CN101342312B - Medicament for treating pharyngitis and method for preparing the same - Google Patents
Medicament for treating pharyngitis and method for preparing the same Download PDFInfo
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Abstract
The present invention relates to a Chinese medicinal preparation, in particular to a medicine which is used for treating acute and chronic pharyngitis, and a preparation method thereof. The medicine is mainly prepared from honeysuckle, dwarf lilyturf root, balloon-flower root and so on in the form of granular particles of Yinju, and has the functions of clearing away the heat-evil, expelling superficial evils, benefiting swallowing, clearing the voice, and so on. Moreover, the medicine has significant effects on acute and chronic pharyngitis, and is suitable for wide promotion and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of medicine and preparation and using method for the treatment of acute/chronic pharyngitis.
Background technology
Pharyngitis often is the part of respiratory inflammation, and the general course of disease is tediously long, and is obstinate difficult, and the branch of acute and chronic pharyngitis is arranged, and acute pharyngitis shows effect repeatedly, treat untimely promptly transfer to chronic.Primary disease is equivalent to the category of Chinese medicine " sore throat ", tcm clinical practice often because of wind heat attack accumulate in lung or hyperactivity of deficient fire or the pyretic toxicity due to.Clinical common sympton is: pharyngeal little redness, pharyngalgia, dry pharynx, itching throat are scorching hot, foreign body in pharynx sense or stop up sense.
Western medicine is mainly based on antibiotics at present, and the western medical treatment pharyngolaryngitis is disease controlling temporarily, can not obtain the effect for the treatment of both the principal and the secondary aspects of a disease at the same time.Take antibiotic for a long time and can have side effects and cause the human body imbalance of YIN and YANG, dyshormonia takes place, body immunity is descended, the health anti-virus ability is low, and resistance against diseases is poor, and the difficult repeatedly more final trend of the state of an illness is worsened, and leads to complications simultaneously.Chinese medicine is with heat-clearing and toxic substances removing, nourishing YIN and clearing away lung-heat, promote the production of body fluid moisturize, method such as activating QI to eliminate phlegm is for controlling.Treating both the principal and the secondary aspects of a disease at the same time, the clinical observation short treating period, no side reaction, safe and reliable, prove effective rapidly.But the Chinese medicine of existing treatment acute/chronic pharyngitis is because complicated component and mostly be decoction, inconvenience when patient uses, and the effective ingredient in many medicines is owing to the error of decocting method is run off, thus reduced drug effect.Other as dosage forms such as buccal sheets, though can alleviate patient's symptom at short notice, can't play the purpose of radical cure, also just can't effectively treat acute/chronic pharyngitis.
Summary of the invention
Treatment present situation and existing problems for the treatment of the medicine existence of acute/chronic pharyngitis at present and chronic pharyngitis, the invention provides a kind of medicine and preparation and using method for the treatment of acute/chronic pharyngitis, this medicine as principal agent, is finally made granular silver-colored Fructus Citri tangerinae granule with Flos Lonicerae, Radix Ophiopogonis, Radix Platycodonis etc.This medicine has effects such as heat-clearing and toxic substances removing, sore-throat relieving sore throat relieving, and acute/chronic pharyngitis is had significant curative effect, is fit to promote widely and use.
Particular content of the present invention is: a kind of medicine silver Fructus Citri tangerinae granule for the treatment of pharyngitis, the main components in percentage by weight of described medicine is by weight: Flos Lonicerae 18-22 part, Radix Ophiopogonis 18-22 part, Rhizoma Menispermi 3-10 part, Radix Scrophulariae 13-16 part, Fructus Canarii 18-22 part, Radix Platycodonis 8-12 part, Semen Sterculiae Lychnophorae 8-12 part, Radix Glycyrrhizae 8-12 part, cane sugar powder 12-15 part, dextrin 1-3 part.
Optimum ratio is: 20 parts of Flos Loniceraes, 20 parts of Radix Ophiopogonis, 9 parts of Rhizoma Menispermis, 15 parts of Radix Scrophulariaes, 20 parts of Fructus Canariis, 10 parts of Radix Platycodoniss, 10 parts of Semen Sterculiae Lychnophoraes, 10 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 3 parts in dextrin.
In the above-mentioned prescription: Flos Lonicerae is sweet cold, heat-clearing and toxic substances removing, and wind-heat dissipating, Radix Ophiopogonis, sweet little hardship was slightly cold, YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire and is monarch drug; The Rhizoma Menispermi bitter cold, heat-clearing and toxic substances removing, the detumescence sore-throat relieving is used for that fire-toxin pents up, laryngopharynx swelling and pain; Radix Scrophulariae sweetness and bitterness is salty to be slightly cold, removing heat from blood YIN nourishing, eliminating fire and detoxication; Semen Sterculiae Lychnophorae is sweet cold, clearing heat and moistening lung, liyan jiedu; Fructus Canarii is ministerial drug altogether; The Radix Platycodonis toil is flat, lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus, priming be up; Radix Glycyrrhizae is sweet flat, invigorating the spleen and replenishing QI, and heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription makes for assistant altogether.
Adopt the various raw materials of said ratio, combine the drug effect of the Chinese medicine of respectively distinguishing the flavor of, reasonably collocation makes the more thorough of drug effect performance, the counteracting of the drug effect between Chinese medicine of having prevented from simultaneously respectively to distinguish the flavor of.The utilization modern pharmacology carries out pharmacodynamic study to silver-colored Fructus Citri tangerinae granule, and this preparation has raise immunity effect, antiinflammatory action, bacteriostasis.Because the cost of various raw materials is lower, be fit to large-scale production, made things convenient for more patients' use.
The preparation technology of this medicine is:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 75-85 ℃, and preferred 80 ℃, the time of immersion is: 1-1.5 hour, preferred 1 hour, water consumption was 18-22 a times of Semen Sterculiae Lychnophorae quality, preferred 20 times, soaked and finished back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to said ratio after, add the water that above-mentioned medical material gross weight 7-8 doubly measures, the water of preferred 8 times of amounts begins to decoct after soaking 0.5h, decocting time is: 1.5-2h; Filter, get filtrate; Medicinal residues add the water that above-mentioned medical material gross weight 4-6 doubly measures, and the water of preferred 6 times of amounts carries out decocting the second time, and decocting time is 1-1.5h, and preferred 1.5 hours, filter, get filtrate, twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, the relative density 1.35～1.39 of gained thick paste, in thick paste, add cane sugar powder, dextrin, become granule, drying with No. 1 sieve series behind the mixing according to proportioning, granulate can make silver-colored Fructus Citri tangerinae granule.
Adopt above preparation technology mainly according to following reason:
(1) Semen Sterculiae Lychnophorae contains phlegmatic temperament, and swelling degree is bigger in the water, fries in shallow oil altogether with the other medicines in the side, influences the extraction of other medicines effective ingredient; Contain polysaccharide in the Semen Sterculiae Lychnophorae in addition simultaneously, the temperature when frying in shallow oil altogether is too high, and polysaccharide easily decomposes, and therefore adopts the method for the independent warm macerating of Semen Sterculiae Lychnophorae;
(2) all medicines of silver-colored Fructus Citri tangerinae granule prescription mainly contain effective ingredient such as flavonoid, organic acid, saponin, alkaloid, saccharide, aminoacid, character according to mentioned component, take the water boiling and extraction method, for the main component of various medicines being extracted fully by the water boiling and extraction method, parameters among the preparation technologies such as soak time, decoction number of times, decocting time and amount of water is set at each above-mentioned value, make that like this each the effective elements of the medicine is effectively extracted, the silver-colored Fructus Citri tangerinae granule drug effect of gained obtains maximum performance;
(3) sucrose is excipient, also plays the effect of flavoring simultaneously in silver-colored Fructus Citri tangerinae granule.Add a small amount of highly-water-soluble dextrin, when the system granule, both played adhesive effect, make granule can be dissolved in water rapidly again.
Pelletize described in the present invention and drying all adopt prior art, and the equipment that is adopted is the equipment for buying on the market also.
The silver-colored Fructus Citri tangerinae granule of gained, its using method is: every day 3 times, the 8-10 gram of being grown up a time, the child reduces by half and takes, and 7 days is a course of treatment, takes continuously and treats three courses of treatment.Take points for attention: quit smoking during take (1), wine, pungent, raw and cold food.(2) diabetics forbidding.(3) old, Deficiency and coldness of spleen and stomach, the careful usefulness of loose stool person.
Owing to adopted above-mentioned drug ratio and preparation, using method, brought into play the drug effect of Chinese medicine to the full extent, this medicine is the compound recipe pure Chinese medicinal preparation, has effects such as heat-clearing and toxic substances removing, sore-throat relieving sore throat relieving, acute/chronic pharyngitis there is curative effect preferably, and side effect is little, and is less to the influence of patient body, is fit to promote widely and use, through the tracing observation after the patient is taken medicine, medication posterior phraynx inflammation shape obviously alleviates, and inflammation disappears, and effective percentage is 96%.As seen its curative effect than existing various treatment pharyngitis medicine be significantly improved, simultaneously, made things convenient for taking and carrying of patient owing to adopted the granule dosage form, cost is low to be suitable for a large amount of popularizations and use.
The specific embodiment
Embodiment 1
A kind of medicine silver Fructus Citri tangerinae granule for the treatment of pharyngitis, the main components in percentage by weight of described medicine proportioning by weight is: 20 parts of Flos Loniceraes, 20 parts of Radix Ophiopogonis, 9 parts of Rhizoma Menispermis, 15 parts of Radix Scrophulariaes, 20 parts of Fructus Canariis, 10 parts of Radix Platycodoniss, 10 parts of Semen Sterculiae Lychnophoraes, 10 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 3 parts in dextrin.
Add man-hour, its processing method is as follows:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 80 ℃, and the time of immersion is 1 hour, and water consumption is 20 times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to said ratio after, after adding 8 times of water gagings of above-mentioned medical material gross weight and soaking 0.5h, begin to decoct, decocting time is 2h in decocting first; Filter, get filtrate; Medicinal residues add the water of 6 times of amounts of above-mentioned medical material gross weight, carry out decocting the second time, and decocting time is preferred 1.5 hours, filters, and gets filtrate.Twice filtrate merges.
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, and gained thick paste relative density is 1.36, in thick paste, add cane sugar powder, dextrin, become granule, drying with No. 1 sieve series behind the mixing according to proportioning, granulate can make silver-colored Fructus Citri tangerinae granule.
Embodiment 2
A kind of medicine silver Fructus Citri tangerinae granule for the treatment of pharyngitis, the main components in percentage by weight of described medicine is by weight: 18 parts of Flos Loniceraes, 18 parts of Radix Ophiopogonis, 3 parts of Rhizoma Menispermis, 13 parts of Radix Scrophulariaes, 18 parts of Fructus Canariis, 8 parts of Radix Platycodoniss, 8 parts of Semen Sterculiae Lychnophoraes, 8 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 1 part in dextrin.
The preparation method of this medicine is:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 75 ℃, and the time of immersion is 1 hour, and water consumption is 18 times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to said ratio after, begin to decoct after adding the water logging bubble 0.5h of 7 times of amounts of above-mentioned medical material gross weight; Decocting time is first: 1.5; Filter, get filtrate; Medicinal residues add 5 times of water gagings of above-mentioned medical material gross weight, carry out decocting the second time, and decocting time is 1h, filters, and gets filtrate; Twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, and the relative density of gained thick paste is 1.35, in thick paste, add cane sugar powder, dextrin according to proportioning, become granule with No. 1 sieve series behind the mixing, drying, granulate can make silver-colored Fructus Citri tangerinae granule.
Embodiment 3
A kind of medicine silver Fructus Citri tangerinae granule for the treatment of pharyngitis, the main components in percentage by weight of described medicine is by weight: 22 parts of Flos Loniceraes, 22 parts of Radix Ophiopogonis, 10 parts of Rhizoma Menispermis, 16 parts of Radix Scrophulariaes, 22 parts of Fructus Canariis, 12 parts of Radix Platycodoniss, 12 parts of Semen Sterculiae Lychnophoraes, 12 parts in Radix Glycyrrhizae, 15 parts of cane sugar powders, 3 parts in dextrin
The preparation method of this medicine is:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 85 ℃, and the time of immersion is 1.5 hours, and water consumption is 22 times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to said ratio after, begin to decoct after adding the water logging bubble 0.4h of 9 times of amounts of above-mentioned medical material gross weight; Decocting time is first: 2h; Filter, get filtrate; Medicinal residues add 6 times of water gagings of above-mentioned medical material gross weight, carry out decocting the second time, and decocting time is 1.5h, filters, and gets filtrate; Twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, and the relative density of gained thick paste is 1.38, in thick paste, add cane sugar powder, dextrin according to proportioning, become granule with No. 1 sieve series behind the mixing, drying, granulate can make silver-colored Fructus Citri tangerinae granule.
Embodiment 4
A kind of medicine silver Fructus Citri tangerinae granule for the treatment of pharyngitis, the main components in percentage by weight of described medicine is by weight: 21 parts of Flos Loniceraes, 19 parts of Radix Ophiopogonis, 6 parts of Rhizoma Menispermis, 14 parts of Radix Scrophulariaes, 21 parts of Fructus Canariis, 9 parts of Radix Platycodoniss, 9 parts of Semen Sterculiae Lychnophoraes, 9 parts in Radix Glycyrrhizae, 13 parts of cane sugar powders, 2 parts of aleurones
The preparation method of this medicine is:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 82-83 ℃, and the time of immersion is 1.2 hours, and water consumption is 19 times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to said ratio after, begin to decoct after adding the water logging bubble 0.5h of 9 times of amounts of above-mentioned medical material gross weight; Decocting time is first: 1.8h; Filter, get filtrate; Medicinal residues add 5.5 times of water gagings of above-mentioned medical material gross weight, carry out decocting the second time, and decocting time is 1.2h, filters, and gets filtrate; Twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, and the relative density of gained thick paste is 1.37, in thick paste, add cane sugar powder, dextrin according to proportioning, become granule with No. 1 sieve series behind the mixing, drying, granulate can make silver-colored Fructus Citri tangerinae granule.
Comparative example:
Outpatient service is diagnosed as patient's 152 examples of acute/chronic pharyngitis, male's 63 examples, and women's 89 examples, age characteristics was at 16-60 years old.Divide two groups at random.Wherein 102 examples are organized in treatment, matched group 50 examples.
Oral embodiment 1 prepared silver-colored Fructus Citri tangerinae granule is organized in treatment, each 10g, every day 3 times; Matched group buccal QINGYAN DIWAN, one time 5 ball, 3 times on the one, every group equal seven days be a course of treatment.
Contrast standard: medication is after 3 days, and dry pharynx, pharyngalgia, cough, foreign body in pharynx sense obviously alleviate, and inflammation disappears, and sb.'s illness took a favorable turn is effective.More than 5 days symptom do not have alleviate be improved as invalid.
Contrast and experiment sees the following form:
The clinical observation on the therapeutic effect table
See that from the result treatment group is better than matched group.The more existing medicine curative effect of silver-colored Fructus Citri tangerinae granule of treatment pharyngitis as seen provided by the present invention is enhanced.
Claims (4)
1. medicine for the treatment of pharyngitis, it is characterized in that: its composition proportion by weight: Flos Lonicerae 18-22 part, Radix Ophiopogonis 18-22 part, Rhizoma Menispermi 3-10 part, Radix Scrophulariae 13-16 part, Fructus Canarii 18-22 part, Radix Platycodonis 8-12 part, Semen Sterculiae Lychnophorae 8-12 part, Radix Glycyrrhizae 8-12 part, cane sugar powder 12-15 part, dextrin 1-3 part.
2. medicine according to claim 1, it is characterized in that: the composition proportion of described medicine is: 20 parts of Flos Loniceraes, 20 parts of Radix Ophiopogonis, 9 parts of Rhizoma Menispermis, 15 parts of Radix Scrophulariaes, 20 parts of Fructus Canariis, 10 parts of Radix Platycodoniss, 10 parts of Semen Sterculiae Lychnophoraes, 10 parts in Radix Glycyrrhizae, 12 parts of cane sugar powders, 3 parts in dextrin.
3. the preparation method of the medicine of a treatment pharyngitis as claimed in claim 1, it is characterized in that: its method is:
(1) with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 75-85 ℃, and the time of immersion is 1-1.5 hour, and water consumption is 18-22 a times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to proportioning after, add the water that above-mentioned medical material gross weight 7-8 doubly measures, begin to decoct after soaking 0.5h, decocting time is: 1.5-2h; Filter, get filtrate; Add 4-6 times of water gaging of above-mentioned medical material gross weight in the medicinal residues, carry out decocting the second time, decocting time is 1-1.5h, filters, and gets filtrate, and twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, the relative density 1.35～1.39 of gained thick paste, in thick paste, add cane sugar powder, dextrin according to proportioning, become granule with No. 1 sieve series behind the mixing, drying, granulate can make silver-colored Fructus Citri tangerinae granule.
4. the preparation method of the medicine of treatment pharyngitis according to claim 3 is characterized in that: the preparation method of this medicine is:
(1). with the Semen Sterculiae Lychnophorae warm macerating of said ratio, the temperature of immersion is 80 ℃, and the time of immersion is 1 hour, and water consumption is 20 times of Semen Sterculiae Lychnophorae quality, soaks and finishes back filtration, filtrate for later use;
(2) Flos Lonicerae, Radix Ophiopogonis, Rhizoma Menispermi, Radix Scrophulariae, Fructus Canarii, Radix Platycodonis, Radix Glycyrrhizae are mixed according to proportioning after, begin to decoct after adding the water logging bubble 0.5h of 8 times of amounts of above-mentioned medical material gross weight, decocting time is: 2h; Filter, get filtrate; Medicinal residues add the water of 6 times of amounts of above-mentioned medical material gross weight, carry out decocting the second time, and decocting time is 1.5 hours, filters, and gets filtrate; Twice filtrate merges;
(3) with Semen Sterculiae Lychnophorae filtrate in the step 1 and the filtrate mix homogeneously in the step 2, gained filtrate is condensed into thick paste, the relative density 1.35～1.39 of gained thick paste, in thick paste, add cane sugar powder, dextrin according to proportioning, become granule with No. 1 sieve series behind the mixing, drying, granulate can make silver-colored Fructus Citri tangerinae granule.
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| CN101732584B (en) * | 2010-01-20 | 2011-04-20 | 张伟 | Throat disinhibiting bagged soaking preparation for treating pharyngitis |
| CN101940246A (en) * | 2010-07-24 | 2011-01-12 | 刘爱武 | Honeysuckle throat-moistening tea |
| CN102988903B (en) * | 2012-12-20 | 2014-04-23 | 孟凡玉 | Traditional Chinese medicine composition for treating chronic pharyngitis |
| CN103584115B (en) * | 2013-11-07 | 2015-10-28 | 王昆磊 | Clearing is except haze health food |
| CN103585446A (en) * | 2013-11-20 | 2014-02-19 | 钱家美 | Traditional Chinese medicineatomizing agent formula for treating pharyngitis |
| CN104784526A (en) * | 2015-04-01 | 2015-07-22 | 济南正骐生物科技有限公司 | Traditional Chinese medicine for treating globus hysteriocus and preparation method thereof |
| CN105709109A (en) * | 2016-04-18 | 2016-06-29 | 孙娟 | Traditional Chinese medicine composition for clearing throat and relieving sore-throat and capsules and preparation method thereof |
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| 周郑坤等.胖大海水溶性多糖的提取.《西北林学院学报》.2006,第21卷(第4期),129-131. * |
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