CN1234386C - Diabetes treating medicine and its preparation - Google Patents
Diabetes treating medicine and its preparation Download PDFInfo
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- CN1234386C CN1234386C CN 200310114009 CN200310114009A CN1234386C CN 1234386 C CN1234386 C CN 1234386C CN 200310114009 CN200310114009 CN 200310114009 CN 200310114009 A CN200310114009 A CN 200310114009A CN 1234386 C CN1234386 C CN 1234386C
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a diabetes treating medicine and a preparation method thereof. The diabetes treating medicine is a medicament which is prepared from traditional Chinese medicines as raw materials (portions by weight), such as 10 to 35 portions of wild balsam pear, 100 to 250 portions of kudzuvine root and 5 to 30 portions of semen litchi and both of or one kind of 1 to 100 portions of dodder and 5 to 30 portions of Chinese yam. The diabetes treating medicine has the preparation method that entirely or partly medicines are pulverized; the rest medicines are extracted by water to obtain extract; all the medicines are uniformly mixed, dried and pulverized to obtain a required preparation form. The present invention has the efficiency of quenching thirst, moistening dryness, clearing heat, promoting fluid, nourishing Yin, invigorating spleens and leveling three types of diabetes, has obviously therapeutic action and has an obvious function for reducing blood sugar. After treatment, triglyceride has a downward trend and excessive thirst, polydipsia, marasmus, adynamia, skin titillation, etc. are obviously improved. During medication, the diabetes treating medicine does not have any adverse reaction and has no side effect. Clinics and experiments show that the present invention is a safe and effective medicine for treating diabetes.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes, concrete is is a kind of medicine for the treatment of diabetes of feedstock production with the Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Technical background
Diabetes (diabetes mellitus) are that interior relative or absolute deficiency of insulin of a kind of body and target cell reduce insulin sensitivity, or there is structural defective in insulin itself and a kind of chronic disease of the carbohydrate, fat and the protein metabolism disorder that cause, and its main feature is hyperglycemia, glycosuria.For polydipsia, polyphagia, polyuria and lose weight (i.e. " three-many-one-little "), some tissues or organ generation morphosis are changed and dysfunction clinically, concurrent ketoacidosis, extremity gangrene, polyneuritis, lose one's sight and renal failure etc.Primary disease sickness rate benefit increases, and common, frequently-occurring disease has become international.
In Chinese medicine, diabetes are called quenches one's thirst.By theory of Chinese medical science quench one's thirst be meant because of eating and drinking without temperance and disorder of emotion etc. cause with polydipsia, polyphagia, polyuria, emaciated physique, or urinate pleasantly sweet for the disease of feature.Its pathological change mainly is that the deficiency of YIN is scorching.
Because diabetes cause of disease complexity is closely related with hereditary metabolism and living habit, therefore, at present this disease is only surveyed clinic control, and the life-time service of chemical medicine commonly used, regular meeting causes damage to patient's liver, kidney.Therefore, little from side effect, look for the Therapeutic Method of integration of edible and medicinal herbs in the Chinese medicine national medicine of security property, become the trend of current treating diabetes.
Summary of the invention
The objective of the invention is to propose a kind of medicine that diabetes is had the treatment diabetes of better therapeutical effect and safety.
Another object of the present invention provides the preparation method of the medicine of these treatment diabetes.
A kind of medicine for the treatment of diabetes of the present invention is.With following tcm components (weight portion), comprise the extract obtained medicament of making for raw material the Chinese medicine (weight portion) from following component: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30.The present invention also can add Semen Cuscutae 1-100, Rhizoma Dioscoreae 5-30 or one kind of.
The said dosage form of the present invention is that said dosage form is a said dosage form on any pharmaceutics, particularly oral tablet, granule, capsule, pill.
The preparation method of the medicine of treatment diabetes of the present invention is made up of following steps:
One, get Radix Puerariae, Semen Cuscutae decocts with water, or only all or part of Radix Puerariae is decocted with water filtration, concentrates, puts cold, adds ethanol, leaves standstill, and gets supernatant, filters, and reclaims ethanol and gets extractum, and is standby;
Two, remaining ingredient is ground into fine powder, sieve, and mixing, with (one) abundant mixing, required dosage form is made in dry, pulverizing.
The preparation method of the medicine of treatment diabetes of the present invention can also be made up of following steps:
Get wild Fructus Momordicae charantiae, Rhizoma Dioscoreae, Semen Litchi, be ground into fine powder, mix homogeneously is made required dosage form, also can add Radix Puerariae, Semen Cuscutae or one kind of, is ground into fine powder jointly, and mix homogeneously is made required dosage form.
Prescription of the present invention is based on Dai Nationality's medical science in the Chinese medicine to the understanding and the summary of experience of onset diabetes mechanism, sums up and forms with reference to modern medicine, pharmacological achievement in research, through repeatedly prescription experiment, meet the Chinese prescription rule, make a distinction between the important and the lesser one, tie in, each medicine complements each other in the preparation, make full side's generation effect, this prescription has to quench the thirst to be moisturized, clearing away heat and promoting production of body fluid, YIN nourishing spleen invigorating, calm down the effect of three types of diabetes, have the obvious treatment effect.According to 282 routine type ii diabetes patient clinical observations are shown: medicine of the present invention is 81% to the type ii diabetes total effective rate.Fasting glucose and 2 hours after the meal contrast blood glucose obviously reduce.Treatment back triglyceride has downward trend, to disease effects of having clear improvement such as excessive thirst polydipsia, unable, the skin itchings of becoming thin.Do not see any untoward reaction during the medication, have no side effect.Clinical and evidence the present invention is a kind of diabetes medicament for the treatment of safely and effectively.
Pharmacodynamics test of the present invention:
One, to acute toxicity test in mice
1, experiment material
Animal: mice, ICR body weight 18-20g, male and female half and half are provided by Kunming General Hospital Chengdu Military Area, the quality certification: No. (9703), the real moving word in Yunnan.
Medicine: this treatment diabetes medicament, the 0.5g/ grain is equivalent to raw material 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., and the suspension that is made into 13.33% (w/v) with water is for using.
Instrument: Kodak of Johnson ﹠ Johnson 750 type dry type biochemistry analyzer
2, experimental technique and result
20 of mices, male and female half and half with the Cmax 13.33% (w/v) of this treatment diabetes medicament, are pressed three gastric infusions in the maximum volume 40ml/kg one day, observe seven days continuously after the administration.20 mices all do not have dead after administration in seven days, and animal appearance, behavioral activity, the mental status, appetite, defecation and color thereof, fur, the colour of skin, breathing are all normal, the also no abnormal secretions in nose, eye, oral cavity, body weight increases to 22.30 ± 1.2g by 19.50 ± 0.5g.
3, conclusion
This treatment diabetes medicament toxicity is less, can not survey LD50, so measure its maximum tolerated dose.Maximum drug level with 13.33% (w/v), the maximum of 40ml/kg is irritated three gastric infusions in the stomach volume one day, the mice daily dose reaches 16g/kg (being equivalent to crude drug in whole 16g), is 320 times of clinical human dosage (3g/kg/d), and does not cause the animal toxicity reaction.This result shows that this treatment diabetes medicament toxicity is minimum, and is oral safer.
Two, to the rat long term toxicity test
1, experiment material
Animal: the SD rat, body weight 60-80g, male and female half and half provide the quality certification by Yunnan Province natural drug pharmacology key lab: No. the 9805th, the real moving card in Yunnan.
Medicine: this diabetes medicament, the 0.5g/ grain is equivalent to crude drug in whole 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., and the concentration that is made into 3.75%, 11.25%, 22.5% (w/v) with water is for using.
2, experimental technique and result
Get 80 of rats, be divided into 4 groups at random, 20 every group, male and female half and half.If blank group (C), feedwater, the basic, normal, high dosage group of this treatment diabetes medicament (L, M, H) is given this treatment diabetes medicinal liquid of basic, normal, high concentration respectively.4 treated animals all regularly are administered once by 20ml/kg (ig) every day, continuous 45 days, weigh weekly once, adjust dosage by body weight, 24h after the last administration, the eye socket rear vein beard is got blood and is made hematology and blood biochemical inspection (end-point method, performance rate method), get 10 animals (male and female each 5) and take off cervical vertebra and put to death and become celestial for every group then, calculate the heart, liver, spleen, lung, kidney organ's coefficient (g/100g body weight), and the heart, liver, spleen, lung, kidney, thyroid, thymus, adrenal gland, stomach and duodenum are done the pathology histological examination.All the other animal drug withdrawals continue breeding observing after two weeks, and the same method is put to death and become celestial, and calculate the acropetal coefficient and do the pathology histological examination.
3, conclusion
This treatment diabetes medicament gives rat with 0.75g/kg, 2.25g/kg and 4.5g/kg dosage (being equivalent to 10 times, 30 times and 60 times with dosage of the clinical day for human beings according to the weight) stomach, once a day, continuous 45 days, big mouse cage look on examine no abnormal, body weight gain is normal, hematology and blood biochemical are learned index, and the main organs coefficient is all in normal range.The high dose group rat heart, liver, spleen, lung, kidney, thyroid, thymus, adrenal gland, stomach and duodenum are done the pathology histological examination and are shown no obvious abnormalities.
Three, to the hypoglycemic activity of streptozotocin induced hyperglycemia mice
1, experiment material
Animal: mice, ICR body weight 20-22g, male, key lab provides the quality certification by the natural pharmacology in Yunnan Province: No. the 9806th, the real moving card in Yunnan.
Medicine: this treatment diabetes medicament, the 0.5g/ grain is equivalent to crude drug 2g, is provided by Yunnan Mingyang Pharmaceutical Co., Ltd., is made into 1.857%, 3.75% and 5.625% concentration confession usefulness with water.Diamicron, lot number 000620, the 80mg/ sheet, Tianjin Hua Jin pharmaceutical factory product is made into 0.2% concentration for using with water.Streptozotocin, lot number BA902, Sigma company provides.Face with preceding with 0.05ml/L, the acid of Chinese holly edge is made into 0.75% concentration for using.
Instrument: Kodak of Johnson ﹠ Johnson 750 type dry type biochemistry analyzer
2, experimental technique and result
Get 60 of mices, be divided into 6 groups at random, 10 every group, establish normal control (N), the basic, normal, high dosage group of this treatment of model control group (C) diabetes medicament (L, M, H), positive controls (S), N, C organize feedwater, and L, M, H group are given this treatment diabetes medicinal liquid of 1.875%, 3.75% and 5.625% respectively, S organizes to 0.2% diamicron medicinal liquid, each is organized all by 20ml/kg (ig) administration, once a day, and continuous 10 days.Administration the 8th day, N organizes to NS20ml/kg (ip), all the other 5 groups equal 0.75% streptozotocin solution 20ml/kg (ip), behind the 48h, the eye socket rear vein beard is got blood and is surveyed blood glucose value (enzyme process).
3, conclusion
The mouse blood sugar value that makes streptozotocin 0.15g/ (ip) obviously rises (P＜0.01), shows and causes hyperglycemia model.And give this treatment diabetes medicament 1.125g/kg the hyperglycemia mouse blood sugar is obviously descended (P＜0.05), show that this treatment diabetes medicament has hypoglycemic activity to the streptozotocin induced hyperglycemia mice.
The specific embodiment
Embodiment 1:
Get Radix Puerariae 140 gram, earlier Radix Puerariae 130 grams are decocted with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, extractum is standby; Get wild Fructus Momordicae charantiae 20 gram, Rhizoma Dioscoreae 5 grams, Semen Litchi 5 grams and be ground into fine powder, sieve with residue Radix Puerariae 10 grams, mixing, dry, pulverize with the abundant mixing of standby extractum, make tablet according to the conventional tablet preparation method.
Embodiment 2:
Get wild Fructus Momordicae charantiae 20 gram, Radix Puerariae 150 grams, Rhizoma Dioscoreae 30 grams, Semen Litchi 30 grams and be ground into fine powder, mix homogeneously, preparation technology makes tablet according to conventional tablet.
Embodiment 3:
Get Radix Puerariae 160 gram, earlier Radix Puerariae 145 grams are decocted with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, and extractum is standby; Get wild Fructus Momordicae charantiae 30 grams, Rhizoma Dioscoreae 7 grams, Semen Litchi 20 restrains with residue Radix Puerariae 15 grams and is ground into fine powder, sieve, and mixing, with the abundant mixing of standby extractum, dry, pulverizing is made granule according to the conventional tablet preparation method.
Embodiment 4:
Get wild Fructus Momordicae charantiae 30 grams, Radix Puerariae 160 grams, Rhizoma Dioscoreae 7 grams, Semen Litchi 15 grams, be ground into fine powder, mix homogeneously, preparation technology makes granule according to the conventional granulates agent.
Embodiment 5:
Get Radix Puerariae 155 grams, earlier Radix Puerariae 143 grams are decocted with water secondary, collecting decoction, filter, concentrate, put cold, add ethanol and make that to contain the alcohol amount be 60%, leave standstill, get supernatant, filter, reclaim ethanol, extractum is standby: get wild Fructus Momordicae charantiae 25 grams, Rhizoma Dioscoreae 10 grams, Semen Litchi 10 grams and residue Radix Puerariae 12 grams and be ground into fine powder, sieve, mixing is with the abundant mixing of standby extractum, dry, pulverizing are made capsule according to the conventional tablet preparation method.
Embodiment 6:
Get wild Fructus Momordicae charantiae 25 grams, Radix Puerariae 155 grams, Rhizoma Dioscoreae 10 grams, Semen Litchi 10 grams, be ground into fine powder, mix homogeneously is made capsule according to conventional capsule preparation technology.
Embodiment 7:
Get Radix Puerariae 130 gram, earlier with Radix Puerariae 122 grams, Semen Cuscutae 100 grams, decoct with water secondary, collecting decoction filters, concentrates, puts cold, adds ethanol and makes that to contain the alcohol amount be 60%, leaves standstill, and gets supernatant, filters, and reclaims ethanol, extractum is standby; Get wild Fructus Momordicae charantiae 15 gram, Rhizoma Dioscoreae 8 grams, Semen Litchi 8 grams and be ground into fine powder, sieve with residue Radix Puerariae 8 grams, mixing, dry, pulverize with the abundant mixing of standby extractum, make pill according to the conventional tablet preparation method.
Embodiment 8:
Get wild Fructus Momordicae charantiae 15 grams, Radix Puerariae 130 grams, Rhizoma Dioscoreae 8 grams, Semen Litchi 8 grams, Semen Cuscutae 40 grams, be ground into fine powder, mix homogeneously is made pill according to conventional pill preparation technology.
Claims (8)
1, a kind of medicine for the treatment of diabetes, its feature is being the medicament of being made by the raw material of following weight portion: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30.
2, a kind of medicine for the treatment of diabetes, its feature is being the medicament of being made by the raw material of following weight portion: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30, Semen Cuscutae 1-100.
3, a kind of medicine for the treatment of diabetes, its feature is being the medicament of being made by the raw material of following weight portion: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30, Rhizoma Dioscoreae 5-30.
4, a kind of medicine for the treatment of diabetes, its feature is being the medicament of being made by the raw material of following weight portion: wild Fructus Momordicae charantiae 10-35, Radix Puerariae 100-250, Semen Litchi 5-30, Semen Cuscutae 1-100, Rhizoma Dioscoreae 5-30.
5,, it is characterized in that said dosage form is oral tablet, granule, capsule or pill as the described a kind of medicine for the treatment of diabetes of claim 1-4.
6, as the described a kind of preparation method for the treatment of the medicine of diabetes of claim 1-4, it is characterized in that all raw material powders are broken into fine powder, mix homogeneously is made required dosage form.
7, as claim 1,3 described a kind of preparation methoies for the treatment of the medicine of diabetes, it is characterized in that forming by following steps:
One, get Radix Puerariae, decoct with water, filter, concentrate, put cold, add ethanol, leave standstill, get supernatant, filter, reclaim ethanol and get extractum, standby;
Two, surplus stock is ground into fine powder, sieve, and mixing, with (one) abundant mixing, required dosage form is made in dry, pulverizing.
8, as claim 2,4 described a kind of preparation methoies for the treatment of the medicine of diabetes, it is characterized in that forming by following steps:
One, get Radix Puerariae, Semen Cuscutae, decoct with water, filter, concentrate, put cold, add ethanol, leave standstill, get supernatant, filter, reclaim ethanol and get extractum, standby;
Two, surplus stock is ground into fine powder, sieve, and mixing, with (one) abundant mixing, required dosage form is made in dry, pulverizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310114009 CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310114009 CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541701A CN1541701A (en) | 2004-11-03 |
| CN1234386C true CN1234386C (en) | 2006-01-04 |
Family
ID=34337013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310114009 Expired - Lifetime CN1234386C (en) | 2003-11-06 | 2003-11-06 | Diabetes treating medicine and its preparation |
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| Country | Link |
|---|---|
| CN (1) | CN1234386C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211965A (en) * | 2013-03-28 | 2013-07-24 | 叶立新 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102512567A (en) * | 2011-12-27 | 2012-06-27 | 温先敏 | Dropping pill medicinal preparation for treating diabetes mellitus and preparation method |
| CN102626452A (en) * | 2012-04-25 | 2012-08-08 | 吴庆林 | Hawthorn, radix puerariae, gingko and balsam pear four-in-one flavone capsule |
| CN104873616B (en) * | 2015-05-27 | 2018-05-04 | 广西壮族自冶区中国科学院广西植物研究所 | Application of the litchi rind polyphenol in the medicine or health products that reduce liver tg is prepared |
| CN104873617B (en) * | 2015-05-27 | 2018-05-04 | 广西壮族自冶区中国科学院广西植物研究所 | Application of the litchi rind polyphenol in the medicine or health products that reduce liver low density lipoprotein cholesterol is prepared |
| CN108703282A (en) * | 2018-08-17 | 2018-10-26 | 陈文才 | A kind of wild bitter gourd sugar-reducing beverage and preparation method thereof |
-
2003
- 2003-11-06 CN CN 200310114009 patent/CN1234386C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103211965A (en) * | 2013-03-28 | 2013-07-24 | 叶立新 | Traditional Chinese medicine composition for treating diabetes and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1541701A (en) | 2004-11-03 |
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Effective date of registration: 20200817 Address after: 650200 Da Cun Xiao Changshan, osanqiao sub district office, Guandu District, Kunming City, Yunnan Province Patentee after: Yunnan Sunsail Pharmaceutical Co.,Ltd. Address before: 650051 Yunnan Province, Kunming city Beijing Road No. 152 building four floor. Patentee before: Wen Xianmin |
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Granted publication date: 20060104 |