CN101134063A - Pharmaceutical composition for liver cirrhosis and method for preparing the same - Google Patents
Pharmaceutical composition for liver cirrhosis and method for preparing the same Download PDFInfo
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Abstract
The present invention belongs to the field of medicine technology, and discloses one kind of medicine composition for treating hepatocirrhosis and its preparation process. The medicine composition has the effective components of medicine materials honeysuckle, pangolin scale, rhubarb charcoal and chicken's gizzard membrane. It may be prepared into different preparation forms, preferably orally taken preparation. It has functions of clearing away heat, dispersing clots, and softening and resolving hard mass, and is mainly for treating hepatocirrhosis treating medicine.
Description
1, technical field
The invention belongs to medical technical field, be specifically related to a kind of pharmaceutical composition that is used for liver cirrhosis and preparation method thereof.
2, background technology
Liver cirrhosis is meant hepatic fibrosis and the remaining hepatocellular nodular regeneration that liver tissues inflammatory is downright bad and take place.Viral hepatitis, chronic alcoholism, heredity and metabolic disease, liver blood stasis, chemical toxicant or medicine, malnutrition etc. all can cause the generation of liver cirrhosis.Patient's loss of appetite, (sometimes with feeling sick, vomitting), heating, lassitude and weak, diarrhoea, stomachache, abdomen account, ascites, jaundice, vena epigastrica expansion.Be common in bodily form obesity, malnutrition, have bad physiques, indulge in excessive drinking, suffer from the crowd of hepatitis.
At present, the various diseases of treatment liver cirrhosis mainly are to adopt western medicine therapy, suit the remedy to the case, adopt defeated albumin more, beat hepatic such as diuresis pin and treat,, cure the symptoms, not the disease though can temporarily remove patient's misery, the traditional Chinese medical science adopts determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, but do not treat liver cirrhosis obvious results medicine at present, therefore, develop the target that Chinese patent medicine evident in efficacy has become the scientific research personnel.
The traditional Chinese medical science is thought, the cause of disease of liver cirrhosis mainly is that damp is a trouble, sick position is fade-in blood system based on the liver spleen by edema caused by disorder of QI, and the state of an illness is a deficiency in origin and excess in superficiality, so should first eliminating damp-heat in treatment, damp eliminating is engaged in to the greatest extent, as wet water, the then promote the circulation of qi and water of gathering into, note QI and blood regulating simultaneously, transfer the spleen reinforcing kidney, for deteriorated case treatment according to the specific symptoms then.
Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb. or the flower that band is just opened.Sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing is arranged, the effect of wind-heat dissipating.Be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Squama Manis is the scute of Manidae animal Squama Manis Manis pentadactyla Linnaeus.Salty in the mouth, cold nature.Return liver, stomach warp.The stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, the effect of expel wind to dredge collateral.Be used for Jing Bi WEIJIA, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.Stir-baked SQUAMA MANITIS is a kind of processed product of Squama Manis, and concocting method is for getting clean Squama Manis, size separately, according to the method for scalding with stir-baking in sand to heaving cleaning, drying.Time spent smashs to pieces, gets final product.
Radix Et Rhizoma Rhei is the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.exBalf. or Rheum officinale Rheum officinale Baill..Bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.Purging heat and dredging bowels is arranged, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.Be used for the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, injury from falling down, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Charred Radix Et Rhizoma Rhei is the processed product of Radix Et Rhizoma Rhei, and concocting method is fried to surperficial coke black, inner burnt brown according to the parch to black method for getting clean rhubarb tablets.The hemostasis of charred Radix Et Rhizoma Rhei cooling blood and removing stasis, being used for heat in blood has stasis of blood hemorrhage.
Endothelium Corneum Gigeriae Galli is the dry inner wall of sandbag of the chicken Gallus gallus domesticus Brisson of Phasianidae animal man.Sweet in the mouth, property is flat.Return spleen, stomach, small intestinal, urinary bladder channel.Invigorating the stomach and promoting digestion is arranged, the effect of arresting seminal emission.Be used for food stagnation and do not disappear, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.
At present, utilize Flos Lonicerae, Squama Manis, charred Radix Et Rhizoma Rhei and Endothelium Corneum Gigeriae Galli to interact, composition of prescription is used to prepare the medicine for the treatment of liver cirrhosis, does not appear in the newspapers as yet.
3, summary of the invention
The object of the present invention is to provide that a kind of prescription science that is used for the treatment of liver cirrhosis, preparation are simple, the pharmaceutical composition of determined curative effect.
Blood stagnancy due to deficiency of QI is basis of pathological changes, and the noxious dampness pathogenic heat is delaied blood stasis, and blood stagnation is the cause of disease of hepatic disease in liver.The pent-up of feelings will and impairing the liver, eating and drinking without temperance and the impairment of the spleen, the liver spleen is all empty.Spleen loses fortuneization, involves in kidney, and suffering from a deficiency of the kidney can not warm spleen soil, can not nourish edema with the liver involved, and then liver is more empty, causes stagnation of QI due to depression of the liver, blood-vessel obstructive, retention of water-damp in the body.The three dirty imbalances of liver spleen kidney are the stagnation of QI, blood stasis, water retention then, and it is three dirty that the internal resistance of QI and blood water damages again conversely.So lassitude and weak, loss of appetite appear in liver cirrhosis patient, diarrhoea, abdominal distention, ascites, stomachache, hemorrhage, splenomegaly, hepatomegaly are etc. symptom.
Pharmaceutical composition of the present invention is according to the theoretical composition of prescription of Chinese medicine and pharmacy: the Flos Lonicerae sweet in the mouth, and cold in nature, return lung, the heart, stomach warp, can heat-clearing and toxic substances removing, again can dispelling wind and heat pathogens, have part of the body cavity above the diaphragm housing the heart and lungs noxious dampness heresy clearly, the merit of evacuation of pus detumescence; The Squama Manis salty in the mouth, cold nature is returned liver, stomach warp, the merit benefaction gasification stasis of blood, activating blood and promoting diuresis, detumescence and apocenosis is used for the spleen kidney deficiency, the water blood stasis that wet, assistance Flos Lonicerae inducing diuresis to remove edema is invigorated blood circulation; The Radix Et Rhizoma Rhei bitter in the mouth, cold in nature, return spleen, stomach, large intestine, liver, pericardium channel, charred Radix Et Rhizoma Rhei cooling blood for hemostasis dissipating blood stasis is used for purpura or petechia or hematemesis is arranged; The Endothelium Corneum Gigeriae Galli sweet in the mouth, property is flat, returns spleen, stomach, small intestinal, urinary bladder channel, tool congestion, the long-pending knot that looses, the merit of eliminating mass abdominal mass.Four share soothing the liver, eliminating stagnation, blood stasis dispelling, diuretic, fall detumescence, can be used for liver cirrhosis and follow disease.
To be the inventor through a large amount of experiments grope to sum up the consumption of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention draws, and it consists of: Flos Lonicerae, Squama Manis, charred Radix Et Rhizoma Rhei, Endothelium Corneum Gigeriae Galli.Be preferably: 10～30 parts of Flos Loniceraes, 5～15 parts of stir-baked SQUAMA MANITISs, 5～15 parts of charred Radix Et Rhizoma Rheis, 5～15 parts of Endothelium Corneum Gigeriae Galli.
Make the contained composition and effectiveness of pharmaceutical composition of the present invention crude drug composition more preferably:
15～25 parts of Flos Loniceraes, 8～12 parts of Squama Maniss, 8～12 parts of charred Radix Et Rhizoma Rheis, 8～12 parts of Endothelium Corneum Gigeriae Galli.
The composition of making the crude drug of the contained composition and effectiveness of pharmaceutical composition of the present invention further is preferably:
20 parts of Flos Loniceraes, 10 parts of Squama Maniss, 10 parts of charred Radix Et Rhizoma Rheis, 10 parts of Endothelium Corneum Gigeriae Galli.
Squama Manis in the above-mentioned composition can be given birth to product or processed product for Squama Manis, preferred processed product, and the especially preferred Squama Manis of concocting with the method for scalding is a stir-baked SQUAMA MANITIS.The quality standard of stir-baked SQUAMA MANITIS records in 2005 editions pharmacopeia, and its concocting method is for getting clean Squama Manis, size separately, according to the method for scalding with stir-baking in sand to heaving cleaning, drying.
The crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention is by weight as proportioning, when producing, can or reduce according to the corresponding proportion increase, as large-scale production can kilogram be unit, or be unit with the ton, small-scale production also can restrain and be unit, and weight can increase or reduce.The weight proportion of pharmaceutical composition crude drug of the present invention obtains through science screening, and for especial patient, the ratio of can corresponding adjustment forming increases or reduce being no more than 100%.
Another object of the present invention is to provide this preparation of drug combination method.
In order to make the crude drug of making the contained composition and effectiveness of pharmaceutical composition of the present invention better bring into play drug effect, the invention provides following preparation technology, but be not limited only to following method:
Take by weighing Flos Lonicerae, add 40%～60% ethanol extraction, adding amount of alcohol is 5～10 times of amounts of medical material, and extraction time is 1～3 hour, merge extractive liquid, filters filtrate recycling ethanol, and be evaporated to the extractum of relative density 1.25～1.30, and put vacuum desiccator, 50 ℃～70 ℃ are dried to dried cream; Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, Endothelium Corneum Gigeriae Galli pulverize separately and become granule, cross sieve No. one; Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, Endothelium Corneum Gigeriae Galli granule are ground into fine powder, cross 100 mesh sieves, mixing adds adjuvant and makes preparation.
Above-mentioned preparation method can be preferably following steps:
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing adds adjuvant and makes preparation.
Pharmaceutical composition of the present invention has the effect of heat clearing and blood stasis dispersing, hard masses softening and resolving, is mainly used in the medicine of preparation treatment liver cirrhosis.
Pharmaceutical composition of the present invention can be mixed and made into clinically any or pharmaceutically acceptable dosage form, preferred oral preparation with one or more pharmaceutically acceptable carriers.Be used for when oral, can be made into conventional solid preparation, as tablet, capsule, pill, granule etc.Tablet means disk shape or the special-shaped flaky solid preparation that medicine and the auxiliary materials and mixing compacting that suits form, based on oral ordinary tablet, other has buccal tablet, Sublingual tablet, mouth paster, chewable tablet, dispersible tablet, fuse, effervescent tablet, slow releasing tablet, controlled release tablet and enteric coatel tablets etc.Capsule means medicine or is added with the adjuvant filling in Capsules or be sealed in solid preparation in the soft capsule material, according to its dissolving and release characteristics, can be divided into hard capsule (being commonly referred to as capsule), soft capsule (soft gelatin capsule), slow releasing capsule, controlled release capsule and enteric coated capsule etc.Pill means medicine and suitable adjuvant uniform mixing, and the spherical or near-spherical solid preparation so that proper method is made comprises drop pill, sugar pill, piller etc.Granule means that medicine and suitable adjuvant make the dried particles shape preparation with certain particle size, can be divided into soluble particles (being commonly referred to as granule), mix suspension grain, effervescent granule, enteric coated particles, slow-releasing granules and controlled release granule etc.
When pharmaceutical composition of the present invention is made oral formulations, can add suitable filler, binding agent, disintegrating agent, lubricant etc.Filler commonly used comprises starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Typical binders comprises sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Disintegrating agent commonly used comprises dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Conventional lubricants comprises magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of pharmaceutical composition of the present invention is:
(1) provide a kind of liver cirrhosis that is used for the treatment of, especially disease is seen the pharmaceutical composition of stomachache, ascites, hemorrhage, hepatosplenomegaly, has increased the clinical application kind, has satisfied clinical needs;
(2) the pharmacology clinical experiment shows, medicine composite for curing liver cirrhosis effect of the present invention is remarkable, and effect that medicine of the present invention reaches is that those of ordinary skills are beyond thought.
(3) pharmaceutical preparation of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below routine by experiment beneficial effect of further setting forth the pharmaceutical composition of making by Flos Lonicerae, stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei and Endothelium Corneum Gigeriae Galli.
Experimental example 1 pharmaceutical composition of the present invention is to the influence of rat serum hepatic fibrosis
Animal subject: SD male rat, body weight 180～200g, 90.
Test sample and reagent: medicament composition granule agent of the present invention: preparation method and prescription are seen embodiment 1 prescription 1; Colchicine (Laboratrise Houde company product): it is frozen standby to be made into 0.01mg/ml solution with normal saline.
Experimental technique: rat is divided into 5 groups at random: pharmaceutical composition low dose group of the present invention (dosage group in 2.5g crude drug/kg), the pharmaceutical composition of the present invention (5g crude drug/kg), pharmaceutical composition high dose group of the present invention (7.5g crude drug/kg), colchicine group, model group and normal control group, every group of 15 rats.
Modeling: replace subcutaneous injection 50%CCL in rat bilateral hypogastric zone
4Rapeseed oil solution, dosage 0.2ml/100g body weight, on every Mondays, Friday each once, inject altogether 16 times, use for diseases caused by retention of fluid with 5% ethanol every day simultaneously.The not modeling of normal control group is normally raised.With the medicinal granule physiological saline solution, each administration group is all by 2ml/100g body weight gastric infusion in modeling, and the colchicine group is pressed the 2ml/100g body weight and irritated the stomach colchicine, and model group, normal control group are irritated stomach and given normal saline 2ml/100g.To modeling after 60 days, get rat liver and blood specimen under the etherization, conventional treatment.
The comparison of rat serum hepatic fibrosis index (X ± S)
| Group | HA(ng/ml) | IV-C(ng/ml) |
| Dosage group pharmaceutical composition high dose group of the present invention colchicine group model group normal control group in the pharmaceutical composition low dose group of the present invention pharmaceutical composition of the present invention | 342.2±57.82 *335.3±56.74 **326.1±56.86 **368.3±55.94 *456.12±59.38 ##92.7±32.68 | 29.91±6.84 *28.56±7.85 *26.86±7.63 **29.97±7.19 *39.10±8.24 ##23.56±3.98 |
Annotate:
*P＜0.05,
*P＜0.01 is with the model group ratio;
##P＜0.01 is with normal control group ratio.Experimental result and discussion: compare with the normal control group, model group HA, IV-C extremely significantly raise (p＜0.01), and the modeling success is described.Compare with model group, the HA of each administration group, IV-C all significantly reduce (p＜0.05, p＜0.01), and pharmaceutical composition low dose group of the present invention, middle dosage group, high dose group HA, IV-C reduce amplitude and increase successively; It is suitable with the colchicine group that low dose group reduces amplitude, and it is big than the colchicine group that middle and high dosage group reduces amplitude.Show that hepatic fibrosis has effect more significantly to pharmaceutical composition of the present invention for rat serum.
The clinical efficacy data of experimental example 2 pharmaceutical compositions of the present invention
Physical data: 125 routine patients, male's 64 examples wherein, women's 61 examples; The oldest 70 years old, minimum 21 years old, average 45 years old; The course of disease the shortest June, the longest 20 years, average 10 years.All cases are all made a definite diagnosis through clinical diagnosis.Clinical manifestation mainly contains stomachache, abdominal distention, ascites, hepatosplenomegaly etc.
Therapeutic Method: embodiment 1 prescription 1 is seen in oral medicament composition granule agent of the present invention, preparation method and prescription.Patient takes the medicament composition granule agent, takes the dosage that is equivalent to crude drug 25g at every turn, one day 2 doses.Take medicine equal 30 days be 1 course of treatment, took for 1 course of treatment after, observe the curative effect after 3 courses of treatment is taken in drug withdrawal 5 days altogether.
Criterion of therapeutical effect: recovery from illness: clinical symptom disappearance, liver function (ALT, TBil, A/G or protein electrophoresis) recover normal.Produce effects: ascites disappears, and hepatosplenomegaly is stablized constant, does not have pain of kowtowing and tenderness, liver function index decline 75%-85%.Effectively: the liver function index fall is more than 50% and normal fully.Invalid: clinical symptoms remains unchanged, and liver function index does not have significant change.
Therapeutic outcome: after 3 course of therapy, 16 examples of fully recovering, produce effects 45 examples, effective 51 examples, invalid 13 examples, total effective rate 89.6%.
Conclusion: above clinical experiment result shows that this pharmaceutical composition has good curative effect to liver cirrhosis.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of medicament composition granule agent of the present invention
Prescription 1: Flos Lonicerae 20g stir-baked SQUAMA MANITIS 10g charred Radix Et Rhizoma Rhei 10g Endothelium Corneum Gigeriae Galli 10g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, adds binding agent, disintegrating agent and lubricant and makes granule.
Prescription 2: Flos Lonicerae 25g stir-baked SQUAMA MANITIS 8g charred Radix Et Rhizoma Rhei 12g Endothelium Corneum Gigeriae Galli 8g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, adds binding agent, disintegrating agent and lubricant and makes granule.
Embodiment 2: the system of pharmaceutical composition tablet of the present invention respectively
Prescription 1: Flos Lonicerae 15g stir-baked SQUAMA MANITIS 8g charred Radix Et Rhizoma Rhei 8g Endothelium Corneum Gigeriae Galli 12g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, and add binding agent, disintegrating agent and lubricant and make granule, drying, compacting is in flakes.
Prescription 2: Flos Lonicerae 25g stir-baked SQUAMA MANITIS 12g charred Radix Et Rhizoma Rhei 8g Endothelium Corneum Gigeriae Galli 8g
Claim Flos Lonicerae, add 75% ethanol extraction secondary, add 10 times of amounts of 75% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 75% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Get the charred Radix Et Rhizoma Rhei coarse powder, adding 5 times of amount 0.2mol/ml hydrochloric acid refluxed 2 hours in 100 ℃ of heating in water bath, filter, filtrate is with becoming thick paste with the back concentrating under reduced pressure among the 2%NaOH, 100 ℃ of water-bath reflux, extract, of reuse ethanol 3 times, (each 2 times of amount crude drugs) merging ethanol liquid, decompression recycling ethanol, be concentrated into relative density 1.18～1.22, vacuum drying obtains the dried cream of charred Radix Et Rhizoma Rhei.Take by weighing stir-baked SQUAMA MANITIS, Endothelium Corneum Gigeriae Galli, the dried cream of charred Radix Et Rhizoma Rhei, Getrocknete Blumen cream, drying is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, and add binding agent, disintegrating agent and lubricant and make granule, drying, compacting is in flakes.
Embodiment 3: the preparation of medicament composition capsule agent of the present invention
Prescription 1: Flos Lonicerae 18g stir-baked SQUAMA MANITIS 7g charred Radix Et Rhizoma Rhei 10g Endothelium Corneum Gigeriae Galli 12g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, adds binding agent, disintegrating agent and lubricant and makes granule, the hard capsule of packing into.
Prescription 2: Flos Lonicerae 20g stir-baked SQUAMA MANITIS 11g charred Radix Et Rhizoma Rhei 9g Endothelium Corneum Gigeriae Galli 10g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, and mixing gets medicated powder, adds binding agent, disintegrating agent and lubricant and makes granule, the hard capsule of packing into.
Embodiment 4: the system of medicinal composition soft capsule agent of the present invention respectively
Prescription 1: Flos Lonicerae 25g stir-baked SQUAMA MANITIS 15g charred Radix Et Rhizoma Rhei 14g Endothelium Corneum Gigeriae Galli 13g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, mixing, medicated powder, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put coldly, adds medicated powder, is pressed into soft capsule.
Prescription 2: Flos Lonicerae 16g stir-baked SQUAMA MANITIS 8g charred Radix Et Rhizoma Rhei 13g Endothelium Corneum Gigeriae Galli 8g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, crosses 100 mesh sieves, mixing, medicated powder, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put coldly, adds medicated powder, is pressed into soft capsule.
Embodiment 5: the preparation of medicament composition dropping pills of the present invention
Prescription 1: Flos Lonicerae 22g stir-baked SQUAMA MANITIS 13g charred Radix Et Rhizoma Rhei 13g Endothelium Corneum Gigeriae Galli 12g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, cross 100 mesh sieves, mixing gets medicated powder, with polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Prescription 2: Flos Lonicerae 18g stir-baked SQUAMA MANITIS 8g charred Radix Et Rhizoma Rhei 9g Endothelium Corneum Gigeriae Galli 9g
Claim Flos Lonicerae, add 50% ethanol extraction secondary, add 10 times of amounts of 50% ethanol for the first time, extracted 2 hours, add for the second time 8 times of amounts of 50% ethanol, decocted 1.5 hours, merge extractive liquid, filters, filtrate recycling ethanol, being evaporated to relative density is 1.20～1.25, puts vacuum desiccator, and 60 ℃ are dried to dried cream.Take by weighing stir-baked SQUAMA MANITIS, charred Radix Et Rhizoma Rhei, pulverize separately and become granule, cross sieve No. one; Take by weighing Endothelium Corneum Gigeriae Galli, dry, be ground into granule, cross sieve No. one; With Getrocknete Blumen cream, stir-baked SQUAMA MANITIS granule, charred Radix Et Rhizoma Rhei granule, the Endothelium Corneum Gigeriae Galli granule is ground into fine powder, cross 100 mesh sieves, mixing gets medicated powder, with polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves are filtered, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Claims (8)
1. a pharmaceutical composition that is used for liver cirrhosis is characterized in that, makes the consisting of of crude drug of the contained active ingredient of this pharmaceutical composition: Flos Lonicerae, Squama Manis, charred Radix Et Rhizoma Rhei, Endothelium Corneum Gigeriae Galli.
2. a pharmaceutical composition that is used for liver cirrhosis is characterized in that, makes the consisting of of crude drug of the contained active ingredient of this pharmaceutical composition: 10～30 parts of Flos Loniceraes, 5～15 parts of Squama Maniss, 5～15 parts of charred Radix Et Rhizoma Rheis, 5～15 parts of Endothelium Corneum Gigeriae Galli.
3. pharmaceutical composition according to claim 1 is characterized in that, makes the consisting of of crude drug of the contained active ingredient of this pharmaceutical composition: 15～25 parts of Flos Loniceraes, 8～12 parts of Squama Maniss, 8～12 parts of charred Radix Et Rhizoma Rheis, 8～12 parts of Endothelium Corneum Gigeriae Galli.
4. pharmaceutical composition according to claim 2 is characterized in that, makes the consisting of of crude drug of the contained active ingredient of this pharmaceutical composition: 20 parts of Flos Loniceraes, 10 parts of Squama Maniss, 10 parts of charred Radix Et Rhizoma Rheis, 10 parts of Endothelium Corneum Gigeriae Galli.
5. the described arbitrary pharmaceutical composition of claim 1～4 is characterized in that, Squama Manis wherein can make a living product or processed product, processed product comprise that the Squama Manis of concocting with the method for scalding is a stir-baked SQUAMA MANITIS.
6. the described arbitrary pharmaceutical composition of claim 1～4 is characterized in that Squama Manis wherein can replace with stir-baked SQUAMA MANITIS.
7. according to the described arbitrary pharmaceutical composition of claim 1～4, it is characterized in that this pharmaceutical composition can be made arbitrary preparation with mixing acceptable accessories.
8. pharmaceutical composition according to claim 8 is characterized in that this pharmaceutical composition can be made oral formulations with mixing acceptable accessories.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100687264A CN100563678C (en) | 2006-09-01 | 2006-09-01 | Be used for pharmaceutical composition of liver cirrhosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100687264A CN100563678C (en) | 2006-09-01 | 2006-09-01 | Be used for pharmaceutical composition of liver cirrhosis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101134063A true CN101134063A (en) | 2008-03-05 |
| CN100563678C CN100563678C (en) | 2009-12-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2006100687264A Expired - Fee Related CN100563678C (en) | 2006-09-01 | 2006-09-01 | Be used for pharmaceutical composition of liver cirrhosis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494907A (en) * | 2013-09-26 | 2014-01-08 | 河南中医学院第一附属医院 | Liver cirrhosis softening pill for treating liver cirrhosis in compensatory stage |
| CN107569637A (en) * | 2017-09-01 | 2018-01-12 | 赣州市青衫堂中草药有限公司 | Chinese medicine composition for treating hepatic sclerosis and preparation method and application |
| CN110840917A (en) * | 2019-12-19 | 2020-02-28 | 湖南大诚中药生物有限责任公司 | Processing technology of traditional Chinese medicine decoction pieces for processing pangolin scales |
-
2006
- 2006-09-01 CN CNB2006100687264A patent/CN100563678C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103494907A (en) * | 2013-09-26 | 2014-01-08 | 河南中医学院第一附属医院 | Liver cirrhosis softening pill for treating liver cirrhosis in compensatory stage |
| CN107569637A (en) * | 2017-09-01 | 2018-01-12 | 赣州市青衫堂中草药有限公司 | Chinese medicine composition for treating hepatic sclerosis and preparation method and application |
| CN110840917A (en) * | 2019-12-19 | 2020-02-28 | 湖南大诚中药生物有限责任公司 | Processing technology of traditional Chinese medicine decoction pieces for processing pangolin scales |
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| CN100563678C (en) | 2009-12-02 |
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