CN117137988A - Traditional Chinese medicine composition and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition and preparation method and application thereof Download PDFInfo
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- CN117137988A CN117137988A CN202311421885.8A CN202311421885A CN117137988A CN 117137988 A CN117137988 A CN 117137988A CN 202311421885 A CN202311421885 A CN 202311421885A CN 117137988 A CN117137988 A CN 117137988A
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition and a preparation method and application thereof, and solves the problems of dependence and side effects of the existing diabetes medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-9 parts of ginseng, 12-14 parts of winged euonymus twig, 11-13 parts of silkworm excrement, 11-13 parts of lychee seed, 11-13 parts of radix trichosanthis, 11-13 parts of Chinese yam, 4-6 parts of coptis chinensis, 4-6 parts of dogwood, 8-9 parts of red sage root, 8-9 parts of radix puerariae and 8-9 parts of schisandra chinensis. Pulverizing Ginseng radix, saviae Miltiorrhizae radix, and rhizoma Dioscoreae into fine powder; decocting the rest rhizoma Dioscoreae, fructus Schisandrae chinensis, ramulus Euonymi, faeces Bombycis, semen litchi, radix Trichosanthis, coptidis rhizoma, corni fructus and radix Puerariae in water twice, filtering, and mixing filtrates; concentrating the filtrate into soft extract, mixing with the fine powder, drying, pulverizing into fine powder, sieving, and mixing; making into pill with water, drying, and making into pill.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and a preparation method and application thereof.
Background
Diabetes mellitus is a metabolic endocrinopathy, and is classified into primary and secondary. The former accounts for the majority, has genetic tendency, the basic pathology is metabolic disorder caused by absolute or relative insulin hyposecretion and increased glucagon activity, including sugar, protein, fat, water, electrolyte and the like, and acid-base balance disorder is seriously and frequently caused; it is characterized by diabetes, impaired glucose tolerance and abnormal insulin release tests. Clinically, the patients are asymptomatic in early stage, and symptoms such as polyphagia, polydipsia, diuresis, polydipsia, hunger, emaciation or obesity, fatigue and weakness are not caused until the symptoms, and long-term patients often have lesions such as cardiovascular and cerebrovascular diseases, kidney diseases, eyes and nerves. In recent years, with the rapid development of economy, people's lifestyle and eating patterns have changed greatly, and the eating habits of high sugar and high fat have led to a rapid increase in the number of diabetics.
At present, diabetics mainly control blood sugar by taking/injecting hypoglycemic agents for a long time, and have certain side effects. Many hypoglycemic drugs can stimulate insulin secretion, and under the conditions of irregular diet and unreasonable medication scheme of patients, patients are caused to be hypoglycemic, and severe patients can suffer from hypoglycemic coma. In addition, sulfonylurea drugs have certain side effects on liver and kidney, which cause other diseases of the body. And western medicines have strong dependence, are easy to relapse after stopping taking, and are easy to generate drug resistance after long-term taking. Therefore, there is a need to develop a medicament for treating diabetes which addresses both the symptoms and root causes without damaging other body organs.
Diabetes belongs to the field of diabetes in the traditional Chinese medicine field, and ancient and modern doctors mostly consider that consumptive disease damages yin fluid of liver, spleen and kidney to form the disease, and Zhangjing Yue considers middle-jiao disease to be middle-jiao disease, and the disease is in spleen and stomach. Clinically, there are excessive heat and impairment of yin, and yin deficiency and dryness-heat are causal, while the primary diseases are different in the upper, middle and lower aspects, and the primary diseases are different in the initial aspects, and the secondary diseases are mainly three-in-one diseases, namely late yin impairment and yang, manifesting as yin-yang impairment. In conclusion, in combination with the characteristics of Chinese medicine, development of the traditional Chinese medicine as a main means for improving the symptoms of diabetes is imperative.
Disclosure of Invention
In order to solve the problems of the existing diabetes medicines, the invention provides a traditional Chinese medicine composition, and a preparation method and application thereof.
The technical scheme of the invention is as follows:
a traditional Chinese medicine composition is prepared from the following raw materials in parts by weight:
8-9 parts of ginseng, 12-14 parts of winged euonymus twig, 11-13 parts of silkworm excrement, 11-13 parts of lychee seed, 11-13 parts of radix trichosanthis, 11-13 parts of Chinese yam, 4-6 parts of coptis chinensis, 4-6 parts of dogwood, 8-9 parts of red sage root, 8-9 parts of radix puerariae and 8-9 parts of schisandra chinensis.
Preferably, the feed additive is prepared from the following raw materials in parts by weight:
8.5 parts of ginseng, 13.5 parts of winged euonymus twig, 12 parts of silkworm excrement, 12 parts of lychee seed, 12 parts of radix trichosanthis, 12 parts of Chinese yam, 5 parts of coptis chinensis, 5 parts of dogwood, 8.5 parts of red sage root, 8.5 parts of radix puerariae and 8.5 parts of shizandra berry.
Preferably, the Chinese medicinal composition is prepared into pills after being extracted.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
s1, weighing ginseng, red sage root and half of Chinese yam, and crushing into fine powder;
s2, decocting the rest half of Chinese yam, shizandra berry, winged euonymus twig, silkworm excrement, lychee seed, radix trichosanthis, coptis chinensis, dogwood and radix puerariae in water twice, filtering and then combining the filtrates;
s3, concentrating the filtrate into thick paste, mixing with the fine powder in the step S1, drying, pulverizing into fine powder, sieving, and uniformly mixing;
s4, making the fine powder obtained in the step S3 into pills, drying, and preparing the pill-shaped traditional Chinese medicine composition.
Preferably, the decocting conditions in step S2 are:
the first water quantity is 6-8 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1-2 hours;
the second water quantity is 5-7 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1-2 hours.
Preferably, the decocting conditions in step S2 are:
the first water amount is 7 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1.5 hours;
the water quantity for the second time is 6 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1.5 hours.
Preferably, the temperature of the drying treatment in step S4 is not higher than 70 ℃.
Preferably, the weight of the pellet-shaped traditional Chinese medicine composition obtained in the step S4 is 25% -35% of the total weight of the raw materials.
Preferably, the weight of the pellet-shaped Chinese medicinal composition obtained in the step S4 is 29% of the total weight of the raw materials.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating diabetes.
The raw materials in the invention are recorded in pharmacopoeia. Wherein the radix Salviae Miltiorrhizae is dried rhizome of Salvia miltiorrhzab ge of Labiatae, and contains crystalline phenanthrenequinone compound: tanshinone I, tanshinone IIA, tanshinone IIB, cryptotanshinone, hydroxy tanshinone, methyl tanshinone, dihydroxytanshinone I, etc. and isomers thereof. Pharmacological action: the radix salviae miltiorrhizae has the effects of removing blood stasis, relieving pain, activating blood, dredging channels, clearing heart fire and relieving restlessness. The modern researches mainly show that tanshinone has the effects of resisting arteriosclerosis, reducing myocardial infarction area, resisting coagulation and thrombosis, improving microcirculation, protecting liver, regulating tissue repair and regeneration, resisting inflammation and resisting tumor, etc.
The coptis root source is dried rhizome of Coptis chinensis Franch, coptis deltoidea C.Y. Cheng et Hsiao or Coptiseteteta wall of Ranunculaceae, contains berberine, coptisine, methylcoptisine, palmatine, jakogazine, phellodendrine, etc., contains ferulic acid, 3, 4-dihydroxyphenethyl alcohol glucoside, 3-carboxyl-4-hydroxyphenoxyglucoside, 2,3, 4-trihydroxybenzoic acid, etc., and the berberine hydrochloride is hydrophilic quaternary ammonium salt. Pharmacological action: has effects in resisting pathogenic microorganism, relieving inflammation, inhibiting central nervous system, improving cardiovascular function, relieving cerebral ischemia, and reducing blood lipid. Has the functions of treating nongonococcal urethritis, bacillary dysentery, diabetes, etc. clinically.
The ginseng base source is dried root and rhizome of Panax ginseng C.A. Mey of Araliaceae, and the whole plant of Panax ginseng contains chemical components such as saponin and volatile oil. Pharmacological action: has effects in promoting learning and memory, cardiovascular system and blood system, pituitary-adrenocortical system, nucleic acid and protein synthesis, blood sugar, tumor, cell activity, immunity, oxidation and aging.
The Schisandra chinensis source is dry mature fruit of Schisandra chinensis (Turcz.) of Magnoliaceae, and the total lignin content in Schisandra chinensis fruit is 18.1-19.2%. Pharmacological action: has effects in preventing liver injury, protecting against oxygen free radical injury, improving liver detoxification function, resisting aging, tranquilizing mind, improving immunity, relieving ulcer, relieving inflammation, resisting stress, preventing caries, and protecting genital system.
The powder Ge Jiyuan is dry root of Pueraria thomsonii Pueraria thomsoni benth of Leguminosae, contains multiple flavonoid components, mainly daidzein and puerarin. In addition, there are daidzein 4, 7-diglucoside, 7-xyloside puerarin and 4, 6-diacetyl puerarin. Pharmacological action: regulate cardiac function.
The Euonymus alatus (Thunb.) Sieb of Celastraceae contains cardiac glycoside and alkaloid, and also contains 4-stigmastane-3-one, 4-stigmastane-3, 6-dione, etc. Pharmacological action: has effects in reducing blood sugar, increasing myocardial nutritional blood flow, improving oxygen and nutrient supply, inhibiting thrombosis, and relieving arrhythmia.
The silkworm excrement source is dry excrement of silkworm of Bombyx mori Linnaeus of Bombycis, and contains chlorophyll, carotene, beta-sitosterol, cholesterol, ergosterol, tetracosanol, lupulin, and other components, and also contains various free amino acids. Pharmacological action: has inhibiting effect on in vitro liver cancer tissue culture cells.
The radix Trichosanthis is derived from dried root of Trichosanthes kirilowii Maxin or Trichosanthes kirilowii Harlls of Cucurbitaceae, and contains trichosanthin, trichosanthis radix polysaccharide A, B, C, D, E, polysaccharide, bryophyte alkyd, cucurbitacin B, D, etc. Pharmacological action: has abortion inducing, early pregnancy resisting, anticancer, antibacterial, and blood sugar increasing effects.
The cornel source is dried mature pulp of cornel Cornas officinalis Sieb et Zucc of cornelian family, contains tannins and glycosides, and also contains volatile oil and various amino acids. Pharmacological action: has antiinflammatory, antishock, heart strengthening, blood sugar lowering, and immunity enhancing effects.
The litchi seed source is dried mature seed of Lichi chinensis Sonn of Sapindaceae, contains saponin 1.12%, tannin 3.43%, and trace volatile oil contains 3-hydroxy butanone, and bergamotene. Pharmacological action: has the functions of reducing blood sugar and enhancing the oxidization resistance and blood lipid regulation of diabetic rats, and the litchi seeds have toxicity but very low toxicity.
The yam-based source is dried rhizome of Dioscorea opposita Dioscorea opposita thunder. Of Dioscoreaceae, contains diosgenin, dopamine, rhizoma Dioscoreae, allantoin, glycoprotein and polysaccharide. Pharmacological action: has antioxidant and blood sugar reducing effects, and also has certain effects on digestive system and immunity.
Compared with the prior art, the invention has the following specific beneficial effects:
1. from the theory of traditional Chinese medicine, the ginseng taste in the recipe is sweet and warm and supplements deficiency, can tonify qi of lung, spleen and kidney, and can promote the production of body fluid to quench thirst; ramulus Euonymi is bitter in taste and good at strengthening yin, has the effect of cold entering blood, is good at resolving dryness-heat of yin, quenching thirst and clearing fire, and activating blood and dissolving stasis, and the two medicines are combined together to be used as monarch medicines;
qi is the general and blood is the mother of Qi, qi deficiency promotes weakness, blood circulation is unsmooth and is slowly astringed, so that blood stasis is caused, namely 'Qi deficiency is remained'; yin deficiency with excessive fire, decoction of body fluids, homology of body fluids and blood, and lack of body fluids can cause viscous and unsmooth blood, which is called "yin deficiency with blood stagnation"; silkworm excrement and lychee seeds are compatible, and the effects of activating blood and promoting qi circulation are achieved, so that the effect of restoring qi and blood is achieved; radix Trichosanthis is sweet, slightly bitter and slightly cold, and is good at clearing lung and stomach excessive heat, promoting fluid production and quenching thirst; the yam not only can invigorate qi of spleen, lung and kidney, but also can invigorate yin of spleen, lung and kidney; the four materials are taken as ministerial drugs;
coptis chinensis has the effects of clearing stomach fire, and relieving symptoms of hunger, polydipsia and polydipsia; fructus Corni has effects of nourishing liver and kidney, replenishing essence and nourishing yin; the red sage root has the functions of promoting blood circulation to remove blood stasis and promoting tissue regeneration; powder Ge Ganliang, while clearing heat, can promote the ascending of qi of the spleen and stomach to promote the production of body fluid and quench thirst; the four materials are taken as adjuvant drugs;
fructus Schisandrae chinensis is sweet in nature, has effects of invigorating qi, promoting production of body fluid, astringing lung qi, and nourishing kidney yin, and is used as a guiding drug;
the above medicines are combined to make qi and yin both be supplemented and blood stasis be smooth, so that various symptoms of diabetes can be relieved.
2. The prescription of the invention has reasonable design and strict compatibility, and has definite curative effect through long-term clinical verification.
3. The invention is composed of Chinese medicinal materials, has low cost, no toxic or side effect, and can not cause damage to other organs of the body after long-term administration.
Detailed Description
The following examples are provided to better understand the technical aspects of the present invention and should not be construed as limiting the present invention.
Examples
S1, weighing 278g of ginseng, 278g of red sage root and 195g of yam, and crushing into fine powder;
s2, weighing 195g of Chinese yam, 278g of shizandra berry, 444g of winged euonymus twig, 390g of silkworm excrement, 390g of lychee seed, 390g of radix trichosanthis, 167g of rhizoma coptidis, 167g of dogwood and 278g of radix puerariae, adding 7 times of water, decocting for 1.5 hours, filtering, adding 6 times of water, decocting again for 1.5 hours, filtering, and combining the filtrates;
s3, concentrating the filtrate under reduced pressure to obtain thick paste, uniformly mixing the thick paste with the fine powder in the step S1, drying, crushing into fine powder, sieving and uniformly mixing;
s4, making the fine powder obtained in the step S3 into pills, and then drying at 70 ℃ to finally obtain 1000g of the pill-shaped traditional Chinese medicine composition.
Effect example.
50 diabetics are selected, and the ages are 30-60, wherein 25 diabetics are men and 25 women. The 50 diabetics were dosed with the clinical test samples prepared in the above examples three times a day, one granule at a time, eight weeks as a course of treatment.
The treatment effect judgment criteria are as follows:
the effect is shown: the symptoms basically disappear after treatment, the fasting blood sugar is less than 7.2mmol/L, the postprandial blood sugar is less than 8.3mmol/L, the total amount of 24h urine sugar is less than 10.0g, or the total amount of blood sugar and 24h urine sugar is reduced by more than 30 percent compared with the total amount before treatment.
The method is effective: the symptoms are obviously improved after treatment, the fasting blood sugar is less than 8.3mmol/L, the postprandial blood sugar is less than 10.0mmol/L, the total amount of 24h urine sugar is less than 25.0g, or the total amount of blood sugar and 24h urine sugar is reduced by more than 10 percent compared with the total amount before treatment.
Invalidation: the symptoms are not obviously improved after the treatment, and the blood sugar and urine sugar drop does not reach the above standard.
Treatment results: after one treatment course of administration treatment, the blood sugar is detected, 41 patients are effective, 7 patients are effective, 2 patients are ineffective, and the total effective rate is 96 percent.
In conclusion, the medicine provided by the invention accords with the dialectical theory of traditional Chinese medicine in terms of medicinal material selection and compatibility, and has a good effect of treating diabetes.
Typical cases:
1. mr. Prune, 48 years old, had diabetes for nearly one year. By detecting fasting blood glucose 8.6mmol/L, postprandial 2h blood glucose 11.9mmol/L, urine protein++, symptom: dry mouth and tongue, irritability, emaciation, yellow urine and yellow tongue coating. The diagnosis is yin deficiency and internal heat, kidney essence deficiency and diabetes.
After taking the medicine of the embodiment for one treatment period, the dry mouth of the Mr. prune is improved, and the urine color is basically recovered to be normal. The fasting blood glucose of the Mr. prune is detected to be reduced to 6.7mmol/L, the postprandial blood glucose of 2h is 7.5mmol/L, the medicine is stopped after two treatment courses of continuous administration, the fasting blood glucose of the Mr. prune is detected to be 5.5mmol/L, and all other indexes are normal. And returning after one year, wherein all test indexes are normal.
2. The patient is white for women, 36 years old, and symptoms such as thirst, polydipsia, emaciation, dysphoria, poor sleep, slow response and the like appear in the last half year. The fasting blood glucose is detected to be 9.4mmol/L, and the postprandial blood glucose is detected to be 12.8mmol/L for 2h. The primary diagnosis is diabetes.
After taking the medicine described in this example for one treatment period, the symptoms of polydipsia in white women disappeared, the sleep was improved, the emotion was improved, the weight was increased, the fasting blood glucose level was reduced to 7.0mmol/L, and the postprandial blood glucose level was 8.2mmol/L for 2h. And (3) continuing taking for two courses of treatment, and detecting that the fasting blood glucose value is stabilized between 5.8 mmol/L and 6.5mmol/L during the taking period of the white ladies, wherein all other indexes are normal. And returning after stopping taking medicine for one year, and ensuring that all test indexes are normal.
3. The patient is born by the first person, 59 years old, and is diabetic due to polydipsia, polyphagia, diuresis, dizziness, debilitation and the like, and the fasting blood sugar is 13.8mmol/L through detection, which is diagnosed by deficiency of liver-yin and kidney-yin and impairment of both qi and yin.
After taking the medicine of the embodiment for one treatment period, the symptoms are relieved by detecting the fasting blood glucose by 9.4mmol/L, and after continuing to take the medicine for two treatment periods, the medicine for detecting the fasting blood glucose by 7.0mmol/L is effective in treatment, and is consolidated after continuing to take the medicine for two treatment periods. And returning after stopping taking medicine for one year, and ensuring that all test indexes are normal.
It should be noted that the foregoing is only preferred embodiments of the present invention, and these embodiments are based on different implementations of the overall concept of the present invention, and the scope of the present invention is not limited thereto, and any changes or substitutions easily conceivable by those skilled in the art within the technical scope of the present invention should be covered in the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.
Claims (10)
1. The traditional Chinese medicine composition is characterized by being prepared from the following raw materials in parts by weight:
8-9 parts of ginseng, 12-14 parts of winged euonymus twig, 11-13 parts of silkworm excrement, 11-13 parts of lychee seed, 11-13 parts of radix trichosanthis, 11-13 parts of Chinese yam, 4-6 parts of coptis chinensis, 4-6 parts of dogwood, 8-9 parts of red sage root, 8-9 parts of radix puerariae and 8-9 parts of schisandra chinensis.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:
8.5 parts of ginseng, 13.5 parts of winged euonymus twig, 12 parts of silkworm excrement, 12 parts of lychee seed, 12 parts of radix trichosanthis, 12 parts of Chinese yam, 5 parts of coptis chinensis, 5 parts of dogwood, 8.5 parts of red sage root, 8.5 parts of radix puerariae and 8.5 parts of shizandra berry.
3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared into pills after being extracted.
4. A method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 3, comprising the steps of:
s1, weighing ginseng, red sage root and half of Chinese yam, and crushing into fine powder;
s2, decocting the rest half of Chinese yam, shizandra berry, winged euonymus twig, silkworm excrement, lychee seed, radix trichosanthis, coptis chinensis, dogwood and radix puerariae in water twice, filtering and then combining the filtrates;
s3, concentrating the filtrate into thick paste, mixing with the fine powder in the step S1, drying, pulverizing into fine powder, sieving, and uniformly mixing;
s4, making the fine powder obtained in the step S3 into pills, drying, and preparing the pill-shaped traditional Chinese medicine composition.
5. The method of preparing a Chinese medicinal composition according to claim 4, wherein the decocting conditions in step S2 are:
the first water quantity is 6-8 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1-2 hours;
the second water quantity is 5-7 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1-2 hours.
6. The method of preparing a Chinese medicinal composition according to claim 4, wherein the decocting conditions in step S2 are:
the first water amount is 7 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1.5 hours;
the water quantity for the second time is 6 times of the weight of the medicinal materials, and the medicinal materials are decocted for 1.5 hours.
7. The method of preparing a pharmaceutical composition according to claim 4, wherein the drying process in step S4 is performed at a temperature of not higher than 70 ℃.
8. The method for preparing a pharmaceutical composition according to claim 4, wherein the weight of the pellet-shaped pharmaceutical composition obtained in step S4 is 25% -35% of the total weight of the raw materials.
9. The method of preparing a pharmaceutical composition according to claim 4, wherein the weight of the pellet-shaped pharmaceutical composition obtained in step S4 is 29% of the total weight of the raw materials.
10. Use of a Chinese medicinal composition according to any one of claims 1-3 in the manufacture of a medicament for the treatment of diabetes.
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