CN116350712B - Traditional Chinese medicine composition for treating polycystic ovarian syndrome and application thereof - Google Patents
Traditional Chinese medicine composition for treating polycystic ovarian syndrome and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating polycystic ovary syndrome and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-14 parts of cornu cervi degelatinatum, 13-17 parts of semen cuscutae, 4-8 parts of fried semen brassicae, 4-8 parts of roasted ephedra, 10-14 parts of platycodon grandiflorum, 7-11 parts of dandelion, 7-11 parts of honeysuckle, 10-14 parts of eupatorium, 10-14 parts of radix angelicae, 10-14 parts of lily, 10-14 parts of caulis perllae, 10-14 parts of leonurus, 10-14 parts of fried bighead atractylodes rhizome, 10-14 parts of radix cyathulae and 4-8 parts of raw liquorice. The traditional Chinese medicine composition provided by the invention can effectively treat polycystic ovary syndrome, and particularly has a good treatment effect on patients with infertility or bad pregnancy history.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating polycystic ovary syndrome and application thereof.
Background
Polycystic ovary syndrome (polycystic ovarian syndrome, PCOS) is a disorder characterized by hyperandrogenism, anovulation disorders, and polycystic ovary. The etiology of polycystic ovary syndrome is not completely clear, but mainly uses insulin resistance as a main related factor, and also comprises genetic factors and non-genetic factors, and the pathophysiology of polycystic ovary syndrome is mainly caused by metabolic disorder caused by insulin resistance and endocrine change caused by hypothalamic-pituitary-ovary axis regulation dysfunction. The disease has highly heterogeneous clinical syndrome, and different patients have different physiological and pathological manifestations. The clinical characteristics of the medicine are as follows: menstrual disorder, infertility, male sexual manifestations (hirsutism, acne), obesity, acanthosis nigricans, increased ovaries, endocrine changes (elevated androgen levels, altered estrogen, gonadotrophin changes, insulin resistance, hyperinsulinemia, elevated serum prolactin levels), long-term complications (tumors, cardiovascular diseases, diabetes).
Polycystic ovary syndrome is the most common endocrine and metabolic disorder in women, with a morbidity of 5-10%. PCOS is mainly pathophysiologically changed into a reproductive disorder and a metabolic abnormality, and the occurrence and development of the disease and clinical symptoms cover the life of women, and seriously affect the reproductive health and population quality of human beings. PCOS patients manifest themselves as intrauterine growth restriction (IUGR) in fetal phase leading to reduced birth weight; the phenomenon of weight catch-up occurs in childhood, which is a high-frequency population with overweight, obesity and menstrual disorder in adolescent girls; during the growth period, the main symptoms are amenorrhea and infertility, and the metabolic abnormality is mainly manifested by impaired glucose tolerance, abnormal lipid metabolism and the like; once pregnant, the incidence rate of gestational diabetes mellitus and gestational hypertension disease is increased by 5-10 times, and the IUGR of the intrauterine fetus is obviously increased; the probability of occurrence of diabetes, hypertension, cardiovascular and cerebrovascular diseases and other chronic diseases before and after menopause is increased by more than 4 times compared with normal women. PCOS has gradually been considered as an important component of metabolic syndrome due to its high incidence in women at different physiological stages. However, due to the unclear etiology, the treatment of PCOS by western medicine is stagnated in the stage of symptomatic treatment, and all the problems of patients cannot be completely solved, and adverse reactions of a large amount of long-time use of chemical medicaments and high heterogeneity of PCOS lead to complicated treatment for the disease, and most of the treatments are symptomatic treatment, rebound easily occurs after stopping the treatment, and the disease development is aggravated. The traditional Chinese medicine for preventing and treating PCOS has unique advantages, is now increasingly valued and accepted by the medical community, and has more reports on the traditional Chinese medicine for preventing and treating PCOS, but only treats diseases per se, or treats certain types or stages, has limited indications, is difficult to treat clinically, and needs to develop a traditional Chinese medicine composition with wide indications, so that the treatment effect on PCOS patients, especially PCOS patients with infertility or bad pregnancy history is improved.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating polycystic ovary syndrome and application thereof, so as to solve the problems of the prior art.
In order to achieve the above object, the present invention provides the following solutions:
the invention provides a traditional Chinese medicine composition for treating polycystic ovary syndrome, which comprises the following components in parts by weight: 10-14 parts of cornu cervi degelatinatum, 13-17 parts of semen cuscutae, 4-8 parts of fried semen brassicae, 4-8 parts of roasted ephedra, 10-14 parts of platycodon grandiflorum, 7-11 parts of dandelion, 7-11 parts of honeysuckle, 10-14 parts of eupatorium, 10-14 parts of radix angelicae, 10-14 parts of lily, 10-14 parts of caulis perllae, 10-14 parts of leonurus, 10-14 parts of fried bighead atractylodes rhizome, 10-14 parts of radix cyathulae and 4-8 parts of raw liquorice.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 12 parts of cornu cervi degelatinatum, 15 parts of semen cuscutae, 6 parts of stir-fried white mustard seed, 6 parts of roasted ephedra, 12 parts of platycodon grandiflorum, 9 parts of dandelion, 9 parts of honeysuckle, 12 parts of eupatorium, 12 parts of radix angelicae, 12 parts of lily, 12 parts of caulis perllae, 12 parts of motherwort, 12 parts of stir-fried bighead atractylodes rhizome, 12 parts of radix cyathulae and 6 parts of raw liquorice.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating polycystic ovary syndrome.
The invention also provides a medicine for treating polycystic ovary syndrome, and the raw materials comprise the traditional Chinese medicine composition.
Further, the medicament also comprises pharmaceutically acceptable auxiliary materials.
Further, the dosage form of the medicament comprises powder, pill, granule, paste or tablet.
The invention also provides a preparation method of the medicine, which comprises the steps of extracting the active ingredients in the traditional Chinese medicine composition by using a solvent and preparing the medicine.
Further, the solvent includes water.
The invention discloses the following technical effects:
in the traditional Chinese medicine composition of the invention: cornu Cervi Degelatinatum is salty, astringent, warm, and enters liver and kidney meridians to warm kidney and strengthen yang, and is a monarch drug. Semen cuscutae is sweet and warm, enters liver, kidney and spleen channels, nourishes liver and kidney, arrest semen, prevent abortion and improve eyesight; the fried white atractylodes rhizome is sweet and warm, has the functions of invigorating spleen and stomach meridian, strengthening spleen and replenishing qi, drying dampness and promoting diuresis, and preventing miscarriage; the stir-fried white mustard seed is pungent and warm, enters lung and stomach meridians, promotes qi circulation and eliminates phlegm, warms middle-jiao and dispels cold, and relieves pain, and the three medicines are ministerial medicines. Dandelion has the effects of clearing heat and detoxicating, eliminating carbuncles and resolving masses, and promoting diuresis and treating stranguria; honeysuckle flower, flos Lonicerae, sweet and cold, enters the lung, heart and stomach meridians, and clears away heat and toxic materials; the roasted ephedra can ventilate the lung and promote diuresis; radix angelicae dehumidifies and promotes tissue regeneration, and activates blood circulation to relieve pain; herba Leonuri has effects of promoting blood circulation, removing blood stasis, detumescence and resolving hard mass; radix Platycodi has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus; herba Eupatorii fragrance for eliminating dampness; lily is sweet in taste and cold in nature, and can return to heart and lung channels, nourish yin and clear heart, calm heart and tranquilize mind; caulis Perillae is pungent and sweet, slightly warm, and has effects of invigorating lung, spleen and stomach channels, relieving chest stuffiness, benefiting diaphragm, regulating qi and preventing miscarriage; radix Cyathulae is bitter, sweet and sour, and has effects of calming liver, invigorating kidney, promoting blood circulation, dredging channels, nourishing liver and kidney, strengthening tendons and bones, guiding drugs downwards, and the ten drugs are adjuvant drugs. The raw licorice is sweet and flat, enters heart, lung, spleen and stomach meridians, supplements qi and supplements middle-jiao, clears away heat and toxic materials, eliminates phlegm and relieves cough, relieves spasm and pain, and harmonizes drug properties, thus being a guiding drug. The medicines are combined together to play the roles of nourishing liver and kidney, strengthening spleen and nourishing heart, resolving phlegm and removing dampness, promoting blood circulation and regulating menstruation.
The mouse experiment proves that the traditional Chinese medicine composition can effectively treat polycystic ovary syndrome, and particularly has a good treatment effect on patients with infertility or bad gestation history.
Detailed Description
Various exemplary embodiments of the invention will now be described in detail, which should not be considered as limiting the invention, but rather as more detailed descriptions of certain aspects, features and embodiments of the invention.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. In addition, for numerical ranges in this disclosure, it is understood that each intermediate value between the upper and lower limits of the ranges is also specifically disclosed. Every smaller range between any stated value or stated range, and any other stated value or intermediate value within the stated range, is also encompassed within the invention. The upper and lower limits of these smaller ranges may independently be included or excluded in the range.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference for the purpose of disclosing and describing the methods and/or materials associated with the documents. In case of conflict with any incorporated document, the present specification will control.
It will be apparent to those skilled in the art that various modifications and variations can be made in the specific embodiments of the invention described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from consideration of the specification of the present invention. The specification and examples of the present invention are exemplary only.
As used herein, the terms "comprising," "including," "having," "containing," and the like are intended to be inclusive and mean an inclusion, but not limited to.
Example 1
Raw materials: ( First ) 10g of cornu cervi degelatinatum, 17g of semen cuscutae, 4g of fried semen brassicae, 8g of roasted ephedra, 10g of platycodon grandiflorum, 7g of dandelion, 11g of honeysuckle, 14g of eupatorium fortunei, 10g of radix angelicae, 10g of lily, 10g of caulis perllae, 14g of leonurus, 14g of fried bighead atractylodes rhizome, 14g of radix cyathulae and 8g of raw liquorice.
The preparation method comprises the following steps: soaking the above materials in water, decocting cornu Cervi Degelatinatum for 30min, adding the rest materials, decocting for 2 times and 25 min each time, mixing decoctions, filtering, and drying to obtain Chinese medicinal extract.
Example 2
Raw materials: cornu Cervi Degelatinatum ( First ) g, semen Cuscutae 15g, semen Sinapis Albae preparata 6g, herba Ephedrae preparata 6g, radix Platycodi 12g, herba Taraxaci 9g, flos Lonicerae 9g, herba Eupatorii 12g, radix Angelicae Dahuricae 12g, bulbus Lilii 12g, caulis Perillae 12g, herba Leonuri 12g, atractylodis rhizoma 12g, radix Cyathulae 12g and Glycyrrhrizae radix 6g.
The preparation method comprises the following steps: the preparation method comprises the following steps: soaking the above materials in water, decocting cornu Cervi Degelatinatum for 30min, adding the rest materials, decocting for 2 times and 25 min each time, mixing decoctions, filtering, and drying to obtain Chinese medicinal extract.
Example 3
Raw materials: cornu Cervi Degelatinatum ( First ) g, semen Cuscutae 13g, semen Sinapis Albae 8g, herba Ephedrae preparata 4g, radix Platycodi 14g, herba Taraxaci 11g, flos Lonicerae 7g, herba Eupatorii 10g, radix Angelicae Dahuricae 14g, bulbus Lilii 14g, caulis Perillae 14g, herba Leonuri 10g, atractylodis rhizoma 10g, radix Cyathulae 10g and Glycyrrhrizae radix 4g.
The preparation method comprises the following steps: the preparation method comprises the following steps: soaking the above materials in water, decocting cornu Cervi Degelatinatum for 30min, adding the rest materials, decocting for 2 times and 25 min each time, mixing decoctions, filtering, and drying to obtain Chinese medicinal extract.
Comparative example 1
The only difference from example 2 is that the stir-fried white mustard seeds are replaced with raw white mustard seeds.
Comparative example 2
The only difference from example 2 is that the roasted ephedra is replaced with cassia twig.
Comparative example 3
The only difference from example 2 is that the herba Eupatorii is replaced with herba Pogostemonis.
Effect verification
1. Method of
C57 mice are purchased from Beijing shellfish organisms, the temperature is 20-24 ℃, the constant humidity is 50-60%, the light is irradiated for 12 hours (8:00-20:00), sound insulation is realized, food and water are freely ingested, and experiments are carried out after one week of adaptation to the environment.
Adult C57 female mice and male mice were caged at 4 PM on the first 1 day, the caged ratio was 2:1, the next morning, and the male mice with the bolts were marked and divided into two groups, which was designated as day 1. Mice in the control group were injected subcutaneously with 200 μl sesame oil daily on the back of the mice 16, 17, 18 days after thrombus formation, mice in the model group were injected subcutaneously with 200 μl of DHT (dihydrotestosterone) containing sesame oil daily on the back of the mice (DHT amount was 250 μg) and the injection was continued for 3 days. After 2 months, ovaries of offspring females were collected, fixed with 4% paraformaldehyde for 48 hours, rinsed with running water for 6 hours, embedded, HE stained and the ovaries were observed under a microscope. The results showed that the model group offspring adult female ovaries presented multiple sacs compared to the control group, indicating that PCOS mouse model construction was successful.
140 PCOS mice were taken and randomly divided into 7 groups of 20 mice each. Wherein 6 groups were respectively subjected to stomach irrigation with the extracts of the traditional Chinese medicines prepared in examples 1-3 and comparative examples 1-3 (diluted in water for stomach irrigation), and the stomach irrigation amount was 10 mg/kg/d; the other 1 group was used as a model control group, and the same volume of water was used in place of the herbal extract. Then, 20 normal C57 female mice were taken as normal control group.
Each experimental group was continuously dosed for 4 weeks, after the last dose, normal feed and drinking water were given, 4 male mice in physiological maturity stage were added to each group, and the number of pregnant females and the parity of each group were counted after 2 months.
2. Results
TABLE 1
Note that: * Significant P <0.05 from normal control group; # Significant P <0.05 from the model control group was indicated.
The results show that the number of pregnant female mice and parity in the model control group is obviously lower than that in the normal control group; after the traditional Chinese medicine extract is taken, although the traditional Chinese medicine extract still has certain difference from a normal control group, the number of pregnant female mice and parity animals is obviously improved. Therefore, the traditional Chinese medicine composition can treat polycystic ovary syndrome, and has good treatment effect on patients with infertility or bad pregnancy history.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (8)
1. The traditional Chinese medicine composition for treating polycystic ovary syndrome is characterized by being prepared from the following components in parts by weight: 10-14 parts of cornu cervi degelatinatum, 13-17 parts of semen cuscutae, 4-8 parts of fried semen brassicae, 4-8 parts of roasted ephedra, 10-14 parts of platycodon grandiflorum, 7-11 parts of dandelion, 7-11 parts of honeysuckle, 10-14 parts of eupatorium, 10-14 parts of radix angelicae, 10-14 parts of lily, 10-14 parts of caulis perllae, 10-14 parts of leonurus, 10-14 parts of fried bighead atractylodes rhizome, 10-14 parts of radix cyathulae and 4-8 parts of raw liquorice.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following components in parts by weight: 12 parts of cornu cervi degelatinatum, 15 parts of semen cuscutae, 6 parts of stir-fried white mustard seed, 6 parts of roasted ephedra, 12 parts of platycodon grandiflorum, 9 parts of dandelion, 9 parts of honeysuckle, 12 parts of eupatorium, 12 parts of radix angelicae, 12 parts of lily, 12 parts of caulis perllae, 12 parts of motherwort, 12 parts of stir-fried bighead atractylodes rhizome, 12 parts of radix cyathulae and 6 parts of raw liquorice.
3. Use of a traditional Chinese medicine composition according to claim 1 or 2 for preparing a medicament for treating polycystic ovary syndrome.
4. A medicament for treating polycystic ovary syndrome, which is characterized in that raw materials comprise the traditional Chinese medicine composition as claimed in claim 1 or 2.
5. The medicament of claim 4, further comprising a pharmaceutically acceptable excipient.
6. The medicament according to claim 5, wherein the dosage form of the medicament comprises a powder, a pill, a granule, a paste or a tablet.
7. The method for preparing a medicament according to claim 4, which comprises the step of extracting the active ingredient of the Chinese medicinal composition according to claim 1 or 2 with a solvent and preparing the medicament.
8. The method of claim 7, wherein the solvent comprises water.
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