CN104958420A - Traditional Chinese medicine for treating phlegm turbidity type migraine and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating phlegm turbidity migraine and a preparation method thereof. The traditional Chinese medicine comprises Thalictrum omeiense herb, lateripening Bartsia herb, leatherleaf Mahonia fruit, common Souliea rhizome, intermediate peashrub herb, feather cockscomb stem leaf or root, slender root of common monkshood, Sophora moorcroftiana seed, Dysosma difformis root or rhizome, Selaginella uncinata herb, wax gourd vine, Lingnan Artocarpus fruit, root of small Polemonium, herb of creeping sage, winter crookneck squash, flower of Chinese Anisopappus, Chloranthus officinalis herb and Euaraliopsis ferruginea root or leaf. The traditional Chinese medicine has definite therapeutic effect on the phlegm turbidity type migraine and has small toxic and side effect.

Description

One treats migrainous Chinese medicine of the turbid upper illiteracy type of expectorant and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to one and treating migrainous Chinese medicine of the turbid upper illiteracy type of expectorant and preparation method thereof.

Background technology

Migraine is a kind of common chronic forms vascular illness, and a lot of disease is in child and adolescence, and the young and middle-aged phase reaches onset peak, and women is common, and men and women's Proportion of patients is about 1: 2 ~ 3, and in crowd, prevalence is 5% ~ 10%, often has genetic background.The periodical attack disease of migraine Shi Yileiyou family morbidity tendency.Show as paroxysmal inclined side pulsatile headache, companion's Nausea and vomiting and photophobia, fall ill again through one section of after date of having a rest.Headache relief in peace and quiet, dark surrounds or after sleep.Can with neural, mental function disorder before generation of having a headache or when showing effect.

Migraine (migraine) is clinical modal primary headache type; clinical with ictal middle severe, sample of beating headache for main manifestations; headache mostly is inclined side; general lasting 4 ~ 72 hours; can with Nausea and vomiting; light, Sound stimulat or daily routines all can increase the weight of headache, and quiet environment, rest can alleviate headache.Frequent Migraine outbreak will affect the life and work of patient, be exactly the most directly affect sleep, because do not have enough sleep, daytime, work was also greatly affected just out of spirits.And have some patients to be usually once the outbreak that works, extremely delay thing.Meanwhile, people suffers from headaches disease for a long time, and personality changes, and often disposition becomes irascible.Again because obstinate, life is subject to significant impact, and weak in mind, lose confidence, the time has been grown and will have a negative impact to the cardiovascular and cerebrovascular vessel of people, cerebral thrombosis after Headache attacks clinically, hypertension, and cerebral hemorrhage is clinical also more common.

Western medical treatment migraine generally adopts the method such as anti-inflammatory and antalgic and calcium channel blocking, but is difficult to clinically obtain satisfactory effect.

Migraine belongs to Chinese medicine " migraine " category.Head is " confluence of all yang-channels ", " mansion of clear sun ", and it occupies, and easily by ailment said due to cold or exposure is attacked, this is " on top, mountain peak, only wind can cause " event.If attacked for ailment said due to cold or exposure outer, interior be seven emotions, diet, and overstrain hindered, and covers the clear sun of resistance, retardance venation, then QI-blood circulation is not freely, the resistance of brain BI-syndrome involved the blood vessels, and general rule is not have a headache.

Summary of the invention

Technical problem to be solved by this invention is, provides one to treat migrainous Chinese medicine of the turbid upper illiteracy type of expectorant and preparation method thereof, and Chinese medicine of the present invention has definite curative effect to the turbid upper illiteracy type migraine of expectorant, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides one and treat the migrainous Chinese medicine of the turbid upper illiteracy type of expectorant, its raw medicinal material comprises: Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae, Herba Caraganae intermediae, Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis ， Radix Polemonii Liniflori, province of the Yuan Dynasty grass, gold melon, Flos Anisopappi chinensis, joint joint tea regulating YIN and YANG maple.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 5 ~ 10 parts, Herba Odontitis Serotinae 10 ~ 20 parts, Fructus Mahoniae 10 ~ 15 parts, Rhizoma soulieae vaginatae 5 ~ 10 parts, Herba Caraganae intermediae 15 ~ 20 parts, Herba Celosiae argenteae 10 ~ 15 parts, Radix Aconiti 20 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 15 ~ 20 parts, burden 7 10 ~ 25 parts, Herba Selaginellae Uncinatae 5 ~ 15 parts, Caulis Benincasae 10 ~ 20 parts, Fructus artocarpi lingnanensis 15 ~ 25 parts of Radix Polemonii Liniflori 5 ~ 15 parts, province of the Yuan Dynasty grass 15 ~ 25 parts, 20 ~ 30 parts, golden melon, Flos Anisopappi chinensis 10 ~ 20 parts, 15 ~ 25 parts, joint joint tea 20 ~ 35 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 8 ~ 10 parts, Herba Odontitis Serotinae 15 ~ 20 parts, Fructus Mahoniae 12 ~ 15 parts, Rhizoma soulieae vaginatae 7 ~ 10 parts, Herba Caraganae intermediae 15 ~ 18 parts, Herba Celosiae argenteae 12 ~ 15 parts, Radix Aconiti 25 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 ~ 20 parts, burden 7 15 ~ 25 parts, Herba Selaginellae Uncinatae 10 ~ 15 parts, Caulis Benincasae 15 ~ 20 parts, Fructus artocarpi lingnanensis 20 ~ 25 parts of Radix Polemonii Liniflori 10 ~ 15 parts, province of the Yuan Dynasty grass 18 ~ 25 parts, 25 ~ 30 parts, golden melon, Flos Anisopappi chinensis 15 ~ 20 parts, 20 ~ 25 parts, joint joint tea 25 ~ 35 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 8 parts, Herba Odontitis Serotinae 16 parts, Fructus Mahoniae 12 parts, Rhizoma soulieae vaginatae 7 parts, Herba Caraganae intermediae 15 parts, Herba Celosiae argenteae 15 parts, Radix Aconiti 26 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 parts, burden 7 20 parts, Herba Selaginellae Uncinatae 11 parts, Caulis Benincasae 16 parts, Fructus artocarpi lingnanensis 21 parts of Radix Polemonii Liniflori 12 parts, province of the Yuan Dynasty grass 20 parts, 25 parts, golden melon, Flos Anisopappi chinensis 16 parts, 21 parts, joint joint tea 28 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is most preferably as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 10 parts, Herba Odontitis Serotinae 20 parts, Fructus Mahoniae 15 parts, Rhizoma soulieae vaginatae 10 parts, Herba Caraganae intermediae 18 parts, Herba Celosiae argenteae 12 parts, Radix Aconiti 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 20 parts, burden 7 25 parts, Herba Selaginellae Uncinatae 15 parts, Caulis Benincasae 20 parts, Fructus artocarpi lingnanensis 25 parts of Radix Polemonii Liniflori 15 parts, province of the Yuan Dynasty grass 25 parts, 30 parts, golden melon, Flos Anisopappi chinensis 20 parts, 25 parts, joint joint tea 35 parts of regulating YIN and YANG maples.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is for during containing tablet, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis is with Radix Polemonii Liniflori mixes in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae and Fructus artocarpi lingnanensis mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1.5 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 4 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, static 12 ~ 18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.0g/mL ~ 1.5g/mL.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to the turbid upper illiteracy type migraine of expectorant, and toxic and side effects is little.

Detailed description of the invention

Embodiments provide one and treat the migrainous Chinese medicine of the turbid upper illiteracy type of expectorant, its raw medicinal material comprises: Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae, Herba Caraganae intermediae, Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis ， Radix Polemonii Liniflori, province of the Yuan Dynasty grass, gold melon, Flos Anisopappi chinensis, joint joint tea regulating YIN and YANG maple.

In above-mentioned Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Thalictrum omeiense W. T. Wang et S. H. Wang: [another name] Rhizoma Seu Herba Pteridis Dactylinae.[source] Ranunculaceae thalictrum spp high eyebrow Thalictrum aquilegifolium L. var. sibiricum Regel Thalictrum omeiense W.T.Wang et S.H.Wang, with all herbal medicine.Autumn gathers herb, dries.[nature and flavor] are bitter, puckery, cold.[function cures mainly] heat clearing away, dampness, dysentery relieving.For jaundice due to damp-heat, stomachache dysentery, malaria cold and heat, conjunctival congestion and swelling pain.[extracts] " national Chinese herbal medicine compilation "

Herba Odontitis Serotinae: [another name] Herba Odontitis serotinae.[source] Scrophulariaceae Herba Odontitis Serotinae platymiscium Herba Odontitis Serotinae Odontitesserotina (Lam.) Dum., with ground all herbal medicine.Gather when Xia Qiu is bloomed, dry in the shade.[nature and flavor] are bitter, cool.Slightly poisonous.[function cures mainly] heat clearing and damp drying, cooling blood and relieving pain.For hot infectious disease, liver and gall stagnant heat, blood stasis is had a pain.[extracts] " national Chinese herbal medicine compilation "

Fructus Mahoniae: [source] medical material Ji Yuan: be the fruit of Berberidaceae plant broad-leaved ten large merit Mahonia bealei (Fort.) Carr. mahonia fortuneiFedde Mahonia fortunei (Lindl.) fedde etc.[nature and flavor] are bitter; Cool.[return through] spleen; Kidney; Urinary bladder channel.[function cures mainly] clearind deficient heat; The kidney invigorating; Dampness.Main osteopyrexia and fever; Soreness of the waist and knees; Dizziness and tinnitus; Damp-heat diarrhea; Leukorrhagia; Stranguria with turbid discharge.[extracts] " China's book on Chinese herbal medicine "

Rhizoma soulieae vaginatae: [another name] Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), too white Rhizoma Coptidis (" Shaanxi Chinese herbal medicine ").Rhizome, herb that [source] is ranunculaceae plant Souliea vaginata.Gather after autumn.[nature and flavor] " Shaanxi Chinese herbal medicine ": " bitter, cool." [function cures mainly] " Shaanxi Chinese herbal medicine ": " pathogenic fire purging dampness, clear away heart-fire relieving restlessness, anti-inflammation, stomach invigorating.Control pharyngitis, conjunctivitis, stomatitis, osteopyrexia and fever, nervous cardiopalmus, dysphoria, bacillary dysentery, enteritis, carbuncle pyogenic infections from tumour or sore."。[extracts] " Chinese medicine voluminous dictionary "

Herba Caraganae intermediae: [source] medical material Ji Yuan: be the seed of leguminous plant Caragana intermedia.[nature and flavor] are bitter; Flat.[return through] lung meridian.[function cures mainly] dampness is detoxified, killing parasites for relieving itching.Main impetigo, neurodermatitis, psoriasis.[extracts] " China's book on Chinese herbal medicine "

Herba Celosiae argenteae: [another name] careless Artemisia, luxuriant Artemisia (" herbal classic "), the Kunlun grass (Tang Materia Medica), pheasant hat, cockscomb Herba Amaranthi tricoloris (" detailed outline "), wolf tail fruit, Meristotheca papulosa (Mont) J. Ag, common chicken hat (" medicine will is planted in Jiangsu "), Herba Urariae Lagopodioidis, refer to sky pen (" Nanning City's medicine will "), cow's tail flower (" Shandong Chinese medicine "), dog tail Flos Celosiae Cristatae (" east, Fujian book on Chinese herbal medicine ").The stem and leaf that [source] is amaranthaceous plant Herba Celosiae argenteae and root.[nature and flavor] are " herbal classic " 1.: " bitter in the mouth is slightly cold." heat clearing away of [function cures mainly] dampness, parasite killing, hemostasis.Control wind scabies itching over the body, skin ulcer scabies, hemorrhoid, incised wound is hemorrhage.[extracts] " Chinese medicine voluminous dictionary "

Radix Aconiti: [another name] white curtain (" herbal classic ").Long and the thin person of the shape that [source] is Radix Aconiti Lateralis Preparata or Radix Aconiti Kusnezoffii.[nature and flavor] are pungent, heat, poisonous.[function cures mainly] dispels the wind, cold expelling, dampness, benefiting the fire of the gate of life to invigorate YANG.Control anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, trusted subordinate's cold type of pain, mass beside the umbilicus lump in the abdomen.[extracts] " Chinese medicine voluminous dictionary "

Sophora moocroftiana(Wall．) Benth. Ex Bak.: [another name] Ji watt [Tibetan name].[source] pulse family Sophora moocroftiana(Wall．) Benth. Ex Bak. Sophoramoorcroftiana (Wall.) Benth.ex Baker, with fruit medicine.[nature and flavor] are bitter, cold.[function cures mainly] eliminating inflammation and expelling toxin.Control jaundice due to damp-heat, the diseases such as diphtheria.[extracts] " national Chinese herbal medicine compilation "

Burden seven: [another name] little Radix et Rhizoma Dysosmatis, half bowl of water, Schisandra propinqua (Wall.) Baill. Var. intermedia A. Smith.[source] Berberidaceae burden seven Dysosma difformis (Hemsl.etWils.) T.H.Wang, is used as medicine with root stock and root.[function cures mainly] loose wind eliminates the phlegm, removing toxic substances.[extracts] " national Chinese herbal medicine compilation "

Herba Selaginellae Uncinatae: [another name] stands on one foot as the cock does grass (" Wang Anqing gather medicinal herbs will "), emerald green tail feather grass, short foot phoenix hair (" Wang Lianshi gather medicinal herbs book "), Aster ericoidus (" Guangdong will "). Shen Jinhua, crane tail feather grass, Herba Pteridis Multifidae, to spread its tail wind hair (" detailed outline is picked up any lost article from the road "), dragon must, sword cypress (" Zhiwu Mingshi Tukao "), blue Sabina procumbens (" botany voluminous dictionary "), green floss grass (" Guangzhou flora "), HUISHENGCAO, Herba Hylothelephii Verticillati (" Fujian traditional herbal medicine "), golden pheasant Herba Pteridis Multifidae, water bird pawl (" the south of Fujian Province traditional herbal medicine "), stretch foot grass, Herba Asplenii Incisi, rock duckweed (" Hunan medicine will "), silks and satins grass (" register planted by Guangxi medicine "), Herba Titanotrichi oldhamii, dragon's paw grass, Cold boiled chicken pawl (" Fujian Chinese herbal medicine ").[source] is the herb of Spikemoss plant CUIYUNCAO.[nature and flavor] are " Fujian traditional herbal medicine " 1.: " micro-hardship, cold." [function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances, repercussive, hemostasis.Harness the Yellow River subcutaneous ulcer, dysentery, edema, rheumatic arthralgia, cough is spitted blood, retropharyngeal abscess, anal fistula, knife injury, scalds.[extracts] " Chinese medicine voluminous dictionary "

Caulis Benincasae: [source] medical material Ji Yuan: be the rattan of cucurbitaceous plant Fructus Benincasae.[nature and flavor] bitter in the mouth; Cold in nature.[return through] returns lung; Liver Channel.[function cures mainly] removing heat from the lung and dissipating phlegm; Dredge the meridian passage.Main lung-heat expectoration; Articular instability; Proctoptosis; Skin ulcer scabies.[extracts] " China's book on Chinese herbal medicine "

Fructus artocarpi lingnanensis: [another name] Canis familiaris L. fruit (" south of the Five Ridges gather medicinal herbs record "), kermes public affairs (Guangzhou army " commonly using Chinese herbal medicine handbook ").[source] is the fruit of moraceae plants osmanthus wood.Autumn gathers, and section is dried.[nature and flavor] Guangzhou army " conventional Chinese herbal medicine handbook ": " acid, flat." [function cures mainly] promotes the production of body fluid hemostasis, and appetizing is reduced phlegm.Control heat thirsty, hemoptysis, spit blood, epistaxis, laryngalgia, inappetence.[extracts] " Chinese medicine voluminous dictionary "

Radix Polemonii Liniflori: [another name] electric light flower (" Inner Mongol Chinese herbal medicine "), lamp sound flower (illiteracy name).[source] is the rhizome of Radix Polemonii Liniflori section vegetable silk Hua Radix Polemonii Liniflori and root.Autumn gathers, and cleans earth, dries.[nature and flavor] " Inner Mongol Chinese herbal medicine ": " bitter, flat."。[function cures mainly] eliminates the phlegm, hemostasis, calm.Control acute and chronic bronchitis, gastric hemorrhage, hemoptysis, epistaxis, metrorrhagia, epilepsy is had a sleepless night, menorrhagia.[extracts] " Chinese medicine voluminous dictionary "

Province of the Yuan Dynasty grass: [another name] flammule grass, little lamp-stand, Salvia substolonifera Stib.[source] Lamiaceae Salvia platymiscium viticula Mus tail Salvia substolonifera Stib., with all herbal medicine.Xia Qiu gathers, and dries.[nature and flavor] micro-hardship, pungent, flat.[function cures mainly] clearing away heat-damp and promoting diuresis, antiasthmatic-antitussive, regulating menstruation, hemostasis.For rheumatism cough, abundant expectoration is panted, and spits blood, leucorrhea, frequent micturition, lumbago, menorrhagia.[extracts] " national Chinese herbal medicine compilation "

Gold melon: [another name] old Fructus Momordicae charantiae, field rodent melon, Radix Trichosanthis, Cortex Capparis Spinosae Radicis.[source] medical material Ji Yuan: be root or the herb of cucurbitaceous plant gold melon.[function cures mainly] promoting blood flow to regulate menstruation; Channels sootheing and network vessel quickening; To reduce phlegm the scrofula that disappears.Main menoxenia; Joint aches; Trick flaccidity contracts; Scrofula.[extracts] " China's book on Chinese herbal medicine "

Flos Anisopappi chinensis: [another name] golden aster, non-irrigated mountain chrysanthemum, Flos Inulae [Guangxi].[source] Compositae Flos Anisopappi chinensis Anisopappus chinensis (L.) Hook.etArn., is used as medicine with flower.[nature and flavor] are bitter, cool.[function cures mainly] removing heat-phlegm.Cure mainly headache due to common cold, chronic tracheitis.[extracts] " national Chinese herbal medicine compilation "

Joint joint tea: [another name] dapsone joint, Herba Pileae Scriptae.[source] Chloranthaceae Chloranthus plant Chloranthus elatior Chloranthus officinalis Blume, is used as medicine with Herb.The whole year can adopt, and chopping is dried.[nature and flavor] pungent, micro-hardship, temperature.[function cures mainly] dredge the meridian passage, hemostasis.For flu, renal calculus, uterine prolapse, puerperal hemorrhage, epilepsy, traumatic injury impairment caused by overstrain, rheumatic numbness, arthritis, migraine; Fracture is controlled in external.[extracts] " national Chinese herbal medicine compilation "

Negative and positive maple: [another name] Japanese maple, Sassafras tsumu Hemsl., duck male.[source] medical material Ji Yuan: be root or the branch and leaf of Araliaceae rust hair palm leaf tree.[nature and flavor] acrid in the mouth; Bitter; Warm in nature.[function cures mainly] expelling wind and removing dampness; Suitable blood relaxing muscles and tendons; Pain relieving.Main air pain of dampness syndrome; Paralysis; Traumatic injury; Migraine; Carbuncle pyogenic infections from tumour or sore.[extracts] " China's book on Chinese herbal medicine "

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 5 ~ 10 parts, Herba Odontitis Serotinae 10 ~ 20 parts, Fructus Mahoniae 10 ~ 15 parts, Rhizoma soulieae vaginatae 5 ~ 10 parts, Herba Caraganae intermediae 15 ~ 20 parts, Herba Celosiae argenteae 10 ~ 15 parts, Radix Aconiti 20 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 15 ~ 20 parts, burden 7 10 ~ 25 parts, Herba Selaginellae Uncinatae 5 ~ 15 parts, Caulis Benincasae 10 ~ 20 parts, Fructus artocarpi lingnanensis 15 ~ 25 parts of Radix Polemonii Liniflori 5 ~ 15 parts, province of the Yuan Dynasty grass 15 ~ 25 parts, 20 ~ 30 parts, golden melon, Flos Anisopappi chinensis 10 ~ 20 parts, 15 ~ 25 parts, joint joint tea 20 ~ 35 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Thalictrum omeiense W. T. Wang et S. H. Wang 8 ~ 10 parts, Herba Odontitis Serotinae 15 ~ 20 parts, Fructus Mahoniae 12 ~ 15 parts, Rhizoma soulieae vaginatae 7 ~ 10 parts, Herba Caraganae intermediae 15 ~ 18 parts, Herba Celosiae argenteae 12 ~ 15 parts, Radix Aconiti 25 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 ~ 20 parts, burden 7 15 ~ 25 parts, Herba Selaginellae Uncinatae 10 ~ 15 parts, Caulis Benincasae 15 ~ 20 parts, Fructus artocarpi lingnanensis 20 ~ 25 parts of Radix Polemonii Liniflori 10 ~ 15 parts, province of the Yuan Dynasty grass 18 ~ 25 parts, 25 ~ 30 parts, golden melon, Flos Anisopappi chinensis 15 ~ 20 parts, 20 ~ 25 parts, joint joint tea 25 ~ 35 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Thalictrum omeiense W. T. Wang et S. H. Wang 8 parts, Herba Odontitis Serotinae 16 parts, Fructus Mahoniae 12 parts, Rhizoma soulieae vaginatae 7 parts, Herba Caraganae intermediae 15 parts, Herba Celosiae argenteae 15 parts, Radix Aconiti 26 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 parts, burden 7 20 parts, Herba Selaginellae Uncinatae 11 parts, Caulis Benincasae 16 parts, Fructus artocarpi lingnanensis 21 parts of Radix Polemonii Liniflori 12 parts, province of the Yuan Dynasty grass 20 parts, 25 parts, golden melon, Flos Anisopappi chinensis 16 parts, 21 parts, joint joint tea 28 parts of regulating YIN and YANG maples.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Thalictrum omeiense W. T. Wang et S. H. Wang 10 parts, Herba Odontitis Serotinae 20 parts, Fructus Mahoniae 15 parts, Rhizoma soulieae vaginatae 10 parts, Herba Caraganae intermediae 18 parts, Herba Celosiae argenteae 12 parts, Radix Aconiti 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 20 parts, burden 7 25 parts, Herba Selaginellae Uncinatae 15 parts, Caulis Benincasae 20 parts, Fructus artocarpi lingnanensis 25 parts of Radix Polemonii Liniflori 15 parts, province of the Yuan Dynasty grass 25 parts, 30 parts, golden melon, Flos Anisopappi chinensis 20 parts, 25 parts, joint joint tea 35 parts of regulating YIN and YANG maples.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is for during containing tablet, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis is with Radix Polemonii Liniflori mixes in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is syrup, its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae and Fructus artocarpi lingnanensis mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1.5 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 4 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, static 12 ~ 18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.0g/mL ~ 1.5g/mL.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: containing tablet

Get Thalictrum omeiense W. T. Wang et S. H. Wang 80g, Herba Odontitis Serotinae 160g, Fructus Mahoniae 120g, Rhizoma soulieae vaginatae 70g, the sub-150g of Herba Caraganae intermediae, Herba Celosiae argenteae 150g, Radix Aconiti 260g, Sophora moocroftiana(Wall．) Benth. Ex Bak. 170g, burden seven 200g, Herba Selaginellae Uncinatae 110g, Caulis Benincasae 160g, Fructus artocarpi lingnanensis 210g Radix Polemonii Liniflori 120g, the province of the Yuan Dynasty grass 200g, golden melon 250g, Flos Anisopappi chinensis 160g, joint joint tea 280g regulating YIN and YANG maple 210g.

Prepare according to the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 95% of 6 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 4 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis is with Radix Polemonii Liniflori mixes in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 95% of 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 5 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 3 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 times, the microcrystalline Cellulose of 0.05 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

Embodiment 2: syrup

Get Thalictrum omeiense W. T. Wang et S. H. Wang 100g, Herba Odontitis Serotinae 200g, Fructus Mahoniae 150g, Rhizoma soulieae vaginatae 100g, the sub-180g of Herba Caraganae intermediae, Herba Celosiae argenteae 120g, Radix Aconiti 300g, Sophora moocroftiana(Wall．) Benth. Ex Bak. 200g, burden seven 250g, Herba Selaginellae Uncinatae 150g, Caulis Benincasae 200g, Fructus artocarpi lingnanensis 250g Radix Polemonii Liniflori 150g, the province of the Yuan Dynasty grass 250g, golden melon 300g, Flos Anisopappi chinensis 200g, joint joint tea 350g regulating YIN and YANG maple 250g.

Prepare according to the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae and Fructus artocarpi lingnanensis mix in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 90% of 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, heating decoction 1 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, adds the water dissolution relative to mixture quality 1.5 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 72 hours under 8 DEG C of conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, adds water appropriate, stirs, static 18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.5g/mL.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 30 ~ 40g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the Traditional Chinese medicine lozenge agent prepared by embodiments of the invention 1 is dissolved in water, (concentration is 8.08g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 40.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>40.4 crude drug/kg, every day, maximum dosage-feeding was 80.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.125g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 35g) oral administration gavage Chinese medicine of the present invention is 646 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 of the present invention presses 14.13,21.25 and 41.66g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight containing tablet to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 102 routine cases are my Out-patient Department patient of in June, 2011 ~ 2014 year February.Patient is divided into treatment group and matched group at random, wherein treatment group 51 people, male 22 people, women 29 people, 15 ~ 50 years old age, average 32.4 years old, the course of disease 6 months ~ 10 years, average 4.4 years, classic migraine 10 people, common migraine 41 people, seizure frequency: monthly 1 ~ 2 time 22 example, monthly 2 ~ 4 times 18 examples, monthly >4 time 11 example; Matched group 51 people, male 24 people, women 27 people, age 16 ~ 50 years old, average 32.7 years old, the course of disease 5 months ~ 10 years, average 4.1 years, classic migraine 12 people, common migraine 39 people, seizure frequency: monthly 1 ~ 2 time 23 example, monthly 2 ~ 4 times 19 examples, monthly >4 time 9 example.Two groups in age, sex, the course of disease, sick type, the aspects such as clinical manifestation are through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria:

Diagnostic criteria: be diagnosed as common migraine or classic migraine by Western medicine diagnose standard and case exclusion standard, is then diagnosed as the turbid upper illiteracy type of expectorant further by TCM syndrome diagnostic criteria.

Western medicine diagnose standard: with reference to the diagnostic criteria of International Headache association formulation in 2004, is divided into Migraine without aura (common migraine) and the typical tendency migraine of companion (classic migraine).

1. Migraine without aura (common migraine) diagnostic criteria: (1) meets at least 5 outbreaks of (2) ~ (4) feature.(2) Headache attacks (untreated or fail to respond to any medical treatment) continues 4 ~ 72 hours.(3) have at least following in 2 headache features: 1. Unilateral; 2. pulsation; 3. in or severe headache; 4. daily routines (as walking or go upstairs) can increase the weight of headache, or initiatively can avoid sort of activity during headache.(4) at least with following 1 in headache process: 1. feel sick and (or) vomiting; 2. photophobia and phonophobia.(5) can not owing to other diseases.

2. accompany typical tendency migraine (classic migraine) diagnostic criteria: (1) meets at least 2 outbreaks of (2) ~ (4) feature in Migraine without aura diagnostic criteria.(2) tendency have at least following in a kind of performance, but unable symptom of not moving: the 1. visual symptoms of completely reversibility, comprises positive performance's (as flash of light, bright spot or bright line) and (or) negative performance (as defect of visual field); 2. the paraesthesia of completely reversibility, comprises positive performance's (as prickling sensation) and (or) negative performance (as numbness); 3. the laloplegia of completely reversibility.(3) at least following 2 are met: 1. visual symptoms and (or) one-sided sensory symptoms in the same way; 2. process >=5 minute developed gradually of at least 1 premonitory symptom, and (or) different premonitory symptoms occurs in succession, process >=5 minute; 3. each premonitory symptom continues 5 ~ 60 minutes.(4) occur to occur headache in latter 60 minutes in premonitory symptom, (2) ~ (4) item met in Migraine without aura diagnostic criteria of having a headache simultaneously or in tendency.(5) can not owing to other diseases.

Case exclusion standard: abuse tranquilizer, Ergotamine preparation person, takes other medicines treatment simultaneously; Use migraine preventive medicine person; Age under-18s or more than 52 years old person, gestation and women breast-feeding their children, drug allergy person; Suffer from the organic disease persons such as the heart, brain, kidney, liver; Curative effect person cannot do not judged by regulation medication and insufficient funds.

TCM syndrome diagnostic criteria: the turbid upper illiteracy type of expectorant: migraine is partial to head side, in heavy and unconsciousness, chest distress, vomiting and nausea is indigestion and loss of appetite, saliva of spitting, white and greasy fur, stringy and rolling pulse.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 1 containing tablet every day 3 times, each 32 weeks was 1 course for the treatment of;

Matched group: oral nimodipine tablet, a 40mg, 3 times on the one.It within 2 weeks, was 1 course for the treatment of.And treatments period is stopped using, other treats migrainous medicine.

Curative effect judging standard: overall efficacy evaluation is with reference to " new Chinese medicine guideline of clinical investigations " relevant criterion: cure (clinical recovery): headache and simultaneous phenomenon disappear more than 6 months without recurrence.Effective: pain intensity alleviates 2 grades, and simultaneous phenomenon alleviates, or attack times or durante dolors reduce more than 2/3.Effective: pain intensity alleviates 1 grade, or outbreak interval extends or durante dolors shortens less than 2/3.Invalid: pain intensity alleviates less than 1 grade, or durante dolors shortens less than 1/3, or pain increases the weight of, duration extension.

Therapeutic outcome: see the following form.

Two groups of comparitive study after 2 courses for the treatment of treated by table 1:

Group	n	Cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	51	24	21	6	0	51(100％)
Matched group	51	11	22	12	6	45(88.2％)

A table 2 liang group patient adds up recovery from illness number stage by stage and recovery from illness ration statistics is as follows:

Group	Number of cases	Treat 2 weeks	Treat 3 weeks	Treat 4 weeks
					Matched group	24	5(9.80％)	17(33.33％)	24(47.06％)
Treatment group	11	1(1.96％)	5(9.80％)	11(21.57％)

According to the clinical statistics in above table, Chinese medicine provided by the invention has that instant effect, effective percentage are high, determined curative effect, safety are high, the advantage that has no side effect.

Concrete case: Zhang, male, 36 years old.Headache history has 4 years, and every monthly average occurs 3 ~ 4 times, and migraine is partial to right side of head, and in heavy and unconsciousness, chest distress, vomiting and nausea is indigestion and loss of appetite, saliva of spitting, white and greasy fur, stringy and rolling pulse.Be diagnosed as the turbid upper illiteracy type common migraine of expectorant.Take Chinese medicine embodiment of the present invention 1 containing tablet every day 3 times, each 3, treat and fully recover afterwards for 3 weeks, follow up a case by regular visits to and do not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the migrainous Chinese medicine of the turbid upper illiteracy type of expectorant, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae, Herba Caraganae intermediae, Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis ， Radix Polemonii Liniflori, province of the Yuan Dynasty grass, gold melon, Flos Anisopappi chinensis, joint joint tea regulating YIN and YANG maple.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 5 ~ 10 parts, Herba Odontitis Serotinae 10 ~ 20 parts, Fructus Mahoniae 10 ~ 15 parts, Rhizoma soulieae vaginatae 5 ~ 10 parts, Herba Caraganae intermediae 15 ~ 20 parts, Herba Celosiae argenteae 10 ~ 15 parts, Radix Aconiti 20 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 15 ~ 20 parts, burden 7 10 ~ 25 parts, Herba Selaginellae Uncinatae 5 ~ 15 parts, Caulis Benincasae 10 ~ 20 parts, Fructus artocarpi lingnanensis 15 ~ 25 parts of Radix Polemonii Liniflori 5 ~ 15 parts, province of the Yuan Dynasty grass 15 ~ 25 parts, 20 ~ 30 parts, golden melon, Flos Anisopappi chinensis 10 ~ 20 parts, 15 ~ 25 parts, joint joint tea 20 ~ 35 parts of regulating YIN and YANG maples.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 8 ~ 10 parts, Herba Odontitis Serotinae 15 ~ 20 parts, Fructus Mahoniae 12 ~ 15 parts, Rhizoma soulieae vaginatae 7 ~ 10 parts, Herba Caraganae intermediae 15 ~ 18 parts, Herba Celosiae argenteae 12 ~ 15 parts, Radix Aconiti 25 ~ 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 ~ 20 parts, burden 7 15 ~ 25 parts, Herba Selaginellae Uncinatae 10 ~ 15 parts, Caulis Benincasae 15 ~ 20 parts, Fructus artocarpi lingnanensis 20 ~ 25 parts, Radix Polemonii Liniflori 10 ~ 15 parts, province of the Yuan Dynasty grass 18 ~ 25 parts, gold 25 ~ 30 parts, melon, Flos Anisopappi chinensis 15 ~ 20 parts, 20 ~ 25 parts, joint joint tea 25 ~ 35 parts of regulating YIN and YANG maples.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 8 parts, Herba Odontitis Serotinae 16 parts, Fructus Mahoniae 12 parts, Rhizoma soulieae vaginatae 7 parts, Herba Caraganae intermediae 15 parts, Herba Celosiae argenteae 15 parts, Radix Aconiti 26 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 17 parts, burden 7 20 parts, Herba Selaginellae Uncinatae 11 parts, Caulis Benincasae 16 parts, Fructus artocarpi lingnanensis 21 parts of ， Radix Polemonii Liniflori 12 parts, province of the Yuan Dynasty grass 20 parts, gold 25 parts, melon, Flos Anisopappi chinensis 16 parts, 21 parts, joint joint tea 28 parts of regulating YIN and YANG maples.

5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Thalictrum omeiense W. T. Wang et S. H. Wang 10 parts, Herba Odontitis Serotinae 20 parts, Fructus Mahoniae 15 parts, Rhizoma soulieae vaginatae 10 parts, Herba Caraganae intermediae 18 parts, Herba Celosiae argenteae 12 parts, Radix Aconiti 30 parts, Sophora moocroftiana(Wall．) Benth. Ex Bak. 20 parts, burden 7 25 parts, Herba Selaginellae Uncinatae 15 parts, Caulis Benincasae 20 parts, Fructus artocarpi lingnanensis 25 parts of ， Radix Polemonii Liniflori 15 parts, province of the Yuan Dynasty grass 25 parts, gold 30 parts, melon, Flos Anisopappi chinensis 20 parts, 25 parts, joint joint tea 35 parts of regulating YIN and YANG maples.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis is with Radix Polemonii Liniflori mixes in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae and Fructus artocarpi lingnanensis mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1.5 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 4 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, static 12 ~ 18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.0g/mL ~ 1.5g/mL.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is for containing tablet, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae are in described ratio mixing, and with the dissolve with ethanol of the determining alcohol 90% ~ 95% of 4 ~ 6 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered; Merge twice filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8 ~ 1.2g crude drug/mL, the macroporous adsorptive resins eluting utilizing volume to be 5L twice, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae, Fructus artocarpi lingnanensis is with Radix Polemonii Liniflori mixes in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 3 ~ 5 times of the mixture quality obtained, extracted twice liquid merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 5 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 3 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge twice filtrate, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the carboxymethyl starch sodium of mixture quality 0.05 ~ 0.1 times, the microcrystalline Cellulose of 0.05 ~ 0.1 times relative to obtaining further, mixing, granulate, after drying, add the magnesium stearate relative to the mixture quality 0.01 ~ 0.05 times obtained, then with decompressor by granule tabletted, obtain containing tablet.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is syrup, and its preparation method comprises the following steps:

The first step, by Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Odontitis Serotinae, Fructus Mahoniae, Rhizoma soulieae vaginatae and Herba Caraganae intermediae mix in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filtered, obtained the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, by Herba Celosiae argenteae, Radix Aconiti, Sophora moocroftiana(Wall．) Benth. Ex Bak., burden seven, Herba Selaginellae Uncinatae, Caulis Benincasae and Fructus artocarpi lingnanensis mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1.5 ~ 2 times, by 40% sodium hydroxide solution adjust ph to 7.0, stir evenly, cold preservation 48 hours ~ 72 hours under 4 DEG C ~ 8 DEG C conditions, filter, filtrate adds the sucrose relative to the mixture quality 0.2 ~ 0.4 times obtained, and stirs and dissolves, adjust ph to 7.0, add water appropriate, stir, static 12 ~ 18 hours, filter, fill, sterilizing, obtain syrup, the crude drug concentration in described syrup is 1.0g/mL ~ 1.5g/mL.