CN104042847A - Lipid-lowering pills for treating hyperlipidaemia and preparation method thereof - Google Patents
Lipid-lowering pills for treating hyperlipidaemia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses lipid-lowering pills for treating hyperlipidaemia and belongs to the technical field of the medicines. The lipid-lowering pills are prepared from the following raw materials in parts by weight: 10-45 parts of herba taxilli, 15-40 parts of the root of radix puerariae, 10-35 parts of Chinese yam, 10-30 parts of rheum officinale, 12-40 parts of hawthorn, 15-40 parts of salviae miltiorrhizae, 6-25 parts of safflower, 8-35 parts of rhizoma alismatis, 5-35 parts of herba artemisiae scopariae and 10-30 parts of dandelion. A preparation method of the lipid-lowering pills comprises the steps of weighing, the preparation of a cream, the preparation of a powder, and pelleting; the preparation of the cream comprises extracting, concentrating and collecting the cream; and the preparation of the powder comprises grinding, sterilizing, mixing of the powder, drying, grinding and total mixing. The lipid-lowering pills for treating the hyperlipidaemia are confirmed in medicinal material formulation and dosage, and have the advantages of good treatment effect, high cure rate and no toxic and side effects; and the preparation method is simple to operate, convenient in preparation and low in cost.
Description
Technical field
The invention belongs to medical technical field, be specifically related to a kind of fat reducing pill for the treatment of hyperlipemia and preparation method thereof.
Background technology
Hyperlipemia is because blood lipid metabolism gets muddled, and lipid metabolism or transhipment are abnormal, make the paranormal disease of lipid level in blood plasma, are common clinical, frequently-occurring disease, is again the key factor that causes cardiovascular and cerebrovascular disease.Take giddy, dizziness, headache, feeling of oppression and pain in the chest, abdominal distention, obesity etc. is principal character.Along with the raising of China's living standards of the people, the variation of dietary structure and life style, the sickness rate of primary disease is ascendant trend year by year.Hyperlipidemia can be divided into constitutional and Secondary cases two classes.Constitutional is with congenital and hereditary relevant, due to single-gene defect or polygenes defect, make to participate in receptor, enzyme or the apolipoprotein caused by abnormal of lipoprotein transhipment and metabolism, or due to environmental factors (diet, nutrition, medicine) with cause by unknown mechanism.The multiple metabolic disorders (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal gland's sebum hyperfunctioning) of being born in of Secondary cases, or with other factors as, age, sex, season, drink, smoking, diet, physical exertion, emotional activity etc. is relevant.To be lipid deposit caused xanthoma and lipid deposits caused arteriosclerosis at blood vessel endothelium in intradermal to its main clinical manifestation.Although hyperlipidemia can cause xanthoma, its incidence rate is also not bery high; And atherosclerotic generation and development are a kind of slowly progressive processes.Therefore most of patients non-evident sympton and abnormal sign under normal conditions.Many people just find that there is serum ester gp level while carrying out blood biochemical check due to other reasons to raise.Long-term dyslipidemia can cause atherosclerosis, increase the M & M of cardiovascular and cerebrovascular disease.
It is main at present the treatment of hyperlipemia mainly being adopted to Western medicine, and main cause is that Western medicine is rapid-action, and stable curative effect, is subject to everybody favor, but Western medicine has toxic and side effects in various degree, easily produces drug dependence.And Chinese medicine is in treatment hyperlipemia, prevent that from there is unique advantage the aspects such as cardiovascular and cerebrovascular disease generation, its curative effect is sure, lasting, side effect is little, is that Western medicine institute is incomparable.Therefore, the medicament of the efficient treatment of searching hyperlipemia is imperative.
Summary of the invention
The object of the invention is to overcome the shortcoming of prior art, a kind of fat reducing pill for the treatment of hyperlipemia is provided, this fat reducing pill has been determined medical material prescription and drug dose, has advantages of that therapeutic effect is good, cure rate is high, has no side effect;
Another object of the present invention is to provide a kind of preparation method for the treatment of the fat reducing pill of hyperlipemia, the method is simple to operate, easy to prepare, with low cost.
Object of the present invention is achieved through the following technical solutions: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts:
Further, it is comprised of the raw material of following weight parts:
Preferably, it is comprised of the raw material of following weight parts:
A preparation method for the treatment of the fat reducing pill of hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 5～7 times of extraction pot Chinese medicine weight, boiling time is 50～70min, the amount that adds for the second time drinking water is 3～5 times of extraction pot Chinese medicine weight, boiling time is 50～70min, and described decoction for the first time also comprises drug immersion 25～35min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.24～1.27 clear paste, the pressure of described concentrating under reduced pressure is 0.01～0.15MPa, and thickening temperature is 70～90 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of described cold room is 2～5 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 150～180 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 115～130 ℃, and sterilization time is 10～20min;
S33. cream powder mixes: clear paste prepared by step S2 mixes with the fine powder after step S32 sterilizing, makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature≤80 ℃, dry 7～9h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in mixer and always mixed, mix 28～35min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in mixer and mix, the weight ratio of described cream powder and water is 1:0.2～0.4, each incorporation time is 5～10 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content≤7%, make the fat reducing pill for the treatment of hyperlipemia.
In the present invention's formula:
Herba Taxilli: nature and flavor: bitter sweet, flat; Gui Jing: enter liver, kidney channel; Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, a little less than muscles and bones flaccidity, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Control chronic cough, protrusion of the tongue is dizzy.
Radix Puerariae: powder of Radix Puerariae sweet in the mouth cool in nature is pungent, having induces sweat brings down a fever, and promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as have loose bowels.
Rhizoma Dioscoreae: nature and flavor: bitter sweet, flat, nontoxic; Gui Jing: return spleen, lung, kidney channel; Function cures mainly: spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.
Radix Et Rhizoma Rhei: nature and flavor: hardship, cold; Gui Jing: spleen, stomach, large intestine, liver, pericardium channel; Effect: attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances; Cure mainly: excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spits blood, spitting of blood, epistaxis, has blood in stool, hematuria, blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scalds.
Fructus Crataegi: nature and flavor: acid is sweet, tepor; Gui Jing: enter spleen, stomach, Liver Channel; Function cures mainly: helps digestion long-pending, and dissipating blood stasis blood, expelling tenia.Control meat long-pending, lump in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia after-pains in puerperal, lochiorrhea, children's's breast food is stagnated.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, stomach alkane distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain, hyperlipidemia.
Radix Salviae Miltiorrhizae: performance: bitter in the mouth, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.Purposes: for menoxenia due to blood stasis, dysmenorrhea, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal; Angina pectoris, atherosclerosis; Chronic hepatitis, liver cirrhosis, abdominal masses or tumor; Chronic cardiopulmonary disease, bronchial asthma; Blood failing to tonify the heart or heart-fire are partially high, palpitation and restlessness, vexed insomnia.
Flos Carthami: nature and flavor: pungent, temperature.Gui Jing: enter the heart, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Rhizoma Alismatis: nature and flavor: sweet in the mouth, light, cold in nature; Gui Jing: enter kidney, urinary bladder channel; Function cures mainly: promoting diuresis to eliminate damp pathogen, treating stranguria, the main dysuria that expels the heat-evil, the puckery pain of pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission.
Herba Artemisiae Scopariae: meridian distribution of property and flavor: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc.Pharmaceutical research has function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.
Herba Taraxaci: nature and flavor: sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, returns liver, stomach warp.Function cures mainly: control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, jaundice, the puckery pain of dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.
This prescription is according to Chinese Traditional Medicine theory and experience, and in conjunction with modern pharmacology analysis, according to dialectical legislation, the principle of the side of system, screens the new Chinese medicinal formulae forming through long-term clinical practice in accordance with the law.Chinese medicine is without the name of disease of hyperlipidemia mass formed by blood stasis, but the disease prognosis relevant according to its etiology and pathogenesis lapses to, be attributable to the categories such as " dizzy " " pained " " wet sun ", how because surfeit Sorghum vulgare Pers. savoury is crossed stagnation of QI due to depression of the liver, or how wet body fertilizer is, or old prolonged illness, plain body deviation causes deficiency of spleen and stomach, turbid damp obstructing in middle-JIAO, and congestion retardance forms.Though clinical, have excess-heat syndrome, deficiency-cold syndrome minute, common deficiency and excess is held miscellaneous diseases under the arm.Pathogenesis and deficiency and excess for hyperlipemia deficiency of spleen and stomach, dampness, blood stasis are held assorted clinical characters under the arm, draft kidney and spleen invigorating, catharsis blood stasis dispelling, the treatment rule of clearing away heat-damp and promoting diuresis.
Herba Taxilli invigorating the liver and kidney in side, beneficial blood vessels are monarch; Radix Puerariae sending up the lucid YANG, drum noon taste yang-energy rises, Rhizoma Dioscoreae tonifying the spleen and stomach, two medicine spleen invigorating yang invigorating dehumidifying, assist monarch drug Herba Taxilli to play altogether strengthening the body resistance, and the merit of kidney and spleen invigorating is ministerial drug; Radix Et Rhizoma Rhei stasis removing, purging fire and cooling blood, blood circulation promoting and blood stasis dispelling, hawthorn digesting spleen invigorating, blood circulation promoting and blood stasis dispelling, is equipped with the power that Radix Salviae Miltiorrhizae, Flos Carthami strengthen blood circulation promoting and blood stasis dispelling, and Herba Artemisiae Scopariae, Herba Taraxaci clearing away heat-damp and promoting diuresis, be equipped with Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, so that let out under phlegm-damp, turbid pathogen, altogether for assistant makes.Full side's reinforce insufficiency and reduce excessiveness, amounts to kidney and spleen invigorating, catharsis blood stasis dispelling, the effect of clearing away heat-damp and promoting diuresis.
The present invention has the following advantages:
1. each pharmaceutical composition of fat reducing pill of the present invention is mutually collaborative, mutually promotes, and can within short-term, blood fat be dropped to normal level, has kidney and spleen invigorating, catharsis blood stasis dispelling, and the effect of clearing away heat-damp and promoting diuresis, for asthenia of both the spleen and kidney, the turbid blood stasis type hyperlipemia of expectorant;
2. fat reducing pill of the present invention has advantages of that therapeutic effect is good, cure rate is high, has no side effect;
3. the preparation method of fat reducing pill of the present invention is simple to operate, easy to prepare, with low cost.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described, and protection scope of the present invention is not limited to the following stated.
Embodiment 1: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts: Herba Taxilli: 10, Radix Puerariae: 40, Rhizoma Dioscoreae: 10, Radix Et Rhizoma Rhei: 30, Fructus Crataegi: 12, Radix Salviae Miltiorrhizae: 40, Flos Carthami: 6, Rhizoma Alismatis: 8, Herba Artemisiae Scopariae: 35, Herba Taraxaci: 10.
The preparation method of the fat reducing pill of above-mentioned treatment hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 5 times of extraction pot Chinese medicine weight, boiling time is 50min, the amount that adds for the second time drinking water is 3 times of extraction pot Chinese medicine weight, boiling time is 50min, and described decoction for the first time also comprises drug immersion 25min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.24 clear paste, the pressure of described concentrating under reduced pressure is 0.01MPa, and thickening temperature is 70 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of described cold room is 2 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 150 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 115 ℃, and sterilization time is 10min;
S33. cream powder mixes: clear paste prepared by step S2 is placed in trough type mixing machine with fine powder after step S32 sterilizing to be mixed, and makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature is 80 ℃, and dry 7h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in two-dimensional motion mixer and always mixed, mix 28min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in trough type mixing machine and mix, the weight ratio of described cream powder and water is 1:0.2, each incorporation time is 5 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content be 7%, make treatment hyperlipemia fat reducing pill.
Embodiment 2: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts: Herba Taxilli: 45, Radix Puerariae: 15, Rhizoma Dioscoreae: 35, Radix Et Rhizoma Rhei: 10, Fructus Crataegi: 40, Radix Salviae Miltiorrhizae: 15, Flos Carthami: 25 Rhizoma Alismatis: 35, Herba Artemisiae Scopariae: 5, Herba Taraxaci: 30.
The preparation method of the fat reducing pill of above-mentioned treatment hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 7 times of extraction pot Chinese medicine weight, boiling time is 70min, the amount that adds for the second time drinking water is 5 times of extraction pot Chinese medicine weight, boiling time is 70min, and described decoction for the first time also comprises drug immersion 35min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.27 clear paste, the pressure of described concentrating under reduced pressure is 0.15MPa, and thickening temperature is 90 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of described cold room is 5 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 180 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 130 ℃, and sterilization time is 20min;
S33. cream powder mixes: clear paste prepared by step S2 is placed in trough type mixing machine with fine powder after step S32 sterilizing to be mixed, and makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature is 75 ℃, and dry 9h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in two-dimensional motion mixer and always mixed, mix 35min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in trough type mixing machine and mix, the weight ratio of described cream powder and water is 1:0.4, each incorporation time is 10 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content be 6.5%, make treatment hyperlipemia fat reducing pill.
Embodiment 3: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts: Herba Taxilli: 20, Radix Puerariae: 30, Rhizoma Dioscoreae: 15, Radix Et Rhizoma Rhei: 25, Fructus Crataegi: 20, Radix Salviae Miltiorrhizae: 35, Flos Carthami: 10, Rhizoma Alismatis: 25, Herba Artemisiae Scopariae: 15, Herba Taraxaci: 22.
The preparation method of the fat reducing pill of above-mentioned treatment hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 5.5 times of extraction pot Chinese medicine weight, boiling time is 58min, the amount that adds for the second time drinking water is 3.5 times of extraction pot Chinese medicine weight, boiling time is 55min, and described decoction for the first time also comprises drug immersion 28min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.25 clear paste, the pressure of described concentrating under reduced pressure is 0.05MPa, and thickening temperature is 76 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of described cold room is 3 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 160 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 118 ℃, and sterilization time is 14min;
S33. cream powder mixes: clear paste prepared by step S2 is placed in trough type mixing machine with fine powder after step S32 sterilizing to be mixed, and makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature is 70 ℃, and dry 8h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in two-dimensional motion mixer and always mixed, mix 30min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in trough type mixing machine and mix, the weight ratio of described cream powder and water is 1:0.3, each incorporation time is 7 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content be 6%, make treatment hyperlipemia fat reducing pill.
Embodiment 4: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts: Herba Taxilli: 35, Radix Puerariae: 20, Rhizoma Dioscoreae: 25, Radix Et Rhizoma Rhei: 15, Fructus Crataegi: 30, Radix Salviae Miltiorrhizae: 20, Flos Carthami: 18, Rhizoma Alismatis: 15, Herba Artemisiae Scopariae: 23, Herba Taraxaci: 16.
The preparation method of the fat reducing pill of above-mentioned treatment hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 6 times of extraction pot Chinese medicine weight, boiling time is 60min, the amount that adds for the second time drinking water is 4 times of extraction pot Chinese medicine weight, boiling time is 60min, and described decoction for the first time also comprises drug immersion 30min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.26 clear paste, the pressure of described concentrating under reduced pressure is 0.08MPa, and thickening temperature is 82 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of cold room is 4 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 168 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 121 ℃, and sterilization time is 16min;
S33. cream powder mixes: clear paste prepared by step S2 is placed in trough type mixing machine with fine powder after step S32 sterilizing to be mixed, and makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature is 65 ℃, and dry 9h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in two-dimensional motion mixer and always mixed, mix 30min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in trough type mixing machine and mix, the weight ratio of described cream powder and water is 1:0.4, each incorporation time is 8 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content≤7%, make the fat reducing pill for the treatment of hyperlipemia.
Embodiment 5: a kind of fat reducing pill for the treatment of hyperlipemia, and it is comprised of the raw material of following weight parts: Herba Taxilli: 25, Radix Puerariae: 25, Rhizoma Dioscoreae: 20, Radix Et Rhizoma Rhei: 20, Fructus Crataegi: 22, Radix Salviae Miltiorrhizae: 25, Flos Carthami: 13, Rhizoma Alismatis: 18, Herba Artemisiae Scopariae: 17, Herba Taraxaci: 18.
The preparation method of the fat reducing pill of above-mentioned treatment hyperlipemia, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 6.5 times of extraction pot Chinese medicine weight, boiling time is 64min, the amount that adds for the second time drinking water is 4.5 times of extraction pot Chinese medicine weight, boiling time is 62min, and described decoction for the first time also comprises drug immersion 32min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.24 clear paste, the pressure of described concentrating under reduced pressure is 0.1MPa, and thickening temperature is 85 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of cold room is 5 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 175 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 125 ℃, and sterilization time is 18min;
S33. cream powder mixes: clear paste prepared by step S2 is placed in trough type mixing machine with fine powder after step S32 sterilizing to be mixed, and makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Baking temperature is 80 ℃, and dry 9h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in two-dimensional motion mixer and always mixed, mix 32min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in trough type mixing machine and mix, the weight ratio of described cream powder and water is 1:0.2, each incorporation time is 9 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content≤7%, make the fat reducing pill for the treatment of hyperlipemia.
Beneficial effect of the present invention is below described by experiment:
One, case selection
Choose 437 routine patients, serum total cholesterol is greater than 6.00mmol/L and/or triglyceride is greater than 1.71mmol/L, male's 303 examples wherein, women's 134 examples, age distribution 41-82 year, 59.33 years old mean age.
Complication: 437 routine patient's major parts have different and deposit disease, meter coronary heart disease 121, hypertension 35, diabetes 33, chronic bronchitis inflammation 33, pulmonary heart disease 18, hypertensive cardiopathy 19, other are 177 years old.
From Syndrome Differentiation of Traditional Chinese Medicine, excess-heat type 91 examples account for 20.82%, and asthenic cold type 101 examples account for 23.11%, and double assorted type 241 examples of deficiency and excess account for 56.06%.
Two, treatment and observational technique
1. all object is stopped using for 10-14 days before treatment, and other may affect blood lipid level medicine, and vegetarian diet three days, gets fasting blood early morning, with enzymatic assays serum cholesterol, and triglyceride, high density lipoprotein, and make routine physical examination;
By patient with minutes two groups at random of 2:1, i.e. treatment group 324 examples, matched group 113 examples, treatment group is taken the fat reducing pill 4gt.i.d of embodiment 5 preparations; Matched group is taken hypogastric lipid-lowering pill (Guangdong Hongxing Group Co., Ltd. Hongxing Pharmaceutical Factory) 2gb.i. and all be take 30 days as a course for the treatment of, as the case may be medication 1-2 course for the treatment of, finishes all to check above-mentioned related index each course for the treatment of;
3. curative effect judgement:
Clinical recovery: a. transference cure or substantially disappearance; B. two above improvements of sign; C.TCTG transfers to normally; D. relevant and deposit disease leading indicator and significantly take a turn for the better.
Effective: a. symptom obviously alleviates; B. two of signs are above takes a turn for the better, without or only one add severe one; C.TCTG has one to transfer to normally, another decline one-level; D. relevant and deposit disease leading indicator and take a turn for the better.
Effective: a. symptom obviously alleviates; B. two of signs are above takes a turn for the better, without or only one add severe one; C.TCTG has one to transfer to normally, another decline one-level; D. relevant and deposit disease leading indicator and take a turn for the better.
Invalid: above four all do not reach efficiency index, add severe one even.
4. result:
A. after two groups of courses for the treatment of of taking medicine, all symptom, sign, chemical examination and blood fat are had to impact, synthetic determination curative effect, treatment group: clinic control 55, remarkable 95, effective 113, invalid 63, total effective rate is 80.56%; Matched group: clinic control 16, effective 34, effective 42, invalid 21, total effective rate 81.42, the results are shown in Table 1;
Table 1. treatment group and the comparison of matched group curative effect
B. two groups of common symptons are as: the variation of integration before and after the futile treatment such as dizzy, headache, precordial pain, cardiopalmus, soreness of the waist and knees (symptom integral by by light to heavily remembering 0-4 minute Pyatyi), with RIDIT, analyze, two groups are compared before and after a course of therapy, difference is all very remarkable, (the equal <0.01 of P is in Table 2,3) and before both: forward and backward: rear all no significant differences, two groups of effects are similar.
The routine symptom of table 2. treatment group 324 Ridit that scores analyzes
The table 3. matched group symptom Ridit that scores analyzes
C. we introduce TC, TG, tri-laboratory dosage guideline of HDL-c judge the lipid-lowering effect of two kinds of medicines to observer.Observed in addition the impact on blood glucose.Result shows: treatment group is taken medicine a course for the treatment of, serum cholesterol declines to some extent, statistical procedures significant difference (p<0.05), wherein 88 examples are former in normal person (>6mml), take one course for the treatment of of fat reducing pill, difference is (p<0.01) very significantly; After matched group one course of therapy, serum cholesterol obviously reduces (p<0.01), in Table 4.
The variation of serum cholesterol before and after table 4. liang group treatment
After one course for the treatment of: two groups of serum levels of triglyceride are all decreased significantly (p<0.001); HDL-c has rising (treatment group p<0.01, matched group p<0.05) in various degree, in Table 5,6.
Before and after table 5. liang group treatment, triglyceride changes
Before and after table 6. liang group treatment, HDL-c changes
Zhong Youliangge unit of Liu Ge observation unit find a few patients take medicine after blood sugar increasing, these patients all have diabetes and deposit, but treat, take medicine a course for the treatment of, and fasting glucose has 5.5607 ± 1.7394 to be down to 5.4075 ± 1.3815 (mmol/L), and matched group is without significant change, in Table 7.
Before and after table 7. liang group treatment, fasting glucose changes
D.San Jia hospital is to two groups of observation and comparisons that carry out two curative effects, a course for the treatment of of treatment group 155 example, p>0.05 no significant difference, but two the course for the treatment of p<0.05 difference have significance; Matched group all has obvious decline (p<0.01) two courses for the treatment of.
The cholesterol that table 8. fat reducing pill treated for two courses for the treatment of changes
Relatively front with treatment: * P<0.05**p<0.01
After two groups of triglyceride treatments, decline all significantly (P<0.05), more remarkable (p<0.01) (in Table 9) after second course for the treatment of.But two groups of serum hdl-c and fasting glucose be no matter after one or two courses for the treatment of, difference is remarkable (p>0.05) (table 10,11) all
The triglyceride that table 9. fat reducing pill treated for two courses for the treatment of changes
Relatively front with treatment: * P<0.05**p<0.01
The HDL-c that table 10. fat reducing pill treated for two courses for the treatment of changes
Relatively front with treatment: * P<0.05
The fasting glucose that table 11. fat reducing pill treated for two courses for the treatment of changes
Relatively front with treatment: * P<0.05
E. with body weight and obesity index, observe two medicines and have or not fat-reducing effect one course for the treatment of, result shows: after treatment group and treatment of control group body weight decline respectively 0.71,0.81kg (table 12).With comparing difference before and after treatment very significantly (p<0.01).But with obesity index (index=body weight kg/ height m
2* 100%) >25% is overweight, 20-24% for normal, <20% is for not enough.Add up respectively the variation of every shared number of cases, result shows: treatment group superduty is reduced to 76 examples by 87 examples, and normal person increases to 213 examples by 202 examples, and not enough person is unchanged; Matched group superduty is reduced to 20 examples by 28 examples, and normal person increases to 79 examples by 65, and not enough person is kept to 29 examples by 35 examples, but two groups are analyzed no significant difference with Ridit.
The variation of table 12. liang group treatment forward backward averaging body weight
F. from Syndrome Differentiation of Traditional Chinese Medicine (table 13), the routine excess-heat type for the treatment of group 66 clinic control 7, effective 19, effective 22, invalid 18, total effective rate 72.72%, 70 routine deficiency-cold syndrome effective percentage 78.57%, statistical procedures no significant difference between the double assorted type effective percentage 84.24% of 184 routine deficiency and excesss is various, the various significant difference that also has no of matched group.Illustrate that two medicines may be to each pattern of syndrome extensively treating.
Table 13. liang group Syndrome Differentiation of Traditional Chinese Medicine curative effect comparison
G. two groups of patients are after one or two courses for the treatment of of taking medicine, 4 routine erythra, urticaria, appearance one property crossed serum albumin decline (decreased average 0.9g/L have been observed, be matched group), another experiment hospital finds that 4 examples have the property crossed a serum SGPT rising (matched group), continue to take medicine and recover normal, in addition also have small part patient to take medicine and within first week, occur abdominal distention, upper abdominal pain, diarrhoea etc., after reducing dosage or short-term drug withdrawal, disappear, do not affected the course for the treatment of.
H. by contrasting the take medicine variation of front and back of the hemorheology of two groups of cases, result shows: two kinds of medicines, to indexs such as plasma viscosity, packed cell volume, platelet adhesion rates, all have no significant effect (p>0.05).
I. table 14, shows that two medical materials, to (light, in, severe) serum cholesterol rising person in various degree, all have the effect of obvious reduction, and the curative effect of two kinds of medicines is similar, no significant difference.
The impact of table 14. liang medicine on high-cholesterol disease in various degree
Claims (4)
1. a fat reducing pill for the treatment of hyperlipemia, is characterized in that, it is comprised of the raw material of following weight parts:
Herba Taxilli: 10～45, Radix Puerariae: 15～40, Rhizoma Dioscoreae: 10～35,
Radix Et Rhizoma Rhei: 10～30, Fructus Crataegi: 12～40, Radix Salviae Miltiorrhizae: 15～40,
Flos Carthami: 6～25, Rhizoma Alismatis: 8～35, Herba Artemisiae Scopariae: 5～35,
Herba Taraxaci: 10～30.
2. a kind of fat reducing pill for the treatment of hyperlipemia as claimed in claim 1, is characterized in that, it is comprised of the raw material of following weight parts:
Herba Taxilli: 20～35, Radix Puerariae: 20～30, Rhizoma Dioscoreae: 15～25,
Radix Et Rhizoma Rhei: 15～25, Fructus Crataegi: 20～30, Radix Salviae Miltiorrhizae: 20～35,
Flos Carthami: 10～18, Rhizoma Alismatis: 15～25, Herba Artemisiae Scopariae: 15～23,
Herba Taraxaci: 16～22.
3. a kind of fat reducing pill for the treatment of hyperlipemia as claimed in claim 1, is characterized in that, it is comprised of the raw material of following weight parts:
Herba Taxilli: 25, Radix Puerariae: 25, Rhizoma Dioscoreae: 20,
Radix Et Rhizoma Rhei: 20, Fructus Crataegi: 22, Radix Salviae Miltiorrhizae: 25,
Flos Carthami: 13, Rhizoma Alismatis: 18, Herba Artemisiae Scopariae: 17,
Herba Taraxaci: 18.
4. a kind of preparation method for the treatment of the fat reducing pill of hyperlipemia as described in any one in claim 1-3, is characterized in that, it comprises the following steps:
S1. weigh: by above-mentioned formula proportion, take each raw material, and Herba Taxilli, Radix Puerariae, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei, Fructus Crataegi, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci nine taste medical materials are divided into respectively to two parts of equiponderant A, B, standby;
S2. the preparation of clear paste:
S21. extract: A part medical material is decocted with water twice, the amount that adds for the first time drinking water is 5～7 times of extraction pot Chinese medicine weight, boiling time is 50～70min, the amount that adds for the second time drinking water is 3～5 times of extraction pot Chinese medicine weight, boiling time is 50～70min, and described decoction for the first time also comprises drug immersion 25～35min before decoction; After decocting, mix the medicinal liquid of twice, and admixing medical solutions is pumped in medicinal liquid storage tank;
S22. concentrated: medicinal liquid is carried out to concentrating under reduced pressure from pumping in dual-effect concentrator in medicinal liquid storage tank, be concentrated into relative density and be 1.24～1.27 clear paste, the pressure of described concentrating under reduced pressure is 0.01～0.15MPa, and thickening temperature is 70～90 ℃;
S23. receive cream: clear paste is collected in turnover barrel, lets cool to proceeding to cold room after room temperature temporaryly, the temperature of described cold room is 2～5 ℃;
S3. the preparation of cream powder:
S31. pulverize: B part medical material and Flos Carthami powder are broken into the fine powder that particle diameter is 150～180 μ m;
S32. sterilizing: the fine powder after pulverizing is carried out to moist heat sterilization, and sterilising temp is 115～130 ℃, and sterilization time is 10～20min;
S33. cream powder mixes: clear paste prepared by step S2 mixes with the fine powder after step S32 sterilizing, makes uniform medicine piece;
S34. dry: medicine piece is placed in heated-air circulation oven, is dried to without soft yolk, system gets dry extract; Described baking temperature≤80 ℃, dry 7～9h turns over medicine one time every 4h in dry process;
S35. pulverize and always mix: dry cream being ground into fine powder with pulverizer, crossing 100 mesh sieves, the fine powder after sieving is dropped in mixer and always mixed, mix 28～35min, make cream powder;
S4. pill: cream powder and water are added and carries out gradation in mixer and mix, the weight ratio of described cream powder and water is 1:0.2～0.4, each incorporation time is 5～10 minutes, make soft material, soft material is added in medicine refining machine and refined, then with pellet processing machine, carry out pill, in pelletizing process, with ethanol, make lubricant, and be dried to water content≤7%, make the fat reducing pill for the treatment of hyperlipemia.
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| CN104606461A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Lipid-lowering agent for non-alcoholic fatty liver and preparation method thereof |
| CN104606463A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for regulating moderate fatty liver and preparation method thereof |
| CN104606462A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for conditioning alcoholic fatty liver and preparation method of medicine |
| CN104623137A (en) * | 2015-02-06 | 2015-05-20 | 刘延玲 | Traditional Chinese medicine composition capable of invigorating pulse and reducing adipose for treating moderate fatty liver and preparation method of composition |
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| CN104606461A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Lipid-lowering agent for non-alcoholic fatty liver and preparation method thereof |
| CN104606463A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for regulating moderate fatty liver and preparation method thereof |
| CN104606462A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for conditioning alcoholic fatty liver and preparation method of medicine |
| CN104623137A (en) * | 2015-02-06 | 2015-05-20 | 刘延玲 | Traditional Chinese medicine composition capable of invigorating pulse and reducing adipose for treating moderate fatty liver and preparation method of composition |
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Application publication date: 20140917 |