CN106390034A - Traditional Chinese medicine compound preparation for curing 2-diabetes - Google Patents

Traditional Chinese medicine compound preparation for curing 2-diabetes Download PDF

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CN106390034A
CN106390034A CN201610998764.3A CN201610998764A CN106390034A CN 106390034 A CN106390034 A CN 106390034A CN 201610998764 A CN201610998764 A CN 201610998764A CN 106390034 A CN106390034 A CN 106390034A
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diabetes
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traditional chinese
preparation
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喇孝瑾
白素芬
田春雨
吴晨曦
程瑞婷
李继安
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North China University of Science and Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638—Ligustrum, e.g. Chinese privet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention relates to a traditional Chinese medicine compound preparation and a preparation method thereof, particularly relates to a traditional Chinese medicine compound preparation for curing 2-diabetes and a preparation method thereof, and belongs to the technical field of diabetes treatment in the traditional Chinese medicines. The technical scheme is as follows: the traditional Chinese medicine compound preparation is prepared from the following bulk drugs in parts by weight: 10-40 parts of turmeric, 10-40 parts of rheum officinale, 5-30 parts of rhizoma alismatis, 5-30 parts of fructus ligustri lucidi, 5-30 parts of grape seeds, and 5-30 parts of potentilla discolor. The traditional Chinese medicine compound preparation has the beneficial effects that: the medicine composition is reasonable; the traditional Chinese medicine compound preparation is safe to use, convenient to make and convenient to take, has remarkable curative effect and low side effects, is moderate in cost, rich in drug source and strong in operability; the materials are easy to get; the production process is advanced; and the traditional Chinese medicine compound preparation has the effects of reducing blood glucose, blood fat and blood viscosity of a 2-diabetes patient.

Description

A kind of treat compound Chinese medicinal preparation of diabetes B and preparation method thereof
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation and preparation method thereof, particularly treat diabetes B Chinese medicine compound prescription system Agent and preparation method thereof, belongs to TCM treatment of diabetes technical field.
Background technology
Diabetes be one group due to insulin secretion and（Or）Being characterized with chronic hyperglycemia caused by effect defect Metabolic disease.IDF（IDF）Announce sixth version in the United Nations's diabetes day on November 14th, 2013《State Border diabetes alliance diabetes map》Display, the whole world in 2013 there are about 3.82 hundred million adults and suffers from diabetes, and about 5,100,000 people are dead Die, just have 1 people to die from diabetes within averagely every 6 seconds, and expect 2035, this patient's number can rise to 5.92 hundred million, become For endangering the principal disease of human health, wherein, diabetes B（T2DM）Account for the 90%～95% of diabetes total number of persons.Under the pressure of tight High popular situation, countries in the world and international organization all give to pay high attention to the research of T2DM.
T2DM pathogenesis is extremely complex, and Western medicine is directed to different ill mechanism, and its action target spot is clearer, and effect is relatively By force.But, diabetes B patient is the entirety of organic connections, and many metabolism links of diabetic's body are deposited simultaneously In imbalance, act on merely a certain target drug and be difficult to play optimum therapeuticing effect, bring side effect also relatively obvious, primary Inefficacy, secondary failure problem are also more serious.Apply if we are in diabetes B early stage and there are integrally-regulated and Mutiple Targets Medicine certainly will improve therapeutic effect, symptom management development and the generation reducing complication.Therefore, research is integrally-regulated, many Target treatment and the low Chinese medicine of side effect have become a direction of diabetes B drug research.
The medicine for the treatment of diabetes is various in the market, and through retrieval, Chinese patent discloses following treatment diabetes to be had The report of the Chinese medicine preparation closing, now takes passages as follows：
L, Chinese patent<Application number>00108421<Denomination of invention>A kind of treat medicine of diabetes and preparation method thereof<Application People>The bright Liu Ping of Korea Spro ten thousand, branch of trend in Yangquan City Li Jia village First People's Hospital<Digest>The invention discloses a kind of new controlling Treat the medicine of diabetes, it is to give birth to the Radix Astragali, the dried rhizome of rehmannia, the red sage root, Rhizoma Dioscoreae, semen litchi, radix scrophulariae, rhizoma atractylodis, the fruit of Chinese wolfberry, dark plum, jade Rice palpus, the fruit of Chinese magnoliavine, root of Chinese trichosanthes, muskmelon pedicel, Chinese cassia tree, silkworm chrysalis, Ramulus euonymi, concha meretricis seu cylinae, the membrane of a chicken's gizzard, the root of kudzu vine, mulberry leaf, sealwort are raw material, According to the different characteristic of every taste Chinese medicine respectively through being lyophilized, dry, calcine, dedusting, pulverizing, prepare in proportion, then through curing, go out Powder is made after bacterium.
2nd, Chinese patent<Application number>99120424<Denomination of invention>A kind of treat medicine of diabetes and preparation method thereof< Applicant>Shao Yujun<Digest>The invention discloses a kind of treat Chinese patent drug of diabetes and preparation method thereof, this Chinese patent drug By pollen pini, the membrane of a chicken's gizzard, the Radix Astragali, radix pseudostellariae, golden cypress, corn stigma, the wind-weed, glutinous rehmannia, sealwort, the root bark of white mulberry, Chinese yam, semen litchi, pellet Spice in ginseng, Fructus Corni, rheum officinale and the fruit of Chinese magnoliavine 16 taste, is divided into four groups according to its active ingredient and physicochemical property, is respectively adopted water The technique decocted, be directly used as medicine after water decoction-alcohol sedimentation, alcohol extract and pulverizing, is prepared into capsule, treats diabetes.
The problem that prior art exists is least height, and medicine forms numerous and diverse, high cost, and composition is wayward, secondary work With many deficiencies such as larger.
Content of the invention
It is an object of the invention to provide a kind of treat compound Chinese medicinal preparation of diabetes B and preparation method thereof, medicine group Fang Heli, using safe, evident in efficacy, Small side effects, moderate cost, easy to make, medicine source is enriched, taking convenience, has fall The blood sugar of low diabetes B patient, blood fat, the effect of blood viscosity, solve the problems referred to above that background technology exists.
The object of the invention is achieved through the following technical solutions：
A kind of compound Chinese medicinal preparation treating diabetes B, this compound Chinese medicinal preparation is by the material medicine system of following weight parts Become：
10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, 5～30 parts of the fruit of glossy privet, 5～30 parts of grape pip, potentilla discolor 5 ～30 parts.
A kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, including following steps Suddenly：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract；
B. dry, pulverize into fine powder as active component；
C. the active component described in step b is made various formulations together with the carrier pharmaceutically accepting or excipient.
A kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, including following steps Suddenly：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract, as active component；
B. the active component described in step a is made various formulations together with the carrier pharmaceutically accepting or excipient.
We find in T2DM research for many years, this disease many middle ages sequela, and overweight people is in the majority, with overfeeding delicious food, Sitting is moved less and waited is inducement, and meets " vigour be unequal to its people of essence derived from food is fertile and not longevity " viewpoint and delicious food savoury must not change gas and raw phlegm Wet fat is turbid to stop up long-pending internal basic characteristics.Based on this it is considered that fat is turbid stops up the main pathology for diabetes B for long-pending, the strongly fragrant longization heat Mechanism, therefore draft with heat-clearing, let out the hypoglycemic compound as primary efficacy for the turbid, stagnation resolvation, full side by turmeric, rheum officinale, the fruit of glossy privet, turn over white Grass, rhizoma alismatis, grape pip composition, all medicines share makes the hot and suffocating of lung be discongested, can lead to the turbid pathogenic factor dropping clear key again, obtain in clinical practice Obtained preferable hypoglycemic effect.
In medical research, from traditional Chinese medical theory, through infrastest and with reference to clinical experience it is believed that diabete is normal See that the interpretation of the cause, onset and process of an illness is：Fat is turbid to stop up long-pending, strongly fragrant longization heat, and disease has blood stasis long concurrently（Hemostasis）.According to diabetic's clinical manifestation be many drinks, many Food, diuresis, become thin, the symptom such as spiritlessness and weakness, founded heat-clearing, let out turbid, stagnation resolvation therapeutic rules, in the guidance of this therapeutic rules Under prescription in addition.
Effect of material medicine and its effect in prescription are described below simply for the present invention every：
1st, turmeric：【Source】This product is the dry rhizome of zingiberaceous plant turmeric Curcuma longa L..【Nature and flavor】Pungent, bitter, temperature. 【Return through】Returns spleen, Liver Channel.【Chemical composition】Turmeric contains volatile oil 4.5%, 6%.Turmerone 58%, zingerene is contained in volatile oil 25%th, phellandrene 1%, 1, 8-Cineole 1%, sabinene 0.5%, borneol 0.5%, dehydroturmerone etc..Also contain curcumin 0.3%th, 1.1%, 4.8% and arabinose 1.1%, fructose 12%, glucose 28%, fat oil, starch, oxalates etc..【Work( Can cure mainly】Blood-breaking, inducing meastruation to relieve menalgia.Twinge for chest side of body, amenorrhoea, lump in the abdomen, rheumatism takes on arm pain, tumbling and swelling.
2nd, rheum officinale：【Source】This product is polygonum rheum palmatum Rheum palmatum L.Rheum tanguticum Maxim Rheum tanguticum Maxim. ex Balf.Or Rheum officinale Rheum officinale Baill.Root and rhizome is dried.【Property Taste】Hardship, trembles with fear.【Return through】Returns spleen, stomach, large intestine, liver, pericardium channel.【Chemical composition】The root shape of sorrel, rheum officinale and rheum tanguticum Tschircs Anthraquinone analog compound about 3% is contained, including free and bonding state Chrysophanol in stem and root（chrysophanol）, Rhein （rhein）, aloe-emodin（aloe-emodin）, rheum emodin（emodin）, parietin（Parietin, C22H22O10）、 Physcion（emodinmonomethyl ether）, under its main rushing down, composition is associativity Rhein anthrone-Sennosides A. B. C（sennoside A. B. C）Wherein Sennoside A（sennoside A）For principle active component.Additionally, still containing tan Matter about 5% and free gallic acid, cinnamic acid and its lipid etc..Leaf contains quercitrin, and only the leaf of sorrel is with hyperin （hyperoside）Content is most.【Indication】Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For real heat constipation, stagnant abdomen Bitterly, rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, and pharynx is swollen, abdominalgia with intestinal abscess, carbuncle swells furunculosis, blood stasis closed, traumatic injury, Control outward scald；UGB.Prepared RADIX ET RHIZOMA RHEI with wine is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.Swollen, the gingivitis for hot eyes pharynx.Prepared RADIX ET RHIZOMA RHEI Rush down and exert oneself to delay, purging intense heat and detonicating.For pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stop blooding.There is stasis of blood haemorrhage for blood-head.
3rd, rhizoma alismatis：【Source】This product is Notes On Alism At Aceae rhizoma alismatis Alisma orientalis（Sam.）Juzep. drying Stem tuber.【Nature and flavor】Sweet, tremble with fear.【Return through】Return kidney, bladder warp.【Chemical composition】【Chemical composition】Five kinds of triterpenes are separated in stem tuber Compound：Alisol A, alisol B, acetic acid alisol A ester, acetic acid alisol B ester and epialisol A；Separately contain volatile oil（Include chaff Aldehyde）, a small amount of alkaloid, asparagine, plant sterols, a kind of phytosterolin, aliphatic acid（Palmitic acid, stearic acid, oil Acid, linoleic acid）；Also resinous, protein and volume starch（23%）.【Indication】Diuresis, clearing away damp-heat.For urine not Profit, oedema turgor, oliguria of having loose bowels, phlegmatic vertigo, puckery pain of heat gonorrhea；High fat of blood.
4th, the fruit of glossy privet:【Source】This product is being dried to of Oleaceae plants glossy privet Ligustrum lucidum Ait. Ripe fruit.【Nature and flavor】Sweet, bitter, cold.【Return through】Return liver and kidney channel.【Chemical analysis】Containing nuzhenide（nuzhenide）, foreign olive Olive hardship glucoside（oleuropein）, oleanolic acid（oleanolic acid）, 4- hydroxyl-B- phenethyl-B-D- glycoside, birch Alcohol（betulin）Deng.【Indication】Nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh Secretly fail to understand.
5th, grape pip：【Source】This product is the seed of vitaceae grape Vitis vinifera L..【Nature and flavor】Sweet Micro- acid, mild-natured.【Return through】Enter liver, kidney, lung channel.【Chemical analysis】Polyphenols：Polyphenols (GPS) is contained in grape pip, main Catechin to be had and OPC class.Catechin compounds include catechin, epicatechin and its gallate, are Portugals Main single aggressiveness in grape seed, is also OPC oligomer and polymeric component unit.Grease type：Contain rich in grape pip Rich grease, accounts for the 12%～15% of its weight, contains substantial amounts of unrighted acid in oil, and wherein linoleic content exists Between 58%～78%.Volatile ingredient：A small amount of volatile ingredient is also contained, these materials belong to alcohol, phenol, terpene mostly in grape pip Class material, all has higher biologically active.Other compositions：In grape pip in addition to containing above-mentioned many kinds of substance, also contain thick Albumen, amino acid and vitamin A, E, D, K, P and various trace elements, such as calcium, zinc, iron, magnesium, copper, potassium, sodium, manganese, cobalt etc..【Work( Can cure mainly】There is the effect of filling liver kidney, replenishing qi and blood, nourishing the stomach to improve the production of body fluid, diuresis.
6th, potentilla discolor：【Source】Rose family potentilla plants potentilla discolor Potentilla discolor Bunge, with complete Grass or root are used as medicine.【Nature and flavor】Sweet, bitter, mild-natured.【Return through】Return liver, stomach, large intestine channel.【Chemical composition】1. piece contain condensed tannin And condensed tannin, and contain flavonoids.Herb contains fumaric acid（fumaric acid）, gallic acid（gallic acid）Former youngster Boheic acid（protocatechuic acid）, Quercetin（quercetin）, naringenin（naringenin）, Kaempferol （kaempferol）, isophthalic acid（m-phthalic acid）.2. fresh plant moisture content 62.39%, ascorbic acid 49.4 milli Gram %.Dry product moisture content 12.12%, protein 9.18%, fat 4.03%, crude fibre 21.89%, ash content 7.25%, P2O5-0.26%, Ca0-2.63%.【Indication】The effects such as have clearing heat and detoxicating, hemostasia and detumescence.Cure mainly dysentery, malaria, lung carbuncle, hemoptysis, haematemesis, under Blood, uterine bleeding, carbuncle swells, sore tinea, scrofula tuberculosis, are that Korean nationality, the Dong nationality, Naxi, the Yao nationality, Miao ethnic group, Tujia, Yi nationality, distributed over Yunnan, Sichuan and Guizhou etc. are national often Medication.Modern study shows, potentilla discolor has anti-inflammatory, antidiarrheal, immunosupress, the medicine such as antiviral, anti-oxidant, hypoglycemic, antitumor Reason acts on.
The combinations thereof medicine of the present invention can be used as Chinese traditional treatment diabete（Diabetes）Formula, its side solution and function Cure mainly：We in turmeric be monarch drug in a prescription, smell work hard, Great Cold is nontoxic, promoting the circulation of qi dissipate strongly fragrant, can enter the heart spleen two ward off epidemic disease, promoting blood circulationization through making contributions The stasis of blood, promoting the circulation of qi is soothing the liver, inducing meastruation to relieve menalgia, has anti-inflammatory, oxidation resistant activity；Rheum officinale is ministerial drug, bitter, and Great Cold is nontoxic, passes through up and down, Cover high sun very, non-this do not press down, bitter can purging intense heat, bitter can qi-restoratives, at one stroke and two it.Turmeric, rheum officinale, the turbid yin in fall the moon.One Rise a fall, inside and outside logical and, and pernicious influences of miscellaneous gas is paused and is disappeared.Potentilla discolor is clearing heat and detoxicating, fruit of glossy privet kidney tonifying enriching yin, nourishes the liver to improve visual acuity, peace The five internal organs, two medicines share heat-clearing and non-impairment of yin, and in solution, quenching one's thirst of heat is adjutant altogether.Rhizoma alismatis, grape pip strengthening the spleen and replenishing qi, moisturize, Li Shui Road, makes wet turbid phlegm and retained fluid go out from urine, is to make medicine altogether.All medicines share makes the hot and suffocating of lung be discongested, and can lead to the turbid pathogenic factor dropping clear key again.
The Chinese medicine preparation of the present invention is taken for diabetes B patient's decoct soup, is more suitable for modern pharmaceutical enterprise and extracts effectively to become Point, make any formulation in the pharmacies such as granule, capsule, oral liquid, because flavonoid glycoside is soluble in water, have very strong Hypoglycemic activity, alkaloid is soluble in water to have notable hypoglycemic activity；Polysaccharide is soluble in water, has stronger hypoglycemic work With glycoside is typically dissolved in water, and saponin(e is soluble in hot water, can promote insulin releasing, adjusts metabolism of blood glucose；Polypeptide is typically solvable Yu Shui.
The present invention has following features：1. the present invention, under guidance of traditional Chinese medicine theory, after animal experiments prove that, preferably goes up State Chinese medicine, in addition scientific compatibility, making, so that each medicine is cooperated, learn from other's strong points to offset one's weaknesses, synergy, all medicines share, sample and Control, heighten the effect of a treatment.2. the raw materials used small toxicity of the present invention, overcomes the toxic and side effect of other hypoglycemic medicines particularly Western medicine, and The shortcoming of the infringement to liver kidney after its Long-Time Service Western medicine.The use of product of the present invention is safe by daily dose and the course for the treatment of.This product Product are compared with melbine, and its blood sugar reducing function is suitable with melbine effect, do not have toxic and side effect compared with Western medicine.3. warp Zoopery and clinical verification product of the present invention can make diabetes B patient's fasting blood-glucose and 2 hours blood glucoses reduction after the meal, and Hold time longer, the person's cholesterol that simultaneously also makes high fat of blood and triglycerides reduce, evident in efficacy.4. scientific formula, raw material is easy , generation technique is advanced, simple and easy to do, workable, moderate product price, suitable preparation of industrialization.5. in preparation process According to the effective ingredient of each Chinese medicine, property and formulation requirements, using water extraction, physical sterilization method, thus product active ingredient Content is high, stable, is unlikely to deteriorate, is conducive to preserving for a long time.
Beneficial effect of the present invention：Medicament composing prescription is reasonable, using safe, evident in efficacy, Small side effects, moderate cost, making Convenient, medicine source is enriched, taking convenience, and raw material is easy to get, and generation technique is advanced, workable.
Specific embodiment
With reference to embodiment, the invention will be further described.
A kind of compound Chinese medicinal preparation treating diabetes B, this compound Chinese medicinal preparation is by the bulk drug of following weight parts Thing is made：
10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, 5～30 parts of the fruit of glossy privet, 5～30 parts of grape pip, potentilla discolor 5 ～30 parts.
A kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, including following steps Suddenly：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract；
B. dry, pulverize into fine powder as active component；
C. the active component described in step b is made various formulations together with the carrier pharmaceutically accepting or excipient.
A kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, including following steps Suddenly：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract, as active component；
B. the active component described in step a is made various formulations together with the carrier pharmaceutically accepting or excipient.
Specific embodiment：
Embodiment l：The preparation of granule
Weigh material medicine according to following weight portion：20 parts of turmeric, 20 parts of rheum officinale, 15 parts of rhizoma alismatis, 15 parts of the fruit of glossy privet, grape pip 15 Part, 15 parts of potentilla discolor.
Above-mentioned raw materials medicine mixing and water adding is decocted twice, the addition of water is 8 times that material medicine believes total weight parts, often Secondary decoction 2 hours, decoction liquor filters, and filtrate merges, and stands 12 hours, takes supernatant concentration to relative density to be 1. 20- 1.30 (50-70 DEG C), are mixed as extract powder with above-mentioned 200 mesh impalpable powders, take extract powder：Dextrin：Starch：Microcrystalline cellulose one 5：1：2：2, mix, pelletize, be dried, make particle, obtaining final product name of product is hypoglycemic granule.
Embodiment 2：The preparation of granule
Weigh material medicine according to following weight portion：20 parts of turmeric, 20 parts of rheum officinale, 15 parts of rhizoma alismatis, 15 parts of the fruit of glossy privet, grape pip 15 Part, 15 parts of potentilla discolor.
Above-mentioned raw materials medicine mixing and water adding is decocted twice, the addition of water is 8 times of material medicine total weight parts, every time Decoct 2 hours, decoction liquor is filtered. merging filtrate, it is concentrated into medicinal extract, dry, pulverize into 200 mesh fine powders；Add appropriate auxiliary Material starch, mixes, and prepared name of product is hypoglycemic granule.
Embodiment 3：The preparation of capsule
Weigh material medicine according to following weight portion：20 parts of turmeric, 20 parts of rheum officinale, 15 parts of rhizoma alismatis, 15 parts of the fruit of glossy privet, grape pip 15 Part, 15 parts of potentilla discolor.
Above-mentioned raw materials medicine mixing and water adding is decocted twice, the addition of water is 8 times of material medicine total weight parts, every time Decoct 2 hours, filter, filtrate merges, stand 12 hours, take supernatant concentration to being dried in right amount, load capsule, obtain final product product Entitled Jiangtang capsule.
Embodiment 4：The preparation of oral liquid
According to weight meter（Every weight portion is l kilogram）Weigh material medicine：20 kilograms of turmeric, 20 kilograms of rheum officinale, 15 kilograms of rhizoma alismatis, 15 kilograms of the fruit of glossy privet, 15 kilograms of grape pip, 15 kilograms of potentilla discolor.
Above-mentioned raw materials medicine mixing and water adding is decocted twice, adds 8 times amount water every time, decocting the weight adding water every time is raw material 8 times of medicine gross weight, decoct 2 hours every time, filter, merging filtrate, stand 12 hours, take supernatant concentration to appropriate, Mix with above-mentioned impalpable powder, add flavor enhancement, Preservative qs, mix, making name of product is oral liquid for decreasing blood sugar.
Embodiment 5：The preparation of pill
According to weight meter（Every weight portion is l kilogram）Weigh material medicine：20 kilograms of turmeric, 20 kilograms of rheum officinale, 15 kilograms of rhizoma alismatis, 15 kilograms of the fruit of glossy privet, 15 kilograms of grape pip, 15 kilograms of potentilla discolor.
Above-mentioned raw materials medicine mixing and water adding is decocted twice, decocting the weight adding water every time is the 8 of material medicine gross weight Times.Decoct 2 hours every time, filter, merging filtrate, be concentrated into medicinal extract, dry, pulverize into fine powder；Add appropriate all enter starch Deng auxiliary material, mix, water general for ball, with Plant Soot coating, hit light, be dried, obtaining final product name of product is Jiangtangwan pill.
Excipient in preparation method of the present invention, the addition of auxiliary material, according to the concrete condition in preparation process, flexibly slap Hold, that is, " appropriate " described in literary composition.
Instructions of taking：Granule, three times a day, one bag every time, 10 grams every bag；Capsule, three times a day, 3 every time, every 0. 35 grams；Oral liquid, three times a day, each l0ml；Pill：Three times a day, every time 30,0.1 gram every.Before meals or aftermeals With.
Note：Children or hypoglycemia person should not take.The present invention is anxious through North China central laboratory of the college of traditional Chinese medicine of Polytechnics Property toxicity test prove, this product acute oral toxicity experiment display no overt toxicity.
The impact to diabetes B rat blood sugar for the hypoglycemic granule
（One）Materials and methods
(1) positive control drug double benefit hypoglycemic granule：There is provided by Lunan Pharmaceutical Co., Ltd..(authentication code：Traditional Chinese medicines ≯ Cui word 210950075)
(2) animal wistar rat, is purchased from institute of lab animals of China Concord Medical Science University of Chinese Academy of Medical Sciences Beijing Kang Lan Bioisystech Co., Ltd, SPF level, animal quality certification number：SCXK<Capital>2009-0004, body weight 120 ± 209.It is hero Property.
(3) reagent Streptozotocin is provided by Beijing universal love port commerce trading center.
(4) method takes 70 wistar rats, is randomly divided into 7 groups, i.e. blank control group（Salt solution）, model group, Western medicine pair According to group, Chinese medicine control group, this medicine high dose group, middle dose group, low dose group.Weigh weekly 1 time, and accordingly adjustment dispensing Amount, is used in conjunction 4 weeks, and activities in rats situation observed to salt solution and at any time by control group list, in administration 4 weeks, takes a blood sample every group of mensure from tail point Blood sugar of rat etc., put to death administration group control group all animals in 4 weeks, and takes main organs, sent pathological tissue room to check.
（Two）Result
(1) the impact administration group rat to animal ordinary circumstance is compared with blank control group, ordinary circumstance Non Apparent Abnormality.
(2) blood sugar inspection result medicine of the present invention postprandial blood sugar and fasting blood-glucose compared with model group significantly reduces（P< 0.05）, postprandial blood sugar and fasting blood-glucose there was no significant difference (P compared with melbine group, double benefit hypoglycemic granule group>0.05) (table 1).
The test impact of each material medicine in the present invention：
1st, the impact to diabetes B rat kidney and pathology of livers for the curcumin in the present invention
Method：100 male Wistar rats are randomly divided into two groups:10 rats are blank control group, and 90 rats are T2DM modeling group, using low dose of Streptozotocin (30mg/kg BW) joint high glucose and high fat feed induction T2DM model group.Mould After type induction success, meet the rat 39 of T2DM standard, be randomly divided into 4 groups:T2DM model control group, curcumin low dose group (50 mg/kg BW), curcumin middle dose group (150 mg/kg BW) and curcumin high dose group (250 mg/kg BW), give Intervene.After 45 days, randomly select 4 from each group rat and carry out pathological examination, observe the pathology of T2DM rat kidney and liver Progress.Result compared with control group, all significantly raised (P of the rat blood sugar of T2DM model group, blood fat<0.05).With T2DM Model control group compares, and the pathological change of curcumin intervention groups T2DM rat kidney and liver all has different degrees of improvement. Conclusion curcumin can improve the pathological change of T2DM rats'liver, nephridial tissue.
2nd, the impact that curcumin is expressed to spinal cord of diabetic rats dorsal horn TNF-α
Method：30 SD male rats are randomly divided into control group (Con), diabetes group (DM) and curcumin treatment group (DM+ ), Cur every group 10;Prepare rat diabetes model using lumbar injection Streptozotocin (STZ), DM+Cur group is diabetes Model gives turmeric extract for treating after being successfully prepared, Con group and DM group give the physiological saline of equivalent simultaneously.Using ELISA method The content of detection each group Rat Spinal Dorsal TNF-α molecule, compares each group Rat Spinal Dorsal TNF-α using RT-PCR method The expression of mRNA.Result:Successfully prepare IDDM (TIDM) rat model, this model has hyperglycaemia, quality mitigates, many The features such as drink, many foods, diuresis, ELISA testing result display Con group, DM group and DM+Cur group Rat Spinal Dorsal TNF-α molecule Content is respectively:21 ± 6 pg/mL, 145 ± 11 pg/mL and 80 ± 7pg/mL, DM group TNF-α molecule content apparently higher than Con group (P<0.05) after, giving turmeric extract for treating, DM+Cur group TNF-α is remarkably decreased, but remains above Con group (P<0.05). RT-PCR testing result display DM group Rat Spinal Dorsal TNF-α mRNA is higher than Con group, after giving turmeric extract for treating, DM+Cur Group TNF-α mRNA decreases compared with DM group, and this trend is consistent with ELISA result.Conclusion:The TIDM rat ridge of STZ induction The expression of marrow dorsal horn TNF-α increases, and Turmeric element can reduce the expression of TIDM rat marrow dorsal horn TNF-α.
3rd, the experimental study to diabetes rat vascular lesion protection mechanism for the rheum officinale
Method:Prepare diabetes rat model, and give rheum officinale intervention, after 8 weeks, take hematometry nitric oxide (NO) and endothelium Plain -1 (ET-1).Take the acetylcholine (Ach) that thoracic aortic ring observes different cumulative concentrations that norepinephrine (NE) is caused Vasoconstrictive inhibiting rate.Separately leave and take one section of aorta pectoralis and prepare pathological section, SP method immunohistochemical staining, between observation of cell Adhesion molecule -1 (ICAM-1) and the positive expression of vascular intercellular adhesion molecule-1 (VCAM-1).Result:Rheum officinale group and model Group compares the blood plasma ET-1 (P that can substantially suppress to raise<0.05);Level (the P of elevation of NO<0.05);But all do not reach normal group Level (P<0.05).Model group vascular circle is significantly stronger than Normal group and rheum officinale group (P to the contractile response of NE<0.05), And rheum officinale group is also better than Normal group (P to the contractile response of NE<0.05).Under identical Ach concentration, model group and rheum officinale group Thoracic aortic ring is markedly less than normal group (P to the diastole effect of Ach<0.05), and rheum officinale group is better than model group (P<0.05).Greatly Huang Zuneng substantially suppresses diabetes rat aorta pectoralis ICAM-1 and VCAM-1 expression (P<0.05).Conclusion:Rheum officinale has reduction Rat ET-1 and the effect of elevation of NO, can protect the arterial dilation that diabetes rat endothelium relies on, and can suppress The expression of ICAM-1 and VCAM-1, has anti arteriosclerosis effect.
4th, the impact to BDNF, iNOS and oxidative stress in diabetes mellitus encephalopathy rat hippocampus for the Chrysophanol
Method:The application water maze laboratory detection impact to diabetes rat model learning and memory for the Chrysophanol;Application RNA isolation kit Cholinesterase (AChE) in detection different experiments group hippocampus, CAT (ChAT), BDNF (BDNF), the activity of nitric oxide synthase type (iNOS) and oxidative stress index of correlation (CAT, SOD, GSH).Result rheum officinale Phenol improves the ability of learning and memory of diabetes rat model, enhances AChE and BDNF in diabetes rat model group hippocampus Activity, inhibits the activity of ChAT, iNOS, CAT, SOD and GSH in model group hippocampus.Conclusion Chrysophanol may be by strengthening The activity of BDNF, the function of downward iNOS and anti-oxidant approach are thus produce protective effect to diabetes mellitus encephalopathy, it is likely to become The newtype drug of clinical treatment diabetes mellitus encephalopathy.
5th, the impact to diabetes B mouse blood sugar, insulin level for the rheum emodin
Method:Blood sugar all >=the SPF level KKAy mouse 40 of 13.9 mmol/L, be randomly divided into model group (gavaging sterilized water), Basic, normal, high dosage Effects of Emodin group [giving 12.5,25,50 mg/ (kg.d) rheum emodin gavages respectively] and Mellitus Model With Pioglitazone Group [gives 1.95 mg/ (kg.d) gavage], successive administration 8 weeks.Each group mouse fasting blood-glucose (FPG), empty stomach pancreas islet is measured after 8 weeks Plain (FINS), and calculate insulin sensitivity index (ISI);Measure PI3-K in mice skeletal and adipose tissue with RT-PCR method And the mRNA of GluT4.Result is compared with model group, basic, normal, high dosage Effects of Emodin group and Mellitus Model With Pioglitazone group mouse FPG, FINS, ISI all substantially reduce (P is equal<0.05), and in dose dependent.High dose Effects of Emodin group group FINS, ISI (P is equal to be above Mellitus Model With Pioglitazone group<0.05).Compared with model group, basic, normal, high dosage Effects of Emodin group and pyrrole lattice arrange The mRNA of ketone treatment group mouse PI3-K, GluT4 substantially increases that (P is equal<0.05).Conclusion rheum emodin has good hypoglycemic, fall Low insulin level and raising insulin sensitivity effect, its mechanism may be relevant with PI3-K, GluT4 gene.
6th, Alisma extract is to the treatment of Streptozotocin hyperglycaemia mouse and protective effect
Method：1. cause diabetes animal model to mouse peritoneal injection STZ 15 0mg kg-1.igRAE 1.5、3.0g•kg- 1,1,2 and 5h mensure blood sugar before administration and after administration;Blood sugar and blood fat is surveyed after continuous treatment 15d.2. continuous IgRAE 1.5,3.0g kg-13d, then ipSTZ 10 5mg kg-1, and continual cure 3d, survey serum islet with putting method of exempting from Element, takes pancreas to change in light Microscopic observation islet tissue.Result RAE therapeutic administratp can obviously reduce STZ diabetic mice Blood sugar and triglycerides.Preventing and treating administration can substantially resist the blood glucose rise of STZ induction and islet tissue changes, and can raise Serum insulin level.Conclusion RAE has obvious treatment and protective effect to STZ diabetic mice.
7th, the impact of Extract from Rhizoma Alismatis on Normal and Alloxan Model in Mice
Method:To mouse tail vein injection alloxan 90mg kg- 1, cause diabetes model.Mensure blood sugar (Glu), Triglycerides (Trig), cholesterol (Chol), amylopsin (Amy) and serum insulin (Ins).Light Microscopic observation pancreas Histological change with pancreas islet.Result:RAE can make normal mouse blood sugar substantially reduce.Treatment can make alloxan mouse in 7 days Glu and Trig reduces.Alloxan mouse after light Microscopic observation RAE treatment, pancreas islet keeps normal histology's form.RAE is also Can increasing serum Ins level and the Amy reduction resisting model induced by alloxan.
8th, fruit of glossy privet hypoglycemic activity
With fruit of glossy privet water decoction 15,30g/kg to mouse stomach 10 days, the blood sugar of normal mouse can be reduced, alloxan is drawn The diabetes mice rising has prevention and therapeutic action, and the blood glucose rise that antiadrenergic drug or glucose can be caused.
Oleanolic Acid in Herbal Ligustrum lucidum anti-diabetic effect
The fruit of glossy privet is the traditional Chinese medicine of China, is commonly used to the diseases such as treating cancer, hepatitis, though having been reported that at hypoglycemic aspect, But lack system in-depth study.
8th, anti-nonenzyme glycosylation effect of Grape Seed Proanthocyanidin Extract in Diabetic Rats experimental study
Observe the impact to non-enzymatic glycation in diabetes rat body for the grape seed polyphenols (GSPE), evaluate it slow to diabetes The intervention effect of property complication (DCC).Methods Ratss lumbar injection Streptozotocin (STZ) 60mg/kg causes glycosuria Disease model, is randomly divided into blank control group, aminoguanidine (150mg kg-1 d-1) treatment group, basic, normal, high 3 dosage of GSPE (50,150,450mg kg-1 d-1) treatment group, every group 12, another 12 are set to Normal group.Routine feeding took after 12 weeks Rat blood serum and internal organs, compare each group kidney weight/body weight ratio, compare each group cortex renis non-glycosylation end-product with fluorescence method (AGEs), full automatic biochemical apparatus detection blood sugar, T-CHOL (TC) and triglycerides (TG).Result is compared with blank control group, GSPE can significantly reduce diabetes rat kidney weight/body weight ratio (P<001), reduce cortex renis AGEs (P<001), in GSPE, High dose group and aminoguanidine treatment group act on similar;GSPE does not make significant difference to blood sugar, TG, only GSPE middle dose group TC with normal Control group comparing difference has conspicuousness (P<001).Conclusion GSPE can suppress internal non-enzymatic glycation, is that it prevents and treats DCC One of main mechanism.
9th, the antioxidation to diabetic mice for the Grape Seed Extract Procyanidin
Method:Diabetes model is prepared with alloxan mouse, by the mouse after modeling success, be divided into model group, GSEP low, Middle and high 3 dosage (50,100,150 mg/kg) group, separately sets Normal group.After successive administration 28 d, on an empty stomach after 12 h, take Whole blood and liver, measure Sudismase (SOD) and glutathione peroxidase (GSH-Px) vigor in whole blood and hepatic tissue And MDA (MDA) content.After result orally administration mouse GSEP 28 d, SOD in high dose group Mouse whole blood and hepatic tissue With GSH-Px activity obviously higher than model group (P<0.05), MDA (MDA) in middle and high dosage group Mouse whole blood and hepatic tissue Content is all significantly lower than model group (equal P<0.05).Conclusion GSEP has obvious anti-oxidation protection effect to diabetic mice.
10. the effect to diabetic mice serum insulin and insulin antibody for the potentilla discolor flavones
Method：Potentilla discolor obtains chromocor extract through solvent extraction, polyamide column separation and Extraction；Made with alloxan lumbar injection Mould, successful for modeling mouse is randomly divided into as high dose（216mg•kg^-1•d^-1）, low dosage（108mg-kg^-1•d^- 1）, model control group.After successive administration 14d, observe potentilla discolor flavones to diabetic mice body weight, blood sugar, serum insulin and The impact of insulin antibody.Result potentilla discolor flavones can reduce the blood sugar of diabetic mice well, improves serum insulin Level, but on Serum Insulin Antibodies impact less.Conclusion potentilla discolor flavones is to the therapeutic action of diabetes it may be possible to by fall Low blood glucose level to be realized with raising serum insulin level.
The impact to diabetes B insulin resistance rat glycolipid metabolism for the 11. potentilla discolor Aqueous extracts
Method：Using 3 week old Wistar rats, high fat diet 16 weeks plus abdominal cavity dose injection Streptozotocin（STZ）Side Method sets up diabetes B insulin resistance（IR）Animal model, is randomly divided into 4 groups：Potentilla discolor high and low dose group（400,200 mg.kg-1）, Pioglitazone group（4.05 mg.kg-1）And model group, every group 7.Fed standard chow rat 7 is separately taken just to be Often group.Compare each pharmaceutical intervention after 4 weeks to diabetes B IR rat fasting blood-glucose（FBG）, triglycerides（TG）, cholesterol （TC）, low-density lipoprotein（LDL-C）, HDL（HDL-C）And free fatty（FFA）Impact.Result：Potentilla discolor Extract and Western medicine group all can significantly reduce rat FBG, TG, TC, LDL, FFA level, raising HDL levels（P〈0.05）.Conclusion： Potentilla discolor has certain adjustment effect to the fasting blood-glucose of diabetes B insulin resistance rat and blood lipid level.
12. potentilla discolor general flavones lead to 2 patients with type Ⅰ DM rat insulin substrate -2- phosphatidylinositols -3 kinase signal The impact on road
Method:Potentilla discolor obtains extractive of general flavone through solvent extraction, polyamide column separation and Extraction;Chain is added with high fat high sugar emulsion Urea assistant rhzomorph replicates diabetes B rat model, and successful for modeling rat is randomly divided into potentilla discolor general flavone high dose (216 Mg kg 1) and low dosage (108 mg kg 1), model control group, positive drug group (Metformin hydrochloride suspension 20.8 mg ), kg-1 successive administration, after 4 weeks, observes the change of its blood sugar, blood fat, free fatty, hepatic glycogen, insulin level, adopts Western blots method detects the expression of hepatic tissue IRS-2 and PI-3K albumen.Result:Compare with normal group, model group rats Body weight loss, blood sugar and T-CHOL (TC) raise;HDL-C (HDL-C) declines (P0.05).With model Group compares, and potentilla discolor general flavone high dose group blood sugar declines (P0.05), and TC declines, and HDL-C raises (P0.05);Insulin and pancreas Insulin resistance index all reduces (P0.05);The expression of hepatic tissue IRS-2 and PI-3K albumen raises (P0.05).Conclusion:Turn over Careless general flavone can correct diabetes B rat carbohydrate metabolism disturbance it may be that by reducing the output reducing hepatic glycogen, improving in vain Hepatic tissue insulin IRS-2-PI3-K protein expression, thus weaken peripheral insulin resistance.

Claims (3)

1. a kind of compound Chinese medicinal preparation treating diabetes B is it is characterised in that this compound Chinese medicinal preparation is by following weight parts Material medicine make：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, 5～30 parts of the fruit of glossy privet, grape pip 5～ 30 parts, 5～30 parts of potentilla discolor.
2. a kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, comprises the steps：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract；
B. dry, pulverize into fine powder as active component；
C. the active component described in step b is made various formulations together with the carrier pharmaceutically accepting or excipient.
3. a kind of preparation method of the compound Chinese medicinal preparation treating diabetes B, the method is water extraction, comprises the steps：
A. weigh material medicine according to weight portion：10～40 parts of turmeric, 10～40 parts of rheum officinale, 5～30 parts of rhizoma alismatis, the fruit of glossy privet 5～ 30 parts, 5～30 parts of grape pip, 5～30 parts of potentilla discolor；Add water to cook twice, by weight, the addition decocting water every time is 8 times of material medicine total weight parts, decoct 2 hours every time, filter, merging filtrate, are concentrated into medicinal extract, as active component；
B. the active component described in step a is made various formulations together with the carrier pharmaceutically accepting or excipient.
CN201610998764.3A 2016-11-14 2016-11-14 Traditional Chinese medicine compound preparation for curing 2-diabetes Pending CN106390034A (en)

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