CN103830464A - Traditional Chinese medicine composition for treating apoplexy and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating apoplexy and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and discloses a traditional Chinese medicine composition for treating apoplexy. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 30 to 86 parts of gardenia jasminoides ellis, 38 to 95 parts of ligusticum wallichii, 31 to 69 parts of ossa draconis, 35 to 78 parts of astragalus membranaceus, 38 to 85 parts of radix rehmanniae praeparata, 29 to 58 parts of white paeony root, 20 to 40 parts of bloodsucker, 26 to 56 parts of the root of bidentate achyranthes, 23 to 49 parts of safflower carthamus, 22 to 54 parts of peach kernels, 10 to 31 parts of rhizoma arisaematis, 11 to 28 parts of buthus martensi karsch, 18 to 37 parts of prunella vulgaris, 16 to 32 parts of coptis chinensis, 17 to 33 parts of schisandra chinensis, 8 to 19 parts of the root bark of the peony tree, 6 to 12 parts of frankincense, 9 to 18 parts of lithospermum, 8 to 14 parts of white atractylodes rhizome and 9 to 18 parts of poria cocos. The traditional Chinese medicine composition has the functions of dispelling wind-evil and relieving pain, tonifying qi and raising yang, invigorating the circulation of blood and removing blood stasis, dispelling wind-evil and performing spasmolysis, eliminating dampness and reducing phlegm as well as calming nerves and relieving uneasiness of mind. According to the pharmacodynamics experiment and the clinical verification, the traditional Chinese medicine composition is good in apoplexy treatment effect and less in side effect; and the tolerance of a patient to the composition is good.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of apoplexy and preparation method thereof.
Background technology
Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly to faint, syncope, the distortion of commissure that occurs together, dysphonia and occur that hemiplegia is a class disease of cardinal symptom.Because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three large diseases that threaten human health.
Apoplexy is the card of deficiency in origin and excess in superficiality, is preponderance of either YIN or YANG at this, and mechanism of qi is disorderly contrary; Be designated as fire and wind stirring up each other, expectorant is turbid to be jammed, blood-stasis internal-depression.The common cause of disease has is worried angryly, on the scoop, or addiction to greasy and sweet foods, indulge in sensual pleasures tired, or daily life is careless etc.
The successive dynasties traditional Chinese medical science, taking etiology and pathogenesis theory as foundation, has accumulated many invaluable experiences for the treatment of apoplexy.Think that the morbidity of apoplexy is because of energy and blood of human body loss, venation inanition, defends admittedly outward, so that ailment said due to cold or exposure enters median nexus and causes.As " Medical Treasures of the Golden Chamber " thinks that " venation inanition, ailment said due to cold or exposure are taken advantage of a weak point in opponent's defence into human body." Song dynasty sternly with and point out: " Rong Wei mistake degree, space between skin and muscles inanition, pathogen is taken advantage of a weak point ".Propose to gold dollar epoch Liu's interchannel: the sudden and violent viewpoint of containing of heart-fire.Li Dongyuan thinks " healthy energy from empty ".Zhu Danxi is with due to " damp-phlegm heat-dissipating ".Three all emphasizes the pathogenetic intrinsic factor of apoplexy.Qing Dynasty's Wang Qingren is emphasized occuring as due to ' blood stasis due to qi deficiency ' of apoplexy, he points out in errors in Medicine Corrected " apoplexy and hemiplegia; hemianesthesia is to be caused by blood stasis due to qi deficiency; should be with blood circulation promoting and blood stasis dispelling for ", this viewpoint is praised highly jointly for many doctors after Qing Dynasty's Wang Qingren, uses modern age this rule for the treatment of to treat primary disease and sums up many good experiences.
In various reports in recent years, think, apoplexy have stasis blocking be suffer from, wind-phlegm blocks, the heat different reasons such as to hold back blood stasis, interior-deficiency be this, conventionally apoplexy is divided into clinically to three kinds of pattern of syndrome (1) Qi deficiency blood stasis type; (2) obstruction of collateral caused by windphlegm type; (3) excessive rising of liver-YANG, liver-kidney yin deficiency.Find no matter wind, fire, gas, the stagnant venation of stagnation of phlegm of stroke patient its pathogenesis, all can cause blood stasis, have document announcement: cerebral thrombosis is taking blood stasis due to qi deficiency person as many, and obstruction of collateral caused by windphlegm takes second place, and excessive rising of liver-YANG is taken second place again.And the sensible venation of blood circulation promoting and blood stasis dispelling is one of important method for the treatment of of apoplexy.
At present aspect the treatment of apoplexy, but there are a lot of insoluble difficult problems, for example unsatisfactory curative effect, side effect is large etc.
Summary of the invention
Not very desirable problem in order to solve current apoplexia disease treatment situation, the invention provides a kind of Chinese medicine composition that is used for the treatment of apoplexy and preparation method thereof.
The technical scheme that the present invention takes is:
The Chinese medicine composition that is used for the treatment of apoplexy of the present invention is made up of the raw material of following weight portion: SHANZHIZI 30-86, Rhizoma Chuanxiong 38-95, Os Draconis 31-69, Radix Astragali 35-78, Radix Rehmanniae Preparata 38-85, Radix Paeoniae Alba 29-58, Hirudo 20-40, Radix Achyranthis Bidentatae 26-56, Flos Carthami 23-49, Semen Persicae 22-54, Rhizoma Arisaematis 10-31, Scorpio 11-28, Spica Prunellae 18-37, Rhizoma Coptidis 16-32, Fructus Schisandrae Chinensis 17-33, Cortex Moutan 8-19, Olibanum 6-12, Radix Arnebiae (Radix Lithospermi) 9-18, Rhizoma Atractylodis Macrocephalae 8-14, Poria 9-18.
Find after deliberation in the time that the weight portion of Chinese medicine composition of the present invention is composed as follows, to there is better clinical efficacy: SHANZHIZI 41-73, Rhizoma Chuanxiong 45-82, Os Draconis 39-58, Radix Astragali 44-67, Radix Rehmanniae Preparata 46-79, Radix Paeoniae Alba 32-51, Hirudo 25-35, Radix Achyranthis Bidentatae 34-47, Flos Carthami 33-41, Semen Persicae 29-47, Rhizoma Arisaematis 13-25, Scorpio 15-25, Spica Prunellae 21-30, Rhizoma Coptidis 20-28, Fructus Schisandrae Chinensis 21-27, Cortex Moutan 12-16, Olibanum 8-10, Radix Arnebiae (Radix Lithospermi) 11-15, Rhizoma Atractylodis Macrocephalae 10-12, Poria 12-15.
As one of preferred technical scheme: Chinese medicine composition of the present invention is made up of the raw material of following weight portion: SHANZHIZI 41, Rhizoma Chuanxiong 82, Os Draconis 39, the Radix Astragali 67, Radix Rehmanniae Preparata 46, the Radix Paeoniae Alba 51, Hirudo 25, Radix Achyranthis Bidentatae 47, Flos Carthami 33, Semen Persicae 47, Rhizoma Arisaematis 13, Scorpio 25, Spica Prunellae 21, Rhizoma Coptidis 28, Fructus Schisandrae Chinensis 21, Cortex Moutan 16, Olibanum 8, Radix Arnebiae (Radix Lithospermi) 15, the Rhizoma Atractylodis Macrocephalae 10, Poria 15.
As two of preferred technical scheme: Chinese medicine composition of the present invention is made up of the raw material of following weight portion: SHANZHIZI 73, Rhizoma Chuanxiong 45, Os Draconis 58, the Radix Astragali 44, Radix Rehmanniae Preparata 79, the Radix Paeoniae Alba 32, Hirudo 35, Radix Achyranthis Bidentatae 34, Flos Carthami 41, Semen Persicae 29, Rhizoma Arisaematis 25, Scorpio 15, Spica Prunellae 30, Rhizoma Coptidis 20, Fructus Schisandrae Chinensis 27, Cortex Moutan 12, Olibanum 10, Radix Arnebiae (Radix Lithospermi) 11, the Rhizoma Atractylodis Macrocephalae 12, Poria 12.
As three of preferred technical scheme: Chinese medicine composition of the present invention is made up of the raw material of following weight portion: SHANZHIZI 52, Rhizoma Chuanxiong 61, Os Draconis 48, the Radix Astragali 52, Radix Rehmanniae Preparata 59, the Radix Paeoniae Alba 41, Hirudo 30, Radix Achyranthis Bidentatae 41, Flos Carthami 38, Semen Persicae 37, Rhizoma Arisaematis 19, Scorpio 20, Spica Prunellae 26, Rhizoma Coptidis 24, Fructus Schisandrae Chinensis 25, Cortex Moutan 14, Olibanum 9, Radix Arnebiae (Radix Lithospermi) 13, the Rhizoma Atractylodis Macrocephalae 11, Poria 13.
The dosage form of the Chinese medicine composition that is used for the treatment of apoplexy of the present invention is the watered pill.
The concrete steps of method of preparing Chinese medicine composition of the present invention are as follows:
(1) first take SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae by proportioning, then put into respectively Chinese medicine grinder and pulverize, after pulverizing, cross 100 mesh sieves, to be mixed to get fine drug powder for subsequent use;
(2) take Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis, Fructus Schisandrae Chinensis, Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria by proportioning, then add in abstraction reaction still, add dehydrated alcohol to carry out heating and refluxing extraction, extract twice, dehydrated alcohol addition is that 5-9 doubly measures for the first time, the reflux time is 2-5h, dehydrated alcohol addition is that 3-6 doubly measures for the second time, and the reflux time is 1-3h, merge extractive liquid,, filter, then filtrate is carried out to distilling under reduced pressure recovery ethanol wherein;
(3) distill completely, filtrate is heated concentrated, concentratedly obtain thick paste, in the time of 60 DEG C, relative density is 1.28-1.33;
(4) in the thick paste of preparing in step (3), add the fine drug powder of step (1), mix homogeneously, with water pill, dry at 70-80 DEG C, make the watered pill.
In step (2), preferably: dehydrated alcohol addition is 7 times of amounts for the first time, and the reflux time is 3h, and dehydrated alcohol addition is 4 times of amounts for the second time, and the reflux time is 2h.
The present invention, on the basis of differential diagnosis in tcm, according to the principles of formulating prescriptions of traditional Chinese medical science monarch, chooses SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali and Radix Rehmanniae Preparata as monarch drug; SHANZHIZI has heat clearing away, pathogenic fire purging, effect of removing heat from blood; Rhizoma Chuanxiong has circulation of qi promoting, effect of wind-expelling pain-stopping; It is relieving convulsion that Os Draconis have kidney tonifying, stops cloudy malaria, effect of removing dampness gas; The Radix Astragali has tonifying Qi and lifting yang, effect of strengthening superficial resistance to stop perspiration; Radix Rehmanniae Preparata has enriches blood moistly, and beneficial essence is filled out effect of marrow.
Choosing the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae is ministerial drug; The Radix Paeoniae Alba has the easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving, and yin fluid astringing is received effect of antiperspirant; Hirudo has removing blood stasis, effect of Tong Jing Xiao Disorder; Radix Achyranthis Bidentatae has dissipating blood stasis blood, effect of subduing inflammation; Flos Carthami has promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain; Semen Persicae has blood circulation promoting and blood stasis dispelling, effect of loosening bowel to relieve constipation.
Choosing Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis and Fructus Schisandrae Chinensis is adjuvant drug; Rhizoma Arisaematis has expelling wind to relieve convulsion, effect of drying dampness to eliminate phlegm; Scorpio has endogenous wind stopping spasmolytic, dispersing pathogen accumulation, effect of removing obstruction in the collateral to relieve pain; Spica Prunellae has effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis; Rhizoma Coptidis has heat clearing and damp drying, effect of eliminating fire and detoxication; Fructus Schisandrae Chinensis has astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives effect of antiperspirant.
Choose Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria for making medicine; Cortex Moutan has clearing away heat and cooling blood, effect of promoting blood circulation to remove blood stasis; Olibanum has regulating qi and activating blood, and analgesic therapy chases after malicious effect; Radix Arnebiae (Radix Lithospermi) has removing heat from blood, invigorates blood circulation, and effect of removing toxic substances rash; Poria has promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, effect of mind tranquilizing and the heart calming.
Said medicine is after combination, collaborative compatibility between each medical material, make medicine of the present invention there is wind-expelling pain-stopping, tonifying Qi and lifting yang, blood circulation promoting and blood stasis dispelling, expelling wind to relieve convulsion, effect of drying dampness to eliminate phlegm and mind tranquilizing and the heart calming, medicine of the present invention has good curative effect through pharmacodynamic experiment and clinical verification to apoplexy, and few side effects, and patient tolerability is good.
Detailed description of the invention
The following examples are to describe in further detail of the present invention.
Embodiment 1
1.1 raw material compositions (g):
SHANZHIZI 30, Rhizoma Chuanxiong 95, Os Draconis 31, the Radix Astragali 78, Radix Rehmanniae Preparata 38, the Radix Paeoniae Alba 58, Hirudo 20, Radix Achyranthis Bidentatae 56, Flos Carthami 23, Semen Persicae 54, Rhizoma Arisaematis 10, Scorpio 28, Spica Prunellae 18, Rhizoma Coptidis 32, Fructus Schisandrae Chinensis 17, Cortex Moutan 19, Olibanum 6, Radix Arnebiae (Radix Lithospermi) 18, the Rhizoma Atractylodis Macrocephalae 8, Poria 18.
1.2 preparation methoies:
(1) first take SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae by proportioning, then put into respectively Chinese medicine grinder and pulverize, after pulverizing, cross 100 mesh sieves, to be mixed to get fine drug powder for subsequent use;
(2) take Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis, Fructus Schisandrae Chinensis, Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria by proportioning, then add in abstraction reaction still, add dehydrated alcohol to carry out heating and refluxing extraction, extract twice, dehydrated alcohol addition is 5 times of amounts for the first time, the reflux time is 2h, dehydrated alcohol addition is 3 times of amounts for the second time, and the reflux time is 1h, merge extractive liquid,, filter, then filtrate is carried out to distilling under reduced pressure recovery ethanol wherein;
(3) distill completely, filtrate is heated concentrated, concentratedly obtain thick paste, in the time of 60 DEG C, relative density is 1.28;
(4) in the thick paste of preparing in step (3), add the fine drug powder of step (1), mix homogeneously, with water pill, dry at 70 DEG C, make the watered pill.
Every 10 heavy 1 gram of the watered pill of preparation.
Embodiment 2
2.1 raw material compositions (g):
SHANZHIZI 86, Rhizoma Chuanxiong 38, Os Draconis 69, the Radix Astragali 35, Radix Rehmanniae Preparata 85, the Radix Paeoniae Alba 29, Hirudo 40, Radix Achyranthis Bidentatae 26, Flos Carthami 49, Semen Persicae 22, Rhizoma Arisaematis 31, Scorpio 11, Spica Prunellae 37, Rhizoma Coptidis 16, Fructus Schisandrae Chinensis 33, Cortex Moutan 8, Olibanum 12, Radix Arnebiae (Radix Lithospermi) 9, the Rhizoma Atractylodis Macrocephalae 14, Poria 9.
2.2 preparation methoies:
(1) first take SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae by proportioning, then put into respectively Chinese medicine grinder and pulverize, after pulverizing, cross 100 mesh sieves, to be mixed to get fine drug powder for subsequent use;
(2) take Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis, Fructus Schisandrae Chinensis, Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria by proportioning, then add in abstraction reaction still, add dehydrated alcohol to carry out heating and refluxing extraction, extract twice, dehydrated alcohol addition is 9 times of amounts for the first time, the reflux time is 5h, dehydrated alcohol addition is 6 times of amounts for the second time, and the reflux time is 3h, merge extractive liquid,, filter, then filtrate is carried out to distilling under reduced pressure recovery ethanol wherein;
(3) distill completely, filtrate is heated concentrated, concentratedly obtain thick paste, in the time of 60 DEG C, relative density is 1.33;
(4) in the thick paste of preparing in step (3), add the fine drug powder of step (1), mix homogeneously, with water pill, dry at 80 DEG C, make the watered pill.
Every 10 heavy 1 gram of the watered pill of preparation.
Embodiment 3
3.1 raw material compositions (g):
SHANZHIZI 41, Rhizoma Chuanxiong 82, Os Draconis 39, the Radix Astragali 67, Radix Rehmanniae Preparata 46, the Radix Paeoniae Alba 51, Hirudo 25, Radix Achyranthis Bidentatae 47, Flos Carthami 33, Semen Persicae 47, Rhizoma Arisaematis 13, Scorpio 25, Spica Prunellae 21, Rhizoma Coptidis 28, Fructus Schisandrae Chinensis 21, Cortex Moutan 16, Olibanum 8, Radix Arnebiae (Radix Lithospermi) 15, the Rhizoma Atractylodis Macrocephalae 10, Poria 15.
3.2 preparation methoies:
(1) first take SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae by proportioning, then put into respectively Chinese medicine grinder and pulverize, after pulverizing, cross 100 mesh sieves, to be mixed to get fine drug powder for subsequent use;
(2) take Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis, Fructus Schisandrae Chinensis, Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria by proportioning, then add in abstraction reaction still, add dehydrated alcohol to carry out heating and refluxing extraction, extract twice, dehydrated alcohol addition is 7 amounts for the first time, the reflux time is 3, dehydrated alcohol addition is 4 amounts for the second time, and the reflux time is 2, merge extractive liquid,, filter, then filtrate is carried out to distilling under reduced pressure recovery ethanol wherein;
(3) distill completely, filtrate is heated concentrated, concentratedly obtain thick paste, in the time of 60 DEG C, relative density is 1.30
(4) in the thick paste of preparing in step (3), add the fine drug powder of step (1), mix homogeneously, with water pill, is dried at 75 times, makes the watered pill.
Every 10 heavy 1 gram of the watered pill of preparation.
Embodiment 4
4.1 raw material compositions (g):
SHANZHIZI 73, Rhizoma Chuanxiong 45, Os Draconis 58, the Radix Astragali 44, Radix Rehmanniae Preparata 79, the Radix Paeoniae Alba 32, Hirudo 35, Radix Achyranthis Bidentatae 34, Flos Carthami 41, Semen Persicae 29, Rhizoma Arisaematis 25, Scorpio 15, Spica Prunellae 30, Rhizoma Coptidis 20, Fructus Schisandrae Chinensis 27, Cortex Moutan 12, Olibanum 10, Radix Arnebiae (Radix Lithospermi) 11, the Rhizoma Atractylodis Macrocephalae 12, Poria 12.
4.2 preparation methoies:
Preparation method is with 3.2 of embodiment 3.
Embodiment 5
5.1 raw material compositions (g):
SHANZHIZI 52, Rhizoma Chuanxiong 61, Os Draconis 48, the Radix Astragali 52, Radix Rehmanniae Preparata 59, the Radix Paeoniae Alba 41, Hirudo 30, Radix Achyranthis Bidentatae 41, Flos Carthami 38, Semen Persicae 37, Rhizoma Arisaematis 19, Scorpio 20, Spica Prunellae 26, Rhizoma Coptidis 24, Fructus Schisandrae Chinensis 25, Cortex Moutan 14, Olibanum 9, Radix Arnebiae (Radix Lithospermi) 13, the Rhizoma Atractylodis Macrocephalae 11, Poria 13.
5.2 preparation methoies:
Preparation method is with 3.2 of embodiment 3.
Pharmacodynamic study
The therapeutical effect of 1 pair of rat cerebral ischemia
1.1 laboratory animal
Wistar rat, male and female dual-purpose, body weight 180-200g, is provided by Chinese medicine research institute animal center breeding field.1.2 experimental drug
The medicine watered pill prepared by the embodiment of the present invention 5; Restorative bolus with tremendous power, Shiyiting Pharmaceutical Factory, Harbin pharmaceutical Industry Group produces; Pentobarbital sodium, clever biological production is breathed out in Shanghai.
1.3 test method
60 rats are divided into sham operated rats (not modeling type) immediately, model group, restorative bolus with tremendous power group (6g/kg), medicine high dose group of the present invention (12g/Kg), middle dosage group (6g/Kg) and low dose group (3g/Kg).
To test pentobarbital sodium for rat (50mg/Kg) intraperitoneal anesthesia, then separate bilateral common carotid arteries, the stimulating electrode of BT87-2 type instrument for detecting internal thrombosis and temperature sensor are hooked on tremulous pulse, continue to stimulate blood vessel wall 7 minutes with 1.5mA unidirectional current, use variations in temperature and the thrombosis situation of temperature sensor monitors blood vessel surface simultaneously, after bilateral thrombosis to be formed, sew up wound.
Perform the operation and start administration rear next day, oral administration, once a day, continue 10 days, after two of last administrations as a child, rat is carried out to sacrificed by decapitation, win brain and bilateral carotid arteries place thrombosis, weigh thrombus weight and cutaneous horn weight, then by brain as for baking constant weight in 110 DEG C of baking boxs, calculate cerebral index and brain water content, experimental result is as described in Table 1.
Cerebral index=cutaneous horn weight/body weight × 100%
Brain water content=(cutaneous horn weight-brain stem weight)/cutaneous horn heavy × 100%
The impact of table 1 medicine of the present invention on rat cerebral ischemia
| Group | Size of animal | Thrombus weight (g) | Cerebral index (%) | Brain water content (%) |
| Sham operated rats | 10 | 0.000±0.000 | 0.612±0.043 | 79.236±0.432 |
| Model group | 10 | 0.018±0.005* | 0.634±0.038 | 81.624±0.761* |
| Restorative bolus with tremendous power group | 10 | 0.012±0.003* | 0.623±0.056* | 80.056±0.587 |
| Medicine high dose group of the present invention | 10 | 0.010±0.001 △ | 0.575±0.032 | 79.425±0.651 △ |
| Dosage group in medicine of the present invention | 10 | 0.011±0.002 | 0.586±0.040 △ | 79.287±0.542 |
| Medicine low dose group of the present invention | 10 | 0.011±0.002 △ | 0.591±0.032 | 79.562±0.367 △ |
* P<0.05 and sham operated rats comparison
△p<0.01 and model group comparison
As can be seen from Table 1: model group has obvious thrombosis compared with sham operated rats in common carotid artery, and restorative bolus with tremendous power group and medicine group of the present invention produce and have certain left and right that alleviates thrombus weight, and high dose group alleviates the most obvious.
Medicine of the present invention and model group comparison, brain water content obviously reduces, and shows that the edema that medicine of the present invention causes cerebral ischemia has significant protective effect.
2 impacts on rat platelet aggregation
2.1 on the coherent impact of normal rat platelet
2.1.1 laboratory animal
Wistar rat, male and female dual-purpose, body weight 180-200g, is provided by Chinese medicine research institute animal center breeding field.2.1.2 experimental drug
The medicine watered pill prepared by the embodiment of the present invention 5; Restorative bolus with tremendous power, Shiyiting Pharmaceutical Factory, Harbin pharmaceutical Industry Group produces; 3.8% sodium citrate, Yuan Ju bio tech ltd, Shanghai produces.
2.1.3 test method
35 rats are divided into 5 groups immediately, sham operated rats, restorative bolus with tremendous power group (6g/kg), medicine high dose group of the present invention (12g/Kg), middle dosage group (6g/Kg) and low dose group (3g/Kg).Oral administration, once a day, last administration is after 1 hour, abdominal aortic is got blood, with 3.8% sodium citrate anticoagulant, separates platelet rich plasma and platelet poor plasma, with the platelet aggregation of SPA-4 type, to measure platelet 3min maximum agglutination rate, result is as shown in table 2.
Table 2 medicine of the present invention is on the coherent impact of normal rat platelet
| Group | Size of animal | 3min maximum agglutination rate (%) |
| Sham operated rats | 7 | 74.6±14.68 |
| Restorative bolus with tremendous power group | 7 | 49.2±26.4 |
| Medicine high dose group of the present invention | 7 | 42.6±36.8* |
| Dosage group in medicine of the present invention | 7 | 48.9±26.3 |
| Medicine low dose group of the present invention | 7 | 49.6±26.8* |
* P<0.05 and sham operated rats contrast
As can be seen from Table 2: medicine of the present invention has obvious inhibitory action to normal rat platelet aggregation.
2.2 on the coherent impact of normal rat platelet
2.2.1 laboratory animal
Wistar rat, male and female dual-purpose, body weight 180-200g, is provided by Chinese medicine research institute animal center breeding field.
2.1.2 experimental drug
The medicine watered pill prepared by the embodiment of the present invention 5; Restorative bolus with tremendous power, Shiyiting Pharmaceutical Factory, Harbin pharmaceutical Industry Group produces; 3.8% sodium citrate, Yuan Ju bio tech ltd, Shanghai produces; Adrenalin hydrochloride injection, Xi'an profit monarch drug industry is produced.
2.2.3 test method
42 rats are divided into 6 groups immediately, sham operated rats, model group, restorative bolus with tremendous power group (6g/kg), medicine high dose group of the present invention (12g/Kg), middle dosage group (6g/Kg) and low dose group (3g/Kg).
Oral administration, once a day, takes medicine after 8 days, subcutaneous injection 0.1% epinephrine 0.1ml/ only, stimulate and cause after " congestion " state with frozen water, then oral administration 2 days, altogether administration 10 days, after last administration 1 hour, abdominal aortic is got blood, with 3.8% sodium citrate anticoagulant, separates platelet rich plasma and platelet poor plasma, with the platelet aggregation of SPA-4 type, to measure platelet 3min maximum agglutination rate, result is as shown in table 3.
The impact of table 3 medicine of the present invention on rat's blood stasis model platelet aggregation
| Group | Size of animal | 3min maximum agglutination rate (%) |
| Sham operated rats | 7 | 64.8±12.11 |
| Model group | 7 | 83.6±5.62△ |
| Restorative bolus with tremendous power group | 7 | 66.5±11.32* |
| Medicine high dose group of the present invention | 7 | 65.3±9.56* |
| Dosage group in medicine of the present invention | 7 | 67.1±6.89 |
| Medicine low dose group of the present invention | 7 | 49.6±26.8** |
△p<0.01 and sham operated rats contrast
*p<0.05 and model group contrast
*p<0.001 and model group contrast
Restorative bolus with tremendous power and medicine of the present invention all have the effect of anticoagulant as can be seen from Table 3.
Clinical efficacy
1.1 MethodsThe cases enrolled diagnostic criterias
Draft " apoplexy diagnosis efficacy assessment standard " (the trying) of formulation according to State Administration of Traditional Chinese Medicine's encephalopathy emergency case scientific research cooperative groups:
Primary symptom: hemiplegia, god know unconsciousness, and speech is stuttering puckery or in silence, hemiparesthesia, crooked mouth and tongue.
Inferior disease: headache, dizzy, pupil god changes, and drinking-water is sent out and is choked, order wink not partially, ataxia.
Acute onset, premorbid has inducement more, often has premonitory symptom.
Age of onset is many more than 40 years old.
Possess 2 more than primary symptom, or 2 diseases of 1 primary symptom, can make a definite diagnosis in conjunction with onset, inducement, premonitory symptom, age;
Do not possess above-mentioned condition, also can make a definite diagnosis in conjunction with imaging examination result.
1.2 exclusion standard
Get rid of gestation, women breast-feeding their children, allergic constitution; Get rid of severe cardiac dysfunction, psychotic.
1.3 physical data
All selected patients are divided into two groups at random, treatment group 98 examples, wherein male patient's 55 examples, female patient 43 examples; Age 45-78 year, 62 years old mean age, disease time 1 month-9 years, average 1.5 years; Matched group 100 examples, wherein male patient's 56 examples, female patient 44 examples, age 50-80 year, 63 years old mean age, disease time 2 months-8 years, average 1.4 years.
1.4 Therapeutic Method
1.4.1 treatment group is taken the watered pill prepared by the embodiment of the present invention 5, instructions of taking: oral, and every day twice, each 6 grams, to take half an hour after meal, warm water takes.
1.4.2 the oral nimodipine of matched group (Ni Daer), each 20mg, every day 3 times, the each 100mg of Aspirin enteric coatel tablets (Ao Jina) simultaneously, every day 1 time.
Treating the course for the treatment of is 12 weeks,, according to clinical manifestation, sign and symptom are made to accurate recording, and carefully its untoward reaction is recorded in inquiry.Observe weekly in 1-4 week 1 time, every 2 weeks of week of 5-8 observes 1 time, and every 2 weeks of week of 9-12 observes 1 time.
1.5 lab testing
Before and after checking hepatic and renal function, blood fat, blood glucose, Hemorheology analysis, hematuria conventional therapy, respectively look into 1 time.
1.6 clinical efficacy score basis
Suffering limb muscular strength situation: 0 to be divided into muscular strength normal, 1 to be divided into muscular strength be 4 grades, and 2 are divided into 3 grades of muscular strengths, and 3 are divided into muscular strength below 2 grades.Divide according to the fluent degree of patient's language: 3 points of agraphias; Ambiguous 2 points of aphasia; 1 point of dysphonia; Dysphonia, but express clearly 0 point.Total mark is: muscular strength scoring adds language scoring.
The integration of illness for the treatment of group and matched group is more as shown in table 4.
The integration of illness comparison of table 4 treatment group and matched group
P>0.05
1.7 curative effect determinate standard
Recovery from illness: after treatment, decline index is more than or equal to 0.8;
Effective: after treatment, decline index is more than or equal to 0.5;
Effective: after treatment, decline index is more than or equal to 0.3;
Invalid: after treatment, decline index is less than or equal to 0.
1.8 therapeutic outcome
Two groups of therapeutic outcomes are as shown in table 5.
Table 5 liang group therapeutic effect contrast
| Group | Number of cases | Recovery from illness | Effective | Effectively | Invalid |
| Treatment group | 98 | 29 | 41 | 20 | 8 |
| Matched group | 100 | 12 | 35 | 38 | 15 |
1.9 untoward reaction
In treatment group, there are 5 examples to occur the slight symptom of feeling sick, have a headache, but do not affect continual cure; In matched group, there are 12 examples to occur diarrhoea, dizzy symptom, wherein have 8 examples to abandon continual cure.
1.10 conclusion
From the above results, medicine of the present invention is obviously being better than nimodipine and aspirin aspect the curative effect for the treatment of apoplexy, and the adverse reaction rate of medicine of the present invention still less, and patient's compliance is better.
Although illustrated and described embodiments of the invention, for the ordinary skill in the art, be appreciated that without departing from the principles and spirit of the present invention and can carry out multiple variation, amendment, replacement and modification to these embodiment, scope of the present invention is limited by claims and equivalent thereof.
Claims (9)
1. a Chinese medicine composition that is used for the treatment of apoplexy, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion: SHANZHIZI 30-86, Rhizoma Chuanxiong 38-95, Os Draconis 31-69, Radix Astragali 35-78, Radix Rehmanniae Preparata 38-85, Radix Paeoniae Alba 29-58, Hirudo 20-40, Radix Achyranthis Bidentatae 26-56, Flos Carthami 23-49, Semen Persicae 22-54, Rhizoma Arisaematis 10-31, Scorpio 11-28, Spica Prunellae 18-37, Rhizoma Coptidis 16-32, Fructus Schisandrae Chinensis 17-33, Cortex Moutan 8-19, Olibanum 6-12, Radix Arnebiae (Radix Lithospermi) 9-18, Rhizoma Atractylodis Macrocephalae 8-14, Poria 9-18.
2. the Chinese medicine composition that is used for the treatment of apoplexy as claimed in claim 1, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion: SHANZHIZI 41-73, Rhizoma Chuanxiong 45-82, Os Draconis 39-58, Radix Astragali 44-67, Radix Rehmanniae Preparata 46-79, Radix Paeoniae Alba 32-51, Hirudo 25-35, Radix Achyranthis Bidentatae 34-47, Flos Carthami 33-41, Semen Persicae 29-47, Rhizoma Arisaematis 13-25, Scorpio 15-25, Spica Prunellae 21-30, Rhizoma Coptidis 20-28, Fructus Schisandrae Chinensis 21-27, Cortex Moutan 12-16, Olibanum 8-10, Radix Arnebiae (Radix Lithospermi) 11-15, Rhizoma Atractylodis Macrocephalae 10-12, Poria 12-15.
3. the Chinese medicine composition that is used for the treatment of apoplexy as claimed in claim 2, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion: SHANZHIZI 41, Rhizoma Chuanxiong 82, Os Draconis 39, the Radix Astragali 67, Radix Rehmanniae Preparata 46, the Radix Paeoniae Alba 51, Hirudo 25, Radix Achyranthis Bidentatae 47, Flos Carthami 33, Semen Persicae 47, Rhizoma Arisaematis 13, Scorpio 25, Spica Prunellae 21, Rhizoma Coptidis 28, Fructus Schisandrae Chinensis 21, Cortex Moutan 16, Olibanum 8, Radix Arnebiae (Radix Lithospermi) 15, the Rhizoma Atractylodis Macrocephalae 10, Poria 15.
4. the Chinese medicine composition that is used for the treatment of apoplexy as claimed in claim 3, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion: SHANZHIZI 73, Rhizoma Chuanxiong 45, Os Draconis 58, the Radix Astragali 44, Radix Rehmanniae Preparata 79, the Radix Paeoniae Alba 32, Hirudo 35, Radix Achyranthis Bidentatae 34, Flos Carthami 41, Semen Persicae 29, Rhizoma Arisaematis 25, Scorpio 15, Spica Prunellae 30, Rhizoma Coptidis 20, Fructus Schisandrae Chinensis 27, Cortex Moutan 12, Olibanum 10, Radix Arnebiae (Radix Lithospermi) 11, the Rhizoma Atractylodis Macrocephalae 12, Poria 12.
5. the Chinese medicine composition that is used for the treatment of apoplexy as claimed in claim 4, is characterized in that: described Chinese medicine composition is made up of the raw material of following weight portion: SHANZHIZI 52, Rhizoma Chuanxiong 61, Os Draconis 48, the Radix Astragali 52, Radix Rehmanniae Preparata 59, the Radix Paeoniae Alba 41, Hirudo 30, Radix Achyranthis Bidentatae 41, Flos Carthami 38, Semen Persicae 37, Rhizoma Arisaematis 19, Scorpio 20, Spica Prunellae 26, Rhizoma Coptidis 24, Fructus Schisandrae Chinensis 25, Cortex Moutan 14, Olibanum 9, Radix Arnebiae (Radix Lithospermi) 13, the Rhizoma Atractylodis Macrocephalae 11, Poria 13.
6. the Chinese medicine composition that is used for the treatment of apoplexy as described in claim 1-5, is characterized in that: the dosage form of described Chinese medicine composition is the watered pill.
7. a method of preparing the Chinese medicine composition as described in claim 1-6, is characterized in that: the concrete steps of described method are as follows:
(1) first take SHANZHIZI, Rhizoma Chuanxiong, Os Draconis, the Radix Astragali, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Hirudo, Radix Achyranthis Bidentatae, Flos Carthami and Semen Persicae by proportioning, then put into respectively Chinese medicine grinder and pulverize, after pulverizing, cross 100 mesh sieves, to be mixed to get fine drug powder for subsequent use;
(2) take Rhizoma Arisaematis, Scorpio, Spica Prunellae, Rhizoma Coptidis, Fructus Schisandrae Chinensis, Cortex Moutan, Olibanum, Radix Arnebiae (Radix Lithospermi), the Rhizoma Atractylodis Macrocephalae and Poria by proportioning, then add in abstraction reaction still, add dehydrated alcohol to carry out heating and refluxing extraction, extract twice, dehydrated alcohol addition is that 5-9 doubly measures for the first time, the reflux time is 2-5h, dehydrated alcohol addition is that 3-6 doubly measures for the second time, and the reflux time is 1-3h, merge extractive liquid,, filter, then filtrate is carried out to distilling under reduced pressure recovery ethanol wherein;
(3) distill completely, filtrate is heated concentrated, concentratedly obtain thick paste, in the time of 60 DEG C, relative density is 1.28-1.33; (4) in the thick paste of preparing in step (3), add the fine drug powder of step (1), mix homogeneously, with water pill, dry at 70-80 DEG C, make the watered pill.
8. the method as described in claim 1-7, is characterized in that: in step (2), dehydrated alcohol addition is 7 times of amounts for the first time, and the reflux time is 3h, and dehydrated alcohol addition is 4 times of amounts for the second time, and the reflux time is 2h.
9. the purposes of the Chinese medicine composition as described in claim 1-6 any one in treatment apoplexy.
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| CN104147423A (en) * | 2014-08-26 | 2014-11-19 | 郝建 | Decoction for treating hand and foot numbness after stroke |
| CN113769014A (en) * | 2021-11-03 | 2021-12-10 | 广西中医药大学第一附属医院 | Traditional Chinese medicine composition for treating apoplexy and having effects of activating spleen, eliminating phlegm and dredging orifices and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113769014A (en) * | 2021-11-03 | 2021-12-10 | 广西中医药大学第一附属医院 | Traditional Chinese medicine composition for treating apoplexy and having effects of activating spleen, eliminating phlegm and dredging orifices and preparation method thereof |
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