CN1973864B - Medicine composition for treating hematuria and nephropyelitis and its preparation - Google Patents
Medicine composition for treating hematuria and nephropyelitis and its preparation Download PDFInfo
- Publication number
- CN1973864B CN1973864B CN2006101123057A CN200610112305A CN1973864B CN 1973864 B CN1973864 B CN 1973864B CN 2006101123057 A CN2006101123057 A CN 2006101123057A CN 200610112305 A CN200610112305 A CN 200610112305A CN 1973864 B CN1973864 B CN 1973864B
- Authority
- CN
- China
- Prior art keywords
- parts
- paste
- pyelonephritis
- hematuria
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The medicine composition for treating hematuria and nephropyelitis is prepared with astragalus root 3- 100 weight portions, date coating 3-100 weight portions and ass-hide gelatin 5-150 weight portions. The preparation process includes the steps of decoction, filtering, concentrating the filtrate to obtain paste of density 1.00-1.15, dissolving the paste in alcohol, filtering, concentrating the filtrate to obtain dense paste of density 1.20-1.50 while recovering alcohol, and drying to obtain the medicine composition. The medicine composition is used in treating hematuria and nephropyelitis, and has high safety, low cost, high effective component content and high stability.
Description
Technical field
The present invention relates to the Chinese herbal medicine is the nourishing YIN and clearing away heat that forms of feedstock production, pharmaceutical composition of QI invigorating dampness removing medicament and preparation method thereof, refers to a kind of pharmaceutical composition for the treatment of hematuria and pyelonephritis and preparation method thereof particularly, belongs to the field of Chinese medicines.
Background technology
Hematuria and pyelonephritis are a kind of gross hematuria (eliminating urinary system calculus) and urine urgency-frequency, the heeltap waits the clinical symptoms that shows not to the utmost, is common diseases of urinary system.Its many clinically by acute transfer to chronic, normal protracted course of disease, the treatment difficulty is very big, causes great misery to the patient, does not still have ideal medicine so far, makes the clinicist quite feel thorny.The patient who particularly has is cherish life not, and eating and drinking too much at one meal injures taste and kidney yin, or excess of sexual intercourse undermines kidney yin and fall ill, thereby presses for a kind of safe and reliable treatment new drug.This disease of state's internal therapy Chinese medicine commonly used has SANJIN PIAN at present, and Western medicine commonly used is the medicine of antibiotics one class, as penicillin, a Bao An Bian etc., in this type of medicine, Chinese medicine has only heat clearing away, detoxifcation, diuresis, and Western medicine can only antiinflammatory---take stopgap measures, after several days, also recurrence.
Summary of the invention
The objective of the invention is to overcome the weak point of above-mentioned drug effect aspect, provide that a kind of safety is good, cost is low, active constituent content is higher, the better a kind of pharmaceutical composition for the treatment of hematuria and pyelonephritis of stability.
Another object of the present invention is to provide a kind of preparation of drug combination method for the treatment of hematuria and pyelonephritis.
According to China's theory of Chinese medical science and practice, think with reference to modern pharmacological research: the key of hematuria and pyelonephritis morbidity is suffer from a deficiency of the kidney (deficiency of the kidney yin), and the deficiency of YIN is given birth to interior-heat, asthenic fire is burnt network and caused hematuria, frequent micturition.Except that the treatment blood deficiency, also wanting the QI invigorating dampness removing during treatment, is the reason according to the mutual root of QI and blood, on the basis of nourishing YIN and clearing away heat, add the medicine of QI invigorating dampness removing, thereby reach reinforcing both QI and YIN, treating YANG within YIN, cloudy positive helping, effect is infinite, and does not have any toxicity, side effect.Nourishing YIN and clearing away heat, QI invigorating dampness removing Chinese medicine preparation by prepared of the present invention forms not only can play heat clearing away, diuresis, relief of symptoms, and reach radical cure by the medicine of enriching yin boost qi, do not recur.
The present invention is according to above-mentioned theory, from China's medicine treasure-house, filter out nourishing YIN and clearing away heat, the natural Chinese medicine of QI invigorating dampness removing, according to applicant's clinical experience composing prescription preparation for many years, extract wherein elite, make its performance greatest benefit, be not only simple nourishing YIN and clearing away heat treatment, also add Therapeutic Method, make it reach more peculiar effect, and can thoroughly effect a radical cure, not recur with the QI invigorating dampness removing.
A kind of pharmaceutical composition for the treatment of hematuria and pyelonephritis of the present invention, the consumption of drug component is groped to sum up to draw through the inventor in a large number, and each amounts of components all has curative effect preferably in following weight parts:
Major ingredient is: Radix Astragali 3-100 part Fructus Corni 3-100 part Colla Corii Asini 5-150 part
Be preferably: Radix Astragali 5-30 part Fructus Corni 5-30 part Colla Corii Asini 8-30 part
Elitely be: 20 parts in 15 parts of Colla Corii Asini of 15 parts of Fructus Cornis of the Radix Astragali
The above-mentioned treatment hematuria and the pharmaceutical composition of pyelonephritis can also comprise:
Rhizoma Dioscoreae 2-100 part Rhizoma Atractylodis Macrocephalae 2-100 part Cortex Moutan 3-100 part
Cortex Phellodendri 2-100 part Radix Rehmanniae 3-100 part
Be preferably
Rhizoma Dioscoreae 5-20 part Rhizoma Atractylodis Macrocephalae 5-30 part Cortex Moutan 5-30 part
Cortex Phellodendri 5-20 part Radix Rehmanniae 5-30 part
Elitely be
8 parts of 10 parts of Cortex Moutans of 10 parts of Rhizoma Atractylodis Macrocephalae of Rhizoma Dioscoreae
The 10 parts of above-mentioned treatment hematurias of 8 parts of Radix Rehmanniae of Cortex Phellodendri and the pharmaceutical composition of pyelonephritis can also comprise:
Rhizoma Alismatis 3-100 part Pericarpium Citri Reticulatae 3-100 part
Be preferably
Rhizoma Alismatis 5-20 part Pericarpium Citri Reticulatae 5-20 part
Elitely be
8 parts of 8 parts of Pericarpium Citri Reticulataes of Rhizoma Alismatis
The preparation of drug combination method of a kind of above-mentioned treatment hematuria and pyelonephritis, it is made up of the following step:
By above-mentioned weight portion proportioning flavor Chinese medicines such as the Radix Astragali, Fructus Corni, Colla Corii Asini or the Radix Astragali, Fructus Corni, Colla Corii Asini, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae or the Radix Astragali, Fructus Corni, Colla Corii Asini, Rhizoma Dioscoreae, Rhizoma Atractylodis Macrocephalae, Cortex Moutan, Cortex Phellodendri, the Radix Rehmanniae, Rhizoma Alismatis, Pericarpium Citri Reticulatae are decocted with water 2-5 time, add as raw material weight 3-9 decocting doubly boiled 0.5-3 hour at every turn, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00-1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30-80%, stirs evenly, and leaves standstill 6-24 hour, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20-1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
Pharmaceutical composition of the present invention can be aided with the various adjuvants on the pharmaceutics, is prepared into various common formulations, as oral liquid, syrup, medicated wine and tincture, injection, lyophilized injectable powder, capsule, tablet, granule etc.; When being prepared as solid preparations such as capsule, tablet, granule, used adjuvant can be: mannitol, starch, beta-schardinger dextrin-, low-substituted hydroxypropyl cellulose, micropowder silica gel, carboxymethyl starch sodium, crospolyvinylpyrrolidone, magnesium stearate, cross-linking sodium carboxymethyl cellulose, carboxymethylcellulose calcium, xylitol, microcrystalline Cellulose, honey peach essence etc.
Pharmaceutical composition of the present invention can also add various conventional adjuvant required when preparing different dosage form, prepare any peroral dosage form commonly used as disintegrating agent, lubricant, binding agent etc. with the method for Chinese medicinal of routine, as the dispersible tablet in pill, powder, capsule or the tablet, oral cavity disintegration tablet, effervescent tablet, general thin coated tablet etc.
Pharmaceutical composition of the present invention has QI invigorating, consolidating superficial resistance, dampness removing, sensible effect, is a kind of ideal (present stage) pharmaceutical composition for the treatment of hematuria and pyelonephritis.
The dose of medicine of the present invention can be according to variations such as route of administration, pill taker's age, body weight, and its daily dose can be the 0.01-10mg/kg body weight, and preferred 2-6mg/kg body weight can be taken by one or many.
The invention has the advantages that selecting ten flavor crude drugs for use is that raw material carries out assembly, particularly wherein the Radix Astragali, Fructus Corni, Colla Corii Asini three flavor principal agents merge use, have the unique effects of nourishing YIN and clearing away heat, QI invigorating dampness removing.Can control the interior-heat caused by deficiency of YIN that the patient causes because of asthenia of both the spleen and kidney and hinder the hematuria of network and the frequent micturition of deficiency of vital energy domination of damp pathogen, the heeltap waits disease not to the utmost.
Through clinical observation, confirm that its curative effect height, adaptability are strong, the effective percentage of treatment hematuria and pyelonephritis reaches more than 90%, significantly is better than existing Western medicine and similar Chinese medicine compound preparation.And selected natural material is no rare animal medical material, no valuable medicinal, avirulence or limiting the use of property medical material, the outer medical material of no grade III Standard, and each component meets the pharmaceutical control law regulation.It organically combines, and co-action for treating hematuria and pyelonephritis almost do not have any toxicity, side effect, simultaneously prepared and Chinese medicine need not to decoct, it is all convenient to take, carry.Because of cost of drugs is low, reduced patient's medical expense, be easy to clinical application, have the wide development prospect.
The specific embodiment
The following examples can make the professional and technical personnel understand the present invention comprehensively, better, but cannot limit the present invention by any way:
The preparation of drug combination of embodiment 1 Drug therapy hematuria of the present invention and pyelonephritis
With 3 parts of the Radixs Astragali, 100 parts of Fructus Cornis, 5 parts in Colla Corii Asini, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 2 Drug therapy hematurias of the present invention and pyelonephritis
With 100 parts of the Radixs Astragali, 3 parts of Fructus Cornis, 150 parts in Colla Corii Asini, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 3 Drug therapy hematurias of the present invention and pyelonephritis
With 5 parts of the Radixs Astragali, 30 parts of Fructus Cornis, 8 parts in Colla Corii Asini, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 4 Drug therapy hematurias of the present invention and pyelonephritis
With 30 parts of the Radixs Astragali, 5 parts of Fructus Cornis, 30 parts in Colla Corii Asini, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 5 Drug therapy hematurias of the present invention and pyelonephritis
With 15 parts of the Radixs Astragali, 15 parts of Fructus Cornis, 20 parts in Colla Corii Asini, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 1.5 hours, filters, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 6 Drug therapy hematurias of the present invention and pyelonephritis
With 3 parts of the Radixs Astragali, 100 parts of Fructus Cornis, 5 parts in Colla Corii Asini, 2 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Cortex Moutans, 100 parts of Cortex Phellodendris, 3 parts in the Radix Rehmanniae, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filtered, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 7 Drug therapy hematurias of the present invention and pyelonephritis
With 100 parts of the Radixs Astragali, 3 parts of Fructus Cornis, 150 parts in Colla Corii Asini, 100 parts of Rhizoma Dioscoreaes, 2 parts of Rhizoma Atractylodis Macrocephalae, 100 parts of Cortex Moutans, 2 parts of Cortex Phellodendris, 100 parts in the Radix Rehmanniae, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 8 Drug therapy hematurias of the present invention and pyelonephritis
With 5 parts of the Radixs Astragali, 30 parts of Fructus Cornis, 8 parts in Colla Corii Asini, 5 parts of Rhizoma Dioscoreaes, 30 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Cortex Moutans, 20 parts of Cortex Phellodendris, 5 parts in the Radix Rehmanniae, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filtered, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 9 Drug therapy hematurias of the present invention and pyelonephritis
With 30 parts of the Radixs Astragali, 5 parts of Fructus Cornis, 30 parts in Colla Corii Asini, 20 parts of Rhizoma Dioscoreaes, 5 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of Cortex Moutans, 5 parts of Cortex Phellodendris, 30 parts in the Radix Rehmanniae, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filtered, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 10 Drug therapy hematurias of the present invention and pyelonephritis
With 15 parts of the Radixs Astragali, 15 parts of Fructus Cornis, 20 parts in Colla Corii Asini, 10 parts of Rhizoma Dioscoreaes, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Cortex Moutans, 8 parts of Cortex Phellodendris, 10 parts in the Radix Rehmanniae, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 1.5 hours, filtered, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 11 Drug therapy hematurias of the present invention and pyelonephritis
With 3 parts of the Radixs Astragali, 100 parts of Fructus Cornis, 5 parts in Colla Corii Asini, 2 parts of Rhizoma Dioscoreaes, 100 parts of Rhizoma Atractylodis Macrocephalae, 3 parts of Cortex Moutans, 100 parts of Cortex Phellodendris, 3 parts in the Radix Rehmanniae, 3 parts of Rhizoma Alismatis, 100 parts of Pericarpium Citri Reticulataes, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 12 Drug therapy hematurias of the present invention and pyelonephritis
With 100 parts of the Radixs Astragali, 3 parts of Fructus Cornis, 150 parts in Colla Corii Asini, 100 parts of Rhizoma Dioscoreaes, 2 parts of Rhizoma Atractylodis Macrocephalae, 100 parts of Cortex Moutans, 2 parts of Cortex Phellodendris, 100 parts in the Radix Rehmanniae, 100 parts of Rhizoma Alismatis, 3 parts of Pericarpium Citri Reticulataes, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 13 Drug therapy hematurias of the present invention and pyelonephritis
With 5 parts of the Radixs Astragali, 30 parts of Fructus Cornis, 8 parts in Colla Corii Asini, 5 parts of Rhizoma Dioscoreaes, 30 parts of Rhizoma Atractylodis Macrocephalae, 5 parts of Cortex Moutans, 20 parts of Cortex Phellodendris, 5 parts in the Radix Rehmanniae, 5 parts of Rhizoma Alismatis, 20 parts of Pericarpium Citri Reticulataes, decoct with water 2 times, the decocting that at every turn adds as 9 times of raw material weights boiled 0.5 hour, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.00 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 30%, stirs evenly, and leaves standstill 24 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.20 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 14 Drug therapy hematurias of the present invention and pyelonephritis
With 30 parts of the Radixs Astragali, 5 parts of Fructus Cornis, 30 parts in Colla Corii Asini, 20 parts of Rhizoma Dioscoreaes, 5 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of Cortex Moutans, 5 parts of Cortex Phellodendris, 30 parts in the Radix Rehmanniae, 20 parts of Rhizoma Alismatis, 5 parts of Pericarpium Citri Reticulataes, decoct with water 5 times, the decocting that at every turn adds as 3 times of raw material weights boiled 3 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.15 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 80%, stirs evenly, and leaves standstill 6 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.50 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
The preparation of drug combination of embodiment 15 Drug therapy hematurias of the present invention and pyelonephritis
With 15 parts of the Radixs Astragali, 15 parts of Fructus Cornis, 20 parts in Colla Corii Asini, 10 parts of Rhizoma Dioscoreaes, 10 parts of Rhizoma Atractylodis Macrocephalae, 8 parts of Cortex Moutans, 8 parts of Cortex Phellodendris, 10 parts in the Radix Rehmanniae, 8 parts of Rhizoma Alismatis, 8 parts of Pericarpium Citri Reticulataes, decoct with water 3 times, the decocting that at every turn adds as 6 times of raw material weights boiled 1.5 hours, filter, merging filtrate, being concentrated into relative density then is the clear paste of 1.10 (90 ℃).
The back adds ethanol in the above-mentioned clear paste that makes, make ethanol content reach 55%, stirs evenly, and leaves standstill 15 hours, filter, and filtrate recycling ethanol, and be concentrated into the thick paste that relative density is 1.30 (90 ℃).Again paste is carried out dried, promptly get the pharmaceutical composition that the present invention treats hematuria and pyelonephritis.
Embodiment 16 the present invention treat the preparation of hematuria and the agent of pyelonephritis medicament composition capsule
Get the pharmaceutical composition that any the present invention that embodiment 1-15 makes treats hematuria and pyelonephritis, according to 1: 1 ratio and medical auxiliary materials and mixing commonly used, incapsulate, the 500mg/ capsule promptly makes medicament composition capsule of the present invention.Instructions about how to take medicine, every day 6 times, each 6, the 2-3 month of taking medicine continuously is a course of treatment.
Embodiment 17 the present invention treat the preparation of hematuria and pyelonephritis pharmaceutical composition tablet
Get the pharmaceutical composition that any the present invention that embodiment 1-15 makes treats hematuria and pyelonephritis, according to 1: 1 ratio and medical auxiliary materials and mixing commonly used, be pressed into tablet, the 500mg/ sheet promptly makes pharmaceutical composition tablet of the present invention.Instructions about how to take medicine, every day 6 times, each 6, the 2-3 month of taking medicine continuously is a course of treatment.
Embodiment 18 the present invention treat the preparation of hematuria and the agent of pyelonephritis medicament composition granule
Get the pharmaceutical composition that any the present invention that embodiment 1-15 makes treats hematuria and pyelonephritis, add right amount of auxiliary materials, spray drying with beta-schardinger dextrin-, micropowder silica gel mixing, is granulated, and the 2g/ bag promptly makes medicament composition granule agent of the present invention.Instructions about how to take medicine, warm boiled water, a 2-3 bag, 3-4 time on the one or follow the doctor's advice, the 2-3 month of taking medicine continuously is a course of treatment.
Below further set forth the beneficial effect of medicine of the present invention by testing example, comprise that the pharmacodynamics test of medicine of the present invention and clinical observation on the therapeutic effect test.
Test example 1 is observed the toxicity test of medicine of the present invention to mice
Test material:
(1) pharmaceutical composition of the present invention: be prepared into thick paste by the embodiment of the invention 1, Xiantao City institute of traditional Chinese medicine in Hubei Province's provides lot number: 060536.
(2) animal: 80 of ICR white mice, body weight is 60-80g, and Professional School provides by Hubei Province's Xiantao City.
(3) condition: room temperature 20-25 ℃, humidity 50-60%.
Test method:
30 days feeding trials: select 80 of ICR white mice for use, male and female half and half, all 60-80g is divided into four groups at random, and 20 every group, male and female half and half, single cage is raised.Tried thing and established three test doses, be respectively the 1.2g/kg body weight, 2.5g/kg body weight, 5.0g/kg (be equivalent to recommended amounts 100 times), the thing that tried of each dosage all is incorporated into each treated animal of nursing in the feedstuff by 10% of body weight, and incorporation is respectively 1.2%, 2.5%, 5.0%.If a false matched group is only given normal feedstuff.Equal ad lib of each treated animal and drinking-water during the nursing, weigh weekly and write down feed consumption once, experiment is adopted tail blood and carry out hematology and biochemical analysis latter stage, observation index has body weight, food utilization, adopt blood counting instrument to carry out blood test, adopt corresponding reagent box and automatic biochemistry analyzer to carry out biochemical test behind the separation of serum and learn inspection, test and put to death white mice latter stage, liver,spleen,kidney is got in dissection, testis/ovary is weighed, calculate organ coefficient, then liver,spleen,kidney, intestinal are carried out histopathologic examination's (paraffin section).
Result of the test:
1, fed through 30 days, white mice all survives, and each treated animal physically well develops, the no abnormality seen sign.
2, to the influence of white mice body weight: each organizes body weight there are no significant difference.
3, to the influence of white mice food utilization: each organizes the food utilization of white mice and matched group relatively there are no significant difference.
4, hematological examination: when experiment finished, each treated animal erythrocyte, hemoglobin, leukocyte were all in normal range.
5, biochemical investigation in latter stage result: when experiment finished, each treated animal glutamate pyruvate transaminase (performance rate method), blood glucose (hexokinase method), blood urea nitrogen (ultraviolet method), T-CHOL (enzyme process), triglyceride (enzyme process), creatinine (picric acid two-point method), total protein (biuret method), albumin indexs such as (bromine cresol chlorine methods) all fluctuateed in normal range.
6, histopathologic examination: each internal organs no abnormality seen of white mice is respectively organized in gross anatomy.The lobules of liver structure that histopathologic examination respectively organizes white mice is normal, and hepatocyte does not have degeneration, necrosis, no cell infiltration and proliferation of fibrous tissue between lobule; Glomerule, renal tubules structure are normal, and renal cells does not have degeneration, necrosis, no abnormal material in the tube chamber, and a matter does not have cell infiltration, hemorrhage and proliferation of fibrous tissue; Coat of the stomach and duodenal wall clear in structure are complete, no hemorrhage, cell infiltration, and gastric epithelial cell and intestinal epithelial cell do not have degeneration, necrosis, damaged.Do not see and produced specific pathological change trying treated animal liver, kidney, stomach and intestinal.
Conclusion (of pressure testing): nontoxic, the side effect of pharmaceutical composition of the present invention.
The clinical observation contrast test of test example 2 Drug therapy hematurias of the present invention and pyelonephritis
Test material:
Pharmaceutical composition of the present invention is prepared into granule by the embodiment of the invention 2, and Xiantao City institute of traditional Chinese medicine in Hubei Province's provides lot number: 060537; SANJIN PIAN, Guilin three gold medal pharmaceutcal corporation, Ltds provide lot number: 0511022; Bao An Bian capsule, pharmacy head factory in the Guangxi White Yunshan Mountain provides lot number: 5660038.
Test method: select example surplus the case 100 from outpatient service, random packet is observed.Wherein:
Test group 60 example is treated with Chinese medicine granules of the present invention, male 25 examples, women 35 examples, 12 ~ 72 years old age, 42 years old mean age, 10 examples of chronic heavy type wherein, chronic medium-sized 50 examples, the course of disease 3 ~ 120 months, average 61.5 months, first visit 26 examples, further consultation 34 examples; This group patient all takes Chinese medicine granules of the present invention, the each clothes of dosage adult 2-3 bag, 3-4 time on the 1st, warm boiled water.
1 group of 20 example of matched group is with SANJIN PIAN treatment, male 8 examples, women 12 examples, 12 ~ 68 years old age, 40 years old mean age; Matched group is all taken the SANJIN PIAN treatment for 1 group, is grown up 1 3-4 sheet 3 times on the 1st.
2 group of 20 example of matched group, with a Bao An Bian capsule for treating, male 9 examples, women 11 examples, 10 ~ 66 years old age, 38 years old mean age; Contrast 2 groups of patients and all take a Bao An Bian capsule, be grown up 3 times on the 1st, 1 2-4 sheet (250mg-500mg), the child is cut down according to the circumstance.
Three groups of patient treatments were a course of treatment with three months all, and test is two courses of treatment, sees Table 1.
Table 1 take behind Chinese medicine of the present invention and SANJIN PIAN, the Bao An Bian clinical efficacy relatively
Explanation
1. hematuria and pyelonephritis routine urianlysis before the treatment: the red C++++ of gross hematuria, urine protein ±, epithelium C a little, white C++ or a little;
2. cure the back routine urinalysis: red C-, urine protein-, epithelium C a little, white C-;
3. alleviate: the red C++ of routine urinalysis, urine protein ±, epithelium C a little, white C+;
4. obviously progressive: routine urinalysis, red C++, urine protein+, epithelium C a little, white C+;
5. invalid: routine urinalysis is the same with firm disease time, no change.
Conclusion (of pressure testing): from above-mentioned test data as can be known, test group is cured substantially, alleviation and total effective rate all obviously are better than contrasting one group and contrast two groups.
In above-mentioned test example, no matter adopting the inventive method still is other method, needs only its composition, content within the scope of the present invention, all has essentially identical therapeutic effect.
Claims (2)
1. a pharmaceutical composition for the treatment of hematuria and pyelonephritis is characterized in that it is prepared from by following bulk drugs: 100 parts of the Radixs Astragali, 3 parts of Fructus Cornis, 150 parts in Colla Corii Asini.
2. the described preparation of drug combination method of claim 1 is characterized in that comprising the steps:
A) by weight ratio described Chinese medicine is decocted with water 2-5 time, add as crude drug weight 3-9 decocting doubly at every turn and boiled 0.5-3 hour, filter, merge and filter, be condensed into clear paste then, its relative density is 1.00-1.15 in the time of 90 ℃;
B) in the above-mentioned clear paste that makes, add ethanol, make ethanol content reach 30%-80%, stir evenly, left standstill 6-24 hour, filter, filtrate recycling ethanol, and be condensed into thick paste, its relative density is 1.20-1.50 in the time of 90 ℃;
C) paste is carried out dried, get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101123057A CN1973864B (en) | 2006-08-31 | 2006-08-31 | Medicine composition for treating hematuria and nephropyelitis and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101123057A CN1973864B (en) | 2006-08-31 | 2006-08-31 | Medicine composition for treating hematuria and nephropyelitis and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1973864A CN1973864A (en) | 2007-06-06 |
| CN1973864B true CN1973864B (en) | 2010-04-14 |
Family
ID=38124398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006101123057A Expired - Fee Related CN1973864B (en) | 2006-08-31 | 2006-08-31 | Medicine composition for treating hematuria and nephropyelitis and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1973864B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550514B (en) * | 2013-10-23 | 2016-06-22 | 李露青 | A kind of Chinese medicine treating chronic reflux nephropathy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352978A (en) * | 2001-07-16 | 2002-06-12 | 夏伍明 | Medicine 'Shenfeishu' for treating nephrosis and lung disease and its preparing process |
| CN1419927A (en) * | 2001-11-18 | 2003-05-28 | 孙燕明 | Sieral schemes and Chinese medicine preparation for traditional Chinese medicine diagnosis and treatment of nephritis and nephropathy syndrome |
| CN1449777A (en) * | 2002-04-09 | 2003-10-22 | 韩玉昆 | Medicine for treating kidney disease |
-
2006
- 2006-08-31 CN CN2006101123057A patent/CN1973864B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1352978A (en) * | 2001-07-16 | 2002-06-12 | 夏伍明 | Medicine 'Shenfeishu' for treating nephrosis and lung disease and its preparing process |
| CN1419927A (en) * | 2001-11-18 | 2003-05-28 | 孙燕明 | Sieral schemes and Chinese medicine preparation for traditional Chinese medicine diagnosis and treatment of nephritis and nephropathy syndrome |
| CN1449777A (en) * | 2002-04-09 | 2003-10-22 | 韩玉昆 | Medicine for treating kidney disease |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1973864A (en) | 2007-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101164585B (en) | Medicine for curing gout and its preparing method | |
| CN101239112A (en) | Chinese medicinal composition for regulating blood fat and preparation thereof | |
| CN101264217A (en) | Chinese medicine assembly for nourishing yin and tonifying kidney, promoting qi and promoting blood circulation, and relaxing tendons and collaterals | |
| CN101757279B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese eaglewood and preparation method thereof | |
| CN101757281B (en) | Traditional Chinese medicine composition for treating gastrointestinal disease and preparation method thereof | |
| CN102813870A (en) | Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof | |
| CN100509034C (en) | Medicine for treating chronic atrophic gastritis | |
| CN101766780B (en) | Sandalwood-containing traditional Chinese medicine for treating gastrointestinal diseases and preparation method thereof | |
| CN1973850B (en) | Medicine composition for treating allergic rhinitis and its preparation process | |
| CN1973864B (en) | Medicine composition for treating hematuria and nephropyelitis and its preparation | |
| CN106421559A (en) | Traditional Chinese medicine preparation for curing hyperuricemia and preparation method thereof | |
| CN106563076B (en) | Medicine for treating stomach disease and its preparing method | |
| CN101642485B (en) | Application of medical composition containing astragalus root in preparing medicine for treating leucopenia and Henoch-Schonlein Purpura | |
| CN101757288A (en) | Traditional Chinese medicine composition for treating gastrointestinal diseases and preparation method thereof | |
| CN102430008A (en) | Chinese medicinal composition for treating gastrointestinal disease and preparation method thereof | |
| CN101757278B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing costustoot and preparation method thereof | |
| CN101757348B (en) | Traditional Chinese medicine composition for treating gastrointestinal disease and preparation method thereof | |
| CN101134063A (en) | Pharmaceutical composition for liver cirrhosis and method for preparing the same | |
| CN1931318B (en) | Chines medicine composition for treating children rickets and other acalcicosis symptoms and its prepn process | |
| CN115487260B (en) | Traditional Chinese medicine composition for treating hypercholesterolemia or atherosclerosis and application thereof | |
| CN101108229B (en) | Medicament for treating tummy bug | |
| CN101757529B (en) | Gastrointestinal disease-treating traditional Chinese medicine composition containing fructus amomi and preparation method thereof | |
| CN1973871B (en) | Largngopharyngitis treating medicine composition and its preparation | |
| CN102416088B (en) | Chinese medicinal composition for treating gastrointestinal diseases and preparation method thereof | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100414 Termination date: 20120831 |