CN1435209A - Medicine for treating biabetes and preparing process thereof - Google Patents
Medicine for treating biabetes and preparing process thereof Download PDFInfo
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- CN1435209A CN1435209A CN 02113947 CN02113947A CN1435209A CN 1435209 A CN1435209 A CN 1435209A CN 02113947 CN02113947 CN 02113947 CN 02113947 A CN02113947 A CN 02113947A CN 1435209 A CN1435209 A CN 1435209A
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Abstract
A Chinese medicine in the form of medical liquor or others for treating diabetes and hypertension is prepared from 13 Chinese-medicinal materials including ginseng, astragalus root, wolfberry fruit, honeysuckle flower, etc through soaking in liquor, adding trace elements (Cr, Se, Zn, Mg and V), purifying and sterilizing. It has high curative effect.
Description
The present invention relates to a kind of medicine for the treatment of diabetes, specifically, the Chinese herbal and crude drugs preparations that relates to a kind of treatment diabetes made from wine or water and Chinese herbal medicine and trace element or with auxiliary materials such as Chinese herbal medicine and trace element, said preparation can be medicated wine or the decoction made from raw materials such as the Chinese herbal medicine solution of wine or water extraction and trace element, also can be the medicine that powder, powder, electuary, tablet, pill, glue that auxiliary materials such as Chinese herbal medicine and trace element are made such as assist at various dosage forms.The invention still further relates to the preparation method of this medicine.
Diabetes are diseases of a kind of serious harm human health, also are common frdquently encountered diseases, and whole world diabetics reaches people more than 100,000,000 at present, and also there are more than 2,000 ten thousand people in China, and increases year by year, and case fatality rate is only second to cancer and heart disease.This disease does not heal all the life, produces multiple complications simultaneously.Because the absolute or relative shortage of insulin in the blood samples of patients, cause carbohydrate metabolism disturbance in the body, cause blood glucose, glucose in urine, blood fat to raise, it is many food to occur, drinking water copiously, frequent micturition, body weight or " three-many-one-little " symptom such as few, whole body microangiopathies appears in the middle and advanced stage patient, and cardiovascular mortality reaches 80%, and diabetes kidney function failure and cerebrovascular accident also are the common causes of death of diabetics.Therefore, diabetes are current a great problems of the world of medicine both at home and abroad, and for a long time, people have have constantly researched and developed out the medicine of tens kinds of treatment diabetes, comprising Western medicine and Chinese patent medicine, though these medicines also have curative effect preferably, also have following shortcoming:
1, Western medicine generally all has in various degree infringement or untoward reaction to liver, kidney, cardiovascular and cerebrovascular vessel etc., must the strict control dosage and the course of treatment., side effect low as (1) biguanide drug curative effect used greatly, for a long time and produced hyperlactacidemia; (2) iodine ureas medicine intersection is easily irritated, and the later stage produces secondary failure; (3) sulphonyl class medicine causes that easily sudden hypoglycemia causes stupor and dead, and mortality rate is up to 11%; (4) insulin costs an arm and a leg, and for a long time with producing antibody, biological activity reduction, increases dosage and easily produce high islets of langerhans mass formed by blood stasis again, causes the generation of microangiopathies.
2, existing Chinese patent medicine effect is not fairly obvious yet, can only use as ancillary drug, and the patient still has to use heavy dose of Western medicine, as insulin, glyburide, diamicron etc., thereby is difficult to eliminate its side effect.
The objective of the invention is to overcome above-mentioned defective, a kind of Remedies for diabetes with effects such as reducing diabetics blood glucose, glucose in urine, elimination excessive thirst, hepatoprotective, the kidney invigorating, lung moistening, reducing urination, blood pressure lowering, blood circulation promoting and metabolism, anti-multiple pathogenic bacteria poison, enhancing human body immunity power is provided.
Another object of the present invention provides the preparation method of this Remedies for diabetes.
Technical solution of the present invention is according to Traditional Chinese medical theory and modern Chinese medicine achievement in research, in conjunction with the modern diagnosis and treatment theory and practice of diabetes, from the Chinese herbal medicine treasure-house, filter out and have the QI invigorating mind calming, nourshing blood and promoting blood circulation, nourishing YIN to lower pathogenic fire, clearing away heat and promoting production of body fluid, liver and kidney tonifying, lowering blood sugar and preventing thirst, blood pressure lowering, nourishing the liver, the kidney invigorating, lung moistening, the Chinese herbal medicine of effect such as disease-resistant bacterium virus, the one, with wine or its active ingredient of water extraction, simultaneously, for strengthening blood sugar reducing function, improve the curative effect of this medicine, in leaching liquid, add the regulating carbohydrate metabolism of pharmacology dosage and to the nontoxic chromium of human body, selenium, zinc, magnesium, vanadium etc. or wherein any trace element and biochemical adjuvant are made the medicated wine or the decoction of treatment diabetes.The 2nd, add in herbal raw material that auxiliary material such as above-mentioned trace element makes that powder, powder, electuary, tablet, pill, glue are assisted etc. or the medicine of the treatment diabetes of any dosage form wherein.
Medicine components proportioning of the present invention and production method are as follows:
1, medicated wine of the present invention or decoction are made by following proportion raw material:
(1), ethanol content is 0～60% (preferred content is 12～36%, and optimum content is 20～28%) in medicated wine or the decoction
(2), the Chinese herbal medicine proportioning (grams per liter) of leaching in adding wine or the water is as table 1.
Table 1. adds the Chinese herbal medicine proportioning (grams per liter) of leaching in wine or the water
| The Chinese herbal medicine title | Basic proportioning | Optimum ratio | Best proportioning |
| Radix Ginseng | ????3～20 | ????5～12 | ????8～10 |
| The Radix Astragali | ????7～35 | ????10～25 | ????18～22 |
| Fructus Lycii | ????6～30 | ????10～20 | ????15～18 |
| Rhizoma Polygonati | ????7～35 | ????10～25 | ????15～20 |
| Fructus Schisandrae Chinensis | ????3～20 | ????6～12 | ????8～10 |
| Radix Puerariae | ????6～35 | ????10～22 | ????15～18 |
| Flos Lonicerae | ????7～35 | ????10～22 | ????15～18 |
| The Radix Rehmanniae | ????6～30 | ????10～20 | ????12～16 |
| Radix Rehmanniae Preparata | ????6～30 | ????10～20 | ????12～16 |
| Radix Angelicae Sinensis | ????5～30 | ????10～20 | ????10～12 |
| Fructus Rosae Laevigatae | ????5～30 | ????10～20 | ????15～18 |
| The Rhizoma Anemarrhenae | ????3～20 | ????5～15 | ????7～10 |
| Cortex Phellodendri | ????4～20 | ????6～15 | ????7～10 |
(3), trace element addition such as table 2
Table 2 trace element addition
| The trace element title | Basic addition (mg/L) | Preferred addition (mg/L) | Optimal addn (mg/L) |
| Chromium | ????0.1～3 | ????0.3～2.5 | ????0.5～1.5 |
| Selenium | ????0.05～1 | ????0.1～0.6 | ????0.3～0.4 |
| Zinc | ????100～1500 | ????200～1200 | ????300～800 |
| Magnesium | ????50～600 | ????100～500 | ????200～400 |
| Vanadium | ????0.01～0.1 | ????0.015～0.04 | ????0.02～0.03 |
2, powder of the present invention, powder, electuary, pill agent, tablet, glue are assisted etc. and to be made by following proportion raw material.
(1), Chinese herbal medicine proportioning such as table 3.
Table 3. Chinese herbal medicine proportioning (weight proportion)
| The Chinese herbal medicine title | Basic proportioning | Optimum ratio | Best proportioning |
| Radix Ginseng | ????3～20 | ????5～12 | ????8～10 |
| The Radix Astragali | ????7～35 | ????10～25 | ????18～22 |
| Fructus Lycii | ????6～30 | ????10～20 | ????15～18 |
| Rhizoma Polygonati | ????7～35 | ????10～25 | ????15～20 |
| Fructus Schisandrae Chinensis | ????3～20 | ????6～12 | ????8～10 |
| Radix Puerariae | ????6～35 | ????10～22 | ????15～18 |
| Flos Lonicerae | ????7～35 | ????10～22 | ????15～18 |
| The Radix Rehmanniae | ????6～30 | ????10～20 | ????12～16 |
| Radix Angelicae Sinensis | ????5～30 | ????10～20 | ????10～12 |
| Radix Rehmanniae Preparata | ????6～30 | ????10～20 | ????12～16 |
| Fructus Rosae Laevigatae | ????5～30 | ????10～20 | ????15～18 |
| The Rhizoma Anemarrhenae | ????3～20 | ????5～15 | ????7～10 |
| Cortex Phellodendri | ????4～20 | ????6～15 | ????7～10 |
(2), trace element addition such as table 4
Table 4. trace element addition (mg/100g)
| Trace element | Fundamental quantity | Preferred amounts | Optimised quantity |
| Chromium | ????0.01～0.1 | ????0.02～0.08 | ????0.03～0.06 |
| Selenium | ????0.005～0.05 | ????0.006～0.03 | ????0.01～0.03 |
| Zinc | ????10～150 | ????20～100 | ????30～80 |
| Magnesium | ????5～100 | ????10～80 | ????15～50 |
| Vanadium | ????0.001～0.01 | ????0.001～0.005 | ????0.001～0.003 |
3, above-mentioned each component being made the medicated wine of treatment diabetes of the present invention or the production method of decoction is:
(1) adopts conventional method that each flavor herbal raw material is pulverized and be ground to 80～120 order powder, can not the pulverize person all be cut into 0.5～1.5 thin slice.
(2) above-mentioned medicated powder of having processed or tablet are added in wine or the water by described proportioning, stir evenly, the steeping in wine condition is 50～65 ℃ of leachings 1～6 hour, or room temperature leached 8～24 hours.The water logging condition is to be begun to about 94 ℃ (little boiling) leaching 0.5～1.5 hour by room temperature.
(3) with the medicinal liquid vacuum filtration or the filter pressing of above-mentioned leaching.
(4) in above-mentioned filtered medicine liquid, add the trace element solution of concentration known or directly add required stoichiometric trace compound, be stirred to whole dissolvings.
(5) with the above-mentioned medicinal liquid that has added trace element after filtration, sterilize, be up to the standards, pack the medicated wine or the decoction that promptly obtain treatment diabetes of the present invention.
4, powder, powder, electuary, tablet, pill, the glue of described each component being made treatment diabetes of the present invention such as assists to be at the production method of dosage form:
(1) adopt conventional method that each flavor herbal raw material is pulverized after air-dry or lyophilization, is ground to 120～150 order powder, add required stoichiometric trace compound, abundant mixing is made the Chinese medicine preparation of various dosage forms then according to a conventional method.
(2) adopt conventional method that each flavor herbal raw material is pulverized the thin slice that grinds to form 80～120 order powder or be cut into 0.5～1.5mm, water or steeping in wine are got, filter, in leaching liquid, add auxiliary materials such as required stoichiometric trace compound, can obtain the Chinese medicine preparation that electuary of the present invention, powder, tablet, powder, glue such as assist at dosage form spray-dried after the solution concentration.
The medicine of treatment diabetes of the present invention is compared with the medicine of existing treatment diabetes through clinical use result, has the following advantages:
(1) Chinese herbal medicine selected for use of the present invention all meets the pharmaceutical control law regulation with wine and trace element, wherein wine has tangible blood sugar reducing function, trace element also can be regulated carbohydrate metabolism effectively, utilizes the comprehensive function treatment diabetes of wine and each flavor Chinese medicine and trace element, and is nontoxic to human body, have no adverse reaction.
(2) can lowering blood sugar and preventing thirst, again can hepatoprotective, the kidney invigorating, lung moistening, blood pressure lowering, blood circulation promoting and metabolism, human body immunity improving power, prevent multiple disease, reach the effect for the treatment of both the principal and secondary aspects of a disease.
(3) this drug administration convenience, comfortable taste, nutritious, low as the medicated wine ethanol content, taking dose is little, each 40～100 milliliters, all can take after the meal during meal every day 2～3 times, adapt to most diabetic therapy.
(4) this medicine need only be taken separately to the lighter patient of the state of an illness, low dose of chemical sugar-lowering medicine can be added the heavier person of the state of an illness; Because of the detoxifcation maintenance function of Chinese medicine is arranged, also without any side effects.
(5), be more suitable for the patient treatment of general economic condition because of with low cost.
For showing the curative effect of medicine of the present invention to diabetes, the present invention advances system's clinical observation through 50 examples as test group, and selection medical history, the state of an illness, age, sex and 35 suitable routine diabeticss of former Therapeutic Method are matched group: take chemical Antidiabetic Drug (gliquidone and diamicron) routinely, adopt same procedure to make regular check on blood glucose, three months observation periods, a month course of treatment, totally three courses of treatment.
The instructions of taking of medicated wine of the present invention on probation: 50 milliliters/time, 3 time/day, or 75 milliliters/time, 2 times/day, after meal or take during meal, take gliquidone and diamicron 30mg, clinical test results such as table 5 simultaneously every day.
Table 5. is taken medicated wine of the present invention front and back gliquidone, diamicron consumption and change of blood sugar
| Group | Case load | Gliquidone consumption (mg/d) | Diamicron consumption (mg/d) | Fasting glucose (mmol/L) | |||
| Before | After | Before | After | Before | After | ||
| Test group | ????50 | ????120 | ????30 | ????240 | ????30 | ??17.5±2.2 | ??6.1±1.6 |
| Matched group | ????35 | ????120 | ????120 | ????240 | ????240 | ??17.2±1.8 | ??7.6±1.9 |
Show that from table 5 fasting glucose concentration and hypoglycemic medicine consumption are basic identical before two groups of tests, blood glucose dropped to 6.1 by 17.5 after test group was taken medicated wine of the present invention, and gliquidone reduces 75% and 87.5% than former consumption respectively with the diamicron consumption.And matched group is not reducing under the condition of dosage, and fasting glucose can only drop to 7.8 from 17.2.
Also measured simultaneously the relevant data of test diabetic to take medicated wine of the present invention front and back body's immunities, and contrasted result such as table 6, T Lymphocyte Subsets Determination result with the normal person.
Table 6. is taken T Lymphocyte Subsets Determination result behind the medicated wine of the present invention
The method of inspection of T cell subsets is to adopt conventional alkaline phosphorus enzyme alkali resistance phosphoric acid enzyme process, and table 6 testing result shows that diabetics is OKT before taking medicated wine of the present invention
3Be significantly higher than the normal person, OKT
4/ OKT
3Ratio reduces, and takes after the medicated wine of the present invention, and the numerical value that the two reaches the normal person shows that medicated wine of the present invention can significantly increase body's immunity.
Show that according to test statistics with medicated wine of the present invention 50 diabeticss are done therapeutic test, that has obtained significant curative effect accounts for 66%, substantially effectively accounts for 32%, invalid accounts for 2%, and total effective rate accounts for 98%.
Below in conjunction with embodiment medicated wine of the present invention is further described, but is not limitation of the invention.
1, takes by weighing the Chinese liquor and the herbal raw material (kilogram) of ethanol content 26% by following weight proportion
Chinese liquor 50 Flos Loniceraes 1.8
Radix Ginseng 0.5 Radix Rehmanniae 1.5
The Radix Astragali 2.0 Radix Rehmanniaes Preparata 1.5
Structure Qi 1.8 Radix Angelicae Sinensis 1.2
Rhizoma Polygonati 1.8 Fructus Rosae Laevigatae 1.6
Fructus Schisandrae Chinensis 0.9 Rhizoma Anemarrhenae 0.8
Radix Puerariae 1.8 Cortex Phellodendris 0.8
2, with Radix Ginseng, the Radix Astragali, Fructus Schisandrae Chinensis, Radix Puerariae, Flos Lonicerae, the Rhizoma Anemarrhenae, Cortex Phellodendri crushed after being dried to 80～120 day powder.Fructus Lycii, Fructus Rosae Laevigatae are crushed to 80-120 order powder after-15 ℃ of lyophilizations.Rhizoma Polygonati, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis are cut into the thin slice of 0.5～1.5mm.
3, with above-mentioned Chinese medicinal powder and thin slice, under agitation add in the Chinese liquor, leached 4 hours down in 60～66 ℃, be cooled to vacuum filtration below 35 ℃.
4, the trace element solution such as chromium, selenium, zinc, magnesium, vanadium that in the medicated wine of above-mentioned sucking filtration, adds the former concentration known of having prepared respectively, make that chromium is that 1.0mg/L, selenium are that 0.3mg/L, zinc are that 400mg/L, magnesium are that 200mg/L, vanadium are 0.025mg/L in the medicated wine, stir evenly.
5, the above-mentioned medicated wine that has added trace element is made the medicated wine of treatment diabetes of the present invention through ultraviolet radiation sterilization.
Claims (7)
1, a kind of medicine for the treatment of diabetes, it comprises by Chinese herbal medicine and wine and trace element or Chinese herbal medicine and trace element and being formed, it is characterized in that it is the Chinese herbal and crude drugs preparations that contains ethanol or added trace element.
2, the medicine of treatment diabetes according to claim 1 is characterized in that this medicine is that ethanol content is 0～60%, and its preferred content is 12～36%, optimum content is 20～28% medicated wine or decoction.
3, the medicine of treatment diabetes according to claim 1 is characterized in that described Chinese herbal medicine is organized by the following weight proportion raw material:
Radix Ginseng 3～20 Radix Puerariaes 6～35 Fructus Rosae Laevigatae 5～30
The Radix Astragali 7～35 Flos Loniceraes 7～35 Rhizoma Anemarrhenaes 3～20
Fructus Lycii 6～30 Radix Rehmanniae 6～30 Cortex Phellodendris 4～20
Rhizoma Polygonati 7～35 Radix Rehmanniaes Preparata 6～30
Fructus Schisandrae Chinensis 3～20 Radix Angelicae Sinensis 5～30
4, the medicine of treatment diabetes according to claim 1 is characterized in that described trace element is chromium, selenium, zinc, magnesium, vanadium etc. or any element wherein.
5, the medicine of treatment diabetes according to claim 4 is characterized in that described content of elements is: chromium 0.1～3mg/L, selenium 0.05～1mg/L, zinc 100～1500mg/L, magnesium 50～600mg/L, vanadium 0.01～0.1mg/L.
6, the medicine of treatment diabetes according to claim 1, Chinese herbal medicine powder, powder, electuary, tablet, pill, the glue that it is characterized in that adding trace element are assisted etc. or any dosage form wherein.
7, the preparation method of the medicine of the described treatment diabetes of a kind of claim 1, it is characterized in that in the manufacturing process of this medicine in the medicinal liquid of leaching or herbal powder, having added the chromium, selenium, zinc, magnesium, vanadium etc. of concentration known or the solution of any trace element wherein, or directly add required stoichiometric above-mentioned trace compound, micronutrient levels is controlled in the described scope of claim 5.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02113947 CN1435209A (en) | 2002-01-28 | 2002-01-28 | Medicine for treating biabetes and preparing process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02113947 CN1435209A (en) | 2002-01-28 | 2002-01-28 | Medicine for treating biabetes and preparing process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015627B (en) * | 2006-10-20 | 2010-05-12 | 中山大学 | Medicine composition for treating diabetes and its preparation |
| CN102783636A (en) * | 2012-06-04 | 2012-11-21 | 于长富 | Food nutrition supplement for prophylaxis and treatment of diabetes and application thereof |
| CN107898961A (en) * | 2017-12-25 | 2018-04-13 | 东莞市糖扶医药科技有限公司 | It is a kind of to be used to treat plaster, dressing of diabetes and hypertension and preparation method thereof |
-
2002
- 2002-01-28 CN CN 02113947 patent/CN1435209A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015627B (en) * | 2006-10-20 | 2010-05-12 | 中山大学 | Medicine composition for treating diabetes and its preparation |
| CN102783636A (en) * | 2012-06-04 | 2012-11-21 | 于长富 | Food nutrition supplement for prophylaxis and treatment of diabetes and application thereof |
| CN107898961A (en) * | 2017-12-25 | 2018-04-13 | 东莞市糖扶医药科技有限公司 | It is a kind of to be used to treat plaster, dressing of diabetes and hypertension and preparation method thereof |
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