CN104001044A - Traditional Chinese medicine composition treating hyperlipidemia - Google Patents
Traditional Chinese medicine composition treating hyperlipidemia Download PDFInfo
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- CN104001044A CN104001044A CN201410187237.5A CN201410187237A CN104001044A CN 104001044 A CN104001044 A CN 104001044A CN 201410187237 A CN201410187237 A CN 201410187237A CN 104001044 A CN104001044 A CN 104001044A
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Abstract
A disclosed traditional Chinese medicine composition treating hyperlipidemia is prepared from the following raw materials in parts by weight: 100 parts of hedyotis diffusa, 60 parts of orostachys fimbriatus, 40 parts of semen cassiae, 85 parts of broom cypress fruit, 30 parts of cacumen platycladi, 20 parts of clover, 125 parts of fructus forsythiae, 160 parts of coptis, 120 parts of radix glehniae, 150 parts of raw radix polygoni multiflori, 120 parts of yerbadetajo herb, 105 parts of bitter apricot kernel, 60 parts of olibanum, 120 parts of black soybean hull, 150 parts of eucommia, 150 parts of radix paeoniae rubra, 60 parts of corn silk, 100 parts of cirsium japonicum, 120 parts of rhizoma alismatis, 150 parts of cortex lycii, 100 parts of ligusticum wallichii, 120 parts of rose, 70 parts of radix asparagi, 95 parts of alga, 45 parts of dark plum, 80 parts of rhizoma atractylodis, 100 parts of Chinese magnoliavine, 120 parts of radix stephaniae tetrandrae, 150 parts of ardisia japonica, 120 parts of cornu cervi degelatinatum and 100 parts of radix glycyrrhiza. The above bulk drugs are subjected to discrimination and compatibility, and together give play to efficacy of soothing liver and moving qi and activating blood, tonifying spleen and benefiting stomach and resolving accumulation, removing heat to cool blood and dissipate stasis, tonifying kidney and engendering fluid and moistening intestines, and has substantial treatment effect on hyperlipidemia patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of hyperlipemia, belong to the field of Chinese medicines.
Background technology
Hyperlipemia refers to that blood lipid level is too high, can directly cause the disease of some serious harm healths, as atherosclerosis, coronary heart disease, pancreatitis etc.Hyperlipemia can be divided into constitutional and Secondary cases two classes.Constitutional is with congenital and hereditary relevant, due to single-gene defect or polygenes defect, make to participate in receptor, enzyme or the apolipoprotein caused by abnormal of lipoprotein transhipment and metabolism, or due to environmental factors (diet, nutrition, medicine) with cause by unknown mechanism.Secondary cases is multiple is born in metabolic disorders (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal cortex function are hyperfunction), or with other factors as, age, sex, season, drink, smoking, diet, physical exertion, emotional activity etc. is relevant.To be lipid deposit caused xanthoma and lipid deposits caused arteriosclerosis at blood vessel endothelium in intradermal to its main clinical manifestation.Although hyperlipemia can cause xanthoma, its incidence rate is also not bery high; And atherosclerotic generation and development are a kind of slowly progressive processes.Therefore most of patients non-evident sympton and abnormal sign under normal conditions.Many people just find that there is serum lipoprotein level while carrying out blood biochemical check due to other reasons to raise.Long-term dyslipidemia can cause atherosclerosis, increase the M & M of cardiovascular and cerebrovascular disease.Along with living standard raising and lifestyle change, the prevalence of China's dyslipidemia obviously raises.According to < < Chinese residents nutrition and Health Situation (2004) > >, China adult blood fat abnormality prevalence rate is 18.6%, estimates number of patients 1.6 hundred million.
Control dyslipidemia to life-saving, improve the quality of living significant.Hyperlipemia treatment one is: dietetic therapy, restriction food rich in fat intake, the 2nd: the custom of making the life better, as motion exercise, smoking cessation, limit wine etc., the 3rd: Drug therapy, as Statins, the special class of shellfish, nicotinic acid class, resinae etc., the 4th: other treatment measure, as plasma purification treatment, operative treatment and gene therapy etc.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of hyperlipemia.
The technology used in the present invention solution is:
A kind of Chinese medicine composition for the treatment of hyperlipemia, it is to be made by the crude drug of following weight parts proportioning: 100 parts of Herba Hedyotidis Diffusaes, 60 parts of Herba Orostachyos, 40 parts of Semen Cassiaes, 85 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 20 parts of Herba Medicaginiss, 125 parts of Fructus Forsythiaes, 160 parts of Rhizoma Coptidis, 120 parts of RADIX GLEHNIAE from Liaoning of China, 150 parts of Radix Polygoni Multifloris, 120 parts of Herba Ecliptaes, 105 parts of Semen Armeniacae Amarums, 60 parts of Olibanums, 120 parts of Testa sojae atricolors, 150 parts of the Cortexs Eucommiae, 150 parts of Radix Paeoniae Rubra, 60 parts of Stigma Maydis, 100 parts of Radix Cirsii Japonicis, 120 parts of Rhizoma Alismatis, 150 parts of Cortex Lycii, 100 parts of Rhizoma Chuanxiongs, 120 parts of Flos Rosae Rugosaes, 70 parts of Radix Asparagis, 95 parts of Sargassums, 45 parts of Fructus Mumes, 80 parts of Rhizoma Atractylodis, 100 parts of Fructus Schisandrae Chinensis, 120 parts of Radixs Stephaniae Tetrandrae, 150 parts of PINGDIMU, 120 parts of Cornu Cervi Degelatinatums, 100 parts, Radix Glycyrrhizae.
The preparation method of above-mentioned Chinese medicine, comprises the following steps:
(1) by above-mentioned weight portion proportioning, take respectively 30 crude drug simply;
(2) get Herba Hedyotidis Diffusae, Herba Orostachyos, Semen Cassiae, the Fructus Kochiae, Herba Ecliptae, Semen Armeniacae Amarum, Olibanum, Testa sojae atricolor, the Cortex Eucommiae, Radix Paeoniae Rubra, Stigma Maydis, Cornu Cervi Degelatinatum, Radix Glycyrrhizae, add 6 times of water gagings and decoct twice, each 1.5 hours, filter, merging filtrate, be evaporated to relative density 1.10-1.15 (60 ℃), add ethanol and make to reach 60%, standing over night containing alcohol amount, draw supernatant, be evaporated to the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure, gets dry extract one;
(3) get again residue 18 taste crude drug, add 8 times of water gagings and decoct twice, each 1.5 hours, filter, merging filtrate, be evaporated to relative density 1.10-1.15 (60 ℃), add ethanol and make to reach 60%, standing over night containing alcohol amount, draw supernatant, be evaporated to the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure, gets dry extract two;
(4) get above-mentioned dry cream one and dry cream two, pulverize respectively, mix, then add dextrin, dry cream one is 1: 2～1: 5 with the gross weight of dry cream two and the ratio that dextrin adds weight, and mix homogeneously is granulated, dry, encapsulated, obtains.
Pharmacology and the beneficial effect of selected each crude drug of the present invention are as follows:
Herba Hedyotidis Diffusae: micro-hardship, micro-sweet, is slightly cold; GUIXIN, liver, spleen channel; Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema;
Herba Orostachyos: heat-clearing and toxic substances removing, hemostasis, dampness removing, detumescence;
Semen Cassiae: sweet in the mouth, salty, bitter, cold nature; Return liver, large intestine channel; The function of tool clearing away heat to improve acuity of vision, loosening bowel to relieve constipation;
The Fructus Kochiae: cold in nature, acrid in the mouth, hardship; Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching;
Cacumen Platycladi: nature and flavor are pained, cold; Enter the heart, liver, large intestine channel; There is removing heat from blood, hemostasis, wind-damp dispelling, the effect of loose toxic swelling;
Herba Medicaginis: there is the effect of interior-heat clearly;
Fructus Forsythiae: bitter in the mouth, cold nature; Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating;
Rhizoma Coptidis: there is heat clearing and damp drying, the effect of eliminating fire and detoxication;
RADIX GLEHNIAE from Liaoning of China: return lung meridian; Stomach warp; Function: nourishing YIN and clearing away lung-heat; Reinforcing stomach reg fluid;
Radix Polygoni Multiflori: bitter, sweet, puckery, tepor, return liver, kidney channel, removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation, for scrofula carbuncle sore, suture needle pruritus, dryness of the intestine constipation, hyperlipemia;
Herba Ecliptae: liver and kidney tonifying; Cooling blood for hemostasis;
Semen Armeniacae Amarum: bitter, tepor, slightly poisonous.Return liver, large intestine channel; Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation;
Olibanum: enter the heart, liver, spleen channel, regulating qi and activating blood, analgesic therapy, chases after poison;
Testa sojae atricolor: dispelling wind nourishes blood;
The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, blood pressure lowering;
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence;
Stigma Maydis: expel the heat-evil treating stranguria, suppressing the hyperactive liver function of gallbladder promoting;
Radix Cirsii Japonici: cool in nature, sweet in the mouth, hardship, nontoxic; GUIXIN, Liver Channel; Control haematemesis, epistaxis, hematuria, stranguria with blood, metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, acute appendicitis, carbuncle and ulcer toxic swelling, furuncle;
Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature; Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria;
Cortex Lycii: heat clearing away, removing heat from blood;
Rhizoma Chuanxiong: pungent, warm, return liver, gallbladder, pericardium channel, blood-activating and qi-promoting, wind-expelling pain-stopping, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia;
Flos Rosae Rugosae: there is strong liver and nourishing stomach, promoting blood flow to regulate menstruation, loosening bowel to relieve constipation, the effect of resolving stagnation for tranquilization;
Radix Asparagi: sweet in the mouth; Bitter; Cold in nature; Nourshing Yin and drynsessmoistening prescription; Lung heat clearing is promoted the production of body fluid;
Sargassum: softening the hard mass; Expectorant; Diuretic; Detumescent;
Fructus Mume: sour, puckery, flat; Return liver, spleen, lung, large intestine channel; Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris; For chronic cough of deficiency lung; Deficiency-heat excessive thirst;
Rhizoma Atractylodis: cure mainly the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia;
Fructus Schisandrae Chinensis: astringing lung-QI and relieving cough; Hidroschesis promotes the production of body fluid;
Radix Stephaniae Tetrandrae: wind-damp dispelling, pain relieving, diuretic;
PINGDIMU: reduce phlegm, cough-relieving, dampness removing, invigorate blood circulation.
Cornu Cervi Degelatinatum: salty, temperature; Return liver, kidney channel; Warming the kidney to activate YANG, astringing to arrest bleeding; For spleen kidney yang flaccidity, lack of appetite and vomiting, leucorrhea, enuresis frequent micturition, metrostaxis, carbuncle sucutaneous nodule;
Radix Glycyrrhizae: sweet, flat, GUIXIN, lung, spleen, stomach warp, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, the cardiopalmus deficiency of vital energy, cough with copious phlegm, carbuncle sore tumefacting virus.
Applicant is in regulating lipid therapy, insufficiency of the spleen from etiology and pathogenesis, expectorant is turbid, blood stasis, uses the Therapeutic Principle of reinforcement and elimination in combination, regulates blood lipid metabolism, reduces Blood Lipids in Hyperlipemia Patients level, and improves patient's quality of life.Selected above each crude drug is through dialectical compatibility, synergism, and long memorial liver promoting flow of QI and blood, spleen reinforcing stomach reinforcing eliminate indigestion, clearing away heat and cooling blood dissipating blood stasis, the kidney invigorating effect of intestine moistening of promoting the production of body fluid, can reduce Blood Lipids in Hyperlipemia Patients level altogether, and hyperlipidemia patient is had to significant curative effect.
The specific embodiment
By following proportioning, take each crude drug:
Treat a Chinese medicine composition for hyperlipemia, it is to be made by the crude drug of following weight parts proportioning:
Herba Hedyotidis Diffusae 100g, Herba Orostachyos 60g, Semen Cassiae 40g, Fructus Kochiae 85g, Cacumen Platycladi 30g, Herba Medicaginis 20g, Fructus Forsythiae 125g, Rhizoma Coptidis 160g, RADIX GLEHNIAE from Liaoning of China 120g, Radix Polygoni Multiflori 150g, Herba Ecliptae 120g, Semen Armeniacae Amarum 105g, Olibanum 60g, Testa sojae atricolor 120g, Cortex Eucommiae 150g, Radix Paeoniae Rubra 150g, Stigma Maydis 60g, Radix Cirsii Japonici 100g, Rhizoma Alismatis 120g, Cortex Lycii 150g, Rhizoma Chuanxiong 100g, Flos Rosae Rugosae 120g, Radix Asparagi 70g, Sargassum 95g, Fructus Mume 45g, Rhizoma Atractylodis 80g, Fructus Schisandrae Chinensis 100g, Radix Stephaniae Tetrandrae 120g, PINGDIMU 150g, Cornu Cervi Degelatinatum 120g, Radix Glycyrrhizae 100g.
Preparation method is as follows:
Get Herba Hedyotidis Diffusae, Herba Orostachyos, Semen Cassiae, the Fructus Kochiae, Herba Ecliptae, Semen Armeniacae Amarum, Olibanum, Testa sojae atricolor, the Cortex Eucommiae, Radix Paeoniae Rubra, Stigma Maydis, Cornu Cervi Degelatinatum, Radix Glycyrrhizae, adding 6 times of weight decoctings boils twice, each 1.5 hours, filter, merging filtrate, be evaporated to relative density 1.10-1.15 (60 ℃), then add straight alcohol to make to reach 60% containing alcohol amount, standing over night, draw supernatant, be evaporated to the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure, gets dry extract one.
Get again residue 18 taste crude drug, add 8 times of weight decoctings and boil twice, each 1.5 hours, filter, merging filtrate, be evaporated to relative density 1.10-1.15 (60 ℃), adding that straight alcohol makes containing alcohol amount is that the mass percent of ethanol reaches 60%, standing over night, draw supernatant, be evaporated to the thick paste of relative density 1.30-1.35 (60 ℃), drying under reduced pressure, gets dry extract two.
Get above-mentioned dry cream one and dry cream two, pulverize respectively, mix, then add dextrin, dry cream one is 1: 3 with the gross weight of dry cream two and the ratio that dextrin adds weight, and mix homogeneously is granulated, dry, encapsulated, obtains.
Capsule specification is: 0.3-0.5g/ grain.
Prescription science of the present invention, compatibility is reasonable, there is the promote the production of body fluid effect of intestine moistening of soothing the liver promoting flow of QI and blood, spleen reinforcing stomach reinforcing eliminate indigestion, clearing away heat and cooling blood dissipating blood stasis, the kidney invigorating, pain in chest and hypochondrium, fatigue and weakness, abdominal distention food stagnation, bitter taste nausea, dryness of the intestine Tianjin that hyperlipidemia patient is occurred are withered, the symptoms such as thick fur is greasy, stringy and hesitant pulse have unique curative effect.
Below in conjunction with clinical data, illustrate beneficial effect of the present invention:
1. case selection standard
Inclusive criteria: (1) age was at the sex of 18～68 years old; (2) meet hyperlipemia diagnostic criteria, it drafts standard with reference to Chinese Medical Association's metabolic disease special interest group.1. hyperlipemia diagnostic criteria; 2. hyperlipemia clinical stages standard; 3. TCM syndrome diagosis is with reference to the standard of the guideline of clinical investigations > > of < < new Chinese medicine treatment hyperlipemia.
Exclusion standard: (1) is diagnosed as Primary hyperlipemia patient; (2) gestation or prepare gestation and age of sucking female; (3) merge intentionally, the serious disease such as brain, lung, kidney, hemopoietic system, or have the patient of the wasting diseasess such as active tuberculosis or renal transplantation the latter; (4) psychotic, can not partner.
2. physical data
Observation case is 2010 05 month and is in hospital and out-patient to 2013 First People's Hospital, economic and technological development zone, Nian05Yue Qingdao City, has complete medical history information, totally 120 examples.Adopt completely randomized design scheme, application table of random number method, the sequencing medical by patient is divided into treatment group 60 examples at random by it, man's 34 examples, female's 26 examples, 30～67 years old age, on average (50.4 ± 11.6) year old, matched group 60 examples, male 30 examples, female's 30 examples, 31～68 years old age, average (51.6 ± 12.8) year, each organizes TC, TG before patient's physical data and treatment, LDL-C and other laboratory Index for examinations of hyperlipemia through harmony comparison, difference there are no significant meaning (P ﹥ 0.05), has comparability.
3. Therapeutic Method
All patients all adopt nutrition dietary, according to the state of an illness, in conjunction with controlling blood pressure, blood glucose, regulate the anti symptom treatment such as electrolyte balance.On above-mentioned treatment basis, treatment group gives capsule for improving blood circulation and reducing fat of the present invention, and warm water takes, every day 3 times, each 2 (0.3 gram /).Matched group is treated with Atorvastatin calcium, 20mg, every day 1 time.It within 4 weeks, is a course for the treatment of.
4. therapeutic evaluation
With reference to new Chinese medicine in < < new Chinese medicine guideline of clinical investigations > >, treat hyperlipemia guideline of clinical investigations and draft efficacy assessment standard in conjunction with clinical experience.Clinical recovery: clinical symptoms, sign disappear or substantially disappear, main physical and chemical index is normal; Effective: clinical symptoms, sign are obviously improved, main physical and chemical index normal; Effective: clinical symptoms, sign all take a favorable turn, main physical and chemical index normal; Invalid: clinical symptoms, sign are all not improved, even increase the weight of.
5. result
Between two groups, general curative effect is compared as follows table 1.
Table 1
6. untoward reaction
After capsule for improving blood circulation and reducing fat treatment group of the present invention has some cases to take medicine in observation period, have the reactions such as slight stomach discomfort, times of defecation increase, suitably reduce dosage or take medicine after meal after mostly eliminate; Atorvastatin calcium matched group, occasionally has flatulence to occur, and after suitable oral digestive tract power reinforcing medicine, can correct.
In sum, above application medicine of the present invention is done treatment to 60 routine hyperlipidemia patients and is observed, and obtains significant curative effect, and before and after treatment, the heart, lung, renal function and defecation check, all do not find obvious toxic-side effects, drug administration safety of the present invention is described, to human body nonhazardous effect.
Claims (1)
1. a Chinese medicine composition for the treatment of hyperlipemia, it is characterized in that it is to be made by the crude drug of following weight parts proportioning: 100 parts of Herba Hedyotidis Diffusaes, 60 parts of Herba Orostachyos, 40 parts of Semen Cassiaes, 85 parts of the Fructus Kochiae, 30 parts of Cacumen Platycladis, 20 parts of Herba Medicaginiss, 125 parts of Fructus Forsythiaes, 160 parts of Rhizoma Coptidis, 120 parts of RADIX GLEHNIAE from Liaoning of China, 150 parts of Radix Polygoni Multifloris, 120 parts of Herba Ecliptaes, 105 parts of Semen Armeniacae Amarums, 60 parts of Olibanums, 120 parts of Testa sojae atricolors, 150 parts of the Cortexs Eucommiae, 150 parts of Radix Paeoniae Rubra, 60 parts of Stigma Maydis, 100 parts of Radix Cirsii Japonicis, 120 parts of Rhizoma Alismatis, 150 parts of Cortex Lycii, 100 parts of Rhizoma Chuanxiongs, 120 parts of Flos Rosae Rugosaes, 70 parts of Radix Asparagis, 95 parts of Sargassums, 45 parts of Fructus Mumes, 80 parts of Rhizoma Atractylodis, 100 parts of Fructus Schisandrae Chinensis, 120 parts of Radixs Stephaniae Tetrandrae, 150 parts of PINGDIMU, 120 parts of Cornu Cervi Degelatinatums, 100 parts, Radix Glycyrrhizae.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104758667A (en) * | 2015-03-17 | 2015-07-08 | 济南骄泰信息技术有限公司 | Blood-fat-reducing traditional Chinese medicine |
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| CN1413601A (en) * | 2001-10-22 | 2003-04-30 | 孟宪茹 | Chinese medicine for compound circulation treatment of angiocardiopathy and cerebrovascular disease |
| CN103656535A (en) * | 2013-12-30 | 2014-03-26 | 孙春红 | Chinese medicinal composition for treating hyperlipidemia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104758667A (en) * | 2015-03-17 | 2015-07-08 | 济南骄泰信息技术有限公司 | Blood-fat-reducing traditional Chinese medicine |
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Application publication date: 20140827 |