Background technology
Diabetes (Diabetes mellitus DM) are the chronic disease of a kind of complex disease because causing, mainly due to sugar, fat, protein metabolism disorder in body, clinically increase with glycosuria as characteristics take blood glucose, and then can cause the synthetic disease of multisystem, many organ injuries, merge cardiovascular, kidney as diabetes; Retina and neural pathological changes, the diseases such as diabetic ketoacidosis.Being divided into clinically insulin-dependent and non-insulin-dependent diabetes mellitus (is type Ⅱdiabetes mellitus Non-Insulin Depeudent Dia betes Meuitus, NIDDM), model case is many with performances such as polyuria, polydipsia, polyphagia can occurring, become thin, be tired, and primary disease belongs to " quenching one's thirst " category of Chinese medicine.
Along with increasing of taking in of the quickening of the raising of living standards of the people, rhythm of life and nutrition is even superfluous, the sickness rate of China's diabetes is constantly soaring, and number of patients has become a startling numeral.Diabetes and complication thereof just China people's healthy and life security in serious harm.Modern medicine it is generally acknowledged that diabetes are relevant with many factors such as body insulin deficit, insulin resistant, inherited genetic factors, hormonal readinesses, the main medicines such as oral antidiabetic drug, euglycemic agent of using are treated, most of Western medicine action pathway are single, very easily cause patient's hypoglycemia, islet beta cell function exhaustion and other are as side effect such as edema, liver injury, the possibility that long-term taking needs dosage and has secondary to lose efficacy, Western medicine can not be controlled chronic complicating diseases effectively in addition.Therefore the application limitations of such chemicals is more.
Modern Chinese medicine treatment diabetes are under the guidance of differentiation of symptoms and signs for classification of syndrome thinking, use the methods such as nourishing YIN and clearing away heat, supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, kidney and spleen invigorating, depressed liver-energy dispersing and QI regulating, benefiting QI for activating blood circulation, invigorating kidney, promoting blood circulation, wherein take invigorating the spleen and replenishing QI, heat clearing away YIN nourishing, blood circulation promoting and blood stasis dispelling as rule for the treatment of.Because compound of Chinese medicine can reach giving consideration to both the incidental and fundamental, effectively prevent and treat the complication of diabetes in the treatment primary symptom, and its mechanism of action and approach show as polytropism, multi-level pharmacology, be difficult for producing the situations such as insulin resistant, the advantage of compound of Chinese medicine diabetes and complication day by day manifests.At present know that after deliberation the Chinese medicine that definite curative effect is arranged mainly contains Radix Panacis Quinquefolii, Radix Ginseng, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Rehmanniae, Radix Rehmanniae Preparata, Fructus Lycii, Herba Dendrobii, Radix Et Rhizoma Rhei, Herb Gynostemmae Pentaphylli, Herba Potentillae Discoloris etc.For diabetes and complication, the single medicinal material that can select is a lot, but needs to select the different rule for the treatment of according to clinical syndrome differentiation, so the scope of application is subject to very big limitation.
Summary of the invention
Technical problem to be solved by this invention is: a kind of medicine for the treatment of diabetes is provided, and its side effect is little, and good effect is applied widely, to overcome the deficiencies in the prior art.
the medicine that is achieved in that the treatment diabetes of the present invention, calculate by weight, comprise 50~70 parts of Radix Trichosanthis, 50~70 parts, Poria, 50~70 parts, Radix Rehmanniae Preparata, 50~70 parts, the Radix Rehmanniae, 50~70 parts of Cortex Lycii, 50~70 parts of Fructus Lyciis, 50~70 parts of Radix Ophiopogonis, 50~70 parts, Gypsum Fibrosum, 50~70 parts of Rhizoma Dioscoreaes, 50~70 parts of the Radix Paeoniae Albas, 25~35 parts of the Rhizoma Anemarrhenaes, 50~70 parts of Rhizoma Coptidis, 50~70 parts of Bombyx Batryticatus, 25~35 parts of Fructus Schisandrae Chinensis, 50~70 parts of Radix Pseudostellariaes, 90~110 parts of Radix Notoginseng, 50~70 parts of Radix Salviae Miltiorrhizaes, 50~70 parts of Radix Glehniaes, 50~70 parts of Pachyrhizua angulatus, 25~35 parts of Cortex Cinnamomis, 50~70 parts of Radix Ginseng Rubra, 50~70 parts of Semen Litchis, 50~70 parts of 45~55 parts of Sanguis Draxonis and Semen Trigonellaes, and comprise at least more than one in 50~70 parts of 50~70 parts of the Radixs Astragali, 50~70 parts of Rhizoma Polygonati Odorati, 50~70 parts of Rhizoma Polygonatis or Herba Dendrobiis.
Preferred scheme is, calculate by weight, comprise 60 parts of 60 parts of Radix Trichosanthis, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and Semen Trigonellaes; And comprise at least more than one in 60 parts of 60 parts of the Radixs Astragali, 60 parts of Rhizoma Polygonati Odorati, 60 parts of Rhizoma Polygonatis or Herba Dendrobiis.
The preparation method of the medicine for the treatment of diabetes, getting Radix Trichosanthis, Rhizoma Polygonati Odorati, the Radix Astragali, Poria, Radix Rehmanniae Preparata, the Radix Rehmanniae, Cortex Lycii, Fructus Lycii, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Dioscoreae, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Herba Dendrobii, Rhizoma Coptidis, Bombyx Batryticatus, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Pseudostellariae, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Glehniae, Pachyrhizua angulatus, Cortex Cinnamomi, Radix Ginseng Rubra, Semen Litchi, Sanguis Draxonis and Semen Trigonellae mixes, mixture is pulverized, get comminuting matter 7~9 gram encapsulation, make Chinese medicine powder.
After pulverizing, crosses mixed material 100 mesh sieves.
the preparation method of the medicine for the treatment of diabetes is got Radix Notoginseng and is pulverized standby, get again Radix Trichosanthis, Rhizoma Polygonati Odorati, the Radix Astragali, Poria, Radix Rehmanniae Preparata, the Radix Rehmanniae, Cortex Lycii, Fructus Lycii, Radix Ophiopogonis, Gypsum Fibrosum, Rhizoma Dioscoreae, the Radix Paeoniae Alba, the Rhizoma Anemarrhenae, Herba Dendrobii, Rhizoma Coptidis, Bombyx Batryticatus, Fructus Schisandrae Chinensis, Rhizoma Polygonati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Radix Glehniae, Pachyrhizua angulatus, Cortex Cinnamomi, Radix Ginseng Rubra, Semen Litchi, Sanguis Draxonis and Semen Trigonellae mix, add the water of 10~15 parts to decoct 1 hour in mixture by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, the each decoction 35 minutes, merge decoction liquor and filter, filtrate is concentrated into to thick shape again, then add the Radix Notoginseng powder mixing after cooling, make Chinese medicine preparation.
After adding the Radix Notoginseng powder mixing, pulverize after drying under reduced pressure carrying out under 80 ℃, cross 60 mesh sieves, incapsulate shell, make hard capsule.
In order to verify effect of the present invention, the medicine finished product has been carried out clinical trial, its result is as follows:
From 2006 to 2011, use this kind drug treatment of diabetic 459 examples, women's 255 examples, male's 204 examples, in mean age 43-61 year, the course of disease is the longest 8 years the shortest half a year, and 80% left and right case concentrates on 5 years courses of disease.Upper elimination type 102 examples wherein, in the side compatibilities such as Radix Trichosanthis, Rhizoma Coptidis, Radix Ophiopogonis can promoting the production of body fluid to quench thirst again can resolving heat and reducing pathogenic fire, play clearing heat and moistening lung, promoting the production of body fluid to quench thirst effect, treat and test blood sugar level after three months, more obvious descender's 100 examples are arranged, 1 routine blood sugar level descends slightly, and 1 routine insulin resistant patient is invalid.In type 281 examples that disappear, the heat of Gypsum Fibrosum, Rhizoma Anemarrhenae lung heat clearing stomach in the side; Radix Rehmanniae, Radix Ophiopogonis the lung benefiting stomach the moon, clearing stomach pathogenic fire purging, the effect of YIN supplementing and fluids increasing play in full side, treat that after five months, the blood glucose average level reaches normal level 252 examples, descend but still more higher person's 17 examples, total effective rate 95.7%, 9 examples of remaininging in 12 examples are thirsty and be hard and dry etc., and symptom is alleviated to some extent.Under type 76 examples (deficiency of both YIN and YANG 3 examples that disappear, deficiency of kidney-YIN 73 examples), after treating half a year, test result shows effective 76 examples, average fasting glucose 12.6mmol/L before treatment, post-prandial glycemia 17.1 mmol/L, average fasting glucose 7.6 mmol/L after treatment, post-prandial glycemia 11.0 mmol/L descend respectively 39.7% and 35.7%.In above-mentioned all types of case therapeutic process, complication rate significantly lowers.
Model case
1, history so-and-so: the man, 50 years old age, live the Guiyang Xiaohe District, find from 3 monthly tests in 2007 and suffer from diabetes, fasting glucose is 14.5mmol/L, post-prandial glycemia is 19.1 mmol/L.Began to take medicine of the present invention 5 months from JIUYUE, 2007, again remove examination in hospital in February, 2008, its fasting glucose is 8.5mmol/L as a result, and post-prandial glycemia is 12.1 mmol/L.
2, Song: the female, 54 years old age, live the Guiyang Nanming District, to find from 7 monthly tests in 2005 and suffer from diabetes, fasting glucose is 13.3mmol/L, post-prandial glycemia is 17.5 mmol/L.Began to take medicine of the present invention 5 months from December, 2008, again remove examination in hospital in May, 2009, its fasting glucose is 6.9mmol/L as a result, and post-prandial glycemia is 10.5 mmol/L.
3, the business so-and-so: the man, 60 years old age, live the Guiyang Nanming District, find from 7 monthly tests in 2006 and suffer from diabetes, fasting glucose is 12.1mmol/L, post-prandial glycemia is 16.7mmol/L.Began to take medicine of the present invention 3 months from March, 2007, again removing examination in hospital, its fasting glucose in November, 2007 is 7.3mmol/L, and post-prandial glycemia is 10.5 mmol/L.
4, Jiang: the man, 45 years old age, live the Guiyang Yunyan District, 3 monthly tests in 2009 are found suffers from diabetes, and fasting glucose is 11.5mmol/L, and post-prandial glycemia is 15.8 mmol/L.Began to take medicine of the present invention 3 months from April, 2010, again remove examination in hospital in August, 2010, its fasting glucose is 6.5mmol/L as a result, and post-prandial glycemia is 10.3mmol/L.
5, deep so-and-so: the female, 48 years old age, live the Zunyi City, Guizhou Province, 10 monthly tests in 2008 are found suffers from diabetes, fasting glucose is 13.4mmol/L, post-prandial glycemia is 17.5 mmol/L.Began to take medicine of the present invention 5 months from October, 2009, again remove examination in hospital in June, 2010, its fasting glucose is 8.1mmol/L as a result, and post-prandial glycemia is 12.4 mmol/L.
Can find out according to the therapeutic outcome of model case, the present invention has comparatively significant hypoglycemic activity to the treatment diabetics, and curative effect is fast, and because the Chinese medicinal components collocation of adopting is reasonable, so side effect is little.
Owing to having adopted technique scheme, compared with prior art, the present invention adopts the screening combination that Chinese medicine formula is optimized, and obtains a kind of medicine that can be applicable to most of glycosuria patients, and this curative effect of medication is good, instant effect, and also side effect is little.The present invention is with low cost, easily implements, and result of use is very good.
The specific embodiment
embodiments of the invention 1: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts of the Radixs Astragali, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Herba Dendrobiis, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Rhizoma Polygonatis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 60 parts of mixing of 50 parts of Sanguis Draxonis and Semen Trigonellae, then pulverize with machinery, after pulverizing, crosses mixed material 100 orders, get comminuting matter 7~9 gram encapsulation, make Chinese medicine powder.Took in front 20 minutes at morning every day, supper.
Embodiments of the invention 2: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and 60 parts of mixing of Semen Trigonellae; Then add the water of 10~15 parts to decoct 1 hour in mixture by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, the each decoction 35 minutes, merge decoction liquor and filter, filtrate is concentrated into to thick shape again, then add the Radix Notoginseng powder mixing after cooling, make Chinese medicine preparation.Took in front 20 minutes at morning every day, supper.
Embodiments of the invention 3: the medicine for the treatment of diabetes, get 60 parts of Radix Trichosanthis, 60 parts of Rhizoma Polygonati Odorati, 60 parts, Poria, 60 parts, Radix Rehmanniae Preparata, 60 parts, the Radix Rehmanniae, 60 parts of Cortex Lycii, 60 parts of Fructus Lyciis, 60 parts of Radix Ophiopogonis, 60 parts, Gypsum Fibrosum, 60 parts of Rhizoma Dioscoreaes, 60 parts of the Radix Paeoniae Albas, 30 parts of the Rhizoma Anemarrhenaes, 60 parts of Rhizoma Coptidis, 60 parts of Bombyx Batryticatus, 30 parts of Fructus Schisandrae Chinensis, 60 parts of Radix Pseudostellariaes, 100 parts of Radix Notoginseng, 60 parts of Radix Salviae Miltiorrhizaes, 60 parts of Radix Glehniaes, 60 parts of Pachyrhizua angulatus, 30 parts of Cortex Cinnamomis, 60 parts of Radix Ginseng Rubra, 60 parts of Semen Litchis, 50 parts of Sanguis Draxonis and 60 parts of mixing of Semen Trigonellae; Then add the water of 10~15 parts to decoct 1 hour in mixture by weight for the first time, add respectively again the decocting of 8~12 times of weight to boil twice, decocted 35 minutes at every turn, merge decoction liquor and filter, filtrate is concentrated into to thick shape again, adds the Radix Notoginseng powder mixing after then cooling; Pulverize after drying under reduced pressure carrying out under 80 ℃, cross 60 mesh sieves, incapsulate shell, make hard capsule.Took in front 20 minutes at morning every day, supper.