CN1232291C - Medicine for treating diabetes - Google Patents
Medicine for treating diabetes Download PDFInfo
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- CN1232291C CN1232291C CN 200410013903 CN200410013903A CN1232291C CN 1232291 C CN1232291 C CN 1232291C CN 200410013903 CN200410013903 CN 200410013903 CN 200410013903 A CN200410013903 A CN 200410013903A CN 1232291 C CN1232291 C CN 1232291C
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Abstract
The present invention relates to a medicine for treating diabetes, which is a medicament prepared from raw materials with the following weight proportion: 10 to 15 shares of slenderstyle acanthopanax bark, 4 to 12 shares of giant knotweed, 10 to 15 shares of trumpetcreeper flower root, 10 to 20 shares of common yam rhizome, 8 to 12 shares of hairyvein agrimonia herb and bud and 8 to 12 shares of mulberry leaf. The present invention is mainly based on eliminating heat by nourishing yin, benefiting vital energy and detoxicating, activating blood flow and removing blood stasis, obtaining the action of lowering blood sugar and improving symptoms of patients. After the patients take the medicine, the blood sugar reducing effects are obvious; the medicine can not only have no toxic or side effects and pain, but also do not need to gradually increase dosage; after the blood sugar cuts down to the normal, the dosage can be halved, and the dosage of the patients is relieved. Accordingly, the medicine is suitable for long-term administration.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine, particularly a kind of medicine for the treatment of diabetes.
Background technology
Diabetes are that deficiency is caused because the absolute or relative interior branch of insulin oozes, and based on the systemic disease of carbohydrate metabolism disturbance, constitutional is many, and Secondary cases is few, and majority all belongs to autoimmune, gene cause.Though in early days how asymptomatic, polyuria, polydipsia, polyphagia and tired become thin etc. then occur to the clinical diabetes phase, and multiple complications such as blood vessel, nerve are arranged.Hypertension, diabetic cardiopathy, vision obstruction, edema numbness, skin pruritus, diabetic foot, uremia etc. appear.
What Western medicine was controlled diabetes has biguanides, a sulfonylurea drugs, but this type of medicine is not only to hepatic and kidney function obstacle person forbidding, and after medication some people anorexia can occur, feel sick, gastrointestinal reflection such as vomiting, even hepatic injury.Western medicine is since the invention insulin, blood sugar lowering quickly and accurately, the acute complications of diabetes obviously reduces, diabetes patient's survival rate obviously improves, but its chronic complicating diseases, as cardiovascular and cerebrovascular disease, nephropathy, neurological complication are along with the prolongation of patient's course of disease increases to some extent, caused blinding, disable, lethal harm becomes increasingly conspicuous, and this still do not had effective medicine and measure.Doctor trained in Western medicine thinks that primary disease need be taken medicine throughout one's life, and chemical synthetic drug is taken for a long time, certainly will damage Liver and kidney.
TCM treatment of diabetes, it is dialectical to be based on macroscopic view, whole function and holistic health level with the conditioning patient are criterion, can not think to be exactly simple blood sugar lowering, make a general survey of the successive dynasties name side that quenches one's thirst, respectively at different syndromes or Yin-nourishing and Yang-supporting, or invigorating the spleen and replenishing QI, or clear away heart-fire and hold up spleen or the lung moistening and production of body fluid promoting ... ... consolidate the effect of radically reforming to reach.At present, the Chinese medicine of treatment diabetes is a lot, but the usefulness side that has is improper, and the curative effect that has is not obvious.If any prescription in used Radix Codonopsis, Radix Scutellariae etc. to have the blood glucose increasing function Chinese medicine, see " national Chinese herbal medicine compilation " (People's Health Publisher) the 684th page, the 709th page, Radix Codonopsis is disclosed in the book, Radix Scutellariae has hyperglycemic function; Used Rhizoma Zingiberis in the prescription that has, and Rhizoma Zingiberis property is hot, the deficiency of YIN has hot person's forbidding, sees " the 67th page of newly organized Chinese herbal medicine handbook commonly used (Golden Shield publishing house).And the diabetics symptom is that the deficiency of YIN is scorching, the blood glucose height, more than each medicine should not the treatment diabetes medicine in use.As number of patent application is 03104755.6 Chinese patent, and it discloses a kind of Chinese medicine preparation of the diabetes of curing the disease, and hyperglycemic medicines such as Radix Codonopsis, Herba Dendrobii are wherein just arranged.
Summary of the invention
The technical problem to be solved in the present invention is at the deficiencies in the prior art, has proposed a kind of medicine of treatment diabetes of pure Chinese prescription, and main with replenishing YIN and removing heat, QI invigorating detoxifcation, promoting blood circulation to remove blood stasis, characteristics are to have no side effect, and are suitable for taking for a long time.
The technical problem to be solved in the present invention is achieved through the following technical solutions, and a kind of medicine for the treatment of diabetes is characterized in that it is the medicament of being made by the following weight proportion raw material:
Cortex Acanthopancis 10～15, Rhizoma Polygoni Cuspidati 4～12, Radix Campsis 10～15,
Rhizoma Dioscoreae 10～20, Herba Agrimoniae 8～12, Folium Mori 8～12.
The technical problem to be solved in the present invention is to come by the following technical programs to realize that further the best proportioning of crude drug of the present invention is:
Cortex Acanthopancis 10～12, Rhizoma Polygoni Cuspidati 4～6, Radix Campsis 10～12,
Rhizoma Dioscoreae 10～12, Herba Agrimoniae 8～10, Folium Mori 8～10.
The technical problem to be solved in the present invention is to come by the following technical programs to realize that further the best proportioning of crude drug of the present invention is:
Cortex Acanthopancis 10, Rhizoma Polygoni Cuspidati 5, Radix Campsis 10,
Rhizoma Dioscoreae 10, Herba Agrimoniae 10, Folium Mori 8.
The technical problem to be solved in the present invention is to come by the following technical programs further to realize, pharmaceutical dosage form of the present invention is for using the decoction that is decocted in water for oral dose.With being decocted in water for oral dose, every day, potion serviced once sooner or later.
The technical problem to be solved in the present invention is to come by the following technical programs to realize that further pharmaceutical dosage form of the present invention is an oral capsule, described material medicine cleaned, and high-temperature sterilization, dry back levigation incapsulates and gets final product.
Gradually being severe situation occurred frequently in China in the face of diabetes, summing up and the developing Chinese medicine medicine is treated the experience of diabetes, is our duty-bound duty, also is Chinese and western medicine people having a common goal and patient and his family's common aspiration.Chinese prescription of the present invention is that motherland's medical science " treatment must aim at the pathogenesis of disease " is main with benefiting QI and nourishing blood, promoting blood circulation to remove blood stasis, replenishing YIN and removing heat reaches blood sugar lowering, improve patient's symptom, after the patient took, hypoglycemic effect was obvious, both had no side effect, no pain, must progressively not increase dose again, and drop to still can reduce by half after normal at blood glucose and take, alleviate patient's dosage.
Pharmaceutical test:
One, animal acute toxicity experiment
Carry out acute toxicity test with mice and rat respectively, (5g crude drug/ml) irritate stomach (ig) medicament of the present invention three times on the one with maximum administration volume (mice 0.4ml/10g body weight, rat 2ml/100g body weight) is observed a week with Cmax.The result is none routine animal dead in experimentation, also there is not any toxic reaction, gastric infusion can not surveyed the median lethal dose(LD 50) (LD50) of this medicament, record three gastric infusion maximum tolerated doses (MTD) in a day, mice is 600g crude drug/kg, rat is 300g crude drug/kg, is equivalent to respectively be grown up intend 240 times and 120 times of clinical consumption per day.
Two, long-term toxicity test for animals
With the WISTAR rat medicament of the present invention is carried out long term toxicity test, divide high, medium and low three dosage (100g crude drug/kg, 30g crude drug/kg, 10g crude drug/kg, calculate by kg body weight, 40 times, 12 times, 4 times of clinical consumption per day are equivalent to respectively to be grown up), once a day, gastric infusion is 90 days continuously, continues after the drug withdrawal of part animal to see 14 days.Observe hematological indices, blood parameters through general situation, gross anatomy and histopathology are observed, and the result shows that the medication animal blood glucose obviously reduces (p＜0.05) than matched group, other non-evident sympton illustrates in the normal clinical scope of application it is safe.
Three, conclusion
This experimentation the present invention to blood glucose, blood glucose dosis tolerata with to the influence of serum insulin.Experimental result shows, medicament of the present invention can significantly reduce the blood sugar content of the hyperglycemia animal that normal mouse and chemical injury cause; And can obviously improve the plain resistance of mouse islets that spontaneous diabetic mice and hydrocortisone bring out, recover the sensitivity of body to insulin.
Clinical practice
For showing medicament of the present invention to the treatment of diabetes effect, with medicament of the present invention 260 routine diabeticss are carried out system's clinical observation, wherein I type 12 examples, II type 248 examples, its curative effect statistical result is as follows:
Table 1 clinical efficacy
Contrast before and after the table 2II type treating diabetes
| Project | Before the treatment | After the treatment | |||
| Symptom is arranged | Sx | No change | Sx | Effective percentage % | |
| Three-many-one-little | 248 | 248 | 0 | 0 | 100 |
| Blurred vision | 216 | 210 | 6 | 0 | 97.1 |
| Fatigue and weak | 248 | 246 | 2 | 0 | 99.1 |
| Constipation | 102 | 90 | 12 | 0 | 89.7 |
| Numb limbs and tense tendons | 163 | 158 | 5 | 0 | 90.3 |
| Blood glucose value | 248 | 241 | 7 | 0 | 91.5 |
Show that from above clinical statistics data this is to the control hyperglycemia, the many complication that alleviate the patient have obvious effects, are a kind of good medicine of treatment diabetes.
What take that medicament of the present invention must grasp is: after the blood glucose of taking medicine is reduced to normal value, still must take medicine, dose can reduce by half and take.
The specific embodiment
Embodiment 1: a kind of medicine for the treatment of diabetes comprises the following weight proportion raw material:
Cortex Acanthopancis 10, Rhizoma Polygoni Cuspidati 5, Radix Campsis 10,
Rhizoma Dioscoreae 10, Herba Agrimoniae 10, Folium Mori 8.
With being decocted in water for oral dose, every day, potion serviced once sooner or later.
Embodiment 2: a kind of medicine for the treatment of diabetes comprises the following weight proportion raw material:
Cortex Acanthopancis 12, Rhizoma Polygoni Cuspidati 6, Radix Campsis 10,
Rhizoma Dioscoreae 12, Herba Agrimoniae 10, Folium Mori 10.
With being decocted in water for oral dose, every day, potion serviced once sooner or later.
Embodiment 3: a kind of medicine for the treatment of diabetes comprises the following weight proportion raw material:
Cortex Acanthopancis 15, Rhizoma Polygoni Cuspidati 10, Radix Campsis 12,
Rhizoma Dioscoreae 20, Herba Agrimoniae 12, Folium Mori 8.
Described material medicine is cleaned, high-temperature sterilization, dry back levigation incapsulates and gets final product.But must be noted that by crude drug dosage and take.
Embodiment 4: a kind of medicine for the treatment of diabetes comprises the following weight proportion raw material:
Cortex Acanthopancis 10, Rhizoma Polygoni Cuspidati 4, Radix Campsis 10,
Rhizoma Dioscoreae 15, Herba Agrimoniae 10, Folium Mori 8.
Crude drug of the present invention also can refine into granule and use.
Claims (5)
1. medicine for the treatment of diabetes, it is characterized in that: it is the medicament of being made by the following weight proportion raw material
Cortex Acanthopancis 10～15, Rhizoma Polygoni Cuspidati 4～12, Radix Campsis 10～15,
Rhizoma Dioscoreae 10～20, Herba Agrimoniae 8～12, Folium Mori 8～12.
2. the medicine of treatment diabetes according to claim 1 is characterized in that: the proportioning of crude drug of the present invention is:
Cortex Acanthopancis 10～12, Rhizoma Polygoni Cuspidati 4～6, Radix Campsis 10～12,
Rhizoma Dioscoreae 10～12, Herba Agrimoniae 8～10, Folium Mori 8～10.
3. the medicine of treatment diabetes according to claim 1 is characterized in that: the proportioning of crude drug of the present invention is:
Cortex Acanthopancis 10, Rhizoma Polygoni Cuspidati 5, Radix Campsis 10,
Rhizoma Dioscoreae 10, Herba Agrimoniae 10, Folium Mori 8.
4. the medicine of treatment diabetes according to claim 1 is characterized in that: pharmaceutical dosage form of the present invention is for using the decoction that is decocted in water for oral dose.
5. the medicine of treatment diabetes according to claim 1 is characterized in that: pharmaceutical dosage form of the present invention is an oral capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410013903 CN1232291C (en) | 2004-01-12 | 2004-01-12 | Medicine for treating diabetes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410013903 CN1232291C (en) | 2004-01-12 | 2004-01-12 | Medicine for treating diabetes |
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| Publication Number | Publication Date |
|---|---|
| CN1555865A CN1555865A (en) | 2004-12-22 |
| CN1232291C true CN1232291C (en) | 2005-12-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410013903 Expired - Fee Related CN1232291C (en) | 2004-01-12 | 2004-01-12 | Medicine for treating diabetes |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100362988C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Chinese and western medicine composition contg. metformin |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100356943C (en) * | 2005-09-09 | 2007-12-26 | 上海大学 | Medicinal composition for treating diabetes |
| CN100381150C (en) * | 2006-09-01 | 2008-04-16 | 胡可丁 | Composition comprising epalrestat |
| CN100363000C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Chinese and western medicines composition contg. Avandia and its prepn. method |
| CN100362998C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Medicine composition for treating diabetes |
| CN101264203B (en) * | 2008-04-28 | 2010-06-23 | 汪甬伟 | Chinese and western medicine composition for treating diabetes |
| CN103041122B (en) * | 2013-01-22 | 2014-05-14 | 崔合芳 | Medicinal composition for improving sugar tolerance of impaired glucose tolerance (IGT) patient |
-
2004
- 2004-01-12 CN CN 200410013903 patent/CN1232291C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100362988C (en) * | 2006-09-01 | 2008-01-23 | 胡可丁 | Chinese and western medicine composition contg. metformin |
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| CN1555865A (en) | 2004-12-22 |
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