CN101564511A - Natural protein product for treating diabetes and manufacture method - Google Patents
Natural protein product for treating diabetes and manufacture method Download PDFInfo
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- CN101564511A CN101564511A CNA2009100223314A CN200910022331A CN101564511A CN 101564511 A CN101564511 A CN 101564511A CN A2009100223314 A CNA2009100223314 A CN A2009100223314A CN 200910022331 A CN200910022331 A CN 200910022331A CN 101564511 A CN101564511 A CN 101564511A
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Abstract
The invention relates to a natural protein product for treating diabetes and a manufacture method. The natural protein product can effectively prevent the diabetes, and has double efficacies of medicinal diet and food therapy for treating the diabetes. The natural protein product comprises the following raw material medicaments in portion by weight: 8 to 30 portions of honeybee pupa powder, 9 to 45 portions of chitosan powder, 8 to 30 portions of water-soluble propolis powder, 8 to 30 portions of balsam pear powder, 8 to 30 portions of ginseng powder, 8 to 30 portions of corn silk, 8 to 30 portions of glossy ganoderma, 8 to 25 portions of royal jelly freeze-dried powder, 8 to 20 portions of rape flower powder, 2 to 10 portions of natto powder, 2 to 10 portions of medlar, 2 to 10 portions of gallnut, 2 to 10 portions of rhizoma anemarrhenae, 2 to 10 portions of white mulberry root-bark, 2 to 10 portions of trichosanthes root, 5 to 20 portions of cynomorium and 5 to 20 portions of cistanche deserticola. The manufacture method comprises the following steps: crushing the corn silk, the glossy ganoderma, the medlar, the gallnut, the rhizoma anemarrhenae, the white mulberry root-bark, the trichosanthes root, the cynomorium and the cistanche deserticola, then adding the powder into ethanol respectively to leach at room temperature, mixing the leaching liquors, filtering the leaching liquors to obtain filtrate, reclaiming the ethanol till no ethanol smell exists to obtain extract, extracting the extract repeatedly, condensing the extract to thick paste, and drying the thick paste to obtain dry powder; and mixing the dry powder obtained respectively and other components to obtain a powder raw material medicament.
Description
One, technical field:
The present invention relates to a kind of manufacture method of Chinese medicine, especially relate to a kind of native protein goods and manufacture method for the treatment of diabetes.
Two, background technology:
Along with science and technology development with rapid changepl. never-ending changes and improvements, bee product is used among the rehabilitation of diabetics more widely, and be acknowledged as the medicament that has no side effect fully, but existing bee product is the bee glue product of more single composition, it is lower to exist scientific and technological content in various degree, compatibility composition bad adaptability, processed technology fall behind the shortcoming of the multiple requirements such as environmental protection consumption that heavy metal, pesticide residues exceed standard, product function can't satisfy people.
Three, summary of the invention:
The object of the present invention is to provide a kind of native protein goods and manufacture method for the treatment of diabetes, it can effectively prevent diabetes, for the treatment diabetes medicative diet for food therapy health preserving double effects is arranged.
For achieving the above object, the technical solution used in the present invention is:
A kind of native protein goods for the treatment of diabetes, it is characterized in that comprising following crude drug: Pupa Apis powder 8-30, chitosan powder 9-45, water-soluble bee glue powder 8-30, Fructus Momordicae charantiae powder 8-30, Radix Ginseng powder 8-30, Stigma Maydis 8-30, Ganoderma 8-30, Lac regis apis lyophilized powder 8-25, Pollen Brassicae campestris 8-20, natto powder 2-10, Fructus Lycii 2-10, Galla Chinensis 2-10, Rhizoma Anemarrhenae 2-10, Cortex Mori 2-10, Radix Trichosanthis 2-10, Herba Cynomorii 5-20 and Herba Cistanches 5-20, unit of weight is a weight portion.
A kind of manufacture method for the treatment of the native protein goods of diabetes, it is characterized in that: with above-mentioned Stigma Maydis, Ganoderma, Fructus Lycii, Galla Chinensis, the Rhizoma Anemarrhenae, Cortex Mori, Radix Trichosanthis, after Herba Cynomorii and Herba Cistanches are pulverized, 50% ethanol that adds 6 times of amounts respectively carries out the room temperature lixiviate, lixiviate is 4 times altogether, each 12 hours, merge lixiviating solution, filter filtrate, 4 times filtration filtrate merges, reclaim ethanol to do not have alcohol distinguish the flavor of extractum, extractum repeatedly extracts with the ethyl acetate of convention amount after with the water suspendible of 2 times of amounts, till extract was colourless, the combined ethyl acetate extract was concentrated into the thick paste shape, drying gets dry powder; The dry powder that obtains is respectively mixed with other component, get powder raw material medicament.
Compared with prior art, the advantage and the effect that have of the present invention is as follows:
1, monarch, minister in the prescription of the present invention, help, make medicine clear and definite, dosage is accurate.
2, the present invention is beneficial to pharmacology and coordinates and special procure the flavour of a drug compatible combination, and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, principle-method-recipe-medicines are paid attention to biological activity and efficiently utilized, and the specific part of optimized choice medicine is in the hope of optimum medicine efficacy, outstanding key property, and typing rationally, quantitatively.
3, the present invention takes into account science, novelty, feasibility and benefit according to innovative design novel composing prescription in China's Chinese medicine aspect pharmacological effect, adopts modern new technology, new thing source, new device group to become brand-new modern high technology product.
4, the present invention is with reference to the Chinese Pharmacopoeia treating both the principal and secondary aspects of a disease, and scientific composition does not still reach the patient of good controlled target to carrying out reasonable diet treatment and oral hypoglycemic drug therapy; Oral antidiabetic drug secondary inefficacy patient; The diabetes patient that becomes thin who is difficult to typing has waited immunization therapy and auxiliary treatment effect, provides one group of new treatment technology to the rehabilitation of diabetics.
Four, the specific embodiment:
Embodiment:
Pupa Apis powder 8 grams, chitosan powder 10 grams, water-soluble bee glue powder 10 grams, Fructus Momordicae charantiae powder 9 grams, Radix Ginseng powder's 9 grams, Stigma Maydis 9 grams, Ganoderma 8 grams, Lac regis apis lyophilized powder 8 grams, Pollen Brassicae campestris 8 grams, natto powder 3 grams, Fructus Lycii 2 grams, Galla Chinensis 2 grams, the Rhizoma Anemarrhenae 2 grams, Cortex Mori 2 grams, Radix Trichosanthis 2 grams, Herba Cynomorii 5 grams and Herba Cistanches 5 grams.
After above-mentioned Stigma Maydis, Ganoderma, Fructus Lycii, Galla Chinensis, the Rhizoma Anemarrhenae, Cortex Mori, Radix Trichosanthis, Herba Cynomorii and Herba Cistanches pulverizing, 50% ethanol that adds 6 times of amounts respectively carries out the room temperature lixiviate, lixiviate is 4 times altogether, each 12 hours, merge lixiviating solution, filter filtrate, 4 times filtration filtrate merges, reclaim ethanol to do not have alcohol distinguish the flavor of extractum, extractum repeatedly extracts with the ethyl acetate of convention amount after with the water suspendible of 2 times of amounts, till extract is colourless, the combined ethyl acetate extract, be concentrated into the thick paste shape, drying gets dry powder; The dry powder that obtains is respectively mixed with other component, get powder raw material medicament.Powder raw material medicament made comprise pill, suppository, tablet, granule, soft (firmly) capsule preparations, health promoting beverage, medicative diet for food therapy goods.
Pupa Apis powder, chitosan powder, water-soluble bee glue powder, Fructus Momordicae charantiae powder, Radix Ginseng powder, Lac regis apis lyophilized powder, Pollen Brassicae campestris and natto powder all adopt existing commercially available prod in the said components.
Product of the present invention sugar capsule for eliminating is to the influence of experimental hyperglycemia model mice blood glucose:
1, experiment purpose: observe the influence of product sugar capsule for eliminating of the present invention, to determine curative effect to experimental hyperglycemia model mice blood glucose.
2, experiment reagent: alloxan; The blood sugar detection medicine box.
3, experimental animal: 20-25 restrains Kunming mouse, the male and female dual-purpose, and Xi'an Jiaotong University Medical College's Experimental Animal Center provides.
4, test method: get body weight 20-25 gram Kunming mouse, fasting be can't help water after 24 hours, and lumbar injection alloxan 200 mg/kg cause the experimental hyperglycemia model.The injection alloxan is after 72 hours, and mouse orbit is got blood and surveyed blood glucose.Choose the mice of blood glucose greater than 10mmol/L, be divided into model group and sugared capsule for eliminating high and low dose group, every group of 22-26 only presses the 0.2ml/10g body weight and irritates stomach, and the high and low dose group is respectively 5g/kg, 10g/kg, and model group is given same water gaging.Once a day, continuous 14 days, the 15 day mouse orbit got blood and surveyed blood glucose, calculates the mouse blood sugar average, with t check carrying out statistical analysis, relatively administration front and back and group difference.
5, experimental result: sugared capsule for eliminating can obviously reduce the blood glucose value of experimental hyperglycemia model mice with the model group comparison under 5g/kg, 10g/kg dosage, with the blood glucose value that relatively can obviously reduce the experimental hyperglycemia model mice before the administration.
The sugared capsule for eliminating of table 1 is to the influence (X=SD) of the blood glucose value of experimental hyperglycemia model mice
Δ (comparing P＜0.001) with model group
* (with comparing P＜0.05 before the administration)
Each user report by statistics, its conclusion is: " hypoglycemic capsule " has blood sugar lowering, health care's effect, to treatment diabetic syndrome determined curative effect, significantly, obviously is better than other medicines." treatment diabetes effective percentage 91.33%, the treatment congenital heredity or the day after tomorrow effective percentage reach 94.73%, 90.38% respectively, treatment is not seen toxic and side effects because of the urine sugar value rising effective percentage 99.11% that diet causes.
Table 2 hypoglycemic capsule is used the curative effect statistical table
X＝121.60 X＝21.73 X＝15.18
P≤0.005 p＜0.005 p＜0.005
1. it is effective to cure 2. produce effects 3.
Clinical effectiveness
1, Mrs Qi, 52 years old.The thirsty polydipsia of patient, the food polyuria is many, and is long clearly when urine is just separated, after become little yellow gradually, whole body pain, lethargy, body and face edema, the heating spontaneous perspiration, it is unable to feel during action to breathe hard.Thready pulse moistens, and body of the tongue is thick, and tongue fur is covered with white greasy, and the dry crape of body of the tongue presents dark yellow during color of the lip is purplish red.Check: the blood glucose height, glucose in urine (+++).Be diagnosed as diabetes.
According to every 0.36 of granule of design gram, take every day 2 times each 2 take medicine after, the patient is thirsty to weaken, symptom is clearly better.Glucose in urine transfers (+) to, and the urine color is normal, and edema disappears, and body of the tongue is recovered, and obviously improving appears in mental status.
2, Mr. Guo, 55 years old, the many famines of polyphagia, thirsty polydipsia, frequent micturition, frequent micturition, dizziness can not be adhered to work.Obviously descend red tongue, yellow and thin fur, thready and rapid pulse before body weight is sick.The chemical examination glucose in urine (+++).
Though insulin injection treatment once, though symptom has alleviation, often outbreak repeatedly.After the top of migrating take, according to every 0.36 of granule of design gram, take every day 2 times each 2 take medicine after, check glucose in urine (+-), diet often begins to become a full member, being clearly better appears in above-mentioned symptom, and the work of having gone to work.
3, Mrs Bai, 35 years old, thirsty polydipsia during beginning, urinary micturition, appetite surge, menoxenia.Back health begins to become thin gradually, and the extremity sleepiness is unable, and menstruation stops, the deep pulse number, and red tongue, the little Huang of thin fur is hard and dry.Laboratory examination is a diabetic syndrome, and urine sugar value is (++).
According to every 0.36 of granule of design gram, take every day 2 times each 2 take medicine after, thirsty phenomenon is gradually separated, amount of drinking water reduces day by day, examination of sugar in urine (+), after keeping former side and continuing to take, thirsty phenomenon disappears, stomach is received and is urinated and all recover normal, glucose in urine (-).Weight increase, menstruation begin normally, and extremity are strong, can work.
Claims (2)
1, a kind of native protein goods for the treatment of diabetes, it is characterized in that comprising following crude drug: Pupa Apis powder 8-30, chitosan powder 9-45, water-soluble bee glue powder 8-30, Fructus Momordicae charantiae powder 8-30, Radix Ginseng powder 8-30, Stigma Maydis 8-30, Ganoderma 8-30, Lac regis apis lyophilized powder 8-25, Pollen Brassicae campestris 8-20, natto powder 2-10, Fructus Lycii 2-10, Galla Chinensis 2-10, Rhizoma Anemarrhenae 2-10, Cortex Mori 2-10, Radix Trichosanthis 2-10, Herba Cynomorii 5-20 and Herba Cistanches 5-20, unit of weight is a weight portion.
2, a kind of manufacture method for the treatment of the native protein goods of diabetes according to claim 1, it is characterized in that: with above-mentioned Stigma Maydis, Ganoderma, Fructus Lycii, Galla Chinensis, the Rhizoma Anemarrhenae, Cortex Mori, Radix Trichosanthis, after Herba Cynomorii and Herba Cistanches are pulverized, 50% ethanol that adds 6 times of amounts respectively carries out the room temperature lixiviate, lixiviate is 4 times altogether, each 12 hours, merge lixiviating solution, filter filtrate, 4 times filtration filtrate merges, reclaim ethanol to do not have alcohol distinguish the flavor of extractum, extractum repeatedly extracts with the ethyl acetate of convention amount after with the water suspendible of 2 times of amounts, till extract was colourless, the combined ethyl acetate extract was concentrated into the thick paste shape, drying gets dry powder; The dry powder that obtains is respectively mixed with other component, get powder raw material medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100223314A CN101564511B (en) | 2009-05-05 | 2009-05-05 | Natural protein product for treating diabetes and manufacture method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100223314A CN101564511B (en) | 2009-05-05 | 2009-05-05 | Natural protein product for treating diabetes and manufacture method |
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| Publication Number | Publication Date |
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| CN101564511A true CN101564511A (en) | 2009-10-28 |
| CN101564511B CN101564511B (en) | 2012-05-09 |
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| CN2009100223314A Expired - Fee Related CN101564511B (en) | 2009-05-05 | 2009-05-05 | Natural protein product for treating diabetes and manufacture method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308990A (en) * | 2011-07-19 | 2012-01-11 | 南宁大单生物科技有限责任公司 | Bitter gourd and Chinese caterpillar fungus and ganoderma lucidum powder |
| CN108938778A (en) * | 2018-08-29 | 2018-12-07 | 李开国 | A kind of Chinese herbal medicine formula for treating hypertension and diabetes |
| CN109259092A (en) * | 2017-07-17 | 2019-01-25 | 山西怡康德盛生物科技有限公司 | A kind of food and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1569216A (en) * | 2004-04-27 | 2005-01-26 | 武兴战 | Nanometer natural biological protein bee product and its preparation |
| CN1981783A (en) * | 2005-12-16 | 2007-06-20 | 武兴战 | Nano-bee productf for adjusting immune function and its production |
| CN101088518A (en) * | 2006-06-13 | 2007-12-19 | 武兴战 | Medicine prepn for reducing blood sugar and regulating blood pressure |
-
2009
- 2009-05-05 CN CN2009100223314A patent/CN101564511B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308990A (en) * | 2011-07-19 | 2012-01-11 | 南宁大单生物科技有限责任公司 | Bitter gourd and Chinese caterpillar fungus and ganoderma lucidum powder |
| CN109259092A (en) * | 2017-07-17 | 2019-01-25 | 山西怡康德盛生物科技有限公司 | A kind of food and preparation method thereof |
| CN108938778A (en) * | 2018-08-29 | 2018-12-07 | 李开国 | A kind of Chinese herbal medicine formula for treating hypertension and diabetes |
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| Publication number | Publication date |
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| CN101564511B (en) | 2012-05-09 |
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