CN1209338A - Analgesic-antipyretic medicine and preparing method therefor - Google Patents
Analgesic-antipyretic medicine and preparing method therefor Download PDFInfo
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- CN1209338A CN1209338A CN 98118792 CN98118792A CN1209338A CN 1209338 A CN1209338 A CN 1209338A CN 98118792 CN98118792 CN 98118792 CN 98118792 A CN98118792 A CN 98118792A CN 1209338 A CN1209338 A CN 1209338A
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Abstract
The present invention relates to an antipyretic analgesic and its preparation method. It is characterized by using the Chinese medicine pueraria root and taurine as main medicinal material added with auxiliary medicinal material according to the mixing ratio (weight portion) of pueraria root and taurine of 0.5-50 : 0.05-5 which are made into oral liquor or tablet or enteroclysm according to the conventional process. Said invention is high in safety, good in taste, obvious in therapeutic effect, specially is suitable for curing the common diseases of child fever caused by upper respiratory tract infection.
Description
The present invention relates to a kind of pharmaceutical composition, especially a kind of by in, the medicine formed of Western medicine and the preparation method of this medicine.
Cold, fever is one of human modal disease, and the child is in growth and development stage, and their ability of resist the disease is lower, and the chance of therefore suffering from respiratory tract infection is more, and the antipyretic analgesic of for this reason developing a kind of child of being applicable to is necessary.Antipyretic analgesic commonly used clinically now is compound preparation mostly, and the main component of their Western medicine has acetaminophen (PCI), aspirin (ASA), phenacetin, aminophenazone, anodynine etc.Wherein Compound Amidopyrin Injection is to use the very high antipyretic of rate, and its prescription is aminophenazone and anodynine, and because of their toxicity is bigger, its single preparations of ephedrine has been announced by China's Ministry of Public Health in nineteen eighty-two and eliminated, but compound preparation is still used till today, and its safety is worth us to consider.Next is a children's APC sheet, its prescription is ASA, phenacetin and caffeine, ASA produces the possible of child Reye syndrome in European and American countries because of having, advise careful usefulness or forbidding, phenacetin has remarkable untoward reaction because of it to blood system, also being announced by China Ministry of Public Health in 82 years and eliminate that this compound preparation with potential danger is used for the clinical treatment of child's heating more at large, should be when causing our attention.See some preparations that contain PCI again, as Chinese medicine and western medicine bonding agent WEI C YINQIAO PIAN (electuary), folk prescription as snap one FR and paracetamol etc., also higher utilization rate arranged clinical, PCI is suitable for the range of age the child, expert both domestic and external has different views, the famous pharmacy expert of China thinks child below 3 years old and neonate because of liver, renal function hypoplasia, should avoid using.SHUANGHUANLIAN is a pure Chinese medicinal preparation, and higher utilization rate is also arranged clinically, and the report of its injection ADR is many, local excitation symptom (phlebitis), anaphylaxis (dizzy, nauseating), anaphylactoid purpura is arranged even the anaphylactic shock phenomenon takes place.Though its oral liquid loses the report of ADR, have bitterness in its mouthfeel, often be difficult for generally being accepted by the child.
Radix Puerariae is as herbal species that records of China's pharmacopeia, the property flat, sweet in the mouth is hot, belong to wind-heat-dispersing medicinal, tool expelling pathogenic factors from muscles for reducing heat, the saturating class of sending out rash, inspire and defend gas, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal effect,, diarrhea due to hypofunction of the spleen saturating and the key medicine of quenching one's thirst for the heating of treatment exterior syndrome, headache stiffness of the nape, class's rash.The GEGEN TANG system that " Treatise on Febrile Diseases " carried in the source is made up of seven flavor medicines such as Radix Puerariae, Herba Ephedrae, Ramulus Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubaes, and aversion to cold, hyperpyrexia are had tangible curative effect.Occur one after the GEGEN TANG and cross untoward reaction such as property is felt sick, vomiting, fatigue, constipation but be reported in to take, very then treat the case that AGML occurs of catching a cold and report because of taking the GEGEN TANG extractant.Yufeng ningxin tablets, yufeng ningxin pian (or oral liquid) so that the Radix Puerariae folk prescription is made is used for the treatment of diseases such as hypertension dizziness, headache, neck pain, coronary heart disease, angina pectoris, nervous headache, early sudden deafness.Yufeng ningxin tablets, yufeng ningxin pian is not seen above-mentioned gastral ADR report as yet through long-term clinical use, can think that folk prescription Radix Puerariae Chinese medicine uses safer than compound recipe.But the Radix Puerariae single preparations of ephedrine is not seen the clinical antipyretic report that is used for again.
The object of the present invention is to provide a kind of by in, Western medicine combination, have the function of definitely bringing down a fever, safety is better, and on mouthfeel easily for the child accepts, be particularly useful for the child and go up the antipyretic of feeling commonly encountered diseases such as heating.
The scheme that the object of the invention realizes is: the medicine that is provided is made up of Radix Puerariae and taurine, and the proportioning of Radix Puerariae and taurine (weight, part) is 0.5~50: 0.05~5.
Medicine Radix Puerariae of the present invention is 1~10 with the most adaptive of taurine than (weight, part): 0.1~1.
The preparation method of medicine of the present invention is: powder of Radix Puerariae is broken into coarse powder, uses the alcohol reflux secondary, merge extractive liquid, reclaims ethanol and is concentrated into certain volume, filter, filtrate adds taurine and simple syrup, and adds water to required amount of preparation, fine straining, packing, sterilization promptly gets oral liquid; Or after reclaiming ethanol, extracting solution is concentrated into the thick paste shape, adds appropriate amount of auxiliary materials, and electuary or tablet are made in the granulation of sieving again according to a conventional method, can reduce the cost of packing, material like this.
Medicine of the present invention can substitute simple syrup with an amount of glycerol, make enema, be used for coma due to high fever, can not be oral the patient.
One of drug component of the present invention Radix Puerariae is the tuber of legume pueraria lobata Pueraria lobata (willd.) Ohwi, substitutes Herba Gelsemii Elegantis as the tuber with Radix Puerariae rattan Pueraria tlomsonii Benth, and consumption then need double; Taurine is one of main effective ingredient of Chinese medicine Calculus Bovis, because of its chemical constitution fairly simple, synthetic production now, the taurine of the first-selected synthetic of the present invention does not have equal effect but do not get rid of Calculus Bovis.
The present invention selects the medicine of Radix Puerariae and taurine compatibility for use, proves the good synergistic that is combined with of two medicines through pharmacological evaluation, and toxicological experiment confirms that again the toxicity of this medicine is very little, and higher safety is arranged, and its experimental result is as follows:
1. the pharmacological evaluation of refrigeration function
Getting body weight is the Wistar rat (being female unpregnancy) of 100-180g, measure the anus temperature 2 times with the glass clinical thermometer, each half an hour at interval, with the basal body temperature of meansigma methods as animal, discard twice body temperature and differ rat more than 0.5 ℃, be divided into three groups by body temperature then, 8 every group, irritate the concentrated solution (every ml contains Radix Puerariae 0.83g and taurine 0.05g) that stomach is given 1. this preparation of 1.5ml/100g respectively; 2. the WEI C YINQIAO PIAN aqueous suspension of 1/6ml is made positive control), 1. 2. two groups of 50 times of being clinical dosage; 3. make blank with distilled water.Each organizes subcutaneous injection pyrogenicity agent immediately (0.3% 2.4-dinitrophenol,DNP) 15mg/kg after the administration, writing time simultaneously, surveys the anus temperature of 0.5h, 1.0h, 1.5h, 2.0h, 3.0h, 4.0h, 5.0h, 6.0h, 8.0h then respectively.Calculate behind the medicine with medicine before difference, determine result's significant difference with the t method of inspection.The results are shown in Table 1
By table 1 as seen, this preparation 0.5h behind medicine has begun to play a role, 0.5h (P<0.05), 1.0h (P<0.01), 1.5h (P<0.01) effect obviously, can suppress the heating that the 2.4-dinitrophenol,DNP causes significantly and be lower than basal body temperature, still can gently suppress fervescence behind the 2h.WEI C YINQIAO PIAN positive controls 1~6h behind medicine also can faintly suppress fervescence, but compares there was no significant difference (P>0.05) with the blank group.The result shows that the refrigeration function of this preparation compares in conjunction with the preparation WEI C YINQIAO PIAN with similar Chinese and Western commonly used, and the former effect is better than the latter.
2. the experiment of this preparation and two component pharmacological actions
This experiment is divided into four groups; 1. be the blank group; 2. be taurine group (every ml contains the 0.05g taurine); 3. Radix Puerariae extracting solution group (every ml contains Radix Puerariae 0.83g); 4. this preparation group (every ml contains Radix Puerariae 0.83g, taurine 0.05g); the method of the method for other groupings, the dose of rat oral gavage, experiment and observation thereof all pharmacological testing with above-mentioned antipyretic effect is identical, experimental result such as table 2.
Can find out and the isodose two component groups of this preparation from table 2; be taurine group and Radix Puerariae extracting solution group; all subcutaneous injection 2.4 dinitrophenol,DNP are caused that rat temperature raises and to have certain inhibitory action trend, but with the relatively equal not statistically significant (P>0.05) of blank group.This preparation group can obviously suppress the fervescence (P<0.05, P<0.01) of rat in 0.5-1.5h.The result shows that two components (Radix Puerariae and taurine) of this preparation have cooperative effect to refrigeration function.
3. acute toxicity test
(body weight 20 ± 2g), male and female half and half are divided into three groups at random by sex, body weight, and every group 10 table 1 organized medicine to 2, and 2, 4-dinitrophenol causes the influence (X ± S) of rat fervescence for 30 of Kunming kind white mice
Annotate: 1. the body temperature measured value 2. behind the medicine with medicine precursor temperature approach
Group | Number of animals | Body temperature before the medicine | Body temperature behind the medicine | |||||||||
????0.5h | ????1.0h | ????1.5h | ????2.0h | ????3.0h | ????4.0h | ????5.0h | ????6.0h | ????8.0h | ||||
The blank group | 8 | Measured value ① | 38.12±0.47 | 38.46±0.52 | 38.50±0.43 | 38.54±0.28 | 38.54±0.2 | 38.32±0.30 | 38.32±0.22 | 38.34±0.42 | 38.19±0.21 | 38.20±0.44 |
The △ value ② | ??0.34 | ??0.38 | ??0.42 | ??0.42 | ??0.20 | ??0.20 | ?0.22 | ?0.07 | ?0.08 | |||
The WEI C YINQIAO PIAN group | 8 | Measured value | 38.10±0.60 | 38.61±0.44 | 38.42±0.90 | 38.21±0.47 | 38.20±0.61 | 38.21±0.48 | 37.96±0.43 | 38.08±0.39 | 38.01±0.47 | 38.40±0.31 |
The △ value | ??0.51 | ??0.32 | ??0.11 | ??0.10 | ??0.11 | ??0.14 | ?0.02 | ??0.06 | ??0.30 | |||
This preparation group | 8 | Measured value | 38.08±0.75 | 37.21±0.84 | 37.70±0.34 | 37.71±0.52 | 37.08±0.61 | 37.94±0.56 | 37.94±0.43 | 37.86±0.49 | 38.14±0.54 | 38.24±0.55 |
The △ value | ??0.87 ④ | ??0.38 ④ | ??0.37 ④ | ??0.1 | ??0.14 | ??0.14 | ?0.22 | ??0.06 | ?0.16 |
With more 3. P<0.05 of blank group, 4. P<0.01 this preparation of table 2 and each component be to 2, and 2, 4-dinitrophenol causes the influence (X ± S) of rat fervescence
Annotate: 1. the body temperature measured value 2. behind the medicine with more 3. P<0.05 of medicine precursor temperature approach and matched group, 4. P<0.01, the dose of the tolerant Cmax of the oral mice of difference, maximum volume (oral 0.6ml calculates with the mice of 20g body weight), the oral dose of this preparation group and positive control WEI C YINQIAO PIAN suspension group all is equivalent to 300 times of clinical dosage.The blank group is the distilled water of oral equal volume then.Normally raised for 1 week (7 days) then, observe and respectively organize the mice active situation, write down death toll, do the pathologic finding of vitals.
Group | Number of animals | Body temperature before the medicine | Body temperature behind the medicine | ||||
????0.5h | ????1.0h | ????1.5h | ????2.0h | ||||
The blank group | ????6 | Measured value ①38.51±0.32 | ?38.95±0.34 | ?39.43±0.71 | ?39.28±0.68 | ?39.10±0.56 | |
The △ value ② | ????0.44 | ????0.92 | ????0.77 | ????0.59 | |||
The taurine group | ????6 | Measured value 38.52 ± 0.42 | ?38.23±0.63 | ?38.65±0.24 | ?38.70±0.18 | ?38.70±0.31 | |
The △ value | ????-0.29 | ????0.13 | ????0.18 | ????0.18 | |||
The Radix Puerariae extracting solution group | ????6 | Measured value 38.53 ± 0.34 | ?38.40±0.38 | ?38.88±0.26 | ?38.63±0.52 | ?38.92±0.45 | |
The △ value | ????-0.13 | ????0.35 | ????0.1 | ????0.39 | |||
Wooden dose of group | ????6 | Measured value 38.60 ± 0.60 | ?38.07±0.41 | ?38.57±0.92 | ?38.42±0.48 | ?38.55±0.41 | |
The △ value | ????-0.53 ④ | ????-0.03 ③ | ????-0.18 ③ | ????-0.05 |
Experimental result: each 10 mice of (1) this preparation group and blank group all do not have death, and mortality rate is 0%; 9 dead mouses appear in the WEI C YINQIAO PIAN positive controls, and mortality rate is 90%.
(2) the outward appearance active situation of each group shows as: this preparation group mice generally occurs drowsiness, can recover normal activity after 2 days; Show behind the WEI C YINQIAO PIAN positive controls medicine: the movable minimizing, inappetence, lethargy, death totally 9 mices appear in the horrified tarnish of hair in 24 hours; Blank group outward appearance and active situation are all acted normally.
(3) the vitals pathological examination results is: the section of 1 week of this preparation group experiment mice back dissection hepatic pathology, and microscopy hepatic tissue cell form is normal substantially; WEI C YINQIAO PIAN positive controls hepatic tissue section, the microscopy result is: a large amount of cavitys appear in liver cytoplasm between central veins of hepatic lobules expansion, sinus hepaticus congestion, a matter vasodilation and hyperemia, two lobules of liver veins, show hepatic cell fattydegeneration.
Conclusion: this preparation is when 300 times of clinical dosages, and none death of test mice shows that this product toxicity is very little, compares in conjunction with the preparation WEI C YINQIAO PIAN with similar Chinese and Western, and higher safety is arranged.
Three, a clinical trial phase
The Guangxi district worker children of the People's Hospital by taking this preparation voluntarily show that to the trial state of infant 8 examples of fever caused by exogenous pathogens it is rapid that this product has the effect of bringing down a fever, action temperature and, lasting, and have no adverse reaction.Model case: Tan *, woman, 5 years old, because of upper respiratory tract infection, generated heat 3 days, body temperature is persistent more than 39 ℃, through with Compound Amidopyrin Injection intramuscular injection, and oral children's APC sheet and paracetamol dry syrup, body temperature does not still fall, and lives into my institute's pediatric ward treatment and observes, and begins to take 1 in this preparation (10ml) the 3rd day evening 9 more, body temperature began to drop to about 38 ℃ after 10 of that night, and can be quiet sleeping, obey 1 in this preparation midnight again more than 2, and body temperature is promptly reduced to normally after daybreak.
Embodiment:
1. get Radix Puerariae 1kg and be ground into coarse powder; use 60% alcohol reflux 2 times of 7 times, 5 times amounts respectively; time was respectively 3 hours, 2 hours; merge extractive liquid; recovery ethanol also is concentrated into about 600ml; add 300ml simple syrup and taurine 10g and add water to 1000ml, stir evenly, fine straining, the packing sterilization promptly gets oral liquid.
2. get Radix Puerariae 100g and taurine 100g, make this oral liquid 1000ml, technology and method are with embodiment 1.
3. get Radix Puerariae 500g and taurine 50g, make this oral liquid 1000ml, technology and compound method are with embodiment 1.
4. get Radix Puerariae 300g and be ground into coarse powder; with 60% alcohol reflux of 8 times and 6 times amounts 2 times; time was respectively 3 hours and 2 hours, merge extractive liquid, and reclaim ethanol after, be concentrated into 800ml; add glycerol 100ml and taurine 30g; add water to 1000ml, mixing, fine straining; packing, sterilization promptly gets enema.
5. get Radix Puerariae 400g and taurine 30g, extraction is identical with enforcement 1 with compound method, and difference is after reclaiming ethanol, and extracting solution is concentrated into the thick paste shape, adds an amount of Icing Sugar adjuvant, and sieving granulates makes electuary according to a conventional method.
6. get Radix Puerariae 400g and be ground into coarse powder, use 60% alcohol reflux 2 times of 7 times, 5 times amounts respectively, the time was respectively 3 hours, 2 hours, and merge extractive liquid, reclaims ethanol and also is concentrated into the thick paste shape, adds an amount of Icing Sugar adjuvant, sieved and made electuary after granulating.
7. get Radix Puerariae 400g and taurine 40g, make tablet after granulating by the process of embodiment 5.
8. get Radix Puerariae 50g and taurine 500g, make tablet by the process of embodiment 7.
9. get Radix Puerariae 50g and taurine 0.05g, make oral liquid by the process of embodiment 1.
Claims (7)
1. the medicine with antipyretic-antalgic effect contains the Radix Puerariae composition.It is characterized in that being equipped with adjuvant by Radix Puerariae and taurine forms, the proportioning of Radix Puerariae and taurine (weight, part) is 0.5~50: 0.05~5.
2. according to the described medicine of claim 1, it is characterized in that the proportioning (weight, part) of Radix Puerariae and taurine is 1~10: 0.1~1.
3. according to the described medicine of claim 1, it is characterized in that making oral liquid by Radix Puerariae, taurine proportioning simple syrup and water.
4. according to the described medicine of claim 1, it is characterized in that being equipped with glycerol by Radix Puerariae, taurine makes enema.
5. according to the described medicine of claim 1, it is characterized in that being equipped with Icing Sugar by Radix Puerariae, taurine makes electuary.
6. according to the described medicine of claim 1, it is characterized in that being equipped with starch, disintegrating agent and lubricant by Radix Puerariae, taurine makes tablet.
7. process for preparing medicine with antipyretic-antalgic effect comprises that the ethanol extraction of Chinese medicinal ingredients reclaims, concentrates, slurrying or granulation or tabletting process, it is characterized in that Radix Puerariae is added taurine after reclaiming thickening filtration and mixes through extracting.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100431548C (en) * | 2005-12-01 | 2008-11-12 | 广州中医药大学 | Chinese medicine composition for treating cold fever and liver damage and its preparing method |
CN100435803C (en) * | 2006-06-07 | 2008-11-26 | 广州中医药大学 | Use of taurine in preparation of injection containing puerarin |
CN101062027B (en) * | 2006-04-29 | 2010-11-17 | 山东轩竹医药科技有限公司 | Taurine and medical combination for treating cardiovascular and cerebrovascular diseases |
CN111366549A (en) * | 2020-03-24 | 2020-07-03 | 广西壮族自治区人民医院 | Method for measuring content of total saponins in red kiwi fruits |
-
1998
- 1998-09-03 CN CN98118792A patent/CN1066064C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100431548C (en) * | 2005-12-01 | 2008-11-12 | 广州中医药大学 | Chinese medicine composition for treating cold fever and liver damage and its preparing method |
CN101062027B (en) * | 2006-04-29 | 2010-11-17 | 山东轩竹医药科技有限公司 | Taurine and medical combination for treating cardiovascular and cerebrovascular diseases |
CN100435803C (en) * | 2006-06-07 | 2008-11-26 | 广州中医药大学 | Use of taurine in preparation of injection containing puerarin |
CN111366549A (en) * | 2020-03-24 | 2020-07-03 | 广西壮族自治区人民医院 | Method for measuring content of total saponins in red kiwi fruits |
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