CN1097333A - A kind of pure plant health preparation glycolipid disappears and method for making - Google Patents
A kind of pure plant health preparation glycolipid disappears and method for making Download PDFInfo
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- CN1097333A CN1097333A CN 94105989 CN94105989A CN1097333A CN 1097333 A CN1097333 A CN 1097333A CN 94105989 CN94105989 CN 94105989 CN 94105989 A CN94105989 A CN 94105989A CN 1097333 A CN1097333 A CN 1097333A
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Abstract
The present invention relates to a kind of pure plant health preparation glycolipid and disappear, mainly form,, also can be made into capsule, mixture etc. through decocting, filter, concentrate, can be made into oral liquid after the cold preservation by Cacumen Platycladi or Folium Pini, Fructus Lycii, the Radix Astragali, Fructus Mume and auxiliary element.Glycolipid disappears and is mainly used in the treatment diabetes, and hypoglycemic is effective, and blood glucose is had dual regulation, regulates metabolism simultaneously in addition, and microcirculation improvement improves immunity, strengthens the effect of islet cells secretion function.It is a kind of diabetes specific drug evident in efficacy.
Description
The present invention relates to a kind of health preparation and method for making thereof.
Diabetes are internal medicine frequently-occurring diseases, bring great misery because cause of disease complexity, complication are more, the course of disease is long to patient.Therefore the world of medicine is for many years always all at the research work that carries out the diabetes specific drug in many ways.Doctor trained in Western medicine generally adopts insulin for treating diabetes.Also developed some new drugs in recent years, for example " glyburide " Main Ingredients and Appearance is a tolbutamide, mainly is suitable for the light medium-sized patient that insulin cell still has function.The bonded medicament in Chinese and Western " diabetes pill " is made up of western medicine composition and Chinese medicine astragalus, Radix Rehmanniae, Radix Trichosanthis, has the effect of nourishing kidney-YIN supplementing QI for promoting the production of body fluid, is applicable to more than three, becomes thin, fatigue and lack of strength, patient that glucose in urine blood glucose is high.
The purpose of this invention is to provide a kind of pure galenical with unique formula, it is effective to fall ester for treatment diabetes blood sugar lowering, has no side effect, and has dual regulation and health-care effect.
Pure plant health preparation called after glycolipid disclosed in this invention disappears, and its Main Ingredients and Appearance is Cacumen Platycladi, Fructus Lycii, the Radix Astragali, Fructus Mume and auxiliary composition thereof, and wherein the also available Folium Pini of Cacumen Platycladi replaces.
The method for making that glycolipid disclosed in this invention disappears is that each flavor is decocted with water secondary, and collecting decoction filters.Filtrate is concentrated into certain density after cold preservation, filter, add that water is adjusted total amount, stirred evenly, the fill sterilization promptly gets oral liquid.Glycolipid of the present invention disappears and also can be made into capsule and mixture.
Glycolipid of the present invention disappears and has adopted Chinese extraordinary plant Cacumen Platycladi or Folium Pini in the Main Ingredients and Appearance.Its Western medicine or Chinese medicine and western medicine mixture with existing treatment diabetes is compared, had unique effect.Glycolipid of the present invention disappears, hypoglycemic is effective, and is blood sugar lowering after the first blood fat reducing, and hypoglycemic complements each other.Glycolipid disappears and also has dual regulation, and blood sugar lowering when blood glucose is high rises sugar when blood glucose is low, blood glucose is remained on the healthy level.Glycolipid disappears and also has the metabolism improving of adjusting microcirculation simultaneously, improves immunity and strengthens islet cells secretion function, and strong body is anti-ageing, and good health-care effect is arranged.
Major technique of the present invention thes contents are as follows:
One, the prescription that disappears of glycolipid:
Main component:
Cacumen Platycladi or Folium Pini 1582g-1915g
Radix Astragali 93g
Fructus Lycii 111g
Fructus Mume 56g
Auxiliary element: Rhizoma Polygonati 8g, Radix Polygoni Multiflori 8g, Radix Rehmanniae Preparata 3g, Radix Ophiopogonis 15g, Rhizoma Dioscoreae 25g.
Two, preparation method:
Glycolipid of the present invention disappears and can be made into oral liquid, capsule, mixture, several formulations.
1, oral liquid: Cacumen Platycladi or Folium Pini, the Radix Astragali, Fructus Lycii, Fructus Mume four flavors and auxiliary element Rhizoma Polygonati, the Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Radix Ophiopogonis, Rhizoma Dioscoreae are decocted with water 2 times after by the proportioning weighing, two hours for the first time, one hour for the second time, collecting decoction filters, filtrate is concentrated into relative density 1.07(50 ℃), cold preservation filtered after 72 hours, add that water purification adjusts that total amount stirs evenly, embedding, sterilization promptly.
2, capsule: Cacumen Platycladi or Folium Pini, the Radix Astragali, Fructus Lycii, Fructus Mume four flavors and auxiliary element Rhizoma Polygonati, the Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Radix Ophiopogonis, Rhizoma Dioscoreae are decocted with water secondary after by the proportioning weighing, two hours for the first time, collecting decoction filtered in one hour for the second time, filtrate is concentrated into paste, be ground into Powderedly after the oven dry, sieve (40 order) is in incapsulating, sterilization, the glycolipid that 0.5g is housed in each capsule powder that disappears.
3, mixture: as oral liquor, adopt coarse filtration during filtration, filtrate is concentrated into relative density 1.07(50 ℃), cold preservation is coarse filtration after 72 hours, adds water purification and adjusts total amount, bottling, sterilization, every bottle of 250ml.
Three, the glycolipid character that disappears:
Oral liquid is tan liquid, and little have a precipitation, and the powder in feeble QI perfume (or spice), bitter and puckery flavor, the capsule is a chocolate brown powder, feeble QI perfume (or spice), bitter and puckery flavor.Mixture is the little thick liquid of sepia, little precipitation, feeble QI perfume (or spice), bitter and puckery flavor is arranged.
Four, glycolipid disappears to the treatment of diabetes effect:
Glycolipid of the present invention disappears and shows that through zoopery and clinical practice treatment diabetes, hyperlipidemia are had specially good effect.
1, zoopery result: the alloxan induced hyperglycemia mice is irritated the stomach glycolipid oral liquid (240g, 160g, 80g/kg) that disappears, once a day, continuous six days, the hyperglycemia mouse blood sugar is reduced.This experiment gives the glyburide that mice is equivalent to 100 times of people's consumptions with the positive contrast of clinical glyburide commonly used.Experimental result shows that the glycolipid oral liquid blood sugar reducing function that disappears is obvious, is equivalent to the blood sugar lowering effect of glyburide.
The results are shown in Table 1
| Group | Dosage (g/kg) | Number of animals (only) | The blood sugar lowering residual quantity (mg% * ± SD) |
| Glycolipid disappears | 240 160 80 | 11 11 11 | 143.86±119.35 104.03±71.12 83.18±100.06 |
| Glyburide | 0.015 | 11 | 104.48±62.24 |
| The model contrast | 11 | -8.70±115.14 |
2, clinical application effect:
Through how tame hospital clinical use the proof glycolipid disappear have blood fat reducing, the effect of blood sugar lowering healthy and anti-senility, diabetes are had good curative effect.For example Beijing the 6th hospital 114 routine diabeticss are taken disappear treatment, blood glucose soprano of glycolipid is 567mg%, general all about 300mg%, observe through average 45 days treatment, (obey the glycolipid oral liquid secondary that disappears every day, each 20ml), the transference cure more than three or the improvement of polyphagia, polydipsia, polyuria.Wherein cure 50 examples, account for 50.87%, have remarkable result 36 examples to account for 31.58%, 8 examples that disease takes a turn for the better account for 7.02%, and 12 invalid examples account for 10.53%, and total effective rate reaches 89.47%.
Five, the glycolipid The acute toxicity tests that disappears:
Select for use 20 healthy Kunming mouses to test.Experiment mice is taken glycolipid and is disappeared after the oral liquid, and feed, drainage, breathing, extremity activity are all normal.The body weight normal growth is not seen abnormal responses such as diarrhoea, constipation, drowsiness, excitement, and no poisoning manifestations is not seen the phenomena of mortality, observes all healthy survival of experiment mice seven days.Body weight is 18.75 ± 0.75g before the administration, and administration is 22.20 ± 2.23g after seven days.Result of the test shows that glycolipid disappears the oral liquid maximum tolerated dose greater than the 228ml/kg body weight, promptly greater than 285 times of people's consumption per day (40ml/ days 50kg body weight).
Embodiment 1:
1, prescription:
Cacumen Platycladi 1582g, Fructus Lycii 111g, Radix Astragali 93g, Fructus Mume 56g, Rhizoma Polygonati 8g, Radix Polygoni Multiflori 8g, Radix Rehmanniae Preparata 3g, Radix Ophiopogonis 15g, Rhizoma Dioscoreae 25g.
2, preparation:
(1) oral liquid: above-mentioned each flavor is decocted with water secondary, two hours for the first time, one hour for the second time, collecting decoction filters, and filtrate is concentrated into relative density 1.07(50 ℃), 72 hours after-filtration of cold preservation, adding distil water transfers to total amount 950ml, stir evenly in the embedding vial, every bottle of 10ml, the steam high temperature sterilize is promptly.
(2) capsule: by above-mentioned oral liquid method the secondary decoction liquor is merged after-filtration, filtrate is concentrated into paste, is ground into Powderedly after the oven dry, crosses 40 mesh sieves and gets the 60g glycolipid and disappear.In incapsulating, in each capsule of Co60 irradiation sterilization, the 0.5g glycolipid is housed and disappears.
(3) mixture: by above-mentioned oral liquid method the secondary decoction liquor is merged coarse filtration, filtrate is concentrated into relative density 1.07(50 ℃), cold preservation after 72 hours the coarse filtration adding distil water to adjust total amount be 950ml, bottling, steam high temperature sterilize, every bottle of 250ml.
The glycolipid that above-mentioned prescription and method the make oral liquid that disappears, capsule, mixture all can be used for treatment of diabetes, and effect is obvious.
Embodiment 2:
1, prescription:
Cacumen Platycladi 1915g, Fructus Lycii 111g, Radix Astragali 93g, Fructus Mume 56g, Rhizoma Polygonati 8g, Radix Polygoni Multiflori 8g, Radix Rehmanniae Preparata 3g, Radix Ophiopogonis 15g, Rhizoma Dioscoreae 25g.
2, preparation:
(1) oral liquid: method is with embodiment 1, and after cold preservation was filtered, adding distil water transferred to total amount 1120ml, stirs evenly embedding, every bottle of 10ml, and sterilization is promptly.
(2) capsule: method is with embodiment 1, and the powder after the pulverizing is crossed 40 mesh sieves and got the 70g glycolipid and disappear, and incapsulates sterilization, the 0.5g glycolipid is housed in each capsule disappears.
(3) mixture: method is with embodiment 1, and it is 1120ml that cold preservation coarse filtration adding distil water is adjusted total amount, bottling, sterilization.Every bottle of 250ml.
The glycolipid that above-mentioned prescription and method the make oral liquid that disappears, capsule, mixture all can be used for treatment of diabetes, and effect is obvious.
Embodiment 3:
1, prescription:
Cacumen Platycladi 1665g, Fructus Lycii 111g, Radix Astragali 93g, Fructus Mume 56g, Rhizoma Polygonati 8g, Radix Polygoni Multiflori 8g, Radix Rehmanniae Preparata 3g, Radix Ophiopogonis 15g, Rhizoma Dioscoreae 25g.
2, preparation:
(1) oral liquid: method is with embodiment 1, and after cold preservation was filtered, adding distil water transferred to total amount 1000ml, stirs evenly embedding, every bottle of 10ml, and sterilization is promptly.
(2) capsule: method is with embodiment 1, and the powder after the pulverizing is crossed 40 mesh sieves and got the 65g glycolipid and disappear, and incapsulates sterilization, the 0.5g glycolipid is housed in each capsule disappears.
(3) mixture: method is with embodiment 1, and after the cold preservation coarse filtration, it is 1000ml that adding distil water is adjusted total amount, bottling, sterilization.Every bottle of 250ml.
The glycolipid that above-mentioned prescription and method the make oral liquid that disappears, capsule, mixture all can be used for treatment of diabetes, and effect is obvious.
Embodiment 4:
Cacumen Platycladi in the embodiment 1-3 prescription all can substitute by Folium Pini, and proportioning and preparation method are fully identical with routine 1-3, the glycolipid that the makes oral liquid that disappears, and capsule, mixture all can be used for treatment of diabetes, and effect is obvious.
Claims (5)
1, a kind of pure plant health preparation glycolipid disappears, and it is characterized by this health preparation main component and is:
Cacumen Platycladi or Folium Pini 1582g-1915g
Radix Astragali 93g
Fructus Lycii 111g
Fructus Mume 56g
And auxiliary element
2, pure plant health preparation glycolipid according to claim 1 disappears, and it is characterized by auxiliary element: Rhizoma Polygonati 8g, Radix Polygoni Multiflori 8g, Radix Rehmanniae Preparata 3g, Radix Ophiopogonis 15g, Rhizoma Dioscoreae 25g.
3, pure plant health preparation glycolipid according to claim 1 disappears, and it is characterized by the best proportioning of main component to be: Cacumen Platycladi 1665g, Fructus Lycii 111g, Radix Astragali 93g, Fructus Mume 56g.
4, pure plant health preparation glycolipid according to claim 1 disappears, and it is characterized by this health preparation is oral liquid or capsule or mixture.
5, the method for making that disappears of a kind of pure plant health preparation glycolipid, its preparation method is as follows:
(1) oral liquid: Cacumen Platycladi or Folium Pini, the Radix Astragali, Fructus Lycii, Fructus Mume and auxiliary element are decocted with water secondary after by the proportioning weighing, two hours for the first time, one hour for the second time, collecting decoction filters, filtrate is concentrated into relative density 1.07(50 ℃), cold preservation filtered after 72 hours, add that water purification adjusts that total amount stirs evenly, embedding, sterilization promptly.
(2), capsule: by above-mentioned oral liquid method for making decoct filter after, filtrate is condensed into paste, be ground into after the oven dry Powdered, sieve (40 order), in incapsulating, sterilization, promptly.
(3), mixture: by above-mentioned oral liquid method for making, decoct the back coarse filtration, filtrate is concentrated into relative density 1.07(50 ℃), cold preservation is coarse filtration after 72 hours, adds water purification and adjusts total amount, stirs evenly, bottles, sterilizes promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94105989 CN1097333A (en) | 1994-06-09 | 1994-06-09 | A kind of pure plant health preparation glycolipid disappears and method for making |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 94105989 CN1097333A (en) | 1994-06-09 | 1994-06-09 | A kind of pure plant health preparation glycolipid disappears and method for making |
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| CN1097333A true CN1097333A (en) | 1995-01-18 |
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| CN 94105989 Pending CN1097333A (en) | 1994-06-09 | 1994-06-09 | A kind of pure plant health preparation glycolipid disappears and method for making |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019688A1 (en) * | 1996-11-01 | 1998-05-14 | Sam Chun Dang Pharm. Co., Ltd. | Pharmaceutical composition for treatment of diabetes |
| WO1998032455A1 (en) * | 1997-01-27 | 1998-07-30 | Ling Ji | The extract of pine needle and the use thereof |
| CN102423322A (en) * | 2011-12-23 | 2012-04-25 | 赵全成 | Application of total flavonoids from platycladus orientalis leaves in preparing alpha-glucosidase inhibitor medicament |
| CN103263012A (en) * | 2012-12-31 | 2013-08-28 | 孙丽萍 | Edible and pharmaceutical health-care foodstuff and preparation method thereof |
-
1994
- 1994-06-09 CN CN 94105989 patent/CN1097333A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998019688A1 (en) * | 1996-11-01 | 1998-05-14 | Sam Chun Dang Pharm. Co., Ltd. | Pharmaceutical composition for treatment of diabetes |
| WO1998032455A1 (en) * | 1997-01-27 | 1998-07-30 | Ling Ji | The extract of pine needle and the use thereof |
| CN102423322A (en) * | 2011-12-23 | 2012-04-25 | 赵全成 | Application of total flavonoids from platycladus orientalis leaves in preparing alpha-glucosidase inhibitor medicament |
| CN103263012A (en) * | 2012-12-31 | 2013-08-28 | 孙丽萍 | Edible and pharmaceutical health-care foodstuff and preparation method thereof |
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