CN106975030A - A kind of fermented tcm preparation and its preparation method and application - Google Patents

A kind of fermented tcm preparation and its preparation method and application Download PDF

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Publication number
CN106975030A
CN106975030A CN201710275242.5A CN201710275242A CN106975030A CN 106975030 A CN106975030 A CN 106975030A CN 201710275242 A CN201710275242 A CN 201710275242A CN 106975030 A CN106975030 A CN 106975030A
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Prior art keywords
parts
radix
chinese
root
preparation
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CN201710275242.5A
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Chinese (zh)
Inventor
李兴尧
李业明
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Individual
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Individual
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
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Abstract

The present invention relates to a kind of fermented tcm preparation, belong to the field of Chinese medicines, specifically a kind of fermented tcm preparation for treating diabetes, the invention further relates to the preparation method and application of said preparation, described fermented tcm preparation picks up the ears to account for 5% the 10% of Chinese medicine material mixing object amount will to pick up the ears in Chinese medicine material obtained by fermentation.The fermented tcm preparation that the present invention is provided, there is good effect in terms for the treatment of, healing diabetes, simultaneously, also there is good curative effect to the complication caused by diabetes, individually or other drugs can be coordinated to use for a long time, have no toxic side effect, have good effect to the recovery of physical function, compound method is simple to operate, can be mass produced.

Description

A kind of fermented tcm preparation and its preparation method and application
Technical field
The present invention relates to a kind of fermented tcm preparation, belong to the field of Chinese medicines, specifically one kind is using Chinese herbal medicine as raw material The fermented tcm preparation of preparation, the application the invention further relates to the preparation method of said preparation and in diabetes medicament.
Background technology
With the increasingly raising of living standards of the people, diabetes prevalence is just sharply increased, it has also become threaten human body One of principal disease of health.Diabetes be by different pathogeny (such as inherent cause, immunologic function disorder, microorganism infection and its Toxin, free radical, mental element etc.) cause a class metabolism disturbance syndrome of insulin definitely not enough or relative deficiency, mainly Including 1 type (T1DM) and 2 types (T2DM), wherein the most universal with T2DM.T1DM is a kind of autoimmune disease, it may be possible to due to Self immune system destruction is produced caused by the pancreatic islet p-cells of insulin.T1DM is multiple to be born in teenager.Patient is because of pancreas islet Plain acrinia is, it is necessary to rely on exogenous insulin supplement to sustain life.T2DM typical illness be polyuria, many drink diseases with And polyphagia.The ability that insulin is produced in T2DM bodies is not completely lost, and insulin is even produced excessively in some patients, but It is that the action effect of insulin is but had a greatly reduced quality, therefore the insulin in patient's body is a kind of relative lack.It is now recognized that T2DM Principal pathogenetic reason is insulin resistance (being mainly shown as hyperinsulinemia, the reduction of glucose utilization rate) and insulin secretion Not enough merging is present.
The diagnosis of diabetes is typically not difficult, and fasting blood-glucose is more than or equal to 7.0 mM/ls, and/or eats latter two hour Blood glucose, which is more than or equal to 11.1 mM/ls, to be made a definite diagnosis.
For pathogenesis of diabetes mellitus, the antidiabetic medicine of in the market main flow includes insulin and OHA two is big Class, T1DM is in default of caused by insulin, so needing to treat in the way of insulin injection.T2DM is primarily due to pancreas Caused by insulin resistance and the relative shortage of insulin, then (1) can be treated with agents by acting on pancreatic beta cell, is promoted Enter the sulfonylureas of insulin secretion, glinides and GLP-1 analogs；(2) by acting on dipeptidyl peptidase 4 (DPP4), suppress internal GLP-1 degraded, improve GLP-1 level, reach the DPP4 inhibitor of reduction blood glucose purpose；(3) lead to Cross and act on skeletal muscle, adipose tissue, improve the biguanides and Thiazolidinediones to insulin sensitivity；(4) By all kinds of α glucosidase inhibitors for acting on small intestine；(5) by suppressing re-absorbed sodium-Portugal of the kidney to glucose The grape sugar inhibitor of cotransporter 2.Above medicine is easy to produce drug resistance, and long-term, extensive application can be with liver, kidney work( Energy declines, ischemic disease, the symptom such as acute infection, enterogastric diseases, and therapeutic domain is narrow, and therapeutic effect is not thorough, controls Recurrence is easy to more afterwards, and relative cost is costly, and medicine time is long, is difficult to tackle the problem at its root.
Diabetes are to increase common incretion metabolism disease for Clinical symptoms with blood glucose, and traditional Chinese medicine is according to its clinical table Existing, system is classified as " quenching one's thirst " on a macro scale, by research in recent years, has to the mechanism of TCM Treatment of Diabetes and certain recognizes Know, traditional Chinese medicine can reduce blood by promoting insulin secretion, improving the approach such as insulin resistance, suppression glicentin secretion Sugar, by suppressing sugared reductase activity, suppressing protein non-enzyme glycosylation, promoting blood circulation and removing blood stasis, improvement microcirculation, improvement lipid metaboli etc. Effect preventing and treating chronic complicating diseases of diabetes, traditional Chinese medicine is prevented and treated diabetes and had a long history, and have accumulated abundant clinical experience, The science, method, prescription, drugs system for preventing and treating diabetes system is formd, with the unrivaled advantage of modern Western medicine.
The emphasis that the treatment of diabetes is always medically studied, because of the deficiency that the medicine researched and developed in doctor trained in Western medicine has in itself, The Chinese medicine preparation developed in the traditional Chinese medical science is particularly important, and is pursued a goal with determination in fundamentally treatment, healing diabetes.
The content of the invention
It is an object of the invention to provide a kind of fermented tcm preparation for treating diabetes, diabetes are cured mainly, while can treat The complication triggered by diabetes.
To achieve the above object, the technical solution adopted by the present invention is：
A kind of fermented tcm preparation：It will pick up the ears and Chinese medicine material mixed fermentation gained, the Chinese medicine material is by weight Meter：10-100 parts of Chinese cassia tree, 10-100 parts of dendrobium candidum, 10-100 parts of root of Chinese trichosanthes, 10-100 parts of rhizoma alismatis, 10-100 parts of the root of kudzu vine, pig 10-100 parts of Siberian cocklebur, 10-100 parts of Poria cocos, 10-100 parts of balsam pear, 10-100 parts of Chinese yam, 10-100 parts of the Radix Astragali, 6-60 parts of the wind-weed is yellow Smart 6-60 parts, 6-60 parts of oyster, 6-60 parts of Job's tears, 6-60 parts of peach kernel, 6-60 parts of radix scutellariae, 6-60 parts of earthworm is interior golden 6-60 parts, when Return 6-60 parts, 6-60 parts of radix glycyrrhizae, 4-40 parts of stiff silkworm, 4-40 parts of the bighead atractylodes rhizome, 4-40 parts of fructus garedeniae, 4-40 parts of motherwort, glutinous rehmannia 4-40 Part, 4-40 parts of the root bark of Chinese wolf-berry, 4-40 parts of HERBA EPIMEDII, golden cicada spends 4-40 parts, 2-20 parts of rheum officinale, 2-20 parts of golden cypress, 2-20 parts of rhizoma atractylodis, Tu Sub- 2-20 parts of silk, 2-20 parts of semen astragali complanati, 2-20 parts of Radix Codonopsis, 2-20 parts of Herba Lycopi, 2-20 parts of great burdock achene, 2-20 parts of the fruit of Chinese magnoliavine, jujube 2-20 parts, 2-20 parts of the coptis, 1-10 parts of leech, tuber of dwarf lilyturf 1-10 part, 1-10 parts of radix scrophulariae, 1-10 parts of the radix paeoniae rubrathe, 1-10 parts of radix pseudostellariae, ox 1-10 parts of knee, 1-10 parts of lucid asparagus, 1-10 parts of dark plum；Pick up the ears to account for the 5%-10% of Chinese medicine material medicine quality；
It is described to pick up the ears for Pleurotus sp., to be deposited in " Chinese microorganism strain preservation pipe on April 14th, 2014 Reason committee common micro-organisms center ", deposit number is CGMCC No.9060.
It is above-mentioned to pick up the ears in CN 105412739A (application number 201410480058.0, the applying date 2014 year 09 month 18) It is middle to announce.
Chinese medicine material of the present invention is counted by weight is preferably：50-100 parts of Chinese cassia tree, 50-100 parts of dendrobium candidum, root of Chinese trichosanthes 50-100 parts, 50-100 parts of rhizoma alismatis, 50-100 parts of the root of kudzu vine, 50-100 parts of umbellate pore furgus, 50-100 parts of Poria cocos, 50-100 parts of balsam pear, mountain 50-100 parts of medicine, 50-100 parts of the Radix Astragali, 30-60 parts of the wind-weed, 30-60 parts of sealwort, 30-60 parts of oyster, 30-60 parts of Job's tears, peach kernel 30-60 parts, 30-60 parts of radix scutellariae, 30-60 parts of earthworm is interior golden 30-60 parts, 30-60 parts of Radix Angelicae Sinensis, 30-60 parts of radix glycyrrhizae, stiff silkworm 20-40 Part, 20-40 parts of the bighead atractylodes rhizome, 20-40 parts of fructus garedeniae, 20-40 parts of motherwort, 20-40 parts of glutinous rehmannia, 20-40 parts of the root bark of Chinese wolf-berry, HERBA EPIMEDII 20-40 parts, golden cicada spends 20-40 parts, 10-20 parts of rheum officinale, 10-20 parts of golden cypress, 10-20 parts of rhizoma atractylodis, 10-20 parts of Semen Cuscutae, Sha Yuan Sub- 10-20 parts, 10-20 parts of Radix Codonopsis, 10-20 parts of Herba Lycopi, 10-20 parts of great burdock achene, 10-20 parts of the fruit of Chinese magnoliavine, 10-20 parts of jujube is yellow Connect 10-20 parts, 5-10 parts of leech, tuber of dwarf lilyturf 5-10 part, 5-10 parts of radix scrophulariae, 5-10 parts of the radix paeoniae rubrathe, 5-10 parts of radix pseudostellariae, root of bidentate achyranthes 5-10 Part, 5-10 parts of lucid asparagus, 5-10 parts of dark plum.
Chinese medicine material of the present invention is most preferably by weight：Chinese cassia tree 100g, dendrobium candidum 100g, root of Chinese trichosanthes 100g, rhizoma alismatis 100g, root of kudzu vine 100g, umbellate pore furgus 100g, Poria cocos 100g, balsam pear 100g, Chinese yam 100g, Radix Astragali 100g, wind-weed 60g, sealwort 60g are male Oyster 60g, Job's tears 60g, peach kernel 60g, radix scutellariae 60g, earthworm 60g, interior golden 60g, Radix Angelicae Sinensis 60g, radix glycyrrhizae 40g, stiff silkworm 40g, the bighead atractylodes rhizome 40g, fructus garedeniae 40g, motherwort 40g, glutinous rehmannia 40g, root bark of Chinese wolf-berry 40g, HERBA EPIMEDII 40g, golden cicada flower 40g, rheum officinale 40g, golden cypress 40g, rhizoma atractylodis 20g, Semen Cuscutae 20g, semen astragali complanati 20g, Radix Codonopsis 20g, Herba Lycopi 20g, great burdock achene 20g, fruit of Chinese magnoliavine 20g, jujube 20g, Coptis 10g, leech 10g, tuber of dwarf lilyturf 10g, radix scrophulariae 10g, radix paeoniae rubrathe 10g, radix pseudostellariae 10g, root of bidentate achyranthes 10g, lucid asparagus 10g, dark plum 10g.
The preparation method of the fermented tcm preparation is：
(1) count by weight, take 10-100 parts of Chinese cassia tree, 10-100 parts of dendrobium candidum, 10-100 parts of root of Chinese trichosanthes, rhizoma alismatis 10-100 parts, 10-100 parts of the root of kudzu vine, 10-100 parts of umbellate pore furgus, 10-100 parts of Poria cocos, 10-100 parts of balsam pear, 10-100 parts of Chinese yam is yellow 10-100 parts of stilbene, 6-60 parts of the wind-weed, 6-60 parts of sealwort, 6-60 parts of oyster, 6-60 parts of Job's tears, 6-60 parts of peach kernel, 6-60 parts of radix scutellariae, 6-60 parts of earthworm, interior golden 6-60 parts, 6-60 parts of Radix Angelicae Sinensis, 6-60 parts of radix glycyrrhizae, 4-40 parts of stiff silkworm, 4-40 parts of the bighead atractylodes rhizome, fructus garedeniae 4-40 Part, 4-40 parts of motherwort, 4-40 parts of glutinous rehmannia, 4-40 parts of the root bark of Chinese wolf-berry, 4-40 parts of HERBA EPIMEDII, 4-40 parts of golden cicada flower, 2-20 parts of rheum officinale, 2-20 parts of golden cypress, 2-20 parts of rhizoma atractylodis, 2-20 parts of Semen Cuscutae, 2-20 parts of semen astragali complanati, 2-20 parts of Radix Codonopsis, 2-20 parts of Herba Lycopi, great burdock achene 2-20 parts, 2-20 parts of the fruit of Chinese magnoliavine, 2-20 parts of jujube, 2-20 parts of the coptis, 1-10 parts of leech, tuber of dwarf lilyturf 1-10 part, 1-10 parts of radix scrophulariae is red 1-10 parts of Chinese herbaceous peony, 1-10 parts of radix pseudostellariae, 1-10 parts of the root of bidentate achyranthes, 1-10 parts of lucid asparagus, the Chinese medicine material mixing that 1-10 parts of dark plum, milling is extremely Mesh number is not more than 150 mesh, obtains Chinese medicine mixing fine powders, stand-by；
(2) take the Chinese medicine material mixture of step (1) and after mixed fermentation of picking up the ears, obtain fermentate, fermentate is dried, Wear into fine powder and obtain fermented tcm preparation；
The step (2) is picked up the ears the 5%-10% that inoculum concentration is Chinese medicine material, and temperature be 37-65 DEG C, humidity be Fermented 1-7 days under the conditions of 80%-98%, obtain fermented tcm preparation.
It is described to pick up the ears (Pleurotus sp.), it is deposited in " Chinese microorganism strain preservation pipe on April 14th, 2014 Reason committee common micro-organisms center ", deposit number is CGMCC No.9060.
Gained fermented tcm preparation can be made into powder, tablet, pill, capsule and pill, capsule, emulsion, syrup or oral liquid.
The application of the fermented tcm preparation：Application in treatment diabetes medicament.
The fermented tcm preparation of the present invention is the modern Chinese herbal medicine with reference to designed by the Chinese prescription principle of monarch.Using Bulk drug effect it is as follows：
Radix Codonopsis Dicotyledoneae, Campanulaceae, Radix Codonopsis has tonifying middle-Jiao and Qi, effect of strengthening spleen and tonifying lung.In summary, with party It is adjustment gastrointestinal motility function, antiulcer to join tonifying middle-Jiao and Qi, the pharmacological action of invigorating the spleen effect correlation.Enhancing body's immunity, Enhancing hematopoiesis function, resisting stress, cardiac stimulant, Hemorrhagic shock, regulation blood pressure, resist myocardial ischemia and suppresses platelet aggregation etc. act on.Party Ginseng also has the effect such as intelligence development, calmness, hypnosis, anticonvulsion, health.
The original perianth subclass of the coptis, grass of meadow rue subfamily, with the pharmacological activity such as antibacterial, antitumor and anti-arrhythmia, tool There are heat-clearing and damp-drying drug, purging intense heat and detonicating.Also there is antibacterial, hypoglycemic, antitumor, protection stomach lining isoreactivity.
Chinese cassia tree can trigger insulin signal transduction, the insulin receptor of autophosphorylation be activated, with similar insulin Effect.
Dendrobium candidum can not only strengthen insulin active, while blood sugar level can be significantly reduced, make blood normal；It can promote Circulation, expansion blood vessel, reduction cholesterolemia and triglyceride；The stem of noble dendrobium can both increase insulin secretion, can improve pancreas islet again Element resistance, for diabetic complications and complication, the normal complicated hypertension of diabetes, high fat of blood, the composition of the stem of noble dendrobium help to change The pathology of kind hypertension and high fat of blood, so as to adjust blood pressure and blood fat.For diabetes complicated cataract, the benefit of the stem of noble dendrobium is taken Except the blood sugar reducing function of the stem of noble dendrobium in itself, it can mainly be led with anti-cataract, the effect of stem of noble dendrobium anti-cataract by reducing hyperglycaemia The multiple pathological products caused are to lenticular infringement.
Medicine Waterplantain Alismataceae, Monocotyledonae, Angiospermae, modern medicine study, it is total that rhizoma alismatis can reduce serum Cholesterol and triacylglycerol content, slow down atherogenesis；Rhizoma alismatis and its preparation modern times are additionally operable to treat interior Ménière Disease, dyslipidemia, seminal emission, fatty liver and diabetes etc..
Root of Chinese trichosanthes nickname radices trichosanthis, belongs to and contains a certain amount of protein in Curcurbitaceae, radices trichosanthis：Trichosanthin.Root of Chinese trichosanthes Albumen (Trichosanthin) is effective protein of induction of labor in midpregnancy, while it also has anti-vesicular mole active and anti-Chinese mugwort Grow the activity of sick (AIDS)；Protein Karasurin has strong induced abortion to act on to pregnant mouse；Protein alpha-Momorcharin There is induced labor, immunosupress and antitumor action with β-Momorcharin.Still isolate the albumen being made up of 289 amino acid Matter α-Trichosanthin, cytotoxic protein Trichosanthin-ZG and polypeptide with trypsin inhibition activity etc.. Containing saccharide compound it is THFPS in radices trichosanthis, has obvious immunoregulation effect, immunocompetence can be strengthened, with aobvious The antitumor and cytotoxic activity write.Polysaccharide is main by glucose, galactolipin, fructose, mannose, xylose and a small amount of protein group Into.5 radices trichosanthis glycan (Trichosan) A, B, C, D, E with hypoglycemic activity are isolated from radices trichosanthis water extract.
Chinese cassia tree in above-mentioned Chinese medicine, dendrobium candidum, root of Chinese trichosanthes, rhizoma alismatis, the root of kudzu vine, umbellate pore furgus, Poria cocos, balsam pear, Chinese yam, Radix Astragali conduct Main ingredient, other drugs are used as adjuvant；Main ingredient and adjuvant mixing can more effectively improve the effect of respective composition；Simultaneously can be by adjuvant In each constituents according to 6:4:2:1 mass ratio mixing, i.e. adjuvant 1：Adjuvant 2：Adjuvant 3:Adjuvant 4 is 6:4:2:1, wherein auxiliary Medicine 1 is the wind-weed, sealwort, oyster, Job's tears, peach kernel, radix scutellariae, earthworm, interior gold, Radix Angelicae Sinensis, radix glycyrrhizae；Adjuvant 2 is stiff silkworm, the bighead atractylodes rhizome, mountain branch Son, motherwort, glutinous rehmannia, the root bark of Chinese wolf-berry, HERBA EPIMEDII, golden cicada flower 4-40；Adjuvant 3 be rheum officinale, golden cypress, rhizoma atractylodis, Semen Cuscutae, semen astragali complanati, Radix Codonopsis, Herba Lycopi, great burdock achene, the fruit of Chinese magnoliavine, jujube, the coptis；Adjuvant 4 is leech, the tuber of dwarf lilyturf, radix scrophulariae, the radix paeoniae rubrathe, radix pseudostellariae, the root of bidentate achyranthes, Tianmen Winter, dark plum；By Chinese medicine according to 10:6:4:2:1 scientific compatibility ratio, can be effectively by the effect of complementing each other between each traditional Chinese medicine ingredients Play ultimate attainment, and then microorganism is fermented wherein again, gained fermentate is sent out drawing Chinese medicine after fermentation of picking up the ears simultaneously The benefit materials that ferment is produced can be preferably as treatment, the medicine of healing diabetes.
The beneficial effects of the present invention are:
1. invention formulation has a heat-clearing QI invigorating, nourishing yin and supplementing the kidney, the curative effect such as promoting blood circulation, for glycolipid metabolism and B cell The mechanism of action of function and other endocrine hormone functions, the curative effect developed is high, the plant hypoglycemic medicine having no toxic side effect.
2. the fermented tcm preparation for the treatment diabetes that the present invention is provided, has well in terms for the treatment of, healing diabetes Effect, meanwhile, also there is good curative effect to the complication caused by diabetes, while diabetes are treated, cure complication, Individually or other drugs can be coordinated to use for a long time, have good effect to the recovery of physical function, compound method is simple to operate, It can be mass produced.
3. the present invention is pure fermentative microorganism Chinese medicine preparation, without any toxicity and side effects, safe and reliable；In addition, the present invention after Hold on the basis of science of Chinese drug processing fermentation method, with reference to the fermentation technique of modern biological project, Chinese medicine is fermented using picking up the ears Processing, adds the curative effect and utilization rate of medicine.
Embodiment
Following examples are used to the present invention be described in further detail, but are not construed as limiting the invention, tool of the invention Volume data is only limitted to absolutely not these embodiments.
First, medicine preparation
Embodiment 1
1. number meter, takes Chinese cassia tree 100g, dendrobium candidum 100g, root of Chinese trichosanthes 100g, rhizoma alismatis 100g, root of kudzu vine 100g, pig by weight Siberian cocklebur 100g, Poria cocos 100g, balsam pear 100g, Chinese yam 100g, Radix Astragali 100g, wind-weed 60g, sealwort 60g, oyster 60g, Job's tears 60g, peach Benevolence 60g, radix scutellariae 60g, earthworm 60g, interior golden 60g, Radix Angelicae Sinensis 60g, radix glycyrrhizae 60g, stiff silkworm 40g, bighead atractylodes rhizome 40g, fructus garedeniae 40g, benefit are female Careless 40g, glutinous rehmannia 40g, root bark of Chinese wolf-berry 40g, HERBA EPIMEDII 40g, golden cicada flower 40g, rheum officinale 40g, golden cypress 40g, rhizoma atractylodis 20g, Semen Cuscutae 20g, semen astragali complanati 20g, Radix Codonopsis 20g, Herba Lycopi 20g, great burdock achene 20g, fruit of Chinese magnoliavine 20g, jujube 20g, coptis 20g, leech 10g, wheat Winter 10g, radix scrophulariae 10g, radix paeoniae rubrathe 10g, radix pseudostellariae 10g, root of bidentate achyranthes 10g, lucid asparagus 10g, dark plum 10g Chinese medicine material medicine, by Chinese medicine After bulk drug mixing, milling is not more than 150 mesh to mesh number, obtains Chinese medicine mixing fine powders, stand-by；
2. activation of picking up the ears：PDA solid mediums are connected to using oese picking mycelia of picking up the ears, 20 DEG C, culture 120 it is small When, obtain pure culture single bacterium colony of picking up the ears.
3. by above-mentioned activation pick up the ears be inoculated into step 1 Chinese medicine material, and temperature be 65 DEG C, humidity be 98% condition Lower fermentation 7 days, obtains tunning, and the picking up the ears of activation accounts for the 10% of Chinese medicine material quality.
4. above-mentioned tunning drying, crushing, cross 100 mesh sieves, gained fine powder is fermented tcm preparation.
It is described to pick up the ears (Pleurotus sp.), it is deposited in " Chinese microorganism strain preservation pipe on April 14th, 2014 Reason committee common micro-organisms center ", deposit number is CGMCCNo.9060, and depositary institution address is the Chaoyang District, Beijing City North Star The institute 3 of West Road 1.
Embodiment 2
1. count by weight, 50 parts of Chinese cassia tree is taken, 50 parts of dendrobium candidum, 50 parts of root of Chinese trichosanthes, 50 parts of rhizoma alismatis, 50 parts of the root of kudzu vine, 50 parts of umbellate pore furgus, 50 parts of Poria cocos, 50 parts of balsam pear, 50 parts of Chinese yam, 50 parts of the Radix Astragali, 30 parts of the wind-weed, 30 parts of sealwort, 30 parts of oyster, Job's tears 30 parts, 30 parts of peach kernel, 30 parts of radix scutellariae, 30 parts of earthworm, interior golden 30 parts, 30 parts of Radix Angelicae Sinensis, 30 parts of radix glycyrrhizae, 20 parts of stiff silkworm, 20 parts of the bighead atractylodes rhizome, 20 parts of fructus garedeniae, 20 parts of motherwort, 20 parts of glutinous rehmannia, 20 parts of the root bark of Chinese wolf-berry, 20 parts of HERBA EPIMEDII, golden cicada spends 20 parts, 20 parts of rheum officinale, golden cypress 20 parts, 10 parts of rhizoma atractylodis, 10 parts of Semen Cuscutae, 10 parts of semen astragali complanati, 10 parts of Radix Codonopsis, 10 parts of Herba Lycopi, 10 parts of great burdock achene, 10 parts of the fruit of Chinese magnoliavine, 10 parts of jujube, 10 parts of the coptis, 5 parts of leech, 5 parts of the tuber of dwarf lilyturf, 5 parts of radix scrophulariae, 5 parts of the radix paeoniae rubrathe, 5 parts of radix pseudostellariae, 5 parts of the root of bidentate achyranthes, lucid asparagus 5 Part, 5 parts of Chinese medicine material medicines of dark plum, after Chinese medicine material medicine is mixed, milling is not more than 150 mesh to mesh number, obtains Chinese medicine mixing thin Powder, it is stand-by；
2. activation of picking up the ears：PDA solid mediums are connected to using oese picking mycelia of picking up the ears, 30 DEG C, culture 100 it is small When, obtain pure culture single bacterium colony of picking up the ears.
3. by above-mentioned activation pick up the ears be inoculated into step 1 Chinese medicine material, and temperature be 60 DEG C, humidity be 90% condition Lower fermentation 7 days, obtains tunning, and the picking up the ears of activation accounts for the 8% of Chinese medicine material quality.
4. above-mentioned tunning drying, crushing, cross 100 mesh sieves, gained fine powder is fermented tcm preparation.
Embodiment 3
1. count by weight, 10 parts of Chinese cassia tree is taken, 10 parts of dendrobium candidum, 10 parts of root of Chinese trichosanthes, 10 parts of rhizoma alismatis, 10 parts of the root of kudzu vine, 10 parts of umbellate pore furgus, 10 parts of Poria cocos, 10 parts of balsam pear, 10 parts of Chinese yam, 10 parts of the Radix Astragali, 6 parts of the wind-weed, 6 parts of sealwort, 6 parts of oyster, 6 parts of Job's tears, 6 parts of peach kernel, 6 parts of radix scutellariae, 6 parts of earthworm, interior golden 6 parts, 6 parts of Radix Angelicae Sinensis, 6 parts of radix glycyrrhizae, 4 parts of stiff silkworm, 4 parts of the bighead atractylodes rhizome, 4 parts of fructus garedeniae, benefit 4 parts of Brittle Falsepimpernel Herb, 4 parts of glutinous rehmannia, 4 parts of the root bark of Chinese wolf-berry, 4 parts of HERBA EPIMEDII, golden cicada spends 4 parts, 4 parts of rheum officinale, 4 parts of golden cypress, 2 parts of rhizoma atractylodis, Semen Cuscutae 2 Part, 2 parts of semen astragali complanati, 2 parts of Radix Codonopsis, 2 parts of Herba Lycopi, 2 parts of great burdock achene, 2 parts of the fruit of Chinese magnoliavine, 2 parts of jujube, 2 parts of the coptis, 1 part of leech, the tuber of dwarf lilyturf 1 part, 1 part of radix scrophulariae, 1 part of the radix paeoniae rubrathe, 1 part of radix pseudostellariae, 1 part of the root of bidentate achyranthes, 1 part of lucid asparagus, 1 part of Chinese medicine material medicine of dark plum, by Chinese medicine material After medicine mixing, milling is not more than 150 mesh to mesh number, obtains Chinese medicine mixing fine powders, stand-by；
2. activation of picking up the ears：PDA solid mediums are connected to using oese picking mycelia of picking up the ears, 35 DEG C, culture 100 it is small When, obtain pure culture single bacterium colony of picking up the ears.
3. by above-mentioned activation pick up the ears be inoculated into step 1 Chinese medicine material, and temperature be 60 DEG C, humidity be 80% condition Lower fermentation 7 days, obtains tunning.
4. above-mentioned tunning drying, crushing, cross 100 mesh sieves, gained fine powder is fermented tcm preparation.
2nd, clinical test
The diagnostic criteria of 1.1 diabetes：According to diagnostic criteria (1996 year) of the WHO about diabetes, fasting blood-glucose is more than Or equal to 7.0 mM/ls, and/or latter two hours blood glucose of eating can be made a definite diagnosis more than or equal to 11.1 mM/ls.
The clinical manifestation of 1.2 diabetes：Type 1 diabetes are multiple to be born in teenager, and onset is anxious, symptom substantially and again, on an empty stomach When insulin be less than 5 μ IU/ml；Diabetes B is more common in adult and the elderly, mostly soft-fat type, and onset is slow, symptom It is lighter.Performance symptom is generally " three-many-one-little ", 1. diuresis, after blood glucose rise, and substantial amounts of glucose is discharged from kidney, causes infiltration Property diuresis, therefore diuresis, daily urine volume can reach 2-10L；2. more drink, because of diuresis reason, and dehydration in body, so as to drink more； 3. more eat, because glucose can not be made full use of by body and be discharged with urine, cause that body heat source is not enough, patient is frequent Feel hungry, cause many foods；4. becoming thin, peripheral tissues increase glucose utilization disorders, fat, breaks down proteins, and metabolism is lost Weighing apparatus, thus patient gradually becomes thin, fatigue and weak, dehydration in addition, body weight substantially mitigates.
1.3 curative effect judging standard：Reference《New Chinese medicine is come personally research guideline》In criterion of therapeutical effect：
It is effective：Symptom integral reduce >=70%, FBG it is normal or decline more than 40%, HbAlc it is normal or decline 30% with On, TC, TG, LDL-C improvement is more than 30% or recovers normal；
Effectively：Symptom integral reduce >=30%, FBG it is normal or decline more than 20%, HbAlc it is normal or decline 10% with On, TC, TG, LDL-C make moderate progress before relatively treating, but not enough effective standard；
It is invalid：Clinical symptoms are unchanged or aggravate or improve degree less than 30%, and lab index is unchanged or raises.
Medicament application method：By the Chinese medicine preparation prepared of the present invention, bag/time of drug administration 1,3 times/day, after meal half an hour Plain boiled water takes, and 30 are a course for the treatment of, are followed the doctor's advice during treatment and suitably take exercise and keep on a diet, therapeutic effect such as table 1.
The therapeutic effect 2000 (example) of table 1
3rd, model case
Case 1
Mr. Wang, female is diagnosed as diabetes B for 73 years old, 4 years, shows as PVR, fundus hemorrhage, eyesight mould The symptom such as paste, pruitus, Asthenia and numbness, urgent urination, frequent micturition, palpitation and short breath, dysphoria, weak, fasting blood-glucose is 20mmol/L, glucose in urine (4+) is taken after three courses for the treatment of of this prescription agent, PVR, fundus hemorrhage, eye-blurred, skin scabies Itch, Asthenia and numbness, urgent urination, frequent micturition, palpitation and short breath, dysphoria, the symptom such as weak take a turn for the better, blood sugar urinary sugar checks normal, Continue to take to the 5th course for the treatment of and carry out after treatment, whole body pathology is wholly absent, and blood glucose is down to 7.0mmol, by six The treatment of year course for the treatment of, does not fall ill so far.
Case 2
Jiang, man, 65 years old, feels run-down, waist soreness disease symptoms are diagnosed as diabetes B through hospital, take a variety of control Medicine is treated, recurrent exerbation occurs in that the symptoms such as ice-cold, numb heart disease, trick, insomnia, pruitus, taken after this medicament Blood glucose, glucose in urine is basicly stable, continuously takes to after seven month, clinically shows that diabetes are returned to normal, syndrome Gradually take a turn for the better and disappear, withdrawn this medicine 1 year so far without recurrence.
Case 3
Certain is fought, man 58 years old, suffers from diabetes 6 years, blood glucose is between 10.6-17.8mmol/L, glucose in urine (5+), complication is The symptoms such as coronary disease lesion, pruitus, edema of lower extremity, hypopsia, change a variety of Chinese and western drugses during one's sickness, Relapse rate, With the trend of exacerbation, this medicament is taken two months, diabetes take a turn for the better, symptom mitigation, a 3rd month complication disappears substantially, continue Take normal to blood glucose after six month, stable half a year pays a return visit very normal.

Claims (7)

1. a kind of fermented tcm preparation, it is characterised in that：It will pick up the ears to press with Chinese medicine material mixed fermentation gained, the Chinese medicine material Parts by weight meter：10-100 parts of Chinese cassia tree, 10-100 parts of dendrobium candidum, 10-100 parts of root of Chinese trichosanthes, 10-100 parts of rhizoma alismatis, root of kudzu vine 10- 100 parts, 10-100 parts of umbellate pore furgus, 10-100 parts of Poria cocos, 10-100 parts of balsam pear, 10-100 parts of Chinese yam, 10-100 parts of the Radix Astragali, wind-weed 6- 60 parts, 6-60 parts of sealwort, 6-60 parts of oyster, 6-60 parts of Job's tears, 6-60 parts of peach kernel, 6-60 parts of radix scutellariae, 6-60 parts of earthworm, interior golden 6- 60 parts, 6-60 parts of Radix Angelicae Sinensis, 6-60 parts of radix glycyrrhizae, 4-40 parts of stiff silkworm, 4-40 parts of the bighead atractylodes rhizome, 4-40 parts of fructus garedeniae, 4-40 parts of motherwort, ground Yellow 4-40 parts, 4-40 parts of the root bark of Chinese wolf-berry, 4-40 parts of HERBA EPIMEDII, golden cicada spends 4-40 parts, 2-20 parts of rheum officinale, 2-20 parts of golden cypress, rhizoma atractylodis 2- 20 parts, 2-20 parts of Semen Cuscutae, 2-20 parts of semen astragali complanati, 2-20 parts of Radix Codonopsis, 2-20 parts of Herba Lycopi, 2-20 parts of great burdock achene, fruit of Chinese magnoliavine 2-20 Part, 2-20 parts of jujube, 2-20 parts of the coptis, 1-10 parts of leech, tuber of dwarf lilyturf 1-10 part, 1-10 parts of radix scrophulariae, 1-10 parts of the radix paeoniae rubrathe, radix pseudostellariae 1- 10 parts, 1-10 parts of the root of bidentate achyranthes, 1-10 parts of lucid asparagus, 1-10 parts of dark plum；Pick up the ears to account for the 5%-10% of Chinese medicine material medicine quality；
It is described to pick up the ears as Pleurotus sp., " Chinese microorganism strain preservation management committee is deposited on April 14th, 2014 Member's meeting common micro-organisms center ", deposit number is CGMCC No.9060.
2. according to the fermented tcm preparation described in claim 1, it is characterised in that：The Chinese medicine material is counted by weight：Meat Osmanthus 50-100 parts, 50-100 parts of dendrobium candidum, 50-100 parts of root of Chinese trichosanthes, 50-100 parts of rhizoma alismatis, 50-100 parts of the root of kudzu vine, umbellate pore furgus 50- 100 parts, 50-100 parts of Poria cocos, 50-100 parts of balsam pear, 50-100 parts of Chinese yam, 50-100 parts of the Radix Astragali, 30-60 parts of the wind-weed, sealwort 30- 60 parts, 30-60 parts of oyster, 30-60 parts of Job's tears, 30-60 parts of peach kernel, 30-60 parts of radix scutellariae, 30-60 parts of earthworm is interior golden 30-60 parts, 30-60 parts of Radix Angelicae Sinensis, 30-60 parts of radix glycyrrhizae, 20-40 parts of stiff silkworm, 20-40 parts of the bighead atractylodes rhizome, 20-40 parts of fructus garedeniae, 20-40 parts of motherwort, 20-40 parts of glutinous rehmannia, 20-40 parts of the root bark of Chinese wolf-berry, 20-40 parts of HERBA EPIMEDII, golden cicada spends 20-40 parts, 10-20 parts of rheum officinale, golden cypress 10-20 Part, 10-20 parts of rhizoma atractylodis, 10-20 parts of Semen Cuscutae, 10-20 parts of semen astragali complanati, 10-20 parts of Radix Codonopsis, 10-20 parts of Herba Lycopi, great burdock achene 10- 20 parts, 10-20 parts of the fruit of Chinese magnoliavine, 10-20 parts of jujube, 10-20 parts of the coptis, 5-10 parts of leech, tuber of dwarf lilyturf 5-10 part, 1-10 parts of radix scrophulariae, 5-10 parts of the radix paeoniae rubrathe, 5-10 parts of radix pseudostellariae, 5-10 parts of the root of bidentate achyranthes, 5-10 parts of lucid asparagus, 5-10 parts of dark plum.
3. according to the fermented tcm preparation described in claim 2, it is characterised in that：The Chinese medicine material is by weight：Chinese cassia tree 100g, dendrobium candidum 100g, root of Chinese trichosanthes 100g, rhizoma alismatis 100g, root of kudzu vine 100g, umbellate pore furgus 100g, Poria cocos 100g, balsam pear 100g, mountain Medicine 100g, Radix Astragali 100g, wind-weed 60g, sealwort 60g, oyster 60g, Job's tears 60g, peach kernel 60g, radix scutellariae 60g, earthworm 60g, interior gold 60g, Radix Angelicae Sinensis 60g, radix glycyrrhizae 40g, stiff silkworm 40g, bighead atractylodes rhizome 40g, fructus garedeniae 40g, motherwort 40g, glutinous rehmannia 40g, root bark of Chinese wolf-berry 40g, it is celestial Clever spleen 40g, golden cicada flower 40g, rheum officinale 40g, golden cypress 40g, rhizoma atractylodis 20g, Semen Cuscutae 20g, semen astragali complanati 20g, Radix Codonopsis 20g, Herba Lycopi 20g, great burdock achene 20g, fruit of Chinese magnoliavine 20g, jujube 20g, coptis 10g, leech 10g, tuber of dwarf lilyturf 10g, radix scrophulariae 10g, radix paeoniae rubrathe 10g, crown prince Join 10g, root of bidentate achyranthes 10g, lucid asparagus 10g, dark plum 10g.
4. a kind of preparation method of the fermented tcm preparation described in claim 1, it is characterised in that：
(1) count by weight, take 10-100 parts of Chinese cassia tree, 10-100 parts of dendrobium candidum, 10-100 parts of root of Chinese trichosanthes, rhizoma alismatis 10-100 Part, 10-100 parts of the root of kudzu vine, 10-100 parts of umbellate pore furgus, 10-100 parts of Poria cocos, 10-100 parts of balsam pear, 10-100 parts of Chinese yam, Radix Astragali 10- 100 parts, 6-60 parts of the wind-weed, 6-60 parts of sealwort, 6-60 parts of oyster, 6-60 parts of Job's tears, 6-60 parts of peach kernel, 6-60 parts of radix scutellariae, earthworm It is 6-60 parts, interior golden 6-60 parts, 6-60 parts of Radix Angelicae Sinensis, 6-60 parts of radix glycyrrhizae, 4-40 parts of stiff silkworm, 4-40 parts of the bighead atractylodes rhizome, 4-40 parts of fructus garedeniae, benefit 4-40 parts of Brittle Falsepimpernel Herb, 4-40 parts of glutinous rehmannia, 4-40 parts of the root bark of Chinese wolf-berry, 4-40 parts of HERBA EPIMEDII, golden cicada spends 4-40 parts, 2-20 parts of rheum officinale, golden cypress 2-20 parts, 2-20 parts of rhizoma atractylodis, 2-20 parts of Semen Cuscutae, 2-20 parts of semen astragali complanati, 2-20 parts of Radix Codonopsis, 2-20 parts of Herba Lycopi, great burdock achene 2-20 Part, 2-20 parts of the fruit of Chinese magnoliavine, 2-20 parts of jujube, 2-20 parts of the coptis, 1-10 parts of leech, tuber of dwarf lilyturf 1-10 part, 1-10 parts of radix scrophulariae, radix paeoniae rubrathe 1- 10 parts, 1-10 parts of radix pseudostellariae, 1-10 parts of the root of bidentate achyranthes, 1-10 parts of lucid asparagus, the Chinese medicine material mixing that 1-10 parts of dark plum, milling to mesh number No more than 150 mesh, obtain Chinese medicine mixing fine powders, stand-by；
(2) the Chinese medicine material mixture of step (1) is taken with after mixed fermentation of picking up the ears, obtaining fermentate, fermentate being dried, worn into Fine powder is to obtain fermented tcm preparation；
It is described to pick up the ears (Pleurotus sp.), " Chinese microorganism strain preservation management committee is deposited on April 14th, 2014 Member's meeting common micro-organisms center ", deposit number is CGMCC No.9060.
5. the preparation method as described in claim 4, it is characterised in that：The step (2) picks up the ears inoculum concentration for Chinese medicine material 5%-10%, and temperature be 37-65 DEG C, humidity be to ferment 1-7 days under the conditions of 80%-98%, obtain fermented tcm preparation.
6. the preparation method as described in claim 4, it is characterised in that：Final gained fermented tcm preparation can be made into powder, piece Agent, pill, capsule and pill, capsule, emulsion, syrup or oral liquid.
7. a kind of application of the fermented tcm preparation prepared described in claim 1 in treatment diabetes medicament.
CN201710275242.5A 2017-04-25 2017-04-25 A kind of fermented tcm preparation and its preparation method and application Pending CN106975030A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109090342A (en) * 2018-08-29 2018-12-28 成都乾坤动物药业股份有限公司 Fermented tcm additive and preparation method thereof and application method
CN111317808A (en) * 2020-03-04 2020-06-23 河南爱糖康健康科技股份有限公司 Hui drug enzyme for improving physique of diabetes patients

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274471A (en) * 2011-09-16 2011-12-14 姜元寿 Medicinal composition for treating diabetes
CN104606487A (en) * 2015-01-20 2015-05-13 李兴尧 Fermented traditional Chinese medicine preparation as well as preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102274471A (en) * 2011-09-16 2011-12-14 姜元寿 Medicinal composition for treating diabetes
CN104606487A (en) * 2015-01-20 2015-05-13 李兴尧 Fermented traditional Chinese medicine preparation as well as preparation method and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109090342A (en) * 2018-08-29 2018-12-28 成都乾坤动物药业股份有限公司 Fermented tcm additive and preparation method thereof and application method
CN111317808A (en) * 2020-03-04 2020-06-23 河南爱糖康健康科技股份有限公司 Hui drug enzyme for improving physique of diabetes patients

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