CN104127684A - Traditional Chinese medicine compound preparation for treating cancers - Google Patents
Traditional Chinese medicine compound preparation for treating cancers Download PDFInfo
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- CN104127684A CN104127684A CN201410405019.4A CN201410405019A CN104127684A CN 104127684 A CN104127684 A CN 104127684A CN 201410405019 A CN201410405019 A CN 201410405019A CN 104127684 A CN104127684 A CN 104127684A
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Abstract
The invention provides a traditional Chinese medicine compound preparation for treating cancers. The preparation is prepared from the following raw medicinal materials in parts by weight: 110-130 parts of curcumin, 10-30 parts of subprostrate sophora extracts, 30-50 parts of sealwort extracts, 10-30 parts of fructus forsythiae extracts, 10-30 parts of radix bupleuri extracts, 10-30 parts of ligusticum wallichii extracts and 10-30 parts of pinellia ternate extracts. The preparation provided by the invention is high in curative effect, low in cost, convenient and efficient to use, free from toxic and side effects and high in patient compliance.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation for the treatment of cancer.
Background technology
Cancer is the general designation of a large class malignant tumor.The feature of cancerous cell be unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, makes human body produce series of symptoms; Cancerous cell also can be transferred to whole body growth and breeding everywhere, cause that human body is become thin, unable, anemia, inappetence, heating and serious organ function impaired etc.On the other side have a benign tumor, benign tumor is easily removed clean, generally do not shift, do not recur, organ, tissue are only had to extruding and blocking action, but cancer (malignant tumor) also can disorganize, the 26S Proteasome Structure and Function of organ, cause downright bad hemorrhage concurrent infection, patient is finally dead due to organ failure.
At present, doctor trained in Western medicine has for the Therapeutic Method of cancer: operative treatment, radiotherapy and Drug therapy.Wherein operative treatment has good curative effect to early stage patient, but its medical expense costliness, and not good to patients with terminal therapeutic effect, also has some patients can not carry out operative treatment because of health reason, as patient has serious cardiopulmonary or hepatic and kidney function obstacle.Radiocurable indication is wider, but it can follow serious untoward reaction and the complication such as hemorrhage, perforation and radiation myelopathy.Although it is many to treat in addition the medicine kind of cancer, mostly expensive and poor effect, some medicines, dosage is large, kind is many, and not only effect is bad, but also can bring many side effect, produces adverse consequences.Method and the medicine for the treatment of cancer are numerous, spread and improved patient's body constitution and improve the specific medicament of life quality but there is no so far treatment cancer, particularly having improved life cycle for patient with advanced cancer and Chinese medicine preparation life quality, that toxic and side effects is less there is no.
The cancer traditional Chinese medical science is called and is gathered and so on, long-pending person, long-pending base, stagnant: to gather the meaning that has knot poly-, long-pendingly hard do not move, it produces the cause of disease seven: one, and pathogenic cold injuring blood is solidifying: the 2nd, and dyspepsia venation: the 3rd, QI rising in reverse order blood clotting: the 4th, wind impairment of ZANG FU-organs: the 5th, stagnant one-tenth of a specified duration is long-pending: the 6th, it is long-pending that the stagnation of QI becomes: the 7th, weakened body resistance one-tenth is long-pending: the 8th, five kinds of over strain is raw long-pending: that gathers controls, Jing-Yue Complete Works is loaded with attacks, disappear, loose, mend four methods, all long-pending hard QI excess persons, non-attacking can not be gone, can't bear assailant, only should food stagnation removing gradually grind, aeolian accumulation painful abdominal mass gesture is slow and attack benefit and all have inconvenient person, when many function of spleen and stomach regulating are main to fall apart it, if taste two lose, healthy energy extreme deficiency syndrome person, the method that specially should make corrections is to delay its heresy of dispelling.
The present invention follows theory of Chinese medical science and a kind of new compound Chinese medicinal preparation developed just, cancer becomes incurable disease at present, people talk cancer complexion changed, the method that is exactly treatment is improper, it is all treating the poisonous disease with poisonous drugs, manage to kill cancerous cell, its result cancerous cell does not kill, and makes patient's immunity reduce cancerous cell expanding and injured human normal cell.Every patient who checks out cancer, mostly " healthy energy extreme deficiency syndrome ".Its result for the treatment of the poisonous disease with poisonous drugs causes the more empty vital qi of human body to die.The present invention adopts the way to keep in good health of Zhang Jingyue tonifying both YIN and YANG, and medical material safety non-toxic used, carries and selecting the essence through modern processing technique again, mends its vital qi to transfer patient self antioncogene, reaches the object of thorough healing cancer.
Summary of the invention
Object of the present invention provides a kind of compound Chinese medicinal preparation for the treatment of cancer, and curative effect of the present invention is high, cheap, easy to use simple and direct, has no side effect, and patient compliance is high.
Treat a compound Chinese medicinal preparation for cancer, made by weight by following bulk drugs:
Curcumin 110-130 part, Radix Sophorae Tonkinensis extract 10-30 part, Rhizoma Polygonati extract 30-50 part, Fructus Forsythiae extract 10-30 part, Radix Bupleuri extract 10-30 part, Rhizoma Chuanxiong extract 10-30 part, Rhizoma Pinelliae extract 10-30 part.
The preparation method of above-mentioned compound Chinese medicinal preparation is:
1. the preparation of extract
(1) preparation method of Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Fructus Forsythiae, Radix Bupleuri extract
Each medical material adds respectively 35% alcohol reflux 3 times, 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount is followed successively by 7 times, 6 times, 4 times, and merge extractive liquid, filters, reclaim ethanol, filtrate decompression (65～75 DEG C) is concentrated, is concentrated into relative density 1.1～1.2 (50 DEG C), and spraying is dry, pulverize, obtain the extract (extract powder) of each medical material.
The quality control index of each extract
Physics and chemistry content's index: thin layer is differentiated (TLC), content's index;
Physical index: character, abnormal smells from the patient, moisture (< 5%), ash (< 5%), granularity (100% by 80 orders), heavy metal (< 10ppm) pesticide residues (must not detect);
Microbiological indicator: total number of bacteria (< 1000/g), mycete (< 100/g), Salmonella (must not detect), coliform (must not detect).
(2) preparation method of Rhizoma Polygonati extract
Medical material decocts with water 3 times, 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount is followed successively by 8 times, 7 times, 5 times collecting decoctions, filter, filtrate recycling ethanol, decompression (65～75 DEG C) is concentrated, is concentrated into relative density 1.1～1.2 (50 DEG C), spraying is dry, obtains Rhizoma Polygonati extract (extract powder).
The quality control index of Rhizoma Polygonati extract is the same.
(3) preparation method of curcumin
Medical material adds 75% alcohol reflux 3 times, 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount is followed successively by 7 times, 6 times, 4 times, and merge extractive liquid, filters, reclaim ethanol, filtrate decompression (65～75 DEG C) is concentrated, and refining crystallization is dry, pulverize, obtain curcumin (extract).
The quality control index of curcumin
Content's index: (HPLC) >=95%;
Physical index: character, abnormal smells from the patient, moisture (< 5%), ash (< 1.5%), granularity (100% by 80 orders), heavy metal (< 10ppm), As (< 2ppm), residual solvent (European Pharmacopoeia), pesticide residues (must not detect)
Microbiological indicator: total number of bacteria (< 1000/g), mycete (< 100/g), Salmonella (must not detect), coliform (must not detect).
2. preparations shaping process
Take in proportion each extract, stir, mix, granulate, in incapsulating, to obtain final product.
The present invention adopts extract and the extract of Chinese herbal medicine, through Chinese medicine preparation technical matters, claims in proportion to join, admixes and mix, granulate, and incapsulates and forms compound Chinese medicinal preparation.
Feature of the present invention
One, to treat cancer be to start with from entirety in the present invention, by improving autoimmune ability, activates self antioncogene, improves endocrine environment, strengthens human body metabolism ability, strengthening the body resistance, thus reach the object of thorough healing cancer.Utilize the present invention to treat cancer, avoid operation and chemicotherapy, make extensive patients avoid the misery of operation and chemicotherapy.Being different from other curing cancer drug is that said preparation is without any side effect, it is unlike other medicines treating the poisonous disease with poisonous drugs, directly removes killing cancer cell with medicine, but uses without any the medicine deexcitation of toxicity, transfers human body self antioncogene, there is the diffusion of targeting anticancer, make people's state of getting well.To human five internal organs's six internal organs and cell without any destruction.
Two, the present invention has obvious therapeutic effect to polytype cancer, and analgesic effect is fairly obvious, has alleviated patient suffering, and extending life improves life quality.More remarkable treatment effect, medical material is high through purification effective ingredient, absorbs through target position treatment cancer through oral administration, transfers human body self antioncogene, effectively alleviates and cures disease.
Three, the extraction of the each prescription composition of the present invention is refining, adopt modern Chinese medicine to extract new technique, each taste Chinese medicine is got indescribably, remove impurity, is refined into standard extract, mix and form by proportioning blending, this Chinese medicine preparation effective ingredient or position are clear and definite, have strict quality standard, and the concordance of analytical method makes system easy to control the quality, there is pharmacodynamic substances basis and specific pharmacologically active, stable curative effect.
The present invention extracts effective ingredient in Chinese crude drug, and active substance carries out compatibility, through its representative composition determined curative effect of Chinese crude drug extracting, low toxicity, safety.Wherein the quality standard of Chinese medicine extraction medicine is formulated and is had important effect, and the Effective Component of Chinese Medicine of extraction is compared with crude drug, and its curative effect is better than crude drug.Therefore we do not select crude drug (decoction pieces) in prescription compatibility, but select its extract to carry out compatibility, and through clinical use, therapeutic effect is fairly obvious, for Chinese traditional treatment cancer is created Yi Tiaoxin road.
Prescription foundation
Cancer is common in the world a kind of disease, is called the category of tumor in China's traditional Chinese medical science, has now become the second largest killer of harm humans life in the world.At present in the world cancer is not also had to special treatment way, be called as incurable disease, incurable disease.Tumor of a great variety, but its characteristic has general character, no matter be to cause canceration by extrinsic factor or intrinsic factor, all owing to existing with cancer related gene sudden change has occurred on the chromosome of cell, be that proto-oncogene and antioncogene morph under the impact of extraneous cancerigenic factor, cause normal Growth of Cells and division, out of control and become cancerous cell.Because variation has occurred gene, cell body control imbalance, the uncontrolled malignant proliferation of cancerous cell.Treat cancer and will manage to set about from proto-oncogene and antioncogene, in transfer body, the disease-resistant gene of oneself, could fundamentally eliminate cancerous cell malignant proliferation, makes proto-oncogene and antioncogene balanced growth out of control in body, makes human body in healthy state.The method for the treatment of in the world cancer is now a lot, but fundamentally fails to deal with problems, and causes people to talk canceration color.In order to solve this difficult problem, we are through research for many years, think that causing the principal element of the pernicious increase of human cancer cell is the interference that people's consciousness is subject to negative consciousness, makes gene generation canceration.How impelling antioncogene propagation, is the basic for the treatment of cancer.Through research for many years, with extract compositing formula in Rhizoma Curcumae Longae, Fructus Forsythiae, Radix Sophorae Tonkinensis, Radix Bupleuri etc., make capsule.This medicine, through animal experiment and clinical trial, has activation, transfer effect to anticancer, without any toxicity, to human normal cell without any injury.
For cancer must, to transfer human body antioncogene as this, be theory of Chinese medical science of the present invention basis, through research for many years and experiment repeatedly, finally, taking curcumin as monarch, researches and develops successfully.
1. selecting curcumin is monarch drug, and the user of overdose is to being correct
Rhizoma Curcumae Longae is recorded in Tang Materia Medica the earliest as Chinese medicine, has more than 1300 year history apart from the present.Curcumin is the fat-soluble phenols pigment of one extracting from the rhizome of Rhizoma Curcumae Longae, is a kind of natural food additive.Main effect that Rhizoma Curcumae Longae plays a role is: have removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia, through we for many years clinical observation curcumin can transfer human body antioncogene, carry out the apoptosis of inducing tumor cell by increasing the permeability of mitochondrial membrane, do not injure again Normocellular existence, growth and transfer that can inhibition tumor cell, can block in vivo the signal conduction pathway of tumor cell, thereby reach the object of thorough healing cancer.We treat hepatocarcinoma, pulmonary carcinoma, rectal cancer, gastric cancer, breast carcinoma, have obtained beyond thought effect, and some liver cancer patients are fully recovered and gone on work unit.Now the antitumaous effect of Chinese medicine is more and more approved by international community, to the effect for cancer of curcumin in the world many scientific research departments study, we use early the research of curcumin, have obtained reliable effect on clinical treatment.
2. the selection of ministerial drug is correct, impels the performance of monarch drug usefulness the best.
In side taking Rhizoma Polygonati extract, Radix Sophorae Tonkinensis extract as minister, to strengthen the enhancing of antioncogene effect of monarch drug curcumin.Rhizoma Polygonati enters spleen, lung, stomach three warps, spleen reinforcing, and lung moistening, promotes the production of body fluid, and its effect is, invigorating the spleen and replenishing QI, except rheumatism, settling five organs: mend five kinds of strain and seven kinds of impairment, help muscles and bones, strengthening the spleen stomach, mends all void, replenishing essence marrow, controls spirit not enough, hepatasthenia dim eyesight.Modern medicine study proves that Rhizoma Polygonati has the effect of resisting pathogenic microbes, has resisting fatigue, antioxidation, and antiviral effect, can delaying senility function.Radix Sophorae Tonkinensis nature and flavor bitter cold, returns through in cardiopulmonary, large intestine three warps, can heat-clearing and toxic substances removing, and two medicines be monarch, can removing blood stasis circulation of qi promoting, control in abdomen the long-pending hemorrhoid of knot disobedient, remove wind heat, subduing inflammation.Rhizoma Polygonati, Radix Sophorae Tonkinensis and monarch drug curcumin compatibility, more can impel the best performance of monarch drug performance.
3. adjuvant amount is little, but its conditioning to the vital organs of the human body helps the monarch and his subjects' two medicine performance effects not to be sneezed at.
In side, make taking Fructus Forsythiae, Radix Bupleuri, the Rhizoma Pinelliae, Rhizoma Chuanxiong as assistant, Fructus Forsythiae hardship is slightly cold, and it is through returning lung, the heart, gallbladder, can heat-clearing and toxic substances removing, and eliminating carbuncle eliminating stagnation.Radix Bupleuri can enter liver and gall two warps, can yang invigorating bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, can the meridian dredging, QI and blood regulating, dispersing swelling and dissipating binds, the research of heat-clearing and toxic substances removing modern medicine and pharmacology think that Radix Bupleuri can improve immune function of human body, phagocytic function enhancing, Natural killer activity are strengthened, improve special viral antibody titre, improve lymphocyte and turn core rate.Rhizoma Chuanxiong, the Rhizoma Pinelliae can blood circulation promoting and blood stasis dispelling, stomach function regulating is except dry.All medicines tie in above, gather altogether correction gas, promoting blood circulation to remove obstruction in the collateral, dispersing swelling and dissipating binds, effect that can human activin cancer inhibitor cell.
The pharmacological toxicology research conclusion of compound Chinese medicinal preparation of the present invention
Through new drug evaluation research center, Xi'an animal experiment, to SMMC-7721, the nude mice carcinoma transplanted of HPG2 has stronger inhibitory action, disappearing at the accurate word 22-2022495 of same traditional Chinese medicines lot number, cancer is flat opposes and should test, it is flat that compound Chinese medicinal preparation of the present invention is greater than to the inhibitory action of tumor the cancer that disappears, and through animal acute toxicity test, under 5 gs/kg of conditions of limit metering, do not see rope to obvious toxic reaction, this dosage is equivalent to 7 times of people's usual amounts.
Below be respectively that infective use is summed up
One, adopt Chinese medicine preparation Hepatoma therapy 40 examples of the present invention, obtained comparatively satisfied curative effect.Now be reported as follows.
Hepatocarcinoma is one of common malignant tumor, state of an illness weight, poor prognosis, when most of Finding case, belong to middle and advanced stage, lose surgical engine meeting, wherein part patient loses compensatory or portal vein tumor thrombus, merging Organ Failure, fills the air the reasons such as liver because of liver function, is not suitable for TACE treatment.Cannot accept the liver cancer patient of western medical treatment for late period, existing report is as follows:
1 clinical data
1.1 physical data are collected in JIUYUE, 2010～2012 and are entered voluntarily the patients with hepatocellular carcinoma in late period that group observation is treated year January, wherein male's 29 examples, and women's 11 examples, all turn out to be late primary liver cancer through iconography or cytology.Tumor is single-shot massive type 7 examples, diffuse type 19 examples, multiple nodules type 14 examples; Grade of liver function: Child-A6 example, Child-B23 example, Child-C11 example; The median age 70 years old (63～80 years old).Be divided at random two groups, relatively there was no significant difference (P>0.05) of two groups of physical data, has comparability.
The all observation patient clinicals of 1.2 Therapeutic Method assessment survival period is more than 3 months, and KPS40 divides, can not operation, TACE or be reluctant to accept western medical treatment, and having can measurement index, and compliance is good, cardiopulmonary normal renal function.3 tablets/time of matched group oral administered compound Mylabris capsules, 2 times/d; 3 tablets/time, the oral preparation of the present invention of observation group, 2 times/d.Before entering group, improve routine examination, 1 month recurrence of disease at the same time next year of taking medicine have a blood test routine, Liver and kidney merit, abdominal CT Estimating curative effect.Responder continues to take, and checks related content, Estimating curative effect in the time of 3 months.The person that continues drug administration afterwards, observes life cycle.
The tumor short term effect standard [1] that 1.3 curative effects and untoward reaction evaluation criterion are formulated according to UICC and Ministry of Public Health is divided into alleviates (CR), partial rcsponse (PR), stable (SD) and progress (PD) completely.CR+PR+SD is effectively, according to KPS scoring and the improvement of table assessment quality of life quality of life.Untoward reaction is evaluated with reference to the relevant toxicity of anticancer agents grade scale of WHO.Adopt outpatient service and Effect of follow-up visit by telephone, until the dead end of patient.
1.4 statistical analysis life cycles, life quality was drawn survival curve as less important index Kaplan-Meier method as unique terminal index (from diagnosing into group to the death time), logrank inspection.All data statisticss adopt SPSS13.0 software analysis.
2 results
The recent effective percentage 85% of 2.1 Short-term group, 70%, two group of comparative observation group of matched group is better than matched group.In table 1.
Table 1 liang group short term effect comparative example
2.2 compare two groups of no significant differences (P>0.05) aspect KPS scoring, QOL.
Statistics demonstration 2.3 life cycles observation group is being better than matched group (P<0.05) aspect improving life cycle.In table 2.
Table 2 liang group comparative example life cycle
3 discuss
Hepatocarcinoma be a multistage, multifactor cumulative function, through starting, the step such as short cancer and evolution, and multiple gene occurs and the result of conflict.When most of liver cancer patient diagnosis, enter middle and advanced stage, and liver blood is in plentiful supply, easily inside and outside organ, haematogenous shifts, and just occurs send out and occur new cancer in infringement in blood vessel, portal vein tumor thrombus formation, liver when therefore liver is everlasting, tumor body is little, causes treatment difficulty.Molecular targeted therapy had been obtained significant result in recent years, but still had many problems, and in conjunction with China's economy, many patients cannot bear.The report of Chinese medicine hepatocarcinoma, treats or Chinese medicine preparation interventional therapy and therapy of combining Chinese and Western medicine aspect have all obtained some achievements from determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, differential diagnosis of diseases.Chinese medicine not only plays the effect of doctor trained in Western medicine auxiliary treatment in the therapeutic process of hepatocarcinoma, and taking Chinese medicine as main general treatment measures more remarkable.The patient that especially cannot accept western medical treatment for late period, mostly the past is to abandon or give placebo, and the intervention for the treatment of by Chinese herbs in recent years extends life cycle to some extent, quality of life is improved.
This project selection patient is all primary hepatic carcinoma patients in advanced stage patients, cannot take the patient of western medical treatment or refusal western medical treatment.Select FUFANG BANMAO JIAONANG oral for one group, select compound Chinese medicinal preparation of the present invention oral for one group.FUFANG BANMAO JIAONANG contains Mylabris, Radix Ginseng, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Fel Ursi powder, Radix Glycyrrhizae etc., use unique high-tech biotechnology to extract the main component in prescription: norcantharidin, Radix Et Caulis Acanthopanacis Senticosi polysaccharide, astragaloside, astragalus polysaccharides, ursodesoxycholic acid, Oleum Curcumae, glycyrrhizin etc., have the function of removing blood stasis repercussive, counteracting toxic substances phagedenoma.Can inducing apoptosis of tumour cell, suppress tumor neogenetic blood vessels, there is Reversal of multidrug resistance, and there is significant immunoregulation effect, bone marrow is had to protective effect, research shows really can extend the life cycle of primary hepatocarcinoma.Observation group selects compound Chinese medicinal preparation of the present invention, prescription is mainly Radix Bupleuri, Fructus Forsythiae, Radix Sophorae Tonkinensis, Rhizoma Curcumae Longae, the Rhizoma Pinelliae, Rhizoma Chuanxiong etc., and through modern pharmacology research, wherein contained Fructus Forsythiae alkaloid, matrine, pterocarpin, 1-Russian red clover Koryo Chinese scholartree glycoside, saikoside, curcumin, trigonelline etc. all have antitumaous effect.Result of study demonstration, observation group is being better than matched group aspect improving life cycle.
For primary liver cancer in senile patients patient (age >65 year), there is more underlying diseases more, body function falls into a decline gradually simultaneously, reactivity to external world and post-traumatic repair ability decline, immune function goes down, especially anti-cancer ability is low, treatment difficulty.Take definite curative effect, without any side effects, obviously extending life and the treatment of alleviating disease are to expect at present.Result of study demonstration, compound Chinese medicinal preparation of the present invention has certain curative effect in the prolongation PHC in old age survival of patients phase with aspect improving the quality of living, and is better than matched group, and clinic is promoted.
Two, Drug therapy intestinal cancer 13 clinical observations of the present invention
Intestinal cancer refers to the malignant change prognosis mala that colorectal mucosa epithelium occurs under the multiple carcinogenic factor effects such as environment or heredity, and mortality rate is higher.Colorectal cancer is the malignant tumor of colorectal mucosa epithelium genesis, is one of modal malignant tumor of digestive tract, the more common intestinal cancer of male, chemicotherapy is the primary treatment means of late tumor, we apply Drug therapy intestinal cancer in late period of the present invention 13 examples, obtain good effect, and existing report is as follows.
1 materials and methods
1.1 physical data
13 routine patients all have pathology and (or) cytodiagnosis, and all cases are adenocarcinoma.Man's 9 examples, female's 4 examples, 26～67 years old age, the median age 57 years old.All patients all have measurable tumor focus, energy objective evaluation curative effect, and clinical stages, is the VI phase.Analysis on hemogram, hepatic and renal function, normal ECG.Take own control test, choose and be diagnosed as pulmonary carcinoma, be reluctant to carry out chemicotherapy or patient that cannot operative treatment (being abandoning cure) and adopt medicine of the present invention to treat.
1.2 Therapeutic Method
Oral medicine of the present invention, every day 3 times, each 5, or follow the doctor's advice.1 month recurrence of disease at the same time next year of taking medicine have a blood test routine, Liver and kidney merit, abdominal CT Estimating curative effect.Responder continues to take, and checks related content, Estimating curative effect in the time of 3 months.The person that continues drug administration afterwards, observes life cycle.
1.3 criterion of therapeutical effect
With reference to WHO curative effect determinate standard, alleviate completely (CR): tumor focus absorbs completely; Partial rcsponse (PR): tumor focus constantly dwindles, but reduced volume is greater than 50%; Stable (SD): tumor focus constantly dwindles, but reduced volume is less than 50%; Progress (PD): tumor focus presents continuous expansion trend, and volume has expanded more than 25%.The objective effective percentage of patient treatment=(alleviation+partial rcsponse completely)/can evaluate case load × 100%, patient disease control rate=(alleviation+partial rcsponse completely+slightly alleviate)/can evaluate case load × 100%.
3 months (people), 6 months (people) of index life cycle, 1 year (people), 2 years (people), 3 years (people).
2 results
2.1 clinical efficacy
Treat in 13 routine patients, reduction of patient is 1 example completely, and partial rcsponse patient is 8 examples, and slight reduction of patient is 1 example, and invalid patient is 3 examples.Objective effective percentage is 69.2%, and disease control rate is 76.9%.
3 months 13 people of index life cycle, 6 months 13 people, 1 year 11 people, 2 years 10 people, 3 years 8 people.
Above-mentioned data show, the objective effective percentage of Drug therapy of the present invention and disease control rate are all higher, illustrate that Drug therapy pulmonary carcinoma effect of the present invention is remarkable.
2.2 untoward reaction
In therapeutic process, all there is not untoward reaction in 13 routine patients with bowel cancers, smoothly by treatment.
3 discuss
Above-mentioned clinical report explanation medicine of the present invention has good curative effect to intestinal cancer, and has no side effect.The selection of rectal cancer treatment of late stage method is very crucial, and rectal cancer Chinese traditional treatment in late period method more and more people receive much attention.Advanced rectal cancer has diffusion more and shifts, and tumor body is not single yet, so operative treatment is unaccommodated, adopts expectant treatment can obtain good effect.For rectal cancer treatment of late stage, the treatment by Chinese herbs Combined with Radiotherapy chemotherapy that adopt are controlled symptom in late period more clinically, stablize the state of an illness.Medicine of the present invention, for the symptom and the misery that alleviate patients with bowel cancer, improves life quality, and extending life increases appetite, reduces the mortality rate of cancer, has its important meaning.
Three, adopt 21 routine patients with lung cancer of Drug therapy of the present invention, and obtain certain therapeutic effect.
Pulmonary carcinoma, as a kind of malignant tumor occurred frequently, has the advantages that clinical cure rate is low, and 5 years survival rates of patient are 5%～10% left and right.The M & M of whole world pulmonary carcinoma constantly rises, and lung cancer mortality has occupied first of malignant tumor, the serious threat mankind's life and health.At present, the Therapeutic Method of pulmonary carcinoma is mainly chemotherapy, but chemotherapy is serious to patient body injury, and its side effect is very strong.Meanwhile, most of patients with lung cancer find time be in, late period, Chemoresistance degree is poor.Therefore, treatment by Chinese herbs pulmonary carcinoma is widely used.
1 data and method
1.1 physical data
Control patients with lung cancer 21 examples, wherein male patient is 11 examples, and female patient is 10 examples, patient age 35～78 years old, and the mean age is 63.5 years old, and the course of disease is 1～3 year.Take own control test, choose and be diagnosed as pulmonary carcinoma, be reluctant to carry out chemicotherapy or patient that cannot operative treatment (being abandoning cure) and adopt medicine of the present invention to treat.
1.2 Therapeutic Method
Oral medicine of the present invention, every day 3 times, each 5, or follow the doctor's advice.1 month recurrence of disease at the same time next year of taking medicine have a blood test routine, Liver and kidney merit, abdominal CT Estimating curative effect.Responder continues to take, and checks related content, Estimating curative effect in the time of 3 months.The person that continues drug administration afterwards, observes life cycle.
1.3 criterion of therapeutical effect
With reference to WHO curative effect determinate standard, alleviate completely (CR): tumor focus absorbs completely; Partial rcsponse (PR): tumor focus constantly dwindles, but reduced volume is greater than 50%; Stable (SD): tumor focus constantly dwindles, but reduced volume is less than 50%; Progress (PD): tumor focus presents continuous expansion trend, and volume has expanded more than 25%.The objective effective percentage of patient treatment=(alleviation+partial rcsponse completely)/can evaluate case load × 100%, patient disease control rate=(alleviation+partial rcsponse completely+slightly alleviate)/can evaluate case load × 100%.
3 months (people), 6 months (people) of index life cycle, 1 year (people), 2 years (people), 3 years (people).
2 results
2.1 clinical efficacy
Treat in 21 routine patients, reduction of patient is 1 example completely, and partial rcsponse patient is 10 examples, and slight reduction of patient is 3 examples, and invalid patient is 7 examples.Objective effective percentage is 52.4%, and disease control rate is 66.7%.
3 months 21 people of index life cycle, 6 months 17 people, 1 year 20 people, 2 years 10 people, 3 years 8 people.
Above-mentioned data show, the objective effective percentage of Drug therapy of the present invention and disease control rate are all higher, illustrate that Drug therapy pulmonary carcinoma effect of the present invention is remarkable.
2.2 untoward reaction
In therapeutic process, all there is not untoward reaction in 21 routine patients, smoothly by treatment.
3 discuss
At present, the Main Means for the treatment of pulmonary carcinoma is exactly chemotherapy, but this method is to allowing patient's body and mind bear huge misery.The traditional Chinese medical science thinks that human righteousness is deficient, the invasion of heresy poison, makes QI and blood stasis, blockage of main and collateral channels, poison gather tumor of a specified duration and that form.Medicine of the present invention can tonifying both YIN and YANG, and strengthening the body resistance improves patient body immunity, and the tumor in patient body is effectively suppressed, and extends survival of patients period.In 21 routine patients of report, before treatment, the symptoms such as patient's spiritlessness and weakness, cough, spitting of blood improve, and illustrate that tcm therapy can improve patient's quality of life herein.In therapeutic process, all there is not untoward reaction in 21 routine patients, smoothly by treatment.Therefore, medicine of the present invention has good curative effect aspect lung cancer therapy, and can extend patient's life period, improves patient's quality of life, is worthy to be popularized.
Four, the routine clinical observation on the therapeutic effect of Drug therapy renal carcinoma 15 of the present invention
Renal carcinoma is one of modal malignant tumor of urinary system, occupies the second of urinary system malignant tumor, existing diffusion and transfer in various degree when approximately 20%～30% renal cell carcinoma patients is gone to a doctor.Metastatic renal cell cancer is all insensitive to traditional Radiotherapy chemotherapy, and prognosis is poor, and median survival interval is about 12 months, 5 years survival rate less thaies 10%.Therefore, need to make great efforts to inquire into the method for new treatment metastatic renal cell carcinoma, to improve patient's clinical efficacy.Renal cell carcinoma is relevant with autoimmune function disorder.We adopt patients with renal cell carcinoma 15 examples of Drug therapy of the present invention, obtain good effect, and existing report is as follows.
1. materials and methods
1.1 clinical data
The patients with renal cell carcinoma that 15 examples are made a definite diagnosis through pathology, wherein male's 10 examples, women's 5 examples, 20～77 years old age, the median age 57 years old, and without infection such as serious virus, antibacterials, without serious hepatic and renal function injure, without severe cardiac cerebrovascular disease, take own control test, choose and be diagnosed as renal carcinoma, be reluctant to carry out chemicotherapy or patient that cannot operative treatment (being abandoning cure) and adopt medicine of the present invention to treat.
1.2 Therapeutic Method
Oral medicine of the present invention, every day 3 times, each 5, or follow the doctor's advice.1 month recurrence of disease at the same time next year of taking medicine have a blood test routine, Liver and kidney merit, abdominal CT Estimating curative effect.Responder continues to take, and checks related content, Estimating curative effect in the time of 3 months.The person that continues drug administration afterwards, observes life cycle.
1.3 criterion of therapeutical effect
With reference to WHO curative effect determinate standard, alleviate completely (CR): tumor focus absorbs completely; Partial rcsponse (PR): tumor focus constantly dwindles, but reduced volume is greater than 50%; Stable (SD): tumor focus constantly dwindles, but reduced volume is less than 50%; Progress (PD): tumor focus presents continuous expansion trend, and volume has expanded more than 25%.The objective effective percentage of patient treatment=(alleviation+partial rcsponse completely)/can evaluate case load × 100%, patient disease control rate=(alleviation+partial rcsponse completely+slightly alleviate)/can evaluate case load × 100%.
Life cycle index 3 months, 6 months, 1 year, 2 years, 3 years.
2. result
2.1 clinical efficacy
Treat in 15 routine patients with renal cell carcinoma, reduction of patient is 1 example completely, and partial rcsponse patient is 8 examples, and patients with mild is 2 examples, and invalid patient is 4 examples.Objective effective percentage is 60.0%, and disease control rate is 73.3%.
3 months 14 people of index life cycle, 6 months 14 people, 1 year 9 people, 2 years 6 people, 3 years 4 people.
Above-mentioned data show, the objective effective percentage of Drug therapy of the present invention and disease control rate are all higher, illustrate that Drug therapy renal carcinoma effect of the present invention is remarkable.
2.2 untoward reaction
In therapeutic process, all there is not untoward reaction in 15 renal carcinoma example patients, smoothly by treatment.
3. discuss
Above-mentioned report explanation medicine of the present invention has good curative effect to renal carcinoma, and has no side effect.Medicine of the present invention, for the symptom and the misery that alleviate patients with renal cell carcinoma, improves life quality, and extending life increases appetite, reduces the mortality rate of cancer, has its important meaning.
Five, Drug therapy 24 Cases of Gastric Carcinoma of the present invention clinical observation
Gastric cancer is the modal tumor of digestive system, and chemicotherapy is the primary treatment means of late tumor.Gastric cancer mortality occupies the total 5 years survival rates 10%～21% in all kinds of tumors prostatitis, within 60 years old, above elder patients with gastric cancer accounts for 40% of all patients with gastric cancer, most research report shows that 5 years survival rates of gerontal patient are a little less than non-senile, but still occupies the anteposition of Tumor-assaciated death.Chinese medicine is having unique effect aspect the treatment of cancer, we apply Drug therapy late gastric cancer 24 examples of the present invention and obtain good effect, and existing report is as follows.
1 materials and methods
1.1 physical data
24 Cases of Gastric Carcinoma patient all has pathology and (or) cytodiagnosis.Man's 11 examples, female's 13 examples, 29～69 years old age, the median age 59 years old.All patients all have measurable tumor focus, can objective evaluation curative effect.Clinical stages, is the VI phase.Analysis on hemogram, hepatic and renal function, normal ECG.Take own control test, choose and be diagnosed as gastric cancer, be reluctant to carry out chemicotherapy or patient that cannot operative treatment (being abandoning cure) and adopt medicine of the present invention to treat.
1.2 Therapeutic Method
Oral medicine of the present invention, every day 3 times, each 5, or follow the doctor's advice.1 month recurrence of disease at the same time next year of taking medicine have a blood test routine, Liver and kidney merit, abdominal CT Estimating curative effect.Responder continues to take, and checks related content, Estimating curative effect in the time of 3 months.The person that continues drug administration afterwards, observes life cycle.
1.3 the standard of curative effect evaluation
With reference to WHO curative effect determinate standard, alleviate completely (CR): tumor focus absorbs completely; Partial rcsponse (PR): tumor focus constantly dwindles, but reduced volume is greater than 50%; Stable (SD): tumor focus constantly dwindles, but reduced volume is less than 50%; Progress (PD): tumor focus presents continuous expansion trend, and volume has expanded more than 25%.The objective effective percentage of patient treatment=(alleviation+partial rcsponse completely)/can evaluate case load × 100%, patient disease control rate=(alleviation+partial rcsponse completely+slightly alleviate)/can evaluate case load × 100%.
3 months (people), 6 months (people) of index life cycle, 1 year (people), 2 years (people), 3 years (people).
2 results
2.1 clinical efficacy
In the routine patients with gastric cancer of Drug therapy 24 of the present invention, reduction of patient is 2 examples completely, and partial rcsponse patient is 12 examples, and slight reduction of patient is 4 examples, and invalid patient is 6 examples.Objective effective percentage is 58.3%, and disease control rate is 75.0%.
3 months 23 people of index life cycle, 6 months 19 people, 1 year 15 people, 2 years 11 people, 3 years 7 people.
2.2 toxicity
In therapeutic process, all there is not untoward reaction in 24 routine patients, smoothly by treatment.
3 discuss
Above-mentioned report explanation medicine of the present invention has good curative effect to gastric cancer, and has no side effect.Screening Method of Gastric Cancer accomplishes that general early diagnosis still has many difficulties, when many patients make a definite diagnosis, has been late period, can not adopt radical operation at all.Like this, Chinese medicine just becomes the important measures that improve therapeutic effect.After oneself loses surgical engine meeting or only does Palliative short circuit operation to some late gastric canceres (3 phases and 4 phases), more need Chinese medicine, to improve curative effect, to extend life cycle.Medicine of the present invention, for the symptom and the misery that alleviate patients with gastric cancer, improves life quality, and extending life increases appetite, reduces the mortality rate of cancer, has its important meaning.
Only choose model case introduced below.
Case 1: Wang, man, 74 years old, renal carcinoma, find renal carcinoma and reach an advanced stage in August, 2011, and doctor informs and can only live 1 year, and patient's emotion, health are all very poor, also abandoning cure.Start to take compound Chinese medicinal preparation of the present invention in October, 2012, takes medicine once all rear effects clearly, and pain disappears, just basic disappearance of symptom after adhering to taking medicine 10 months, Everything is fine, is in can pick grandson and go to school, have a meal also normal, existence is in March, 2014, because of other disease death.According to circumstances analyze.If early find, early medication, expection may be better.
Case 2: rope, female, 74 years old, hepatobiliary cancer, find hepatobiliary cancer in Affiliated Hospital of Shaanxi College of Traditional Chinese Medicine in November, 2010, oral compound Chinese medicinal preparation of the present invention in 2012, take medicine the large change of symptom after half a year, I feel healing of oneself, remove examination in hospital, and it is impossible that doctor feels, done repeatedly check, all are all normally later.
Case 3: Wang, man, 43 years old, hepatocarcinoma, finds hepatocarcinoma in Shaanxi people provincial hospital in 2012, live every year twice or thrice hospitalization, having an injection, it is all not all right to take medicine, and doctor says to only have operative treatment, and only has 2 years survival periods after operation, just go home to wait if do not performed the operation, yet operation out of funds of family afraid at heart at that time, does not have much hope yet, and patient just firmly leaves hospital and goes home to wait.Take compound Chinese medicinal preparation of the present invention by introduction, do not take during this time other medicine, take compound Chinese medicinal preparation of the present invention always.All symptoms after half a year of taking medicine have not all had, and just start working, and compound Chinese medicinal preparation of the present invention has been taken two-and-a-half years, goes to again Shaanxi people provincial hospital to check, all are normal.Just withdraw compound Chinese medicinal preparation of the present invention, done again check in March, 2014, and all are normal, and doctor says that this is impossible thing.
Case 4: in certain, female, 59 years old, pulmonary carcinoma, check out pulmonary carcinoma in The Fourth Military Medical University in January, 2014, the multiple metastatic tumor of lymph metastasis tumor liver, hospitalization, after leaving hospital, takes after compound Chinese medicinal preparation of the present invention March, I have a rosy complexion at spirit, go to again hospital to check, substantially have no clear and definite abnormal, doctor all feel very magical some do not believe.
Case 5: Zhang, female, 70 years old, gastric cancer, after diagnosis of gastric cancer in 2012, the difficulty of always having a meal, stomach is felt bad, and pain is weak, and spirit is poor, and face jaundice, sleeps poor, recent aggravation.Take improving situation after compound Chinese medicinal preparation of the present invention January, medication, after 3 months, recovers fine, pays a return visit 2 times, and situation is good time by time.
Case 6: Lee, female, 60 years old, intestinal cancer, finds intestinal cancer in February, 2013, in bad order after hospitalization chemotherapy, introduce through friend, take compound Chinese medicinal preparation of the present invention, medication is not ached after February, stool depletion of blood has not also ached, and disease disappears substantially, adheres to park dancing every day.
Effect of the present invention
The present invention is using Chinese medicine extract as raw material, carry out compatibility, treatment cancer has following benefit, the one, Chinese traditional treatment cancer is to start with from entirety, by improving autoimmune ability, activate immunity ability, improve endocrine environment, strengthen human body metabolism ability, strengthening the body resistance, thus reach the object of thorough healing cancer.The 2nd, the present invention is the preparation made from the effective ingredient of Chinese medicine extraction or effective site, and effective ingredient or position are clear and definite, quality controllable, and effect is clear and definite, is the one trend of Chinese medicine preparation development.The 3rd, the present invention compares without any side effects with other cancer drugs, the treating the poisonous disease with poisonous drugs that is different from other cancer therapy drugs directly kills cancerous cell, but transfer human body self antioncogene, can cancer cell specific induction of apoptosis, growth that can anticancer with shift the transmission channels of blocking cancer cell signals in human body.The 4th, analgesic effect of the present invention is fairly obvious, and 90% patient takes rear pain relief or disappearance.The 5th, the present invention is with low cost, can alleviate patient's financial burden.The 6th, the present invention makes preparation and need not boil medicine, and portably uses conveniently.
Specific embodiment
Embodiment 1 presses column weight amount weighting raw materials (unit: g)
110 parts of curcumins, 25 parts of Radix Sophorae Tonkinensis extracts, 35 parts of Rhizoma Polygonati extracts, 15 parts of Fructus Forsythiae extracts, 25 parts of Radix Bupleuri extracts; 25 parts of Rhizoma Chuanxiong extracts, 15 parts of Rhizoma Pinelliae extracts;
Embodiment 2 presses column weight amount weighting raw materials (unit: g)
125 parts of curcumins, 15 parts of Radix Sophorae Tonkinensis extracts, 45 parts of Rhizoma Polygonati extracts, 25 parts of Fructus Forsythiae extracts, 18 parts of Radix Bupleuri extracts; 18 parts of Rhizoma Chuanxiong extracts, 25 parts of Rhizoma Pinelliae extracts;
Embodiment 3 presses column weight amount weighting raw materials (unit: g)
118 parts of curcumins, 18 parts of Radix Sophorae Tonkinensis extracts, 38 parts of Rhizoma Polygonati extracts, 22 parts of Fructus Forsythiae extracts, 15 parts of Radix Bupleuri extracts; 15 parts of Rhizoma Chuanxiong extracts, 18 parts of Rhizoma Pinelliae extracts;
The preparation method of above-described embodiment is: in writing out a prescription, each taste Chinese crude drug, according to the clean system of regulation under Chinese Pharmacopoeia and this kind item of drug standard, is carried extract according to preparation technology's essence of each component, stirs, and mixes, and granulates, and incapsulates, and to obtain final product.
Function cures mainly: tonifying both YIN and YANG, strengthening the body resistance.Be mainly used in the treatment of hepatocarcinoma, pulmonary carcinoma, gastric cancer, rectal cancer.
Using method: oral, every day 3 times, each 5, or follow the doctor's advice.
Specification: 0.4g/ grain.
Storage: sealing.
The present invention is through clinical practice, and general patient's medication takes effect for 3～7 days, and slow 10～15 days take effect, and symptom is improved, pain relief, and medicine of the present invention 15 days is a course for the treatment of, medication can have positive effect or rehabilitation 2～3 courses for the treatment of, is difficult for recurrence after rehabilitation.This product is better to the patient's effect without carcinosis radiotherapy and chemotherapy.
Claims (6)
1. treat a compound Chinese medicinal preparation for cancer, made by weight by following bulk drugs:
Curcumin 110-130 part, Radix Sophorae Tonkinensis extract 10-30 part, Rhizoma Polygonati extract 30-50 part, Fructus Forsythiae extract 10-30 part, Radix Bupleuri extract 10-30 part, Rhizoma Chuanxiong extract 10-30 part, Rhizoma Pinelliae extract 10-30 part;
The preparation method of above-mentioned compound Chinese medicinal preparation is:
(1) preparation method of Radix Sophorae Tonkinensis, Rhizoma Chuanxiong, the Rhizoma Pinelliae, Fructus Forsythiae, Radix Bupleuri extract
Each medical material adds respectively 35% alcohol reflux 3 times, 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount is followed successively by 7 times, 6 times, 4 times, and merge extractive liquid, filters, reclaim ethanol, 65～75 DEG C of filtrate decompression are concentrated, and while being concentrated into 50 DEG C of relative densities 1.1～1.2, spraying is dry, pulverize, obtain the extract of each medical material;
(2) preparation method of Rhizoma Polygonati extract
Medical material decocts with water 3 times, and 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount was followed successively by 8 times, 7 times, 5 times collecting decoctions, filter filtrate recycling ethanol, 65～75 DEG C of concentrating under reduced pressure, while being concentrated into 50 DEG C of relative densities 1.1～1.2, spraying is dry, obtains Rhizoma Polygonati extract;
(3) preparation method of curcumin
Medical material adds 75% alcohol reflux 3 times, and 3 hours for the first time, 2 hours for the second time, 1.5 hours for the second time, solvent amount was followed successively by 7 times, 6 times, 4 times, merge extractive liquid,, filter, reclaim ethanol, 65～75 DEG C of filtrate decompression are concentrated, refining crystallization, dry, pulverize, obtain curcumin;
(4) take in proportion each extract, stir, mix, granulate, in incapsulating, to obtain final product.
2. a compound Chinese medicinal preparation for the treatment of cancer is in the application for the treatment of in pulmonary carcinoma disease medicament.
3. a compound Chinese medicinal preparation for the treatment of cancer is in the application for the treatment of in gastric cancer disease medicament
4. a compound Chinese medicinal preparation for the treatment of cancer is in the application for the treatment of in intestinal cancer disease medicament.
5. a compound Chinese medicinal preparation for the treatment of cancer is in the application for the treatment of in renal carcinoma disease medicament.
6. a compound Chinese medicinal preparation of the treating cancer application in Hepatoma therapy disease medicament.
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| CN106310045A (en) * | 2016-10-09 | 2017-01-11 | 南宁多灵生物科技有限公司 | Traditional Chinese medicine composition for treating renal carcinoma |
| CN113018355A (en) * | 2021-03-16 | 2021-06-25 | 陈则均 | Auxiliary external application medicine for thoracic cavity tumor and abdominal cavity tumor and using method thereof |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN1390588A (en) * | 2002-08-06 | 2003-01-15 | 王凯 | Composite medicine for treating leukemia |
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| CN106310045A (en) * | 2016-10-09 | 2017-01-11 | 南宁多灵生物科技有限公司 | Traditional Chinese medicine composition for treating renal carcinoma |
| CN113018355A (en) * | 2021-03-16 | 2021-06-25 | 陈则均 | Auxiliary external application medicine for thoracic cavity tumor and abdominal cavity tumor and using method thereof |
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