CN102716367A - Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet - Google Patents

Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet Download PDF

Info

Publication number
CN102716367A
CN102716367A CN2012102134745A CN201210213474A CN102716367A CN 102716367 A CN102716367 A CN 102716367A CN 2012102134745 A CN2012102134745 A CN 2012102134745A CN 201210213474 A CN201210213474 A CN 201210213474A CN 102716367 A CN102716367 A CN 102716367A
Authority
CN
China
Prior art keywords
herba dendrobii
extractum
extract
buccal tablet
dendrobium candidum
Prior art date
Application number
CN2012102134745A
Other languages
Chinese (zh)
Inventor
袁珂
钱溢江
徐殿宏
姜东青
刘华亮
Original Assignee
浙江满堂花生物科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 浙江满堂花生物科技有限公司 filed Critical 浙江满堂花生物科技有限公司
Priority to CN2012102134745A priority Critical patent/CN102716367A/en
Publication of CN102716367A publication Critical patent/CN102716367A/en

Links

Abstract

The invention relates to a compound dendrobium candidum buccal tablet and a preparation method of the compound dendrobium candidum buccal tablet and aims at reaching the effects that the absorption and utilization efficiency and speed of the dendrobium candidum can be respectively improved and accelerated through the provided buccal tablet, and the provided preparation method has the characteristics that the process is simple, and the operation is convenient. The compound dendrobium candidum buccal tablet and the preparation method have the technical scheme that the compound dendrobium candidum buccal tablet comprises compound dendrobium candidum extract extractum, mannitol, dextrin and magnesium stearate which are mixed according to the weight proportion, and the compound dendrobium candidum extract extractum comprises dendrobium candidum, American ginseng, Chinese wolfberry fruit, rhizoma phragmitis, okra, mulberry and astragalus extracts which are determined according to the weight proportion. The preparation method of the buccal tablet comprises the following manufacture steps that (1) the materials are taken according to the raw material proportion; (2) the American ginseng is subjected to backflow extraction processing to obtain extractum A; (3) the extracted American ginseng medicine slag is mixed with other raw materials, decoction and extraction are carried out, and extractum B is obtained; (4) the extractum A and the extractum B are mixed and are then concentrated, and the compound dendrobium candidum extract extractum is obtained; (5) granulation is carried out; and (6) tabletting is carried out.

Description

A kind of compound recipe Herba Dendrobii buccal tablet and preparation method thereof

Technical field

The present invention relates to a kind of health product, specifically is compound recipe Herba Dendrobii buccal tablet and preparation method thereof.

Background technology

Herba Dendrobii is claimed ferrum bracketplant, Herba hedyotis costatae again, and ferrum is green gains the name because of epidermis is for it.Herba Dendrobii is a wonderful work in the Traditional Chinese Medicine, by common people be regarded as Chinese Herba mesonae chinensis, have the effect of the nourishing the stomach of promoting the production of body fluid, nourishing YIN and clearing away heat, lung moistening kidney tonifying, the strong waist that makes eye bright.Herba Dendrobii is praised highly by ancient Chinese medicine doctor, expert in health preserving, the good medicine that be regarded as yin nourishing void, gets rid of illness.

Modern medicine and pharmacology research shows: the main active ingredient of Herba Dendrobii is dendrobium polysaccharide, dendrobine, trace element and aminoacid etc.; Can significantly improve the immunologic function of human body; Effects such as YIN nourishing, detoxifcation, anticancer, arteriosclerosis, blood vessel dilating, blood pressure lowering, resisting fatigue, radioprotective, slow down aging are arranged; In recent years Herba Dendrobii especially the reputation passeris montani saturati rise, widely spread at home and abroad.The relevant health food that with the Herba Dendrobii is raw material all has certain effect at aspects such as improving immunity, antioxidation, slow down aging and cleaning throat and moistening larynx; Cancer is also had certain auxiliary treatment effect, particularly to the cancer patient in symptoms such as thirsty, dry pharynx of putting, occurring after the chemotherapy and retch, have better curative effect.Along with the quickening of modern life rhythm, the increase of life stress, increasing crowd is in the sub-health state of " but do not have disease unhealthy ".Can regulate the health food of body function and will inevitably bring into play certain effect, become the new fulcrum of food service industry development.

Along with the excavation of Herba Dendrobii effect and the development of modern preparation process; The health product that with the Herba Dendrobii are raw material also begin to come into the market; Form is abundant gradually, except Herba Dendrobii extract, also has plurality kinds of health care article such as Herba Dendrobii beverage, Herba Dendrobii crystalline substance, Herba Dendrobii granule.But the Related product listing of Herba Dendrobii buccal tablet novel form is not arranged as yet.

Summary of the invention

The object of the present invention is to provide a kind of compound recipe Herba Dendrobii buccal tablet, the Herba Dendrobii active matter absorbed efficient and speed to improve.

Another object of the present invention provides a kind of method for preparing of compound recipe Herba Dendrobii buccal tablet, and it is simple, easy to operate that this method should have technology, the characteristics that automaticity is high.

The concrete technical scheme that the present invention adopts is:

A kind of compound recipe Herba Dendrobii buccal tablet comprises by the 10 ~ 30:30 ~ 60:10 ~ blended compound recipe Herba Dendrobii of 30:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 1 ~ 2:1 ~ 2:3.8 ~ 5:3.8 ~ 5:2 ~ 3:2 ~ 3:0 ~ 2 part by weight, the extract of the Radix Astragali.

Said Herba Dendrobii is after directly plucking, through cleaning, go the fresh stem and leaf of Herba Dendrobii of root; Or after plucking, through cleaning, go the Herba Dendrobii dried feed after root and oven dry are handled, its moisture content is less than 10%; The Herba Dendrobii dried feed is of use the fresh stem and leaf of Herba Dendrobii of 1 weight portion with 0.15 weight portion.

A kind of method for preparing of compound recipe Herba Dendrobii buccal tablet, make by following step:

1) preparation compound recipe Herba Dendrobii extract extractum

(1) gets Herba Dendrobii 1 ~ 2 weight portion, Radix Panacis Quinquefolii 1 ~ 2 weight portion, Fructus Lycii 3.8 ~ 5 weight portions, Rhizoma Phragmitis 3.8 ~ 5 weight portions, Abelmoschus esculentus 2 ~ 3 weight portions, Fructus Mori 2 ~ 3 weight portions, the Radix Astragali 0 ~ 2 weight portion; Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali shred to 10-20mm;

(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;

(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 1 ~ 3 time, each water that decocts with 8 ~ 12 times of weight, each 1 ~ 4h; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;

(4) above-mentioned extractum A is mixed with extractum B,, get the compound recipe Herba Dendrobii extract extractum of water content 5% ~ 8% through cryoconcentration, subsequent use;

2) film-making

(1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 1 ~ 3:3 ~ 6:1 ~ 3 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;

(2) tabletting

The granule that obtains mixes by the weight ratio of 50 ~ 100:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

Said reflux, extract, is that Radix Panacis Quinquefolii is inserted 6 ~ 10 weight portions, concentration is reflux, extract, 1 ~ 3 time in 50% ~ 80% the alcohol solvent, extracts 1 ~ 3h at every turn; Merge extractive liquid, will be filtrated behind the sucking filtration at concentrating under reduced pressure below 70 ℃.

The invention has the beneficial effects as follows:

1, compound recipe Herba Dendrobii buccal tablet provided by the invention has buccal and absorbs rapidly the characteristics that bioavailability is high.

2, the compound recipe Herba Dendrobii buccal tablet volume of the present invention's preparation is little, and functional component content is high, and is easy to use and carry.

3, the method for preparing of the present invention's preparation, equipment is simple, and is easy to operate, and working condition is controlled easily, and automaticity is high, and production efficiency is high, and can save great amount of manpower.

The specific embodiment

One, pre-treatment

1) after Herba Dendrobii is plucked from open-air or cultivation base, after cleaning, removing root, directly takes; Perhaps, after open-air or the harvesting of cultivation base, warp cleans, goes the dry-cure of root after bake, and its moisture content is less than 10%.

Dried Herba Dendrobii is of use the fresh stem and leaf of Herba Dendrobii of 1 weight portion with 0.15 weight portion.

The proportioning of the Herba Dendrobii described in the present invention all refers to the part by weight of the fresh stem and leaf of Herba Dendrobii.

2) Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali all should suitably shred (generally shredding to 10-20mm).

3) said Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali are dry product, can directly buy from raw material enterprise, pharmacy or market.

Two, the preparation of compound recipe Herba Dendrobii extract extractum

1) Radix Panacis Quinquefolii being inserted 6 ~ 10 weight portions, concentration is reflux, extract, 1 ~ 3 time in 50% ~ 80% the alcohol solvent, extracts 1 ~ 3h at every turn; Merge extractive liquid,, will filtrate behind the sucking filtration is extractum A at concentrating under reduced pressure below 70 ℃ (recommending to adopt vacuum concentration equipment); The moisture content of this extractum can be confirmed according to concrete needs;

2) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 1 ~ 3 time, each water that decocts with 8 ~ 12 times of weight, each 1 ~ 4h; Merge extractive liquid, then, will filtrate at concentrating under reduced pressure below 70 ℃ behind the sucking filtration is extractum B; The moisture content of this extractum also can be confirmed according to concrete needs;

3) above-mentioned extractum A is mixed with extractum B, (evaporating temperature is 25-50 ℃ usually through low-temperature evaporation; Recommend to adopt the low-temperature cooling water circulator bath), get compound recipe Herba Dendrobii extract extractum (water content 5% ~ 8%), subsequent use;

Three, film-making

1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 1 ~ 3:3 ~ 6:1 ~ 3 granulate, oven drying at low temperature (being no more than 50 ℃ usually) obtains water content and is lower than 5% granule;

2) tabletting

The granule that obtains mixes by the weight ratio of 50 ~ 100:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

The present invention except that have clearly indicate, described ratio is weight ratio.

Four, the film-making process data is selected

1, Radix Panacis Quinquefolii extracts solvent

In order to select suitable solvent to extract, select for use 50% ethanol, 70% ethanol, three kinds of different solvents of 95% ethanol to carry out reflux, extract, respectively.Raw material is all got exsiccant Radix Panacis Quinquefolii decoction pieces 20.00g, and solvent load is 200mL, and extraction time is 3h.Respectively the extracting solution vacuum concentration is pumped into dry powder after a certain amount of, weighs, calculated yield is carried out assay simultaneously, and the result sees table 1.

Table 1 different solvents extracts the comparison of extract obtained amount and ratio

Find out that by table 1 along with the increase extract yield increase of concentration of alcohol, and the content of 70% ethanol extraction Radix Ginseng total saponins is higher, takes all factors into consideration, and extracts solvent and preferably selects 70% ethanol.

2, Radix Panacis Quinquefolii method for distilling

With 70% ethanol is solvent, selects merceration extraction, percolation extraction, reflux, extract,, four kinds of methods of supersound extraction for use, is index with the content of extract yield and Radix Ginseng total saponins, preferred method for distilling.

(1) merceration extracts and takes by weighing Radix Panacis Quinquefolii decoction pieces 20.00g, adds to carry 8h with 10 times of amount 70% ethanol mercerations after 70% ethanol makes medical material moistening swelling on a small quantity at every turn, carries altogether 3 times.Merge lixiviating solution, sucking filtration.The vacuum film of will filtrating is concentrated into a certain amount of, and vacuum is pumped into dry powder, weighs, and calculated yield is carried out assay simultaneously, and the result sees table 2.

(2) percolation extracts and takes by weighing Radix Panacis Quinquefolii decoction pieces 20.00g, and in the percolation post of packing into after the 70% ethanol moistening, solubilizer begins percolation after soaking 24h.Control flow velocity 3mL/min collects percolate 600mL.The percolate rotary evaporation is concentrated into to a certain amount of, and vacuum is pumped into dry powder, weighs, and calculated yield is carried out assay simultaneously, and the result sees table 2.

(3) reflux, extract, takes by weighing Radix Panacis Quinquefolii decoction pieces 20.00g, at first with reflux, extract, 3 times behind 10 times of amount 70% soak with ethanol 2h, each 2h.Merge extractive liquid,, the vacuum film of will filtrating behind the sucking filtration is concentrated into a certain amount of, and vacuum is pumped into dry powder, weighs, and calculated yield is carried out assay simultaneously, and the result sees table 2.

(4) supersound extraction takes by weighing Radix Panacis Quinquefolii decoction pieces 20.00g, puts in the ultrasonic extraction device room temperature supersound extraction 3 times with 10 times of amount 70% ethanol, each 30min.Merge extractive liquid,, the vacuum film of will filtrating behind the sucking filtration is concentrated into a certain amount of, and sky is pumped into dry powder, weighs, and calculated yield is carried out assay simultaneously, and the result sees table 2.

The comparison of extract obtained amount of table 2 Different Extraction Method and ratio

Can find out from table 2, adopt four kinds of different method for distilling to extract, the order of extract obtained yield height is: circumfluence method>supercritical ultrasonics technology>cold-maceration>percolation; It can also be seen that from table 2 the content height order of Radix Ginseng total saponins was during Different Extraction Method was extract obtained: reflux>ultrasonic merceration diafiltration.。Therefore method for distilling is selected reflux extraction.

3, Radix Panacis Quinquefolii optimum extraction process

With 70% edible ethanol is solvent, selects the hot reflux method for distilling, selects L for use 9(3 4) orthogonal scheme, select three levels with solvent load, extraction time, three factors of extraction time, each factor, through 3 4Orthogonal experiment is investigated, preferred optimum extraction process.With ginsenoside Re's reference substance serves as to investigate index, and through the content of Radix Ginseng total saponins in the determined by ultraviolet spectrophotometry extract, to optimize optimum extraction process, the result sees table 3, table 4, table 5.

Table 3 factor level table

Table 4 orthogonal experiment plan is taken into account experimental data

Table 5 analysis of variance table

Data are analyzed from the DPS statistical software, F value=mean square/error.Shown by table 4, table 5 range analysis table: each factor effect primary and secondary is B>C>A, but there are no significant for three factors, can know A by experimental result 1B 3C 3Be preferred plan.And in order to save solvent and extraction time, thereby practice thrift cost, then A 1B 2C 2Be optimal case.Promptly use 8 times of amount 70% ethanol to extract 2 times each 2h. as solvent refluxing

4, the extraction process of compound recipe Herba Dendrobii extract

For the extraction process of preferred 7 kinds of medical materials of water boiling and extraction,, select L for use with the decocting cooking method 9(3 4) orthogonal scheme, water consumption, decocting time, three factors of decoction number of times, each factor are chosen three levels and are carried out the orthogonal experiment investigation, optimize optimised process.With the glucose reference substance serves as to investigate index, and through the content of total polysaccharides in the determined by ultraviolet spectrophotometry extract, to optimize optimum extraction process, the result sees table 6, table 7 and table 8.

Table 6 factor level table

Table 7 orthogonal experiment plan is taken into account experimental data

Table 8 analysis of variance table

By table 7 and table 8 orthogonal table and the explanation of variance table, No. 4 the result of the test total saponin content is higher, and each factor is carried out variance analysis, and the factor affecting size is followed successively by C>B>A, but there are no significant for three factors, and the Comprehensive Experiment result can know A 2B 1C 2Be optimal case.Promptly decoct with 10 times of water gagings at every turn and extract each 2h 2 times.

5, the assay of total polysaccharides in compound recipe Herba Dendrobii extract and the buccal tablet thereof

(1) principle

The polysaccharide that extracts in the sample is through 80% ethanol precipitating; Remove interfering materials such as monosaccharide, oligosaccharide, under the concentrated sulphuric acid effect, be hydrolyzed into the monosaccharide molecule earlier, and dehydration generates the alditol derivant rapidly; Be condensed into colored compound with phenol then, measure its optical density in the 490nm wavelength.With glucose as a standard article are handled standard curve with the sample same procedure, obtain the standard curve regression equation, try to achieve the polyoses content in the sample through calculating.

(2) preparation of instrument and solution

Spectrophotometer; Ether (analytical pure); Dehydrated alcohol (analytical pure).

The glucose titer: precision takes by weighing 105 ℃ of standard glucose 100mg that are dried to constant weight, puts in the 100ml volumetric flask, adds water and makes dissolving in right amount, is diluted to scale, shakes up.The accurate 10ml that draws puts in the 100ml volumetric flask, be diluted with water to scale and.

Phenol test solution: take by weighing phenol 10g, add water to the 150g mixing, dissolving is promptly got.Put in the brown bottle, it is subsequent use to put refrigerator.

(3) preparation of standard curve

Precision is drawn glucose titer 0.0,0.1,0.2,0.3,0.4,0.5,0.6,0.7,0.8ml places tool plug test tube respectively, and each adding distil water makes into 2.0ml, respectively adds phenol test solution 1.0ml again; Shake up, drip concentrated sulphuric acid 5.0ml rapidly, shake up rapidly; Place 5min, boiling water bath is placed 15min, takes out; Be cooled to room temperature, survey its absorbance in the 490nm wavelength, and the drawing standard curve.

(4) processing of sample and mensuration

Accurately take by weighing content 1.5000g in round-bottomed flask, an amount of backflow half an hour that add diethyl ether filtered, and filtering residue volatilizes solvent, with 80% ethanol 100ml reflux, extract, 1h, takes advantage of heat filtering, and medicinal residues wash with 80% hot ethanol.Medicinal residues adding distil water 85ml, backflow 1h takes advantage of heat filtering, with hot distilled water washing, treat to move in the 250ml volumetric flask after cold, with distilled water diluting to scale.The accurate test liquid medicinal residues of drawing are used 0.5ml, and adding distil water makes into 2.0ml, adds phenol solution 1.0ml again, with a standard curve preparation operation down.By the polyoses content of trying to achieve sample in the standard curve.

(5) computing formula:

X=Cs×V×D×100/M。In the formula, X be polyoses content in the sample (with glucose meter) (g/100g), Cs is the concentration of glucose (μ g/ml) of sample solution, D is the dilution factor of sample solution, V is the volume (ml) of sample solution, M is the sampling amount of sample.

Through measuring, the content of total polysaccharides is 6.23% ~ 12.56% in the compound recipe Herba Dendrobii extract, and the content of total polysaccharides is 2.33%~6.04 in the buccal tablet.

6, the assay of total saponins in compound recipe Herba Dendrobii extract extractum and the compound recipe Herba Dendrobii buccal tablet

(1) principle

The total saponins that extracts in the sample shows rufous under vanillin alcoholic solution and effect of sulfuric acid.Measure its optical density in the 545nm wavelength.With ginsenoside Re is standard substance, handles standard curve with the sample same procedure, obtains the standard curve regression equation, tries to achieve the content of total saponins in the sample through calculating.

(2) preparation of instrument and solution

Spectrophotometer; Ether (analytical pure); Methanol (analytical pure); Dehydrated alcohol (analytical pure); 95% ethanol (analytical pure); The D101 macroporous resin.

The preparation of reference substance solution: ginsenoside Re's standard substance 10.0mg that precision takes by weighing 60 ℃ of drying under reduced pressure to constant weights, put in the 10ml volumetric flask, add an amount of methanol and make dissolving, and be diluted to scale, shake up, promptly get.

8% vanillin ethanol solution: take by weighing the 0.8g vanillin, add dehydrated alcohol 10ml and make dissolving.

77% sulfuric acid solution: get 23ml water in beaker, slowly add the 77ml concentrated sulphuric acid, shake up, cool to room temperature promptly gets.

(3) preparation of standard curve

Accurate reference substance solution 0,30,60,90,120, the 150 μ l that draw place 10ml tool plug test tube respectively, wave most solvent; Accurate 8% vanillin ethanol solution 0.5ml and the 77% sulfuric acid solution 5ml that adds new preparation shakes up, and puts 60 ℃ of heating in water bath 10min; Take out, cool off 10min in the ice bath, take out; Cool off 10min in the water-bath, measure its absorbance in the 545nm wavelength, and the drawing standard curve.

(4) sample treatment and mensuration

Precision takes by weighing content 1.000g, puts in the apparatus,Soxhlet's, adds an amount of ether and takes off ester, waves most solvent, adds methanol 50ml reflux, extract, and is colourless to extracting solution.Extracting solution is put in the evaporating dish, and evaporate to dryness in the water-bath, residue add the low amounts of water dissolving, are transferred in the 10ml measuring bottle, and thin up is to scale.The accurate 2ml that draws adds the D101 macroporous resin chromatographic column of having handled well, and (internal diameter 0.9cm, high 10cm), first water 20ml slowly washs with 0.4~0.5ml/min speed.Discard washing liquid, continue the same speed washing with 70% ethanol 30ml.Collect eluent, evaporate to dryness in the water-bath, residue dissolves with small amount of methanol and is transferred in the 2ml measuring bottle, divides washing container for several times with small amount of methanol, and washing liquid is incorporated measuring bottle into, and methanol is diluted to scale, shakes up.The accurate 50 μ l that draw put in the 10ml tool plug test tube, wave most solvent, with the operation down of standard curve item.Content by the ginseng total saponins of trying to achieve sample in the standard curve.

(5) calculate

X=A×100÷(M×V/2×1/5)。In the formula, X be ginseng total saponins in the sample content (in Re) (g/100g), A for read from standard curve the content (μ g) of ginseng total saponins the sample liquid, V is the volume (ml) of sample solution, M is the sampling amount of sample.Through measuring, the content of total saponins is 0.85%~2.58% in the compound recipe Herba Dendrobii extract, and the content of total saponins is 0.23%~1.45 in the buccal tablet.

Embodiment 1

A kind of compound recipe Herba Dendrobii buccal tablet comprises by the blended compound recipe Herba Dendrobii of 10:30:10:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 1:1:3.8:3.8:2:2:0.5 part by weight, the extract of the Radix Astragali.

Said Herba Dendrobii is after directly plucking, through cleaning, go the fresh stem and leaf of Herba Dendrobii of root.

Manufacturing process is:

1) preparation compound recipe Herba Dendrobii extract extractum

(1) shreds Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali to 10-20mm earlier;

(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;

(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 2 times, each water that decocts with 8 times of weight, 2h at every turn; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;

(4) above-mentioned extractum A is mixed with extractum B,, get compound recipe Herba Dendrobii extract extractum through low-temperature evaporation, water content 8%, subsequent use;

2) film-making

(1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 1:3:1 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;

(2) tabletting

The granule that obtains mixes by the weight ratio of 50:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

Embodiment 2

A kind of compound recipe Herba Dendrobii buccal tablet comprises by the blended compound recipe Herba Dendrobii of 20:40:20:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 2:2:5:5:3:3:2 part by weight, the extract of the Radix Astragali.

Said Herba Dendrobii is after plucking, and through cleaning, go the Herba Dendrobii dried feed after root and oven dry are handled, its moisture content is less than 10%; The Herba Dendrobii dried feed is of use the fresh stem and leaf of Herba Dendrobii of 1 weight portion with 0.15 weight portion.

Manufacturing process is:

1) preparation compound recipe Herba Dendrobii extract extractum

(1) shreds Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali to 10-20mm earlier;

(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;

(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 3 times, each water that decocts with 12 times of weight, 4h at every turn; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;

(4) above-mentioned extractum A is mixed with extractum B,, get compound recipe Herba Dendrobii extract extractum through low-temperature evaporation, water content 7%, subsequent use;

2) film-making

(1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 2:4:3 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;

(2) tabletting

The granule that obtains mixes by the weight ratio of 100:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

Embodiment 3

A kind of compound recipe Herba Dendrobii buccal tablet comprises by the blended compound recipe Herba Dendrobii of 30:60:30:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 1.5:1.5:4.5:4.5:2.5:2.5:1 part by weight, the extract of the Radix Astragali.

Said Herba Dendrobii is after directly plucking, through cleaning, go the fresh stem and leaf of Herba Dendrobii of root.

Manufacturing process is:

1) preparation compound recipe Herba Dendrobii extract extractum

(1) shreds Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali to 10-20mm earlier;

(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;

(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 2, each water that decocts with 10 times of weight, 3h at every turn; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;

(4) above-mentioned extractum A is mixed with extractum B, adopt low-temperature cooling water circulator bath low-temperature evaporation, get compound recipe Herba Dendrobii extract extractum, water content 6%, subsequent use;

2) film-making

(1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 1.5:4:1.5 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;

(2) tabletting

The granule that obtains mixes by the weight ratio of 60:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

Embodiment 4

A kind of compound recipe Herba Dendrobii buccal tablet comprises by the blended compound recipe Herba Dendrobii of 15:45:15:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 1.2:1.2:4:4:2.3:2.3:0.8 part by weight, the extract of the Radix Astragali.

Said Herba Dendrobii is after plucking, and through cleaning, go the Herba Dendrobii dried feed after root and oven dry are handled, its moisture content is less than 10%; The Herba Dendrobii dried feed is of use the fresh stem and leaf of Herba Dendrobii of 1 weight portion with 0.15 weight portion.

Manufacturing process is:

1) preparation compound recipe Herba Dendrobii extract extractum

(1) shreds Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali to 10-20mm earlier;

(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;

(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 1 ~ 3 time, decoct at every turn, each 3.5h with 9 times of water gagings; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;

(4) above-mentioned extractum A is mixed with extractum B, adopt low-temperature cooling water circulator bath low-temperature evaporation, get compound recipe Herba Dendrobii extract extractum, water content 7%, subsequent use;

2) film-making

(1) granulates

Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 2:3:3 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;

(2) tabletting

The granule that obtains mixes by the weight ratio of 50:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.

Claims (4)

1. a compound recipe Herba Dendrobii buccal tablet comprises by the 10 ~ 30:30 ~ 60:10 ~ blended compound recipe Herba Dendrobii of 30:1 part by weight extract extractum, mannitol, dextrin and magnesium stearate; Said compound recipe Herba Dendrobii extract extractum contains Herba Dendrobii, Radix Panacis Quinquefolii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, the Fructus Mori of 1 ~ 2:1 ~ 2:3.8 ~ 5:3.8 ~ 5:2 ~ 3:2 ~ 3:0 ~ 2 part by weight, the extract of the Radix Astragali.
2. a kind of compound recipe Herba Dendrobii buccal tablet according to claim 1 is characterized in that said Herba Dendrobii is after directly plucking, through cleaning, go the fresh stem and leaf of Herba Dendrobii of root; Or after plucking, through cleaning, go the Herba Dendrobii dried feed after root and oven dry are handled, its moisture content is less than 10%; The Herba Dendrobii dried feed is of use the fresh stem and leaf of Herba Dendrobii of 1 weight portion with 0.15 weight portion.
3. the method for preparing of a compound recipe Herba Dendrobii buccal tablet, make by following step:
1) preparation compound recipe Herba Dendrobii extract extractum
(1) gets Herba Dendrobii 1 ~ 2 weight portion, Radix Panacis Quinquefolii 1 ~ 2 weight portion, Fructus Lycii 3.8 ~ 5 weight portions, Rhizoma Phragmitis 3.8 ~ 5 weight portions, Abelmoschus esculentus 2 ~ 3 weight portions, Fructus Mori 2 ~ 3 weight portions, the Radix Astragali 0 ~ 2 weight portion; Herba Dendrobii, Rhizoma Phragmitis, Radix Panacis Quinquefolii, the Radix Astragali shred to 10-20mm;
(2) the Radix Panacis Quinquefolii reflux, extract, is handled, obtained extractum A;
(3) medicinal residues after the Radix Panacis Quinquefolii extraction are mixed decoction with Herba Dendrobii, Fructus Lycii, Rhizoma Phragmitis, Abelmoschus esculentus, Fructus Mori, the Radix Astragali and extract 1 ~ 3 time, each water that decocts with 8 ~ 12 times of weight, each 1 ~ 4h; Merge extractive liquid, will be filtrated behind the sucking filtration at the acquisition of concentrating under reduced pressure below 70 ℃ extractum B then;
(4) above-mentioned extractum A is mixed with extractum B,, get water content 5% ~ 8% Hu Fufang Herba Dendrobii extract extractum through low-temperature evaporation, subsequent use;
2) film-making
(1) granulates
Compound recipe Herba Dendrobii extract extractum is mixed the back with mannitol, dextrin by the weight ratio of 1 ~ 3:3 ~ 6:1 ~ 3 granulate, oven drying at low temperature obtains water content and is lower than 5% granule;
(2) tabletting
The granule that obtains mixes by the weight ratio of 50 ~ 100:1 with magnesium stearate, and it is an amount of then to get Mentholum, and the dissolve with ethanol with 95% evenly is sprayed on the granule; Carry out tabletting, plastic-aluminum pressing plate, packing then, obtain finished product.
4. the method for preparing of a kind of compound recipe Herba Dendrobii buccal tablet according to claim 3 is characterized in that said reflux, extract, is that Radix Panacis Quinquefolii is inserted 6 ~ 10 weight portions, concentration is reflux, extract, 1 ~ 3 time in 50% ~ 80% the alcohol solvent, extracts 1 ~ 3h at every turn; Merge extractive liquid, will be filtrated behind the sucking filtration at concentrating under reduced pressure below 70 ℃.
CN2012102134745A 2012-06-21 2012-06-21 Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet CN102716367A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2012102134745A CN102716367A (en) 2012-06-21 2012-06-21 Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2012102134745A CN102716367A (en) 2012-06-21 2012-06-21 Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet

Publications (1)

Publication Number Publication Date
CN102716367A true CN102716367A (en) 2012-10-10

Family

ID=46942321

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012102134745A CN102716367A (en) 2012-06-21 2012-06-21 Compound dendrobium candidum buccal tablet and preparation method of compound dendrobium candidum buccal tablet

Country Status (1)

Country Link
CN (1) CN102716367A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102949597A (en) * 2012-11-01 2013-03-06 上海中海龙高新技术研究院 Pure dendrobium officinale kimura et migo buccal tablets and preparation method thereof
CN102987406A (en) * 2012-11-02 2013-03-27 西华大学 Okra healthcare buccal tablets and preparation method thereof
CN103262974A (en) * 2013-06-03 2013-08-28 浙江中赢方舟生物工程股份有限公司 Medlar polysaccharide chewable tablet and preparation method thereof
CN103749829A (en) * 2014-01-14 2014-04-30 桂林丰润莱生物科技有限公司 Dendrobium officinale health-care tea and preparation method thereof
CN104431165A (en) * 2014-11-24 2015-03-25 福建省科奥生物技术研发中心有限公司 Dendrobium officinale healthcare health-preserving tea as well as preparation method and application thereof
CN104605343A (en) * 2014-12-31 2015-05-13 台州康晶生物科技有限公司 Dendrobium candidum buccal tablets and preparation method thereof
CN104771594A (en) * 2015-03-12 2015-07-15 霍山县茗雨商贸有限公司 Dendrobium manufacturing method
CN105029394A (en) * 2014-04-15 2015-11-11 四川万安石斛产业开发有限公司 Anti-fatigue health-caring product or medicine composition
CN105497568A (en) * 2016-02-18 2016-04-20 云南久丽康源石斛开发有限公司 Dendrobium officinale lozenge with throat curing function and preparing method thereof
CN106309735A (en) * 2016-10-26 2017-01-11 哈药集团三精制药有限公司 Preparation method of American ginseng pollen oral liquid
CN106983827A (en) * 2017-06-01 2017-07-28 广德美处电子商务有限公司 A kind of compound buccal lozenge with stomach invigorating effect

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692216A (en) * 1979-12-27 1981-07-25 Sunstar Inc Peripheral circulation improver containing crude drug
JPH10127256A (en) * 1996-10-30 1998-05-19 Makoto Kawazoe Preservative tea for diabetes and its production
CN1640439A (en) * 2004-01-09 2005-07-20 浙江大德药业集团有限公司 Method for preparing oral tablet
CN102132872A (en) * 2011-03-04 2011-07-27 浙江农林大学 Health care food and application thereof
CN102370173A (en) * 2011-10-10 2012-03-14 四川蓝田生物科技有限公司 Okra healthcare food
CN102415568A (en) * 2011-12-13 2012-04-18 常熟雷允上制药有限公司 Health food for improving immunity and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5692216A (en) * 1979-12-27 1981-07-25 Sunstar Inc Peripheral circulation improver containing crude drug
JPH10127256A (en) * 1996-10-30 1998-05-19 Makoto Kawazoe Preservative tea for diabetes and its production
CN1640439A (en) * 2004-01-09 2005-07-20 浙江大德药业集团有限公司 Method for preparing oral tablet
CN102132872A (en) * 2011-03-04 2011-07-27 浙江农林大学 Health care food and application thereof
CN102370173A (en) * 2011-10-10 2012-03-14 四川蓝田生物科技有限公司 Okra healthcare food
CN102415568A (en) * 2011-12-13 2012-04-18 常熟雷允上制药有限公司 Health food for improving immunity and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
不详: "中医护眼招", 《健康时报》, 1 March 2013 (2013-03-01), pages 08 - 1 *
杭州天目商贸有限公司: "铁皮石斛软胶囊", 《HTTP://WWW.88LAN.COM/ZHAOSHANG/D/?ID=23146.HTML》, 11 April 2008 (2008-04-11) *
蔡光先等: "铁皮石斛古代与现代的应用概况", 《湖南中医药大学学报》, vol. 31, no. 5, 31 May 2011 (2011-05-31) *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102949597A (en) * 2012-11-01 2013-03-06 上海中海龙高新技术研究院 Pure dendrobium officinale kimura et migo buccal tablets and preparation method thereof
CN102987406A (en) * 2012-11-02 2013-03-27 西华大学 Okra healthcare buccal tablets and preparation method thereof
CN103262974A (en) * 2013-06-03 2013-08-28 浙江中赢方舟生物工程股份有限公司 Medlar polysaccharide chewable tablet and preparation method thereof
CN103262974B (en) * 2013-06-03 2015-07-29 杭州中赢科技集团有限公司 A kind of medlar polysaccharide chewable tablet and preparation method thereof
CN103749829A (en) * 2014-01-14 2014-04-30 桂林丰润莱生物科技有限公司 Dendrobium officinale health-care tea and preparation method thereof
CN103749829B (en) * 2014-01-14 2015-08-12 桂林丰润莱生物科技有限公司 Dendrobium candidum health-care tea and preparation method
CN105029394A (en) * 2014-04-15 2015-11-11 四川万安石斛产业开发有限公司 Anti-fatigue health-caring product or medicine composition
CN104431165A (en) * 2014-11-24 2015-03-25 福建省科奥生物技术研发中心有限公司 Dendrobium officinale healthcare health-preserving tea as well as preparation method and application thereof
CN104605343A (en) * 2014-12-31 2015-05-13 台州康晶生物科技有限公司 Dendrobium candidum buccal tablets and preparation method thereof
CN104605343B (en) * 2014-12-31 2016-05-18 台州康晶生物科技有限公司 Dendrobium candidum lozenge and preparation method thereof
CN104771594A (en) * 2015-03-12 2015-07-15 霍山县茗雨商贸有限公司 Dendrobium manufacturing method
CN105497568A (en) * 2016-02-18 2016-04-20 云南久丽康源石斛开发有限公司 Dendrobium officinale lozenge with throat curing function and preparing method thereof
CN106309735A (en) * 2016-10-26 2017-01-11 哈药集团三精制药有限公司 Preparation method of American ginseng pollen oral liquid
CN106309735B (en) * 2016-10-26 2019-01-18 哈药集团三精制药有限公司 The preparation method of American ginseng-pollen oral solution
CN106983827A (en) * 2017-06-01 2017-07-28 广德美处电子商务有限公司 A kind of compound buccal lozenge with stomach invigorating effect

Similar Documents

Publication Publication Date Title
CN100391495C (en) Process for extracting litchi polyphenol from litchi
CN102988827B (en) Dendrobium officinale granula
Tang et al. Dendrobium officinale Kimura et Migo: a review on its ethnopharmacology, phytochemistry, pharmacology, and industrialization
CN102988828B (en) Preparation method of dendrobium officinale granula
CN102771868A (en) Dendrobium candidum solution
CN108186690A (en) A kind of Chinese medicine processing method
CN102119992B (en) Pharmaceutical preparation prepared from fresh motherwort and fresh aloe and preparation method thereof
CN103585400B (en) Have and strengthen immunologic function and the compositions alleviating fatigue effect and preparation method thereof
CN103451022B (en) Method for integrally extracting volatile oil, polysaccharide and flavone from elsholtzia haichowensis sun
CN102391385B (en) Extraction and purification method of bioactive polysaccharides in dendrobium huoshanense
CN102928373B (en) Method for testing content of dendrobe polysaccharide and application thereof
CN104856968B (en) A kind of Chinese medicinal tablet with eliminating thrombus and removing obstruction in channels effect and preparation method thereof
CN101829138B (en) Composition for strengthening immune regulation function in human body and applications thereof
CN102319364A (en) Manufacturing method of dendrobium candidum wallex lindll pure powder tablets
CN103300132B (en) Method for manufacturing Chinese date pieces by utilizing medium short wave infra-red drying method
CN102146142B (en) Method for preparing astragalus polysaccharides
CN103141832B (en) Black fungus dietary therapy health maintenance food and preparation method thereof
CN103860631A (en) Method for preparing liquorice active substances
CN1631904A (en) Process for extracting polysaccharide from astragalus root
CN103142669B (en) Enzyme method for extracting ginsenoside and obtained ginsenoside extractive
CN106083946B (en) A kind of process for extracting tannin from dye yam
CN103159864A (en) Separation and purification method of lycium ruthenicum polysaccharide and five polysaccharides obtained through separation
CN102526315B (en) Preparation method of extracts of effective fractions of lychee seeds
CN103776926B (en) The foundation of rabdosia lophanthide HPLC-FPS
CN102973870A (en) Decanting chewable tablet and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
C06 Publication
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121010

C02 Deemed withdrawal of patent application after publication (patent law 2001)