CN1820773A - Chinese medicine composition for treating oral inflammation and its preparation - Google Patents

Abstract

The present invention discloses a kind of Chinese medicine composition for treating acute and chronic pharyngitis, laryngitis, stomatitis and oral ulcer. The Chinese medicine composition is prepared with nine kinds of Chinese medicinal materials, including pearl powder, figwort, phellodendron bark, natural indigo, gallnut, etc. It has obvious curative effect, few toxic side effect and convenient use. It has the functions of nourishing Yin, eliminating fire, promoting the secretion of saliva, cooling blood, detoxicating, etc.

Description

A kind of Chinese medicine composition and preparation thereof for the treatment of oral inflammation

Technical field

The invention belongs to the medicine of treatment otorhinolaryngology disease, especially treat the Chinese medicine composition and the preparation thereof of acute/chronic pharyngitis, laryngitis, stomatitis, oral ulcer.

Background technology

Acute/chronic pharyngitis, laryngitis, stomatitis, oral ulcer etc. are modal diseases in pharynx, larynx, the position, oral cavity.Common sympton has affected part congestion and swelling pain or erosion, the scorching hot or itching throat and dry cough of dry pharynx, and throat blocks, hoarseness.Produce disease and these symptoms, except that local antibacterial, viral infection, also stimulate as dry, harmful gas with external condition, the internal metabolism obstacle that excessive tobacco and wine and Chronic consumptions cause is relevant with degradation factor under the resistance.

Motherland's medical science thinks, the evil poison infringement of exopathogenic factor six climate exopathogens, and endogenous cause of ill feelings will internal injury, gas fire stagnation knot, or process rich, pungent product and give birth in the fire-toxin because of surfeit alcohol spills, or the excess of YANG of the plain body deficiency of YIN, following on the fire-toxin, hyperactivity of deficient fire is all tied in throat.So should be in the treatment with the nourishing YIN pathogenic fire reducing Zhi Qiben that promotes the production of body fluid, the removing pathogenic heat from blood and toxic substance from the body sore-throat relieving is controlled its mark.

Throat is that department's diet, row are breathed, soniferous organ, on connect the oral cavity, following logical lung stomach is again the communications centre of running course of channel.Wind-heat evil toxin is invaded outward, from outward appearance to inner essence, enemy intrusion or invasion's lung stomach, then pathogenic heat are accumulate long-pendingly, follow through last inflammation, burn in pharyngeal and send out and be acute pharyngitis due to wind-heat (being equivalent to the acute pharyngolaryngitis in the modern medicine).If strain body void, lung deficiency of the kidney consumption, YIN fluid being insufficient, asthenic fire follow through, on steam pharyngeally, then satisfy into hypopyretic laryngalgia (being equivalent to the chronic pharyngitis in the modern medicine).For above treatment of diseases, motherland's medical science is emphasized should be based on clear pathogenic heat, resolving toxin and disinhibiting the throat, the YIN nourishing and the production of body fluid promoting of dredging.

Acute pharyngitis due to wind-heat (being equivalent to the acute pharyngolaryngitis in the modern medicine) mainly shows as: onset is anxious, the course of disease is short, the patient has pharyngalgia, dysphagia, dryness and heat, performances such as thirsty heating, the visible pharyngeal hyperemia redness of toposcopy is disliked and is stopped up the redness of hanging down, pharynx rear wall follicle hypertrophy, or see oral cavity, pharyngolaryngeal mucosa ulcerate disease, red tip of the tongue, yellow and thin fur or thin fur, wiry and frequent pulse.

Hypopyretic laryngalgia (being equivalent to the chronic pharyngolaryngitis in the modern medicine), mainly show as: patient's course of disease is long, and onset is slow, and pharyngalgia history is repeatedly arranged; Conscious dry pharynx pain, scorching hot, then aggravation of many speeches has dry cough sometimes, foreign body sensation, happiness drinking-water, but still feel dry, and to check and see that pharyngeal mucosa is kermesinus, mucosa drying or atrophy can have follicle hypertrophy sometimes, and the red tongue tongue is few, or slight crack is arranged, wiry and frequent pulse.

Adopt western medicine acute/chronic pharyngitis, laryngitis, stomatitis, all diseases of oral ulcer, clinical practice is more just like medicines such as penicillins, sulfonamides, adrenocortical hormoness, though curative effect can, side effect is bigger, use inconvenience, the patient usually does something against one's will.

The application of Chinese medicine preparation also begins, and in recent years, constantly has new drug to come out.Representative and Chinese medicine that gone on the market has GUILIN XIGUA SHUANG, and the key component of said preparation is: Cortex Phellodendri, Indigo Naturalis, Borneolum Syntheticum, Mentholum, watermelon crystal, Borax (forging), Radix Scutellariae, Rhizoma Coptidis, Radix Sophorae Tonkinensis, Bulbus Fritillariae Thunbergii, Rhizoma Belamcandae, Fructus Sapindi Mukouossi fruit (charcoal); Adjuvant is: silicon dioxide, steviosin, citric acid.Though also be Chinese medicine preparation, said preparation still contain part Western medicine adjuvant component and effect also not ideal.

The inventor is on existing treatment acute/chronic pharyngitis, laryngitis, the empirical basis of oral ulcer, and in conjunction with modern medicine and pharmacology, screening meticulously obtains to optimize proportioning, be developed further into powder, tablet, liquor, gel, membrane preparation series.Preparation series of the present invention is easy to use, is easy to carry about with one, and is evident in efficacy, and has no pain, non-invasive, characteristics that toxic and side effects is little.

Summary of the invention

The present invention aims to provide a kind of pure Chinese medicine composition for the treatment of acute/chronic pharyngitis, laryngitis, stomatitis, oral ulcer, said composition preparation curative effect is more remarkable, performance is better, and its component is: Margarita powder, Radix Scrophulariae, Cortex Phellodendri, Indigo Naturalis, Galla Chinensis, Alumen (forging), Radix Glycyrrhizae, Mentholum, Borneolum Syntheticum.

According to Golden Mirror of Medicine " BINGPENG SAN ", the compatibility principle and the clinical practice of nourishing yin shengjisan are made in the XILEI SAN in " the golden deficient wing " and " the yellow crown group side ", have wherein reused the Margarita component.

The present invention treats the Chinese medicine composition and the preparation thereof of oral inflammation, it is characterized in that raw material components and weight proportion that its compositions or preparation contain are:

Margarita powder 320～480 gram Radix Scrophulariaes 64～96 gram Cortex Phellodendris 64～96 grams

Indigo Naturalis 128～192 gram Galla Chinensiss 128～192 gram Alumens (forging) 32～48 grams

Radix Glycyrrhizae 96～144 gram Mentholums 32～48 gram Borneolum Syntheticums 96～144 grams.

The Chinese medicine composition of described treatment oral inflammation and preparation thereof is characterized in that the raw material components optimum weight proportioning that its compositions or preparation contain is:

Margarita powder 400 gram Radix Scrophulariaes 80 gram Cortex Phellodendris 80 grams

Indigo Naturalis 160 gram Galla Chinensiss 160 gram Alumens (forging) 40 grams

Radix Glycyrrhizae 120 gram Mentholums 40 gram Borneolum Syntheticums 120 grams.

The main Margarita powder of using of the present invention with Radix Scrophulariae, Cortex Phellodendri, Indigo Naturalis, Galla Chinensis, Alumen (forging) Radix Glycyrrhizae, Mentholum, Borneolum Syntheticum compatibility, has been given prominence to the mastery reaction of Margarita powder.It is collaborative that each efficacy of drugs is produced, thereby can treat the inflammation disease of acute/chronic pharyngitis, laryngitis, stomatitis, oral ulcer effectively.And be made for powder, tablet, liquor, gel and membrane preparation for selecting for use, preparation of the present invention is Hangzhou Chinese Medicinal Hospital's department of otorhinolaryngology, Hangzhou Chinese Medicinal Hospital, the clinical verification of Zhejiang College Of Traditional Chinese Medicine out-patient department, acute/chronic pharyngitis, laryngitis, stomatitis, oral ulcer are all had obvious curative effects, and total effective rate reaches 87.5%.The present composition has the effect of nourishing YIN pathogenic fire reducing, secretion replenishing and throat moistening, removing pathogenic heat from blood and toxic substance from the body, putrefaction-removing granulation-promoting, reducing swelling and alleviating pain, acute and chronic pharyngitis, stomatitis, oral ulcer is had well test effect.

The specific embodiment

The component of the present composition is: Margarita powder, Radix Scrophulariae, Cortex Phellodendri, Indigo Naturalis, Galla Chinensis, Alumen (forging), Radix Glycyrrhizae, Mentholum, Borneolum Syntheticum.Wherein

In the present composition main separation reuse flavor---the sweet cold Margarita powder of property, removing toxic substances and promoting granulation, heat clearing away putrefaction removing, relieving sore throat and diminishing swelling, " book on Chinese herbal medicine converge speech " are called it can " poison that unhitches, change malignant boil, receive the internal ulceration junk ".Indigo Naturalis is salty and cold in nature, walks blood and closes, and is the good merchantable brand of heat clearing away blood detoxifcation, and " book on Chinese herbal medicine newly organized " claims that this medicine can " red swollen treatments that disappear be malicious, the excess-fire sore throat ".Reusing above two medicines in the side, is monarch drug altogether.Radix Scrophulariae is salty-cold product, and matter is moistened many liquid, and " product converge with essence will " say its " clearing throat is swollen, rushes down the fire of unrooted ", and " book on Chinese herbal medicine justice " points out that then it " treats pharyngalgia of wind heat ", so medicine can lung-heat clearing and detoxification, but again nourishing YIN to lower pathogenic fire with throat; The Cortex Phellodendri bitter cold, the merit of clearing away heat-fire detoxifcation is rather good, and the kind kidney fire that rushes down; Gallic acid, puckery, cold in nature, Compendium of Material Medica are called its " detumescence poison, sore throat, hold back routed skin ulcer ", having detoxifcation to hold back the effect of skin ulcer.More than three medicines, be ministerial drug altogether, both principal drug assistance purging fire and cooling blood detoxifcations, and can hold back skin ulcer by secretion replenishing and throat moistening.Be equipped with suffering, hardship in the side and cool Borneolum Syntheticum, the hot fragrance that looses, in reach internal organs, logical outward nine orifices has clearing heat for detumescence, the power of pain relieving granulation promoting, " medical center bun will " be said its " the main stagnated fire of loosing ", controlled " sore throat, swelling of the tongue, toothache "; Dried Alumen acid, puckery and cold, the detoxifcation of removing heat-phlegm, dampness, " Elementary Medicine " points out that this medicine " controls aphtha of the mouth and tongue ", controls " acute pyogenic infection of the pharynx numbness "; Herba Menthae is hot cool, and suffering can be dispersed, but the cold heat clearing away, body is gently up, and the saturating key of fragrance is good at clearing throat, so Compendium of Material Medica claims its " throat is nibbled all diseases ".More than three medicines be all adjuvant drug.Make in the side with sweet flat Radix Glycyrrhizae, can eliminating fire and detoxication with throat, can relax the property of medicine again, during stomach function regulating is transferred.All medicine compatibilities are played the merit of removing pathogenic heat from blood and toxic substance from the body, secretion replenishing and throat moistening, putrefaction removing detumescence altogether, make that wind heat disappears, clear, the cloudy Tianjin of evil poison is multiple, and then all diseases of bottleneck throat are all removed.

Above-mentioned standard of respectively distinguishing the flavor of crude drug comes from the Pharmacopoeia of the People's Republic of China 2005 editions.

1, Margarita powder: press 2005 editions one one the 159th page of the Pharmacopoeia of the People's Republic of China.

2, Radix Scrophulariae: press 2005 editions one one the 76th page of the Pharmacopoeia of the People's Republic of China.

3, Cortex Phellodendri: press 2005 editions one one the 214th page of the Pharmacopoeia of the People's Republic of China.

4, Indigo Naturalis: press 2005 editions one one the 138th page of the Pharmacopoeia of the People's Republic of China.

5, Galla Chinensis: press 2005 editions one one the 45th page of the Pharmacopoeia of the People's Republic of China.

6, Alumen (forging): press 2005 editions one one the 70th page of the Pharmacopoeia of the People's Republic of China.

7, Radix Glycyrrhizae: press the 59th page of 2005 editions two appendix of the Pharmacopoeia of the People's Republic of China.

8, Mentholum: press 2005 editions one one the 261st page of the Pharmacopoeia of the People's Republic of China.

9, Borneolum Syntheticum: press 2005 editions one one the 98th page of the Pharmacopoeia of the People's Republic of China.

The powder processing technique:

Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 100 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, mixing, packing, promptly.

Pharmaceutical research

1. its mouse oral acute toxinology experiment: this square preparation its mouse oral acute toxinology experiment, abnormal response does not appear, and safe in utilization when being equivalent to 750 times of human dosage.

2. rabbit eye irritant test: no matter single or multiple administration there is no hyperemia, edema, photophobia and the phenomenon of shedding tears.

3. Cavia porcellus oral cavity and pharyngolaryngeal mucosa irritant test: no matter single or multiple administration, this square preparation does not all have congested and edema phenomenon to Cavia porcellus Cavia porcellus oral cavity and throat.

Pharmacodynamic study:

The inflammation-resisting itch-stopping test of this square preparation shows: Mice Auricle inflammation and rat paw edema are had significant inhibitory effect, and sufficient the itching of Cavia porcellus that histamine is caused also has significant inhibitory effect, illustrates that this product has the inflammation-resisting itch-stopping effect.

Clinical trial:

1, clinical data

Select acute and chronic pharyngitis and oral ulcer to have case 80 examples of wind-heat troubling and hyperactivity of deficient fire performance, through following up a case by regular visits to record, among the 160 routine patients, male's 78 examples, women's 82 examples, age 1-65 year, wind-heat troubling card person 94 examples wherein, syndrome of flaring up of deficient fire person 66 examples.(case very little)

2, treatment standard

(1) wind-heat troubling card (being equivalent to the acute pharyngolaryngitis in the modern medicine): onset is anxious, the course of disease is short, the patient has pharyngalgia, dysphagia, dryness and heat, performances such as thirsty heating, the visible pharyngeal hyperemia redness of toposcopy, dislike and stop up the redness of hanging down, pharynx rear wall follicle hypertrophy, or see the oral cavity, the pharyngolaryngeal mucosa ulcerate disease, red tip of the tongue, yellow and thin fur or thin fur, wiry and frequent pulse.

(2) syndrome of flaring up of deficient fire (being equivalent to the chronic pharyngolaryngitis in the modern medicine): patient's course of disease is long, and onset is slow, and pharyngalgia history is repeatedly arranged; Conscious dry pharynx pain, scorching hot, then aggravation of many speeches has dry cough sometimes, foreign body sensation, happiness drinking-water, but still feel dry, and to check and see that pharyngeal mucosa is kermesinus, mucosa drying or atrophy can have follicle hypertrophy sometimes, and the red tongue tongue is few, or slight crack is arranged, wiry and frequent pulse.

3, administrated method and observation index

1. usage: loose with precious first moistening and cleaning throat at every turn and aim at pharyngeal or ulcer place spray 1-3 time, must not have a drink and take food in half an hour for once in every 2-3 hour, 3 days is a course of treatment, the observation period must not dual-purpose other about medicine.

2. observational technique: adopt calm down mensuration, to cardinal symptom such as pharyngalgia, scorching hot dry foreign body sensation and sign such as pharyngeal hyperemia funiculus lateralis redness, follicle hypertrophy, secretions what, respectively by its order of severity, adopt level Four method record, promptly Sx very obviously the person be " +++", obvious person remembers with " ++ ", Sx does not have the person to remember with "+" slightly, asymptomatic or Absence of physical signs is with "-" note, with " +++" be 3 minutes, " ++ " is 2 minutes, "+" is 1 minute, "-" is 0 minute, and its score value is write down in further consultation after the course of treatment again, add up integration then, carry out date processing.

4, curative effect determinate standard: divide produce effects, effective, invalid three grades:

Produce effects: symptom and sign disappear or basic the disappearance after the medication, and integration reduces by 2/3rds above persons.

Effectively: symptom and sign are more preceding after the medication obviously alleviates, and integration reduces more than 1/2nd, but less than 1/3rds.

Invalid: symptom and sign do not have significantly and alleviate before the medication, and integration reduces less than 1/2nds.

5, matched group

The GUILIN XIGUA SHUANG matched group is set up in this checking, and matched group amounts to 40 examples, male's 24 examples, and women's 16 examples, wind-heat troubling person 24 examples wherein, hyperactivity of deficient fire person 16 examples, case choice criteria medication and curative effect determinate standard are the same.

6, therapeutic outcome: as table

Powder group of the present invention:

	Produce effects	Effectively	Invalid	Total routine number	Total effective rate
						The total routine number of wind-heat troubling type asthenic fire flaring up type	52 55.3％ 34 51.5％ 86 53.8％	34 36.2％ 20 30.3％ 54 33.7％	8 8.5％ 12 18.2％ 20 12.5％	94 66 160	91.5％ 81.8％ 87.5％

The GUILIN XIGUA SHUANG matched group:

	Produce effects	Effectively	Invalid	Total routine number	Total effective rate
						The total routine number of wind-heat troubling type asthenic fire flaring up type	12 55.0％ 4 25.0％ 16 40.0％	8 33.3％ 8 50.0％ 16 40.0％	4 16.7％ 4 25.0％ 8 20.0％	24 16 40	83.3％ 75.0％ 80.0％

The clinical use of last table shows:

1. preparation of the present invention all has tangible curative effect to acute and chronic pharyngitis, oral ulcer, total effective rate to pharyngolaryngitis is 87.5%, wherein obvious effective rate is 53.8%, carry out the X2 check with the GUILIN XIGUA SHUANG contrast, P＜0.01, the GUILIN XIGUA SHUANG that is better than evident in efficacy all has in various degree therapeutic effect to the various symptoms of pharyngolaryngitis.

2. do not find side effect or sense of discomfort in this product 160 routine clinical uses.

Below further set forth the preparation method of medicine of the present invention by specific embodiment.

Embodiment 1-3: powder (unit: gram.Down together)

[embodiment 1] Margarita powder 320, Radix Scrophulariae 64, Cortex Phellodendri 64, Indigo Naturalis 128, Galla Chinensis 128, Alumen (forging) 32, Radix Glycyrrhizae 96, Mentholum 32, Borneolum Syntheticum 96, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 10 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, mixing, packing, promptly.

[embodiment 2] Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 100 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, mixing, packing, promptly.

[embodiment 3] Margarita powder 480, Radix Scrophulariae 96, Cortex Phellodendri 96, Indigo Naturalis 192, Galla Chinensis 192, Alumen (forging) 48, Radix Glycyrrhizae 144, Mentholum 48, Borneolum Syntheticum 144, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 100 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, mixing, packing, promptly.

Embodiment 4-6: tablet

[embodiment 4] Margarita powder 320, Radix Scrophulariae 64, Cortex Phellodendri 64, Indigo Naturalis 128, Galla Chinensis 128, Alumen (forging) 32, Radix Glycyrrhizae 96, Mentholum 32, Borneolum Syntheticum 96, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 distinguish the flavor of in 100 ℃ the baking 1 hour, pulverize, cross sieve No. 7, add Margarita powder, mixing, put 100 ℃ and dry by the fire half an hour, put coldly, 30 POVIDONE K 30 BP/USP 30 alcoholic solution with 10% are granulated, drying, granulate, add the alcoholic solution of Borneolum Syntheticum, Mentholum, stir evenly airtight 48 hours, add magnesium stearate, mixing, tabletting, promptly.

[embodiment 5] Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 distinguish the flavor of in 100 ℃ the baking 1 hour, pulverize, cross sieve No. 7, add Margarita powder, mixing, put 100 ℃ and dry by the fire half an hour, put coldly, 30 POVIDONE K 30 BP/USP 30 alcoholic solution with 10% are granulated, drying, granulate, add the alcoholic solution of Borneolum Syntheticum, Mentholum, stir evenly airtight 48 hours, add magnesium stearate, mixing, tabletting, promptly.

[embodiment 6] Margarita powder 480, Radix Scrophulariae 96, Cortex Phellodendri 96, Indigo Naturalis 192, Galla Chinensis 192, Alumen (forging) 48, Radix Glycyrrhizae 144, Mentholum 48, Borneolum Syntheticum 144, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 distinguish the flavor of in 100 ℃ the baking 1 hour, pulverize, cross sieve No. 7, add Margarita powder, mixing, put 100 ℃ and dry by the fire half an hour, put coldly, 30 POVIDONE K 30 BP/USP 30 alcoholic solution with 10% are granulated, drying, granulate, add the alcoholic solution of Borneolum Syntheticum, Mentholum, stir evenly airtight 48 hours, add magnesium stearate, mixing, tabletting, promptly.

Embodiment 7-9: solution

[embodiment 7] Margarita powder 320, Radix Scrophulariae 64, Cortex Phellodendri 64, Indigo Naturalis 128, Galla Chinensis 128, Alumen (forging) 32, Radix Glycyrrhizae 96, Mentholum 32, Borneolum Syntheticum 96, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, Alumen (forging), the decocting that 5 flavors such as all the other Galla Chinensiss add 10 times of amounts boils secondary, and 1 hour for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is condensed into magma, and proportion is 1.05～1.25 (20 ℃), the alcoholic solution that adds 4 flavor medicines such as Margarita powder, mixing, packing, promptly.

[embodiment 8] Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, Alumen (forging), the decocting that 5 flavors such as all the other Galla Chinensiss add 10 times of amounts boils secondary, and 1 hour for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is condensed into magma, and proportion is 1.05～1.25 (20 ℃), the alcoholic solution that adds 4 flavor medicines such as Margarita powder, mixing, packing, promptly.

[embodiment 9] Margarita powder 480, Radix Scrophulariae 96, Cortex Phellodendri 96, Indigo Naturalis 192, Galla Chinensis 192, Alumen (forging) 48, Radix Glycyrrhizae 144, Mentholum 48, Borneolum Syntheticum 144, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, Alumen (forging), the decocting that 5 flavors such as all the other Galla Chinensiss add 10 times of amounts boils secondary, and 1 hour for the first time, 1 hour for the second time, collecting decoction, filter, filtrate is condensed into magma, and proportion is 1.05～1.25 (20 ℃), the alcoholic solution that adds 4 flavor medicines such as Margarita powder, mixing, packing, promptly.

Embodiment 10-11: gel

[embodiment 10] Margarita powder 320, Radix Scrophulariae 64, Cortex Phellodendri 64, Indigo Naturalis 128, Galla Chinensis 128, Alumen (forging) 32, Radix Glycyrrhizae 96, Mentholum 32, Borneolum Syntheticum 96, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, cross sieve No. 7, add Margarita powder, mixing, put 100 ℃ and dry by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing, cross sieve No. 7, be mixed and made into 5000 milliliters in semifluid preparation with an amount of water-soluble base-hypromellose, promptly.

[embodiment 11] Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, cross sieve No. 7, add Margarita powder, mixing, put 100 ℃ and dry by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing, cross sieve No. 7, be mixed and made into 5000 milliliters in semifluid preparation with an amount of water-soluble base-hypromellose, promptly.

Embodiment 12-13: membrane

[embodiment 12] Margarita powder 320, Radix Scrophulariae 64, Cortex Phellodendri 64, Indigo Naturalis 128, Galla Chinensis 128, Alumen (forging) 32, Radix Glycyrrhizae 96, Mentholum 32, Borneolum Syntheticum 96, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 100 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, and is even with an amount of interior olefin(e) acid mixed with resin, make membrane, packing promptly.

[embodiment 13] Margarita powder 400, Radix Scrophulariae 80, Cortex Phellodendri 80, Indigo Naturalis 160, Galla Chinensis 160, Alumen (forging) 40, Radix Glycyrrhizae 120, Mentholum 40, Borneolum Syntheticum 120, more than nine the flavor, except that Margarita powder, Borneolum Syntheticum, Mentholum, all the other Galla Chinensiss etc. 6 are distinguished the flavor of in 100 ℃ of bakings 1 hour, pulverize, and cross sieve No. 7, add Margarita powder, mixing is put 100 ℃ and is dried by the fire half an hour, put coldly, add Borneolum Syntheticum, Mentholum, ball mill pulverizing is crossed sieve No. 7, with an amount of acrylic resin mix homogeneously, make membrane, packing promptly.

Claims (2)

1, a kind of Chinese medicine composition and preparation thereof for the treatment of oral inflammation is characterized in that raw material components and weight proportion that its compositions or preparation contain are:

Margarita powder 320～480 gram Radix Scrophulariaes 64～96 gram Cortex Phellodendris 64～96 grams

Indigo Naturalis 128～192 gram Galla Chinensiss 128～192 gram Alumens (forging) 32～48 grams

Radix Glycyrrhizae 96～144 gram Mentholums 32～48 gram Borneolum Syntheticums 96～144 grams.

2,, it is characterized in that the raw material components optimum weight proportioning that its compositions or preparation contain is according to the Chinese medicine composition and the preparation thereof of the described treatment oral inflammation of claim 1:

Margarita powder 400 gram Radix Scrophulariaes 80 gram Cortex Phellodendris 80 grams

Indigo Naturalis 160 gram Galla Chinensiss 160 gram Alumens (forging) 40 grams

Radix Glycyrrhizae 120 gram Mentholums 40 gram Borneolum Syntheticums 120 grams.