CN107441406A

CN107441406A - Treat Chinese medicine preparation of type II diabetes and preparation method thereof

Info

Publication number: CN107441406A
Application number: CN201710699614.7A
Authority: CN
Inventors: 李宏伟; 徐石清; 董辉; 王松; 范婷婷
Original assignee: WUHAN JUN AN PHARMACEUTICAL Co Ltd
Current assignee: WUHAN JUN AN PHARMACEUTICAL Co Ltd
Priority date: 2017-08-16
Filing date: 2017-08-16
Publication date: 2017-12-08

Abstract

The invention discloses a kind of Chinese medicine preparation for treating type II diabetes and preparation method thereof, the Chinese medicine preparation of the treatment type II diabetes mainly includes the raw material of following parts by weight：The wind-weed 100 200,The root of straight ladybell 100 200,The tuber of dwarf lilyturf 100 200,Root of Chinese trichosanthes 100 200,Cassia twig 100 200,Pale red 100 200,Matrimony vine 250 350,The membrane of a chicken's gizzard 50 150,Motherwort 250 350,The bighead atractylodes rhizome 150 250,Colla Corii Asini bead 50 150,Ganoderma lucidum 100 200,Glutinous rehmannia 100 200,Chinese yam 100 200,Pseudo-ginseng 10 30,RADIX PUERARIAE 100 150,River connects 20 60,Malt 50 150,Balloonflower root 100 150,The Radix Astragali 120 160,Barrenwort 50 150,Fructus Corni 50 150,Potentilla discolor 120 160,The root bark of Chinese wolf-berry 50 150,Beggar-ticks 50 150,The red sage root 90,Gorgon fruit 100 150,Granatum 60 120,Oyster 50 150,Wolf's milk 60 120,Semen Cuscutae 50 150,The root of herbaceous peony 50 150,Radix pseudostellariae 100 150,Sealwort 100 150 and cape jasmine 50 150.The present invention fully extracts and retains the active ingredient in medicine, and preparation technology is simple to operation, can effectively treat type II diabetes, without any side effects.

Description

Treat Chinese medicine preparation of type II diabetes and preparation method thereof

Technical field

The present invention relates to medical manufacture field, more particularly to a kind of Chinese medicine preparation for treating type II diabetes and its preparation side Method.

Background technology

Type II diabetes original name, more in the sequela of 35~40 years old, accounts for diabetic Adult Onset's patients with type Ⅰ DM More than 90%, a portion patient is based on insulin resistance, such patient's early symptom unobvious, only it is slight it is weak, It is thirsty, big blood vessel and microvascular complication can often occur before clarifying a diagnosis.Another part patient is lacked with insulin secretion Based on falling into, exogenous insulin is clinically required supplementation with.It is characterized in that concentration of glucose rise and glucose in urine, blood extremely in blood circulation There is typical three-many-one-little symptom when too high in sugar, i.e., multiple, diuresis, more foods and weight loss, and with fatigue and weak.Seriously DKA, hypertonicity diabetic coma can occur for person, and easily merge multi-infection.

Its basic pathogenesis of Chinese medical discrimination is due to dryness-heat stagnating in the interior, and battalion's the moon is burnt, channels stasis blocking；Even delay is with the passing of time, the moon damage And sun, so that deficiency of both qi and yin and then qi deficiency to blood stasis, obstruction of collaterals by blood stasis, lose limbs and support, it is multiple because diseases caused by external factors evil poison, local heat toxin are pented up And send out, often actual situation is mutually joined, intricate, therefore is applied and boiled when differentiation of symptoms and signs for classification of syndrome.Wherein, qi deficiency to blood stasis, stagnation of blood stasis, the resistance of train of thought numbness are outstanding For key, clinically often show as falling positive arteriopalmus decrease or even disappear.With the improvement of living standards, the current diabetes in China Patient's increases increasingly, and Most patients depending on western medicine is treated, and western medicine treatment effect is more obvious, but side effect is larger, Patient easily forms long-term dependence to medicine, is unfavorable for the health of patient itself, and thus providing one kind can safely and effectively control It is necessary to treat the Chinese medicine preparation of type II diabetes.

The content of the invention

It is an object of the invention to solve at least the above, and provide the advantages of at least will be described later.

It is a still further object of the present invention to provide a kind of Chinese medicine preparation for treating type II diabetes, can effectively treat II type Diabetes, it is without any side effects.

It is a still further object of the present invention to provide a kind of preparation method for the Chinese medicine preparation for treating type II diabetes, its is abundant Extract and retain the active ingredient in medicine, preparation technology is simple to operation.

In order to realize according to object of the present invention and further advantage, there is provided a kind of Chinese medicine for treating type II diabetes Preparation, mainly include the raw material of following parts by weight：

It is wind-weed 100-200, the root of straight ladybell 100-200, tuber of dwarf lilyturf 100-200, root of Chinese trichosanthes 100-200, cassia twig 100-200, pale red 100-200, matrimony vine 250-350, the membrane of a chicken's gizzard 50-150, motherwort 250-350, bighead atractylodes rhizome 150-250, Colla Corii Asini bead 50-150, ganoderma lucidum 100-200, glutinous rehmannia 100-200, Chinese yam 100-200, pseudo-ginseng 10-30, RADIX PUERARIAE 100-150, river connect 20-60, malt 50-150, Balloonflower root 100-150, Radix Astragali 120-160, barrenwort 50-150, Fructus Corni 50-150, potentilla discolor 120-160, root bark of Chinese wolf-berry 50-150, Beggar-ticks 50-150, the red sage root 90, Gorgon fruit 100-150, granatum 60-120, oyster 50-150, wolf's milk 60-120, Semen Cuscutae 50-150, root of herbaceous peony 50-150, radix pseudostellariae 100-150, sealwort 100-150 and cape jasmine 50-150.

Preferably, the raw material of following parts by weight is mainly included：The wind-weed 150, the root of straight ladybell 150, the tuber of dwarf lilyturf 150, root of Chinese trichosanthes 150, Cassia twig 150, pale red 150, matrimony vine 300, the membrane of a chicken's gizzard 100, motherwort 300, the bighead atractylodes rhizome 200, Colla Corii Asini bead 100, ganoderma lucidum 150, glutinous rehmannia 150th, Chinese yam 150, pseudo-ginseng 20, RADIX PUERARIAE 120, river connect 40, malt 100, balloonflower root 120, the Radix Astragali 140, barrenwort 100, Fructus Corni 100th, potentilla discolor 140, the root bark of Chinese wolf-berry 100, beggar-ticks 100, the red sage root 90, Gorgon fruit 120, granatum 90, oyster 100, wolf's milk 90, Tu Silk 100, the root of herbaceous peony 100, radix pseudostellariae 120, sealwort 120 and cape jasmine 100.

A kind of preparation method of the Chinese medicine preparation of above-mentioned treatment type II diabetes, comprises the following steps：

Step 1, pseudo-ginseng is broken into fine powder, it is standby that Radix Notoginseng powder is made in the screen cloth crossed more than 100 mesh.

Step 2, by the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, root of Chinese trichosanthes, cassia twig, the pale red, the membrane of a chicken's gizzard, motherwort, the bighead atractylodes rhizome, glutinous rehmannia and mountain Medicine decocts 2 times, and it is standby that medical filtration is made into the first filtrate, adds matrimony vine and decocts medical filtration after 0.5-1.5 hours It is standby that the second filtrate is made；Third time adds 6-10 times of water, 1-3 hour of decoction after Colla Corii Asini bead, ganoderma lucidum is added, by decoction It is standby that the 3rd filtrate is made in filtering.

Step 3, the red sage root decocted 2 times, add 6-10 times of water, decoction 2-4h for the first time；Second of 4-8 times of addition Water, 1-2h is decocted, it is standby that red sage root filtrate is made in medical filtration.

Step 4, by RADIX PUERARIAE, river company, malt, balloonflower root, the Radix Astragali, barrenwort, Fructus Corni, potentilla discolor, the root bark of Chinese wolf-berry, Bidens bipinnata Grass, Gorgon fruit, granatum, oyster, wolf's milk, Semen Cuscutae, the root of herbaceous peony, radix pseudostellariae, sealwort and cape jasmine, refluxing extraction 2 times, for the first time 8-12 times of water is added, second of the water for adding 6-10 times, it is standby that the 4th filtrate is made in medical filtration.

Step 5, by the first filtrate, the second filtrate, the 3rd filtrate, red sage root filtrate and the mixing of the 4th filtrate, be concentrated under reduced pressure into Relative density receives cream when being 1.10-1.20, and the first medicinal extract is made.

Step 6, first Radix Notoginseng powder, starch and Aspartame are mixed, add the first medicinal extract, it is then scattered soft to stir into light pressure Material, stops stirring, incorporation time 25-35min, and the Chinese medicine preparation for the treatment of type II diabetes is made in granulation, dry and whole grain.

Preferably, pseudo-ginseng crosses 200 eye mesh screens in step 1.

Preferably, the decoction process of obtained first filtrate is in step 2：6-10 times of water is added for the first time, decocts 1-3 Individual hour；Second of the water for adding 6-10 times, decocts 2-4 hour.

Preferably, the parameter being concentrated under reduced pressure in step 5 is：Vacuum is -0.05--0.06MPa, decoction evaporating temperature For 60-90 DEG C, steam pressure≤0.05MPa.

Preferably, 50-90 DEG C of drying temperature in step 6, drying time 1.5-3.5h, the moisture of the particle is 3- When 5%, stop drying.

The present invention comprises at least following beneficial effect：

In the present invention, the wind-weed is main ingredient, its clearing lung-heat nourshing kidney, clearing heat-fire, fluid dryness；The tuber of dwarf lilyturf assists a ruler in governing a country, its nourishing Yin and promoting production of body fluid, Moistening lung clears away heart-fire；Compatibility the root of straight ladybell, replenishing the vital essence and removing heat, moistening lung for removing phlegm, reinforcing stomach reg fluid；Root of Chinese trichosanthes, clearing heat and promoting fluid, moistening lung for removing phlegm, detumescence row Purulence；Cassia twig, expelling cold and relieving exterior syndrome, warming meridian, promote yang transforming qi；Matrimony vine, filling liver kidney, strengthening the bones and muscles, moistening lung improving eyesight；The membrane of a chicken's gizzard, digestion gathered food, Antidiarrheal；The bighead atractylodes rhizome, tonifying middle-Jiao and Qi, strengthening the spleen and stomach, eliminate dampness and have diuretic effect, antiemetic rush down；Colla Corii Asini bead, nourishing Yin and moistening lung, tonify the blood and arrest bleeding；Ganoderma lucidum, adjust Save blood glucose, promote sleep；Glutinous rehmannia, phencyclidine；Chinese yam, spleen benefiting and stimulating the appetite, boosting qi and nourishing yin；Pseudo-ginseng, hemostasis, eliminating the phlegm, swelling and pain relieving； Above-mentioned Chinese medicine reasonable compatibility, with supplementing qi and nourishing yin, promoting blood circulation and removing obstruction in channels for originally, clearing heat and detoxicating eliminating evil is mark, sample develops simultaneously；RADIX PUERARIAE, solution Malicious relieving restlessness, promote the production of body fluid to quench thirst；River connects, heat-clearing and damp-drying drug, removing toxic substances；Malt, soothing the liver awake stomach, helps digestion except full, regulating middle-JIAO and making the adverse QI downward；Balloonflower root, facilitaing lung It is relieving sore-throat, eliminating the phlegm, apocenosis, hypoglycemic；The Radix Astragali, tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, pus draining and toxin expelling；Barrenwort, filling liver kidney, Strengthening the bones and muscles, supporing yang strengthening the essence, wind-damp dispelling；Fructus Corni, controlling nocturnal emission with astringent drugs of enriching blood, tonify the liver and kidney, regulating the qi flowing in the channels qi-restoratives, improving eyesight；Potentilla discolor, cool blood are stopped Blood, clearing heat and promoting diuresis, removing toxicity for detumescence；The root bark of Chinese wolf-berry, clearing heat and cooling blood, move back osteopyrexia and fever；Beggar-ticks, clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting；It is red Ginseng, promoting blood circulation, clearing heat and relieving fidgetness；Gorgon fruit, invigorating the spleen to arrest diarrhea, the puckery essence of kidney tonifying；Granatum, relieving diarrhea with astringents, hemostasis；Oyster, hold back cloudy latent Sun, hidroschesis, resolving sputum, softening hard masses；Wolf's milk, clearing heat and detoxicating, cooling blood and hemostasis, removing dampness through diuresis and removing jaundice；Semen Cuscutae, tonifying kidney and benefiting sperm, improving eyesight, stop Sweat；The root of herbaceous peony, enrich blood and hold back cloudy, soft liver analgesic；Radix pseudostellariae, help the moon gas, promote the production of body fluid to quench thirst, adjust lung to moisturize；Sealwort, hypoglycemic, drop blood Pressure；Cape jasmine, heat-clearing and fire-reducing, relieving restlessness diuresis, removing pattogenic heat from the blood and toxic material from the body.

Chinese medicine preparation of the present invention has no adverse effects and toxic side effect, the Chinese medicine preparation treatment type II diabetes it is total Effective percentage reaches 97%, contrasts the medicine of existing other treatment type II diabetes, the Chinese medicine preparation treatment type II diabetes Significant effect.

Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by this The research and practice of invention and be understood by the person skilled in the art.

Brief description of the drawings

Fig. 1 is the process chart of the preparation method of the Chinese medicine preparation for the treatment of type II diabetes of the present invention.

Embodiment

The present invention is described in further detail below in conjunction with the accompanying drawings, to make those skilled in the art with reference to specification text Word can be implemented according to this.

It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more The presence or addition of individual other elements or its combination.

The present invention provides a kind of Chinese medicine preparation for treating type II diabetes, mainly includes the raw material of following parts by weight：

In such scheme, the wind-weed is main ingredient, its clearing lung-heat nourshing kidney, clearing heat-fire, fluid dryness；The tuber of dwarf lilyturf assists a ruler in governing a country, its yin-nourishing Promote the production of body fluid, moistening lung clears away heart-fire；Compatibility the root of straight ladybell, replenishing the vital essence and removing heat, moistening lung for removing phlegm, reinforcing stomach reg fluid；Root of Chinese trichosanthes, clearing heat and promoting fluid, moistening lung for removing phlegm, disappear Swollen apocenosis；Cassia twig, expelling cold and relieving exterior syndrome, warming meridian, promote yang transforming qi；Matrimony vine, filling liver kidney, strengthening the bones and muscles, moistening lung improving eyesight；The membrane of a chicken's gizzard, disappear Dyspepsia, antidiarrheal；The bighead atractylodes rhizome, tonifying middle-Jiao and Qi, strengthening the spleen and stomach, eliminate dampness and have diuretic effect, antiemetic rush down；Colla Corii Asini bead, nourishing Yin and moistening lung, tonify the blood and arrest bleeding；Spirit Sesame, regulation blood glucose, promote sleep；Glutinous rehmannia, phencyclidine；Chinese yam, spleen benefiting and stimulating the appetite, boosting qi and nourishing yin；Pseudo-ginseng, hemostasis, eliminating the phlegm, detumescence Analgesic；Above-mentioned Chinese medicine reasonable compatibility, with supplementing qi and nourishing yin, promoting blood circulation and removing obstruction in channels for originally, clearing heat and detoxicating eliminating evil is mark, sample develops simultaneously；Pachyrhizua angulatus Root, removing toxic substances relieving restlessness, promote the production of body fluid to quench thirst；River connects, heat-clearing and damp-drying drug, removing toxic substances；Malt, soothing the liver awake stomach, helps digestion except full, regulating middle-JIAO and making the adverse QI downward；Balloonflower root, It is facilitaing lung relieving sore-throat, eliminating the phlegm, apocenosis, hypoglycemic；The Radix Astragali, tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, pus draining and toxin expelling；Barrenwort, mend Liver kidney, strengthening the bones and muscles, supporing yang strengthening the essence, wind-damp dispelling；Fructus Corni, controlling nocturnal emission with astringent drugs of enriching blood, tonify the liver and kidney, regulating the qi flowing in the channels qi-restoratives, improving eyesight；Potentilla discolor, it is cool Blood hemostasis, clearing heat and promoting diuresis, removing toxicity for detumescence；The root bark of Chinese wolf-berry, clearing heat and cooling blood, move back osteopyrexia and fever；Beggar-ticks, clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting； The red sage root, promoting blood circulation, clearing heat and relieving fidgetness；Gorgon fruit, invigorating the spleen to arrest diarrhea, the puckery essence of kidney tonifying；Granatum, relieving diarrhea with astringents, hemostasis；Oyster, hold back the moon Checking exuberance of yang, hidroschesis, resolving sputum, softening hard masses；Wolf's milk, clearing heat and detoxicating, cooling blood and hemostasis, removing dampness through diuresis and removing jaundice；Semen Cuscutae, tonifying kidney and benefiting sperm, improving eyesight, stop Sweat；The root of herbaceous peony, enrich blood and hold back cloudy, soft liver analgesic；Radix pseudostellariae, help the moon gas, promote the production of body fluid to quench thirst, adjust lung to moisturize；Sealwort, hypoglycemic, drop blood Pressure；Cape jasmine, heat-clearing and fire-reducing, relieving restlessness diuresis, removing pattogenic heat from the blood and toxic material from the body.

In one preferred scheme, mainly include the raw material of following parts by weight：The wind-weed 150, the root of straight ladybell 150, the tuber of dwarf lilyturf 150, smallpox Powder 150, cassia twig 150, pale red 150, matrimony vine 300, the membrane of a chicken's gizzard 100, motherwort 300, the bighead atractylodes rhizome 200, Colla Corii Asini bead 100, ganoderma lucidum 150, Glutinous rehmannia 150, Chinese yam 150, pseudo-ginseng 20, RADIX PUERARIAE 120, river connect 40, malt 100, balloonflower root 120, the Radix Astragali 140, barrenwort 100, mountain The fruit of medicinal cornel 100, potentilla discolor 140, the root bark of Chinese wolf-berry 100, beggar-ticks 100, the red sage root 90, Gorgon fruit 120, granatum 90, oyster 100, wolf's milk 90th, Semen Cuscutae 100, the root of herbaceous peony 100, radix pseudostellariae 120, sealwort 120 and cape jasmine 100.

In such scheme, using the wind-weed as main ingredient, the tuber of dwarf lilyturf assists a ruler in governing a country, other above-mentioned Chinese medicines of compatibility, logical with supplementing qi and nourishing yin, promoting blood circulation Network is this, and clearing heat and detoxicating eliminating evil is mark, and sample develops simultaneously.The Chinese medicine preparation has no adverse effects and toxic side effect, the Chinese medicine system The total effective rate of agent treatment type II diabetes reaches 97%, the medicine of existing other treatment type II diabetes is contrasted, in described The significant effect of medicine preparation for treating type II diabetes.

As shown in figure 1, a kind of preparation method of the Chinese medicine preparation of above-mentioned treatment type II diabetes, comprises the following steps：

In such scheme, granulation described in step 6 can be completed in the following ways：First by Radix Notoginseng powder, starch, Aspartame It is put into trough type mixing machine to stir 15 minutes, mixes, then the first medicinal extract is slowly added into trough type mixing machine in stream shape, Bian Jia, side is stirred Mix；Mixture in above-mentioned mixer, stir into hand and pinch the softwood agglomerating, light pressure then dissipates, stop stirring, incorporation time 30 Minute, the above-mentioned softwood made is added in particle wobbler hopper, mesh number is 16 mesh, and underlying receiver starts particle and waved Machine, granulation.

The drying of step 6 gained particle can be completed in the following ways：The grain made is put into fluidized drying material pot, It is pushed into boiling drier, power turn-on, by container lifting button, hoisting container, setting drying temperature (70 DEG C), opens heating Valve, start main air blower successively；Particle fluidized state is observed, adjusts air channel air intake valve；After drying 2 as a child, when particle water Divide pellet moisture：During 3-5%, stop drying.

Whole grain described in step 6 can be completed by technological requirement in the following ways, install the mesh number of shaking screen, upper strata scalping 10 mesh；40 mesh on lower floor's dusting cover；Pelletizing machine (particle wobbler) is started uniformly to feed；Particle dispenses；Per packed 10g.

In one preferred scheme, pseudo-ginseng crosses 200 eye mesh screens in step 1.

In one preferred scheme, the decoction process that the first filtrate is made in step 2 is：6-10 times of water is added for the first time, Decoct 1-3 hour；Second of the water for adding 6-10 times, decocts 2-4 hour.

In one preferred scheme, the parameter being concentrated under reduced pressure in step 5 is：Vacuum is -0.05--0.06MPa, liquid medicine steaming It is 60-90 DEG C, steam pressure≤0.05MPa to send out temperature.

In one preferred scheme, 50-90 DEG C of drying temperature in step 6, drying time 1.5-3.5h, the moisture of the particle For 3-5% when, stop drying.

Embodiment 1

A kind of Chinese medicine preparation for treating type II diabetes, mainly include the raw material of following parts by weight：

The wind-weed 100, the root of straight ladybell 100, the tuber of dwarf lilyturf 100, root of Chinese trichosanthes 100, cassia twig 100, pale red 100, matrimony vine 250, the membrane of a chicken's gizzard 50, benefit Brittle Falsepimpernel Herb 250, the bighead atractylodes rhizome 150, Colla Corii Asini bead 50, ganoderma lucidum 100, glutinous rehmannia 100, Chinese yam 100, pseudo-ginseng 10, RADIX PUERARIAE 100, river connect 20, malt 50th, balloonflower root 100, the Radix Astragali 120, barrenwort 50, Fructus Corni 50, potentilla discolor 120, the root bark of Chinese wolf-berry 50, beggar-ticks 50, the red sage root 90, Gorgon fruit 100th, granatum 60, oyster 50, wolf's milk 60, Semen Cuscutae 50, the root of herbaceous peony 50, radix pseudostellariae 100, sealwort 100 and cape jasmine 50.

Embodiment 2

The wind-weed 150, the root of straight ladybell 150, the tuber of dwarf lilyturf 150, root of Chinese trichosanthes 150, cassia twig 150, pale red 150, matrimony vine 300, the membrane of a chicken's gizzard 100, Motherwort 300, the bighead atractylodes rhizome 200, Colla Corii Asini bead 100, ganoderma lucidum 150, glutinous rehmannia 150, Chinese yam 150, pseudo-ginseng 20, RADIX PUERARIAE 120, river connect 40, Malt 100, balloonflower root 120, the Radix Astragali 140, barrenwort 100, Fructus Corni 100, potentilla discolor 140, the root bark of Chinese wolf-berry 100, beggar-ticks 100, pellet Ginseng 90, Gorgon fruit 120, granatum 90, oyster 100, wolf's milk 90, Semen Cuscutae 100, the root of herbaceous peony 100, radix pseudostellariae 120, sealwort 120 with And cape jasmine 100.

Embodiment 3

The wind-weed 200, the root of straight ladybell 200, the tuber of dwarf lilyturf 200, root of Chinese trichosanthes 200, cassia twig 200, pale red 200, matrimony vine 350, the membrane of a chicken's gizzard 150, Motherwort 350, the bighead atractylodes rhizome 250, Colla Corii Asini bead 150, ganoderma lucidum 200, glutinous rehmannia 200, Chinese yam 200, pseudo-ginseng 30, RADIX PUERARIAE 150, river connect 60, Malt 150, balloonflower root 150, the Radix Astragali 160, barrenwort 150, Fructus Corni 150, potentilla discolor 160, the root bark of Chinese wolf-berry 150, beggar-ticks 150, pellet Ginseng 90, Gorgon fruit 150, granatum 120, oyster 150, wolf's milk 120, Semen Cuscutae 150, the root of herbaceous peony 150, radix pseudostellariae 150, sealwort 150 And cape jasmine 150.

Embodiment 4

On the basis of the formula of embodiment 3, a kind of preparation method for the Chinese medicine preparation for treating type II diabetes, including it is following Step：

Step 1, pseudo-ginseng is broken into fine powder, it is standby to cross the obtained Radix Notoginseng powder of 200 eye mesh screens.

Step 2, by the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, root of Chinese trichosanthes, cassia twig, the pale red, the membrane of a chicken's gizzard, motherwort, the bighead atractylodes rhizome, glutinous rehmannia and mountain Medicine decocts 2 times, adds 10 times of water for the first time, decocts 3 hours, and it is standby that medical filtration is made into the first filtrate, second plus Enter 10 times of water, decoct 4 hours, add after matrimony vine decocts 1.5 hours that medical filtration is made into the second filtrate is standby；The 10 times of water is added three times, adds 3 hours of decoction after Colla Corii Asini bead, ganoderma lucidum, it is standby that the 3rd filtrate is made in medical filtration.

Step 3, the red sage root decocted 2 times, add 10 times of water for the first time, decoct 4h；Second of the water for adding 8 times, is decocted 2h, it is standby that red sage root filtrate is made in medical filtration.

Step 4, by RADIX PUERARIAE, river company, malt, balloonflower root, the Radix Astragali, barrenwort, Fructus Corni, potentilla discolor, the root bark of Chinese wolf-berry, Bidens bipinnata Grass, Gorgon fruit, granatum, oyster, wolf's milk, Semen Cuscutae, the root of herbaceous peony, radix pseudostellariae, sealwort and cape jasmine, refluxing extraction 2 times, for the first time 12 times of water is added, second of the water for adding 10 times, it is standby that the 4th filtrate is made in medical filtration.

Step 6, first Radix Notoginseng powder, starch and Aspartame are mixed, add the first medicinal extract, it is then scattered soft to stir into light pressure Material, stops stirring, incorporation time 35min, and the Chinese medicine preparation for the treatment of type II diabetes is made in granulation, dry and whole grain.

Wherein, the parameter being concentrated under reduced pressure in step 5 is：Vacuum is -0.05--0.06MPa, decoction evaporating temperature is 60- 90 DEG C, steam pressure≤0.05MPa.

Wherein, 50-90 DEG C of drying temperature in step 6, drying time 1.5-3.5h, when the moisture of the particle is 3-5%, Stop drying.

Embodiment 5

On the basis of the formula of embodiment 1, a kind of preparation method for the Chinese medicine preparation for treating type II diabetes, including it is following Step：

Step 2, by the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, root of Chinese trichosanthes, cassia twig, the pale red, the membrane of a chicken's gizzard, motherwort, the bighead atractylodes rhizome, glutinous rehmannia and mountain Medicine decocts 2 times, adds 6 times of water for the first time, decocts 1 hour, and it is standby that medical filtration is made into the first filtrate, adds for second 6 times of water, 2 hours are decocted, add after matrimony vine decocts 0.5 hour that medical filtration is made into the second filtrate is standby；3rd The secondary water for adding 6 times, 1 hour of decoction after Colla Corii Asini bead, ganoderma lucidum is added, it is standby that the 3rd filtrate is made in medical filtration.

Step 3, the red sage root decocted 2 times, add 6 times of water for the first time, decoct 2h；Second of the water for adding 4 times, is decocted 1h, it is standby that red sage root filtrate is made in medical filtration.

Step 4, by RADIX PUERARIAE, river company, malt, balloonflower root, the Radix Astragali, barrenwort, Fructus Corni, potentilla discolor, the root bark of Chinese wolf-berry, Bidens bipinnata Grass, Gorgon fruit, granatum, oyster, wolf's milk, Semen Cuscutae, the root of herbaceous peony, radix pseudostellariae, sealwort and cape jasmine, refluxing extraction 2 times, for the first time 8 times of water is added, second of the water for adding 6 times, it is standby that the 4th filtrate is made in medical filtration.

Step 6, first Radix Notoginseng powder, starch and Aspartame are mixed, add the first medicinal extract, it is then scattered soft to stir into light pressure Material, stops stirring, incorporation time 25min, and the Chinese medicine preparation for the treatment of type II diabetes is made in granulation, dry and whole grain.

Embodiment 6

On the basis of the formula of embodiment 2, a kind of preparation method for the Chinese medicine preparation for treating type II diabetes, including it is following Step：

Step 1, pseudo-ginseng 20g is broken into fine powder, cross the screen cloth of 200 mesh, it is standby.

Step 2, wind-weed 150g, the root of straight ladybell 150g, tuber of dwarf lilyturf 150g, root of Chinese trichosanthes 150g, cassia twig 150g, pale red 150g, the membrane of a chicken's gizzard 100g, motherwort 300g, bighead atractylodes rhizome 200g, glutinous rehmannia 150g, Chinese yam 150g, 8 times of amount water of first time add weight, decoct 2 hours, Standby by medical filtration, second measures water by 8 times of add weight, decocts 3 hours, add matrimony vine 300g decoct 1 hour it It is standby afterwards by medical filtration；Third time measures water by 8 times of add weight, adds decoction 2 after Colla Corii Asini bead 100g, ganoderma lucidum 150g Hour, it is standby by medical filtration.

Step 3, merge more than the decoction of 3 times concentrated, be -0.05--0.06MPa in vacuum, decoction evaporating temperature For 60-90 DEG C, concentrated under steam pressure≤0.05MPa, when decoction is concentrated into relative density as (60 DEG C) receipts of 1.10-1.20 Cream.

Step 4, granulation, Radix Notoginseng powder, starch, Aspartame are first put into trough type mixing machine and stirred 15 minutes, is mixed.Again will Medicinal extract is slowly added into trough type mixing machine, Bian Jia, side stirring in stream shape；When the above-mentioned hand that stirs into pinches agglomerating, light pressure then scattered softwood, Stopping stirring, incorporation time is 30 minutes, and the above-mentioned softwood made is added in particle wobbler hopper, and mesh number is 16 mesh, under Put receiver and start particle wobbler, pelletize.

Step 5, dry, the grain made put into fluidized drying material pot, be pushed into boiling drier, power turn-on, By container lifting button, liter carries container, setting drying temperature (70 DEG C), opens heating valve, starts main air blower successively；Observation Grain fluidized state, adjusts air channel air intake valve；After drying 2 as a child, when pellet moisture pellet moisture：During 3.0%-5%, stop Dry.

Step 6, whole grain, by technological requirement, install the mesh number of shaking screen, the mesh of upper strata scalping 10；40 mesh on lower floor's dusting cover； Pelletizing machine (particle wobbler) is started uniformly to feed；Particle dispenses；Per packed 10g,

The usage and dosage of Chinese medicinal granule prepared by embodiment 6,3 times a day, 2 bags every time, warm boiled water,

First, clinical test：

This disease is more common in Middle Age and Aged Patients and diabetic duration is longer, the state of an illness is not satisfied with effector.Follow Chinese medical discrimination original Then, its basic pathogenesis is due to dryness-heat stagnating in the interior, and battalion's the moon is burnt, channels stasis blocking；Even delay is with the passing of time, yin deficiency affecting yang, so that gas is cloudy Two empty and then qi deficiency to blood stasis, obstruction of collaterals by blood stasis, lose limbs and support, it is multiple because diseases caused by external factors evil poison, local heat toxin are pented up and sent out.Often actual situation Mutually ginseng, it is intricate, therefore apply and boil when differentiation of symptoms and signs for classification of syndrome.Wherein, qi deficiency to blood stasis, stagnation of blood stasis, the resistance of train of thought numbness is particularly critical, clinically Often show as falling positive arteriopalmus decrease or even disappear, in a word will be with supplementing qi and nourishing yin, promoting blood circulation and removing obstruction in channels is this, and clearing heat and detoxicating eliminating evil is Mark, sample develop simultaneously.

The effect of the medicine contrast treatment of Chinese medicine preparation of the present invention and the treatment type II diabetes of in the market：

Efficacy assessment standard：

It is effective：Clinical symptoms, sign are obviously improved；

Effectively：Clinical symptoms, sign improve；

It is invalid：Sings and symptoms is without significant change.

2nd, packet and administrated method

It is grouped at random using random table, single blind check experiment method, treatment group and each 100 people of control group.

Treatment group：The Chinese medicinal granule prepared using the embodiment of the present invention 2, every bag of 10g, 2 bags every time, 3 times a day, clothes With 30 days cycles.

Control group：The metformin hydrochloride tablet sold using market, orally, one at a time, 1 times a day, take the cycle 30 My god.

Contrast between two groups of curative effects, as shown in table 1：

The comparison of curative effect between 1 two groups of table

Group	Sufferer number	Effectively	It is effective	It is invalid	It is efficient
						Treatment group	100	97	2	1	97%
Control group	100	75	12	3	75%

As shown in table 1, effective percentage has significant difference between two groups, and treatment group's effective percentage is significantly higher than control group, illustrates institute It is evident in efficacy to state Chinese medicine preparation treatment type II diabetes.100 patients for the treatment of group there are no because of the Chinese medicine preparation before and after treatment Caused adverse reaction, illustrate that this product has higher security, the Chinese medicine preparation is safe and effective, and curative effect is stable, is worthy to be popularized.

Specific case：

Liu, 58 years old, blood glucose was repeatedly higher always, and type II diabetes history is up to 6 years, is during which treated always repeatedly, curative effect Little, body is gradually become thin, and thirsty diuresis, eats easy flesh more.The particle that Chinese medicine preparation is made in the embodiment of the present invention 5 is taken, Every bag of 10g, 2 bags every time, 30 days courses for the treatment of, continuously take 60 days, had no adverse reaction during medication, above-mentioned ill symptomses are obvious Alleviate and even disappear.

Certain is shut out, 67 years old, type II diabetes 15 years, Western medicine was used in combination with injection of insulin, and blood glucose is necessarily controlled, but long It is larger that phase takes Chinese medicine side effect, and causes diabetic complication, takes that Chinese medicine preparation is made in the embodiment of the present invention 6 Grain, every bag of 10g, 2 bags every time, 30 days courses for the treatment of, continuously takes 3 courses for the treatment of, during which has no adverse reaction, and ill symptomses disappear.

Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited In specific details and shown here as the legend with description.

Claims

1. a kind of Chinese medicine preparation for treating type II diabetes, wherein, mainly include the raw materials of following parts by weight：

Wind-weed 100-200, the root of straight ladybell 100-200, tuber of dwarf lilyturf 100-200, root of Chinese trichosanthes 100-200, cassia twig 100-200, pale red 100- 200th, matrimony vine 250-350, the membrane of a chicken's gizzard 50-150, motherwort 250-350, bighead atractylodes rhizome 150-250, Colla Corii Asini bead 50-150, ganoderma lucidum 100- 200th, glutinous rehmannia 100-200, Chinese yam 100-200, pseudo-ginseng 10-30, RADIX PUERARIAE 100-150, river connect 20-60, malt 50-150, balloonflower root 100-150, Radix Astragali 120-160, barrenwort 50-150, Fructus Corni 50-150, potentilla discolor 120-160, root bark of Chinese wolf-berry 50-150, Bidens bipinnata Careless 50-150, the red sage root 90, Gorgon fruit 100-150, granatum 60-120, oyster 50-150, wolf's milk 60-120, Semen Cuscutae 50- 150th, root of herbaceous peony 50-150, radix pseudostellariae 100-150, sealwort 100-150 and cape jasmine 50-150.

2. the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 1, wherein, mainly include the originals of following parts by weight Material：The wind-weed 150, the root of straight ladybell 150, the tuber of dwarf lilyturf 150, root of Chinese trichosanthes 150, cassia twig 150, pale red 150, matrimony vine 300, the membrane of a chicken's gizzard 100, motherwort 300th, the bighead atractylodes rhizome 200, Colla Corii Asini bead 100, ganoderma lucidum 150, glutinous rehmannia 150, Chinese yam 150, pseudo-ginseng 20, RADIX PUERARIAE 120, river connect 40, malt 100th, balloonflower root 120, the Radix Astragali 140, barrenwort 100, Fructus Corni 100, potentilla discolor 140, the root bark of Chinese wolf-berry 100, beggar-ticks 100, the red sage root 90, Gorgon fruit 120, granatum 90, oyster 100, wolf's milk 90, Semen Cuscutae 100, the root of herbaceous peony 100, radix pseudostellariae 120, sealwort 120 and cape jasmine 100。

3. a kind of preparation method of the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 1, wherein, including following step Suddenly：

Step 1, pseudo-ginseng is broken into fine powder, it is standby that Radix Notoginseng powder is made in the screen cloth crossed more than 100 mesh；

Step 2, the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, root of Chinese trichosanthes, cassia twig, the pale red, the membrane of a chicken's gizzard, motherwort, the bighead atractylodes rhizome, glutinous rehmannia and Chinese yam decocted Boil 2 times, it is standby that medical filtration is made into the first filtrate, adds after matrimony vine decocts 0.5-1.5 hours and medical filtration is made Second filtrate is standby；Third time adds 6-10 times of water, 1-3 hour of decoction after Colla Corii Asini bead, ganoderma lucidum is added, by medical filtration It is standby that the 3rd filtrate is made；

Step 3, the red sage root decocted 2 times, add 6-10 times of water, decoction 2-4h for the first time；Second of the water for adding 4-8 times, is decocted 1-2h is boiled, it is standby that medical filtration is made into red sage root filtrate；

Step 4, by RADIX PUERARIAE, river company, malt, balloonflower root, the Radix Astragali, barrenwort, Fructus Corni, potentilla discolor, the root bark of Chinese wolf-berry, beggar-ticks, Gorgon euryale Reality, granatum, oyster, wolf's milk, Semen Cuscutae, the root of herbaceous peony, radix pseudostellariae, sealwort and cape jasmine, refluxing extraction 2 times, add for the first time 8-12 times of water, second of the water for adding 6-10 times, it is standby to be made the 4th filtrate by medical filtration；

Step 5, by the first filtrate, the second filtrate, the 3rd filtrate, red sage root filtrate and the mixing of the 4th filtrate, be concentrated under reduced pressure into relative Density receives cream when being 1.10-1.20, and the first medicinal extract is made；

Step 6, first Radix Notoginseng powder, starch and Aspartame are mixed, add the first medicinal extract, stirred into the softwood that light pressure then dissipates, stop Only stir, incorporation time 25-35min, the Chinese medicine preparation for the treatment of type II diabetes is made in granulation, dry and whole grain.

4. the preparation method of the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 3, wherein, three described in step 1 Seven cross 200 eye mesh screens.

5. the preparation method of the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 3, wherein, the is made in step 2 The decoction process of one filtrate is：6-10 times of water is added for the first time, decocts 1-3 hour；Second of the water for adding 6-10 times, is decocted Boil 2-4 hour.

6. the preparation method of the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 3, wherein, depressurized in step 5 dense The parameter of contracting is：Vacuum is -0.05--0.06MPa, decoction evaporating temperature is 60-90 DEG C, steam pressure≤0.05MPa.

7. the preparation method of the Chinese medicine preparation for the treatment of type II diabetes as claimed in claim 3, wherein, temperature is dried in step 6 50-90 DEG C of degree, drying time 1.5-3.5h, when the moisture of the particle is 3-5%, stop drying.