CN105748847A - Traditional Chinese medicine preparation for treating ascites due to cirrhosis and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating ascites due to cirrhosis and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine preparation for treating ascites due to cirrhosis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the raw medicinal materials of lotus stems, cyclea hypoglauca, roots of diospyros kaki thunb, coralhead plant roots, bipinnatifid ginseng rhizomes, Chinese soapberry fruits, incarvillea arguta, patrinia rupestris, cinnamomum bodinieri, latouchea fokiensis, eurya japonica thunb, antenoron filiforme, hygrophila salicifolia, asystasiella chinensis, actinostemma tenerum, rhamnus leptophylla schneid, boschniakia himalaica, bauhinia championii, dicranopteris pedata and smilax nigrescens. The traditional Chinese medicine preparation disclosed by the invention has the benefits that the traditional Chinese medicine preparation can be matched with a conventional method of Western medicines for treating the ascites due to cirrhosis, so that the treatment effect of the conventional method of the Western medicines can be improved, and the traditional Chinese medicine preparation is free from toxic and side effects, takes effect quickly, and is simple in preparation technology.
Description
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine preparation treating cirrhotic ascites and preparation method thereof.
Background technology
Cirrhotic ascites refers to owing to hepatic disease causes liver inflammation repeatedly, fibrosis and liver cirrhosis formed after due to multiple pathological factor, as portal hypertension, hypoproteinemia, water-sodium retention etc. cause the clinical symptoms of intraperitoneal hydrops.Cirrhotic ascites is not an independent disease, but the common clinical of many hepatic disease latter stage at end (Decompensated stage).Cirrhotic ascites common disease is caused to have: B-mode, hepatitis C, alcoholic hepatitis, autoimmune hepatitis etc..Hepatic disease is once be developed to the cirrhotic ascites stage, and usually prompting liver cirrhosis has arrived Decompensated stage, if do not carried out active intervention treatment, poor prognosis.Liver cirrhosis is the main cause of disease causing ascites, and liver cirrhosis patient, once there is ascites, indicates that hardening has been enter into Decompensated stage (middle and advanced stage).Hepatic ascites is the clinical manifestation that liver cirrhosis is the most prominent；Decompensated stage patient more than 75% has ascites.The excessive retention that mechanism is sodium, water that ascites is formed, relevant with following abdominal cavity local factor and systemic factor.
Motherland's medical science thinks that this disease belongs to the category of " tympanites ", motherland's medical literature occurs the document about ascites, tympanites, as " General Treatise on the Cause and Symptoms of Diseases edema disease ascites time " is called: " this is gathered in interior by noxious water is depressed; make abdomen gradually big; to shake sound, normal tending to drink water, and skin is pitch-dark; as like swollen shape, name ascites is also "." Jing Yue's complete work swelling " is called: " teenager indulges in drinking without joint, becomes dropsy more "." Zhang Shi doctor logical " meaning: " people being addicted to drink, sick abdominal distention such as bucket, this damp-heat impairing the spleen obtained ... thus become the painful abdominal mass swollen ".Cirrhotic ascites belongs to Decompensated stage, and liver spleen kidney three is dirty in close relations.Hep is of a specified duration, can damage liver-yin first, cause deficiency of liver-YIN or deficiency of liver-blood, and The liver and the kidney have a common source, often causes the hepatic and renal YIN deficiency；Second insufficiency of the spleen day is very, dysfunction of the spleen in transportation, and causes retention of water-damp in the body.First then only lower limbs edema, then the splenopathy and kidney, kidney qi or kidney yang be also empty for a long time and being difficult water, and retention of water-damp in the body more very, causes formation dropsy, genus deficiency in origin and excess in superficiality eventually.Damp-stagnancy heat-transformation or original damp and hot pathogenic factor, damp and hot friendship is steamed, and sends out as YANG jaundice or makes original jaundice increase the weight of, with the passing of time can transfer YIN jaundice to.Deficiency-weakness of spleen-QI, failure to control blood circulation, or stagnant heat or hyperactivity of fire caused by deficiency of YIN, burn blood network or bleeding due to blood-heat, all may result in various hemorrhage.Sick hepatic and renal YIN deficiency day for a long time is very, the moon sun not processed or wind syndrome due to blood-deficiency, liver-wind stirring up internally, then, it is seen that the diseases such as asterixis, deficiency of spleen-YANG and kidneyYANG day is heavy, it is burnt that the heresy of turbid damp checks three, the clear key of upper illiteracy, or pathogenic fire derived from stagnation of liver-QI or heat formation from yin deficiency or damp-stagnancy heat-transformation, intimately decoct body fluid and become expectorant, type of phlegm-heat attacking the heart or the invasion of pericardium by evil, all can cause the disease such as delirium, coma.
Summary of the invention
The technical problem to be solved is in that, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of determined curative effect and the Chinese medicine preparation for the treatment of cirrhotic ascites free of toxic effects and preparation method thereof.
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine preparation treating cirrhotic ascites, described Chinese medicine preparation includes following raw medicinal material: Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis, Hygrophila salicifolia, Rhizoma seu herba Asystasiellae Chinensis, Lobed Actinostemma Herb, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), Rhizoma Xylanches Himalaicae, Folium Bauhihiae Championii, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. and iron wire Radix Clematidis.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Petiolus nelumbinis 30～40 parts, 5～15 parts of Radix Ilicis Asprellae rattan, Radix Kaki 15～25 parts, Radix Abri 20～30 parts, Rhizoma Panacis bipinnatifidi 15～30 parts, Fructus Sapindi Mukouossi 25～35 parts, suona horn spends 10～20 parts, Herba Patriniae Rupestris 15～25 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 20～30 parts, Radix limonii sinensis 10～20 parts, Ramulus et Folium Euryae Japonicae 5～15 parts, Radix Antenoronis Filiformis 15～30 parts, Hygrophila salicifolia 10～20 parts, Rhizoma seu herba Asystasiellae Chinensis 15～25 parts, Lobed Actinostemma Herb 20～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 25～35 parts, Rhizoma Xylanches Himalaicae 15～30 parts, Folium Bauhihiae Championii 15～25 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～20 parts and iron wire Radix Clematidis 25～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Petiolus nelumbinis 30～35 parts, 5～10 parts of Radix Ilicis Asprellae rattan, Radix Kaki 20～25 parts, Radix Abri 25～30 parts, Rhizoma Panacis bipinnatifidi 20～25 parts, Fructus Sapindi Mukouossi 30～35 parts, suona horn spends 10～15 parts, Herba Patriniae Rupestris 15～20 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 25～30 parts, Radix limonii sinensis 10～15 parts, Ramulus et Folium Euryae Japonicae 5～10 parts, Radix Antenoronis Filiformis 20～25 parts, Hygrophila salicifolia 10～15 parts, Rhizoma seu herba Asystasiellae Chinensis 20～25 parts, Lobed Actinostemma Herb 25～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 30～35 parts, Rhizoma Xylanches Himalaicae 20～25 parts, Folium Bauhihiae Championii 15～20 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～15 parts and iron wire Radix Clematidis 30～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Petiolus nelumbinis 32 parts, 9 parts of Radix Ilicis Asprellae rattan, Radix Kaki 21 parts, Radix Abri 29 parts, Rhizoma Panacis bipinnatifidi 22 parts, Fructus Sapindi Mukouossi 35 parts, suona horn spends 12 parts, Herba Patriniae Rupestris 18 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 26 parts, Radix limonii sinensis 15 parts, Ramulus et Folium Euryae Japonicae 6 parts, Radix Antenoronis Filiformis 25 parts, Hygrophila salicifolia 12 parts, Rhizoma seu herba Asystasiellae Chinensis 25 parts, Lobed Actinostemma Herb 27 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 35 parts, Rhizoma Xylanches Himalaicae 21 parts, Folium Bauhihiae Championii 18 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 12 parts and iron wire Radix Clematidis 35 parts.
When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:
The first step, Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis and Hygrophila salicifolia are mixed in proportion, add relative to the alcohol reflux that mixture 5～8 times amount determining alcohol is 80%～90% 2～3 times, each 3～5 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4～6 times amount water, boils 3～5 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1.5～3.8: 0.18～0.36.
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
Beneficial effects of the present invention: the Chinese medicine preparation of the present invention, it is possible to associating doctor trained in Western medicine conventional treatment cirrhotic ascites, it is possible to increase the therapeutic effect of doctor trained in Western medicine conventional method, has no side effect, and instant effect, preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation treating cirrhotic ascites, Chinese medicine preparation includes following raw medicinal material: Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis, Hygrophila salicifolia, Rhizoma seu herba Asystasiellae Chinensis, Lobed Actinostemma Herb, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), Rhizoma Xylanches Himalaicae, Folium Bauhihiae Championii, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. and iron wire Radix Clematidis.
The pharmacology of various raw medicinal materials is as follows:
Petiolus nelumbinis: [another name] Rhizoma Nelumbinis bar, seedpod of the lotus bar, Folium Nelumbinis obstruct.[source] comes from " book on Chinese herbal medicine is new again ".[source] medical material Ji Yuan: for petiole or the anthocaulus of nymphaeaceae plant lotus.Gather and store: summer, autumn gather, defoliation and the seedpod of the lotus, dry or using fresh herb.[nature and flavor] are bitter；Property is put down.[return through] spleen；Bladder warp.[function cures mainly] expelling summer-heat heat clearing away；Regulating QI to expel dampness.Main heat-damp in summer is uncomfortable in chest does not relax；Have loose bowels；Dysentery；Gonorrhea；Leukorrhagia.[extracts] " China's book on Chinese herbal medicine "
Radix Ilicis Asprellae rattan: [another name] Herba Anoectochili roxburghii, Radix cycleae hypoglaucae, post Eumeces Chinensis, Radix Sophorae Tonkinensis, Jasminum nervosum Lour, clam son rattan, JINSUOSHI, unipods Sapium sebiferum (L.) Roxb..[source] medical material Ji Yuan: for root or the rattan of menispermaceous plants powder vane rings rattan.Gather and store: the whole year all can gather, removing fibrous root or branch and leaf, cleaning, cutting, dry.[nature and flavor] are bitter；Cold.[return through] lung；Large intestine；Liver Channel.[function cures mainly] heat-clearing and toxic substances removing；Wind-expelling pain-stopping；Relieving stranguria by diuresis.Main anemopyretic cold；Cough；Laryngopharynx swelling and pain；Diphtheria；Acute toothache；Enteritis；Dysentery；Urinary tract infection and lithangiuria；Rheumatalgia；Sore swollen toxin；Venom.[extracts] " China's book on Chinese herbal medicine "
Radix Kaki: [another name] Vulpes Fructus Kaki root bark, Fructus Kaki are in root.[source] comes from Compendium of Material Medica.[source] medical material Ji Yuan: for root or the root bark of Ebenaceae plant Fructus Kaki.Gather and store: the 9-10 month excavates, cleaning；Using fresh herb or dry.[nature and flavor] are puckery；Property is put down.[function cures mainly] heat-clearing and toxic substances removing；Cooling blood for hemostasis.Main metrorrhagia；Dysentery；Hemorrhoid；Aranea carries on the back.[each discussion] 1. " detailed outline ": control metrorrhagia, dysentery, hematochezia.2. " conventional glossary of Herbs and Drugs among the people ": clearing away heat and cooling blood.Control haematemesis, hemorrhoid.[extracts] " China's book on Chinese herbal medicine "
Radix Abri: [source] medical material Ji Yuan: for the root of leguminous plant Semen Abri Precatorii.[nature and flavor] are sweet；Cool.[return through] lung；Gallbladder；Bladder warp.[function cures mainly] heat-clearing and toxic substances removing, diuresis.Main laryngopharynx swelling and pain, bronchitis, jaundice, hepatitis.[each discussion] 1, " Nanning City's medicine will ": cellulitis of harnessing the Yellow River.2, " Guangxi Chinese herbal medicine ": clearing away heat and promoting diuresis.Control laryngopharynx swelling and pain, hepatitis, bronchitis.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Panacis bipinnatifidi: [another name] button Radix Notoginseng, Rhizoma Coptidis Radix Notoginseng, floral leaf turn round son seven, floral leaf Radix Notoginseng, Herba Senecionis Chrysanthemoidis, pimple seven.[source] medical material Ji Yuan: for the rhizome of Araliaceae leatherleaf Rhizoma Panacis Japonici.[nature and flavor] mildly bitter flavor；Bitter；Slightly warm in nature.[function cures mainly] removing stasis to stop bleeding；Subduing swelling and relieving pain.Main spitting of blood；Spit blood；Epistaxis；Hematuria；Have blood in stool；Dysentery；Metrorrhagia；Traumatic hemorrhage；Menoxenia；Amenorrhea；Postnatal blood stasis is suffered from abdominal pain；Treating swelling and pain by traumatic injury；Impairment caused by overstrain lumbago；Chest and hypochondrium；Gastric abscess；Skin infection.[extracts] " China's book on Chinese herbal medicine "
Fructus Sapindi Mukouossi: [another name] wood trouble pearl, fertile, oil droplet, the Fructus Sapindi Mukouossi, circle soap, Arillus Longan soap, fruit of washing one's hands, oil suffer from soap, oily really.[source] comes from supplementary Amplifications of the Compendium of Materia Medica.[source] medical material Ji Yuan: for the seed of sapindaceous plant Fructus Sapindi Mukouossi.Gather and store: autumn harvesting ripe fruit, remove sarcocarp and peel, take seed and dry.[nature and flavor] are bitter；Pungent；Cold；Mild toxicity.[return through] heart；Lung meridian.[function cures mainly] heat clearing away；Eliminate the phlegm；Removing food stagnancy；Parasite killing.Main sore throat swells and ache；Lung-heat cough with asthma；Hoarseness；Dyspepsia；Infantile malnutrition；Ascarid is suffered from abdominal pain；Trichomonal vaginitis；Tinea；Toxic swelling.[extracts] " China's book on Chinese herbal medicine "
Suona horn flower: [another name] Herba Incarvilleae argutae, big gun is swollen cylinder, Radix et Rhizoma Thalictri, sheep tail grass, Salar flower, broken bowl is colored, big gun is swollen flower, Folium Cannabis are sub.[source] medical material Ji Yuan: for the band rhizome herb of Bignoniaceae tree planting thing Herba Melicae Scabrosae.[nature and flavor] bitter in the mouth；Micro-pungent；Property is put down.[function cures mainly] invigorating spleen to remove dampness；Promoting flow of QI and blood.Master has loose bowels；Dysentery；Stomachache；Hypochondriac pain；Rheumatalgia；Menoxenia；Carbuncle；Fracture.[extracts] " China's book on Chinese herbal medicine "
Herba Patriniae Rupestris: [source] medical material Ji Yuan: for the herb of Valerianaceae plant Herba Patriniae Rupestris.[nature and flavor] acrid in the mouth；Bitter；Cold in nature.[function cures mainly] heat-clearing and toxic substances removing；Invigorate blood circulation；Evacuation of pus.Main dysentery；Have loose bowels；Jaundice；Enterodynia.[extracts] " China's book on Chinese herbal medicine "
Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.): [another name] XIANGSHU, Radix Cinnamomi porrecti, monkey hold wood, big pepper tree under the arm.[source] medical material Ji Yuan: for the root bark of canella Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), peel of stem or branch and leaf.[nature and flavor] are pungent；Temperature.[return through] lung；Stomach warp.[function cures mainly] expelling wind and removing dampness；Warming spleen and stomach for dispelling cold；Promoting the circulation of QI to relieve pain.Main anemofrigid cold；Rheumatic arthralgia；Vomit and diarrhoea and suffer from abdominal pain, mass in abdomen；Hernia pain.[each discussion] " Guizhou medical herbs ": wind dispelling, circulation of qi promoting, warming middle-JIAO, analgesia.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Radix limonii sinensis: [another name] mother's honker leaf, red shrimp toad leaf.[source] medical material Ji Yuan: for the herb of gentianaceae plant Radix limonii sinensis.[nature and flavor] are bitter；Pungent；Cold in nature.[return through] lung；Liver；Large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling；Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen；Epersalgia cough.[extracts] " China's book on Chinese herbal medicine "
Ramulus et Folium Euryae Japonicae: [another name] blows wood leaf, spire dish, fishes Fructus Solani melongenae, spire tea.[source] comes from " Hunan medicine will ".[source] medical material Ji Yuan: for branch and leaf or the fruit of plant of theaceae Ramulus et Folium Euryae Japonicae.Gather and store: branch and leaf can be adopted the whole year, and fruit is adopted August, using fresh herb or dry.[nature and flavor] are bitter；Puckery；Cool.[return through] spleen；Bladder warp.[function cures mainly] expelling wind and clearing away heat；Inducing diuresis to remove edema；Hemostasia and promoting granulation.Main air pain of dampness syndrome；Ascites expands；Heating xerostomia；Skin ulcer swells；Treating swelling and pain by traumatic injury；Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Radix Antenoronis Filiformis: [another name] sea root, ferrum corner angle Radix Notoginseng, Cortex cynoglossi zeylanici radicis, Herba Lycianthis Biflorae, waterline flower root, knotweed seven, shorthairy antenoron root.[source] medical material Ji Yuan: for the rhizome of few section plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) and undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).[nature and flavor] are bitter；Pungent；Cold nature.[function cures mainly] cooling blood for hemostasis；Eliminating stasis to stop pain；Heat-clearing and toxic substances removing.Main cough spitting of blood；Spit blood；Metrorrhagia；Menoxenia；Dysmenorrhea；Epigastric pain；Have loose bowels；Dysentery；Traumatic injury；Rheumatic arthralgia；Scrofula；Swollen ulcer drug；Burn and scald；Biting of poison.[each discussion] 1, " Chinese herbal medicine is commonly used in Sichuan ": dissipating blood stasis circulation of qi promoting, reducing swelling and alleviating pain.Controlling traumatic injury, consumptive disease wound is spitted blood.2, Jiangxi " medical herbs handbook ": dissipating blood stasis stops blooding, detoxify promoting the circulation of QI.[extracts] " China's book on Chinese herbal medicine "
Hygrophila salicifolia: [another name] Herba Hygrophilae Salicifoliae, blue or green Herba Lycopi, side's arrow grass, water joint, lock medicine, Rhizoma seu Herba Elatostematis stewardii, fishbone grass, water Radix Gentianae.[source] medical material Ji Yuan: for the herb of acanthaceous plant Hygrophila salicifolia.[nature and flavor] sweet in the mouth；Micro-hardship；Cool in nature.[function cures mainly] heat-clearing and toxic substances removing；Dissipating blood stasis for subsidence of swelling.Row pyretic toxicity time main；Erysipelas；Jaundice；Aphtha；Coffee swells and ache；Acute mastitis；Tell nosebleed；Traumatic pain；Fracture；Venom.[extracts] " China's book on Chinese herbal medicine "
Rhizoma seu herba Asystasiellae Chinensis: [another name] Yulong's dish, bone free Boehmeria, beautiful synthetism, Herba Chenopodii Hybridi, beautiful money grass, kylin grass, Cortex torricelliae tiliifoliae.[source] medical material Ji Yuan: for the herb of rank of nobility dinner party section plant Rhizoma seu herba Asystasiellae Chinensis.[nature and flavor] bitter in the mouth；Light；Cool in nature.[return through] returns lung meridian.[function cures mainly] removing stasis to stop bleeding；Reunion of fractured tendons and bones；Inducing diuresis to remove edema；Heat-clearing and toxic substances removing.Main haematemesis；Have blood in stool；Traumatic hemorrhage；Traumatic injury congestive edema；Sprain fracture；Rheumatism limb swells；Ascites；Skin infection festers；Furuncle；Swollen；Laryngopharynx swelling and pain.[each discussion] 1, " Zhejiang traditional herbal medicine ": blood stasis removing.Control tetanus.2, " Zhejiang conventional medical herbs among the people ": heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.Control traumatic hemorrhage, sprain, furuncle and phyma, ulcer of the lower limb, ascites, pulmonary tuberculosis.[extracts] " China's book on Chinese herbal medicine "
Lobed Actinostemma Herb: [another name] Herba Actinstemmatis Lobati, Aicis galericulata Semen Momordicae, water Fructus Litchi, box rattan, celestial sphere grass, Gui Ercao, without Pennisetum centrasiaticum Tzvel, calabash basket stalk, Huang Siteng, horse melon parcel, silk screen grass of crawling, to break bowl rattan, wild melon vine, soup can grass, wild Fructus Momordicae charantiae, eczema careless.[source] medical material Ji Yuan: for herb or the seed of cucurbitaceous plant Lobed Actinostemma Herb.Gather and store: summer, herb of gathering in season in autumn two, drying.Gather autumn mature fruit, collect seed, dry.[nature and flavor] bitter in the mouth；Cold in nature.[return through] returns kidney；Bladder warp.[function cures mainly] inducing diuresis to remove edema；Heat-clearing and toxic substances removing.Main edema；Tympanites；Infantile malnutrition；Eczema；Skin infection；Venom.[extracts] " China's book on Chinese herbal medicine "
Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.): [another name] shoot son, cry pear, Cornu Cervi bur, cry ear mothers and sons, money, thunder-crash bomb, Fructus Jujubae.[source] medical material Ji Yuan: for the fruit of Rhamnaceae plant fineflower buckthorn.[nature and flavor] are bitter；Puckery；Flat.[return through] heart；Spleen；Kidney channel.[function cures mainly] relieving dyspepsia；Row water can be just.Main dyspeptic abdominal distention；Edema；Ascites；Constipation.[each discussion] " Kweiyang medicinal herbs among the people ": relieve oedema or abdominal distension through diuresis or purgation, detumescence, relieving constipation.Control food stagnation, tympanites, constipation.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Xylanches Himalaicae: [another name] Herba Boschniakiae Rossicae, Folium Eriobotryae attached, film, obscure Poria, Western Regions fourth seat grass, a Rhizoma Pinelliae heavy, very heavy beautiful, very heavy.[source] comes from " Shaanxi Chinese herbal medicine will "." Shaanxi Chinese herbal medicine ": the Rhizoma Xylanches Himalaicae property of medicine is fierce, can not be multiplex, multiplex then dizzy.[source] medical material Ji Yuan: for the tuber of Orobanchaceae plant fourth seat grass.Gather and store: adopting when sending out Seedling early summer, dry.[nature and flavor] acrid in the mouth；Micro-hardship；Warm in nature；Mild toxicity.[function cures mainly] the kidney warming dehumidifies；Vital energy regualting and blood circulation-promoting；Parasite killing detoxifies.Main soreness of waist and knee joint of suffering from a deficiency of the kidney；Migratory arthralgia pain；Abdominal distention；Hernia；Traumatic injury；Menoxenia；Epersalgia cough；Schistosomicide；Carbuncle sore ulcer；Laryngopharynx swelling and pain；Rib adenitis.[each discussion] 1. " Shaanxi Chinese herbal medicine ": regulating QI to relieve pain, relieving cough and resolving phlegm, relieving distension stomach invigorating.Control abdominal distention, stomachache, hernia, epersalgia cough.2. " Chinese herbal medicine is commonly used in Tibet ": reinforcing the kidney and supporting YANG, bone and muscle strengthening.Control pain in the low back and legs, sexual impotence.[extracts] " China's book on Chinese herbal medicine "
Folium Bauhihiae Championii: [another name] swallow tail, Ungula Sus domestica fork, silk tree grass, thousand dozens beat, Herba Calthae.[source] medical material Ji Yuan: for the leaf of leguminous plant Caulis Bauhiniae Championii.[nature and flavor] are sweet；Bitter；Flat.[return through] Liver Channel.[function cures mainly] diuresis, blood stasis dispelling, regulating QI to relieve pain.Main dysuria, lumbago, traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook.: [another name] mountain fern, louse Bin grass, wear road beanstalk, chicken feather Herba pteridii latiusculi, pail beanstalk fern leaf purple, anti-, hard Herba pteridii latiusculi beanstalk, fern leaf grass.[source] medical material Ji Yuan: for the spire of Diplopterygium glaucum (Thunb ex Houtt) Nakai section plant Dicranopteris dichotoma, petiole.[nature and flavor] are bitter；Puckery；Cool in nature.[return through] liver；Bladder warp.[function cures mainly] removing stasis to stop bleeding；Clearing away heat and promoting diuresis；Removing toxic substances and promoting subsidence of swelling.Main metrorrhagia；Traumatic injury；The puckery pain of pyretic stranguria；Leucorrhea；Infantile diarrhea；Hemorrhoid complicated by anal fistula；Conjunctival congestion and swelling pain；Traumatic hemorrhage；Burn and scald；Insect-bite.[each discussion] 1, " Fujian traditional herbal medicine ": the stasis of blood of living hemostasis, diuresis is antipyretic.2, " Luchuan book on Chinese herbal medicine ": hemostasis, granulation promoting, circulation of qi promoting.Control knife injury hemorrhage, suppurating sore, hernia.[extracts] " China's book on Chinese herbal medicine "
Iron wire Radix Clematidis: [another name] iron wire root, iron Radix Clematidis, radix smilacis sieboldi.[source] medical material Ji Yuan: for the root and rhizome of liliaceous plant short stalk Rhizoma Smilacis Chinensis, East China Rhizoma Smilacis Chinensis, smilax nigrescens Wang et Tang and sheath handle Rhizoma Smilacis Chinensis.[nature and flavor] are pungent；Micro-hardship；Flat.[function cures mainly] expelling wind and removing dampness；Promoting blood circulation to remove obstruction in the collateral；Detoxicating and resolving stagnation of pathogens.Main air pain of dampness syndrome；Articular instability；Furuncle；Toxic swelling；Scrofula [extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can be preferably: Petiolus nelumbinis 30～40 parts, 5～15 parts of Radix Ilicis Asprellae rattan, Radix Kaki 15～25 parts, Radix Abri 20～30 parts, Rhizoma Panacis bipinnatifidi 15～30 parts, Fructus Sapindi Mukouossi 25～35 parts, suona horn spends 10～20 parts, Herba Patriniae Rupestris 15～25 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 20～30 parts, Radix limonii sinensis 10～20 parts, Ramulus et Folium Euryae Japonicae 5～15 parts, Radix Antenoronis Filiformis 15～30 parts, Hygrophila salicifolia 10～20 parts, Rhizoma seu herba Asystasiellae Chinensis 15～25 parts, Lobed Actinostemma Herb 20～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 25～35 parts, Rhizoma Xylanches Himalaicae 15～30 parts, Folium Bauhihiae Championii 15～25 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～20 parts and iron wire Radix Clematidis 25～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Petiolus nelumbinis 30～35 parts, 5～10 parts of Radix Ilicis Asprellae rattan, Radix Kaki 20～25 parts, Radix Abri 25～30 parts, Rhizoma Panacis bipinnatifidi 20～25 parts, Fructus Sapindi Mukouossi 30～35 parts, suona horn spends 10～15 parts, Herba Patriniae Rupestris 15～20 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 25～30 parts, Radix limonii sinensis 10～15 parts, Ramulus et Folium Euryae Japonicae 5～10 parts, Radix Antenoronis Filiformis 20～25 parts, Hygrophila salicifolia 10～15 parts, Rhizoma seu herba Asystasiellae Chinensis 20～25 parts, Lobed Actinostemma Herb 25～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 30～35 parts, Rhizoma Xylanches Himalaicae 20～25 parts, Folium Bauhihiae Championii 15～20 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～15 parts and iron wire Radix Clematidis 30～35 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine preparation can also be more preferably: Petiolus nelumbinis 32 parts, 9 parts of Radix Ilicis Asprellae rattan, Radix Kaki 21 parts, Radix Abri 29 parts, Rhizoma Panacis bipinnatifidi 22 parts, Fructus Sapindi Mukouossi 35 parts, suona horn spends 12 parts, Herba Patriniae Rupestris 18 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 26 parts, Radix limonii sinensis 15 parts, Ramulus et Folium Euryae Japonicae 6 parts, Radix Antenoronis Filiformis 25 parts, Hygrophila salicifolia 12 parts, Rhizoma seu herba Asystasiellae Chinensis 25 parts, Lobed Actinostemma Herb 27 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 35 parts, Rhizoma Xylanches Himalaicae 21 parts, Folium Bauhihiae Championii 18 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 12 parts and iron wire Radix Clematidis 35 parts.
When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:
The first step, Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis and Hygrophila salicifolia are mixed in proportion, add relative to the alcohol reflux that mixture 5～8 times amount determining alcohol is 80%～90% 2～3 times, each 3～5 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4～6 times amount water, boils 3～5 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1.5～3.8: 0.18～0.36.
When the dosage form of described Chinese medicine preparation is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1: tablet prepared by the present invention
Take Petiolus nelumbinis 350g, Radix Ilicis Asprellae rattan 70g, Radix Kaki 230g, Radix Abri 260g, Rhizoma Panacis bipinnatifidi 250g, Fructus Sapindi Mukouossi 320g, suona horn flower 150g, Herba Patriniae Rupestris 150g, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 290g, Radix limonii sinensis 120g, Ramulus et Folium Euryae Japonicae 90g, Radix Antenoronis Filiformis 230g, Hygrophila salicifolia 150g, Rhizoma seu herba Asystasiellae Chinensis 220g, Lobed Actinostemma Herb 290g, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 320g, Rhizoma Xylanches Himalaicae 240g, Folium Bauhihiae Championii 170g, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 150g and iron wire Radix Clematidis 310g.
Its preparation method comprises the following steps:
The first step, Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis and Hygrophila salicifolia are mixed in proportion, add relative to the alcohol reflux that mixture 7 times amount determining alcohol is 80%～90% 2 times, each 4 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times amount water, boils 5 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.29；
3rd step, the mastic mixing first step, second step obtained, 60 DEG C of reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 3.3: 0.34.
Embodiment 2: granule prepared by the present invention
Take Petiolus nelumbinis 320g, Radix Ilicis Asprellae rattan 90g, Radix Kaki 210g, Radix Abri 290g, Rhizoma Panacis bipinnatifidi 220g, Fructus Sapindi Mukouossi 350g, suona horn flower 120g, Herba Patriniae Rupestris 180g, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 260g, Radix limonii sinensis 150g, Ramulus et Folium Euryae Japonicae 60g, Radix Antenoronis Filiformis 250g, Hygrophila salicifolia 120g, Rhizoma seu herba Asystasiellae Chinensis 250g, Lobed Actinostemma Herb 270g, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 350g, Rhizoma Xylanches Himalaicae 210g, Folium Bauhihiae Championii 180g, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 120g and iron wire Radix Clematidis 350g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 85% relative to 5 times of mixture, heat to boiling reflux 5 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 2ml per minute, collect percolate, being evaporated to relative density when 55 DEG C subsequently under vacuum 0.08Mpa is the mastic of 1.05, spray drying, the inlet temperature of spray dryer 165 DEG C, leaving air temp 85 DEG C, it is ground into powder subsequently, makes dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.3 times and 0.2 times in the dried cream powder obtained, make granule, dries in 45 DEG C, it is thus achieved that granule.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20～36g, carries out acute toxicity test.Mice is randomly divided into two groups, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 43.7 crude drugs/kg), and matched group gives normal saline, within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Tablet LD50 > 43.7 crude drugs/the kg of the Mouse oral gavage present invention, every day, maximum dosage-feeding was 87.4 crude drugs/kg/ day.The Chinese medicine clinical application amount of the present invention be 8.43g crude drug/day/people, adult body weight in 60KG, average dosage is 0.141g crude drug/kg/ day.By weighing machine: 620 times that the dosis tolerata of the Chinese medicine of mice (average weight with 28g) the oral administration gavage present invention is quantity.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention to three groups of mices (often group 20) by 14.29,23.57 and 42.73g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by Chinese medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, Organs of Mice is all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, react also without difference after drug withdrawal, application safety.
Clinical data:
Case selection: all 116 selected example cases derive from this Out-patient Department and the patients with cirrhosis ascites being in hospital, and all meet the diagnostic criteria of cirrhotic ascites.All patients are all through abdominal part ultrasound diagnosis, liver function test, and some cases confirms through abdominal part CT examination.Above patient is randomly divided into two groups, treatment group and each 58 examples of matched group.In treatment group 58 example, male 37 examples, female 21 example；28～71 years old age, year mean age (48.27 ± 4.39)；Liver cirrhosis type: posthepatitic cirrhosis 33 example, alcoholic cirrhosis 18 example, other 7 examples.In matched group 58 example, male 42 examples, female 16 example；29～70 years old age, year mean age (48.59 ± 3.94)；Liver cirrhosis type: posthepatitic cirrhosis 32 example, alcoholic cirrhosis 19 example, other 7 examples.Treatment group compares without statistics with matched group in sex, age, liver cirrhosis type and clinical symptoms etc., has comparability.
Diagnostic criteria:
One, Properties of Ascites is omission timber.
Two, there is the sign of chronic hepatopathy and liver cirrhosis, such as liver palm, spider angioma, gynaecomastia, menoxenia, sometimes visible abdominal wall varicosis.
Three, endoscopy or esophagus gulp down barium x-ray and take the photograph sheet display esophageal varicosis.
Four, B ultrasonic or CT show the sign of liver cirrhosis, as out of proportion in liver profile not finishing, nodositas, lobe of the liver etc..
Five, blood biochemical detection shows that serum albumin reduces, normally low in every liter of 30g.
Therapeutic Method:
Matched group: give western medicine routine treatment, including allowing patient lie up, reasonable diet (gives rich in vitamin, high heat, high protein, the diet that easy to digest, nonirritant, cellulose are few), controls the absorption of water and sodium salt；According to patient's liver function situation, give the liver protecting therapies such as Diammonium Glycyrrhizinate, reduced glutathion, ademetionine, motassium magnessium aspartate；Giving spironolactone to be administered orally, 40mg/ time, 3 times/d, poor effect person combines furosemide 20mg/ time～40mg/ time；Human albumin 5g/ time～10g/ time, 2 times/w～3 time/w, intravenous drip or interval use blood plasma 100ml/ (secondary d)～200ml (secondary d) intravenous drip.Merge ascites the infected, select third-generation cephalosporin or quinolones treatment；Give abdominal paracentesis if desired and put ascites decompression；2 courses for the treatment of Monday, treat 4 courses for the treatment of.
Treatment group: on matched group western medicine routine treatment basis, treatment group patient is oral Chinese medicine embodiment 1 tablet of the present invention simultaneously, each 4, every day 3 times；2 courses for the treatment of Monday, treat 4 courses for the treatment of.
Curative effect judging standard: clinical cure: clinical symptom disappearance, liver function recovery is normal, and ultrasound diagnosis shows that ascites disappears.Take a turn for the better: clinical cardinal symptom disappears or is clearly better, and liver function takes a turn for the better, and ultrasound diagnosis shows that ascites reduces, but is not wholly absent.Invalid: clinical symptoms is without improving or increasing the weight of, and ultrasound diagnosis shows that ascites is without reducing or increasing, and liver function is without improving or worsening.
Therapeutic outcome: two groups treat 8 weeks respectively after, statistical result is referring to table 1 and table 2.
Clinical efficacy comparison (unit: example) after treating respectively 8 weeks organized by 1 liang of table
| Group | Number of cases | Clinical cure | Take a turn for the better | Invalid | Total effective rate |
| Treatment group | 58 | 39 | 16 | 3 | 55 (94.83%) |
| Matched group | 58 | 30 | 18 | 10 | 48 (82.76%) |
As it can be seen from table 1 treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment cirrhotic ascites, relative to matched group, on therapeutic effect, have and be markedly improved.
After the group treatment of 2 liang of table, clinical cure number and time compare (unit: example/%)
| Group | Number of cases | Medication 4 weeks | Medication 6 weeks | Medication 8 weeks |
| Treatment group | 39 | 19 (32.76%) | 28 (48.28%) | 39 (67.24%) |
| Matched group | 30 | 12 (20.69%) | 20 (34.48%) | 30 (51.72%) |
From table 2 it can be seen that treatment group adopts the Chinese medicine of the present invention, coordinate western medical treatment cirrhotic ascites, relative to matched group, not only better efficacy, takes effect also faster.
Concrete case: permitted certain, man, 52 years old, patient had hepatitis B history, and patient is because there is abdominal distention, anorexia in two weeks, abdominal distention after meal is more severe, and edema of lower limbs is admitted to hospital and is sought medical advice.Ultrasound diagnosis is pointed out: cirrhotic ascites.Liver function test is abnormal, the prompting slight varicose of esophageal veins of x-ray canel barium meal contrast examination, the prompting gastric fundus vein moderate varicose of fiber esophagogastroscope.It is diagnosed as cirrhotic ascites.Take western medicine routine treatment, simultaneously the tablet of oral inventive embodiments 1, each 4, every day 3 times.After treating 3 weeks, clinical symptom disappearance, liver function recovery is normal, and ultrasound diagnosis shows that ascites disappears, and clinical cure stops Western medicine, continues the drug withdrawal in 1 week that takes traditional Chinese medicine, and follows up a case by regular visits to 6 months without recurrence.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement or the new method that limit other forms.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, and any those skilled in the art are changed or be modified as the Equivalent embodiments of equivalent variations possibly also with the technology contents of the disclosure above.But every without departing from technical solution of the present invention content, according to any simple modification, equivalent variations and remodeling that above example is made by the technical spirit of the present invention, still fall within the protection domain of technical solution of the present invention.
Claims (8)
1. the Chinese medicine preparation treating cirrhotic ascites, it is characterized in that, described Chinese medicine preparation includes following raw medicinal material: Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis, Hygrophila salicifolia, Rhizoma seu herba Asystasiellae Chinensis, Lobed Actinostemma Herb, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.), Rhizoma Xylanches Himalaicae, Folium Bauhihiae Championii, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. and iron wire Radix Clematidis.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Petiolus nelumbinis 30～40 parts, 5～15 parts of Radix Ilicis Asprellae rattan, Radix Kaki 15～25 parts, Radix Abri 20～30 parts, Rhizoma Panacis bipinnatifidi 15～30 parts, Fructus Sapindi Mukouossi 25～35 parts, suona horn spends 10～20 parts, Herba Patriniae Rupestris 15～25 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 20～30 parts, Radix limonii sinensis 10～20 parts, Ramulus et Folium Euryae Japonicae 5～15 parts, Radix Antenoronis Filiformis 15～30 parts, Hygrophila salicifolia 10～20 parts, Rhizoma seu herba Asystasiellae Chinensis 15～25 parts, Lobed Actinostemma Herb 20～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 25～35 parts, Rhizoma Xylanches Himalaicae 15～30 parts, Folium Bauhihiae Championii 15～25 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～20 parts and iron wire Radix Clematidis 25～35 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Petiolus nelumbinis 30～35 parts, 5～10 parts of Radix Ilicis Asprellae rattan, Radix Kaki 20～25 parts, Radix Abri 25～30 parts, Rhizoma Panacis bipinnatifidi 20～25 parts, Fructus Sapindi Mukouossi 30～35 parts, suona horn spends 10～15 parts, Herba Patriniae Rupestris 15～20 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 25～30 parts, Radix limonii sinensis 10～15 parts, Ramulus et Folium Euryae Japonicae 5～10 parts, Radix Antenoronis Filiformis 20～25 parts, Hygrophila salicifolia 10～15 parts, Rhizoma seu herba Asystasiellae Chinensis 20～25 parts, Lobed Actinostemma Herb 25～30 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 30～35 parts, Rhizoma Xylanches Himalaicae 20～25 parts, Folium Bauhihiae Championii 15～20 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 10～15 parts and iron wire Radix Clematidis 30～35 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of described raw medicinal material is: Petiolus nelumbinis 32 parts, 9 parts of Radix Ilicis Asprellae rattan, Radix Kaki 21 parts, Radix Abri 29 parts, Rhizoma Panacis bipinnatifidi 22 parts, Fructus Sapindi Mukouossi 35 parts, suona horn spend 12 parts, Herba Patriniae Rupestris 18 parts, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.) 26 parts, Radix limonii sinensis 15 parts, Ramulus et Folium Euryae Japonicae 6 parts, Radix Antenoronis Filiformis 25 parts, Hygrophila salicifolia 12 parts, Rhizoma seu herba Asystasiellae Chinensis 25 parts, Lobed Actinostemma Herb 27 parts, Fructus rhamni leptophyllae (Rhamnus leptophylla Schneid.) 35 parts, Rhizoma Xylanches Himalaicae 21 parts, Folium Bauhihiae Championii 18 parts, Dicranopteris dichotoma (Thunb.) Bernh.(Gleichnia dichotoma Hook. 12 parts and iron wire Radix Clematidis 35 parts.
5. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step, Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis and Hygrophila salicifolia are mixed in proportion, add relative to the alcohol reflux that mixture 5～8 times amount determining alcohol is 80%～90% 2～3 times, each 3～5 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4～6 times amount water, boils 3～5 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1.5～3.8: 0.18～0.36.
6. the Chinese medicine preparation as described in Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
7. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step, Petiolus nelumbinis, Radix Ilicis Asprellae rattan, Radix Kaki, Radix Abri, Rhizoma Panacis bipinnatifidi, Fructus Sapindi Mukouossi, suona horn flower, Herba Patriniae Rupestris, Cortex cinnamomi bodinieri radicis (Cinnamomum bodnieri Levl.), Radix limonii sinensis, Ramulus et Folium Euryae Japonicae, Radix Antenoronis Filiformis and Hygrophila salicifolia are mixed in proportion, add relative to the alcohol reflux that mixture 5～8 times amount determining alcohol is 80%～90% 2～3 times, each 3～5 hours, filtering, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30～1.32, standby；
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 4～6 times amount water, boils 3～5 hours, filters, and being concentrated into 70 DEG C of relative densities is the mastic of 1.27～1.29；
3rd step, the mastic mixing first step, second step obtained, 55 DEG C～65 DEG C reduced vacuum dry, and get dry extract powder；
4th step, carries out mixing process by described dried cream powder and starch, obtains mastic mixture；Described mastic and the weight ratio of starch are 1: 0.01～0.02；Described mastic mixture is carried out pelletization treatment, dried, the mastic compound particles obtained；
5th step, is sequentially carried out described mastic compound particles and Pulvis Talci, magnesium stearate mixing process, tabletting process, Cotton seeds, obtains Chinese medicine preparation tablet finished product；Described granule, Pulvis Talci, magnesium stearate weight ratio be 100: 1.5～3.8: 0.18～0.36.
8. the preparation method of the Chinese medicine preparation described in a Claims 1-4, it is characterised in that the dosage form of described Chinese medicine preparation is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, add the ethanol that determining alcohol is 80%～95% relative to 5～6 times of mixture, heat to boiling reflux 4～6 hours, filter, with backflow for solvent, with filtering residue for solute, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, being evaporated to relative density when 50～60 DEG C subsequently under vacuum 0.06～0.08Mpa is the mastic of 1.05～1.10, spray drying, the inlet temperature of spray dryer 160～175 DEG C, leaving air temp 80～85 DEG C, it is ground into powder subsequently, make dried cream powder；
Step 2: add the dextrin of the cane sugar powder relative to dried cream powder quality 0.2～0.4 times and 0.1～0.2 times in the dried cream powder obtained, make granule, dries in 40～50 DEG C, it is thus achieved that granule.
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610309102.0A Pending CN105748847A (en) | 2016-05-10 | 2016-05-10 | Traditional Chinese medicine preparation for treating ascites due to cirrhosis and preparation method of traditional Chinese medicine preparation |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291504A (en) * | 1999-08-27 | 2001-04-18 | 王天会 | Medicine for treating cirrhosis ascites |
| CN1304744A (en) * | 2000-10-21 | 2001-07-25 | 郑国芃 | Chinese medicine for curing hepatitis B and cirrhosis ascites |
| CN103977361A (en) * | 2014-06-04 | 2014-08-13 | 张跃鹏 | Traditional Chinese medicine for treating ascites caused by cirrhosis and preparation method thereof |
| CN104906471A (en) * | 2015-07-10 | 2015-09-16 | 冉宇欣 | Medicine composition for treating cyclomastopathy and preparation method thereof |
-
2016
- 2016-05-10 CN CN201610309102.0A patent/CN105748847A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1291504A (en) * | 1999-08-27 | 2001-04-18 | 王天会 | Medicine for treating cirrhosis ascites |
| CN1304744A (en) * | 2000-10-21 | 2001-07-25 | 郑国芃 | Chinese medicine for curing hepatitis B and cirrhosis ascites |
| CN103977361A (en) * | 2014-06-04 | 2014-08-13 | 张跃鹏 | Traditional Chinese medicine for treating ascites caused by cirrhosis and preparation method thereof |
| CN104906471A (en) * | 2015-07-10 | 2015-09-16 | 冉宇欣 | Medicine composition for treating cyclomastopathy and preparation method thereof |
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Application publication date: 20160713 |