CN1034136A - The production method of compound Chinese medicinal preparation " Sang Gedan " - Google Patents
The production method of compound Chinese medicinal preparation " Sang Gedan " Download PDFInfo
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- CN1034136A CN1034136A CN 88100254 CN88100254A CN1034136A CN 1034136 A CN1034136 A CN 1034136A CN 88100254 CN88100254 CN 88100254 CN 88100254 A CN88100254 A CN 88100254A CN 1034136 A CN1034136 A CN 1034136A
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Abstract
The invention belongs to a kind of production method of preventing and treating the compound Chinese medicinal preparation of hyperlipemia, arteriosclerosis, coronary heart disease.This method be with Chinese medicines such as Herba Taxilli, Radix Puerariae, Radix Salviae Miltiorrhizaes by certain formula proportion, produce fine powder through crushing screening, coarse grain is made concentrated solution with water infiltration, decoction, filtration.The general ball of the bonding fine powder of reuse concentrated solution is made " Sang Gedan " pill.Its stable preparation process, quality standard meet that " Chinese pharmacopoeia regulation is prevented and treated hyperlipemia, arteriosclerosis, coronary heart disease curative effect height, and is safe and reliable, has no side effect.
Description
The invention belongs to a kind of production method of compound Chinese medicinal preparation.
Hyperlipemia is the pathological change that one or more dyslipidemias increase in the blood of human body, often can cause serious diseases such as atherosclerosis, coronary heart disease, hypertension.Therefore prevent and treat hyperlipemia and become a domestic and international medical circle important topic anxious to be solved.
At present both at home and abroad the blood lipid-lowering medicine that uses has clofibrate and derivant thereof, nicotinic acid, cholestyramine, fenofibrate, bezalip, dextran sulfate sodium, Elastase, arteries and veins health, oryzanol, vitamin E, blood fat reducing equality, though certain curative effect is arranged, but toxic and side effects such as digestive tract discomfort, hepatic and renal function injure, leukocyte decline and bleeding tendency are arranged, and curative effect is not consolidated, and knock-on is arranged after the drug withdrawal.Clofibrate also can make cholelithiasis, pulmonary infarction, anginal increasing.The domestic extensive use of Chinese medicine blood fat reducing, folk prescription has Rhizoma Alismatis tablets of reducing blood fat, SHANZHAN JIANGZHI PIAN, Herba Taxilli electuary, artificial aweto, Radix Oenotherae erythrosepalae oil, Pollen Typhae, rhubarb powder, Hirudo powder, Radix Camelliae sinensis, Bulbus Allii quintessence oil, injection of Radix Bupleuri, royal jelly glue
, Herba bromi japonici, Semen phaseoli radiati powder, the former powder of Pleurotus ostreatus etc.; Compound recipe has JIANGZHILING, melt hat soup, flat ester is peaceful, fat reducing pill, compound antihyperglycemic sheet, hypogastric lipid-lowering pill etc.Above-mentioned Chinese medicine preparation, most curative effects are not high, without animal model experiment, lack the control of pharmacodynamics and toxicologic index and quality standard, need further investigate.
The object of the present invention is to provide knock-on and the not high weakness of above-mentioned Chinese medicine curative effect after a kind of toxic and side effects that can overcome above-mentioned Western medicine, the drug withdrawal, and have the production method of the compound Chinese medicinal preparation of preventing and treating hyperlipemia, arteriosclerosis, coronary heart disease " Sang Gedan " of highly effective and safe.
The production method main points of " Sang Gedan " are: it is standby that 120 mesh sieves were pulverized in 7 flavor medicines mixing such as Herba Taxilli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Dioscoreae, Rhizoma Alismatis, Herba Taraxaci, Radix Et Rhizoma Rhei.It is standby that Flos Carthami was pulverized 120 mesh sieves separately.The above-mentioned 8 flavor coarse grain of medicines and Herba Artemisiae Scopariae, Radix Puerariae, Poria, the Radix Polygoni Multiflori decocted together to produce concentrated solution standby.Get above-mentioned 8 flavor medicine mixing fine powders and concentrated solution and put general ball jar pterygium in inner canthus ball.
The above-mentioned ratio of medicine in prescription of respectively distinguishing the flavor of is advisable in following scope: Herba Taxilli 10.23～17.04%, Radix Salviae Miltiorrhizae 10.23～17.04%, Fructus Crataegi 8.52～14.20%, Rhizoma Dioscoreae 6.82～11.36%, Herba Taraxaci 3.41～5.68%, Rhizoma Alismatis 5.11～8.52%, Radix Et Rhizoma Rhei 1.70～2.84%, Flos Carthami 5.11～8.52%, Herba Artemisiae Scopariae 3.41～5.68%, Radix Puerariae 10.23～17.04%, Poria 6.82～11.36%, the Radix Polygoni Multiflori 3.41～5.68%.
The preparation method of above-mentioned concentrated solution is: above-mentioned 8 flavor medicated powder are broken, cross the coarse grain behind 120 mesh sieves and Herba Artemisiae Scopariae, Radix Puerariae, Poria, the Radix Polygoni Multiflori of not pulverizing used water infiltration 1 hour together, decoct secondary, each 1 hour.Amount of water is 5-7 times of dose for the first time, is for the second time 4-6 times of dose.The filtrate of twice decoction is merged, and heating concentrates and forms.
The method of above-mentioned general ball is: whole fine powder mix homogeneously of getting 4/5ths and above-mentioned 7 flavor medicines of Flos Carthami fine powder.Earlier play mothers and sons with the bonding fine powder of an amount of concentrated solution, start general ball jar with the speed that per minute 100 changes, spray medicinal liquid with aerosol apparatus to mothers and sons, make it evenly be sprinkled into an amount of fine powder after moistening, treat that fine powder sticks to the mothers and sons surface equably, spray liquor is sprinkled into fine powder again.Like this repeatable operation, medicated powder has been spread till.The screening pill makes uniformity, with the ubiquitous pill skin of 1/5th Flos Carthami fine powders of remainder, and 60 ℃ of oven dry, shady and cool ventilation place drying is put in polishing, packing, airtight preservation.
The method of this general ball can also adopt the whole fine powder mix homogeneously of 8 flavor medicines, uses the method general ball identical with above-mentioned technology, and its curative effect is not a coat with the Flos Carthami fine powder just with aforesaid consistent, and is pleasing not as the former in appearance.
By formula proportion provided by the invention, also medicine can be made tablet, powder, electuary, or make injection through darker processing refinement.
The compound Chinese medicinal preparation that method provided by the invention is made " Sang Gedan " has the following advantages:
1. the prescription composition is fixing, stable preparation process, and quality standard meets " Chinese pharmacopoeia regulation.
2. curative effect is higher, and is safe and reliable, has no side effect:
1. treat the thousands of examples of hyperlipemia, systematic observation 200 examples, cholesterol reducing effective percentage 92.6%, decline average 68mg/dl, rate of descent 22.5%; Triglyceride reducing effective percentage 91.3%, decline average 146mg/dl, rate of descent 39.4%; Beta Lipoprotein effective percentage 93.6% falls, decline average 217mg/dl, rate of descent 28.8%.
2. evident in efficacy to malignant hyperlipemia.Systematic observation 160 examples, curative effect is consistent with above-mentioned hyperlipemia.At present domestic and international rare report is to pernicious (severe) hyperlipemia curative effect medicine preferably.
3. the effect that has high density lipoprotein increasing, effective percentage 89.5%, rising average 20.2mg/dl, rate of rise 43.6%.Seldom report medicine at present both at home and abroad with this kind effect.
4. late result is better.Follow up a case by regular visits to 50 examples, average withdrawal time 12.6 months, lipid determination compare zero difference (P＞0.05) when finishing with treatment, show efficacy consolidation.
5. curative effect does not have regional disparity.To being distributed in 40 routine hyperlipemia clinical verifications of 10 provinces and cities such as Jilin, the Inner Mongol, Hebei, Henan, Anhui, Jiangsu, Guangdong, Sichuan, Yunnan and Beijing, curative effect is observed consistent with the court.
3. zoopery confirms that this medicine has the blood fat reducing speckle removing concurrently and removing thrombosis two acts on greatly, has pharmacodynamics, pathology and the hemorheology basis of atherosclerosis of preventing and treating and coronary heart disease.
4. have kidney and spleen invigorating, the effect of the fat-reducing that helps digestion, activating blood circulation to dissipate blood stasis, slow down aging, be comparatively ideal compound Chinese medicinal preparation.
Embodiments of the invention:
Get Herba Taxilli 350 gram, Radix Salviae Miltiorrhizae 250 grams, Fructus Crataegi 300 grams, Rhizoma Dioscoreae 200 grams, Rhizoma Alismatis 150 grams, Herba Taraxaci 100 grams, Radix Et Rhizoma Rhei 40 grams, mix that to pulverize 120 mesh sieves standby.Getting Flos Carthami 160 gram, to pulverize 120 mesh sieves separately standby.The coarse grain of above-mentioned 8 flavor medicines is used water infiltration 1 hour with Radix Puerariae 300 grams, Herba Artemisiae Scopariae 120 grams, Poria 150 grams, the Radix Polygoni Multiflori 80 grams, decoct secondary.For the first time amount of water is 7 times of medication amount, decocts 1 hour, gets its filtrate; For the second time amount of water is 5 times of medication amount, decocts 1 hour, gets its filtrate; Twice filtrate is merged heating to be concentrated standby.The Flos Carthami fine powder of getting the above-mentioned 7 flavor whole fine powders of medicine and 4/5ths mixes, and is binding agent with above-mentioned concentrated solution, puts general ball in the general ball jar.On the basis of playing good mothers and sons, spraying liquid alternately repeats with the powder that spreads pesticides.General ball jar rotating speed is that per minute 100 changes.The screening pill makes uniformity, with the ubiquitous pill skin of 1/5th Flos Carthami fine powders of remainder, and 60 ℃ of oven dry, shady and cool ventilation place drying is put in polishing, packing, airtight preservation.
The foregoing description only selects for use 9 flavor medicines such as Herba Taxilli, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Alismatis, Herba Artemisiae Scopariae, Herba Taraxaci, Flos Carthami, Radix Et Rhizoma Rhei to make pill by preceding method, has also obtained similar curative effect.
Claims (4)
1, a kind of production method of preventing and treating the compound Chinese medicinal preparation " Sang Gedan " of hyperlipemia, arteriosclerosis, coronary heart disease is characterized in that:
A. with Herba Taxilli, Radix Salviae Miltiorrhizae, Fructus Crataegi, Rhizoma Dioscoreae, Rhizoma Alismatis, Herba Taraxaci, Radix Et Rhizoma Rhei mixing crushing screening, the independent crushing screening of Flos Carthami, the above-mentioned 8 flavor coarse grain of medicines and Herba Artemisiae Scopariae, Radix Puerariae, Poria, the Radixs Polygoni Multiflori add water infiltration, decoction, filtration together, concentrate, with the general ball of fine powder of the bonding aforementioned 8 flavor medicines of concentrated solution
B. the above-mentioned ratio of medicine in prescription of respectively distinguishing the flavor of is: Herba Taxilli 10.23～17.04%, Radix Salviae Miltiorrhizae 10.23～17.04%, Fructus Crataegi 8.52～14.20%, Rhizoma Dioscoreae 6.82～11.36%, Rhizoma Alismatis 5.11～8.52%, Herba Artemisiae Scopariae 3.41～5.68%, Herba Taraxaci 3.41～5.68%, Radix Et Rhizoma Rhei 1.70～2.84%, Flos Carthami 5.11～8.52%, Radix Puerariae 10.23～17.04%, Poria 6.82～11.36%, the Radix Polygoni Multiflori 3.41～5.68%.
2, press the production method of claim 1 described " Sang Gedan ", the preparation that it is characterized in that concentrated solution is that aforementioned 8 flavor medicated powder is broken after sieving coarse grain and Herba Artemisiae Scopariae, Radix Puerariae, Poria, the Radixs Polygoni Multiflori were used water infiltration 1 hour together, decocts secondary, each 1 hour, merging filtrate, heating concentrates and forms.
3, by the production method of claim 1 described " Sang Gedan ", it is characterized in that general ball is with the bonding fine powder of concentrated solution, in 4/5ths ubiquitous balls of Flos Carthami fine powder, / 5th ubiquitous balls are as coating, play earlier good mothers and sons, spray medicinal liquid to mothers and sons, make it evenly moistening after, be sprinkled into an amount of fine powder, treat that fine powder sticks to the mothers and sons surface equably, spray liquor is sprinkled into fine powder again, so alternately repeat, the general one-tenth of pill back is with 60 ℃ of oven dry.
4, by the production method of claim 1 described " Sang Gedan ", it is characterized in that with Herba Taxilli, Radix Puerariae, Radix Salviae Miltiorrhizae be main formula, suitably select for use all the other 9 flavor medicines all can make compound Chinese medicinal preparation with similar curative effect.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88100254 CN1029081C (en) | 1988-01-15 | 1988-01-15 | Productive method for Chinese Cpd. medicine "Sang-ji-Dan" |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88100254 CN1029081C (en) | 1988-01-15 | 1988-01-15 | Productive method for Chinese Cpd. medicine "Sang-ji-Dan" |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1034136A true CN1034136A (en) | 1989-07-26 |
| CN1029081C CN1029081C (en) | 1995-06-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88100254 Expired - Fee Related CN1029081C (en) | 1988-01-15 | 1988-01-15 | Productive method for Chinese Cpd. medicine "Sang-ji-Dan" |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050756C (en) * | 1994-06-16 | 2000-03-29 | 傅正和 | Viscosity-reducing and antithrombotic tablet and its producing technology |
| CN1055852C (en) * | 1996-12-18 | 2000-08-30 | 张继春 | Wine for reducing blood-pressure |
| CN1063649C (en) * | 1997-09-26 | 2001-03-28 | 操瑞明 | Red ginseng and hawthorn fruit health-care wine |
| CN1079253C (en) * | 1998-12-24 | 2002-02-20 | 赵徕淋 | Medicinal oil for dredging channels and collaterals of heart and brain and its preparing process |
| CN104042847A (en) * | 2014-07-03 | 2014-09-17 | 成都九芝堂金鼎药业有限公司 | Lipid-lowering pills for treating hyperlipidaemia and preparation method thereof |
| CN104383269A (en) * | 2014-12-08 | 2015-03-04 | 济南舜景医药科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease |
| CN104606461A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Lipid-lowering agent for non-alcoholic fatty liver and preparation method thereof |
| CN104606462A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for conditioning alcoholic fatty liver and preparation method of medicine |
| CN104606463A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for regulating moderate fatty liver and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1070375C (en) * | 1997-09-15 | 2001-09-05 | 武汉博海生物工程有限公司 | Emulsion for lowering blood-lipid, and method for preparing same |
-
1988
- 1988-01-15 CN CN 88100254 patent/CN1029081C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1050756C (en) * | 1994-06-16 | 2000-03-29 | 傅正和 | Viscosity-reducing and antithrombotic tablet and its producing technology |
| CN1055852C (en) * | 1996-12-18 | 2000-08-30 | 张继春 | Wine for reducing blood-pressure |
| CN1063649C (en) * | 1997-09-26 | 2001-03-28 | 操瑞明 | Red ginseng and hawthorn fruit health-care wine |
| CN1079253C (en) * | 1998-12-24 | 2002-02-20 | 赵徕淋 | Medicinal oil for dredging channels and collaterals of heart and brain and its preparing process |
| CN104042847A (en) * | 2014-07-03 | 2014-09-17 | 成都九芝堂金鼎药业有限公司 | Lipid-lowering pills for treating hyperlipidaemia and preparation method thereof |
| CN104383269A (en) * | 2014-12-08 | 2015-03-04 | 济南舜景医药科技有限公司 | Traditional Chinese medicine composition for treating coronary heart disease |
| CN104606461A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Lipid-lowering agent for non-alcoholic fatty liver and preparation method thereof |
| CN104606462A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for conditioning alcoholic fatty liver and preparation method of medicine |
| CN104606463A (en) * | 2015-02-06 | 2015-05-13 | 刘延玲 | Medicine for regulating moderate fatty liver and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1029081C (en) | 1995-06-28 |
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