CN104667107A - Medicine for treating summerheat injuring lung and stomach summer fever in children and preparation method of medicine - Google Patents

Medicine for treating summerheat injuring lung and stomach summer fever in children and preparation method of medicine Download PDF

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CN104667107A
CN104667107A CN201510118296.1A CN201510118296A CN104667107A CN 104667107 A CN104667107 A CN 104667107A CN 201510118296 A CN201510118296 A CN 201510118296A CN 104667107 A CN104667107 A CN 104667107A
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radix
fructus
herba
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孔春妍
朱靖
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孔春妍
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Abstract

The invention discloses a medicine for treating summerheat injuring lung and stomach summer fever in children and a preparation method of the medicine. The medicine comprises the following active ingredients: purple flower holly leaves, cassia bark, radix rehmanniae recen, turtle shells, sweet wormwood, Chinese yam, chela, blackberry lily, fructus aurantii immaturus, fissistigma oldhamii, nard, saussurea nigrescens maxim, aspongopus, viola diffusa ging, sword beans, twin-sorus fern, herba eupatorii, radix bupleuri, semen coicis, lepidogrammitis rostrata, shrubalthea bark, rush, smilax, acanthopanax, radix ceratostigmae, fructus psoraleae, tamarind pulp, alpiniae oxyphyllae fructus, cuscuta chinensis, fritillary bulb, fructus forsythiae, gardneria multiflora, adenosma indianum, polygonatum odoratum and rapanea neriifolia. The medicine has the benefits that the medicine has effects of clearing away summerheat, nourishing yin and promoting production of body fluid, mainly treats the summerheat injuring lung and stomach summer fever in the children, achieves syndrome differentiation and treatment based on a holism concept by using the traditional Chinese medicine theory, and has the advantages that the medicine takes effect quickly, is high in efficiency, exact in curative effect, short in treatment course and appropriate in taste, has no toxic or side effects, and is easily accepted by a patient.

Description

A kind ofly treat medicine of summer-heat impairing the lung gastric pattern disease of wean hotness and preparation method thereof
Technical field
The present invention relates to technical field of medicine, particularly a kind ofly treat medicine of summer-heat impairing the lung gastric pattern disease of wean hotness and preparation method thereof .
Background technology
Febrile disease due to summer-heat pathogen is infant a kind of peculiar disease in period, and clinical few for feature with summer has set in long-term fever, thirsty polydipsia, polyuria, perspiration stagnation or antiperspirant, after cool autumn days, symptom can spontaneous regression.It is generally acknowledged that temperature is hot, thermotaxic centre functional disorder, sweat gland secretion reduces or caused by lacking.Primary disease is multiple in 6 ~ August, and some infant often can be fallen ill the several years continuously.
The etiology and pathogenesis of febrile disease due to summer-heat pathogen: the pathogenic factor of febrile disease due to summer-heat pathogen is main relevant with child physical endowment factor, has because children's's natural endowment is not enough, as premature infant, premature infant, deficiency of kidney-QI person; Have because the taste day after tomorrow are not enough, development nutrition is poor, weakness of the spleen and stomach person; Have because body is empty after being ill, deficiency of both vital energy and Yin person, the stifling of summer-heat weather can not be tolerated after summer has set in, easily suffer from primary disease.
Primary disease is fallen ill because summer heat is stifling, the moon of feeling frustrated more, and whether dialectical will difference involves part of the body cavity above the diaphragm housing the heart and lungs lung gastric qi the moon, still undermines the yang-energy of kidney of lower warmer.At the disease initial stage, how not show sickly complexion, but the thirsty polydipsia that generates heat, food of receiving is as usual, red tongue, rapid pulse, is summer-heat impairing the lung stomach card; Generate heat persistent, thereupon polydipsia polyuria, appetite is gradually shown in and goes down, and complexion occurs pale, and health is day by day become thin, xerocheilia, skin burns, and acra owes temperature, and metal fatigue, light red tongue, arteries and veins is unable, be then syndrome of upper excess and lower deficiency.
Analyze the cause of disease of disease of wean hotness, therefore distinguish that its clinical syndrome is divided into: 1, summer-heat impairing the lung gastric pattern: generate heat persistent, the how afternoon rising of calorific potential, delay and do not move back, temperature is higher, generates heat also higher, thirst and drinking, neck is hotter, and xerosis cutis is scorching hot, lossless or hypohidrosis, frequent micturition and long clearly, spirit is irritated, xerocheilia, red tongue, yellow and thin fur, rapid pulse.Summer-heat impairing the lung stomach, the loss of gas the moon.Infant innate deficiency, emits by summer heat, accumulates in lung stomach, cloudy Tianjin of burning, body fluid deficiency and interior-heat is flourishing, therefore long-term fever does not move back, thirst and liking drink; Summer-heat is more contained, and stifling hotter, heat is excessive in interior, therefore heating is higher, and spirit is irritated; Shang Zehua source, lung Tianjin is not enough, and water liquid is difficult compress, therefore neck, skin are scorching hot, lossless or hypohidrosis; Summer-heat is felt frustrated, though again and again thirsty drink, and the bladder that becomes under QI failing to transform into body fluid, occur that frequent micturition is long clearly; The loss by burning of lung stomach-Yin Tianjin, therefore skin, xerocheilia.Tongue fur BOHUANG, rapid pulse is the card that summer heat is hindered.2, upper excess and lower deficiency type: lethargy or fidgets due to deficiency uneasiness, pale complexion, lower limb are chilly, inappetence, and urine is clarified, and frequency is immoderate, loose stool, and fever of the body does not move back, and decline dusk towards Sheng, thirsty polydipsia, light red tongue yellow fur, thready and rapid pulse without strength.Heat excessive in upper, yang deficiency under.Assertive evidence is more common in body and is reported weak, and in the later stage that patient's condition is touching, deficiency and excess is also shown in, empty more than reality.Decline of the fire from the gate of life, can not warm spleen soil, therefore clinically occur pale complexion, lethargy, loss of appetite, loose stool, and lower limb are chilly, and urine clarification is as the sign of a series of taste YANG QI deficiency such as water.Summer heat is for suffering from, and cloudy liquid must consume, hyperactivity of fire caused by deficiency of YIN, therefore heating is not moved back, and declines dusk towards Sheng, thirsty polydipsia; Though life fire belongs to kidney yang, and reside among kidney yin, kidney also known as viscus attributed to water and fire, the not good fire of water, then YANG transmission is more floating, therefore visible fidgets due to deficiency does not rather wait syndrome of upper excess and lower deficiency; Light red tongue yellow fur, thready and rapid pulse without strength is then intermingling cold and heat, deficiency and excess resembling of seeing.
Western medical treatment disease of wean hotness mainly contains the following aspects: 1. infant room maintains the circulation of air, clean nice and cool.If desired can using air-condition, general room temperature controls at 26 ~ 28 DEG C Celsius, unsuitable too low.2. diet should be light, being rich in nutrition, suitably supplements some vitamin B group and vitamin C.
But western medical treatment disease of wean hotness therapeutic scheme limits to, types of drugs is selected limited, and clinical therapeutic efficacy is relatively not satisfactory.
Summary of the invention
Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of summer-heat impairing the lung gastric pattern disease of wean hotness and preparation method thereof, the present invention has clearing away summer-heat, effect of YIN nourishing and the production of body fluid promoting, cures mainly the little febrile disease due to summer-heat pathogen of summer-heat impairing the lung gastric pattern, utilizes Traditional Chinese medical theory, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out on the basis of organic conception, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, mouthfeel is suitable for, and patient is easy to the advantages such as acceptance.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine treating summer-heat impairing the lung gastric pattern disease of wean hotness, wherein, following raw medicinal material is comprised: Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 10 ~ 25 parts, Cortex Cinnamomi 13 ~ 27 parts, Radix Rehmanniae 15 ~ 34 parts, Carapax Trionycis 12 ~ 31 parts, Herba Artemisiae Annuae 14 ~ 36 parts, Rhizoma Dioscoreae 12 ~ 32 parts, Hippopus hippopus (Linnaeus) 10 ~ 20 parts, Rhizoma Belamcandae 12 ~ 26 parts, Fructus Aurantii Immaturus 10 ~ 24 parts, Radix Fissistigmatis Oldhamii 15 ~ 35 parts, Radix Et Rhizoma Nardostachyos 12 ~ 24 parts, Herba saussureae nigrescentis 11 ~ 31 parts, Aspongopus 13 ~ 30 parts, Climbing Viloet Herb 15 ~ 38 parts, Semen Canavaliae 12 ~ 26 parts, Diplazium lanceum (Thunb) 10 ~ 24 parts, Herba Eupatorii 14 ~ 35 parts, Radix Bupleuri 10 ~ 22 parts, Semen Coicis 11 ~ 31 parts, dominoes Herba pteridii latiusculi 16 ~ 37 parts, Cortex Hibisci 13 ~ 30 parts, Medulla Junci 13 ~ 34 parts, Rhizoma Smilacis Chinensis 13 ~ 36 parts, Radix Et Caulis Acanthopanacis Senticosi 7 ~ 22 parts, Radix ceratostigmatis willemottiani 12 ~ 33 parts, Fructus Psoraleae 15 ~ 37 parts, Fructus Tamarindi Indicae 10 ~ 35 parts, Fructus Alpiniae Oxyphyllae 7 ~ 20 parts, Semen Cuscutae 12 ~ 25 parts, Bulbus Fritillariae Ussuriensis 16 ~ 38 parts, Fructus Forsythiae 13 ~ 30 parts, Peng Lai Pueraria lobota 12 ~ 31 parts, Herba Adenosmae Glutinosi 13 ~ 28 parts, Rhizoma Polygonati Odorati 14 ~ 28 parts and 12 ~ 35 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 12 ~ 23 parts, Cortex Cinnamomi 15 ~ 25 parts, Radix Rehmanniae 16 ~ 31 parts, Carapax Trionycis 15 ~ 24 parts, Herba Artemisiae Annuae 15 ~ 26 parts, Rhizoma Dioscoreae 14 ~ 30 parts, Hippopus hippopus (Linnaeus) 13 ~ 20 parts, Rhizoma Belamcandae 14 ~ 24 parts, Fructus Aurantii Immaturus 11 ~ 21 parts, Radix Fissistigmatis Oldhamii 16 ~ 34 parts, Radix Et Rhizoma Nardostachyos 14 ~ 22 parts, Herba saussureae nigrescentis 12 ~ 30 parts, Aspongopus 15 ~ 28 parts, Climbing Viloet Herb 16 ~ 35 parts, Semen Canavaliae 14 ~ 25 parts, Diplazium lanceum (Thunb) 12 ~ 21 parts, Herba Eupatorii 15 ~ 32 parts, Radix Bupleuri 13 ~ 21 parts, Semen Coicis 13 ~ 30 parts, dominoes Herba pteridii latiusculi 17 ~ 35 parts, Cortex Hibisci 15 ~ 30 parts, Medulla Junci 14 ~ 32 parts, Rhizoma Smilacis Chinensis 14 ~ 35 parts, Radix Et Caulis Acanthopanacis Senticosi 8 ~ 21 parts, Radix ceratostigmatis willemottiani 14 ~ 31 parts, Fructus Psoraleae 16 ~ 34 parts, Fructus Tamarindi Indicae 15 ~ 35 parts, Fructus Alpiniae Oxyphyllae 9 ~ 17 parts, Semen Cuscutae 14 ~ 23 parts, Bulbus Fritillariae Ussuriensis 18 ~ 32 parts, Fructus Forsythiae 15 ~ 27 parts, Peng Lai Pueraria lobota 14 ~ 30 parts, Herba Adenosmae Glutinosi 15 ~ 26 parts, Rhizoma Polygonati Odorati 15 ~ 20 parts and 13 ~ 31 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Cortex Cinnamomi 24 parts, Radix Rehmanniae 20 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 25 parts, Rhizoma Dioscoreae 28 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 18 parts, Fructus Aurantii Immaturus 11 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 20 parts, Herba saussureae nigrescentis 25 parts, Aspongopus 18 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 22 parts, Diplazium lanceum (Thunb) 12 parts, Herba Eupatorii 31 parts, Radix Bupleuri 18 parts, Semen Coicis 26 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 31 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 18 parts, Fructus Psoraleae 32 parts, Fructus Tamarindi Indicae 30 parts, Fructus Alpiniae Oxyphyllae 14 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 24 parts, Rhizoma Polygonati Odorati 16 parts and 30 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 22 parts, Cortex Cinnamomi 18 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 24 parts, Rhizoma Dioscoreae 30 parts, Hippopus hippopus (Linnaeus) 16 parts, Rhizoma Belamcandae 22 parts, Fructus Aurantii Immaturus 20 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 21 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 33 parts, Semen Canavaliae 16 parts, Diplazium lanceum (Thunb) 20 parts, Herba Eupatorii 32 parts, Radix Bupleuri 21 parts, Semen Coicis 18 parts, dominoes Herba pteridii latiusculi 32 parts, Cortex Hibisci 20 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 35 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, Radix ceratostigmatis willemottiani 30 parts, Fructus Psoraleae 24 parts, Fructus Tamarindi Indicae 32 parts, Fructus Alpiniae Oxyphyllae 13 parts, Semen Cuscutae 21 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 28 parts, Herba Adenosmae Glutinosi 25 parts, Rhizoma Polygonati Odorati 16 parts and 23 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Cortex Cinnamomi 25 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 23 parts, Herba Artemisiae Annuae 19 parts, Rhizoma Dioscoreae 17 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 21 parts, Fructus Aurantii Immaturus 13 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 16 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 20 parts, Diplazium lanceum (Thunb) 15 parts, Herba Eupatorii 32 parts, Radix Bupleuri 20 parts, Semen Coicis 15 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 31 parts, Rhizoma Smilacis Chinensis 19 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 15 parts, Fructus Psoraleae 33 parts, Fructus Tamarindi Indicae 35 parts, Fructus Alpiniae Oxyphyllae 12 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 24 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 23 parts, Rhizoma Polygonati Odorati 17 parts and 27 parts, the frontal bone tip.
Wherein, it is characterized in that, when the dosage form of described medicine is paster agent, its preparation method comprises the following steps:
The first step, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis and dominoes Herba pteridii latiusculi are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, general, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 ~ 2 times of described medicine each raw medicinal material quality sum, the Colophonium of 1 ~ 2 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.
Wherein, when the dosage form of described medicine is enema, its preparation method comprises the following steps:
The first step, by Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the mixing of the frontal bone tip, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae and Bulbus Fritillariae Ussuriensis are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described drug enema agent finished product.
Wherein, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
The invention has the beneficial effects as follows: the present invention has clearing away summer-heat, effect of YIN nourishing and the production of body fluid promoting, cure mainly the little febrile disease due to summer-heat pathogen of summer-heat impairing the lung gastric pattern, utilize Traditional Chinese medical theory, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is carried out on the basis of organic conception, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, mouthfeel is suitable for, and patient is easy to the advantages such as acceptance.
Detailed description of the invention
The invention provides a kind of medicine for the treatment of summer-heat impairing the lung gastric pattern disease of wean hotness, the present invention treats disease of wean hotness, with clearing away summer-heat, YIN nourishing and the production of body fluid promoting is Therapeutic Principle, wherein, comprise following raw medicinal material: Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool." Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out." Ilex purpurea Hassk.[I.chinensis Sims controls cough due to lung-heat, laryngopharynx swelling and pain, pyretic stranguria, dysentery.This product bitter cold, is good at purte the white and relieving heat toxin clearly.Stop up on lung-fire, cough, pharyngalgia and anemopyretic cold; Or invade under pyretic toxicity, the puckery pain of dribbling urination, dysentery person, namely alone this product imitates.Ilex purpurea Hassk.[I.chinensis Sims cures cold heating, cough due to lung-heat, laryngopharynx swelling and pain, the puckery pain of dribbling urination and dysentery, diarrhoea disease.
Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.
Herba Artemisiae Annuae: bitter, pungent, cold.Return liver, gallbladder meridian, three burnt, kidney channels.Function: clear deficiency-heat thoroughly, removing heat from blood, except steaming, removes and steams, preventing the attack (or recurrence) of malaria.For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.This product clearing up internal heat by using drugs of bitter in taste and cold in nature, pungent perfume (or spice) falls apart thoroughly, and the kind the moon that makes divides a latent heat thoroughly to reach outer faling apart, and is fever due to yin deficiency key medicine, has expelling summer-heat in addition, cut cruel merit.
Rhizoma Dioscoreae: sweet in the mouth, property is put down, enter lung, spleen, kidney channel, there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening, cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red card such as swollen, fat of frequent micturition of quenching one's thirst, premature ejaculation of passing out semen, leukorrhagia nebulousurine, skin.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.
Fructus Aurantii Immaturus: bitter, pungent, cold; Return spleen, stomach, liver, heart channel.Compendium of Material Medica: " trifoliate orange is wooden name, is its son in fact, therefore says Fructus Aurantii Immaturus.
Radix Et Rhizoma Nardostachyos: acrid in the mouth, sweet, warm in nature; Return spleen, stomach warp.Compendium of Material Medica: " Radix Et Rhizoma Nardostachyos, it is strongly fragrant that fragrance can open spleen, adds in taste medicine less, gas of being very amusing "." Japan hanako materia medica ": " control abdominal distnetion, the therapeutic method to keep the adverse QI flowing downwards." to have fragrance row loose for Radix Et Rhizoma Nardostachyos, warming spleen and stomach for dispelling cold, regulating QI to relieve pain, the effect of appetizing of being amusing.Cure mainly coldness and pain in the epigastrium distension, anorexia, chest pain, toothache, tumbling down is grieved, beriberi edema, cramp caused by acute vomiting and diarrhea.
Aspongopus: warm in nature, salty in the mouth; Return liver,spleen,kidney warp." book on Chinese herbal medicine newly organized ": " Aspongopus, in worm to good person, enter ball loose in, weak the most suitable to hold up.
Semen Canavaliae: warm in nature, property is put down, and sweet in the mouth is nontoxic." medicine material handbook ": " the kidney invigorating, cold expelling, the therapeutic method to keep the adverse QI flowing downwards, sharp the intestines and stomach, anti-nausea.Control kidney qi deficient, the intestines and stomach is got along well, vomiting, abdominal distention, vomits and diarrhoea." warming the middle warmer and descending qi.Profit the intestines and stomach, anti-nausea, kidney tonifying invigorating primordial QI.
Herba Eupatorii: pungent, flat.Return spleen, stomach, lung meridian.Shennong's Herbal: " main dredging water passages, kills diseases due to noxious agents produced by various parasites, eliminating turbid pathogens.Take QI invigorating for a long time, make light of one's life by commiting suicide not old, being proficient in the law of natural movement." " medicine will ": " deliver damp eliminating, and middleization is turbid.Control summer-heat headache, lossless heating, abdominal distention uncomfortable in chest, sweet greasy in mouth, halitosis." expelling summer-heat and damp, ward off dirty and in.For experiencing heat-damp in summer, cold and heat are had a headache, and accumulate in moistening, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, sweet greasy in mouth, disappears truly, turbid damp obstructing in middle-JIAO, and gastral cavity painful abdominal mass vomiting and nausea is sweet greasy in mouth, halitosis, sialism, and heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.
Semen Coicis: cool in nature, sweet in the mouth, light, return spleen, stomach, lung meridian.The several amino acids of rich in starch and needed by human body, there is the effect such as invigorating spleen to remove dampness, clearing away heat and discharging pus, be applicable to have loose bowels, muscle arteries and veins contracture joint stuffiness, the disease such as edema, beriberi, acute appendicitis, leucorrhea, Semen Coicis can be used as medicine, and is used for treating edema, beriberi, diarrhea due to hypofunction of the spleen etc.Make skin smooth, reduce wrinkle, eliminate effect of pigment spot.Have obvious curative effect to face acne and pachylosis, in addition, it also has absorbability to ultraviolet, and its extractive matter adds in cosmetics also can reach sun-proof and effect that is anti-ultraviolet.
Medulla Junci: to be slightly cold, sweet, light; GUIXIN, lung, small intestinal, urinary bladder channel." Bencao Jingshu ": " Medulla Junci, its light weight leads to, and it is cold in nature, slightly sweet flavor, therefore can tonneau small intestinal steam, descendingly goes out from urine, and small intestinal is the internal organs of the heart, therefore also except heart channel heat also." function relieving stranguria by diuresis, clearing heart fire.
Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is carotene, also containing this constituents in people Ginseng.The excretion of cholesterol can be promoted in human body, the too high disease of blood cholesterol level can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxide dimutase) complex, SOD has good anti-oxidation function, the effect of human immunity and the attack of opposing free radical can be strengthened, there is antioxidation, body immunity can be strengthened, prevent aging and promotion health.
Fructus Psoraleae: acrid in the mouth, hardship, warm in nature, return kidney, spleen channel." property of medicine opinion ": " main man's pain in the lumbar region, the cold capsule of knee joint wets, stupid by all cold numbness, and only normal urination, cold in abdomen." " Kaibao Bencao ": " bone marrow wound loses for main five kinds of strain and seven kinds of impairment, wind cold caused by deficiency, the cold essence stream of kidney and the induced abortion of married woman's vim and vigour." kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, helping inspiration to relieve asthma.Be used for the treatment of impotence due to deficiency of the kidney, soreness of the waist and knees cold type of pain, emission due to deficiency of the kidney, the enuresis, frequent micturition, the Diarrhoea that deficiency of spleen-YANG and kidneyYANG causes.The deficiency and coldness of failure of the kidney in receiving QI is breathed with cough.
Fructus Alpiniae Oxyphyllae: acrid in the mouth, warm in nature; Enter the heart, spleen, kidney channel.The kidney warming controlling nocturnal emission with astringent drugs reducing urination, expectorant is taken the photograph in warming the spleen appetizing, cures mainly Deficiency and coldness of spleen and stomach; Vomiting; Have loose bowels; Coldly in abdomen to educate; The many salivas of mouth; Enuresis due to deficiency of the kidney; Frequent micturition; Seminal emission; Nebulousurine, the diseases such as many salivas.
Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat, nontoxic." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.
Rhizoma Polygonati Odorati: sweet in the mouth, property is put down; Attach to the lung and stomach meridians." property of medicine opinion ": " disease cold and heat time main, interior tonifying for the deficiency, removes asthenia exopathogenic heat, and headache is uneasy, adds and good with it." " Japan hanako materia medica ": " except unhappy, quench the thirst, profit cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, waist foot pain, it is capable fanatical." Compendium of Material Medica: " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient." Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.
Hippopus hippopus (Linnaeus): another name: clam, prosperous pretty young woman.Source: medical material Ji Yuan: be shell or the entirety of Tridacnidae animal Che oyster.
Latin plant animal mineral name: Hippopus hippopus (Linnaeus).Nature and flavor: sweet in the mouth; Salty; Cold in nature.Gui Jing: spleen; Lung meridian.Cure mainly: heat-clearing and toxic substances removing; Removing food stagnancy relieves the effect of alcohol.Main carbuncle on the back carbuncle; Furuncle toxic swelling, wine amasss addiction block.
Bulbus Fritillariae Ussuriensis: nature and flavor: bitter, sweet, is slightly cold.Gui Jing: return lung, heart channel.Cure mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
Peng Lai Pueraria lobota: cure mainly: expelling wind and activating blood circulation.Cure mainly arthritis; Wound hemorrhage is controlled in external.
Herba Adenosmae Glutinosi: nature and flavor: pungent, bitter, temperature.Cure mainly: wind-expelling pain-stopping, dissipating blood stasis for subsidence of swelling, detoxifying and relieving itching.For the poliomyelitis initial stage, stomachache of suffering from cold, rheumatic ostalgia.External traumatic is damaged, and swells and ache, carbuncle furuncle and phyma poison, wasp sting, eczema, urticaria.
Rhizoma Smilacis Chinensis: nature and flavor: sweet, sour, flat.Cure mainly: expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling.Root stock: dispelling the wind and dampness pathogens arthralgia, traumatic injury, gastroenteritis, dysentery, dyspepsia, diabetes, chyluria, leucorrhea, cancer; Leaf: carbuncle furuncle furuncle is controlled in external, scalds.
Diplazium lanceum (Thunb): nature and flavor: sweet, pungent, micro-hardship, cold.Cure mainly: herb: clearing away heat and cooling blood, diuresis.Cure mainly hemoptysis of pulmonary tuberculosis, hematuria, lung abscess, children's's heat of a specified duration is not moved back, dysentery, dysuria or urine retention.
Climbing Viloet Herb: nature and flavor: bitter, micro-pungent, cold.Cure mainly: heat-clearing and toxic substances removing, detumescence and apocenosis.For hepatitis, pertussis, conjunctival congestion and swelling pain; Acute mastitis is controlled in external, furuncle, carbuncle furuncle, herpes zoster, venom, traumatic injury.
Herba saussureae nigrescentis: nature and flavor: bitter, pungent, cool.Cure mainly: promoting blood flow to regulate menstruation, clearing away heat to improve acuity of vision.Cure mainly menoxenia, chronic consumptive disease hectic fever due to YIN-deficiency, order disease.
Radix Fissistigmatis Oldhamii: nature and flavor: micro-pungent, temperature.Cure mainly: expelling wind and activating blood circulation, analgesia.Cure mainly sciatica, arthritis, traumatic injury.
The frontal bone tip: nature and flavor: light, cold.Cure mainly: heat-clearing and toxic substances removing, removing heat from blood, damp eliminating.Control mastitis from the beginning of.Eczema is controlled in external, furuncle.
Dominoes Herba pteridii latiusculi: nature and flavor: micro-bitter, sweet, flat.Nontoxic.Cure mainly: clearing away heat and promoting diuresis, relieving restlessness, lung heat clearing gas.Cure mainly and drench the drop difficulty in urination, heat syndrome cough, vexed.
Cortex Hibisci: nature and flavor: sweet, tepor.Cure mainly: clearing away heat-damp and promoting diuresis, killing parasites for relieving itching.For dysentery, leucorrhea; Eczema scrotum tinea corporis is controlled in external, tinea pedis.
Cyananthus argernteus marg.: nature and flavor: sweet in the mouth; Bitter; Warm in nature.Cure mainly: the attached temperature of spleen invigorating; Relaxing muscles and tendons and activating QI and blood in the collateral.Main insufficiency of the spleen weak; Infantile diarrhea; Rheumatic arthralgia; Traumatic injury.
Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Cure mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.Fructus Tamarindi Indicae Fructus Tamarindi Indicae: source: " choosing of Yunnan Chinese herbal medicine ".Nature and flavor: sweet acid are cool.Cure mainly: clearing away summer-heat heat, eliminate indigestion is stagnant.Control summer-heat inappetence, vomiting during pregnancy, infantile malnutrition.
Fructus Forsythiae: nature and flavor: bitter, is slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Rhizoma Belamcandae: nature and flavor: bitter, cold.Gui Jing: return lung meridian.Cure mainly: heat-clearing and toxic substances removing, expectorant, sore-throat relieving.For the pent-up of pyretic toxicity phlegm-fire, laryngopharynx swelling and pain, accumulation and obstruction of sputum, cough and asthma.
Radix ceratostigmatis willemottiani: nature and flavor: sweet, acrid, warm.Cure mainly: spasmolytic, analgesia.For gastritis, gastric ulcer, ascariasis of biliary tract, the pain that cholecystitis and ascariasis cause.
Carapax Trionycis: nature and flavor: salty, is slightly cold.Gui Jing: return liver, kidney channel.Curing mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, bringing down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea , WEIJIA, chronic malaria malaria with splenomegaly.
Cortex Cinnamomi: nature and flavor: pungent, sweet, hot greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Cure mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 10 ~ 25 parts, Cortex Cinnamomi 13 ~ 27 parts, Radix Rehmanniae 15 ~ 34 parts, Carapax Trionycis 12 ~ 31 parts, Herba Artemisiae Annuae 14 ~ 36 parts, Rhizoma Dioscoreae 12 ~ 32 parts, Hippopus hippopus (Linnaeus) 10 ~ 20 parts, Rhizoma Belamcandae 12 ~ 26 parts, Fructus Aurantii Immaturus 10 ~ 24 parts, Radix Fissistigmatis Oldhamii 15 ~ 35 parts, Radix Et Rhizoma Nardostachyos 12 ~ 24 parts, Herba saussureae nigrescentis 11 ~ 31 parts, Aspongopus 13 ~ 30 parts, Climbing Viloet Herb 15 ~ 38 parts, Semen Canavaliae 12 ~ 26 parts, Diplazium lanceum (Thunb) 10 ~ 24 parts, Herba Eupatorii 14 ~ 35 parts, Radix Bupleuri 10 ~ 22 parts, Semen Coicis 11 ~ 31 parts, dominoes Herba pteridii latiusculi 16 ~ 37 parts, Cortex Hibisci 13 ~ 30 parts, Medulla Junci 13 ~ 34 parts, Rhizoma Smilacis Chinensis 13 ~ 36 parts, Radix Et Caulis Acanthopanacis Senticosi 7 ~ 22 parts, Radix ceratostigmatis willemottiani 12 ~ 33 parts, Fructus Psoraleae 15 ~ 37 parts, Fructus Tamarindi Indicae 10 ~ 35 parts, Fructus Alpiniae Oxyphyllae 7 ~ 20 parts, Semen Cuscutae 12 ~ 25 parts, Bulbus Fritillariae Ussuriensis 16 ~ 38 parts, Fructus Forsythiae 13 ~ 30 parts, Peng Lai Pueraria lobota 12 ~ 31 parts, Herba Adenosmae Glutinosi 13 ~ 28 parts, Rhizoma Polygonati Odorati 14 ~ 28 parts and 12 ~ 35 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 12 ~ 23 parts, Cortex Cinnamomi 15 ~ 25 parts, Radix Rehmanniae 16 ~ 31 parts, Carapax Trionycis 15 ~ 24 parts, Herba Artemisiae Annuae 15 ~ 26 parts, Rhizoma Dioscoreae 14 ~ 30 parts, Hippopus hippopus (Linnaeus) 13 ~ 20 parts, Rhizoma Belamcandae 14 ~ 24 parts, Fructus Aurantii Immaturus 11 ~ 21 parts, Radix Fissistigmatis Oldhamii 16 ~ 34 parts, Radix Et Rhizoma Nardostachyos 14 ~ 22 parts, Herba saussureae nigrescentis 12 ~ 30 parts, Aspongopus 15 ~ 28 parts, Climbing Viloet Herb 16 ~ 35 parts, Semen Canavaliae 14 ~ 25 parts, Diplazium lanceum (Thunb) 12 ~ 21 parts, Herba Eupatorii 15 ~ 32 parts, Radix Bupleuri 13 ~ 21 parts, Semen Coicis 13 ~ 30 parts, dominoes Herba pteridii latiusculi 17 ~ 35 parts, Cortex Hibisci 15 ~ 30 parts, Medulla Junci 14 ~ 32 parts, Rhizoma Smilacis Chinensis 14 ~ 35 parts, Radix Et Caulis Acanthopanacis Senticosi 8 ~ 21 parts, Radix ceratostigmatis willemottiani 14 ~ 31 parts, Fructus Psoraleae 16 ~ 34 parts, Fructus Tamarindi Indicae 15 ~ 35 parts, Fructus Alpiniae Oxyphyllae 9 ~ 17 parts, Semen Cuscutae 14 ~ 23 parts, Bulbus Fritillariae Ussuriensis 18 ~ 32 parts, Fructus Forsythiae 15 ~ 27 parts, Peng Lai Pueraria lobota 14 ~ 30 parts, Herba Adenosmae Glutinosi 15 ~ 26 parts, Rhizoma Polygonati Odorati 15 ~ 20 parts and 13 ~ 31 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Cortex Cinnamomi 24 parts, Radix Rehmanniae 20 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 25 parts, Rhizoma Dioscoreae 28 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 18 parts, Fructus Aurantii Immaturus 11 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 20 parts, Herba saussureae nigrescentis 25 parts, Aspongopus 18 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 22 parts, Diplazium lanceum (Thunb) 12 parts, Herba Eupatorii 31 parts, Radix Bupleuri 18 parts, Semen Coicis 26 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 31 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 18 parts, Fructus Psoraleae 32 parts, Fructus Tamarindi Indicae 30 parts, Fructus Alpiniae Oxyphyllae 14 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 24 parts, Rhizoma Polygonati Odorati 16 parts and 30 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 22 parts, Cortex Cinnamomi 18 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 24 parts, Rhizoma Dioscoreae 30 parts, Hippopus hippopus (Linnaeus) 16 parts, Rhizoma Belamcandae 22 parts, Fructus Aurantii Immaturus 20 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 21 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 33 parts, Semen Canavaliae 16 parts, Diplazium lanceum (Thunb) 20 parts, Herba Eupatorii 32 parts, Radix Bupleuri 21 parts, Semen Coicis 18 parts, dominoes Herba pteridii latiusculi 32 parts, Cortex Hibisci 20 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 35 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, Radix ceratostigmatis willemottiani 30 parts, Fructus Psoraleae 24 parts, Fructus Tamarindi Indicae 32 parts, Fructus Alpiniae Oxyphyllae 13 parts, Semen Cuscutae 21 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 28 parts, Herba Adenosmae Glutinosi 25 parts, Rhizoma Polygonati Odorati 16 parts and 23 parts, the frontal bone tip.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Cortex Cinnamomi 25 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 23 parts, Herba Artemisiae Annuae 19 parts, Rhizoma Dioscoreae 17 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 21 parts, Fructus Aurantii Immaturus 13 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 16 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 20 parts, Diplazium lanceum (Thunb) 15 parts, Herba Eupatorii 32 parts, Radix Bupleuri 20 parts, Semen Coicis 15 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 31 parts, Rhizoma Smilacis Chinensis 19 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 15 parts, Fructus Psoraleae 33 parts, Fructus Tamarindi Indicae 35 parts, Fructus Alpiniae Oxyphyllae 12 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 24 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 23 parts, Rhizoma Polygonati Odorati 17 parts and 27 parts, the frontal bone tip.
Wherein, it is characterized in that, when the dosage form of described medicine is paster agent, its preparation method comprises the following steps:
The first step, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis and dominoes Herba pteridii latiusculi are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, general, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip mix in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 ~ 2 times of described medicine each raw medicinal material quality sum, the Colophonium of 1 ~ 2 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.
Wherein, when the dosage form of described medicine is enema, its preparation method comprises the following steps:
The first step, by Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the mixing of the frontal bone tip, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae and Bulbus Fritillariae Ussuriensis are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described drug enema agent finished product.
Wherein, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The agent of embodiment 1 paster
The manufacturing process of syrup of the present invention is: get Ilex purpurea Hassk.[I.chinensis Sims 150g, Cortex Cinnamomi 240g, Radix Rehmanniae 200g, Carapax Trionycis 170g, Herba Artemisiae Annuae 250g, , Rhizoma Dioscoreae 280g, Hippopus hippopus (Linnaeus) 130g, Rhizoma Belamcandae 180g, Fructus Aurantii Immaturus 110g, Radix Fissistigmatis Oldhamii 320g, Radix Et Rhizoma Nardostachyos 200g, Herba saussureae nigrescentis 250g, Aspongopus 180g, Climbing Viloet Herb 310g, Semen Canavaliae 220g, Diplazium lanceum (Thunb) 120g, Herba Eupatorii 310g, Radix Bupleuri 180g, Semen Coicis 260g, dominoes Herba pteridii latiusculi 330g, Cortex Hibisci 230g, Medulla Junci 190g, Rhizoma Smilacis Chinensis 310g, Radix Et Caulis Acanthopanacis Senticosi 100g, Radix ceratostigmatis willemottiani 180g, Fructus Psoraleae 320g, Fructus Tamarindi Indicae 300g, Fructus Alpiniae Oxyphyllae 140g, Semen Cuscutae 220g, Bulbus Fritillariae Ussuriensis 310g, Fructus Forsythiae 250g, Peng Lai Pueraria lobota 300g, Herba Adenosmae Glutinosi 240g, Rhizoma Polygonati Odorati 160g and frontal bone tip 300g,
The first step, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis and dominoes Herba pteridii latiusculi are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 95% of 5 times relative to the mixture quality obtained, reflux was extracted after 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, general, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip mix in described ratio, add and extract 1 time relative to the alcohol heating reflux of the determining alcohol 85% of 3 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 70 DEG C 60 DEG C, relative density is the mastic of 1.22, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 2 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, heating decoction 1 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 2 times of described medicine each raw medicinal material quality sum, the Colophonium of 2 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.
Embodiment 2 enema
Oral liquid manufacturing process of the present invention is: get Ilex purpurea Hassk.[I.chinensis Sims 220g, Cortex Cinnamomi 180g, Radix Rehmanniae 300g, Carapax Trionycis 170g, Herba Artemisiae Annuae 240g, Rhizoma Dioscoreae 300g, Hippopus hippopus (Linnaeus) 160g, Rhizoma Belamcandae 220g, Fructus Aurantii Immaturus 200g, Radix Fissistigmatis Oldhamii 320g, Radix Et Rhizoma Nardostachyos 210g, Herba saussureae nigrescentis 300g, Aspongopus 220g, Climbing Viloet Herb 330g, Semen Canavaliae 160g, Diplazium lanceum (Thunb) 200g, Herba Eupatorii 320g, Radix Bupleuri 210g, Semen Coicis 180g, dominoes Herba pteridii latiusculi 320g, Cortex Hibisci 200g, Medulla Junci 190g, Rhizoma Smilacis Chinensis 350g, Radix Et Caulis Acanthopanacis Senticosi 90g, Radix ceratostigmatis willemottiani 300g, Fructus Psoraleae 240g, Fructus Tamarindi Indicae 320g, Fructus Alpiniae Oxyphyllae 130g, Semen Cuscutae 210g, Bulbus Fritillariae Ussuriensis 310g, Fructus Forsythiae 250g, Peng Lai Pueraria lobota 280g, Herba Adenosmae Glutinosi 250g, Rhizoma Polygonati Odorati 160g and frontal bone tip 230g,
The first step, by Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the mixing of the frontal bone tip, add relative to mixture 3 times ~ 5 times amount determining alcohol be 60% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.31, for subsequent use;
Second step, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae and Bulbus Fritillariae Ussuriensis are mixed in proportion, add relative to mixture 5 times of water gagings, boil 3 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.28;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described drug enema agent finished product.
Embodiment 3 liniment
The manufacturing process of liniment of the present invention is: get Ilex purpurea Hassk.[I.chinensis Sims 140g, Cortex Cinnamomi 250g, Radix Rehmanniae 300g, Carapax Trionycis 230g, Herba Artemisiae Annuae 190g, Rhizoma Dioscoreae 170g, Hippopus hippopus (Linnaeus) 130g, Rhizoma Belamcandae 210g, Fructus Aurantii Immaturus 130g, Radix Fissistigmatis Oldhamii 320g, Radix Et Rhizoma Nardostachyos 160g, Herba saussureae nigrescentis 300g, Aspongopus 220g, Climbing Viloet Herb 310g, Semen Canavaliae 200g, Diplazium lanceum (Thunb) 150g, Herba Eupatorii 320g, Radix Bupleuri 200g, Semen Coicis 150g, dominoes Herba pteridii latiusculi 330g, Cortex Hibisci 230g, Medulla Junci 310g, Rhizoma Smilacis Chinensis 190g, Radix Et Caulis Acanthopanacis Senticosi 100g, Radix ceratostigmatis willemottiani 150g, Fructus Psoraleae 330g, Fructus Tamarindi Indicae 350g, Fructus Alpiniae Oxyphyllae 120g, Semen Cuscutae 220g, Bulbus Fritillariae Ussuriensis 310g, Fructus Forsythiae 240g, Peng Lai Pueraria lobota 300g, Herba Adenosmae Glutinosi 230g, Rhizoma Polygonati Odorati 170g and frontal bone tip 270g,
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 10 times amount soak by water 2 hours, and second time adds weight portion 7 times amount soak by water 2 hours, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Enema prepared by embodiments of the invention 2 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage enema LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: the liniment of the embodiment of the present invention 3 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Acute skin irritation is tested: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, according to the method for above-mentioned " acute dermal toxicity test ", the paster agent of getting the embodiment of the present invention 1 to be attached on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
Hypersensitive test: get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The liniment getting the embodiment of the present invention 3 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical data:
Case selection: fetch and come from the routine summer-heat impairing the lung gastric pattern disease of wean hotness infant of the court's Pediatric Clinic in October ,-2011 in July, 2,010 308, wherein man 147 example, female 161 example; 2 ~ 5 years old age, 3.7 years old mean age; 308 routine infants are divided into syrup treatment group, oral liquid treatment group, liniment treatment group and matched group at random, and each experimental group 77 people, each experimental group is at age, sex difference not statistically significant.
Diagnostic criteria:
The heating of febrile disease due to summer-heat pathogen infant many time in full summer, most infant betide 2-5 year; 1, body temperature: between 38 ~ 40 DEG C, can be and delay type, tension and relaxation type or irregular pattern of fever, persistent.Weather is warmmer, and body temperature is higher.Pyrogenic stage is 1 ~ 3 month, naturally declines when weather is felt nice and cool.2, polydipsia polyuria: though infant has sweat gland dysfunction, normal renal function, therefore polyuria, urine are clear and frequent, though urine volume is many like that not as diabetes insipidus, also can reach more than 20 times at diel, not containing protein, specific gravity of urine is everlasting less than 1.008; Because between tissue, moisture reduces, make salivation reduce and cause thirsty polydipsia, every day, drink amount can reach more than 3L.
3, hypohidrosis or lossless: scarcely perspire, only the head slightly perspiration when onset sometimes.
4, other situations: sick just generally all right, aobvious sickly complexion, or occasionally have dyspepsia or flu-like symptoms, but how not serious.Health check-up slightly in except hyperemia, there is no other positive signs except pharyngeal.Startle as seen during high heat, drowsiness, rare nervous system serious symptoms., there is chronic facies in then visible loss of appetite, pale, unable, dysphoria of becoming thin when temperature is not moved back lastingly.Except the lymphocyte percentage of some cases increases, laboratory examination results is many within normal range.
5, the course of disease: majority lasts 1 ~ 2 month, but be also 3 ~ 4 months, until depart from hot environment or after cool autumn days, heating and other symptoms disappear gradually.
6, generate heat persistent, temperature is higher, generates heat higher, thirst and drinking, xerocheilia, and scaly dry skin is scorching hot, lossless or antiperspirant is few, dysphoria, clear urine in large amounts, red tongue, yellow and thin fur, rapid pulse.Hope according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as summer-heat impairing the lung gastric pattern disease of wean hotness further.
Therapeutic Method: in medication therapy groups:
Paster agent treatment group: use paster agent prepared by the embodiment of the present invention 1, every day 2 times, sooner or later respectively once, often pasting is for 1 time 1 course for the treatment of;
Enema treatment group: use enema prepared by the embodiment of the present invention 2, every day 2 times, sooner or later respectively once, often using is for 1 time a course for the treatment of;
Liniment treatment group: use liniment prepared by the embodiment of the present invention 3, every day 2 times, sooner or later respectively once, often using is for 1 time a course for the treatment of.
Matched group: take HUOXIANG ZHENGQI JIAONANG, every day 2 times, sooner or later respectively once, and each 0.25g, often taking is for 1 time 1 course for the treatment of;
The standard of curative effect evaluation:
Whether a kind of Outcome measure Main Basis for the treatment of the medicine of summer-heat impairing the lung gastric pattern disease of wean hotness disappears in the symptom of summer-heat impairing the lung gastric pattern disease of wean hotness.Taking medicine 3 days is a course for the treatment of.Concrete curative effect divides following three grades: cure: the symptom of summer-heat impairing the lung gastric pattern disease of wean hotness all disappears; Effective: the symptom of summer-heat impairing the lung gastric pattern disease disappears substantially.Take a turn for the better: the symptom of summer-heat impairing the lung gastric pattern disease of wean hotness obviously reduces; Invalid: after 1 course for the treatment of of taking medicine, the symptom of summer-heat impairing the lung gastric pattern disease of wean hotness has no to disappear.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy summer-heat impairing the lung gastric pattern disease of wean hotness of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy summer-heat impairing the lung gastric pattern disease of wean hotness of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.
After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine
Group Number of cases Cure number Effective number Good revolution Invalid number Total effective rate (%)
Patch treatment group 77 34 37 6 0 100%
Enema treatment group 77 35 38 4 0 100%
Liniment treatment treatment group 77 33 35 8 1 98.7%
Matched group 77 15 20 27 15 80.5%
Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and improvement number and time comparative example (%)
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Paster agent treatment group 77 16(20.8%) 19(24.7%) 20(30%) 22(28.6%)
Enema treatment group 77 17(22.1%) 18(23.4%) 19(24.7%) 23(29.9%)
Liniment treatment group 76 16(21.1%) 18(23.7%) 20(26.3%) 22(28.9%)
Matched group 62 6(9.7%) 8(12.9%) 9(14.5%) 39(62.9%)
According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 230 examples of effective and improvement number and matched group is cured, the effective and 62 routine follow-up of patients 1 year half that takes a turn for the better, result is added up, in paster agent treatment group 77 example, healing 34 example and effective 37 examples are all without recurrence, 1 case relapsed in 6 examples of improvement, and relapse rate is 1.3%; In enema treatment group 77 example, 4 examples of healing 35 example, effective 38 examples, improvement are all without recurring, and relapse rate is 0%; Cure 33 examples in liniment treatment group 76 example without recurrence, 1 case relapsed in effective 35 examples, recur 2 examples in 8 examples of improvement, relapse rate is 3.9%; Matched group is cured, effective and improvement number 62 example, recurs 6 examples, recurs 8 examples in effective 20 routine patients, recur 11 examples, relapse rate 40.3% in 27 examples of improvement in 15 routine patients of healing; Above-mentioned recurrence refers to that patient outcomes reaches healing, effective or after taking a turn for the better, do not occur that heating is persistent at 1 year half septum reset of following up a case by regular visits to, xerocheilia, scaly dry skin is scorching hot, lossless, dysphoria, clear urine in large amounts, red tongue, yellow and thin fur, the situations such as rapid pulse.
Model case: Lee, male, 3 years old, generate heat persistent, temperature is higher, and generate heat higher, xerocheilia, scaly dry skin is scorching hot, and antiperspirant is few, dysphoria, clear urine in large amounts, red tongue, yellow and thin fur, rapid pulse.Hope through trial inspection and the traditional Chinese medical science, hear, ask, cut and be diagnosed as summer-heat impairing the lung gastric pattern disease of wean hotness further.Use the liniment of Medications Example 3 of the present invention, every day 2 times, sooner or later each once medication is cured for 1 time substantially, continues medication and cures for 2 times, follow up a case by regular visits to and do not recur for 4 months.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of summer-heat impairing the lung gastric pattern disease of wean hotness for one kind, it is characterized in that, comprise following raw medicinal material: Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip.
2. the medicine for the treatment of summer-heat impairing the lung gastric pattern disease of wean hotness according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 10 ~ 25 parts, Cortex Cinnamomi 13 ~ 27 parts, Radix Rehmanniae 15 ~ 34 parts, Carapax Trionycis 12 ~ 31 parts, Herba Artemisiae Annuae 14 ~ 36 parts, Rhizoma Dioscoreae 12 ~ 32 parts, Hippopus hippopus (Linnaeus) 10 ~ 20 parts, Rhizoma Belamcandae 12 ~ 26 parts, Fructus Aurantii Immaturus 10 ~ 24 parts, Radix Fissistigmatis Oldhamii 15 ~ 35 parts, Radix Et Rhizoma Nardostachyos 12 ~ 24 parts, Herba saussureae nigrescentis 11 ~ 31 parts, Aspongopus 13 ~ 30 parts, Climbing Viloet Herb 15 ~ 38 parts, Semen Canavaliae 12 ~ 26 parts, Diplazium lanceum (Thunb) 10 ~ 24 parts, Herba Eupatorii 14 ~ 35 parts, Radix Bupleuri 10 ~ 22 parts, Semen Coicis 11 ~ 31 parts, dominoes Herba pteridii latiusculi 16 ~ 37 parts, Cortex Hibisci 13 ~ 30 parts, Medulla Junci 13 ~ 34 parts, Rhizoma Smilacis Chinensis 13 ~ 36 parts, Radix Et Caulis Acanthopanacis Senticosi 7 ~ 22 parts, Radix ceratostigmatis willemottiani 12 ~ 33 parts, Fructus Psoraleae 15 ~ 37 parts, Fructus Tamarindi Indicae 10 ~ 35 parts, Fructus Alpiniae Oxyphyllae 7 ~ 20 parts, Semen Cuscutae 12 ~ 25 parts, Bulbus Fritillariae Ussuriensis 16 ~ 38 parts, Fructus Forsythiae 13 ~ 30 parts, Peng Lai Pueraria lobota 12 ~ 31 parts, Herba Adenosmae Glutinosi 13 ~ 28 parts, Rhizoma Polygonati Odorati 14 ~ 28 parts and 12 ~ 35 parts, the frontal bone tip.
3. the medicine for the treatment of summer-heat impairing the lung gastric pattern disease of wean hotness according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 12 ~ 23 parts, Cortex Cinnamomi 15 ~ 25 parts, Radix Rehmanniae 16 ~ 31 parts, Carapax Trionycis 15 ~ 24 parts, Herba Artemisiae Annuae 15 ~ 26 parts, Rhizoma Dioscoreae 14 ~ 30 parts, Hippopus hippopus (Linnaeus) 13 ~ 20 parts, Rhizoma Belamcandae 14 ~ 24 parts, Fructus Aurantii Immaturus 11 ~ 21 parts, Radix Fissistigmatis Oldhamii 16 ~ 34 parts, Radix Et Rhizoma Nardostachyos 14 ~ 22 parts, Herba saussureae nigrescentis 12 ~ 30 parts, Aspongopus 15 ~ 28 parts, Climbing Viloet Herb 16 ~ 35 parts, Semen Canavaliae 14 ~ 25 parts, Diplazium lanceum (Thunb) 12 ~ 21 parts, Herba Eupatorii 15 ~ 32 parts, Radix Bupleuri 13 ~ 21 parts, Semen Coicis 13 ~ 30 parts, dominoes Herba pteridii latiusculi 17 ~ 35 parts, Cortex Hibisci 15 ~ 30 parts, Medulla Junci 14 ~ 32 parts, Rhizoma Smilacis Chinensis 14 ~ 35 parts, Radix Et Caulis Acanthopanacis Senticosi 8 ~ 21 parts, Radix ceratostigmatis willemottiani 14 ~ 31 parts, Fructus Psoraleae 16 ~ 34 parts, Fructus Tamarindi Indicae 15 ~ 35 parts, Fructus Alpiniae Oxyphyllae 9 ~ 17 parts, Semen Cuscutae 14 ~ 23 parts, Bulbus Fritillariae Ussuriensis 18 ~ 32 parts, Fructus Forsythiae 15 ~ 27 parts, Peng Lai Pueraria lobota 14 ~ 30 parts, Herba Adenosmae Glutinosi 15 ~ 26 parts, Rhizoma Polygonati Odorati 15 ~ 20 parts and 13 ~ 31 parts, the frontal bone tip.
4. the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Cortex Cinnamomi 24 parts, Radix Rehmanniae 20 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 25 parts, Rhizoma Dioscoreae 28 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 18 parts, Fructus Aurantii Immaturus 11 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 20 parts, Herba saussureae nigrescentis 25 parts, Aspongopus 18 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 22 parts, Diplazium lanceum (Thunb) 12 parts, Herba Eupatorii 31 parts, Radix Bupleuri 18 parts, Semen Coicis 26 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 31 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 18 parts, Fructus Psoraleae 32 parts, Fructus Tamarindi Indicae 30 parts, Fructus Alpiniae Oxyphyllae 14 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 24 parts, Rhizoma Polygonati Odorati 16 parts and 30 parts, the frontal bone tip.
5. the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 22 parts, Cortex Cinnamomi 18 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 17 parts, Herba Artemisiae Annuae 24 parts, Rhizoma Dioscoreae 30 parts, Hippopus hippopus (Linnaeus) 16 parts, Rhizoma Belamcandae 22 parts, Fructus Aurantii Immaturus 20 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 21 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 33 parts, Semen Canavaliae 16 parts, Diplazium lanceum (Thunb) 20 parts, Herba Eupatorii 32 parts, Radix Bupleuri 21 parts, Semen Coicis 18 parts, dominoes Herba pteridii latiusculi 32 parts, Cortex Hibisci 20 parts, Medulla Junci 19 parts, Rhizoma Smilacis Chinensis 35 parts, Radix Et Caulis Acanthopanacis Senticosi 9 parts, Radix ceratostigmatis willemottiani 30 parts, Fructus Psoraleae 24 parts, Fructus Tamarindi Indicae 32 parts, Fructus Alpiniae Oxyphyllae 13 parts, Semen Cuscutae 21 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 25 parts, Peng Lai Pueraria lobota 28 parts, Herba Adenosmae Glutinosi 25 parts, Rhizoma Polygonati Odorati 16 parts and 23 parts, the frontal bone tip.
6. the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Ilex purpurea Hassk.[I.chinensis Sims 14 parts, Cortex Cinnamomi 25 parts, Radix Rehmanniae 30 parts, Carapax Trionycis 23 parts, Herba Artemisiae Annuae 19 parts, Rhizoma Dioscoreae 17 parts, Hippopus hippopus (Linnaeus) 13 parts, Rhizoma Belamcandae 21 parts, Fructus Aurantii Immaturus 13 parts, Radix Fissistigmatis Oldhamii 32 parts, Radix Et Rhizoma Nardostachyos 16 parts, Herba saussureae nigrescentis 30 parts, Aspongopus 22 parts, Climbing Viloet Herb 31 parts, Semen Canavaliae 20 parts, Diplazium lanceum (Thunb) 15 parts, Herba Eupatorii 32 parts, Radix Bupleuri 20 parts, Semen Coicis 15 parts, dominoes Herba pteridii latiusculi 33 parts, Cortex Hibisci 23 parts, Medulla Junci 31 parts, Rhizoma Smilacis Chinensis 19 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix ceratostigmatis willemottiani 15 parts, Fructus Psoraleae 33 parts, Fructus Tamarindi Indicae 35 parts, Fructus Alpiniae Oxyphyllae 12 parts, Semen Cuscutae 22 parts, Bulbus Fritillariae Ussuriensis 31 parts, Fructus Forsythiae 24 parts, Peng Lai Pueraria lobota 30 parts, Herba Adenosmae Glutinosi 23 parts, Rhizoma Polygonati Odorati 17 parts and 27 parts, the frontal bone tip.
7. the preparation method of the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is paster agent, its preparation method comprises the following steps:
The first step, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis and dominoes Herba pteridii latiusculi are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae, Bulbus Fritillariae Ussuriensis, Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the frontal bone tip are mixed in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 ~ 2 times of described medicine each raw medicinal material quality sum, the Colophonium of 1 ~ 2 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.
8. the preparation method of the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is enema, its preparation method comprises the following steps:
The first step, by Fructus Forsythiae, Peng Lai Pueraria lobota, Herba Adenosmae Glutinosi, Rhizoma Polygonati Odorati and the mixing of the frontal bone tip, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;
Second step, Ilex purpurea Hassk.[I.chinensis Sims, Cortex Cinnamomi, Radix Rehmanniae, Carapax Trionycis, Herba Artemisiae Annuae, Rhizoma Dioscoreae, Hippopus hippopus (Linnaeus), Rhizoma Belamcandae, Fructus Aurantii Immaturus, Radix Fissistigmatis Oldhamii, Radix Et Rhizoma Nardostachyos, Herba saussureae nigrescentis, Aspongopus, Climbing Viloet Herb, Semen Canavaliae, Diplazium lanceum (Thunb), Herba Eupatorii, Radix Bupleuri, Semen Coicis, dominoes Herba pteridii latiusculi, Cortex Hibisci, Medulla Junci, Rhizoma Smilacis Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix ceratostigmatis willemottiani, Fructus Psoraleae, Fructus Tamarindi Indicae, Fructus Alpiniae Oxyphyllae, Semen Cuscutae and Bulbus Fritillariae Ussuriensis are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;
3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described drug enema agent finished product.
9. the preparation method of the medicine of the treatment summer-heat impairing the lung gastric pattern disease of wean hotness according to any one of claim 1-6, it is characterized in that, when the dosage form of described medicine is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;
Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
CN201510118296.1A 2015-03-18 2015-03-18 Medicine for treating summerheat injuring lung and stomach summer fever in children and preparation method of medicine Withdrawn CN104667107A (en)

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