CN1943632A - A kind of medicine for treating infant cold and its preparing method - Google Patents
A kind of medicine for treating infant cold and its preparing method Download PDFInfo
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- CN1943632A CN1943632A CN 200610041371 CN200610041371A CN1943632A CN 1943632 A CN1943632 A CN 1943632A CN 200610041371 CN200610041371 CN 200610041371 CN 200610041371 A CN200610041371 A CN 200610041371A CN 1943632 A CN1943632 A CN 1943632A
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Abstract
This is a kind of medicine for treating infant cold. The medicine is prepared by using honeysuckle, forsythia suspensa Vahl, herba schizeneptae, mint, matricaria indica. Its preparing method is: firstly make the above raw materials into Chinese traditional medicinal decoction pieces, then add water to the honeysuckle, forsythia suspensa vahl, herba schizeneptae, mint, asket fern, dry flea, platycodon glaucus nak, matricaria indica of the above medicinal decoction pieces and extract their distilled oil, and let the left water standby. Mix the dregs of decoction with asket fern, dry flea, Platycodon glaucus Nak and add water, then distill and filter them, unite the filtered liquids and have them condensed, add ethanol into the condensed liquid and put them in the cold storage still, after that, filter and condense them again, add supplementary materials and the distilled oil to the condensed liquid. After all this, make the mixture into oral liquid or syrups, granule preparation, small pills, tablet (solvable or scattered tablets), capsuls(soft capsula) and so on. This invented medicine has the effective functions of anti-virus, anti-bacteria, fever relieving, killing pains, antiphlogosis. Clinical applications show It has obvious effectiveness in treating infant cold with the recovering efficiency of above 90%, without side effects.
Description
One, technical field
The invention belongs to the field of Chinese medicines, being specifically related to a kind of is the medicine and preparation method thereof of the treatment infantile common cold made of raw material with Chinese medicine.
Two, background technology
The child is a colony with special physiological characteristics, is in the stage of growth promoter.The function of each system of body and each organ is immaturity, particularly infant still, and the unify growth of hormonal system of liver, renal function, central nervous system is still unsound, and poor to metabolism, drainage and the toleration of many medicines, medication must be careful.There is statistics to show that the medicine of domestic market 90.0% does not all have child's dosage form.Child's sickness rate is higher than the adult, and the ill child of China accounts for more than 20.0% of total ill population, but the special-purpose medicaments that is used for child's common disease seldom, can not satisfy the needs of child health care cause.
This medicine is the Chinese medicine preparation of maximum witness type anemopyretic cold in catching a cold at usual diseases of childhood specially, has taken all factors into consideration children's's physiology, pathological characteristic, the good medicine of the treatment infantile anemopyretic cold of development.Through clinical verification, evident in efficacy, have no side effect, the recovery from illness obvious effective rate is more than 90.0%.Experimentation shows, this preparation has Comprehensive Treatment effects such as resisiting influenza virus, analgesic, pain relieving, antiinflammatory, embodied the characteristic of Chinese herb decoction treatment infantile common cold.
Three, summary of the invention
The objective of the invention is to the cause of disease, a kind of Chinese medicine that can effectively treat infantile anemopyretic cold is provided at infantile anemopyretic cold; Another object of the present invention also provides the preparation method of this medicine.
Solution of the present invention is based on theory of Chinese medical science to pathogenetic understanding of infantile anemopyretic cold and Therapeutic Principle, in conjunction with the clinical experience of diagnosis and treatment primary disease for many years, and repeated screening, the Chinese medicine of development meticulously.
The objective of the invention is to realize that by following technical proposal medicine of the present invention is made by following raw materials by weight proportions:
Flos Lonicerae 6～15g, Fructus Forsythiae 6～10g, Herba Schizonepetae 6～10g, Herba Menthae 3～6g, Rhizoma Osmundae 12～15g, Rhizoma Paridis 10～15g, Radix Platycodonis 3～6g, Flos Chrysanthemi Indici 9～15g.
The sickness rate height of infantile common cold, the differentiation of symptoms and signs for classification of syndrome of infantile common cold are again maximum with the anemopyretic cold.Flos Lonicerae is a monarch drug in the side.The Flos Lonicerae sweet in the mouth, cold in nature, return lung, the heart, stomach warp, function heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome, diffusing swollen, the eliminating pathogenic heat from blood to cure dysentery of eliminating carbuncle.Ministerial drug in the Fructus Forsythiae side of being.The Fructus Forsythiae bitter in the mouth, cold nature is returned lung, the heart, gallbladder meridian, function clearing away and dispersing lung-heat, clearing away heart-fire for tranquillization, removing toxic substances and promoting subsidence of swelling.Herba Menthae, Herba Schizonepetae, Rhizoma Osmundae, Rhizoma Paridis, Radix Platycodonis, Flos Chrysanthemi Indici etc. are adjuvant, are total to the tool dispelling wind to relieve the exterior syndrome, the merit of heat-clearing and toxic substances removing.
The preparation method of medicine of the present invention, its method step is as follows:
(1) each crude drug described in the general side according to concocted specification, is made into the suitable prepared slices of Chinese crude drugs;
(2) Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with the described fundametal component of the prepared slices of Chinese crude drugs adds 6～10 times of water gagings extraction volatile oil, and device is deposited in addition, and also the device storage is standby in addition for water liquid; Medicinal residues and Rhizoma Osmundae, flea body, Radix Platycodonis add 8～12 times of water gaging heating extraction 1～1.5 hour after merging, and filter, and add 6～10 times of water gagings again and extract 1～1.5 hour, filter merging filtrate and above-mentioned water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) in spissated medicinal liquid, add 95% ethanol to containing alcohol amount 70%, cold preservation was left standstill 24～48 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be condensed into thick paste or extractum, add conventional adjuvant required when preparing different dosage form, add the volatile oil of step (2), method of Chinese medicinal with routine is prepared into peroral dosage form commonly used again, as oral liquid or syrup, granule, micropill, tablet (containing effervescent tablet, dispersible tablet etc.), capsule (containing soft capsule) etc.
Medicine of the present invention has dispelling wind to relieve the exterior syndrome, and the effect of heat-clearing and toxic substances removing is used for the infantile common cold wind-heat syndrome: the heating, the headache, the nasal obstruction watery nasal discharge, sneeze, the cough, hypohidrosis, general malaise, swallow red, red tongue, thin white fur of tongue or BOHUANG, floating and rapid pulse, fingerprint purple.
Pharmacological testing studies show that: this medicine has obvious inhibitory action to influenza virus in the Embryo Gallus domesticus, with matched group produce effects is arranged relatively; Rat fever due to the dry yeast there is the better antipyretic effect in the body, can resist glacial acetic acid and cause the reaction of mice painful, has analgesic activity, can obviously suppress glacial acetic acid and cause the increase of mice capillary permeability, significantly antiinflammatory action is arranged, can obviously alleviate dimethylbenzene induced mice auricle swelling degree and swelling rate, show the inflammatory reaction that can resist due to the dimethylbenzene, have antiinflammatory action.Can draw this product by above test and have good antiviral, antibacterial, analgesic, analgesia, antiinflammatory action.
We have good curative effect through clinical practice for the anemopyretic cold of infantile common cold card, and the recovery from illness obvious effective rate is more than 90.0%, clinically do not find any toxic and side effects.
Four, the specific embodiment
Embodiment 1: the medicine of treatment infantile common cold of the present invention, make by following materials of weight proportions medicine:
Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g.
Embodiment 2: the preparation method of peaceful oral liquid of medicine gold of the present invention or syrup, and its step is as follows:
(1) takes by weighing the crude drug (for the prepared slices of Chinese crude drugs after concocting) of certain multiple by the weight of following folk prescription flavour of a drug: Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g;
(2) flavour of a drug Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with several times folk prescription weight adds 10 times of water gagings extraction volatile oil, and device is deposited in addition, and water liquid device is in addition stored standby; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 10 times of water gagings again and extract 1.5 hours, filter merging filtrate and go up step water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) add 95% ethanol to containing alcohol amount 70% in medicinal liquid, cold preservation was left standstill 48 hours, filtered, filtrate recycling ethanol is to there not being the alcohol flavor, add volatile oil and an amount of distilled water transfer to 1: 1 (medical material: medicinal liquid), add sodium benzoate a little, correctives is an amount of, stir evenly, filter embedding, sterilization, oral liquid or syrup are promptly made in packing (10ml/ props up).
Embodiment 3: the granule preparation of medicine of the present invention, and its step is as follows:
(1) takes by weighing the crude drug (for the prepared slices of Chinese crude drugs after concocting) of certain multiple by the weight of following folk prescription flavour of a drug: Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g;
(2) flavour of a drug Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with several times folk prescription weight adds 10 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin, and water liquid device is in addition stored standby; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 10 times of water gagings again and extract 1.5 hours, filter merging filtrate and go up step water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) add 95% ethanol to containing alcohol amount 70% in medicinal liquid, cold preservation was left standstill 48 hours, filtered, and filtrate recycling ethanol continues to be concentrated into thick extractum to there not being the alcohol flavor, drying adds dextrin, and mixing is granulated drying, add volatile oil clathrate compound, mixing, packing is promptly made granule.
Embodiment 4: the pellet preparation of medicine of the present invention, and its step is as follows:
(1) take by weighing the crude drug (for the prepared slices of Chinese crude drugs after concocting) of certain multiple by the weight of following folk prescription flavour of a drug:
Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g;
(2) flavour of a drug Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with several times folk prescription weight adds 10 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin, and water liquid device is in addition stored standby; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 10 times of water gagings again and extract 1.5 hours, filter merging filtrate and above-mentioned water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) add 95% ethanol to containing alcohol amount 70% in medicinal liquid, cold preservation was left standstill 48 hours, filtered, filtrate recycling ethanol continues to be concentrated into thick extractum, drying to there not being the alcohol flavor, pulverize, add volatile oil clathrate compound, mixing adds adjuvants such as an amount of microcrystalline Cellulose, employing is extruded round as a ball or coating is made technology such as ball and prepared micropill, drying, packing is promptly made pellet.
Embodiment 5: the tablet of medicine of the present invention, effervescent tablet, dispersible tablet preparation method, and its step is as follows:
(1) weight of following folk prescription flavour of a drug takes by weighing the crude drug (for the prepared slices of Chinese crude drugs after concocting) of certain multiple: Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g;
(2) flavour of a drug Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with several times folk prescription weight adds 10 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin, and water liquid device is in addition stored standby; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 10 times of water gagings again and extract 1.5 hours, filter merging filtrate and go up step water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) add 95% ethanol to containing alcohol amount 70% in medicinal liquid, cold preservation was left standstill 48 hours, filtered, and filtrate recycling ethanol continues to be concentrated into thick extractum to there not being the alcohol flavor, and drying adds cyclodextrin clathrate, starch etc., and mixing is granulated, and tabletting is made oral tablet; Or add citric acid and sodium bicarbonate tabletting, make effervescent tablet; Or add adjuvants such as carboxymethyl starch sodium and make dispersible tablet.
Embodiment 6: the hard capsule of medicine of the present invention or soft capsule preparation method, and its step is as follows:
(1) weight of following folk prescription flavour of a drug takes by weighing the crude drug (for the prepared slices of Chinese crude drugs after concocting) of certain multiple: Flos Lonicerae 10g, Fructus Forsythiae 10g, Herba Schizonepetae 10g, Herba Menthae 6g, Rhizoma Osmundae 15g, Rhizoma Paridis 12g, Radix Platycodonis 5g, Flos Chrysanthemi Indici 10g;
(2) flavour of a drug Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, the Flos Chrysanthemi Indici with several times folk prescription weight adds 10 times of water gagings extraction volatile oil, and it is standby to be rolled into volatile oil clathrate compound with cyclodextrin, and water liquid device is in addition stored standby; Medicinal residues add 10 times of water gaging heating extraction 1.5 hours with remaining each medicine, filter, and add 10 times of water gagings again and extract 1.5 hours, filter merging filtrate and go up step water the liquid, (medical material: medicinal liquid) that is concentrated into 2: 1;
(3) add 95% ethanol to containing alcohol amount 70% in medicinal liquid, cold preservation was left standstill 48 hours, filtered, and filtrate recycling ethanol continues to be concentrated into thick extractum to there not being the alcohol flavor, and drying adds cyclodextrin clathrate, starch etc., and mixing is granulated, and capsule charge is made hard capsule; Or get above-mentioned powdered extract powder, and adding above-mentioned volatile oil and an amount of vegetable oil or Polyethylene Glycol and make suspension, the filling soft capsule is made soft capsule.
Embodiment 7:
(1) the outer antivirus action of the halfbody of the peaceful oral liquid of gold
(1) direct repression.The medicinal liquid of different extension rates is mixed with the influenza virus liquid of equivalent, and 37 ℃ of effects were inoculated in Embryo Gallus domesticus after 2 hours, and 0.2ml/ only cultivated 48 hours for 37 ℃, took out, and 4 ℃ of refrigerator overnight are collected allantoic fluid, measure hemagglutinative titer, observe and directly suppress virus function; Establish positive control and blank simultaneously.The results are shown in Table 1.
The different dilution factor medicinal liquids of table 1 to the direct repression of influenza virus (x ± s, n=10)
| Group | Extension rate | Hemagglutinative titer | P * |
| Medicinal liquid virazole group normal saline matched group | 16 times 32 times 64 times 128 times 256 times 512 times | 1.9633±0.1269 2.2944±0.1454 2.2944±0.1454 2.4148±0.1454 2.3546±0.1587 2.4148±0.1454 2.2343±0.2558 2.7667±0.1554 | ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 |
*Compare with the normal saline group
(2) therapeutical effect.With the influenza virus inoculated into chick embryo, 0.1ml/ only cultivated 1 hour for 37 ℃, inoculated the medicinal liquid of different extension rates earlier, and 0.1ml/ only cultivated 48 hours for 37 ℃, took out, and 4 ℃ of refrigerator overnight are collected allantoic fluid, measure hemagglutinative titer, observe therapeutical effect; Establish positive control and blank simultaneously.The results are shown in Table 2.
The different dilution factor medicinal liquids of table 2 to influenza virus infect the Embryo Gallus domesticus therapeutical effect (x ± s, n=10)
| Group | Extension rate | Hemagglutinative titer | P * |
| Medicinal liquid virazole group normal saline matched group | 16 times 32 times 64 times 128 times 256 times 512 times | 2.1138±0.2478 2.1740±0.1709 2.2643±0.1269 2.3245±0.1587 2.4449±0.1269 2.6256±0.1555 2.2343±0.2558 2.7667±0.1554 | ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.01 ＜0.05 |
*Compare with the normal saline group
The result shows that the peaceful oral liquid of gold can reduce hirst's hemagglutination tires, and suppresses influenza virus hypertrophy in Embryo Gallus domesticus, and its difference has significance meaning (P＜0.01).Drug quality concentration can suppress the hypertrophy of influenza A virus fully in Embryo Gallus domesticus at 2～0.5g/ml; Concentration is in 2g/ml～0.0625g/ml scope, in Embryo Gallus domesticus influenza A virus had inhibitory action more than 64 times or 64 times, with virazole there was no significant difference relatively, along with the reduction of drug level, the inhibitory action of virus weakened gradually.
(2) the peaceful oral liquid of gold is to the refrigeration function of rat fever due to the dry yeast
Get 120 of male SD rats, body weight 160～180g.Survey normal body temperature, every day 3 times, continuous 3 days.Experiment day is per hour surveyed body temperature 1 time, continuous 3 times, chooses the rat that the body temperature change is not higher than 0.3 ℃ and is used for experiment.Get qualified rat, every Mus is in back subcutaneous injection 20% dry yeast solution 12ml/kg, selects raise 64～80 of＞1 ℃ of persons of rat temperature after 4 hours, is divided into 5 groups at random: 1. blank group: NS 10ml/kg; 2. aspirin group: 0.3g/kg: the 3. peaceful I group of gold: 6.5g/kg; 4. the peaceful II of gold organizes: 13g/kg; 5. the peaceful III of gold organizes: 26g/kg.Each group is all by the volume gastric infusion of 20ml/kg.After administration 30,60,90,120,180,240min observes rat temperature and changes.The results are shown in Table 3.
The result shows, dosage and heavy dose of rat temperature that can obviously reduce rat fever due to the dry yeast relatively have significant difference (p＜0.05,0.01) with the blank group in the peaceful oral liquid of gold, show to have the better antipyretic effect.
The peaceful oral liquid of table 3 gold is to the influence of rat fever body temperature due to the dry yeast (X ± S)
| Group | Dosage (g/kg) | Number of animals (only) | Normal body temperature (℃) | Heating body temperature (℃) | Body temperature reduction value after the administration (℃) (min) | |||||
| 30 | 60 | 90 | 120 | 180 | 240 | |||||
| The peaceful III group of the peaceful II group of the peaceful I group of blank group aspirin group gold gold gold | - 0.3 6.5 13 26 | 10 12 12 12 12 | 38.8±0.40 38.9±0.46 38.9±0.40 38.8±0.45 38.8±0.37 | 39.88 ±0.61 39.90 ±0.51 40.10 ±0.35 39.90 ±0.42 39.80 ±0.50 | 0.08 ±0.41 0.60 * ±0.43 0.10 ±0.35 0.30 ±0.42 0.20 ±0.50 | 0.12 ±0.45 0.90 ** ±0.53 0.30 ±0.30 0.40 ±0.38 0.60 * ±0.23 | 0.28 ±0.61 0.90 ** ±0.43 0.65 ±0.35 0.90 * ±0.30 1.00 * ±0.30 | 0.88 ±0.50 1.00 ** ±0.46 0.65 ±0.51 1.10 ** ±0.40 0.90 ** ±0.30 | 0.88 ±0.40 1.10 ** ±0.43 0.90 * ±0.47 1.00 ** ±0.45 1.30 ** ±0.35 | 1.28 ±0.40 1.10 ** ±0.43 1.10 * ±0.45 1.10 ** ±0.40 1.30 ** ±0.40 |
P＜0.05,
*Compare with the blank group p＜0.01
(3) the peaceful oral liquid of gold causes the influence of mice pain to glacial acetic acid
Get 120 of KM mices, body weight 19～21g, ♀ ♂ half and half.Be divided into 4 groups at random: be respectively 1. blank group: NS 10ml/kg; 2. aspirin group: 0.3g/kg; 3. the peaceful I of gold organizes: 13g/kg; 4. the peaceful II of gold organizes: 26g/kg.Each group is pressed 10ml/kg gastric infusion every day 1 time, gives 3 continuously.Behind the last administration 0.5h, lumbar injection 0.6% glacial acetic acid 0.2ml/ only respectively organizes writhing response number of animals and the writhing response number of times that mice occurs in the 15min behind the observation injection glacial acetic acid.The results are shown in Table 4.
The peaceful oral liquid of table 4 gold is to the influence (writhing method) of glacial acetic acid induced mice pain reaction
| Group | Number of animals (only) | Dosage (g/kg) | The writhing response number (inferior/15min) | Writhing response number of animals (only) |
| The peaceful II group of the peaceful I group of blank group aspirin group gold gold | 20 20 20 20 | 0.3 0.6 1.3 | 19.25±10.24 9.00±6.31 ** 12.3±8.30 * 11.9±8.30 * | 0 2 0 2 |
*P＜0.05,
*P＜0.01 and blank group
The result shows that peaceful two the dosage groups of oral liquid of gold can obviously reduce the writhing response number of times of glacial acetic acid induced mice, with blank group comparing difference remarkable (p＜0.05).Show that the peaceful oral liquid of gold can resist the painful reaction of glacial acetic acid induced mice, has analgesic activity.
(4) the peaceful oral liquid of gold is to the influence of mouse peritoneal capillary permeability
Get 60 of KM mices, male and female half and half, body weight 19～21g.Be divided into 4 groups at random by body weight: be respectively 1. blank group: NS 10ml/kg; 2. Dexamethasone group: 2mg/kg; 3. children's Jin Ning I organizes: 13g/kg; 4. children's Jin Ning II organizes: 26g/kg.Each group is pressed the volume gastric infusion 1 time of 20ml/kg every day by above-mentioned dosage, for three days on end.Behind the last administration 30min, tail vein injection 0.5% azovan blue 0.1ml/10g, lumbar injection 0.6% glacial acetic acid 0.2ml/ is only simultaneously.Take off cervical vertebra behind the 20min and put to death mice,, extract the about 4.5ml of abdominal cavity washing liquid out with 5ml normal saline flushing abdominal cavity.The centrifugal 5min of 2000rpm measures trap in the 590nm place.The results are shown in Table 5.
The peaceful oral liquid of table 5 gold is to the influence of mouse peritoneal capillary permeability (X ± S)
| Group | Number of animals (only) | Dosage (g/kg) | Trap value (A) |
| Blank group Dexamethasone group children's Jin Ning I group children's Jin Ning II group | 10 10 10 10 | - 2mg/kg 13 26 | 0.481±0.067 0.370±0.075 ** 0.400±0.046 * 0.387±0.075 ** |
*P＜0.05,
*P＜0.01 and blank group
The result shows, with the blank group relatively, dosage and heavy dose of group can significantly suppress glacial acetic acid and cause the mice capillary permeability and increase (p＜0.05,0.01) during gold was peaceful.Show that the peaceful oral liquid of gold has significantly antiinflammatory action.
(5) influence of the peaceful oral liquid xylol induced mice ear swelling of gold
Get 60 of male ICR mouses, body weight 26～29g is divided into 4 groups at random by body weight: be respectively 1. blank group: NS 20ml/kg; 2. Dexamethasone group: 2mg/kg; 3. children's Jin Ning I organizes: 13g/kg; 4. children's Jin Ning II organizes: 26g/kg.Each group is pressed the volume gastric infusion 1 time of 20ml/kg every day by above-mentioned dosage, for three days on end.Be applied to ear both sides, a mice left side with dimethylbenzene 0.1ml behind the last administration 30min.After causing scorching 1h, put to death mice, two ears about cutting, (diameter 9mm) takes off round auricle at same position respectively with card punch, and scales/electronic balance weighing calculates auricle weight, and respectively organizes mice auricle swelling degree (left auricle weight-mouse right ear is wide heavy).Mice auricle swelling degree * 100% of the mice auricle swelling degree of inhibitory rate of intumesce=administration group/blank group.The results are shown in Table 6.
The influence of the peaceful oral liquid xylol of table 6 gold induced mice ear swelling (X ± S)
| Group | Number of animals (only) | Dosage (g/kg) | Auricle weight (mg) | Swelling degree (mg) | Inhibitory rate of intumesce (%) | |
| A left side | Right | |||||
| Blank group Dexamethasone group children's Jin Ning I group children's Jin Ning II group | 10 10 10 10 | - 2mg/kg 13 26 | 23.8 16.1 19.6 17.3 | 8.6 8.8 8.4 8.4 | 15.2 7.3 ** 11.2 8.9 * | - 52 26.4 42.8 |
*P＜0.05,
*Compare with the blank group p＜0.01
The result shows that the peaceful oral liquid heavy dose of gold can obviously alleviate mice auricle swelling degree and swelling rate, with blank group comparing difference significantly (p＜0.05,0.01), shows that the peaceful oral liquid of gold can resist the inflammatory reaction due to the dimethylbenzene, has antiinflammatory action.
Claims (2)
1. a medicine for the treatment of infantile common cold is made by following materials of weight proportions medicine: Flos Lonicerae 6～15g, Fructus Forsythiae 6～10g, Herba Schizonepetae 6～10g, Herba Menthae 3～6g, Rhizoma Osmundae 12～15g, Rhizoma Paridis 10～15g, Radix Platycodonis 3～6g, Flos Chrysanthemi Indici 9～15g.
2. method for preparing the described treatment infantile common cold of claim 1 medicine, its preparation process is as follows:
(1) each crude drug described in the general side according to concocted specification, is made into the suitable prepared slices of Chinese crude drugs;
(2) Flos Lonicerae in the prepared slices of Chinese crude drugs, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Flos Chrysanthemi Indici are added 6～10 times of water gagings and extract volatile oil, device is deposited in addition, and also the device storage is standby in addition for water liquid; Medicinal residues and Rhizoma Osmundae, Rhizoma Paridis, Radix Platycodonis add 8～12 times of water gaging heating extraction 1～1.5 hour after merging, and filter, and add 6～10 times of water gagings again and extract 1～1.5 hour, filter, and merging filtrate and above-mentioned water liquid are concentrated into medical material: medicinal liquid is 2: 1;
(3) in spissated medicinal liquid, add 95% ethanol to containing alcohol amount 70%, cold preservation was left standstill 24～48 hours, filter, filtrate recycling ethanol is to there not being the alcohol flavor, be concentrated into thick paste or extractum, add the proper auxiliary materials of preparation different dosage form, add above-mentioned volatile oil, make oral liquid or syrup, granule, micropill, tablet or effervescent tablet or dispersible tablet, hard capsule or soft capsule with conventional preparation method.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480429B (en) * | 2008-01-11 | 2013-03-20 | 中山市中医院 | Chinese medicine preparation for treating external infection |
| CN106668169A (en) * | 2016-12-29 | 2017-05-17 | 唐才才 | Drug for treating wind-heat type common cold and preparation method thereof |
| CN107303312A (en) * | 2016-04-21 | 2017-10-31 | 徐应乐 | A kind of Chinese medicine for treating children's wind-heat cold |
-
2006
- 2006-08-18 CN CN 200610041371 patent/CN1943632A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101480429B (en) * | 2008-01-11 | 2013-03-20 | 中山市中医院 | Chinese medicine preparation for treating external infection |
| CN107303312A (en) * | 2016-04-21 | 2017-10-31 | 徐应乐 | A kind of Chinese medicine for treating children's wind-heat cold |
| CN106668169A (en) * | 2016-12-29 | 2017-05-17 | 唐才才 | Drug for treating wind-heat type common cold and preparation method thereof |
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