CN107898961A

CN107898961A - It is a kind of to be used to treat plaster, dressing of diabetes and hypertension and preparation method thereof

Info

Publication number: CN107898961A
Application number: CN201711420581.4A
Authority: CN
Inventors: 黎驰
Original assignee: Dongguan Sugar Fu Pharmaceutical Science And Technology Co Ltd
Current assignee: Dongguan Sugar Fu Pharmaceutical Science And Technology Co Ltd
Priority date: 2017-12-25
Filing date: 2017-12-25
Publication date: 2018-04-13

Abstract

The invention discloses a kind of plaster, dressing for being used to treat diabetes and hypertension and preparation method thereof, which is boiled and is formed by extract alcoholic solution, active compound powder, vaseline, borneol and camphor；The extract alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and crude drug includes：Monarch drug in a prescription：Ginseng, radix astragali, ministerial drug：Sealwort, the coptis, peach kernel, Angelica sinensis, Chinese cassia tree, flos caryophylli, asarum, galangal, the root bark of tree peony, adjutant：Dried peppermint leaf, muscone；Active compound powder is pulverized and mixed to obtain by above-mentioned crude drug according to above-mentioned formula rate.The plaster of the present invention is externally applied drug, is prepared easy, it then follows tcm prescription principle of medication, according to clinical verification, blood glucose and blood pressure can be reduced, reaches the effect for the treatment of diabetes and hypertension, improve because diabetes cause syndrome, improve the immune function of body, it is evident in efficacy, mild in medicine property and, do not occur toxic side effect, there is fat-reducing effect, and can be pasted by dressing mode, it is easy to use, not soiled clothes.

Description

It is a kind of to be used to treat plaster, dressing of diabetes and hypertension and preparation method thereof

Technical field

The present invention relates to technical field of pharmaceuticals, more specifically, is related to a kind of for treating diabetes and hypertension Plaster, dressing and preparation method thereof.

Background technology

Diabetes are a kind of common frdquently encountered diseases, and high risks are formed to the health of people.Diabetes (diabetesmellitus, DM) is due to that different reasons cause defect of insulin secretion and (or) insulin action defect to cause Sugar, protein, fat metabolism are abnormal, the disease using chronic hyperglycemia as outstanding behaviours.Clinical manifestation is diuresis, more drink, more foods, Become thin, can the concurrent tissue such as eye, kidney, nerve, heart, blood vessel chronic injury, the acute metablize confusion can occur when being in a bad way, Such as ketoacidosis, hyperosmolar coma.At present, the treatment of diabetes is using Western medicine hypoglycemic as main treatment means, but controls Easily occur complication during treatment, and long-term use of Western medicine to other organs there is a great harm for, in addition, current diabetes are controlled It is type for oral administration to treat medicine, and external curing medicine is comparatively also in space state.For correlation existing in the prior art Technical problem, not yet proposes effective solution at present.

The content of the invention

It is an object of the invention to overcome drawbacks described above of the prior art, there is provided a kind of evident in efficacy, mild in medicine property and, nothing Side effect be used for treat plaster, dressing of diabetes and hypertension and preparation method thereof.

To achieve the above object, the first aspect of the present invention provides a kind of cream for being used to treat diabetes and hypertension Medicine, the plaster by 2800ml~3200ml extracts alcoholic solution, 8kg~12kg active compounds powder, 8kg~10kg vaseline, 28g~ 32g borneols and 28g~32g camphors are boiled and formed；

Wherein, the extract alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, the active compound Material includes：Monarch drug in a prescription：Ginseng 10g~30g, radix astragali 30g~60g, ministerial drug：Sealwort 10g~20g, coptis 1g~5g, peach kernel 5g~ 10g, Angelica sinensis 1g~5g, Chinese cassia tree 1g~5g, flos caryophylli 1g~5g, asarum 0.5g~1g, galangal 1g~5g, root bark of tree peony 1g~5g, Adjutant：Dried peppermint leaf 1g~2g, muscone 0.5g~1g；

The active compound powder is pulverized and mixed to obtain by above-mentioned crude drug according to above-mentioned formula rate.

As preference, in the technical solution of above-mentioned plaster, the ministerial drug in the crude drug further includes：Cortex Phellodendri 1g~ 5g, dried rhizome of rehmannia 10g~20g, evodia rutaecarpa 1g~3g, Radix Salviae Miltiorrhizae 1g~5g, root of Chinese trichosanthes 1g~5g.

As preference, in the technical solution of above-mentioned plaster, the medicinal alcohol is arranged to the medical wine of 95% concentration Essence.

As preference, in the technical solution of above-mentioned plaster, the mesh number of the active compound powder is the mesh of 80 mesh~120.

The second aspect of the present invention provides a kind of dressing for being used to treat diabetes and hypertension, including base material, stickup Layer and cream bed course, the adhered layer are set on the surface of the substrate, and the cream bed course is arranged on the surface of adhered layer, the cream Bed course is equipped with Claims 1 to 4 the plaster for being used to treat diabetes and hypertension described in any one.

As preference, in the technical solution of above-mentioned dressing, the base material is arranged to non-woven fabrics, and the adhered layer is set For pressure sensitive adhesive, the cream bed course is arranged to the water absorption pad containing cotton and viscose glue.

The third aspect of the present invention provides a kind of preparation method for the plaster for being used to treat diabetes and hypertension, including Following steps：

(1) crude drug is added to medicinal alcohol to soak 50~70 days, extracts effective liquid component, obtained 2800ml~ 3200ml extract alcoholic solutions, wherein, the crude drug includes：Monarch drug in a prescription：Ginseng 10g~30g, radix astragali 30g~60g, ministerial drug： Sealwort 10g~20g, coptis 1g~5g, peach kernel 5g~10g, Angelica sinensis 1g~5g, Chinese cassia tree 1g~5g, flos caryophylli 1g~5g, asarum 0.5g~1g, galangal 1g~5g, root bark of tree peony 1g~5g, adjutant：1g~2g dried peppermint leaves, 0.5g~1g muscones；

(2) separately take more parts of crude drugs to be mixed into powder according to above-mentioned formula rate dries pulverizing, and therefrom weigh 8kg~ 12kg active compound powder；

(3) 8kg~12kg active compound powder is added among 8kg~10kg vaseline, adds 2800ml~3200ml and carry Thing alcoholic solution, 28g~32g borneols and 28g~32g camphors are taken, is brewed into dark brown lotion.

As preference, in the above-mentioned methods, the ministerial drug in every part of crude drug of the step (1) and step (2) also wraps Include：Cortex Phellodendri 1g~5g, dried rhizome of rehmannia 10g~20g, evodia rutaecarpa 1g~3g, Radix Salviae Miltiorrhizae 1g~5g, root of Chinese trichosanthes 1g~5g.

As preference, in the above-mentioned methods, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, the active compound The mesh number of powder is the mesh of 80 mesh~120.

As preference, in the above-mentioned methods, the temperature that boils is described to boil the time and be for 100 DEG C~150 DEG C 30min~40min.

In formula, the pharmacological effect of each component is summarized as follows：

Ginseng, is the root of Araliaceae ginseng.It is sweet in flavor, temperature, be slightly cold, smell it is all light, can rise to drop, sun in have the moon, It is nontoxic.It is the panacea of tonifying Qi, the spirit seedling of living person.Ginseng or ginsenoside have corrective action to abnormal blood glucose, can improve Hypoglycemia, reduces hyperglycaemia.Ginseng extract, panaxan, ginseng polypeptide, gen-seng haulms polysaccharide, the non-saponin fraction of ginseng are equal There is hypoglycemic.This product sweet and slightly bitter taste and slightly warm in nature, are apt to the gas of tonifying five zang organs, tonifying Qi and and can yin-nourishing, keep without walking；Radix astragali is apt to Fleshy exterior is walked, tonifying Qi is simultaneous to help sun, walk without keeping.Two medicine phases must match, and have the function that powerful tonifying Qi is supporing yang, and the two one is walked Keep, reinforce vital energy, promoting vital essence and blood genernation, negative and positive are taken into account, out and out, and logical nothing of mending is rushed down.Deficient QI of the spleen and stomach person, with gas in inspiration, is reached with it with adjusting Three is burnt, and weak person helps arteries and veins to the deficiency syndrome of the lung with tonifying Qi Gu Wei, the heart qi deficiency person of dispelling with bushing.The not dry help spleen and lung of ginseng sweet temperature, helps transporting, defeated Precise and tiny, cloth sperm, makes gas Wang Jinsheng, with the effect quenched the thirst up to nourishing generate fluid, and controls injury thirst, the card that abnormal heat is quenched one's thirst.

Radix astragali, is the root of legume astragalus mongolicus.It is sweet in flavor, tepor, returns spleen, lung channel.Effect：Tonifying Qi and lifting yang, benefit are defended solid Table, inducing diuresis for removing edema, torr sore myogenic, for treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency is certainly Sweat, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.Film pod is yellow Contain astragalin (I.II), daucosterol, cupreol, palmitic acid, sucrose, Astragalus membranacus glycosides and astragalin in stilbene root.Astragalus polyose It is that there is the standby sugar of two-way conciliation section.Radix astragali can promote RNA and albumen to synthesize, increase mouse and tissue cyclic nucleotide Content, reduces hyperglycaemia, raises hypoglycemia, reduces the effect such as blood fat, there is significant protective effect, astragaloside to cardiac muscle cell Energy anti-arrhythmia, coronary artery dilator and peripheral blood vessel, reduce blood pressure, and improve anaemia animal blood as reducing platelet adhesion reaction Rate, reduces thrombosis.Raw radix astragali energy tonifying Qi is promoted the production of body fluid, and controls deficiency of vital energy body fluid deficiency, the card of Heat Diabetes, card is shown in the deficiency of Yin for this, scorching to be Mark, hinders Tianjin gas consumption.Often with the condition 5 of the nourishing Yin and clearing heat such as ginseng, dried rehamnnia root, rhizoma anemarrhenae, root of Chinese trichosanthes.

Sealwort, it is sweet in flavor, it is mild-natured.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Weakness of the spleen and the stomach for treating, body is tired It is weak, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, the disease such as Heat Diabetes.There are anti anoxia, antifatigue, anti-aging effects；It can increase Strong immune function, enhancing metabolism；There is hypoglycemic and cardiac effect, it is very effective in cure for diabetes.

The coptis, the coptis, for the rhizome of the ranunculaceae plant coptis, the triangle leaf coptis, coptis omeiensis or rhizoma coptidis teetoidis.Hardship, trembles with fear. The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, height are vomitted Hot coma, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache, quenches one's thirst, carbuncle swells furunculosis；Control eczema, wet sore, duct outside Suppurate.This product long term usage injuring spleen-stomach, deficiency-cold in spleen and stomach person avoid clothes.Again it is bitter it is dry hinder Tianjin, deficiency of Yin Tianjin the wounded also careful clothes.

Peach kernel, the dry mature seed of rosaceous plant peach.Harvested after fruit maturation, remove pulp and nucleocapsid, take out kind Son, is dried.Generally cultivate all parts of the country.With promoting blood circulation, relax bowel, it is relieving cough and asthma the effect of.For closed dysmenorrhea, lump in the abdomen Lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.

Angelica sinensis, nature and flavor：It is sweet, pungent, warm.With blood-supplementing blood-nourishing, menstruction regulating and pain relieving is moisturize laxation, anticancer, anti-ageing anti-old, immune The effect of.Major function：Enrich blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.The main all cards of the deficiency of blood；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Disease Lump in the abdomen knot gathers；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Numbness；Intestines are dry and shit is difficult；Weight after dysentery characterized by blood in the stool；Ulcer sores；Injury from falling down；Can expansion Blood vessel, reduces blood pressure；It is hypoglycemic.

Chinese cassia tree, function：Control the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, abdominal pain diarrhea, cold hernia run quickly globefish, waist and knee crymodynia, warp It is floating more to close abdominal mass, cloudy subcutaneous ulcer, streamer, and empty sun, heat in the upper and cold in the lower.Cure mainly：For impotence, Gong Leng, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, warp Close, dysmenorrhoea, warming meridians and promoting circulation of qi.For the elderly's insufficiency of the kidney yang, aversion to cold and cold limbs, hypoactivity of spleen-YANG, coldness and pain in the epigastrium, deficiency of food loose stool, complete paddy The disease such as do not change.Blood glucose balance can be controlled, prevents and treats diabetes, there is antihypertensive effect.

Flos caryophylli, it is acrid in flavour and warm in nature.Returns spleen, stomach, lung, kidney channel.Fear Radix Curcumae.Inverse, eliminating cold to stop pain, warming kidney and enhancing yang drop in middle benefit gas.Pharmacology is made With：Cloves is aromatic stomachic, can alleviate abdominal bloating, increases gastric secretion, strengthens digestion power, mitigates nausea and vomiting, water Decoction has inhibitory action to staphylococcus, streptococcus, Escherichia coli, typhoid bacillus, Pseudomonas aeruginosa etc..Cure mainly：Vomit for stomach cold Spit, hiccup, can also control pernicious vomiting.For stomach cold coldness and pain in the epigastrium.For impotence, uterus cold infertile.

Galangal, enters taste warp, effect and effect：It is similar to rhizoma zingiberis, there are dispelling cold, stomach invigorating and analgesic activity, but rhizoma zingiberis is dispelled Cold power is larger, and then analgesic activity is stronger for galingal.In vitro test again has antibacterial action to hemolytic streptococcus etc..Cure mainly：Chilly is made Bitterly, vomits gas.

The root bark of tree peony, the root bark of tree peony, also known as moutan bark, contained paeonol and its glucosides constituents in addition have anti-inflammatory effect；Tree peony The methanolic extract of skin has suppression Platelet；Paeonol has the central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolysis And the effect such as antiatherosclerosis, diuresis, antiulcer.Clearing heat and cooling blood；Promoting blood circulation to remove blood stasis.Warm heat disease heat invading xuefen；Send out spot；Spit Nosebleed；Pyreticosis later stage hot Fu Yin distributions heat；Deficiency of Yin osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhoea；Carbuncle sore tumefacting virus；The pain of injury caused by falling and tumbling；Rheumatic fever Numbness.

Dried peppermint leaf, is the leaf of plant peppermint, and taste is refrigerant, have luxuriant lotus leaf, jintan grass, rising Yang grass, Bu He title it is thin Lotus, mainly containing the composition such as peppermint oil, menthol and menthones, isomenthone, Rosmarinic acid.Can be with stomach invigorating wind-dispelling, eliminating the phlegm, profit Courage, anti-spasm, improve sense Mao fevers, throat, swelling and pain, and eliminate headache, toothache, nausea sense.It is also commonly used for making cooking or sweet tea Point, to remove fish and mutton fishy smell, or collocation fruit and dessert, to render palatable；It may be alternatively configured the lotion of anti-inflammation detumescence.

Muscone, has the effect such as resuscitation with aromatics, degrading the channel, swelling and pain relieving, energy coronary artery dilator, and antianginal is made With approximate with nitroglycerin.

Cortex Phellodendri, bark internal layer are used as medicine after processing.Bitter, it is cold in nature.It is clearing heat and detoxicating, purging intense heat eliminating dampness.Cure mainly acute bacterial The inflammation such as dysentery, chordapsus, acute icteric hepatitis, urinary system infection contamination.Burning hot wound, tympanitis, acute conjunctiva are controlled in external application Inflammation, damp-heat dysentery, diarrhea, jaundice；Under nocturnal emission, stranguria with turbid discharge, band；Hectic fever due to yin labor heat, night sweat；And aphthae；Red eye, swell pain；Ulcer Sore；Skin eczema.

The dried rhizome of rehmannia, channel tropism：The heart channel of Hang-Shaoyin；Liver Channel；Kidney channel.Function：Clearing heat and cooling blood；Fluid dryness cures mainly：Acute fever；High fever god Dusk；Macula；Hinder polydipsia in Tianjin；The haematemesis of blood-heat bleeding；Bleeding from five sense organs or subcutaneous tissue；Uterine bleeding；Have blood in stool；Aphthae；Abscess of throat；Labor heat cough；Fall Injure pain；Carbuncle swells.There are hypoglycemic, decompression, hemostasis, diuresis, anti-inflammatory effect.

Evodia rutaecarpa, is used as medicine with ripening fruits, acrid flavour, hardship, big heat.Energy warming spleen and stomach for dispelling cold analgesic, stopping nausea and vomiting by lowering the adverse flow of QI；Cure mainly：Gastral cavity abdomen The diseases such as cold pain, gastrofrigid vomiting.Eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For jueyin headache, cold hernia stomachache, the disturbance of lower legs due to pathogenic cold and dampness, Dysmenorrhoea, dysmenorrhea, abdominal distention, vomits acid regurgitation, Diarrhoea, controls aphtha outside；Hypertension.

Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, for the drying root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter, cold nature, converge to heart and liver channels.There is blood-nourishing The effect of promoting blood circulation, invigorate blood circulation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire.Radix Salviae Miltiorrhizae contains fat-soluble two circles quinones and water-soluble phenolic Property compound, such as tanshinone, dihydrotanshinone.This product work(arrogates to oneself promoting blood circulation, and property is more gentle, and energy removing blood stasis for promoting tissue regeneration is without hindering Just.

Root of Chinese trichosanthes, is the root of cucurbitaceous plant snakegourd.Nature and flavor are sweet, and slight bitter, is slightly cold, and attach to the lung and stomach meridians.Have heat-clearing, promote the production of body fluid, only Yearningly, moisturize, the effect of apocenosis, detumescence.It is kind to control yearningly and its property is sweet to tremble with fear, control void yearningly from tonic, fire is controlled yearningly from the medicine of a cold nature, from Gas medicine and control strongly fragrant thirsty, control polydipsia from blood medicine, be to control thirsty key medicine.Contain saccharide compound in radices trichosanthis, have and significantly exempt from Epidemic disease adjustment effect, has a significant antitumor and cytotoxic activity, polysaccharide mainly have glucose, breast augmentation sugar, fructose, mannitol, Xylose and a small amount of protein composition；Still contain trace element manganese.Research has shown that the hypoglycemic active ingredient of root of Chinese trichosanthes is a kind of sugared egg In vain, Plant lectins compound is belonged to, therefore referred to as root of Chinese trichosanthes coagulates element.In vitro test proves to have Anti-lipolytic and promotes fat Fat synthesizes and insulin-like effects.

Borneol, acrid flavour, hardship, is slightly cold；The thoughts of returning home, liver, lung channel；Delicate fragrance a surname dissipate, has inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison, and improving eyesight is moved back The effect of screen, cure mainly high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, apoplexy coma due to blocking of the respiratory system shies epilepsy, summer-heat and damp blinds clear key, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites Hemorrhoid, red eye, swell pain, pterygium.

Camphor, is the branch, dry, leaf and root of canella camphor tree, through crystalline particulate made from refinement.Camphor has clearance Key, qi stagnation removing, ward off the effect of foul, desinsection is antipruritic, swelling and pain relieving, cures mainly the symptoms such as mange itch, injuries from falls as well, toothache.

Compared with prior art, the beneficial effects of the present invention are：

1st, plaster of the invention is externally applied drug, is boiled by extract alcoholic solution, active compound powder, vaseline, borneol and camphor Form, using ginseng, radix astragali as monarch drug in a prescription in medicinal material, tonifying Qi is promoted the production of body fluid, and is reinforced vital energy, supplementing qi and nourishing yin, sealwort, the coptis, peach kernel, Angelica sinensis, Chinese cassia tree, flos caryophylli, asarum, galangal, the root bark of tree peony are ministerial drug, and kidney-yang nourishing is promoting blood circulation and removing obstruction in channels, relaxes bowel, dried peppermint leaf, muscone There is synergistic therapeutic action for adjutant, resuscitation with aromatics, degrading the channel, swelling and pain relieving, monarch, minister, three medical instruments of assistant, borneol and camphor can draw Medicine enters skin, easy to absorption of human body, verifies by clinic application, it can reduce blood glucose and blood pressure, reaches treatment diabetes and hypertension Effect, improve headache, thirsty, fatiguability, hand fiber crops, visual impairment, constipation, frequent micturition, sex dysfunction caused by diabetes Etc. various syndromes, improve the immune function of body, evident in efficacy, the medicine of a warm nature and cold medicine condition each other in side, mild in medicine property and, not There is toxic side effect, there is certain fat-reducing effect.

2nd, plaster of the invention can be pasted onto at the human bodies such as navel, Yongquan acupoint by dressing mode, easy to use, Dosage is few, and patch acupuncture point is accurate, and firm pasting, soiled clothes, not evident in efficacy, very by the favorable comment of patient, have medicine for oral administration and its The advantages of his externally applied drug is incomparable.

3rd, the preparation of plaster of the invention is easy, and medicine source is wide, it then follows the prescriptions principle of the traditional Chinese medical science.

Brief description of the drawings

In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing There is attached drawing needed in technology description to be briefly described, it should be apparent that, drawings in the following description are the present invention Some embodiments, for those of ordinary skill in the art, without creative efforts, can also basis These attached drawings obtain other attached drawings.

Fig. 1 is a kind of structure diagram of dressing for being used to treat diabetes and hypertension provided by the invention；

Fig. 2 is a kind of Rotating fields figure of dressing for being used to treat diabetes and hypertension provided by the invention.

Embodiment

To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention In attached drawing, the technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is Part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art All other embodiments obtained without creative efforts, belong to the scope of protection of the invention.

Embodiment 1

The embodiment of the present invention 1 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 2800ml Extract alcoholic solution, 8kg active compounds powder, 8kg vaseline, 28g borneols and 28g camphors are boiled and formed；Wherein, the wine with extract Smart solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 10g, radix astragali 30g, ministerial drug：Sealwort 10g, coptis 1g, peach kernel 5g, Angelica sinensis 1g, Chinese cassia tree 1g, flos caryophylli 1g, asarum 0.5g, galangal 1g, the root bark of tree peony 1g, adjutant：Dried peppermint leaf 1g, muscone 0.5g；The active compound powder is pulverized and mixed by above-mentioned crude drug according to above-mentioned formula rate Obtain.

The preparation method of above-mentioned plaster comprises the following steps：

(1) crude drug is added to medicinal alcohol to soak 50 days, extracts effective liquid component, 2800ml wine with extract is made Smart solution；

(2) more parts of crude drugs (reconfiguring) are separately taken to be mixed into powder according to above-mentioned formula rate dries pulverizing, and therefrom Weigh 8kg active compound powder；

(3) 8kg active compound powder is added among 8kg vaseline, adds 2800ml extracts alcoholic solution, 28g borneols With 28g camphors, dark brown lotion is brewed into.

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 80 mesh, the temperature that boils is 100 DEG C, and described to boil the time be 30min.

Embodiment 2

The embodiment of the present invention 2 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 3000ml Extract alcoholic solution, 10kg active compounds powder, 8kg vaseline, 30g borneols and 30g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 20g, radix astragali 40g, ministerial drug：Sealwort 15g, coptis 2g, peach kernel 6g, Angelica sinensis 3g, Chinese cassia tree 2g, flos caryophylli 2g, asarum 0.7g, galangal 2g, the root bark of tree peony 3g, adjutant：Dried peppermint leaf 1g, muscone 0.6g；The active compound powder is pulverized and mixed by above-mentioned crude drug according to above-mentioned formula rate Obtain.

(1) crude drug is added to medicinal alcohol to soak 60 days, extracts effective liquid component, 3000ml wine with extract is made Smart solution；

(2) separately take more parts of crude drugs to be mixed into powder according to above-mentioned formula rate dries pulverizing, and therefrom weigh 10kg originals Medicinal powder；

(3) 10kg active compound powder is added among 8kg vaseline, adds 3000ml extracts alcoholic solution, 30g borneols With 30g camphors, dark brown lotion is brewed into.

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 80 mesh, the temperature that boils is 120 DEG C, and described to boil the time be 30min.

Embodiment 3

The embodiment of the present invention 3 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 3000ml Extract alcoholic solution, 10kg active compounds powder, 8kg vaseline, 30g borneols and 30g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 25g, radix astragali 50g, ministerial drug：Sealwort 18g, coptis 4g, peach kernel 8g, Angelica sinensis 4g, Chinese cassia tree 3g, flos caryophylli 4g, asarum 0.8g, galangal 3g, the root bark of tree peony 3g, adjutant：Dried peppermint leaf 2g, muscone 0.8g；The active compound powder is pulverized and mixed by above-mentioned crude drug according to above-mentioned formula rate Obtain.

(1) crude drug is added to medicinal alcohol to soak 65 days, extracts effective liquid component, 3000ml wine with extract is made Smart solution；

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 100 mesh, the temperature that boils is 135 DEG C, and described to boil the time be 35min.

Embodiment 4

The embodiment of the present invention 4 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 3200ml Extract alcoholic solution, 12kg active compounds powder, 10kg vaseline, 32g borneols and 32g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 30g, radix astragali 60g, ministerial drug：Sealwort 20g, coptis 5g, peach kernel 10g, Angelica sinensis 5g, Chinese cassia tree 5g, flos caryophylli 5g, asarum 1g, galangal 5g, the root bark of tree peony 5g, adjutant：Dried peppermint leaf 2g, muscone 1g；The active compound powder is pulverized and mixed by above-mentioned crude drug according to above-mentioned formula rate Arrive.

(1) crude drug is added to medicinal alcohol to soak 70 days, extracts effective liquid component, 3200ml wine with extract is made Smart solution；

(2) separately take more parts of crude drugs to be mixed into powder according to above-mentioned formula rate dries pulverizing, and therefrom weigh 12kg originals Medicinal powder；

(3) 12kg active compound powder is added among 10kg vaseline, adds 3200ml extracts alcoholic solution, 32g ice Piece and 32g camphors, are brewed into dark brown lotion.

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 120 mesh, the temperature that boils is 150 DEG C, and described to boil the time be 40min.

Embodiment 5

The embodiment of the present invention 5 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 2900ml Extract alcoholic solution, 10kg active compounds powder, 9kg vaseline, 30g borneols and 30g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 11g, radix astragali 45g, ministerial drug：Sealwort 15g, coptis 3g, peach kernel 7g, Angelica sinensis 4g, Chinese cassia tree 3g, flos caryophylli 3g, asarum 0.8g, galangal 3g, the root bark of tree peony 3g, Cortex Phellodendri 3g, dried rhizome of rehmannia 15g, evodia rutaecarpa 2g, Radix Salviae Miltiorrhizae 3g, root of Chinese trichosanthes 1g, adjutant：Dried peppermint leaf 1g, muscone 0.5g；The original Medicinal powder is pulverized and mixed to obtain by above-mentioned crude drug according to above-mentioned formula rate.

(1) crude drug is added to medicinal alcohol to soak 60 days, extracts effective liquid component, 2900ml wine with extract is made Smart solution；

(3) 10kg active compound powder is added among 9kg vaseline, adds 2900ml extracts alcoholic solution, 30g borneols With 30g camphors, dark brown lotion is brewed into.

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 80 mesh, the temperature that boils is 110 DEG C, and described to boil the time be 30min.

Embodiment 6

The embodiment of the present invention 6 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 3000ml Extract alcoholic solution, 10kg active compounds powder, 8kg vaseline, 30g borneols and 30g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 25g, radix astragali 50g, ministerial drug：Sealwort 18g, coptis 4g, peach kernel 8g, Angelica sinensis 4g, Chinese cassia tree 3g, flos caryophylli 4g, asarum 0.8g, galangal 3g, the root bark of tree peony 3g, Cortex Phellodendri 4g, dried rhizome of rehmannia 18g, evodia rutaecarpa 2g, Radix Salviae Miltiorrhizae 4g, root of Chinese trichosanthes 4.5g, adjutant：Dried peppermint leaf 2g, muscone 0.8g；It is described Active compound powder is pulverized and mixed to obtain by above-mentioned crude drug according to above-mentioned formula rate.

(1) crude drug is added to medicinal alcohol to soak 55 days, extracts effective liquid component, 3000ml wine with extract is made Smart solution；

In the present embodiment, the medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is 100 mesh, the temperature that boils is 135 DEG C, and described to boil the time be 40min.

Embodiment 7

The embodiment of the present invention 7 provides a kind of plaster for being used to treat diabetes and hypertension, and the plaster is by 3200ml Extract alcoholic solution, 12kg active compounds powder, 10kg vaseline, 32g borneols and 32g camphors are boiled and formed；Wherein, the extract Alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, and the crude drug includes：Monarch drug in a prescription：Ginseng 30g, radix astragali 60g, ministerial drug：Sealwort 20g, coptis 5g, peach kernel 10g, Angelica sinensis 5g, Chinese cassia tree 5g, flos caryophylli 5g, asarum 1g, galangal 5g, the root bark of tree peony 5g, Cortex Phellodendri 5g, dried rhizome of rehmannia 20g, evodia rutaecarpa 3g, Radix Salviae Miltiorrhizae 5g, root of Chinese trichosanthes 5g, adjutant：Dried peppermint leaf 2g, muscone 1g；The active compound Powder is pulverized and mixed to obtain by above-mentioned crude drug according to above-mentioned formula rate.

In the above-described embodiments, sealwort, the root bark of tree peony, the dried rhizome of rehmannia, the coptis, Cortex Phellodendri etc. are cold medicinal material, Chinese cassia tree, flos caryophylli, asarum, Galangal, evodia rutaecarpa etc. are hot medicinal material, this formula make use of cold medicinal material to restrict the hot of hot medicinal material, can avoid warming Too, it is cold too, make mild in medicine property and.

It should be noted that the plaster in above-described embodiment 1~7 can be used by dressing mode, one is made Kind is used for the dressing for treating diabetes and hypertension, and as depicted in figs. 1 and 2, which includes base material 1, adhered layer 2 and cream bed course 3, the adhered layer 2 is set on the surface of the substrate 1, and the cream bed course 3 is arranged on the surface of adhered layer 2, and plaster 4 can be set Put on cream bed course 3.Certainly, the outer layer of the dressing can also set separate paper.

When it is implemented, the base material could be provided as non-woven fabrics, the adhered layer could be provided as pressure sensitive adhesive, the cream Bed course could be provided as the water absorption pad containing cotton and viscose glue.

The application method of dressing is as follows：

1st, suggest sleeping preceding use.

2nd, navel is cleaned with water, alcohol cotton stick disinfection, takes this plaster one gram or so (broad bean size), be put into navel In, Sterilized application is fixed.

3rd, when small (limitation using 8) takes out ointment, clear water cleaning after getting up, then is sterilized with alcohol cotton stick, usually keeps tripe The dry and comfortable cleaning of navel eye.

4th, five days navels are adhered to, Yongquan acupoint is used alternatingly on one day foot.(drawing blood Gui Yuan)

Illnesses Diagnoses standard：

First, how diabetes to be made a definite diagnosis

3.9~6.1mmol/L of fasting blood-glucose (international standard) of normal person；Postprandial 2 hours, 3.9~7.8mmol/ of blood glucose L (international standard)；

Fasting blood-glucose >=7.0mmol/L of diabetes patient, or random time blood glucose >=11.1mmol/L, or oral glucose The 2 of tolerance test it is small when blood glucose >=11.1mmol/L, there is diabetic symptom once to make a definite diagnosis, it is asymptomatic to make a definite diagnosis twice.

2nd, how Definite Hypertension

Systolic pressure≤140mmHg (18.6kPa) of normal adult, diastolic pressure≤90mmHg (12kPa)；

Systolic pressure >=160mmHg (21.3kPa) of the adult of hypertension, diastolic pressure >=95mmHg (12.6kPa).

Some specific cases are set forth below to be explained：

Case 1：Mr. Tan, 52 years old, makes a definite diagnosis in Guangzhou Hospitals, and hypoglycemic Western medicine is not eaten when just finding, sexual disorders, Blood glucose peak reaches 13.4mmol/L, and the first time plaster on the 16th of August in 2014, is with the fasting blood-glucose measured before plaster 9.0mmol/L, 90~130mmHg of blood pressure, 131 jin of weight, after medication the latter moon, fasting blood-glucose 5.2mmol/L, blood pressure 80 ~120mmHg, 130 jin of weight, blood glucose and blood pressure recover normal, behind adhere to continuously using plaster 1 year, blood glucose is still can be controlled in 4.5~6.0mmol/L, sex dysfunction eliminate.

Case 2：Plain Miss, 47 years old, has found diabetes 1 year, eats the control of hypoglycemic Western medicine, become thin, dizzy, eyes obscure, The syndromes such as numbness in hands and feet, dry, frequent urination at night, poor sleeping quality, start on June 27th, 2016 to eat empty after hypoglycemic Western medicine controls Abdomen blood glucose is 5~6mmol/L, and after plaster, hypoglycemic Western medicine is eaten in stopping, and fasting blood-glucose still can be controlled in 4.5~6mmol/L, Postprandial 2 hour blood glucose returns to below 7.8mmol/L, syndrome substantially eliminates after using plaster 6 months.

Case 3：Miss Wang, 47 years old, 7 years medical histories, have visual impairment, have the pins and needles, dry, frequent micturition, hypertension, high blood The syndromes such as fat, poor sleeping quality, on December 4th, 2016 first time plaster, be with the fasting blood-glucose measured before plaster 10mmol/L, 90~150mmHg of blood pressure, 127 jin of weight, do not eat hypoglycemic Western medicine, with after plaster on July 16th, 2017 again Measurement, fasting blood-glucose 5.7mmol/L, 70~115mmHg of blood pressure, 114 jin of weight, postprandial 2 hour blood glucose is 7.9mmol/ L, to November 26 in 2017, fasting blood-glucose still can be controlled in 4.5~6mmol/L, and postprandial 2 hour glycemic controls are in 7.8mmol/ Below L, blood pressure is normal, and syndrome substantially eliminates.

Case 4：Miss Fan, 27 years old, there is the syndromes such as dizziness, muscle jump, poor sleeping quality, hypertension, paramenia, Eat hypoglycemic and western medicine of depressurization, fasting blood-glucose and blood pressure can be controlled in normal range (NR), the first time plaster on the 10th of September in 2017, and 10 The moon 1 starts to stop eating hypoglycemic and western medicine of depressurization, and so far, fasting blood-glucose still can be controlled in 4.5~6mmol/L, and controlling of blood pressure is 80 ~120mmHg, syndrome substantially eliminate.

Case 5：Miss Cheng, 33 years old, the first time plaster on the 17th of September in 2017, with the fasting blood-glucose measured before plaster For 4.5mmol/L, 130 jin of weight, belly is big, and after 3 months after plaster, to 123 jin, belly is obviously reduced weight loss.

According to statistics, effective 91 in more than the 100 example patients accepted for medical treatment, 91% is accounted for, no effect 9, accounts for 9%, acquirement can be preferable Clinical efficacy.

In conclusion the plaster of the present invention is externally applied drug, simplicity is prepared, medicine source is wide, it then follows the prescriptions principle of the traditional Chinese medical science, Verify by clinic application, it can reduce blood glucose and blood pressure, reach the effect for the treatment of diabetes and hypertension, improve because diabetes are drawn Rise have a headache, be thirsty, fatiguability, hand fiber crops, visual impairment, constipation, frequent micturition, the various syndromes such as sex dysfunction, raising machine The immune function of body, evident in efficacy, the medicine of a warm nature and cold medicine condition each other in side, mild in medicine property and, do not occur toxic side effect, have certain Fat-reducing effect, and can be pasted onto by dressing mode at the human bodies such as navel, Yongquan acupoint, easy to use, dosage is few, Paste that acupuncture point is accurate, and firm pasting, soiled clothes, not evident in efficacy, very by the favorable comment of patient, have medicine for oral administration and other externally applied drugs without The advantages of method is compared.

Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims

1. a kind of plaster for being used to treat diabetes and hypertension, it is characterised in that the plaster is extracted by 2800ml~3200ml Thing alcoholic solution, 8kg~12kg active compounds powder, 8kg~10kg vaseline, 28g~32g borneols and 28g~32g camphors boil and Into；

Wherein, the extract alcoholic solution is added to extract after medicinal alcohol immersion by crude drug and obtained, the crude drug bag Include：Monarch drug in a prescription：Ginseng 10g~30g, radix astragali 30g~60g, ministerial drug：Sealwort 10g~20g, coptis 1g~5g, peach kernel 5g~10g, when Return 1g~5g, Chinese cassia tree 1g~5g, flos caryophylli 1g~5g, asarum 0.5g~1g, galangal 1g~5g, root bark of tree peony 1g~5g, adjutant：It is thin Lotus leaf 1g~2g, muscone 0.5g~1g；

A kind of 2. plaster for being used to treat diabetes and hypertension according to claim 1, it is characterised in that：The active compound Ministerial drug in material further includes：Cortex Phellodendri 1g~5g, dried rhizome of rehmannia 10g~20g, evodia rutaecarpa 1g~3g, Radix Salviae Miltiorrhizae 1g~5g, root of Chinese trichosanthes 1g~ 5g。

A kind of 3. plaster for being used to treat diabetes and hypertension according to claim 1, it is characterised in that：It is described medical Alcohol is arranged to the medicinal alcohol of 95% concentration.

A kind of 4. plaster for being used to treat diabetes and hypertension according to claim 1, it is characterised in that：The active compound The mesh number of powder is the mesh of 80 mesh~120.

5. a kind of dressing for being used to treat diabetes and hypertension, including base material, adhered layer and cream bed course, the adhered layer are set On the surface of the substrate, the cream bed course is arranged on the surface of adhered layer, it is characterised in that the cream bed course is equipped with right It is required that the plaster for being used to treat diabetes and hypertension in 1~4 described in any one.

A kind of 6. dressing for being used to treat diabetes and hypertension according to claim 5, it is characterised in that：The base material Non-woven fabrics is arranged to, the adhered layer is arranged to pressure sensitive adhesive, and the cream bed course is arranged to the water absorption pad containing cotton and viscose glue.

7. a kind of preparation method for the plaster for being used to treat diabetes and hypertension, it is characterised in that comprise the following steps：

(1) crude drug is added to medicinal alcohol to soak 50~70 days, extracts effective liquid component, 2800ml~3200ml is made Extract alcoholic solution, wherein, the crude drug includes：Monarch drug in a prescription：Ginseng 10g~30g, radix astragali 30g~60g, ministerial drug：Sealwort 10g~20g, coptis 1g~5g, peach kernel 5g~10g, Angelica sinensis 1g~5g, Chinese cassia tree 1g~5g, flos caryophylli 1g~5g, asarum 0.5g~ 1g, galangal 1g~5g, root bark of tree peony 1g~5g, adjutant：1g~2g dried peppermint leaves, 0.5g~1g muscones；

(2) separately take more parts of crude drugs to be mixed into powder according to above-mentioned formula rate dries pulverizing, and therefrom weigh 8kg~12kg originals Medicinal powder；

(3) 8kg~12kg active compound powder is added among 8kg~10kg vaseline, adds 2800ml~3200ml extracts Alcoholic solution, 28g~32g borneols and 28g~32g camphors, are brewed into dark brown lotion.

8. a kind of preparation method of plaster for being used to treat diabetes and hypertension according to claim 7, its feature exist In：Ministerial drug in every part of crude drug of the step (1) and step (2) further includes：Cortex Phellodendri 1g~5g, dried rhizome of rehmannia 10g~20g, Wu Fruit of medicinal cornel 1g~3g, Radix Salviae Miltiorrhizae 1g~5g, root of Chinese trichosanthes 1g~5g.

9. a kind of preparation method of plaster for being used to treat diabetes and hypertension according to claim 7, its feature exist In：The medicinal alcohol is arranged to the medicinal alcohol of 95% concentration, and the mesh number of the active compound powder is the mesh of 80 mesh~120.

10. a kind of preparation method of plaster for being used to treat diabetes and hypertension according to claim 7, its feature exist In：The temperature that boils is 100 DEG C~150 DEG C, and described to boil the time be 30min~40min.