CN101019920A - Chinese medicine composition soft capsule possessing immunopotentiation function - Google Patents
Chinese medicine composition soft capsule possessing immunopotentiation function Download PDFInfo
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- CN101019920A CN101019920A CN 200710037939 CN200710037939A CN101019920A CN 101019920 A CN101019920 A CN 101019920A CN 200710037939 CN200710037939 CN 200710037939 CN 200710037939 A CN200710037939 A CN 200710037939A CN 101019920 A CN101019920 A CN 101019920A
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Abstract
The Chinese medicine composition soft capsule possessing immunopotentiation function is prepared with astragalus root and Lentinus edodes as main material, and through water extraction of Lentinus edodes sporophore to obtain Lentinus edodes extract, water extraction of astragalus root to obtain astragalus extract, and mixing. The Chinese medicine composition has excellent synergistic effect of the effective antiviral and inflammation diminishing component in astragalus root and the effective immunopotentiation component in Lentinus edodes. It has excellent effects of preventing and treating tumor, viral myocarditis, viral hepatitis, etc.
Description
Technical field
The present invention relates to a kind of soft capsule with Chinese medicine composition of enhance immunity effect, the soft capsule of this Chinese medicine composition is in the prevention and the treatment of tumor, the valetudinarian sets upright, and has therapeutical effect at aspects such as viral myocarditis, viral hepatitis, immunologic hypofunction, chronic nephritis and renal failure, chronic bronchitiss, can be used as health product or pharmaceutical applications, belong to technical field of Chinese medicines.
Background technology
The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.vat.Mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Astragalus is a kind of draft medicinal plants of perennial, deep-rootedness, call continuous stilbene, the continuous Radix Astragali, mainly be distributed in northern area in China, generally be grown in Changbai Mountain, the Xiaoxinanlin Mountains, Wanda Mountain normal pulse Losses in Eastern Mountain Area of Liao Ning and the Daxing'an Mountainrange of the Eastern Mountain Area in northeast, the part plains region also can be seen, and provinces and regions such as Hebei, Shanxi, Shandong, the Inner Mongol, Shaanxi, Gansu, Ningxia, Qinghai, Xinjiang all have in addition, and also there are distribution in Korea, Mongolia, the Soviet Union.
The polysaccharide composition that extracts in the Radix Astragali can stimulate the T lymphocyte in-vitro multiplication of animal, thereby strengthens its specific immune function; Astragalus polysaccharides also can make the phagocytic percentage of Turnover of Mouse Peritoneal Macrophages and phagocytic index obviously raise, and shows that it can strengthen non-specific immunity in the animal body; Astragalus polysaccharides also has stronger inhibitory action to multiple virus.
Lentinus Edodes is the traditional famous edible fungi of China, artificial domesticating cultivation the earliest in the world, Lentinus Edodes is nutritious, delicious flavour, be regarded as " king in the mushroom ", contain protein 18.64% in the dried thin mushroom, fat 4.8%, in ten several amino acids that carbohydrate 71%, Lentinus Edodes contain, isoleucine is arranged, lysine, phenylalanine, methionine, threonine, the aminoacid of 7 kinds of needed by human such as valine, also contain vitamin D, B1, B2, PP and mineral salt and crude fibre etc., in the majority with hemicellulose in the carbohydrate in the Lentinus Edodes, main component is a mannitol, trehalose and bacterium sugar (mycose), glucose, pentosan, methylpentosan etc.Because the Lentinus Edodes delicious flavour is nutritious, therefore become the often edible mushroom of people.
The health care of Lentinus Edodes is worth very high:
1. it is very high to contain unsaturated fatty acid in the Lentinus Edodes, also contains the ergosterol and the fungisterol of a large amount of changed into vitamin D, for strengthening anti-disease and preventing cold and controlling preface good result is arranged;
2, often edible for want of vitamin D and the serium inorganic phosphorus that causes, rickets that the blood calcium dysbolismus causes are useful to prevention human body, particularly baby, can prevent various mucosas of human body and dermatitis disease;
3, contained Lentinus Edodes is given birth to very much (lentysin) and can be prevented sclerosis of blood vessels in the Lentinus Edodes, can reduce people's blood pressure;
4, from Lentinus Edodes, also isolate the composition (C of serum cholesterol-lowering
8H
11O
4N
5, C
9H
11O
3N
5).5, contain a large amount of potassium salt and other mineral element in the Lentinus Edodes ash, be regarded as the ultimate food that prevents that acidic food is poisoned.
Lentinus Edodes has very high medical value, as far back as 1329 China " daily draft " put down in writing the medical value of Lentinus Edodes, point out that Lentinus Edodes has the merit of " QI invigorating is not hungry, controls the wind removing blood stasis ".Japan did more research to the therapeutical effect of Lentinus Edodes afterwards, proposed the growth that Lentinus Edodes can help child's skeleton and tooth, and control baby rickets promotes the health normal development.In the middle period 70 year last century, scientific and technological circle have set foot on the track that lentinan is carried out modern scientific research.According to Dehoratius, hepatitis B patient has the T cell to reduce, the phenomenon that its conversion ratio reduces.After the lentinan treatment, these phenomenons can be improved.(Ishimura etc.) find that the earliest lentinan can suppress the growth of tumor S-180 fully, and finding has plasma cell and macrophage to assemble around the tumor kitchen range, illustrate but tumor and immunologically competent cell are closely related.These data prove that tentatively lentinan has the raising immunologic function, and play tumor-inhibiting action by this function.Prove by experiment also during this that lentinan can promote glucose glycogen biosynthesis in the blood, blood sugar lowering is not only treated diabetes but also is protected the liver.
Modern study shows, contained lentinan and double stranded RNA in the Lentinus Edodes extract has stronger anti-cancer and cancer-preventing effect, is applicable to the food therapy of the multiple malignant tumor that comprises leukemia.Because of its disease and even liver cirrhosis etc. dietetic therapy and preventive effect are arranged also in addition.
In summary, the Radix Astragali and Lentinus Edodes have been brought into play powerful effectiveness as two kinds of important medicines in using separately.But both compatibilities are used, bring into play the complementary action of both different mechanism of action, thereby the medicine that plays stronger immunological enhancement does not appear in the newspapers as yet.
Summary of the invention
The purpose of this invention is to provide a kind of soft capsule with Chinese medicine composition of immunological enhancement, its simultaneously can play therapeutical effect at aspects such as setting upright of the prevention of tumor and treatment, viral myocarditis, viral hepatitis, immunologic hypofunction, chronic nephritis and renal failure, chronic bronchitis, valetudinarian.
For realizing above purpose, technical scheme of the present invention provides a kind of Chinese medicine composition composition soft capsule with enhance immunity effect, it is characterized in that, is made by the raw material of following weight portion: 1～40 part of the Radix Astragali, and 1～10 part on Lentinus Edodes,
Its preparation method is:
(1) gets mushroom fruiting body, pulverize, throw to extracting still, add 15 ~ 20 times water of Lentinus Edodes weight, boil, constant temperature 2 hours-6 hours, repeat to extract below 6 times, the gained extracting solution merges concentrated, is concentrated into 3 ~ 4 times of Lentinus Edodes weight, the medicinal alcohol that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature, continue to stir 20 hours-40 minutes, after static 10 hours-14 hours, separation of supernatant reclaims ethanol, after the precipitation material is centrifugal, again after 1-3 doubly measures centrifugal material volume of ethanol washing, carry out again centrifugal, centrifugal material vacuum drying, baking temperature is 50 ℃-80 ℃, discharging after 20 hours-26 hours, dry thing pulverizing 60 ~ 100 orders/time, promptly get the Lentinus Edodes water extract;
(2) get Radix Astragali section, add astragalus weight 5-6 water doubly, boil, constant temperature 2 hours-5 hours stops heating, cooling, discharging, liquid-solid separation repeats to extract below 5 times, and the gained extracting solution merges concentrated, be concentrated into astragalus weight 1.5-2 doubly, the medicinal alcohol that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature, precipitation is after static 6-10 hour, liquid-solid separation, supernatant send ethanol to reclaim, the precipitation material again after 1-3 doubly measures centrifugal material volume of ethanol washing 1-3 time, vacuum drying, baking temperature is 50 ℃-80 ℃, discharging after 20 hours-26 hours, dry thing pulverizing 60 ~ 100 orders/time, promptly get Radix Astragali extract A;
(3) get Radix Astragali residue behind the step Radix Astragali water extraction, after adding sodium hydroxide solution with 10% concentration of volume and soaking 8 hours-24 hours, Radix Astragali residue is abandoned it, sodium hydroxide extraction liquid transfers pH to neutral with hydrochloric acid, to tap water dialysis 48 hours-72 hours, dialysis solution concentrates, and is concentrated into 1/2 of astragalus weight, the medicinal alcohol precipitation that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature, centrifugal, after static 6 hours-10 hours, liquid-solid separation, centrifugal thing after 1-3 doubly measures volume of ethanol washing, vacuum drying, baking temperature is 50 ℃-80 ℃, in 60-100 order/time, pulverized in discharging after 20 hours-26 hours, dry thing, promptly gets Radix Astragali extract B;
(4) Radix Astragali water extract is pulverized material A and Radix Astragali alkaline extraction thing and pulverized material B mixing;
(5). get the Radix Astragali water extract that is equivalent to 1～40 part of the Radix Astragali and pulverize material A and Radix Astragali alkaline extraction thing pulverizing material B mixture, be equivalent to the Lentinus Edodes extract of Lentinus Edodes 1-10 part, make aqueous implant, fill, promptly get soft capsule of the present invention with soybean oil 20-40 part.
Chinese medicine composition provided by the invention can be brought into play more powerful collaborative immunological enhancement after making the effective ingredient of enhance immunity effect in the Radix Astragali and Lentinus Edodes combination of active principles; Can also better bring into play effect such as effective extract antiviral and antiinflammatory in the Radix Astragali.
The natural constituent that the present invention extracts from plant, purity height, healthy nutritive value are big, and for oiliness or oiliness and powdery suspension material, soft capsule is its optimum dosage form.The present invention has made full use of the advantage of this dosage form of soft capsule, the soft capsule packing has the good isolation function, can will keep apart functional material and air, the light of light, oxygen sensitivity, avoids the oxidation of active substance, make product keep stable content before the deadline, guarantee the performance of effect.Secondly, soft capsule is quantitatively accurate, absorbs fast.By the soft capsule of machine quantitative filling, dose error is little, and the each amount of eating of consumer is stablized.After the disintegrate, content can be absorbed by health with the form of liquid state soft capsule very soon in vivo.Soft capsule product appearance novelty, tempting once more, smooth surface, mouthfeel is good, easily swallows, to the very attractive and novel sense of consumer.
Advantage of the present invention is to have simultaneously at aspects such as setting upright of the prevention of tumor and treatment, viral myocarditis, viral hepatitis, immunologic hypofunction, chronic nephritis and renal failure, chronic bronchitis, valetudinarian to play possesses synergistic, and is easy to use.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
(1). get clean mushroom fruiting body, be ground into the fritter grain of 1 * 1cm.Through tap water flushing dust, throw to extracting still.The water that adds 20 times of amounts of Lentinus Edodes weight heats up and is heated to 100 ℃ of extractions, extracts after 4 hours to stop.Be cooled to room temperature, discharging, liquid-solid separation, clear liquid is delivered to concentrated post and is concentrated into 3 ~ 4 times of Lentinus Edodes weight, filtering residue adds the water of 15 times of amounts again, repeat the said extracted condition and extract, repeat altogether to extract 4 times, filtering residue is abandoned it, supernatant merges 4 times of volume concentrated solutions that are concentrated into mushroom fruiting body weight, at room temperature, under the stirring condition, slowly add 3 times of amount medicinal alcohols of concentrated solution volume, continue to stir 30 minutes, after static 12 hours, separation of supernatant reclaims ethanol, after the precipitation material is centrifugal, add 2 times of amount medicinal alcohols, blend washing, carry out again centrifugal after, 60 ℃ of vacuum dryings of centrifugal material, discharging, pulverize, with 60 orders/time sub-sieve sieve, promptly get Lentinus Edodes extract after the weighing;
(2). the Radix Astragali of the section of learning from else's experience adds the water of 6 times of amounts, is warming up to and boils, and makes the water extraction of Radix Astragali extract.Behind the constant temperature 3 hours, stop heating, cooling, discharging, liquid-solid separation, Radix Astragali material slag adds the water of 5 times of amounts again, repeats to extract 2 times, three times extracting solution merges, be concentrated into 1.5 times of amount volumes of Radix Astragali inventory, be cooled to room temperature, under stirring condition, the medicinal alcohol that slowly adds 3 times of volumes of concentrated solution, precipitation finishes, and stops to stir, after static 8 hours, liquid-solid separation, supernatant send ethanol to reclaim, the medicinal alcohol washing of 2 times of volumes of precipitation material reuse precipitation material, separate, repeat 2 times of amount washing with alcohol more once, washing back filtrate is delivered to 60 ℃ of vacuum dryings of vacuum drying oven, after 24 hours dried Radix Astragali extract through pulverizer pulverize 60 orders/time sub-sieve sieve, get Radix Astragali water extract and pulverize material, yield is 3.2%;
(3). the Radix Astragali filtering residue after water is carried adds 10% sodium hydroxide solution with volume, soak after 24 hours, liquid-solid separation, Radix Astragali residue is abandoned it, sodium hydroxide extraction liquid is regulated pH to neutral with 3mol/L hydrochloric acid, after the every 500ml bundle of neutralizer bag filter was dialysed＞48 hours to tap water, the concentrate dialysate volume is the Radix Astragali 1/2 of the weight that feeds intake, and under stirring condition, slowly adds the medicinal alcohols of 3 times of amounts of concentrate dialysate volume, precipitation, after static 8 hours, liquid-solid separation adds the medicinal alcohol washing of 2 times of precipitation material volumes, filtrate is delivered to 60 ℃ of vacuum dryings of vacuum drying oven behind separating, washing, after 24 hours dried Radix Astragali extract, pulverize through pulverizer, 60 orders/time sub-sieve sieve, get Radix Astragali alkaline extraction thing and pulverize material, yield is 1.4%.
(4) Radix Astragali water extract is pulverized material A and Radix Astragali alkaline extraction thing and pulverized material B mixing;
(5) get the Radix Astragali water extract that is equivalent to 20 parts of the Radixs Astragali and pulverize material A and Radix Astragali alkaline extraction thing pulverizing material B mixture, be equivalent to the Lentinus Edodes extract of 5 parts on Lentinus Edodes, make aqueous implant for 15 parts, fill, promptly get soft capsule of the present invention with soybean oil.
Utilize Chinese medicine composition of the present invention to carry out pharmacological evaluation to verify its drug effect.
1. tumor suppression test: get 4～5 age in week Kunming mouse, body weight 20 ± 5g, the male and female dual-purpose, random packet, 15 every group, with S
180It is 5 * 10 that tumor liquid is diluted to cell concentration with normal saline
6The cell suspension of/0.2ml, ip injects.Irritate stomach respectively and give Radix Astragali extract (0.6g/kg), the Lentinus Edodes extract (0.6g/kg) and the present composition (0.6g/kg).Once a day, two weeks of logotype.Observe of the influence of three kinds of medicines to the tumor-bearing mice life span.The result shows that the life span of soft capsule group of the present invention obviously is longer than the life span of said composition Capsules group.
The soft capsule of the present composition is to the influence of tumor-bearing mice life span
| The animal grouping | Mean survival time (n=15) |
| The said composition Capsules group | 20.0 my god |
| Soft capsule group of the present invention | 25.0 my god |
2. lymphocyte proliferation assay: with soft capsule of the present invention is experimental drug, is contrast with the said composition Capsules group.The aseptic dirty peripheral blood of Cor Gigeriae Galli, the anticoagulant heparin adopted.Percoll cell layering liquid isolated lymphocytes.The lymphocyte for preparing joins 96 porocyte culture plates, and 50 μ L/ holes add medicine 0.1g to be measured then, and respectively as T, bone-marrow-derived lymphocyte mitogen, concentration is respectively 45,22.5 μ g/ml with concanavalin A, bacteria lipopolysaccharide.Each handles 3 multiple holes, puts 40 ℃, 5%CO
2After cultivating 60h under the condition, Brdu-ELISA test kit (Bioehringer Mannheim company) labelling, colour developing are measured OD with 318～MC microplate reader
450nmValue.Data are added up with SPSS software.The result is as follows:
| Medicine | OD 450nmValue (X ± SD) | |
| The T lymphocyte | Bone-marrow-derived lymphocyte | |
| Soft capsule group of the present invention | 0.647±0.143** | 1.242±0.114** |
| The said composition Capsules group | 0.567±0.113* | 0.946±0.152* |
| Blank | 0.424±0.028 | 0.796±0.131 |
*P＜0.05，**P＜0.01
The result shows that soft capsule group of the present invention obviously is better than the said composition Capsules group to the facilitation that the inductive chicken T of concanavalin A lymphopoiesis reaches the inductive chicken B lymphocyte propagation of bacteria lipopolysaccharide.Below by the result of one group of small clinical trials, promptly a step is set forth beneficial effect of the present invention:
One, physical data adopts capsule of the present invention, the patient of treatment from seven years old to eight teen ages.All prove cancer through clinical means such as CT examination, section, chemical examinations.Routine gastric cancer, esophageal carcinoma case are added up surplus now collecting 30.
Two, Therapeutic Method is taken medicine 3 times every day, and 20 days is a course of treatment;
Three, efficacy assessment standard adopts self treatment front and back symptom contrast;
The positive symptom of clinical cure symptom and inspection disappears, and diet, spirit, blood pressure, cell ratio recover, and recover certain work capacity:
The produce effects symptom disappears substantially, and focus is dwindled, and every index of physical examination takes a turn for the better;
Effectively symptom makes moderate progress, and focus is basicly stable;
Invalid symptom does not change or worsens;
Through observing, took medicine back 3～7 days, the symptom of most patients, obviously alleviate or disappear as edema, anorexia, dysphagia, vomiting, pain etc., spirit takes a turn for the better, appetite increases, and blood pressure, blood equate that index improves, reach can 97% for the doing well,improving rate in 15 days, take 2～3 courses of treatment, observe the tumor body and dwindle, tumour inhibiting rate is more than 40～50%.Total effective rate is 97% by statistics.
Claims (1)
1. the soft capsule with Chinese medicine composition of enhance immunity effect is characterized in that, is made by the raw material of following weight portion: Radix Astragali 1-40 part, and Lentinus Edodes 1-10 part,
Its preparation method is:
(1). get mushroom fruiting body, pulverize, throw to extracting still, add the 15-20 water doubly of Lentinus Edodes weight, boil extraction, constant temperature stops after 2 hours-6 hours extracting, be cooled to room temperature, discharging, liquid-solid separation, clear liquid is delivered to concentrated post and is concentrated into 3 ~ 4 times of Lentinus Edodes weight, filtering residue adds the water that 10-20 doubly measures, and repeats the said extracted condition and extracts below 6 times, and filtering residue is abandoned it, the supernatant merging is concentrated into 3 ~ 4 times of Lentinus Edodes weight, the medicinal alcohol that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature continues to stir 20 minutes-40 minutes, after static 10 hours-14 hours, separation of supernatant, reclaim ethanol, after the precipitation material is centrifugal, again after 1-3 doubly measures the washing of centrifugal material volume of ethanol, carry out again centrifugal after, centrifugal material vacuum drying, baking temperature are 50 ℃-80 ℃, discharging after 20 hours-26 hours, dry thing is pulverized 60-100 order/time, promptly gets the Lentinus Edodes water extract;
(2). get Radix Astragali section, add astragalus weight 5-6 water doubly, boil, make the water extraction of Radix Astragali extract, constant temperature 2 hours-5 hours, stop heating, cooling, discharging, liquid-solid separation, repeat to extract below 5 times, the gained extracting solution merges concentrated, is concentrated into astragalus weight 1.5-2 doubly, the medicinal alcohol that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature, precipitation, after static 6 hours-10 hours, liquid-solid separation, supernatant send ethanol to reclaim, precipitation material is again after 1-3 doubly measures centrifugal material volume of ethanol washing 1-3 time, vacuum drying, baking temperature are 50 ℃-80 ℃, discharging after 20 hours-26 hours, dry thing through pulverizer pulverize 60 ~ 10 orders/time, promptly get Radix Astragali water extract and pulverize and expect A;
(3). get the Radix Astragali residue behind step 2 Radix Astragali water extraction, after adding sodium hydroxide solution with 10% concentration of volume and soaking 8 hours-24 hours, liquid-solid separation, Radix Astragali residue is abandoned it, sodium hydroxide extraction liquid transfers pH to neutral with hydrochloric acid, neutralizer is pricked bag filter to tap water dialysis 48 hours-72 hours, dialysis solution concentrates, be concentrated into 1/2 of astragalus weight, the medicinal alcohol precipitation that the 2-4 of adding concentrated solution volume doubly measures under stirring at normal temperature, after static 6 hours-10 hours, liquid-solid separation, after centrifugal thing is doubly measured the medicinal alcohol washing of volume through 1-3, filtrate is delivered to the vacuum drying oven vacuum drying behind separating, washing, and baking temperature is 50 ℃-80 ℃, discharging after 20 hours-26 hours, dry thing is pulverized 60-100 order/time, promptly gets Radix Astragali alkaline extraction thing and pulverizes material B;
(4) Radix Astragali water extract is pulverized material A and Radix Astragali alkaline extraction thing and pulverized material B mixing;
(5) get the Radix Astragali water extract that is equivalent to 1～40 part of the Radix Astragali and pulverize material A and Radix Astragali alkaline extraction thing pulverizing material B mixture, be equivalent to the Lentinus Edodes extract of Lentinus Edodes 1-10 part, make aqueous implant for 15 parts, fill, promptly get soft capsule of the present invention with soybean oil.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710037939 CN101019920A (en) | 2007-03-09 | 2007-03-09 | Chinese medicine composition soft capsule possessing immunopotentiation function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710037939 CN101019920A (en) | 2007-03-09 | 2007-03-09 | Chinese medicine composition soft capsule possessing immunopotentiation function |
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| CN101019920A true CN101019920A (en) | 2007-08-22 |
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| CN 200710037939 Pending CN101019920A (en) | 2007-03-09 | 2007-03-09 | Chinese medicine composition soft capsule possessing immunopotentiation function |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309538A (en) * | 2015-06-26 | 2017-01-11 | 威海松龄诺可佳中药饮片有限公司 | MACA polysaccharide composition, preparation method and application thereof |
| WO2019024015A1 (en) * | 2017-08-02 | 2019-02-07 | 江苏安惠生物科技有限公司 | Stomach strengthening health-care capsule for enhancing immunity |
-
2007
- 2007-03-09 CN CN 200710037939 patent/CN101019920A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309538A (en) * | 2015-06-26 | 2017-01-11 | 威海松龄诺可佳中药饮片有限公司 | MACA polysaccharide composition, preparation method and application thereof |
| WO2019024015A1 (en) * | 2017-08-02 | 2019-02-07 | 江苏安惠生物科技有限公司 | Stomach strengthening health-care capsule for enhancing immunity |
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