CN1306830A - Medicine for treating type II diabetes - Google Patents
Medicine for treating type II diabetes Download PDFInfo
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- CN1306830A CN1306830A CN 00100421 CN00100421A CN1306830A CN 1306830 A CN1306830 A CN 1306830A CN 00100421 CN00100421 CN 00100421 CN 00100421 A CN00100421 A CN 00100421A CN 1306830 A CN1306830 A CN 1306830A
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- 229940079593 drug Drugs 0.000 title claims abstract description 22
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 30
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- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 11
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims description 10
- 239000011653 vitamin D2 Substances 0.000 claims description 10
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- 241000208340 Araliaceae Species 0.000 claims description 4
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 4
- 235000008434 ginseng Nutrition 0.000 claims description 4
- 239000008517 radix Trichosanthis Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 abstract description 6
- 239000002994 raw material Substances 0.000 abstract description 4
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- 235000002678 Ipomoea batatas Nutrition 0.000 abstract 1
- 241001448421 Ophiopogon jaburan Species 0.000 abstract 1
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- 244000046146 Pueraria lobata Species 0.000 abstract 1
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- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 241000218989 Trichosanthes Species 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
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- 239000010440 gypsum Substances 0.000 abstract 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
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- Medicines Containing Plant Substances (AREA)
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Abstract
The invention discloses a medicament for treating type II diabetes, which is prepared from fleece-flower root as main raw material, astragalus root, smoked plum, trichosanthes root, sweet potato, Siberian solomonseal rhizome, red ginseng, schisandra fruit, dried rehmannia root, lilyturf root, gecko, fragrant solomonseal rhizome, kudzu vine root, etc. through steps of disintegrating, disintegrating into powder, tablets, capsules, disintegrating into granules, and oral liquid. Among them, powder is preferable. The Chinese goldthread can be added into the components and ground into fine powder together with the medicines, and the gypsum rubrum is added to prepare a decoction paste, and the decoction paste is mixed with the medicine powder, dried and ground into powder to prepare powder, capsules or water pills, which is particularly suitable for patients with type II diabetes accompanied by 'hot symptoms'.
Description
The present invention relates to a kind of medicine for the treatment of type, particularly is the preparation of preparation of raw material with multiple natural drug.
According to The World Health Organization (WHO) statistics, diabetes are diseases of the fourth-largest causing death in developed country, and global diabetics has people more than 200,000,000, in state-owned more than 2,000 ten thousand.Diabetes threaten increasing to human beings'health and life.To treatment of diabetes, medical circle begins to explore the probability of operative treatment, and the method for reality also is to use Drug therapy.Modern medicine is divided into two types of insulin-dependent and non-insulin-depending types with diabetes.The former is called type, must use insulin and treat; The latter is called type, and insulin can not be used in its treatment.
Physician of all times has created the effective medicine of a large amount of treatment diabetes, but does not still have a kind of can at all the healing so far.Most medicines are that too high blood glucose is lowered, and glucose in urine reduces or turns out cloudy, but the improvement of patient's whole body function status is not had obvious effect, disease relapse after the drug withdrawal.Press the viewpoint of Chinese medicine, belong to " curing the symptoms, not the disease ".Some medicines also are easy to generate drug resistance, and a patient just must change types of drugs after certain medicine of use reaches certain hour, just can keep curative effect.Therefore, the medicine of seeking new effective treatment diabetes remains a task of medical circle.Particularly have no side effect, can fundamentally improve patient's whole body function status, clinical treatment is required especially to have the medicine of late result.
The objective of the invention is to, providing a kind of has sure curative effect to type, particularly can improve patient's whole body functional condition, and late result is medicine preferably.It also has cost characteristics lower, easy to use simultaneously.
By the present invention, be the primary raw material medicine with the Radix Polygoni Multiflori, be equipped with multiple other natural drug, be mixed with the convenient dosage form of using with easier method, can solve the task of treatment type more satisfactorily.
Below the component of medicine of the present invention and its weight are constituted, and formulation method is made an explanation.
One. medicine is formed
The used crude drug of medicine pharmacy of the present invention comprises (usage percentage), and Radix Polygoni Multiflori 12-16% SHENGHUANG 12-16% over sixty years of age Fructus Mume 6-9% Radix Trichosanthis 6-9% Fructus Corni 7-11% processs Rhizoma Polygonati 6-9% Radix Ginseng Rubra 2-3% Fructus Schisandrae Chinensis 3-6% Radix Rehmanniae 6-9% 3-6% Radix Ophiopogonis Gecko 7-10% Rhizoma Polygonati Odorati 3-5% Radix Puerariae 3-5%
Above component is the general side who generally is applicable to type, or claims square substantially, main formula.
Two. formulation method
By above component, medicine of the present invention can be made powder, tablet, capsule, granular pattern electuary, oral liquor and other types of formulations by usual way.Wherein be preferably powder, claim " Radix Polygoni Multiflori blood-sugar reducing powder ".It is that each medicine in the component is ground to the powder respectively, crosses the 80-100 mesh sieve, discard medicinal residues (proportion of goods damageds are no more than 5%), drug powder.
Three. on the basis of above main formula, crude drug increases Rhizoma Coptidis and Mirabilitum crystallina two medicines, then is specially adapted to the patient with traditional Chinese medical science " thermal image " such as low grade fever, rapid pulse, Blushings.
Add Rhizoma Coptidis amount be the 10-12% of above-mentioned main formula medicine gross weight; Add Mirabilitum crystallina amount be the 17-20% of above-mentioned main formula medicine total amount.
Rhizoma Coptidis wherein grinds to the powder, and crosses the 80-100 mesh sieve, discards medicinal residues (proportion of goods damageds are no more than 5%), gets drug powder, and is evenly standby with each medicine gained powder mixes of main formula.
With wherein Mirabilitum crystallina intense fire decocting 1-3 time, total decocting time is 2-3 hour.Decoction liquor is filtered, and merging concentrates, and gets paste.All medicated powder are joined in the Mirabilitum crystallina cream, and mix homogeneously grinds after the drying again and is fine powder.This medicated powder can be taken as powder, also can be encapsulated, and can also water general be ball.
Medicine of the present invention is principal agent (monarch drug) with the Radix Polygoni Multiflori, is equipped with other more than ten kinds of medicines, constitutes " monarch, minister are helped, made " and organically combines, has supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst, tonifying speen and tonifying kidney function, the treatment type is had excellent curative, and using method is simple, expense is low.The present invention and my two inventions in addition---the common composition of " a kind of medicine for the treatment of cerebrovascular and sequela thereof ", " anti-ageing tonifying YANG taste cream " " Radix Polygoni Multiflori is made series greatly ", be used for defying age and old frequently-occurring disease, the merit that having brings back to life benefits mankind, that saves one's life and prolong life is wonderful.
Pharmaceutical formulation of the present invention is not on the books in the classic of TCM.Through to the Chinese Searches of Patent Literature,, contain totally 254 of the patents (patent application) of " Radix Polygoni Multiflori " composition in the component at PIC " A61K " apoplexy due to endogenous wind.Wherein with the treatment diabetes be purposes prescription not and the identical or very close medicine of the raw materials used medicine of medicine of the present invention.
The invention will be further described below in conjunction with embodiment.
Embodiment 1 preparation Radix Polygoni Multiflori blood-sugar reducing powder
Take by weighing and process Radix Polygoni Multiflori 300 gram SHENGHUANG 300 gram Fructus Mume over sixty years of ages 150 gram Radix Trichosanthis 150 gram Fructus Corni 200 grams and process Rhizoma Polygonati 150 gram Radix Ginseng Rubras 50 gram Fructus Schisandrae Chinensis 100 gram Radix Rehmanniaes 150 gram 100 gram Geckos Radix Ophiopogonis 180 gram Rhizoma Polygonati Odorati 90 gram Radix Puerariaes 90 grams
More than each medicine grind to the powder respectively, cross the 80-100 mesh sieve, discard medicinal residues (proportion of goods damageds are no more than 5%), drug powder.
Embodiment 2 preparations are specially adapted to the watered pill of the diabetics of sign " thermal image "
Take by weighing and process Radix Polygoni Multiflori 300 gram SHENGHUANG 300 gram Fructus Mume over sixty years of ages 150 gram Radix Trichosanthis 150 gram Fructus Corni 200 grams and process Rhizoma Polygonati 150 gram Radix Ginseng Rubras 50 gram Fructus Schisandrae Chinensis 100 gram Radix Rehmanniaes 150 gram 100 gram Geckos Radix Ophiopogonis 180 gram Rhizoma Polygonati Odorati 90 gram Radix Puerariaes 90 gram Rhizoma Coptidis 220 gram Mirabilitum crystallinas 380 grams
Above-mentioned each medicine except that Mirabilitum crystallina is ground to the powder respectively, cross the 80-100 mesh sieve, discard medicinal residues (proportion of goods damageds are no more than 5%), it is standby to get the drug powder mix homogeneously.
With Mirabilitum crystallina intense fire decocting 2 hours, filter, concentrate, paste.Standby medicated powder is joined in the Mirabilitum crystallina cream, and mix homogeneously grinds after the oven dry again and is fine powder, and water is general to be the little watered pill.Per 50 gram medicated powder are kept within bounds 10 of 500 plus-minuss of the watered pill.Adult patient is taken 3-5 gram, every day 2-3 time at every turn.Three months per courses of treatment.Can withdraw all Chinese and Western antidiabetic drugs during taking this medicine.
Many tame medical institutions used Drug therapy II type of the present invention (non-insulin-depending type) diabetic 360 examples during 1972 to 1998, evident in efficacy.
Selected patient all meets following diagnostic criteria: 1. fasting glucose is higher than 140mg%; 2. the glucose in urine positive; 3. do not use insulin; 4. tangible clinical symptoms is arranged.
Among this 360 routine patient, male's 260 examples, women's 100 examples; Person 250 people more than 50 years old, maximum 78 years old, 110 people of person below 49 years old, minimum 34 years old; The shortest person of the course of disease 5 months, the longest 15 years, average course of disease 6 years.
Therapeutic Method is, the patient takes Radix Polygoni Multiflori blood-sugar reducing powder 5 grams at every turn, and every day 3 times, three months is a course of treatment.Withdraw all Chinese and Western hypoglycemic medicines during taking this medicine, cooperate with keep on a diet, appropriate exercise and science sleep.
Curative effect is judged by following standard:
Produce effects---1. clinical symptom disappearance; 2. fasting glucose was reduced in normal range; 3. glucose in urine is turned out cloudy.
Effectively---1. clinical symptom disappearance: 2. more than the fasting glucose decline 60mg%; 3. glucose in urine is controlled at (+).
Invalid---two of medications are more than the course of treatment, and 1. clinical symptoms does not have significant change; 2. fasting glucose is still in abnormal ranges; 3. glucose in urine is more than (++).
Therapeutic outcome, in 360 routine patients, produce effects 80 examples account for 22.2%; Effective 230 examples account for 63.8%; Invalid 50 examples account for 13.8%; Total effective rate is 86.1%.
Claims (3)
1. medicine for the treatment of type, it is characterized in that, the used crude drug of pharmacy comprises (usage percentage), and Radix Polygoni Multiflori 12-16% SHENGHUANG 12-16% over sixty years of age Fructus Mume 6-9% Radix Trichosanthis 6-9% Fructus Corni 7-11% processs Rhizoma Polygonati 6-9% Radix Ginseng Rubra 2-3% Fructus Schisandrae Chinensis 3-6% Radix Rehmanniae 6-9% 3-6% Radix Ophiopogonis Gecko 7-10% Rhizoma Polygonati Odorati 3-5% Radix Puerariae 3-5%
2. medicine according to claim 1 is characterized in that, the used crude drug of pharmacy also comprises, be equivalent to the described medicine total amount of claim 1 10-12% Rhizoma Coptidis, be equivalent to the Mirabilitum crystallina of the described medicine total amount of claim 1 17-20%.
3. according to claim 1 and 2 described medicines, it is characterized in that each medicine in the component except that Mirabilitum crystallina grinds to the powder respectively, be fine powder with grinding again behind the Mirabilitum crystallina soft extracts combination drying, make powder, capsule, the watered pill.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 00100421 CN1306830A (en) | 2000-02-01 | 2000-02-01 | Medicine for treating type II diabetes |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN 00100421 CN1306830A (en) | 2000-02-01 | 2000-02-01 | Medicine for treating type II diabetes |
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CN1306830A true CN1306830A (en) | 2001-08-08 |
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CN 00100421 Pending CN1306830A (en) | 2000-02-01 | 2000-02-01 | Medicine for treating type II diabetes |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100455317C (en) * | 2006-09-30 | 2009-01-28 | 郭更雄 | Medicament for treating type 2 diabetes |
CN1977884B (en) * | 2005-12-08 | 2010-05-26 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Medicinal composition for treating diabetes and its preparing method |
CN101147584B (en) * | 2007-11-05 | 2010-08-25 | 聂承和 | Health-care food capable of preventing and treating diabetes and preparation method thereof |
CN103705723A (en) * | 2013-12-20 | 2014-04-09 | 北京亚东生物制药有限公司 | Medicine composition for tonifying kidneys and reducing blood sugar as well as preparation method and application thereof |
-
2000
- 2000-02-01 CN CN 00100421 patent/CN1306830A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1977884B (en) * | 2005-12-08 | 2010-05-26 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Medicinal composition for treating diabetes and its preparing method |
CN100455317C (en) * | 2006-09-30 | 2009-01-28 | 郭更雄 | Medicament for treating type 2 diabetes |
CN101147584B (en) * | 2007-11-05 | 2010-08-25 | 聂承和 | Health-care food capable of preventing and treating diabetes and preparation method thereof |
CN103705723A (en) * | 2013-12-20 | 2014-04-09 | 北京亚东生物制药有限公司 | Medicine composition for tonifying kidneys and reducing blood sugar as well as preparation method and application thereof |
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