CN103356802A - Medicament for treating mastitis, and preparation method thereof - Google Patents

Medicament for treating mastitis, and preparation method thereof Download PDF

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CN103356802A
CN103356802A CN2013103174871A CN201310317487A CN103356802A CN 103356802 A CN103356802 A CN 103356802A CN 2013103174871 A CN2013103174871 A CN 2013103174871A CN 201310317487 A CN201310317487 A CN 201310317487A CN 103356802 A CN103356802 A CN 103356802A
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radix
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trichosanthis
clean
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CN103356802B (en
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张佳奇
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张佳奇
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Abstract

The invention discloses a medicament for treating mastitis, and a peparation method thereof. The medicament is prepared by dandelion, licorice, radix trichosanthis, fructus trichosanthis, honeysuckle flower, rorsythia suspense, Chinese angelica and radix paeoniae alba according to a certain weight ratio. The medicament has the functions of clearing heat, detoxifying, promoting the circulation of qi, expelling stagnation, activating blood circulation, dissipating binds, relieving swelling and stopping pain; and has the advantages of being fast in effectiveness, good in curative effect and high in cure rate when used to treat mastitis.

Description

A kind of medicine for the treatment of mastitis and preparation method thereof
Technical field
The present invention relates to a kind of medicine that is used for the treatment of mastitis and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Mastitis refer to that the acute festering type of mammary gland infects, and are the puerperal commonly encountered diseases, are one of reasons that causes puerperal fever, are most commonly in the nursing women, especially the primipara.Any time of age of sucking all can occur, and the beginning of suckling is the most common.Mastitis are the common a kind of diseases of primipara, and the lighter normally breast-feeds for the baby, and severe one is then wanted operative treatment.At present, western medicine mastitis poor effect, and more side effect is arranged, therefore, there is great demand in people to the Chinese medicine of effective treatment mastitis.
Summary of the invention
The inventor has finally found the medicine of effective treatment mastitis, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can effectively treat mastitis.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Taraxaci, Radix Glycyrrhizae, Radix Trichosanthis, Semen Trichosanthis, Flos Lonicerae, Fructus Forsythiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Chuanxiong, Nidus Vespae, Radix Rehmanniae medicine to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby recurrence that can the fast treating mastitis.Wherein select Herba Taraxaci to be because its property bitter but sweet flavor is cold, enter liver, stomach warp, heat-clearing and toxic substances removing is arranged, and the function of diuresis eliminating stagnation is controlled acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription is processed usefulness, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus , Jing Epilepsy; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Radix Trichosanthis to be because its nature and flavor sweetness and bitterness is sour, cold enters lung, stomach warp, has and promotes the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, and the function of detumescence is controlled calentura thirsty, quenches one's thirst jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.Select Semen Trichosanthis to be because its nature and flavor are sweet, cold, return lung, stomach, large intestine channel, moistening the lung and resolving phlegm is arranged, the function of laxation relieving constipation is controlled cough caused by dryness expectorant glutinous, the dryness of the intestine constipation.Select Flos Lonicerae to be because its nature and flavor are sweet, cold, enter lung, stomach warp, heat clearing away is arranged, the function of detoxifcation is controlled the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select Fructus Forsythiae to be because its nature and flavor are bitter, cold enters the heart, liver, gallbladder meridian, and heat clearing away is arranged, detoxifcation, eliminating stagnation, the function of detumescence, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Selecting the Radix Paeoniae Alba is that cold enters liver, spleen channel, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Radix Bupleuri to be because its nature and flavor are bitter, cold enters liver, gallbladder meridian, and reconciling superficies and interior is arranged, and is soothing the liver, and the function of yang invigorating is controlled alternate attack of chill and fever, fullness in the chest and hypochondriac pain, and bitter taste is deaf, headache and dizziness, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature enters liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Select Nidus Vespae to be because its nature and flavor are sweet, flat, return the stomach warp, dispel the wind, counteracting toxic substances, parasite killing, the function of pain relieving is used for toothache due to dental caries, sore swollen toxin, acute mastitis, scrofula, skin stubborn dermatitis, fungal infection of hand and foot.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Herba Taraxaci 10-20 gram Radix Glycyrrhizaes 10-20 gram Radix Trichosanthis 5-15 grams
Semen Trichosanthis 5-10 gram Flos Loniceraes 15-25 gram Fructus Forsythiaes 6-11 grams
Radix Angelicae Sinensis 15-25 gram Radix Paeoniae Albas 5-15 gram Radix Bupleuri 10-20 grams
Rhizoma Chuanxiong 5-10 gram Nidus Vespae 10-20 gram Radix Rehmanniae 5-15 grams
Preferable amount is
Herba Taraxaci 15 gram Radix Glycyrrhizaes 15 gram Radix Trichosanthis 10 grams
Semen Trichosanthis 8 gram Flos Loniceraes 20 gram Fructus Forsythiaes 9 grams
The Radix Angelicae Sinensis 20 gram Radix Paeoniae Albas 10 gram Radix Bupleuri 15 grams
Rhizoma Chuanxiong 8 gram Nidus Vespae 15 gram Radix Rehmanniae 10 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Herba Taraxaci: choose decontamination, clean earth, cutting is dried;
2, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;
3, Radix Trichosanthis: choose decontamination, size block separately, and is saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section is dried, or washed, and pulls out, shines extremely driedly, smashes into fritter;
4, Semen Trichosanthis: get crude drug, remove shrivelled seed, impurity, the time spent smashs to pieces;
5, Flos Lonicerae: sieve removes silt, chooses clean impurity;
6, Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;
7, Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
8, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
9, Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
10, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
11, Nidus Vespae: get crude drug, remove impurity, stripping and slicing, sieve removes chip;
12, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit is cut sheet, drying, and sieve removes chip.
Two, preparation
1, Herba Taraxaci, Radix Glycyrrhizae, Radix Trichosanthis, Semen Trichosanthis, Flos Lonicerae, Fructus Forsythiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Chuanxiong, Nidus Vespae, the Radix Rehmanniae medicine with described weight decocts with water secondary, add for the first time 6 times of amounts of water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, and filtered to get decoction liquor for the first time.
2, the medicinal residues that filter are added 4 times of amounts of water, intense fire boils, and uses slow fire boiling 15 minutes again, gets for the second time decoction liquor.
3, twice decoction liquor medicinal liquid merged, intense fire boils, and uses slow fire boiling 10 minutes again, medicinal liquid is divided into 3 doses takes.
Medicine of the present invention has heat-clearing and toxic substances removing, activating QI to alleviate the depression, and promoting blood circulation and stopping pain, eliminating stagnation, the function of detumescence is used for the treatment of mastitis, short treating period, instant effect, has no side effect.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day 2 times, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy mastitis of the present invention
1, physical data
Accept mastitis patient totally 200 examples for medical treatment.
2, diagnostic criteria
Initial phase: from the beginning of often there being nipple to break, sensory papillae twinge during suckling, smooth or caking can have one or two latex dust blocking barriers sometimes with human milk silt.Then breast local swelling pain is lumpd with little or no, and with tenderness, color of the leather is not red or little red, the not hot or slight fever of skin.General Symptoms is not obvious, or with fever with aversion to cold, headache uncomfortable in chest, irritated liable to fits of temper, inappetence. 
Become the pus stage: trouble swelling of the breast piece does not disappear or increases gradually, and local pain increases the weight of, or throbbing pain is arranged, and very persistence has an intense pain, with obvious tenderness, color of the leather is red, and skin is scorching hot, and has high fever not move back, thirsty think of drink, the anorexia of feeling sick, homonymy axillary gland enlargement tenderness.To breast red and swollen heat pain about the 10th day, the gradually deliquescing of lump in breast central authorities has fluctuation by it, local red and swollen heating, and tenderness is obvious, and puncture suction has pus, and pus can flow out from newborn key sometimes, the General Symptoms aggravation. 
Routed after-stage: when acute abscess was ripe, ulceration came to a head voluntarily, or the surgical incision evacuation of pus.If pus goes out unobstructed, then the local swollen alleviation of pain that disappears generates heat, the transference cure of being afraid of cold, and the open sore part heals gradually.If it is not smooth that routed rear pus goes out, swollen gesture does not disappear, and pain does not subtract, and fever of the body does not move back, and may form a bag pus, or pus involves other newborn networks formation biography capsule acute mastitis.Also have the rear milk of bursting to overflow from the open sore part, obstinate forms mammary fistula.
3, Therapeutic Method
Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 15 days is a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: the mastitis symptom disappears, and observes half a year without the recidivist;
Take a turn for the better: the mastitis symptom is obviously improved, and body constitution progressively strengthens;
Invalid: the mastitis symptom does not reach improvement standard person without change.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy mastitis patient 200 examples of the present invention, produce effects 192 examples as a result, obvious effective rate is 96%, 5 examples that take a turn for the better, improvement rate is 2.5%, invalid 3 examples, total effective rate is 98.5%.

Claims (3)

1. medicine for the treatment of mastitis, it is characterized in that: it is to be made by the crude drug in the following weight range:
Herba Taraxaci 10-20 gram Radix Glycyrrhizaes 10-20 gram Radix Trichosanthis 5-15 grams
Semen Trichosanthis 5-10 gram Flos Loniceraes 15-25 gram Fructus Forsythiaes 6-11 grams
Radix Angelicae Sinensis 15-25 gram Radix Paeoniae Albas 5-15 gram Radix Bupleuri 10-20 grams
Rhizoma Chuanxiong 5-10 gram Nidus Vespae 10-20 gram Radix Rehmanniae 5-15 grams.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Herba Taraxaci 15 gram Radix Glycyrrhizaes 15 gram Radix Trichosanthis 10 grams
Semen Trichosanthis 8 gram Flos Loniceraes 20 gram Fructus Forsythiaes 9 grams
The Radix Angelicae Sinensis 20 gram Radix Paeoniae Albas 10 gram Radix Bupleuri 15 grams
Rhizoma Chuanxiong 8 gram Nidus Vespae 15 gram Radix Rehmanniae 10 grams.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) gets the raw materials ready
(1) Herba Taraxaci: choose decontamination, clean earth, cutting is dried;
(2) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, airing;
(3) Radix Trichosanthis: choose decontamination, size block separately, and is saturating with blister to sixty percent, pulls out, and moistening is even to inside and outside humidity, and section is dried, or washed, and pulls out, shines extremely driedly, smashes into fritter;
(4) Semen Trichosanthis: get crude drug, remove shrivelled seed, impurity, the time spent smashs to pieces;
(5) Flos Lonicerae: sieve removes silt, chooses clean impurity;
(6) Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;
(7) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(8) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(9) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through rear timely section, dry immediately;
(10) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;
(11) Nidus Vespae: get crude drug, remove impurity, stripping and slicing, sieve removes chip;
(12) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit is cut sheet, drying, and sieve removes chip;
(2) preparation
(1) Herba Taraxaci, Radix Glycyrrhizae, Radix Trichosanthis, Semen Trichosanthis, Flos Lonicerae, Fructus Forsythiae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Chuanxiong, Nidus Vespae, the Radix Rehmanniae medicine with described weight decocts with water secondary, add for the first time 6 times of amounts of water, soak after 120 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 30 minutes, and filtered to get decoction liquor for the first time;
(2) medicinal residues that filter are added 4 times of amounts of water, intense fire boils, and uses slow fire boiling 15 minutes again, gets for the second time decoction liquor;
(3) twice decoction liquor medicinal liquid merged, intense fire boils, and uses slow fire boiling 10 minutes again, medicinal liquid is divided into 3 doses takes.
CN201310317487.1A 2013-07-26 2013-07-26 Medicament for treating mastitis, and preparation method thereof Expired - Fee Related CN103356802B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104524168A (en) * 2014-12-21 2015-04-22 李洋 Medicine for treating acute mastitis
CN104784300A (en) * 2015-03-27 2015-07-22 李博 Traditional Chinese medicinal formula for preventing and treating postpartum mastitis of dairy cow
CN106620519A (en) * 2016-12-08 2017-05-10 冉兆斌 Drug for treating mammitis and preparation method thereof

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CN101623413A (en) * 2008-07-08 2010-01-13 张成赟 Chinese medicinal composition for treating women mastitis
CN101972444A (en) * 2010-07-13 2011-02-16 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine composition for treating mastitis and preparation method thereof
CN102198215A (en) * 2011-04-25 2011-09-28 赵亮 Traditional Chinese medicine used for treating mammitis

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CN101023992A (en) * 2007-03-26 2007-08-29 河南仲景药业股份有限公司 Medicine for treating mammary gland hyperplasia
CN101623413A (en) * 2008-07-08 2010-01-13 张成赟 Chinese medicinal composition for treating women mastitis
CN101972444A (en) * 2010-07-13 2011-02-16 泰一和浦(北京)中医药研究院有限公司 Traditional Chinese medicine composition for treating mastitis and preparation method thereof
CN102198215A (en) * 2011-04-25 2011-09-28 赵亮 Traditional Chinese medicine used for treating mammitis

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104524168A (en) * 2014-12-21 2015-04-22 李洋 Medicine for treating acute mastitis
CN104784300A (en) * 2015-03-27 2015-07-22 李博 Traditional Chinese medicinal formula for preventing and treating postpartum mastitis of dairy cow
CN106620519A (en) * 2016-12-08 2017-05-10 冉兆斌 Drug for treating mammitis and preparation method thereof

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