CN108543036A - A kind of antitumor drug and preparation method thereof - Google Patents
A kind of antitumor drug and preparation method thereof Download PDFInfo
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- CN108543036A CN108543036A CN201810222361.9A CN201810222361A CN108543036A CN 108543036 A CN108543036 A CN 108543036A CN 201810222361 A CN201810222361 A CN 201810222361A CN 108543036 A CN108543036 A CN 108543036A
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- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of antitumor drugs and preparation method thereof, include the ingredient of following parts by weight：5 10 parts of camplotheca acuminata, 15 20 parts of Radix Glycyrrhizae, 8 16 parts of ganoderma lucidum, 8 14 parts of Hedyotidis Diffusae, 12 18 parts of curcuma zedoary, 15 20 parts of ginseng.The present invention meets Chinese medical discrimination theory in Chinese medicine selection and compatibility, and therapeutic effect is notable, and has no toxic side effect, and has reached complementary purpose in drug matching.Compatibility of the present invention is reasonable, and administration is simple, conveniently, and the present invention being capable of effectively immunosupress, antitumor.Chinese medicine composition of the present invention have effects that safely and effectively, improve immunity, be used for the treatment of tumour, curative for effect, stable dosage forms are quality controllable and have no toxic side effect.
Description
Technical field
The present invention relates to antitumor drug technical field, specially a kind of antitumor drug and preparation method thereof.
Background technology
Tumour is to seriously threaten one of human health and the major disease of social development, and threaten China resident strong at present
The major disease of health.Clinically common chemicotherapy method treatment tumour also results in machine while killing tumor cell at present
Body bone marrow suppression and immunologic hypofunction, toxic side effect are big.Therefore high-efficiency low-toxicity is found from natural animal, plant and mineral
Antitumor drug or active constituent be recent domestic scholar research hot spot.Traditional Chinese medicine is the distinctive traditional medicine in China
Treasure-house provides the money of very abundant for the research and development of anticancer drug in the history that China is used to prevent and cure diseases existing more than 2000 years
Source.Therefore, it is badly in need of developing more effective antitumor drug.
Invention content
In order to solve the above technical problems, a kind of antitumor drug of present invention offer and preparation method thereof.
It is an object of the present invention to provide a kind of antitumor drugs, include the ingredient of following parts by weight：Camplotheca acuminata 5-10
Part, 15-20 parts of Radix Glycyrrhizae, 8-16 parts of ganoderma lucidum, 8-14 parts of Hedyotidis Diffusae, 12-18 parts of curcuma zedoary, 15-20 parts of ginseng.
Further, include the ingredient of following parts by weight：Include the ingredient of following parts by weight：8-10 parts of camplotheca acuminata, Radix Glycyrrhizae 18-
20 parts, 10-16 parts of ganoderma lucidum, 10-14 parts of Hedyotidis Diffusae, 15-18 parts of curcuma zedoary, 18-20 parts of ginseng.
Further, include the ingredient of following parts by weight：5-8 parts of camplotheca acuminata, 15-18 parts of Radix Glycyrrhizae, 8-14 parts of ganoderma lucidum, long-noded pit viper
8-13 parts careless, 12-15 parts of curcuma zedoary, 15-18 parts of ginseng.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, filter
It crosses, collecting decoction, concentrates, ointment is made；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese medicine
Composition.
Further, first time decocting time 2-4 hours, second decocting time 1-2 hours.
Further, in S1, collecting decoction is concentrated into density=1.2g/ml.
Raw material involved by the Chinese medicinal ointment of the present invention has following effect：
Camplotheca acuminata：Bitter；It is pungent；It is cold in nature；It is toxic, returns spleen；Stomach and liver passes through, clearing heat and detoxicating；Dispersing accumulated pathogens to resolve the mass, heat-clearing and detoxifying drug；Dissipating bind
Xiao Disorder medicines, cure mainly cancer of the esophagus；Cardia cancer；Gastric cancer；Intestinal cancer；Liver cancer；Leukaemia；Psoriasis；Sore swells.
Radix Glycyrrhizae：It is sweet；It is flat, spleen；Stomach；The heart；Lung channel, invigorating middle warmer and replenishing QI；Relieving spasm to stop pain；It moistens the lung and relieve the cough；Purging intense heat and detonicating；It reconciles all
Medicine, tonic；The lung moistening medicine cures mainly burnout deficiency of food；The thin face of flesh is yellow；Palpitation；Abdominal pain loose stool；Four limbs contraction；Hysteria；Cough
It coughs asthma；Abscess of throat；Ulcerative carbuncle swells and ache；Infant fetal toxin；And drug, food poisoning.
Ganoderma lucidum：Containing substances such as ganoderma lucidum polysaccharide, triterpene, organic germaniums, the phagocytosis of macrophage can be promoted, improve T leaching
Bar cell and the activity of cell and the conversion ratio of lymphocyte are killed, promotes the formation of immunoglobulin, enhance body constitution.Spirit
The substances such as polysaccharide, triterpene, the organic germanium of sesame can penetrate into cancer cell with telomere covalent bond, so that enzyme molecule is elongated denaturation, break
The telomerase activation of bad cancer cell, makes cancer cell-apoptosis.Ganoderma lucidum polysaccharide stimulates human body non-specific antibody to generate, and can promote macrophage
The phagocytosis of cell improves the activity of T cell and NK cells, improves the conversion ratio of lymphocyte, increasing leukocyte, so clever
Sesame, which has, promotes immunoglobulin to be formed, and improves the effect of body independently presses down cancer ability.
Oldenlandia diffusa：Enhance immune function, influence the activity of the related enzyme of energetic supersession in cancer cell, induces cancer cell
Apoptosis, fracture cancer cell DNA.The ingredients such as polyphenol, flavones, organic acid that oldenlandia diffusa contains, which have, changes oxidation state or enol
The chemical feature of formula and keto-acid functional group interconversion's isomery, oxygen radical that can be excessive in scavenger-cell, and enhance other anti-oxidant
Enzymatic activity, to play anti oxidative damage.
Curcuma zedoary：Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong.For Dan lump in the abdomen lump in the abdomens, blood stasis closed, dyspepsia distending pain；Early cervical carcinoma.
Ginseng：Its is warm-natured, sweet and slightly bitter taste, returns spleen, lung, the heart channel of Hang-Shaoyin.Function is to reinforce vital energy, and veins takes off admittedly reinforces the spleen to benefit the lung, raw
Tianjin is calmed the nerves；Tonifying five zang organs are adjusted, arteries and veins is proficient in by force, promotes longevity.It can be used to treat lung cancer, liver cancer, gastric cancer, leukaemia and other evils
Property tumour.Ginseng can assist the effect of monarch drug in a prescription strengthening vital QI to eliminate pathogenic factors, ministerial drug in the side of being.Clinical verification, ginseng to kinds cancer, have compared with
Good curative effect, and without toxic, side effects, can use in right amount.The medical value of ginseng has been described.For example,《Pharmacological property book on Chinese herbal medicine》It points out,
" the main general debility of ginseng, deficient abundant expectoration, cough-relieving are vomited, tonifying five zang organs six internal organs, post god in guarantor, disappear phlegm in the heart, controls lung fistula and dysentery, cold
The circulation of vital energy in the wrong direction is stopped.The not lower food of typhoid fever, all empty and dreaminess is diverse and confused ".《Pearl sac》It points out, " (ginseng) controls lung, stomach YANG QI deficiency, Lung Qi deficiency
Promote, few gas of losing heart, during bowl spares is slow, removing the heart-fire, lung, spleen, stomach fire are evil, can quench the thirst, born fluid ".《Traditional Chinese and western medicine Clinical Oncology》It points out,
" panaxoside has stronger antitumor action, includes the direct killing to tumour cell, and mainly relies in adjustment immunity of organism
The double action ... of system killing tumor cell has adaptive significances, can increase non-spy of the body to a variety of adverse factors
Anisotropic resistance；There is resistant function to many harmful effects of physics, chemistry, biology, such as transplantable tumor；Improve the adaptation of body
Property, have and pathologic process is promoted to restore normal function.
The beneficial effects of the invention are as follows：
A kind of antitumor drug of the present invention and preparation method thereof meets Chinese medical discrimination reason in Chinese medicine selection and compatibility
By therapeutic effect is notable, and has no toxic side effect, and has reached complementary purpose in drug matching.Compatibility of the present invention is reasonable, gives
Medicine is simple, conveniently, and the present invention being capable of effectively immunosupress, antitumor.There is Chinese medicine composition of the present invention safe and effective, raising to exempt from
The effect of epidemic disease power, it to be used for the treatment of tumour, curative for effect, stable dosage forms are quality controllable and have no toxic side effect.
Specific implementation mode
Below in conjunction with the specific embodiment of the invention, technical scheme of the present invention is clearly and completely described, is shown
So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention
Example is applied, every other embodiment obtained by those of ordinary skill in the art without making creative efforts all belongs to
In the scope of protection of the invention.
Embodiment 1
A kind of antitumor drug includes the ingredient of following parts by weight：5 parts of camplotheca acuminata, 15 parts of Radix Glycyrrhizae, 8 parts of ganoderma lucidum, Hedyotidis Diffusae
8 parts, 12 parts of curcuma zedoary, 15 parts of ginseng.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, the
Decocting time 2 hours, second decocting time 1 hour, filtration, collecting decoction is concentrated into density=1.2g/ml, is made
Ointment；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese medicine
Composition.
Embodiment 2
A kind of antitumor drug includes the ingredient of following parts by weight：Include the ingredient of following parts by weight：8 parts of camplotheca acuminata, Radix Glycyrrhizae
18 parts, 10 parts of ganoderma lucidum, 10 parts of Hedyotidis Diffusae, 15 parts of curcuma zedoary, 18 parts of ginseng.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, the
Decocting time 3 hours, second decocting time 1.5 hours, filtration, collecting decoction is concentrated into density=1.2g/ml, makes
Obtain ointment；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese medicine
Composition.
Embodiment 3
A kind of antitumor drug includes the ingredient of following parts by weight：8 parts of camplotheca acuminata, 18 parts of Radix Glycyrrhizae, 14 parts of ganoderma lucidum, long-noded pit viper
13 parts of grass, 15 parts of curcuma zedoary, 18 parts of ginseng.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, the
Decocting time 4 hours, second decocting time 2 hours, filtration, collecting decoction is concentrated into density=1.2g/ml, is made
Ointment；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese medicine
Composition.
Embodiment 4
A kind of antitumor drug includes the ingredient of following parts by weight：10 parts of camplotheca acuminata, 20 parts of Radix Glycyrrhizae, 16 parts of ganoderma lucidum, long-noded pit viper
14 parts of grass, 18 parts of curcuma zedoary, 20 parts of ginseng.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, the
Decocting time 4 hours, second decocting time 2 hours, filtration, collecting decoction is concentrated into density=1.2g/ml, is made
Ointment；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese medicine
Composition.
Embodiment 5
Clinical data：
Selection is diagnosed as tumor patient 230, is randomly divided into treatment group 130 and control group 100.Wherein, treatment group
Male 55, women 75, the age, average age was 48 years old between 40~60 years old, and the course of disease is 3 years, average course of disease 1.5
Year；Control group male 46, women 54, the age, average age was 42 years old between 38~55 years old, and the course of disease is 3 years, average disease
Journey is 1 year.Two groups of Genders, age, course of disease no significant difference (P ＞ 0.05).Treatment group gives Chinese medicine composition of the present invention
It is treated together with chemotherapy, one day 5g；Control group only does chemotherapy.Two groups are 6 months as a treatment course.Treatment group 130 cures 60
Example (46.15%), it is effective 42 (32.31%), it improves 15 (11.54%), invalid 13 (10%), total effective rate 90%；
Control group 100 is cured 25 (25%), effective 32 (32%), is improved 19 (19%), invalid 24 (24%), is always had
Efficiency 76%, two groups of cure rates and total effective rate difference are significant (P ＜ 0.01 or 0.05).Treatment group does not occur any bad
Reaction, control group have 27 patients bareheaded, lassitude occur and switch to Chinese medicine treatment.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (6)
1. a kind of antitumor drug, which is characterized in that include the ingredient of following parts by weight：5-10 parts of camplotheca acuminata, 15-20 parts of Radix Glycyrrhizae,
8-16 parts of ganoderma lucidum, 8-14 parts of Hedyotidis Diffusae, 12-18 parts of curcuma zedoary, 15-20 parts of ginseng.
2. a kind of antitumor drug according to claim 1, which is characterized in that include the ingredient of following parts by weight：Including
The ingredient of following parts by weight：8-10 parts of camplotheca acuminata, 18-20 parts of Radix Glycyrrhizae, 10-16 parts of ganoderma lucidum, 10-14 parts of Hedyotidis Diffusae, curcuma zedoary 15-18
Part, 18-20 parts of ginseng.
3. a kind of antitumor drug according to claim 1, which is characterized in that include the ingredient of following parts by weight：Camplotheca acuminata
5-8 parts, 15-18 parts of Radix Glycyrrhizae, 8-14 parts of ganoderma lucidum, 8-13 parts of Hedyotidis Diffusae, 12-15 parts of curcuma zedoary, 15-18 parts of ginseng.
4. according to a kind of preparation method of any antitumor drugs of claim 1-3, which is characterized in that including walking as follows
Suddenly：
S1：Camplotheca acuminata, Radix Glycyrrhizae, ganoderma lucidum, Hedyotidis Diffusae, curcuma zedoary, ginseng are weighed respectively, selects wash clean, are added water to cook twice, filtration,
Ointment is made in collecting decoction, concentration；
S2：50g ointment sugaring powder is taken to go out grain, it is dry, screening grain is crossed, conforming particle is obtained, is dispensed, is entered bag, obtain Chinese traditional medicine composition
Object.
5. a kind of preparation method of antitumor drug according to claim 4, which is characterized in that first time decocting time 2-
4 hours, second decocting time 1-2 hours.
6. a kind of preparation method of antitumor drug according to claim 4, which is characterized in that in S1, collecting decoction is dense
It is reduced to density=1.2g/ml.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111420007A (en) * | 2019-12-31 | 2020-07-17 | 刘桂沅 | Multi-target cancer cell killing granule and preparation process thereof |
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|---|---|---|---|---|
| CN1337251A (en) * | 2001-07-13 | 2002-02-27 | 何利均 | Anticancer capsule |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1337251A (en) * | 2001-07-13 | 2002-02-27 | 何利均 | Anticancer capsule |
Non-Patent Citations (2)
| Title |
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| 施汀兰等: "中药抗肿瘤作用研究概况", 《重庆中草药研究》 * |
| 杜建: "中药抗肿瘤机制研究进展", 《福建中医学院学报》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111420007A (en) * | 2019-12-31 | 2020-07-17 | 刘桂沅 | Multi-target cancer cell killing granule and preparation process thereof |
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