CN1640439A

CN1640439A - Method for preparing oral tablet

Info

Publication number: CN1640439A
Application number: CN 200410002345
Authority: CN
Inventors: 王文博; 徐丽君; 江德盛
Original assignee: Zhejiang Dade Pharmaceutical Group Co Ltd
Current assignee: Zhejiang Dade Pharmaceutical Group Co Ltd
Priority date: 2004-01-09
Filing date: 2004-01-09
Publication date: 2005-07-20

Abstract

The present invention relates to an oral lozenge preparation. It is made up by using Chinese medicinal materials of American ginseng and dendrobium stem as main raw material and adding auxiliary materials of magnesium stearate and menth a camphor through a certain preparation process. Said invention also provides the concrete steps of said preparation process. Said said lozenge preparation can be made into health-care food and medicine.

Description

A kind of preparation method of buccal tablet

Technical field the present invention relates to a kind of buccal tablet, mainly is made up of Radix Panacis Quinquefolii, Herba Dendrobii and adjuvant.

In this health food of background technology, Herba Dendrobii is an orchid, and the property slightly sweet flavor is little salty, and is cold.Have the stomach reinforcing of promoting the production of body fluid, clearing away heat and nourishing YIN is controlled consumption of body fluid caused by febrile disease, the xerostomia excessive thirst, and deficiency-heat after being ill, the moon is hindered the dark effect of order.Be usually used in serious disease, urgent patient clinically, reach the rehabilitation after cancer patient is treated and be used for symptoms such as laryngopharynx swelling and pain, hoarseness, fuzzy viewing.Modern medicine study shows that isolating polysaccharose substance is a kind of important immunomodulator from Herba Dendrobii, can significantly improve the immunoloregulation function of body, and the effect that delays senility of humanbody is arranged; The Radix Panacis Quinquefolii sweet and slightly bitter taste, cold.But lung benefiting the moon, clear asthenic fire promoting the production of body fluid to quench thirst.Control chronic cough of deficiency lung, lose blood, dry throat and mouth, deficiency-heat is tired tired." Bencao Congxin " record: " relieving restlessness is tired for tonifying the lung pathogenic fire reducing, born fluid.Empty and have fiery person suitable." the present invention adopted modern preparation technique to two the flavor medicinal ingredients make with extra care, the buccal tablet that is prepared from has significant health-care effect.

Summary of the invention the objective of the invention is to set up a kind of preparation method of new buccal tablet,, tobacco and wine weak applicable to body void with its health food that is prepared from excessively, fatigue, brain overwork, human body discomfort, mid-aged population lower for the resistance, the ordinary people that also suits carries out nourishing healthy.

Technical scheme of the present invention is: a kind of buccal tablet, mainly form by Radix Panacis Quinquefolii, Herba Dendrobii and adjuvant.Wherein adjuvant can be: sucrose, lactose, starch, hydroxypropyl emthylcellulose etc.Its preparation method is:

(1) get Herba Dendrobii, add 10 times of water gagings and decoct 3 times, collects 3 times the gained supernatant, filter, concentrated put cold, standby.

(2) get Radix Panacis Quinquefolii, add ethanol mixing pulping, airtight, fully behind the about 2-6h of moistening, place the percolation jar, add ethanol and place more than the 24-48h, the beginning percolation.Reclaim ethanol to there not being the alcohol flavor, concentrate, standby.

(3) add 10 times of water gagings and decoct residue obtained behind the Radix Panacis Quinquefolii percolation, gained supernatant concentration to 1: 1 (g/ml) adds 2-4 and doubly measures ethanol, leaves standstill 24-36h.Gained precipitation adds the purified water dissolving, concentrate put cold, standby.

(4) gained reserve liquid in (1), (2), (3) is condensed into extractum after mixing, standby.

(5) add adjuvant in the extractum, granulate.The gained granule sieves, granulate.Add the magnesium stearate of 1-8%, spray into an amount of Mentholum, mixing, tabletting, coating, promptly.

Wherein, the decoction described in the step (1) decocts 2-8h for the first time, and the back decocts 1-4h twice.

The pH value of water is 3-6 described in the step (1).。

Percolation described in the step (2), flow velocity should be controlled at 1-5ml/min/kg.

In the step (2), concentration of ethanol is 50-80%.

In the step (2), the amount of solvent is 2-8 a times of medical material amount.

Decoction described in the step (3), number of times are 3 times, decoct 2-8h for the first time, and the back respectively decocts 1-4h twice.

In the step (4), extractum density is 1.12-1.35.

Method of granulating in the step (5) is the spray drying marumerization, and its inlet temperature, leaving air temp and temperature of charge should suit, and the charging frequency is 30-80Hz.

In the step (5), sieve number is the 12-60 order.

Coating material described in the step (5) is the coating material of Opadry or other models.

Compared with prior art, the present invention has adopted new technology, and the material of its preparation can be used for mid-aged population lower for the resistance, and also suitable ordinary people carries out nourishing healthy.

The present invention is further illustrated below in conjunction with a plurality of specific embodiment for the specific embodiment: select for use decocting to boil technology, the main influence of investigating amount of water, decocting time and decoction number of times when extracting.The factor level table:

Table 1: factor level table

Horizontal decocting time (hour) the number of times amount of water

1 1.0 1 8

2 2.0 2 10

3 3.0 3 12

Table 2: orthogonal experiment design table and result

Experiment amount of water decocting time extraction time polysaccharide

1 1 1 1 0.819

2 1 2 2 0.977

3 1 3 3 1.021

4 2 1 2 0.991

5 2 2 3 1.048

6 2 3 1 0.848

7 3 1 3 1.075

8 3 2 1 0.862

9 3 3 2 1.038

Determine final technology according to amount of water, decocting time and decoction number of times.

Amount, percolation speed according to percolation time, solvent are determined final technology:

Table 3

Quantity of solvent/medical material amount percolation speed (ml/min/kg) saponin content

3 1 0.51

3 2 0.55

3 3 0.68

5 1 0.56

5 2 0.59

5 3 0.71

7 1 0.45

7 2 0.52

7 3 0.69

Get extractum, adjuvant is tested in different ratios, seeks best proportioning value.

Table 4

Extractum: sucrose: obtained grain graininess of lactose and grain color

Grain graininess met the requirements in 4: 1: 8, and grain color is better, did not have to stick phenomenon

Granule was thinner in 4: 1: 12, and paler colour does not have and sticks phenomenon

Grain graininess was bigger in 4: 1: 3, and color is darker, and the phenomenon of sticking is arranged

Grain graininess was big in 2: 1: 3, and color is darker, caking on a small quantity occurred

Grain graininess was big in 2: 1: 5, and the phenomenon of sticking is arranged, and caking occurred

Get extractum, experimentize, compare experiment with particulate character and granularity by difference turnover pathogenic wind-warm degree.

Table 5

Inlet temperature leaving air temp character and grain graininess

55 38 character are general, and granule is little,

75 55 character are good, and granule is better.

105 75 character are relatively poor, have and stick

Claims

1, a kind of buccal tablet, its composition are Radix Panacis Quinquefolii, Herba Dendrobii and adjuvant.

2, the adjuvant in the claim 1 can be sucrose, lactose, starch, hydroxypropyl emthylcellulose.

3, the buccal tablet described in the claim 1, its preparation method is:

(1) get Herba Dendrobii, add 10 times of water gagings and decoct 3 times, collects 3 times the gained supernatant, filter, concentrated put cold, standby;

(2) get Radix Panacis Quinquefolii, add ethanol mixing pulping, airtight, fully behind the about 2-6h of moistening, place the percolation jar, the ethanol that adds same concentrations is placed more than the 24-48h, the beginning percolation.Reclaim ethanol to there not being the alcohol flavor, concentrate, standby;

(3) add 10 times of water gagings and decoct residue obtained behind the Radix Panacis Quinquefolii percolation, gained supernatant concentration to 1: 1 (g/ml) adds 2-4 and doubly measures ethanol, leaves standstill 24-36h; Gained precipitation adds the purified water dissolving, concentrate put cold, standby;

(4) gained reserve liquid in (1), (2), (3) is condensed into extractum after mixing, standby;

(5) add adjuvant in the extractum, granulate.The gained granule sieves, granulate; Add the magnesium stearate of 1-8%, spray into an amount of Mentholum, mixing, tabletting, coating, promptly.

4, the decoction described in the step (1) in the claim 3 decocts 2-8h for the first time, and the back decocts 1-4h twice.

5, the water described in the step (1) in the claim 3, its pH value is 3-6.

6, the percolation described in the step (2) in the claim 3, flow velocity should be controlled at the 1-5ml/min/kg crude drug.

7, the ethanol described in the step (2) in the claim 3, its concentration is 50-80%.

8, in the claim 3 in the step (2), alcoholic acid total amount be the medical material amount 2-8 doubly.

9, the decoction described in the step (3) in the claim 3, number of times is 3 times, decocts 2-8h for the first time, the back respectively decocts 1-4h twice.

10, the extractum described in the step (4) in the claim 3, its density is 1.12-1.35.

11, the granulation in the step (5) in the claim 3, its method is the spray drying marumerization.

12, the described granule of step (5) sieves in the claim 3, and its sieve number is the 10-60 order.

13, the spray drying marumerization described in the claim 11, its inlet temperature, leaving air temp and temperature of charge should suit, and the charging frequency is 30-80Hz.

14, the application of institute's buccal tablet in preparation health food and medicine in the claim 1.