.) Merr. [Phaseolus max L.].[nature and flavor] are sweet; Flat.[return through] spleen; Kidney; Heart channel.[function cures mainly] activating blood and promoting diuresis; To dispel the wind removing toxic substances; Tonifying speen and tonifying kidney.Main edema distension; Pathogenic wind-toxic beriberi; Jaundice edema; Lumbago due to renal deficiency; The enuresis; Migratory arthralgia clonic spasm of the muscle; Puerperal puerperal tetanus; Locked mouth; Carbuncle sore tumefacting virus; Medicine, alimentary toxicosis.[extracts] " China's book on Chinese herbal medicine "

Herba Habenariae rhodochellae: [source] medical material Ji Yuan: be the herb of the beautiful phoenix flower of the narrow lobe of orchid.Latin plant animal mineral name: Habenaria stenopetala Lindl.[nature and flavor] are sweet; Light; Property is put down.[return through] kidney; Urinary bladder channel.[function cures mainly] kidney invigorating and YANG supporting.Main sexual impotence; Hernia.[extracts] " China's book on Chinese herbal medicine "

Radix et Rhizoma Gynurae divaricatae: [another name] large cattle, Hypoestes purpurea, the dish that clears away heart-fire, divaricate gynura root and rhizome, white young dish medicine, loose blood Rhizoma Zingiberis Recens, Rhizoma Stahlianthi Involucrati, white blood skin dish, HUDOU seven, Anotis wightiana (Wall.) Hook.F., Sedum aizoon L., roller, of heap of stonely to rescue, Herba Gynurae Divaricatae, stone Radix Notoginseng, tree Radix Notoginseng, large greenery, Cortex torricelliae tiliifoliae, beautiful Folium Eriobotryae, spun gold Folium Eriobotryae, Bai Dongfeng, thick dough cover, chicken dish, white kind of Herba Amaranthi tricoloris, white Herba Gynurae bicoloris, furuncle pull out, pitch colored Radix Notoginseng, large dizzy sick medicine.[source] medical material Ji Yuan: be the herb of feverfew Gynura divaricata.[nature and flavor] acrid in the mouth; Light; Property is put down.[function cures mainly] clearing away heat and cooling blood; Promoting blood circulation and stopping pain; Hemostasis.Main cough; Skin infection; Scald scorching wound; Traumatic injury; Rheumatalgia; Metrorrhagia; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "

Rhizoma Chiritae Fimbrisepalae: [another name] Elatostema monandrum (D. Don) Hara-Procris monan-drum D. Don, stone Scolopendra, red Rhizoma Chiritae Fimbrisepalae, asbestos, Rhizoma Seu Herba Bergeniae [changde, hunan].[source] Gesneriaceae Chirita plant Rhizoma Chiritae Fimbrisepalae, is used as medicine with root stock.The whole year can adopt, and dries.[nature and flavor] are bitter, cool.[function cures mainly] strengthening the spleen to promote digestion, clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.For infantile malnutrition, stomachache, hepatitis, dysentery, hemoptysis of pulmonary tuberculosis; It is hemorrhage that knife injury is controlled in external, innominate toxic swelling, traumatic injury.[extracts] " national Chinese herbal medicine compilation "

Balanophora dioica R Br ex Royle: [another name] does not go up lotus, exceedingly high wax candle, Shi Shanglian, mountain Fructus Ananadis comosi.[source] medical material Ji Yuan: be the Herb of Balanophoraceae plant flower thinning Balaenoptera borealis Lesson.[nature and flavor] are bitter; Cool in nature.The yin nourishing of [function cures mainly] kidney tonifying; Clearing away heat to stop bleeding.Main lumbago due to renal deficiency; Asthenia is hemorrhage; Bleeding hemorrhoids.[extracts] " China's book on Chinese herbal medicine "

Radix Triostei Pinnatifidi: [another name] Semen Ginkgo seven, chicken feet seven.[source] medical material Ji Yuan: be the root of the caprifoliaceae plant stem of a herb Fischer.[nature and flavor] bitter in the mouth; Property is put down.[function cures mainly] expelling wind and removing dampness; Promoting flow of QI and blood; Help digestion.Main lumbago, skelalgia of rheumatism; Impairment caused by overstrain; Traumatic injury; Menoxenia; Food stagnation.[extracts] " China's book on Chinese herbal medicine "

Herba Setariae Viridis: [another name] green bristlegrass, green bristlegrass grass seed, green bristlegrass grass, bright grass, Buddhism arhat, arahat, or arahant are careless, half, Canis familiaris L. tail, paddy green bristlegrass, wash grass, large tail grass, large caudal flexure, hair doll, hair too, Mao Maocao.[source] medical material Ji Yuan: be the herb of grass Herba Setariae Viridis.[nature and flavor] sweet in the mouth; Light; Cool in nature.[return through] heart; Liver Channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Dispelling pathogenic wind for improving eyesight; Removing toxic substances; Parasite killing.Main anemopyretic cold; Jaundice; Infantile malnutrition; Dysentery; Difficulty and pain in micturition; The puckery pain of conjunctival congestion; Conjunctival congestion and swelling pain; Carbuncle; Verruca vulgaris; Skin ulcer tinea.[extracts] " China's book on Chinese herbal medicine "

Herba Cirsii: [another name] cat Ji, blue or green field thistle, thousand needle grass, field thistle dish, field thistle, blue and green dish, luxuriant dish, rifle cutter dish, wild Flos Carthami, thorn angle dish, wood thorn Chinese mugwort, thorn stick dish, thorn spinoblast, assassination grass, shepherd's purse shepherd's purse hair, little evil hen, Ci Luobu, Herba Cirsii nurse, oriental dodartia herb, cattle jab, sting tip grass, spinule lid.[source] medical material Ji Yuan: be herb or the root of feverfew field thistle.[nature and flavor] sweet in the mouth; Micro-hardship; Cool in nature.[return through] returns liver; Spleen channel.[function cures mainly] cooling blood for hemostasis; Clearing heat for detumescence.Main hemoptysis; Spit blood; Epistaxis; Hematuria; Stranguria with blood; Have blood in stool; Dysentery; Metrorrhagia and metrostaxis; Traumatic hemorrhage; Swollen ulcer drug.[extracts] " China's book on Chinese herbal medicine "

Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu: [another name] native nine uncompleted buildings, large pellet in a shotgun cartridge dish, tall bottle with spout flower.[source] medical material Ji Yuan: be root or the herb of the false Herba phlomidis of labiate lobule.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] is nourshing Yin and drynsessmoistening prescription; Cough-relieving; Regulating menstruation.Main deficiency of YIN chronic cough; Sputum mixed with blood; Menoxenia.[extracts] " China's book on Chinese herbal medicine "

Radix Osbeckiae Crinitae: [another name] is to sky calabash, bottle grass, sub, the cat ear of tank switching.The fragrant platymiscium Radix Osbeckiae Crinitae Osbeckia crinita Benth.ex Wall. of [source] Melastomataceae brocade, is used as medicine with root and fruit.Autumn uproots, and plucks infructescence, cleans and dries.[nature and flavor] are sweet, puckery, flat.[function cures mainly] clearing away heat-damp and promoting diuresis, cough-relieving, regulating menstruation.For acute gastroenteritis, bacillary dysentery, dyspepsia, chronic bronchitis, spits blood, menoxenia, leucorrhea.[extracts] " national Chinese herbal medicine compilation "

Radix dioscoreae subcalvae: [another name] Dioscorea subcalva Prain et Burhll, sticky Canis familiaris L. sweet potato.[source] Dioscoreaceae yam Radix dioscoreae subcalvae, is used as medicine with tuber.Autumn and winter excavate, and clean and dry.[nature and flavor] are sweet, flat.[function cures mainly] invigorating the spleen to clear away damp pathogen, invigorating the lung and the kidney.For pulmonary tuberculosis, diarrhea due to hypofunction of the spleen, quenches one's thirst; Traumatic injury is controlled in external.[extracts] " national Chinese herbal medicine compilation "

Nodus Mori: [source] medical material Ji Yuan: be the tuberosity on moraceae plants Mulberry veteran.Latin plant animal mineral name: Morus alba L.Gather and store: when winter, mulberry was pruned, sawing the warty tuberosity got on old mulberry, be split into irregular fritter sheet when taking advantage of fresh, dry.[nature and flavor] are bitter; Property is put down.[return through] liver; Stomach warp.[function cures mainly] dispels the wind except temperature; Pain relieving; Detumescence.Main air temperature arthralgia pain; Stomachache; The arthroncus of knee.[extracts] " China's book on Chinese herbal medicine "

Herba Bulbophylli Odoratissim: [another name] little Herba Bulbophylli Odoratissim, Bulbophyllum calodictyon schlecht., extremely fragrant Bulbophyllum, elaeagnus conferta fruits.[source] medical material Ji Yuan: be the herb of orchid Bulbophyllum odoratissimum Lindl..[nature and flavor] are sweet; Light; Cool.[return through] lung; Liver; Kidney channel.[function cures mainly] moistening the lung and resolving phlegm; Removing obstruction in the collateral to relieve pain.Main hemoptysis of pulmonary tuberculosis; Chronic tracheitis; Chronic pharyngitis; Hernia pain; Menoxenia; Rheumatic arthralgia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Flos Farfarae: [another name] Flos Farfarae, money flower, see snuff, Ai Donghua, 99 flower.[source] medical material Ji Yuan: be the alabastrum of feverfew coltsfoot.[nature and flavor] acrid in the mouth; Micro-sweet; Warm in nature.[return through] returns lung meridian.[function cures mainly] nourishing the lung to keep the adverse QI downward; Preventing phlegm from forming and stopping coughing.Main new chronic cough is coughed; Asthma; Chronic cough hemoptysis.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Coriandri 20 ~ 30 parts, Radix Stellariae Yunnanensis 10 ~ 20 parts, Fructus Citri Sarcodactylis 10 ~ 20 parts, Strobilanthes sarcorrhizus Cling 20 ~ 30 parts, Semen sojae atricolor 15 ~ 25 parts, Herba Habenariae rhodochellae 8 ~ 18 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 30 parts, Rhizoma Chiritae Fimbrisepalae 10 ~ 20 parts, Balanophora dioica R Br ex Royle 22 ~ 32 parts, Radix Triostei Pinnatifidi 25 ~ 35 parts, Herba Setariae Viridis 10 ~ 20 parts, Herba Cirsii 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, Radix Osbeckiae Crinitae 20 ~ 30 parts, Radix dioscoreae subcalvae 15 ~ 25 parts, Nodus Mori 5 ~ 15 parts, Herba Bulbophylli Odoratissim 23 ~ 33 parts and Flos Farfarae 18 ~ 28 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Coriandri 25 ~ 30 parts, Radix Stellariae Yunnanensis 15 ~ 20 parts, Fructus Citri Sarcodactylis 12 ~ 17 parts, Strobilanthes sarcorrhizus Cling 23 ~ 28 parts, Semen sojae atricolor 17 ~ 22 parts, Herba Habenariae rhodochellae 11 ~ 16 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 25 parts, Rhizoma Chiritae Fimbrisepalae 13 ~ 18 parts, Balanophora dioica R Br ex Royle 24 ~ 29 parts, Radix Triostei Pinnatifidi 28 ~ 33 parts, Herba Setariae Viridis 12 ~ 17 parts, Herba Cirsii 15 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 ~ 30 parts, Radix Osbeckiae Crinitae 23 ~ 28 parts, Radix dioscoreae subcalvae 17 ~ 22 parts, Nodus Mori 8 ~ 13 parts, Herba Bulbophylli Odoratissim 26 ~ 31 parts and Flos Farfarae 21 ~ 26 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Coriandri 28 parts, Radix Stellariae Yunnanensis 16 parts, Fructus Citri Sarcodactylis 16 parts, Strobilanthes sarcorrhizus Cling 24 parts, Semen sojae atricolor 21 parts, Herba Habenariae rhodochellae 12 parts, Radix et Rhizoma Gynurae divaricatae 24 parts, Rhizoma Chiritae Fimbrisepalae 14 parts, Balanophora dioica R Br ex Royle 28 parts, Radix Triostei Pinnatifidi 29 parts, Herba Setariae Viridis 16 parts, Herba Cirsii 17 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 28 parts, Radix Osbeckiae Crinitae 24 parts, Radix dioscoreae subcalvae 21 parts, Nodus Mori 9 parts, Herba Bulbophylli Odoratissim 30 parts and Flos Farfarae 22 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Coriandri 25 parts, Radix Stellariae Yunnanensis 18 parts, Fructus Citri Sarcodactylis 13 parts, Strobilanthes sarcorrhizus Cling 27 parts, Semen sojae atricolor 19 parts, Herba Habenariae rhodochellae 15 parts, Radix et Rhizoma Gynurae divaricatae 22 parts, Rhizoma Chiritae Fimbrisepalae 17 parts, Balanophora dioica R Br ex Royle 25 parts, Radix Triostei Pinnatifidi 32 parts, Herba Setariae Viridis 13 parts, Herba Cirsii 19 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 26 parts, Radix Osbeckiae Crinitae 26 parts, Radix dioscoreae subcalvae 20 parts, Nodus Mori 12 parts, Herba Bulbophylli Odoratissim 29 parts and Flos Farfarae 25 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae and Balanophora dioica R Br ex Royle mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: oral liquid

Get Herba Coriandri 250g, Radix Stellariae Yunnanensis 180g, Fructus Citri Sarcodactylis 130g, Strobilanthes sarcorrhizus Cling 270g, Semen sojae atricolor 190g, Herba Habenariae rhodochellae 150g, Radix et Rhizoma Gynurae divaricatae 220g, Rhizoma Chiritae Fimbrisepalae 170g, Balanophora dioica R Br ex Royle 250g, Radix Triostei Pinnatifidi 320g, Herba Setariae Viridis 130g, Herba Cirsii 190g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 260g, Radix Osbeckiae Crinitae 260g, Radix dioscoreae subcalvae 200g, Nodus Mori 120g, Herba Bulbophylli Odoratissim 290g and Flos Farfarae 250g;

Prepare according to the following steps:

The first step, by Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae and Balanophora dioica R Br ex Royle mixing, add relative to mixture 4 times amount determining alcohol be 65% alcohol reflux 3 times, each 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4 times of water gagings, boils 3 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;

3rd step, the described mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: .2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

Embodiment 2: capsule

Get Herba Coriandri 280g, Radix Stellariae Yunnanensis 160g, Fructus Citri Sarcodactylis 160g, Strobilanthes sarcorrhizus Cling 240g, Semen sojae atricolor 210g, Herba Habenariae rhodochellae 120g, Radix et Rhizoma Gynurae divaricatae 240g, Rhizoma Chiritae Fimbrisepalae 140g, Balanophora dioica R Br ex Royle 280g, Radix Triostei Pinnatifidi 290g, Herba Setariae Viridis 160g, Herba Cirsii 170g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 280g, Radix Osbeckiae Crinitae 240g, Radix dioscoreae subcalvae 210g, Nodus Mori 90g, Herba Bulbophylli Odoratissim 300g and Flos Farfarae 220g;

Prepare according to the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; Filter the ethanol that the medicinal residues obtained add the determining alcohol 95% relative to described medicinal residues quality 2 times again, reflux 3 hours, extract, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.4:0.3, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 2, (concentration is 7.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>36.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.103g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 705 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 2 capsule of the present invention presses 13.25,19.36 and 32.65g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 98 routine cases are the Sterility patient that year October in April, 2013 to 2014, my institute's department of obstetrics and gynecology were gone to a doctor, get rid of other reasons and cause infertile, women gets rid of systemic disease and reproductive malformation, tuberculosis, inflammation, tumor etc.; Month premenstrual or menstrual onset did endometrial biopsy or diagnostic curettage in 12 hours, got rid of endometrial tuberculosis.Equal detailed medical history-taking, complete physical examination, the general disease and the male that get rid of impact fertility are abnormal.98 people are divided into two groups at random, matched group 48 people, age 25-37 year; Fertility person 30 example, infertility 18 example; Course of disease > 2 years and < 3 years persons 23 example, >=3 years and < 4 years person 20 examples, more than 4 years and 4 years person 5 examples.Treatment group 50 people, age 26-36 year; Fertility person 31 example, infertility person 19 example; Course of disease > 2 years and < 3 years persons 24 example, >=3 years and < 4 years person 21 examples, 4 years and above person 5 example.Through statistics, two groups of patient baseline's data no significant difference (P > 0.05), have comparability.

Standards of Chinese Medical Syndrome Differentiation: with reference to " Chinese medical disease Standardization of diagnosis and curative effect " relevant criterion: the women of child-bearing age marry more than 1 year, matrimonial cohabitation, syngamy function is normal, and not practising contraception and fail the person of becoming pregnant, is fertility.Once there is motherhood history, and continued and more than 1 year, interval, do not practise contraception and not conceived person, be called infertility.

Damp-heat type: card is shown in that menstruation is successively irregularly, and many through the dim red amount of color, matter is stained with dirty taste, or leukorrhagia is red mixes mutually in vain, or muddiness is as water from washing rice, red tongue with yellowish and greasy fur, soft and rapid pulse.

Exclusion standard: (1) does not meet diagnostic criteria person; (2) reason such as women's systemic disease and reproductive malformation, tuberculosis, inflammation, tumor causes infertile person; (3) below 20 years old or more than 50 years old person; (4) general disease and the male that get rid of impact fertility are abnormal; (5) not by regulation medication, curative effect cannot be judged, or the not congruent judgement person that affects the treatment of data.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 2 capsule, each 4, every day 3 times.1 menstrual cycle was 1 course for the treatment of, took 6 courses for the treatment of continuously, and premenstrual 1 week starts to take, and clothes were to premenstrual 1 week of next time altogether, not drug withdrawal in menstrual period, and in drug administration process, pregnant person stops using.

Matched group: menstrual cycle the 5th day starts, every day oral citric acid clomiphene 50mgmg, estradiol valerate (progynova) 1mg/d, is used in conjunction 5 days.1 menstrual cycle was 1 course for the treatment of, took 6 courses for the treatment of continuously, and in drug administration process, pregnant person stops using.

Curative effect judging standard: curative effect determinate standard is with reference to evaluation infertile in " Chinese medical disease Standardization of diagnosis and curative effect ".Cure: treatment cycle is become pregnant, clinical disease disappears; Take a turn for the better: treatment cycle unpregnancy, clinical disease is clearly better (comprising symptom, sign and lab testing etc.); Invalid: treatment cycle unpregnancy, clinical disease does not disappear or increases the weight of.

Therapeutic outcome: two groups treat 6 months respectively after, statistical result is see table 1 and table 2.

A table 1 liang group treats two groups of comparitive study (example) after 6 months respectively:

	n	Cure	Take a turn for the better	Invalid	Effectively total
						Treatment group	50	33	15	2	48(96％)
Matched group	48	20	15	13	35(72.9％)

As can be seen from Table 1, adopt treatment by Chinese herbs damp-heat type of the present invention infertile, relative to matched group, on therapeutic effect, there is significant improvement.

Table 2 liang group is treated respectively after 6 months and is cured number and cure rate comparative example (%) stage by stage:

	Number of cases	Treat 1 ~ 2 month	Treat 2 ~ 4 months	Treat 4 ~ 6 months
					Treatment group	33	8(16％)	21(42％)	33(66％)
Matched group	20	3(6.25％)	11(22.92％)	20(41.67％)

As can be seen from Table 2, adopt treatment by Chinese herbs damp-heat type of the present invention infertile, significantly shorten on the course for the treatment of relative to matched group.

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Untoward reaction: the routine patient for the treatment of group 50 all has no adverse reaction after taking the embodiment of the present invention 2 capsule.Matched group 48 routine patient 3 example occurs that the stomach discomfort such as Nausea and vomiting, stomachache reacts, and the discomforts such as mammary swelling sense appear in 2 examples, and blurred vision appears in 1 example, and spirit depressing and insomnia appear in 1 example, and after drug withdrawal, above-mentioned symptom can fade away.

Concrete case: Zhang, women, 36 years old, once gave birth to a son, and educated and within latter 2 years half, do not practise contraception but unpregnancy always, be admitted to hospital and see a doctor, card is shown in menstruation successively irregularly, and many through the dim red amount of color, matter is stained with dirty taste, leukorrhagia is muddy as water from washing rice, and red tongue with yellowish and greasy fur, soft and rapid pulse, is diagnosed as damp-heat type secondary infertility.Give capsule of the present invention oral, each 4, every day 3 times, premenstrual 1 week starts to take, clothes extremely next premenstrual 1 week, not drug withdrawal in menstrual period.Treat after 4 months, patient is conceived.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the Chinese medicine that damp-heat type is infertile, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae, Balanophora dioica R Br ex Royle, Radix Triostei Pinnatifidi, Herba Setariae Viridis, Herba Cirsii, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu, Radix Osbeckiae Crinitae, Radix dioscoreae subcalvae, Nodus Mori, Herba Bulbophylli Odoratissim and Flos Farfarae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Coriandri 20 ~ 30 parts, Radix Stellariae Yunnanensis 10 ~ 20 parts, Fructus Citri Sarcodactylis 10 ~ 20 parts, Strobilanthes sarcorrhizus Cling 20 ~ 30 parts, Semen sojae atricolor 15 ~ 25 parts, Herba Habenariae rhodochellae 8 ~ 18 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 30 parts, Rhizoma Chiritae Fimbrisepalae 10 ~ 20 parts, Balanophora dioica R Br ex Royle 22 ~ 32 parts, Radix Triostei Pinnatifidi 25 ~ 35 parts, Herba Setariae Viridis 10 ~ 20 parts, Herba Cirsii 10 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 20 ~ 30 parts, Radix Osbeckiae Crinitae 20 ~ 30 parts, Radix dioscoreae subcalvae 15 ~ 25 parts, Nodus Mori 5 ~ 15 parts, Herba Bulbophylli Odoratissim 23 ~ 33 parts and Flos Farfarae 18 ~ 28 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Coriandri 25 ~ 30 parts, Radix Stellariae Yunnanensis 15 ~ 20 parts, Fructus Citri Sarcodactylis 12 ~ 17 parts, Strobilanthes sarcorrhizus Cling 23 ~ 28 parts, Semen sojae atricolor 17 ~ 22 parts, Herba Habenariae rhodochellae 11 ~ 16 parts, Radix et Rhizoma Gynurae divaricatae 20 ~ 25 parts, Rhizoma Chiritae Fimbrisepalae 13 ~ 18 parts, Balanophora dioica R Br ex Royle 24 ~ 29 parts, Radix Triostei Pinnatifidi 28 ~ 33 parts, Herba Setariae Viridis 12 ~ 17 parts, Herba Cirsii 15 ~ 20 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 25 ~ 30 parts, Radix Osbeckiae Crinitae 23 ~ 28 parts, Radix dioscoreae subcalvae 17 ~ 22 parts, Nodus Mori 8 ~ 13 parts, Herba Bulbophylli Odoratissim 26 ~ 31 parts and Flos Farfarae 21 ~ 26 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Coriandri 28 parts, Radix Stellariae Yunnanensis 16 parts, Fructus Citri Sarcodactylis 16 parts, Strobilanthes sarcorrhizus Cling 24 parts, Semen sojae atricolor 21 parts, Herba Habenariae rhodochellae 12 parts, Radix et Rhizoma Gynurae divaricatae 24 parts, Rhizoma Chiritae Fimbrisepalae 14 parts, Balanophora dioica R Br ex Royle 28 parts, Radix Triostei Pinnatifidi 29 parts, Herba Setariae Viridis 16 parts, Herba Cirsii 17 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 28 parts, Radix Osbeckiae Crinitae 24 parts, Radix dioscoreae subcalvae 21 parts, Nodus Mori 9 parts, Herba Bulbophylli Odoratissim 30 parts and Flos Farfarae 22 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Coriandri 25 parts, Radix Stellariae Yunnanensis 18 parts, Fructus Citri Sarcodactylis 13 parts, Strobilanthes sarcorrhizus Cling 27 parts, Semen sojae atricolor 19 parts, Herba Habenariae rhodochellae 15 parts, Radix et Rhizoma Gynurae divaricatae 22 parts, Rhizoma Chiritae Fimbrisepalae 17 parts, Balanophora dioica R Br ex Royle 25 parts, Radix Triostei Pinnatifidi 32 parts, Herba Setariae Viridis 13 parts, Herba Cirsii 19 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 26 parts, Radix Osbeckiae Crinitae 26 parts, Radix dioscoreae subcalvae 20 parts, Nodus Mori 12 parts, Herba Bulbophylli Odoratissim 29 parts and Flos Farfarae 25 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae and Balanophora dioica R Br ex Royle mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

8. the preparation method of Chinese medicine as described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is oral liquid, and its preparation method comprises the following steps:

The first step, by Herba Coriandri, Radix Stellariae Yunnanensis, Fructus Citri Sarcodactylis, Strobilanthes sarcorrhizus Cling, Semen sojae atricolor, Herba Habenariae rhodochellae, Radix et Rhizoma Gynurae divaricatae, Rhizoma Chiritae Fimbrisepalae and Balanophora dioica R Br ex Royle mixing, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours, and refrigerated storage temperature is 2 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described Chinese medicine preparation oral liquid finished product.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.