CN102948748A - Anti-fatigue health care product - Google Patents

Anti-fatigue health care product Download PDF

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CN102948748A
CN102948748A CN2012104395082A CN201210439508A CN102948748A CN 102948748 A CN102948748 A CN 102948748A CN 2012104395082 A CN2012104395082 A CN 2012104395082A CN 201210439508 A CN201210439508 A CN 201210439508A CN 102948748 A CN102948748 A CN 102948748A
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parts
health care
health products
extract
antifatigue
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郦红岩
赵雷
陈建
兰雪莲
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JIANGSU JIBEIER PHARM CO Ltd
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JIANGSU JIBEIER PHARM CO Ltd
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Abstract

The invention discloses an anti-fatigue health care product which is prepared from raw materials in parts by weight as follows: 10-40 parts of medlar extract, 10-30 parts of worm grass extract, 5-30 parts of lucid ganoderma extract, 10-30 parts of poria cocos extract and 5-20 parts of Astragalus mongholicus extract. The principle components of the health care product provided by the invention are from medical and edible natural plants, and polysaccharide components in the natural plants are mainly extracted by adopting modern extraction technologies. Through scientific combination of the raw materials, the health care product provided by the invention has the remarkably anti-fatigue effect, enhances the body strength, covers the consumption and meanwhile has the health care and subsidiary effect, and enhances the immune function and promotes sleep.

Description

A kind of health products of antifatigue
Technical field
The present invention relates to a kind of health products, particularly a kind of health products of antifatigue.
Background technology
Chronic fatigue syndrome refers to a kind of long-term fatigue and weak state that fatigue causes, a series of syndromes such as the general malaise that can not alleviate by lying up, One's spirits are drooping, brothers are aching and limp, memory is not concentrated, inefficiency.The incidence of disease in China is 10%-20%, in the industries such as science and technology, news, advertisement, civil servant, performing art, taxi-driver up to 50%.
Survey data shows, it is sharply soaring that compatriots are in the ratio of sub-health state, and especially managerial cadre, enterpriser, scientific worker, lawyer, doctor etc. mainly are to abandon over rural life with people and to change the modern life over to closely related.Social competition is fierce, and task is heavy, and a lot of people are in the tense situation of overload operation for a long time, and the body and mind overdraw is unusually serious, and rest and sleep quality can not get guarantee, and fatigue can not get effective alleviation.And modern's mode height of living is single, lacks to change to regulate, and is repeating same experience of life every day, forms a kind of life style of formulism, makes the body part N﹠M in tension for a long time, can not get loosening, and is very easily tired.In the traditional Chinese medical science, the generation of chronic fatigue syndrome mainly is the functional disturbance of liver spleen kidney, and in addition nervous for a long time, body and mind is tired, and inside and outside phase factor causes due to the energy and blood of human body yin and yang imbalance.Have data to show, overtired has been to cause the topmost reason of " inferior health " state.Eliminating fatigue is the effective way of walking out " inferior health " state.
Summary of the invention
Technical problem to be solved by this invention is based on the Traditional Chinese Medicine theory, uses modern extraction technique and in conjunction with modern Chinese herbal medicine length of schooling agent technique, provides a kind of health products of antifatigue.
The present invention is achieved by the following technical programs.
A kind of health products of antifatigue, it is the medicament of being made by the raw material of following weight proportion: wolfberry fruit extract 10-40 part, Cordyceps 10-30 part, Ganodenna Lucidum P.E 5-30 part, tuckahoe extracts 10-30 part, Astragalus Root P.E 5-20 part.
The health products of above-mentioned a kind of antifatigue, it is the medicament of being made by the raw material of following weight proportion: 30 parts of wolfberry fruit extracts, 10 parts of Cordyceps, 25 parts of Ganodenna Lucidum P.Es, 30 parts of tuckahoe extracts, 5 parts of Astragalus Root P.Es.
The health products of above-mentioned a kind of antifatigue, wherein, described formulation is soft capsule.
The health products of above-mentioned a kind of antifatigue, wherein, described formulation is hard shell capsules.
The health products of above-mentioned a kind of antifatigue, wherein, described formulation is tablet.
The health products of above-mentioned a kind of antifatigue, wherein, described formulation is granule.
Health products of the present invention are the principles according to " integration of drinking and medicinal herbs ", in conjunction with the modern nutriology basis, purify and develop through scientific and reasonable technique, health products of the present invention are prepared from take wolfberry fruit extract, Cordyceps, Ganodenna Lucidum P.E, tuckahoe extracts and Astragalus Root P.E as raw material.
The fruit of Chinese wolfberry is a kind of natural medicinal and edible plant, belong to nourishing liver and kidney class medicine, being mainly used in clinically treating the consumptive disease essence loses, soreness of waist and knee joint, dizzy tinnitus, sallow disease, the especially LBP-X of waiting of the deficiency of blood, have widely pharmacological action, as strengthen immunity, fatigue-relieving, antitumor, fat-reducing liver-protecting, improvement memory etc.Mainly contain LBP-X, carotenoid, thiamine, riboflavin, ascorbic acid, betaine in the wolfberry fruit extract, also contain the elements such as abundant potassium, sodium, calcium, magnesium, iron, copper, manganese, zinc, and several amino acids and multivitamin.Active ingredient is LBP-X.
Cordyceps sinensis is a kind of natural rare Chinese medicine invigorant, the medical science analysis, and cordycep includes cobalamin, fat, albumen etc.Chinese caterpillar fungus property is sweet, Wen Ping, nontoxic, is famous strengthening by means of tonics medicine, meat boiled dinner commonly used, the effect that has qi-restoratives to be healthy and strong.Be applicable to treat spitting of blood due to Lung Qi deficiency and deficiency of both the lung and kidney, the pulmonary tuberculosis etc. or blood-stained sputum, cough.Breathe hard, night sweat etc., impotence due to deficiency of the kidney, waist knee ache etc. is also had good curative effect, the person's that also is the oldaged physically weak excellent tonic product.Modern clinical research shows, Chinese caterpillar fungus has immunological regulation, antitumor, antifatigue, adjusting hepatic and renal function, reducing blood lipid, adjusting hematopoiesis function etc.The nutriment that contains Cordyceps sinensis polysaccharide, sweet mellow wine, amino acid, multivitamin and other multiple needed by human in the Cordyceps.Main functional component is Cordyceps sinensis polysaccharide, the polysaccharide that is comprised of mannose, cordycepin, adenosine, galactolipin, arabinose, wood sugar essence, glucose, fucose.
Glossy ganoderma is the treasure in motherland's pools of traditional Chinese medicine, and at all times pharmacology and clinical research all proves, the effect that glossy ganoderma truly has and prevents and cures diseases, promotes longevity.Modern pharmacology and clinical practice have further confirmed the pharmacological action of glossy ganoderma, and confirm that GL-B is that glossy ganoderma is strengthened the body resistance to consolidate the constitution, strengthening by means of tonics, the main component of promoting longevity.Contain GL-B, ganoderic acid, adenosine, lactones, organic germanium in the Ganodenna Lucidum P.E; triterpenes, sweet mellow wine, the compositions such as the spore ether in ergosterol, black alcohols, taurine, ganoine Ⅰ, ganoine Ⅱ, uracil and uridine, adenosine, adenine, oleic acid, glossy ganoderma total alkali, the Reishi sporule and cellulose.GL-B is main composition, take beta glucan as main, contains a small amount of wood sugar and arabinose.
Poria cocos is a kind of traditional Chinese medicine, is the raw material of multiple prescription and Chinese patent drug, and saying of " ten medicines, nine Poria cocos " arranged, and its property is sweet light, and flavor is flat, is listed in since ancient times excellent tonic product.Be mainly used in clearing damp and promoting diuresis, invigorating the spleen on the tcm clinical practice, reduce phlegm, antitoxic heart-soothing and sedative.Modern medicine proof Poria cocos is significantly improved effect to the immunity degradation that causes because of fatigue, and finds that pachymaran is to the good effect that delayed senility.Tuckahoe extracts contains pachymic acid, TA, eburicoic acid, the acid of loose Siberian cocklebur, loose Siberian cocklebur eo-acid, pachyman etc.Be mainly the polysaccharide composition.
The Radix Astragali is a kind of famous and precious Chinese medicine, also is a kind of the most frequently used Chinese medicine, is celebrated with " all medicines of tonifying Qi ".Be mainly used in clinically treating the deficiency of vital energy weak, the sinking of qi of middle-jiao is rushed down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, and the exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts for a long time and does not hold back, and the deficiency of blood is sallow, and interior heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.Modern pharmacological research shows, the functions such as the Radix Astragali has immunity of organism, the anti-anoxic of enhancing, promotes organism metabolism, improves heart function, step-down protects the liver, regulate blood sugar, antifatigue.The main component of Astragalus Root P.E is the folic acid of astragalus polyose, Astragaloside IV, flavones, choline, betaine, amino acid, sucrose, glucuronic acid and trace.
Because these extracts are mainly take the polysaccharide composition as main, so extracting method is basically identical, and are roughly as follows:
Raw material adds the water refluxing extraction after washing, drying, coarse crushing, extract is concentrated, adds the ethanol precipitation, leaves standstill rear filtration, and with the sediment washing, vacuum drying is pulverized and is extract.
Extracting method is seen Figure of description.
The main component of health products of the present invention is used modern extraction technique from the natural plants that the medicine food shares, the main polysaccharide composition that extracts wherein.Health products of the present invention through the science combination, have significant antifatigue effect with above-mentioned raw materials, can strengthen muscle power, remedy consume, have simultaneously health care and booster action, can strengthen immunity function, promote sleep.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
The used raw material proportioning of embodiment 1-5 health products sees the following form:
Figure BSA00000801336200031
Health products of the present invention can be made into the formulations such as soft capsule, hard shell capsules, tablet and granule.According to the difference of formulation, can adopt various edible carrier, excipient and other additives.Such as available vegetable oil, antioxidant, suspending agent etc. in the soft capsule; Can add lubricant, anti-blushing agent, excipient etc. in the hard shell capsules; Can be with disintegrant, lubricant, excipient etc. in the tablet; Can add sweetener and flavouring etc. in the granule.
Preparation method take health products various formulation health products as example illustrates of implementing 1 raw material proportioning:
(1) preparation method of soft capsule:
Soft capsule material is added in the adhesive disolving tank, be heated to 70~85 ℃, stir and make dissolving, be evacuated to glue without bubble, for subsequent use 70 ℃ of insulations.Mix and add the raw material of embodiment 1 in the wheat-germ oil of 21g beeswax and 179g, mix and vacuumize 30 minutes at 40 ℃, then draw film, pelleting, capsule after pressing was finalized the design in rotating cage 1.5~3 hours, be no more than under 30% the condition dry 24 hours in 15~25 ℃ of temperature, relative humidity, get health products soft capsule of the present invention.Soft capsule net content of the present invention is the 0.5g/ grain, dose: every day 2 times, each 3.
(2) preparation method of hard shell capsules:
Raw material among the embodiment 1 is mixed by proportioning, add 10~20g superfine silica gel powder and 5~15g pregelatinized starch, mix, the edible ethanol with 90% is granulated, and drying is sieved, and incapsulates, and gets health products hard shell capsules of the present invention.Hard shell capsules net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
(3) preparation method of tablet:
Raw material among the embodiment 1 is mixed by proportioning, add 5~15g superfine silica gel powder, 5~15g pregelatinized starch and 5~10g calcium monohydrogen phosphate, mix, the edible ethanol solution with 90% is granulated, and drying is sieved, compressing tablet, and dressing gets troche of health products of the present invention.Tablet net content of the present invention is the 0.3g/ grain, dose: every day 2 times, each 2.
(4) preparation method of granule:
Raw material among the embodiment 1 is mixed by proportioning, add 200~300g granulated sugar powder, 250~400g starch, 300~400g dextrin and 5~15g stevioside, the edible ethanol with 85% is granulated, drying, and whole grain, pack gets health products granule of the present invention.Granule net content of the present invention is the 5g/ bag, dose: every day 2 times, each 1 bag.
Animal test results:
This product proves that through animal experiment it has the effect of antifatigue, and the result is as follows:
The variation of mice burden swimming time, serum urea nitrogen and hepatic glycogen deposit sees the following form:
Figure BSA00000801336200041
Annotate: compare * P<0.05, * * P<0.01 with control group.
As seen from the above table, heavy burden (5%) swimming time of each dosage group mouse of tested material is all than the prolongation of control group, wherein the difference of middle dosage group, low dose group and control group has significant (P<0.05 or P<0.01), shows that this tested material can prolong the swimming with a load attached to the body time of mouse; The mice serum urea nitrogen content of each dosage group of tested material all is lower than control group, and wherein the difference of low dose group and control group has significant (P<0.05), shows that this tested material can reduce or suppress tired mice serum urea nitrogen and produce; Each dosage group Mouse Liver glycogen content of tested material all is higher than control group, and with the difference of control group significant (P<0.05 or P<0.01) is arranged all, shows that this tested material has the effect that promotes the hepatic glycogen deposit.
Each is organized, and the variation of blood lactic acid (mmol/L) sees the following form behind the mouse movement:
Figure BSA00000801336200051
Annotate: compare * P<0.05, * * P<0.01 with control group.
As seen from the above table, blood Lactate difference not statistically significant when quiet between each group of test, and the blood Lactate of the rear 0min of each dosage group motion and these 2 time points of rest 20min all is starkly lower than control group, difference all has significant (P<0.05 or P<0.01), shows that this tested material can reduce Serum lactic acid content behind the mouse movement.
Above test shows, health products of the present invention can improve the human body energy metabolism, accelerates hepatic glycogen and decomposes energy supply, reduces protein and nitrogen-containing compound and decomposes, thereby reduce blood urea nitrogen, has antifatigue effect.
Here description of the invention and application is illustrative, is not to want that therefore, the present invention is not subjected to the restriction of the present embodiment with scope restriction of the present invention in the above-described embodiments, and the technical scheme that any employing equivalence replacement obtains is all in the scope of protection of the invention.

Claims (6)

1. the health products of an antifatigue is characterized in that, it is to be made by the raw material of following weight proportion: wolfberry fruit extract 10-40 part, Cordyceps 10-30 part, Ganodenna Lucidum P.E 5-30 part, tuckahoe extracts 10-30 part, Astragalus Root P.E 5-20 part.
2. the health products of a kind of antifatigue as claimed in claim 1, it is characterized in that, it is the medicament of being made by the raw material of following weight proportion: 30 parts of wolfberry fruit extracts, 10 parts of Cordyceps, 25 parts of Ganodenna Lucidum P.Es, 30 parts of tuckahoe extracts, 5 parts of Astragalus Root P.Es.
3. the health products of a kind of antifatigue as claimed in claim 1 is characterized in that, described formulation is soft capsule.
4. the health products of a kind of antifatigue as claimed in claim 1 is characterized in that, described formulation is hard shell capsules.
5. the health products of a kind of antifatigue as claimed in claim 1 is characterized in that, described formulation is tablet.
6. the health products of a kind of antifatigue as claimed in claim 1 is characterized in that, described formulation is granule.
CN2012104395082A 2012-11-02 2012-11-02 Anti-fatigue health care product Pending CN102948748A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102885313A (en) * 2012-11-05 2013-01-23 江苏江大源生态生物科技有限公司 Anti-fatigue health care product
CN103609939A (en) * 2013-11-21 2014-03-05 无限极(中国)有限公司 Astragalus polyaccharin and lycium barbarum polysaccharide composition as well as preparation method and application thereof
CN104068398A (en) * 2014-06-20 2014-10-01 广东长兴生物科技股份有限公司 Health-care product with immunity enhancing function and preparation method thereof
CN106138715A (en) * 2016-09-27 2016-11-23 杭州本草养正堂生物科技有限公司 A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue
CN106520583A (en) * 2016-12-13 2017-03-22 西华大学 Preparation method and application of microbial agent composition for enhancing secondary fermentation of bean paste
CN107334824A (en) * 2017-06-20 2017-11-10 苏州市李良济健康产业有限公司 A kind of preparation method of antifatigue health products
CN112022897A (en) * 2020-10-10 2020-12-04 邓述才 A Chinese medicinal composition for preventing cancer, and its preparation method

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125130A (en) * 1995-07-14 1996-06-26 常仲连 Health-care liquor
CN1586300A (en) * 2004-06-28 2005-03-02 陈萍 Method for preparing health food for improving immunological function
CN102100269A (en) * 2010-12-07 2011-06-22 李涛 Pure Chinese medicinal health-care tea
CN102293430A (en) * 2011-06-24 2011-12-28 于光远 Beverage with functions of antioxidation and immunity enhancing, and preparation method thereof
KR20120022134A (en) * 2010-09-01 2012-03-12 권오진 The food with overcome fatigue , using herbs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1125130A (en) * 1995-07-14 1996-06-26 常仲连 Health-care liquor
CN1586300A (en) * 2004-06-28 2005-03-02 陈萍 Method for preparing health food for improving immunological function
KR20120022134A (en) * 2010-09-01 2012-03-12 권오진 The food with overcome fatigue , using herbs
CN102100269A (en) * 2010-12-07 2011-06-22 李涛 Pure Chinese medicinal health-care tea
CN102293430A (en) * 2011-06-24 2011-12-28 于光远 Beverage with functions of antioxidation and immunity enhancing, and preparation method thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102885313A (en) * 2012-11-05 2013-01-23 江苏江大源生态生物科技有限公司 Anti-fatigue health care product
CN103609939A (en) * 2013-11-21 2014-03-05 无限极(中国)有限公司 Astragalus polyaccharin and lycium barbarum polysaccharide composition as well as preparation method and application thereof
CN103609939B (en) * 2013-11-21 2015-12-30 无限极(中国)有限公司 A kind of astragalus polyose and LBP-X composition and method of making the same and application
CN104068398A (en) * 2014-06-20 2014-10-01 广东长兴生物科技股份有限公司 Health-care product with immunity enhancing function and preparation method thereof
CN104068398B (en) * 2014-06-20 2016-08-24 广东长兴生物科技股份有限公司 A kind of health product with enhancing immunity function and preparation method thereof
CN106138715A (en) * 2016-09-27 2016-11-23 杭州本草养正堂生物科技有限公司 A kind of defying age, the compound preparation and preparation method thereof of resisting fatigue
CN106520583A (en) * 2016-12-13 2017-03-22 西华大学 Preparation method and application of microbial agent composition for enhancing secondary fermentation of bean paste
CN106520583B (en) * 2016-12-13 2019-09-03 西华大学 It is a kind of for strengthening the preparation method and application of bean cotyledon post-fermentation antimicrobial composition
CN107334824A (en) * 2017-06-20 2017-11-10 苏州市李良济健康产业有限公司 A kind of preparation method of antifatigue health products
CN112022897A (en) * 2020-10-10 2020-12-04 邓述才 A Chinese medicinal composition for preventing cancer, and its preparation method

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Application publication date: 20130306