CN104873704A - Traditional Chinese medicine for treating acute cystitis with deficiency of spleen qi and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating acute cystitis with deficiency of spleen qi and a preparation method thereof. The traditional Chinese medicine comprises the following raw materials: solanum vine, herba achyranthis asperae, wandering jew, leaf of shrubby baeckea, cucumber stem, belladonna leaf, polycarpae, honewort, quercophyllum leaf, cattail, althaea rosa, pondweed, Chinese redbud, selfheal spike, fimbristylis dichotoma, daghestan sweet clover herb, eleusine indica and eranthis pinnatifida. The traditional Chinese medicine has accurate treatment effect on acute cystitis with deficiency of spleen qi; the traditional Chinese medicine is small in toxic and side effects, and low in adverse reaction.

Description

A kind ofly treat Chinese medicine of insufficiency of spleen-qi type acute cystitis and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating Chinese medicine of insufficiency of spleen-qi type acute cystitis and preparation method thereof.

Background technology

Acute cystitis is the acute inflammation caused by escherichia coli etc., and pathogenic bacteria often per urethram goes upward to bladder this disease caused, and women is more than male.The cause of disease of cystitis is a lot, but great majority are pyogenic baeceria infection, and inducement has calculus, foreign body, tumor or obstructive pulmonary disease, comprises because nervous system disease produces urinary dysfunction etc.

Western medical treatment acute cystitis many employings levofloxacin magnitude broad spectrum antibiotic, though there is good therapeutic effect, but injury in various degree can be caused to nervous system, digestive system, blood vessel etc., cause many patients to take and can occur the malaise symptoms such as Nausea and vomiting, headache, dizziness, thus Patient drug's tolerance level is reduced, be unfavorable for treatment.

Acute cystitis belongs to the traditional Chinese medical science " stranguria " category.The cause of disease is many pents up bladder by invade in damp and hot or damp-heat in middle-JIAO is betted, cause functioning of bladder can not, the gas difficulty in urination, and occur the diseases such as urine urgency-frequency, scorching hot twinge, lumbago tenderness, urine red complexion be yellow.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind ofly to treat Chinese medicine of insufficiency of spleen-qi type acute cystitis and preparation method thereof, and Chinese medicine of the present invention has definite curative effect to insufficiency of spleen-qi type acute cystitis, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of insufficiency of spleen-qi type acute cystitis, its raw medicinal material comprises: Herba Solani Lyrati, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba Zebrinae Pendulae, Folium Baeckeae, Caulis Cucumidis sativiv, Folium Hyoscyami, Herba Polycarpaeae Corymbosae, Herba abutili indici, Folium Querci dentatae ， Rhizoma typhae, Semen althaeae roseae, Herba potamogetonis distincti, Lignum cercis chinensis, Spica Prunellae, Herba Fimbristylis dichotomae, Herba Meliloti Suaveolentis, Herba Oxalidis Strictae and Herba Malvae parviflorae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Solani Lyrati 30 ~ 40 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 25 parts, Herba Zebrinae Pendulae 15 ~ 25 parts, Folium Baeckeae 5 ~ 15 parts, Caulis Cucumidis sativiv 10 ~ 20 parts, Folium Hyoscyami 5 ~ 15 parts, Herba Polycarpaeae Corymbosae 5 ~ 15 parts, Herba abutili indici 30 ~ 40 parts, Folium Querci dentatae 10 ~ 20 parts of Rhizoma typhae 15 ~ 25 parts, Semen althaeae roseae 5 ~ 15 parts, Herba potamogetonis distincti 10 ~ 20 parts, Lignum cercis chinensis 10 ~ 20 parts, Spica Prunellae 15 ~ 25 parts, Herba Fimbristylis dichotomae 30 ~ 40 parts, Herba Meliloti Suaveolentis 5 ~ 15 parts, Herba Oxalidis Strictae 15 ~ 25 parts and Herba Malvae parviflorae 5 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Solani Lyrati 30 ~ 35 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Herba Zebrinae Pendulae 15 ~ 20 parts, Folium Baeckeae 5 ~ 10 parts, Caulis Cucumidis sativiv 10 ~ 15 parts, Folium Hyoscyami 5 ~ 10 parts, Herba Polycarpaeae Corymbosae 5 ~ 10 parts, Herba abutili indici 30 ~ 35 parts, Folium Querci dentatae 10 ~ 15 parts of ， Rhizoma typhae 15 ~ 20 parts, Semen althaeae roseae 5 ~ 10 parts, Herba potamogetonis distincti 10 ~ 15 parts, Lignum cercis chinensis 10 ~ 15 parts, Spica Prunellae 15 ~ 20 parts, Herba Fimbristylis dichotomae 30 ~ 35 parts, Herba Meliloti Suaveolentis 5 ~ 10 parts, Herba Oxalidis Strictae 15 ~ 20 parts and Herba Malvae parviflorae 5 ~ 10 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Solani Lyrati 33 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 16 parts, Herba Zebrinae Pendulae 19 parts, Folium Baeckeae 6 parts, Caulis Cucumidis sativiv 11 parts, Folium Hyoscyami 8 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 32 parts, Folium Querci dentatae 13 parts of Rhizoma typhae 18 parts, Semen althaeae roseae 7 parts, Herba potamogetonis distincti 11 parts, Lignum cercis chinensis 14 parts, Spica Prunellae 20 parts, Herba Fimbristylis dichotomae 32 parts, Herba Meliloti Suaveolentis 5 parts, Herba Oxalidis Strictae 16 parts and Herba Malvae parviflorae 6 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Solani Lyrati 31 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Herba Zebrinae Pendulae 15 parts, Folium Baeckeae 8 parts, Caulis Cucumidis sativiv 15 parts, Folium Hyoscyami 5 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 35 parts, Folium Querci dentatae 10 parts of Rhizoma typhae 16 parts, Semen althaeae roseae 10 parts, Herba potamogetonis distincti 13 parts, Lignum cercis chinensis 10 parts, Spica Prunellae 15 parts, Herba Fimbristylis dichotomae 35 parts, Herba Meliloti Suaveolentis 10 parts, Herba Oxalidis Strictae 20 parts and Herba Malvae parviflorae 9 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to insufficiency of spleen-qi type acute cystitis, and toxic and side effects is little, untoward reaction rate is low.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of insufficiency of spleen-qi type acute cystitis, its raw medicinal material comprises: Herba Solani Lyrati, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba Zebrinae Pendulae, Folium Baeckeae, Caulis Cucumidis sativiv, Folium Hyoscyami, Herba Polycarpaeae Corymbosae, Herba abutili indici, Folium Querci dentatae ， Rhizoma typhae, Semen althaeae roseae, Herba potamogetonis distincti, Lignum cercis chinensis, Spica Prunellae, Herba Fimbristylis dichotomae, Herba Meliloti Suaveolentis, Herba Oxalidis Strictae and Herba Malvae parviflorae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Herba Solani Lyrati: [another name] membrane inside the rush stalk (" elegant "), Herba Solani Lyrati, paddy dish (" herbal classic "), Herba Solani Lyrati (" elegant " Guo Pu note), Pennisetum centrasiaticum Tzvel (" not Lu "), air draft, white curtain (supplement to the Herbal), Fructus Solani Lyrati dish (" Wu Zhi "), Herba Bryophylli Pinnati, shaven head grass (" detailed outline is picked up any lost article from the road "), hope that the winter is red, the sharp dish of acid (" Zhiwu Mingshi Tukao "), Solanum lyratum Thunb. (" classifying herbal "), soil Radix Saposhnikoviae, ear pendant dish (" Guizhou side's medicine among the people collection "), gold thread mossback grass, calabash grass (" Fujian traditional herbal medicine "), hair Radix seu Caulis fici Martinii (" Jiangxi traditional herbal medicine "), hair old man (" Jiangxi Chinese medicine "), red-way scholar, hair Buddhist monk (" Zhejiang traditional herbal medicine "), wildcat ear (" Traditional Chinese Medicine in Sichuan will "), hair rattan recklessly, the young ear of sheep, the setation tip, dragon hair Testudinis, hair swallow is young, red wheat standing grain (" east, Fujian book on Chinese herbal medicine ").[source] is the herb of plant of Solanaceae Herba Solani Lyrati.Generally between 5 ~ June or 9 ~ November, extract herb, clean and dry.[nature and flavor] sweetness and bitterness, cold.[function cures mainly] heat clearing away, dampness removing, dispels the wind, removing toxic substances.Treating malaria disease, jaundice, edema, gonorrhea, rheumatic arthritis, erysipelas, furuncle.[extracts] " Chinese medicine voluminous dictionary "

Radix achyranthis asperae (Herba Achyranthis Asperae): [another name] cow tongue Radix Et Rhizoma Rhei, Sonchus arvensis L., Blainvillea acmell. (L.) Philipson. (" south of the Five Ridges gather medicinal herbs record "), barb grass, obstruct grass (" Guangzhou flora "), rag glues, white base Radix Achyranthis Bidentatae, Herba Abri (" Fujian traditional herbal medicine "), Radix Achyranthis Bidentatae wind, white Radix Achyranthis Bidentatae, goose knee joint (" Guangxi Chinese veterinarian's medicine is planted "), smooth out with the fingers grass (" Nanning City's medicine will "), gulp down, Asplenium normale Don (" wild medicine is planted figure and said "), Os Gallus domesticus Huang, cattle otter nose (" Quanzhou book on Chinese herbal medicine "), agnail grass (Guangzhou army " conventional Chinese herbal medicine handbook "), Penis et testis Tigris grass, sticky body grass, duck foot joint (" Fujian Chinese herbal medicine "), Herba lespedezae pilosae, scoop up nose grass (" practical Chinese herbal medicine "), strangle the herb that grass (Guangzhou air force " conventional Chinese herbal medicine handbook ") [source] is amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.[nature and flavor] toil, cold.[function cures mainly] heat clearing away, induces sweat, and diuretic, invigorates blood circulation.Cure cold heating, dysentery, malaria, laryngalgia, beriberi, gonorrhea.Edema, traumatic injury.[extracts] " Chinese medicine voluminous dictionary "

Herba Zebrinae Pendulae: [another name] floral leaf bamboo is picked up food with chopsticks, red lotus, Herba sagittariae pygmaeae is red, golden hair is careless, flexuose bittercress herb and seed, the purple back of the body Herba Commelinae, red bamboo mussel, Baidu powder.The herb of [source] Commelianaceae Phyllostachys congesta grass platymiscium Phyllostachys congesta grass Zebrinapendula Schnizl..The whole year can adopt, and cleans, using fresh herb or dry.[nature and flavor] are sweet, cool.[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood, diuresis.For pulmonary tuberculosis cough spitting of blood, laryngopharynx swelling and pain, acute conjunctivitis, bacillary dysentery, oedema due to nephritis, urinary tract infection, leucorrhea, panaris, venom.[extracts] " national Chinese herbal medicine compilation "

Folium Baeckeae: [another name] besom branch, Kochia scoparia, sheep Lei wood.[source] Myrtaceae Folium Baeckeae platymiscium Folium Baeckeae Baeckea frutescens L. is used as medicine with root, Herb and leaf.The whole year can adopt, and cleans, using fresh herb or dry.[nature and flavor] are pungent, bitter, puckery, cool.[function cures mainly] expelling wind and removing dampness, removing toxic substances diuresis, antalgesic-antipruritic.Root: for high heat of catching a cold, icterohepatitis, stomachache, enteritis, rheumatic arthritis, vitamin B1 deficiency, cystitis, dysuria.[extracts] " national Chinese herbal medicine compilation "

Caulis Cucumidis sativiv: [source] is the stem of cucurbitaceous plant Fructus Cucumidis sativi.June adopts.Dry in the shade or using fresh herb.[nature and flavor] are " Traditional Chinese Medicine in Sichuan will " 1.: " property is put down, lightly seasoned, nontoxic." [function cures mainly] diuretic, removing toxic substances.Control dysentery, gonorrhea, impetigo." Traditional Chinese Medicine in Sichuan will ": " diuretic, treating stranguria, relieving distension." [extracts] " Chinese medicine voluminous dictionary "

Folium Hyoscyami: [another name] small bell grass (" Chinese herbal medicine handbook is commonly used in Qinghai "), fiber crops property grass (" Hunan medicine will ").[source] is the blade of plant of Solanaceae hyoscyami, gathers, dry after the Beginning of summer.[nature and flavor] " sweet peaceful blue or green Chinese herbal medicine choosing in Shan ": " bitter, cold, very toxic." [function cures mainly] eases pain, spasmolytic.Treat for stomachache, toothache, cough and asthma caused by tracheitis." will planted by middle traditional Chinese medicines ": " be the analgesic of cystitis and gonorrhea, share with cathartic, upper intestinal colic can be prevented." [extracts] " Chinese medicine voluminous dictionary "

Herba Polycarpaeae Corymbosae: [another name] Caulis et folium pavettae hongkongensis grass (" Guangzhou flora "), arduous grass, starvation careless (" Quanzhou book on Chinese herbal medicine "), the wide Radix Pulsatillae, star color leather (Guangzhou air force " conventional Chinese herbal medicine handbook ").[source] is the pinkwort bulging herb followed closely in vain.Summer gathers.[nature and flavor] " Quanzhou book on Chinese herbal medicine ": " sweet, flat, nontoxic." [return through] " Quanzhou book on Chinese herbal medicine ": " enters the heart, liver, lung, all warps of stomach." [function cures mainly] heat-clearing and toxic substances removing, diuresis.Control dysentery, enteritis, gonorrhea difficulty and pain in micturition, swollen ulcer drug." Quanzhou book on Chinese herbal medicine ": " poison that relieves inflammation or internal heat is hot and suffocating, opens breast profit diaphragm.Control middle stagnation of QI knot, treating stranguria diuresis, lactogenesis, detumescence poison and all poisonous insect snakebites." [extracts] " Chinese medicine voluminous dictionary "

Herba abutili indici: [another name] ear rings grass, hemp, soil rice huller shield, stone grinder is young, the young grass of mill, mill shelves are careless.[source] Malvaceae abutilon plant Herba abutili indici Abutilon indicum (L.) G.Don, is used as medicine with herb or root.Summer, autumn gather, and clean and dry.[nature and flavor] are sweet, light, flat.[function cures mainly] wind and heat dispersing, QI invigorating is sensible, diuresis of eliminating the phlegm.For flu, heat of a specified duration is not moved back, mumps, tinnitus, deaf, pulmonary tuberculosis, dysuria.[extracts] " national Chinese herbal medicine compilation "

Folium Querci dentatae: [another name] is if Mongolian oak (Tang Materia Medica).[source] is the leaf of Fagaceae live oak.[nature and flavor] Tang Materia Medica: " sweet-bitter flavor is flat, nontoxic." [function cures mainly] controls haematemesis, epistaxis, dysentery, internal hemorrhoid with bleeding, gonorrhea." detailed outline ": " invigorate blood circulation, diuresis, except on face, Zha is red." " modern Practical Chinese medicinal ": " controls gonorrhea, dark coloured urine, expelling tenia again." [extracts] " Chinese medicine voluminous dictionary "

Rhizoma typhae: [another name] Pollen Typhae root (" galactopoiesis collection proved recipe "), Pu Radix Crotalariae szemoensis (" daily book on Chinese herbal medicine "), Pu root (" wild herbs spectrum "), rush bag grass roots (" Chinese herbal medicine is commonly used in Shanghai ").[source] for Typhaceae plant typha angustata or its belong to the rhizome with part tender stem of various plants together.Spring excavates.[nature and flavor] are sweet, cool.[function cures mainly] clearing away heat and cooling blood, inducing diuresis to remove edema.Control anemia of pregnant woman's consumptive fever, vaginal bleeding due to excessive movement of fetus, quench one's thirst, aphtha, hematodiarrhoea, gonorrhea, leucorrhea, edema, scrofula." Kaibao Bencao ": " control pouring drop, damp-edema." [extracts] " Chinese medicine voluminous dictionary "

Semen althaeae roseae: [source] is the seed of Malvaceae plant Althaea rosea (L.) Cavan..[nature and flavor] are sweet, cold.[function cures mainly] relieving stranguria by diuresis, laxation.Harness the river swollen, gonorrhea, constipation, skin ulcer scabies.[extracts] " Chinese medicine voluminous dictionary "

Herba potamogetonis distincti: [another name] Herba Potamogetonis Natantis, water stool, golden comb grass, Viola grypoceras A. Gray, setting-out grass [source] Potamogetonaceae Potamogeton plant Herba potamogetonis distincti Potamogeton franchetii A.Benn.et Baag., with all herbal medicine.Spring and autumn gathers, and dries.[nature and flavor] micro-hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, diuresis, removing food stagnancy.For acute conjunctivitis, jaundice, edema, leucorrhea, infantile malnutrition, ascariasis; Carbuncle furuncle and phyma poison is controlled in external.[extracts] " national Chinese herbal medicine compilation "

Lignum cercis chinensis: [source] is the woody part of leguminous plant cercis.[nature and flavor] " Kaibao Bencao ": " bitter in the mouth is flat, nontoxic." [function cures mainly] invigorates blood circulation, treating stranguria.Control dysmenorrhes, abdominal pain due to blood stasis, gonorrhea.[extracts] " Chinese medicine voluminous dictionary "

Spica Prunellae: [another name] wooden club grass, ferrum color grass, large headdress flower, summer withered head.[source] this product is the dry fruit ear of labiate Spica Prunellae Prunellavulgaris L..Gather when summer, fruit ear was brownish red, removing impurity, dries.[nature and flavor] are pungent, bitter, cold.[return through] returns liver, gallbladder meridian.[function cures mainly] relieves inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.[extracts] " Chinese Pharmacopoeia "

Herba Fimbristylis dichotomae: [source] medical material Ji Yuan: be the herb of sedge two qi Herba Fimbristylis dichotomae.[nature and flavor] are lightly seasoned; Cold in nature.[return through] kidney; Urinary bladder channel.[function cures mainly] clearing away heat and promoting diuresis; Removing toxic substances.Main dysuria; Damp and hot edema; Gonorrhea; Infantile carbuncle.[extracts] " China's book on Chinese herbal medicine "

Herba Meliloti Suaveolentis: [another name] Herba medicaginis falcatae, Pin Chuan bush clover, Fu bush clover (" Chinese main plant figure says pulse family "), Kochia scoparia (" Traditional Chinese Medicine in Sichuan will "), Herba boeae clarkeanae (" medicine investigation is planted in Shaanxi "), Ocimum basilicum L. var. pilosum, wild peanut, Caput Gallus domesticus flowers and plants (" Chinese herbal medicine is commonly used in Shanghai "), chicken lousewort (" Chinese herbal medicine is commonly used in Sichuan "), Herba Meliloti officinalis (" Jilin Chinese herbal medicine "), smelly Herba Medicaginis, relieve internal heat grass (" Shaanxi Chinese herbal medicine "), fragrant horse material (" discriminating of Heilongjiang Province Main Wild Medicinal plant and Chinese herbal medicine novel formulation "), in very stop in east (towards name).[source] is the herb of leguminous plant melilotus.Florescence harvesting herb, dries in the shade.[nature and flavor] work hard, cool.[function cures mainly] heat clearing away, removing toxic substances, removing dampness, parasite killing.Control summer-heat uncomfortable in chest, malaria, dysentery, gonorrhea, sores ulceration of skin." Traditional Chinese Medicine in Sichuan will ": " heat clearing away, removing toxic substances, parasite killing, diuresis.Control skin sore, urticaria, dysentery with red and white feces, gonorrhea." [extracts] " Chinese medicine voluminous dictionary "

Herba Oxalidis Strictae: [another name] crow acid.[source] is the tight oxalic herb of Oxalidaceae plant.The end of spring and the beginning of summer gathers, and dries.[nature and flavor] are bitter, cold, slightly poisonous.[function cures mainly] parasite killing, pain relieving, heat radiation, detumescence, blood stasis dispelling.Filaricide (erysipelas) initial stage is controlled in decoction, gonorrhea, traumatic injury; Smash to apply and control toxic swelling, burn, scabies.[extracts] " Chinese medicine voluminous dictionary "

Herba Malvae parviflorae: [another name] Xi (" elegant "), Radix Semiaquilegiae (" Bencao Tujing "), chessboard dish (" Zhiwu Mingshi Tukao "), acute mastitis medicine (" register planted by Guangxi medicine ").[source] is the stem and leaf of Malvaceae plant Herba Malvae parviflorae.Summer, autumn gather.[nature and flavor] Tang Materia Medica: " sweet, cold, nontoxic." [function cures mainly] controls gonorrhea, dysuria, acute mastitis, and skin ulcer swells.Tang Materia Medica: " main lower all stone five types of stranguria, only blacksnake poison." [extracts] " Chinese medicine voluminous dictionary "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Herba Solani Lyrati 30 ~ 40 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 25 parts, Herba Zebrinae Pendulae 15 ~ 25 parts, Folium Baeckeae 5 ~ 15 parts, Caulis Cucumidis sativiv 10 ~ 20 parts, Folium Hyoscyami 5 ~ 15 parts, Herba Polycarpaeae Corymbosae 5 ~ 15 parts, Herba abutili indici 30 ~ 40 parts, Folium Querci dentatae 10 ~ 20 parts of Rhizoma typhae 15 ~ 25 parts, Semen althaeae roseae 5 ~ 15 parts, Herba potamogetonis distincti 10 ~ 20 parts, Lignum cercis chinensis 10 ~ 20 parts, Spica Prunellae 15 ~ 25 parts, Herba Fimbristylis dichotomae 30 ~ 40 parts, Herba Meliloti Suaveolentis 5 ~ 15 parts, Herba Oxalidis Strictae 15 ~ 25 parts and Herba Malvae parviflorae 5 ~ 15 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Solani Lyrati 30 ~ 35 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Herba Zebrinae Pendulae 15 ~ 20 parts, Folium Baeckeae 5 ~ 10 parts, Caulis Cucumidis sativiv 10 ~ 15 parts, Folium Hyoscyami 5 ~ 10 parts, Herba Polycarpaeae Corymbosae 5 ~ 10 parts, Herba abutili indici 30 ~ 35 parts, Folium Querci dentatae 10 ~ 15 parts of ， Rhizoma typhae 15 ~ 20 parts, Semen althaeae roseae 5 ~ 10 parts, Herba potamogetonis distincti 10 ~ 15 parts, Lignum cercis chinensis 10 ~ 15 parts, Spica Prunellae 15 ~ 20 parts, Herba Fimbristylis dichotomae 30 ~ 35 parts, Herba Meliloti Suaveolentis 5 ~ 10 parts, Herba Oxalidis Strictae 15 ~ 20 parts and Herba Malvae parviflorae 5 ~ 10 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Solani Lyrati 33 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 16 parts, Herba Zebrinae Pendulae 19 parts, Folium Baeckeae 6 parts, Caulis Cucumidis sativiv 11 parts, Folium Hyoscyami 8 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 32 parts, Folium Querci dentatae 13 parts of Rhizoma typhae 18 parts, Semen althaeae roseae 7 parts, Herba potamogetonis distincti 11 parts, Lignum cercis chinensis 14 parts, Spica Prunellae 20 parts, Herba Fimbristylis dichotomae 32 parts, Herba Meliloti Suaveolentis 5 parts, Herba Oxalidis Strictae 16 parts and Herba Malvae parviflorae 6 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Herba Solani Lyrati 31 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Herba Zebrinae Pendulae 15 parts, Folium Baeckeae 8 parts, Caulis Cucumidis sativiv 15 parts, Folium Hyoscyami 5 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 35 parts, Folium Querci dentatae 10 parts of Rhizoma typhae 16 parts, Semen althaeae roseae 10 parts, Herba potamogetonis distincti 13 parts, Lignum cercis chinensis 10 parts, Spica Prunellae 15 parts, Herba Fimbristylis dichotomae 35 parts, Herba Meliloti Suaveolentis 10 parts, Herba Oxalidis Strictae 20 parts and Herba Malvae parviflorae 9 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1 powder

Get Herba Solani Lyrati 330g, Radix achyranthis asperae (Herba Achyranthis Asperae) 160g, Herba Zebrinae Pendulae 190g, Folium Baeckeae 60g, Caulis Cucumidis sativiv 110g, Folium Hyoscyami 80g, Herba Polycarpaeae Corymbosae 70g, Herba abutili indici 320g, Folium Querci dentatae 130g Rhizoma typhae 180g, Semen althaeae roseae 70g, Herba potamogetonis distincti 110g, Lignum cercis chinensis 140g, Spica Prunellae 200g, Herba Fimbristylis dichotomae 320g, Herba Meliloti Suaveolentis 50g, Herba Oxalidis Strictae 160g and Herba Malvae parviflorae 60g.

Prepare according to the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 8 hours, with slow fire boiling, decocting time is 4 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters acquisition second filtrate, and the quality of the water added is 3 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 100 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 20%, and by the material pouch after mixing or packing box subpackage, every 10 grams is one bag of subpackage.

Embodiment 2 decoction

Get Herba Solani Lyrati 31g, Radix achyranthis asperae (Herba Achyranthis Asperae) 18g, Herba Zebrinae Pendulae 15g, Folium Baeckeae 8g, Caulis Cucumidis sativiv 15g, Folium Hyoscyami 5g, Herba Polycarpaeae Corymbosae 7g, Herba abutili indici 35g, Folium Querci dentatae 10g ， Rhizoma typhae 16g, Semen althaeae roseae 10g, Herba potamogetonis distincti 13g, Lignum cercis chinensis 10g, Spica Prunellae 15g, Herba Fimbristylis dichotomae 35g, Herba Meliloti Suaveolentis 10g, Herba Oxalidis Strictae 20g and Herba Malvae parviflorae 9g.

Prepare according to the following steps:

When the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 5 hours;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 5 hours;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese powder medicine prepared by embodiments of the invention 1, (concentration is 8.34g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 41.7 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage powder LD50>41.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 83.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 583 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 powder of the present invention presses 13.55,22.85 and 42.23g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 150 routine cases are my Out-patient Department patient of in November, 2010 ~ 2014 year July.Patient is divided into treatment group and matched group at random, wherein treatment group 75 people, male 18 people, women 57 people, 18 ~ 66 years old age; Matched group 75 people, male 16 people, women 59 people, 19 ~ 65 years old age.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria: cardinal symptom is frequent micturition, urgent micturition, dysurea, similar urinary incontinence time serious, the discomforts such as companion's lower abdominal pain, urine routine: leukocyte (+), erythrocyte (+), urine positive bacterial culture.

Syndrome Differentiation of Traditional Chinese Medicine standard: insufficiency of spleen-qi type: urine does not draw for separating, or amount is brisk and neat less and not, hematuria, limbs fatigue and weakness, wasting, and diarrhea with loose stool, indigestion and loss of appetite dull, breathe hard Yan Wei etc., pale tongue, and tongue is white, and deep pulse is unable.

Get rid of object: (1) makes a definite diagnosis chronic cystitis patient; (2) with other serious conditions person.Therapeutic Method:

Matched group: oral hydrochloride Ciprofloxacin Tablets 0.5g/ time, every day 2 times.7 days courses for the treatment of.

Treatment group: oral each 2 bags of Chinese medicine embodiment 1 powder of the present invention, every day 3 times.7 days courses for the treatment of.

Curative effect judging standard: clinical cure: Clinical symptom and sign disappears, routine urianlysis recovers normal for 2 times, urine Bacterial Negative, and is feminine gender in the 2nd, 6 week check urine thin bacterium.Effective: clinical symptom disappearance or substantially disappear, routine urinalysis is normal or close to normal, urine Bacterial Negative.Take a turn for the better: clinical symptom relief, routine urinalysis significantly improves, and urine antibacterial culturing is even the positive.Invalid: clinical symptoms and routine urianlysis obviously do not improve, urine bacterioscopy is still positive, or urine thin bacterium is still positive when check in the 2nd, 6 week, and is same strain.

Therapeutic outcome: treat 1 course for the treatment of and through the 2nd, 6 week check after, statistical result sees the following form.

Group	n	Clinical cure	Effective	Take a turn for the better	Invalid	Effectively total
							Treatment group	75	61	8	5	1	74(98.7％)
Matched group	75	38	12	16	9	66(88％)

Untoward reaction: treatment group occurs untoward reaction without patient; There is abdominal discomfort or pain in matched group 3 example, there is diarrhoea in 2 examples, there is n or V in 5 examples, 2 examples occur dizzy, and 1 example occurs drowsiness, and skin pruritus appears in 2 examples, within after drug withdrawal 2-5 days, disappear, the untoward reaction rate for the treatment of group is 0%, and the untoward reaction rate of matched group is 20%, and treatment group untoward reaction rate is starkly lower than matched group.

Concrete case: Zhao, female, 49 years old.Because of frequent micturition, urgent micturition, dysurea is gone to a doctor, and urine does not draw for separating, or amount is brisk and neat less and not, limbs fatigue and weakness, wasting, diarrhea with loose stool, and indigestion and loss of appetite dull, breathe hard Yan Wei, pale tongue, and tongue is white, and deep pulse is unable.Urine routine: leukocyte (+), erythrocyte (+), urine bacterioscopy is positive.Be diagnosed as insufficiency of spleen-qi type acute cystitis.Give each 2 bags of Chinese medicine embodiment 1 powder of the present invention, every day 3 times, treat 1 the course for the treatment of clinical cure.2nd, within 6 weeks, check urine thin bacterium is feminine gender.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for insufficiency of spleen-qi type acute cystitis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Herba Solani Lyrati, Radix achyranthis asperae (Herba Achyranthis Asperae), Herba Zebrinae Pendulae, Folium Baeckeae, Caulis Cucumidis sativiv, Folium Hyoscyami, Herba Polycarpaeae Corymbosae, Herba abutili indici, Folium Querci dentatae ， Rhizoma typhae, Semen althaeae roseae, Herba potamogetonis distincti, Lignum cercis chinensis, Spica Prunellae, Herba Fimbristylis dichotomae, Herba Meliloti Suaveolentis, Herba Oxalidis Strictae and Herba Malvae parviflorae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Solani Lyrati 30 ~ 40 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 25 parts, Herba Zebrinae Pendulae 15 ~ 25 parts, Folium Baeckeae 5 ~ 15 parts, Caulis Cucumidis sativiv 10 ~ 20 parts, Folium Hyoscyami 5 ~ 15 parts, Herba Polycarpaeae Corymbosae 5 ~ 15 parts, Herba abutili indici 30 ~ 40 parts, Folium Querci dentatae 10 ~ 20 parts of ， Rhizoma typhae 15 ~ 25 parts, Semen althaeae roseae 5 ~ 15 parts, Herba potamogetonis distincti 10 ~ 20 parts, Lignum cercis chinensis 10 ~ 20 parts, Spica Prunellae 15 ~ 25 parts, Herba Fimbristylis dichotomae 30 ~ 40 parts, Herba Meliloti Suaveolentis 5 ~ 15 parts, Herba Oxalidis Strictae 15 ~ 25 parts and Herba Malvae parviflorae 5 ~ 15 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Solani Lyrati 30 ~ 35 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 ~ 20 parts, Herba Zebrinae Pendulae 15 ~ 20 parts, Folium Baeckeae 5 ~ 10 parts, Caulis Cucumidis sativiv 10 ~ 15 parts, Folium Hyoscyami 5 ~ 10 parts, Herba Polycarpaeae Corymbosae 5 ~ 10 parts, Herba abutili indici 30 ~ 35 parts, Folium Querci dentatae 10 ~ 15 parts, Rhizoma typhae 15 ~ 20 parts, Semen althaeae roseae 5 ~ 10 parts, Herba potamogetonis distincti 10 ~ 15 parts, Lignum cercis chinensis 10 ~ 15 parts, Spica Prunellae 15 ~ 20 parts, Herba Fimbristylis dichotomae 30 ~ 35 parts, Herba Meliloti Suaveolentis 5 ~ 10 parts, Herba Oxalidis Strictae 15 ~ 20 parts and Herba Malvae parviflorae 5 ~ 10 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Solani Lyrati 33 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 16 parts, Herba Zebrinae Pendulae 19 parts, Folium Baeckeae 6 parts, Caulis Cucumidis sativiv 11 parts, Folium Hyoscyami 8 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 32 parts, Folium Querci dentatae 13 parts of ， Rhizoma typhae 18 parts, Semen althaeae roseae 7 parts, Herba potamogetonis distincti 11 parts, Lignum cercis chinensis 14 parts, Spica Prunellae 20 parts, Herba Fimbristylis dichotomae 32 parts, Herba Meliloti Suaveolentis 5 parts, Herba Oxalidis Strictae 16 parts and Herba Malvae parviflorae 6 parts.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Herba Solani Lyrati 31 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 18 parts, Herba Zebrinae Pendulae 15 parts, Folium Baeckeae 8 parts, Caulis Cucumidis sativiv 15 parts, Folium Hyoscyami 5 parts, Herba Polycarpaeae Corymbosae 7 parts, Herba abutili indici 35 parts, Folium Querci dentatae 10 parts of ， Rhizoma typhae 16 parts, Semen althaeae roseae 10 parts, Herba potamogetonis distincti 13 parts, Lignum cercis chinensis 10 parts, Spica Prunellae 15 parts, Herba Fimbristylis dichotomae 35 parts, Herba Meliloti Suaveolentis 10 parts, Herba Oxalidis Strictae 20 parts and Herba Malvae parviflorae 9 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step, is mixed in proportion described raw medicinal material, is ground into powder;

Second step, the first step is obtained powder and add in cold water and soak 6 hours ~ 12 hours, with slow fire boiling, decocting time is 3 hours ~ 5 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that the first step obtains;

3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours ~ 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 ~ 4 times of the powder quality that second step obtains;

4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered, and granularity is 80 ~ 120 orders;

5th step, in the powder that described 4th step obtains, add starch, the percentage by weight of described starch in described powder is 15% ~ 30%, and by the material pouch after mixing or packing box subpackage, every 5 ~ 10 grams is one bag or a box subpackage.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:

Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;

Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;

Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.