CN104840704A - Traditional Chinese medicine for treating indigestion gastricism type postpartum food damage and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating indigestion gastricism type postpartum food damage and a preparation method thereof. The traditional Chinese medicine comprises the following raw medicinal materials: cynanchum glaucescens, pericarpium arecae, twisted-stalk, medicated leaven, blueflower cicerbita root, franxinus pistacifolia feng, angled bittersweet root, champac michelia root, tanarius major, endive, narrowbract Indian kalimeris herb, himalayan eriosema root, eupatorium, coffee senna fruit seeds, himalayan creeper herb, humulus lupulus, burmann cinnamon bark and coriander. The traditional Chinese medicine provided by the invention has the advantages of definite curative effect on indigestion gastricism type postpartum food damage and low toxic and side effects.

Description

A kind of food stagnation hinders Chinese medicine of gastric pattern puerperal dyspepsia and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of food stagnation and hindering Chinese medicine of gastric pattern puerperal dyspepsia and preparation method thereof.

Background technology

Puerperal dyspepsia refers to that puerperal, all functions were not answered, and taste are originally weak, if eating and drinking without temperance, and surfeit delicious food, impairing the spleen and stomach, then failing of the spleen to transport.Puerperal, spleen and stomach function did not recover, and as intemperance of taking food, depressed emotion, or have taste chronic disease, puerperal, temper was more empty, then food stagnation is in stomach, transporting mistake department and cause primary disease.

Tcm treatment according to syndrome differentiation, is generally divided into following three types:

Food stagnation hinders gastric pattern: puerperal, gastral cavilty distension, more so, eructating foul odor pantothenic acid, defecated dirty smelly in feed because of eating and drinking without temperance.Thick and greasy fur, stringy pulse or cunning.

Stagnation of liver-QI is got ill from overeating type: then flatulence of taking food puerperal, feeling of fullness and disecomfort in the chest and hypochondrium, belch acid regurgitation, depressed emotion, lochia is not smooth.Yellow and greasy fur, stringy pulse.

Insufficiency of the spleen type of getting ill from overeating: have taste chronic disease, gastral cavilty feeling of fullness, anorexia, spiritlessness and weakness, loose stool, shallow complexion.Thin fur, thready and weak pulse.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of food stagnation to hinder Chinese medicine of gastric pattern puerperal dyspepsia and preparation method thereof, and Chinese medicine of the present invention hinders gastric pattern puerperal dyspepsia to have definite curative effect to food stagnation, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides the Chinese medicine that a kind of food stagnation hinders gastric pattern puerperal dyspepsia, its raw medicinal material comprises: Rhizoma Cynanchi Stauntonii, Pericarpium Arecae, Streptopus simplex D. Don, Massa Medicata Fermentata, Cicerbita cyanea (D. Don) beauverd, great Pi disappears, and hangs fruit, Radix micheliae champacae, Lignum Dalbergiae Odoriferae, Herba Cichorii, Pathways Grass, Eriosema himalaicum Ohashi, Herba Eupatorii, Semen Cassiae Occidemtalis, Herba Parthenocissi Himalayanae, lobus cardiacus hops, Cortex Cinnamomi Burmannii and coriander.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be: Rhizoma Cynanchi Stauntonii 10-30 part, Pericarpium Arecae 10-30 part, Streptopus simplex D. Don 10-30 part, Massa Medicata Fermentata 5-15 part, Cicerbita cyanea (D. Don) beauverd 10-30 part, great Pi disappears 10-20 part, hangs fruit 10-20 part, Radix micheliae champacae 15-25 part, Lignum Dalbergiae Odoriferae 20-35 part, Herba Cichorii 20-40 part, Pathways Grass 15-30 part, Eriosema himalaicum Ohashi 25-40 part, Herba Eupatorii 10-30 part, Semen Cassiae Occidemtalis 5-25 part, Herba Parthenocissi Himalayanae 20-40 part, lobus cardiacus hops 20-40 part, Cortex Cinnamomi Burmannii 10-30 part and coriander 15-30 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be: Rhizoma Cynanchi Stauntonii 15-25 part, Pericarpium Arecae 15-25 part, Streptopus simplex D. Don 12-25 part, Massa Medicata Fermentata 5-10 part, Cicerbita cyanea (D. Don) beauverd 15-25 part, great Pi disappears 12-18 part, hangs fruit 12-18 part, Radix micheliae champacae 18-23 part, Lignum Dalbergiae Odoriferae 22-32 part, Herba Cichorii 25-35 part, Pathways Grass 18-25 part, Eriosema himalaicum Ohashi 28-35 part, Herba Eupatorii 18-23 part, Semen Cassiae Occidemtalis 12-18 part, Herba Parthenocissi Himalayanae 25-35 part, lobus cardiacus hops 25-35 part, Cortex Cinnamomi Burmannii 12-25 part and coriander 18-25 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be again: Rhizoma Cynanchi Stauntonii 18 parts, Pericarpium Arecae 23 parts, Streptopus simplex D. Don 20 parts, Massa Medicata Fermentata 8 parts, Cicerbita cyanea (D. Don) beauverd 20 parts, great Pi disappears 16 parts, hangs fruit 16 parts, Radix micheliae champacae 18 parts, Lignum Dalbergiae Odoriferae 28 parts, Herba Cichorii 28 parts, Pathways Grass 20 parts, Eriosema himalaicum Ohashi 30 parts, Herba Eupatorii 19 parts, Semen Cassiae Occidemtalis 17 parts, Herba Parthenocissi Himalayanae 28 parts, lobus cardiacus hops 34 parts, Cortex Cinnamomi Burmannii 20 parts and coriander 19 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be: Rhizoma Cynanchi Stauntonii 22 parts, Pericarpium Arecae 20 parts, Streptopus simplex D. Don 22 parts, Massa Medicata Fermentata 7 parts, Cicerbita cyanea (D. Don) beauverd 15 parts, great Pi disappears 14 parts, hangs fruit 13 parts, Radix micheliae champacae 21 parts, Lignum Dalbergiae Odoriferae 26 parts, Herba Cichorii 33 parts, Pathways Grass 23 parts, Eriosema himalaicum Ohashi 28 parts, Herba Eupatorii 21 parts, Semen Cassiae Occidemtalis 14 parts, Herba Parthenocissi Himalayanae 32 parts, lobus cardiacus hops 27 parts, Cortex Cinnamomi Burmannii 22 parts and coriander 23 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, leave standstill 30 ~ 50 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Beneficial effect of the present invention: Chinese medicine of the present invention hinders gastric pattern puerperal dyspepsia to have definite curative effect to food stagnation, and toxic and side effects is little.

Detailed description of the invention

The invention provides the Chinese medicine that a kind of food stagnation hinders gastric pattern puerperal dyspepsia, its raw medicinal material comprises: Rhizoma Cynanchi Stauntonii, Pericarpium Arecae, Streptopus simplex D. Don, Massa Medicata Fermentata, Cicerbita cyanea (D. Don) beauverd, great Pi disappears, and hangs fruit, Radix micheliae champacae, Lignum Dalbergiae Odoriferae, Herba Cichorii, Pathways Grass, Eriosema himalaicum Ohashi, Herba Eupatorii, Semen Cassiae Occidemtalis, Herba Parthenocissi Himalayanae, lobus cardiacus hops, Cortex Cinnamomi Burmannii and coriander.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Rhizoma Cynanchi Stauntonii: [another name] goose pipe Rhizoma Cynanchi Stauntonii, Folium Bambusae Rhizoma Cynanchi Stauntonii.[source] this product is dry rhizome and the root of asclepiadaceae plant rhizoma et radix cynanchi stauntoni or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii.Autumn excavates, and cleans, dries.[nature and flavor] are pungent, bitter, tepor.[return through] returns lung meridian.[function cures mainly] sending down the abnormal ascending QI, expectorant, cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.

Pericarpium Arecae: [another name] pericarpium arecae, PERICARPIUM ARECAE PERICARPIUM ARECAE, Fu hair, Semen Arecae clothing, large abdomen floss.[source] medical material Ji Yuan: be the peel of babassu Semen Arecae.Gather and store: winter, mature fruit of gathering in season in spring two, peel peel, beat pine, soak, dry in second water, then beating pine removing outer peel.[nature and flavor] acrid in the mouth; Slightly warm in nature.[return through] spleen; Stomach; Large intestine; Small intestine meridian.[function cures mainly] therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO; Line water detumescence.Main breast abdominal distention is vexed; Edema; Foot gas; Dysuria.[extracts] " China's book on Chinese herbal medicine "

Streptopus simplex D. Don: [another name] Radix Streptopi Simplicis, female's short, bristly hair or beard, Streptopus simplex.[source] Liliaceae Streptopus simplex D. Don, is used as medicine with root.[nature and flavor] are sweet, light, cold.[function cures mainly] clearing away lung-heat to relieve cough, invigorating the spleen and regulating the stomach.Cure mainly cough due to lung-heat, incoordination between the spleen and stomach, have palpitation, breathe hard, bones and muscles pain.[extracts] " national Chinese herbal medicine compilation "

Massa Medicata Fermentata: [another name] Massa Medicata Fermentata (" book on Chinese herbal medicine is just read ").The medicines such as [source] is Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed after, through the herbal leaven of fermentation.[nature and flavor] sweet, acrid, warm.[return through] enters spleen, stomach warp.[function cures mainly] invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending." book on Chinese herbal medicine is stated ": " cure the wound summer-heat, and being affected by fluid-retention is eaten, and hinders overstrain, and malaria flatulence due to stagnation of QI is demonstrate,proved, and edema distension gathers, cough due to fluid-retention, and vomiting regurgitation, cholera, blood-retention, pained, gastric abscess, hypochondriac pain, numbness flaccidity is dizzy, heavy sensation of the body, can not eat, jaundice." [extracts] " Chinese medicine voluminous dictionary "

Cicerbita cyanea (D. Don) beauverd: [another name] Radix Sophorae Flavescentis (" Yunnan Chinese herbal medicine ").[source] is the root of feverfew Cicerbita cyanea (D. Don) beauverd.Autumn and winter gather, and section, dries.[nature and flavor] are " Guizhou medical herbs " 1.: " pungent micro-hardship, flat." [function cures mainly] heat clearing and inflammation relieving, invigorating the spleen and regulating the stomach, upper pain.Treat for stomachache, gastroenteritis.Bacillary dysentery, food stagnation is glutted, edema, eczema." Guizhou medical herbs ": " help digestion long-pending glutted." [extracts] " Chinese medicine voluminous dictionary "

Great Pi disappears: [another name] steps on that Pi Shu, beaver are old, cow's tail tree.[source] sweet-scented osmanthus University of Science and Technology skin disappears, and is used as medicine with bark.[nature and flavor] micro-hardship, flat.[function cures mainly] invigorating the stomach and promoting digestion, circulation of qi promoting treating blood disorders.Cure mainly food stagnation stomachache, chronic gastritis, qi-stagnating amenorrhea, migraine.Red River is regional with controlling tertian malaria, subtertian malaria; Root is used for driving pinworm.[extracts] " national Chinese herbal medicine compilation "

Hang fruit: [another name] Fructus Zanthoxyli Plansipini, Yunnan Fructus Schisandrae Chinensis.[source] Magnoliaceae hangs fruit, is used as medicine with fruit, root, stem.[nature and flavor] really: sour, sweet, temperature.Root, stem: pungent, temperature.[function cures mainly] really: the kidney invigorating of astringing the lung, arresting seminal emission hidroschesis.Cure mainly cough, inappetence, spontaneous perspiration, night sweat, neurasthenia, lumbago due to renal deficiency.Root, stem: relaxing muscles and tendons to promote blood circulation, pain relieving granulation promoting.Cure mainly rheumatic ostalgia, osteopatia sprain.[extracts] " national Chinese herbal medicine compilation "

Radix micheliae champacae: [another name] Radix Et Rhizoma Rhei osmanthus, sell secondary breathe out [Dai Nationality], Michelia champaca, Zhan foretells.The yellow blue Michelia champacaL. of [source] Magnoliaceae Michelia plant, with root and fruit medicine.Root can be adopted the whole year, and section is dried; The fruit autumn in summer gathers, and levigation is dried in peeling.[nature and flavor] are bitter, cool.[function cures mainly] root: wind-damp dispelling, throat.For rheumatic ostalgia, bony spur stalk larynx.Really: benefiting stomach and stopping pain.For dyspepsia, stomachache.[extracts] " national Chinese herbal medicine compilation "

Lignum Dalbergiae Odoriferae: [another name] mountain Fructus Citri tangerinae, Acronychi apedunculata (L.) Miq..[source] Rutaceae Acronychi apedunculata (L.) Miq. platymiscium Lignum Dalbergiae Odoriferae, is used as medicine with root, heartwood, leaf, fruit.The fruit autumn and winter adopt, and remainder is adopted the whole year, and section is dried or dries in the shade.[nature and flavor] are sweet, flat.[function cures mainly] root, dry wood, leaf: expelling wind and activating blood circulation, regulating QI to relieve pain.For rheumatic lumbago and scelalgia, treating swelling and pain by traumatic injury, bronchitis, stomachache, colicky.Fruit: invigorating the stomach and promoting digestion.For inappetence, dyspepsia.[extracts] " national Chinese herbal medicine compilation "

Herba Cichorii: [source] this strain Uygur nationality conventional crude drugs.For the aerial parts of feverfew saussurea intybus and Herba Cichorii.Autumn taps, and removing impurity, dries.[nature and flavor] micro-hardship, salty, cool.[function cures mainly] liver heat removing function of gallbladder promoting, invigorating the stomach and promoting digestion, inducing diuresis to remove edema.For jaundice due to damp-heat, stomachache lack of appetite, edema oliguria.[extracts] " Chinese Pharmacopoeia "

Pathways Grass: [another name] star Artemisia, floral leaf Herba Kalimeridis, Aster indicus.[source] is the herb of feverfew narrow leaf Aster indicus.Summer, autumn gather, and dry in the shade or using fresh herb.[source] is the herb of feverfew narrow leaf Aster indicus.Summer, autumn gather, and dry in the shade or using fresh herb.[function cures mainly] promoting digestion and invigorating the stomach, blood stasis dispelling detoxifies, and controls infantile malnutrition, diarrhoea, dysentery, venom, traumatic hemorrhage.[extracts] " Chinese medicine voluminous dictionary "

Eriosema himalaicum Ohashi: the short top top of [another name] Cor Gigeriae Galli, napiform root hair hemp nettle.[source] pulse family hair hemp nettle platymiscium Eriosema himalaicum Ohashi, is used as medicine with tuber.Autumn adopts, and cleans section, dries.[nature and flavor] are sweet, bitter, puckery, flat.[function cures mainly] stomach invigorating removing food stagnancy, regulating QI to relieve pain.For infantile malnutrition, dyspepsia, stomach abdomen pain, diarrhoea, traumatic injury.[extracts] " national Chinese herbal medicine compilation "

Herba Eupatorii: [another name] Herba Chlorophyti, Herba Lycopi, circle stalk Herba Lycopi, Ocimum basilicum L. var. pilosum.[source] this product is the dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Summer, Qiu Erji tap at twice, and removing impurity, dries.[nature and flavor] are pungent, flat.[return through] returns spleen, stomach, lung meridian.[function cures mainly] removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.[extracts] " Chinese Pharmacopoeia "

Semen Cassiae Occidemtalis: [another name] Semen sophorae (herbal for Relief of Famines), the sub-bean of pheasant (" Fujian traditional herbal medicine "), gold silver coin, golden angle youngster (" medicine will is planted in Jiangsu "), south of the River bean (" illustrated handbook planted by middle traditional Chinese medicines "), water pawl bean (" register planted by Guangxi medicine "), wind and cold bean, yellow Semen vignae sinensis (" Jiangsu medical material will ").The pod that [source] is leguminous plant Herba cassiae occidentalis or seed.Autumn, fruit became during heat to gather, and cut pod, dried.[nature and flavor] sweetness and bitterness, cool, poisonous.[function cures mainly] liver heat removing and eyesight improving, stomach invigorating, relieving constipation, removing toxic substances.Control conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, dyspepsia, stomachache, stomachache, dysentery, constipation." Jiangxi Chinese medicine ": " treat for stomachache, dyspepsia." [extracts] " Chinese medicine voluminous dictionary "

Herba Parthenocissi Himalayanae: [another name] Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae).[source] Rubiaceae Herba Parthenocissi Himalayanae, is used as medicine with root stock.[nature and flavor] are sweet, temperature.[function cures mainly] stomach invigorating.Cure mainly infantile malnutrition.[extracts] " national Chinese herbal medicine compilation "

Lobus cardiacus hops: [another name] Flos lupuli (Flos Humuli Lupuli), lobus cardiacus Fols lupuli.[source] Moraceae lobus cardiacus hops, is used as medicine with flower.[nature and flavor] are bitter, flat.[function cures mainly] invigorating the stomach and promoting digestion, calm diuresis, tuberculosis.Cure mainly loss of appetite, dyspepsia, hysteria, insomnia, chronic tuberculosis, the diseases such as cystitis.[extracts] " national Chinese herbal medicine compilation "

Cortex Cinnamomi Burmannii: [another name] Guangdong Cortex cinnamomi japonici (Ramulus Cinnamomi) (" Chinese tree taxonomy ").[source] is the cloudy fragrant bark of canella.[nature and flavor] 1. " south of the Five Ridges gather medicinal herbs record ": " acrid in the mouth." [function cures mainly] warming middle-JIAO, cold expelling, wind-damp dispelling.Control lack of appetite, abdominal distention, watery diarrhea, epigastric pain, rheumatism, skin ulcer swells, osteopatia sprain.[extracts] " Chinese medicine voluminous dictionary "

Coriander: [another name] Herba Coriandri, Herba Coriandri, coriander, prolong Sui.[source] this product is Umbelliferae coriander platymiscium coriander Coriandrum sativum L., is used as medicine with herb and mellow fruit.Herb spring and summer can be adopted, and cutting is dried.Fruit picking in summer is real, and decontamination, dries.[nature and flavor] are pungent, temperature.[return through] enters lung, stomach warp.[function cures mainly] delivers rash, stomach invigorating.Herb: measles without adequate eruption, catches a cold lossless; Really: dyspepsia, inappetence.[extracts] " national Chinese herbal medicine compilation "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Rhizoma Cynanchi Stauntonii 10-30 part, Pericarpium Arecae 10-30 part, Streptopus simplex D. Don 10-30 part, Massa Medicata Fermentata 5-15 part, Cicerbita cyanea (D. Don) beauverd 10-30 part, great Pi disappears 10-20 part, hang fruit 10-20 part, Radix micheliae champacae 15-25 part, Lignum Dalbergiae Odoriferae 20-35 part, Herba Cichorii 20-40 part, Pathways Grass 15-30 part, Eriosema himalaicum Ohashi 25-40 part, Herba Eupatorii 10-30 part, Semen Cassiae Occidemtalis 5-25 part, Herba Parthenocissi Himalayanae 20-40 part, lobus cardiacus hops 20-40 part, Cortex Cinnamomi Burmannii 10-30 part and coriander 15-30 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be: Rhizoma Cynanchi Stauntonii 15-25 part, Pericarpium Arecae 15-25 part, Streptopus simplex D. Don 12-25 part, Massa Medicata Fermentata 5-10 part, Cicerbita cyanea (D. Don) beauverd 15-25 part, great Pi disappears 12-18 part, hangs fruit 12-18 part, Radix micheliae champacae 18-23 part, Lignum Dalbergiae Odoriferae 22-32 part, Herba Cichorii 25-35 part, Pathways Grass 18-25 part, Eriosema himalaicum Ohashi 28-35 part, Herba Eupatorii 18-23 part, Semen Cassiae Occidemtalis 12-18 part, Herba Parthenocissi Himalayanae 25-35 part, lobus cardiacus hops 25-35 part, Cortex Cinnamomi Burmannii 12-25 part and coriander 18-25 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Cynanchi Stauntonii 18 parts, Pericarpium Arecae 23 parts, Streptopus simplex D. Don 20 parts, Massa Medicata Fermentata 8 parts, Cicerbita cyanea (D. Don) beauverd 20 parts, great Pi disappears 16 parts, hang fruit 16 parts, Radix micheliae champacae 18 parts, Lignum Dalbergiae Odoriferae 28 parts, Herba Cichorii 28 parts, Pathways Grass 20 parts, Eriosema himalaicum Ohashi 30 parts, Herba Eupatorii 19 parts, Semen Cassiae Occidemtalis 17 parts, Herba Parthenocissi Himalayanae 28 parts, lobus cardiacus hops 34 parts, Cortex Cinnamomi Burmannii 20 parts and coriander 19 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Rhizoma Cynanchi Stauntonii 22 parts, Pericarpium Arecae 20 parts, Streptopus simplex D. Don 22 parts, Massa Medicata Fermentata 7 parts, Cicerbita cyanea (D. Don) beauverd 15 parts, great Pi disappears 14 parts, hang fruit 13 parts, Radix micheliae champacae 21 parts, Lignum Dalbergiae Odoriferae 26 parts, Herba Cichorii 33 parts, Pathways Grass 23 parts, Eriosema himalaicum Ohashi 28 parts, Herba Eupatorii 21 parts, Semen Cassiae Occidemtalis 14 parts, Herba Parthenocissi Himalayanae 32 parts, lobus cardiacus hops 27 parts, Cortex Cinnamomi Burmannii 22 parts and coriander 23 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, leave standstill 30 ~ 50 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: tablet

Get Rhizoma Cynanchi Stauntonii 180g, Pericarpium Arecae 230g, Streptopus simplex D. Don 200g, Massa Medicata Fermentata 80g, Cicerbita cyanea (D. Don) beauverd 200g, great Pi disappear 160g, hang fruit 160g, Radix micheliae champacae 180g, Lignum Dalbergiae Odoriferae 280g, Herba Cichorii 280g, Pathways Grass 200g, Eriosema himalaicum Ohashi 300g, Herba Eupatorii 190g, Semen Cassiae Occidemtalis 170g, Herba Parthenocissi Himalayanae 280g, lobus cardiacus hops 340g, Cortex Cinnamomi Burmannii 200g and coriander 190g.

Prepare according to the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.035 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2: granule

Get Rhizoma Cynanchi Stauntonii 220g, Pericarpium Arecae 200g, Streptopus simplex D. Don 220g, Massa Medicata Fermentata 70g, Cicerbita cyanea (D. Don) beauverd 150g, great Pi disappear 140g, hang fruit 130g, Radix micheliae champacae 210g, Lignum Dalbergiae Odoriferae 260g, Herba Cichorii 330g, Pathways Grass 230g, Eriosema himalaicum Ohashi 280g, Herba Eupatorii 210g, Semen Cassiae Occidemtalis 140g, Herba Parthenocissi Himalayanae 320g, lobus cardiacus hops 270g, Cortex Cinnamomi Burmannii 220g and coriander 230g.

Prepare according to the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 95%, leave standstill 45 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.09Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 175 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.4 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 23 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 7.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>36.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 26g) oral administration gavage Chinese medicine of the present invention is 680 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 13.35,19.26 and 38.33g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: this group 90 example is the childbirth puerpera in my institute in April, 2013 ~ 2014 year July.At 26 ~ 42 years old age, be divided into treatment group and matched group at random.Treatment group 45 people, 26 ~ 40 years old age; Contrast Soviet Union 45 people, 27 ~ 42 years old age; Two groups of ages, the course of disease, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).

Diagnostic criteria:

, there is flatulence, abdominal distention or dyspepsia in Western medicine diagnose standard: inappetence appears in puerperal, can with rotten odor belch after feed, pantothenic acid, feels sick, the diseases such as vomiting, and patient does not suffer from intestinal obstruction that digestive tract ulcer and cesarean postoperate cause or intestinal adhesion etc.

Syndrome Types of TCM diagnostic criteria: food stagnation hinders gastric pattern: puerperal, gastral cavilty distension, more so, eructating foul odor pantothenic acid, defecated dirty smelly in feed because of eating and drinking without temperance.Thick and greasy fur, stringy pulse or cunning.

Treatment group: take the embodiment of the present invention 1 tablet every day 3 times, each 4,1 week 1 course for the treatment of; Be used in conjunction two courses for the treatment of.

Matched group: take lenitive pill (Tongrentang) every day 2 times, each 6g, 1 week 1 course for the treatment of; Be used in conjunction two courses for the treatment of.

Curative effect judging standard: cure: the symptoms such as anorexia flatulence all disappear, and the mental status is good; Effective: the symptoms such as anorexia flatulence are clearly better, and the mental status is obviously improved; Invalid: still anorexia, the mental status is poor.

Therapeutic outcome: two groups treat 1 course for the treatment of respectively after, statistical result is see table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs food stagnation of the present invention to hinder gastric pattern puerperal dyspepsia, relative to matched group on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs food stagnation of the present invention to hinder gastric pattern puerperal dyspepsia, relative to Chinese patent medicine, treatment the course for the treatment of on significantly shorten.

After table 1 liang group treats 2 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	n	Cure	Effectively	Invalid	Effectively total
						Treatment group	45	39	6	0	45(100％)
Matched group	45	28	12	5	40(88.9％)

Number and time comparative example (%) is cured after a table 2 liang group treats 2 courses for the treatment of respectively

Group	Number of cases	Medication 5 days	Medication 10 days	Medication 14 days
					Treatment group	39	13(28.9％)	30(66.7％)	39(86.7％)
Matched group	28	7(15.6％)	20(44.4％)	28(62.2％)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, the advantage that has no side effect; Follow up a case by regular visits to 2 months respectively to the 28 routine patients that 39 routine patients and the matched group for the treatment of group healing are cured, result is added up, and the routine patient for the treatment of group 39 is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 28, recurs 3 people, relapse rate 10.7%.

Concrete case: money, women, 27 years old, occurs that flatulence and pantothenic acid are gone to a doctor puerperal, and puerperal, gastral cavilty distension, more so, eructating foul odor pantothenic acid, defecated dirty smelly, thick and greasy fur, rolling pulse in feed because of eating and drinking without temperance.Be diagnosed as food stagnation and hinder gastric pattern puerperal dyspepsia.Take Chinese medicine embodiment of the present invention 1 every day 3 times, each 4, treat after 11 days, recovery from illness, follows up a case by regular visits to and does not recur for 2 months.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the Chinese medicine that food stagnation hinders gastric pattern puerperal dyspepsia, it is characterized in that, comprise following raw medicinal material: Rhizoma Cynanchi Stauntonii, Pericarpium Arecae, Streptopus simplex D. Don, Massa Medicata Fermentata, Cicerbita cyanea (D. Don) beauverd, great Pi disappears, and hangs fruit, Radix micheliae champacae, Lignum Dalbergiae Odoriferae, Herba Cichorii, Pathways Grass, Eriosema himalaicum Ohashi, Herba Eupatorii, Semen Cassiae Occidemtalis, Herba Parthenocissi Himalayanae, lobus cardiacus hops, Cortex Cinnamomi Burmannii and coriander.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Cynanchi Stauntonii 10-30 part, Pericarpium Arecae 10-30 part, Streptopus simplex D. Don 10-30 part, Massa Medicata Fermentata 5-15 part, Cicerbita cyanea (D. Don) beauverd 10-30 part, great Pi disappears 10-20 part, hangs fruit 10-20 part, Radix micheliae champacae 15-25 part, Lignum Dalbergiae Odoriferae 20-35 part, Herba Cichorii 20-40 part, Pathways Grass 15-30 part, Eriosema himalaicum Ohashi 25-40 part, Herba Eupatorii 10-30 part, Semen Cassiae Occidemtalis 5-25 part, Herba Parthenocissi Himalayanae 20-40 part, lobus cardiacus hops 20-40 part, Cortex Cinnamomi Burmannii 10-30 part and coriander 15-30 part.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Cynanchi Stauntonii 15-25 part, Pericarpium Arecae 15-25 part, Streptopus simplex D. Don 12-25 part, Massa Medicata Fermentata 5-10 part, Cicerbita cyanea (D. Don) beauverd 15-25 part, great Pi disappears 12-18 part, hangs fruit 12-18 part, Radix micheliae champacae 18-23 part, Lignum Dalbergiae Odoriferae 22-32 part, Herba Cichorii 25-35 part, Pathways Grass 18-25 part, Eriosema himalaicum Ohashi 28-35 part, Herba Eupatorii 18-23 part, Semen Cassiae Occidemtalis 12-18 part, Herba Parthenocissi Himalayanae 25-35 part, lobus cardiacus hops 25-35 part, Cortex Cinnamomi Burmannii 12-25 part and coriander 18-25 part.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Cynanchi Stauntonii 18 parts, Pericarpium Arecae 23 parts, Streptopus simplex D. Don 20 parts, Massa Medicata Fermentata 8 parts, Cicerbita cyanea (D. Don) beauverd 20 parts, great Pi disappears 16 parts, hangs fruit 16 parts, Radix micheliae champacae 18 parts, Lignum Dalbergiae Odoriferae 28 parts, Herba Cichorii 28 parts, Pathways Grass 20 parts, Eriosema himalaicum Ohashi 30 parts, Herba Eupatorii 19 parts, Semen Cassiae Occidemtalis 17 parts, Herba Parthenocissi Himalayanae 28 parts, lobus cardiacus hops 34 parts, Cortex Cinnamomi Burmannii 20 parts and coriander 19 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Cynanchi Stauntonii 22 parts, Pericarpium Arecae 20 parts, Streptopus simplex D. Don 22 parts, Massa Medicata Fermentata 7 parts, Cicerbita cyanea (D. Don) beauverd 15 parts, great Pi disappears 14 parts, hangs fruit 13 parts, Radix micheliae champacae 21 parts, Lignum Dalbergiae Odoriferae 26 parts, Herba Cichorii 33 parts, Pathways Grass 23 parts, Eriosema himalaicum Ohashi 28 parts, Herba Eupatorii 21 parts, Semen Cassiae Occidemtalis 14 parts, Herba Parthenocissi Himalayanae 32 parts, lobus cardiacus hops 27 parts, Cortex Cinnamomi Burmannii 22 parts and coriander 23 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, leave standstill 30 ~ 50 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

8. a preparation method for the Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:

The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, leave standstill 30 ~ 50 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.