CN104984255A - Traditional Chinese medicine pill for auxiliary treatment on alcoholic fatty liver and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine pill for auxiliary treatment on alcoholic fatty liver and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The effective component of the pill is composed of the following raw materials: radix fici simplicissimae, ampelopsin grossedentata, curcuma tuber, poncirus trifoliate, leaf and stem of ficus erecta, sweet potato vine, radix scutellariae, fingered citron, wolfberry, semen cuscutae, wrinkled giant hyssop, licorice, loofah sponge, brassica chinensis, safflower, white peony root, pine pollen, flatstem milkvetch seed, oriental waterplantain rhizome, dried orange peel, corydalis adunca, tabasheer, American ginseng, and plum blossom. The provided traditional Chinese medicine pill has a definite curative effect, has the functions of nourishing liver and kidney, invigorating the spleen, resolving dampness, clearing heat, reducing phlegm, activating blood circulation, freeing the collaterals, soothing the liver, regulating qi, promoting digestion, relieving alcoholism, harmonizing the stomach, and stopping vomiting, has the advantages of good absorption effect, prominent curative effect, no side or toxic effect, and no adverse reaction in clinic, and has a high cure rate on treating alcoholic fatty liver in clinic.

Description

A kind of medicine pill for auxiliary treatment alcoholic fatty liver and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine pill for auxiliary treatment alcoholic fatty liver and preparation method.

Background technology

Alcoholic fatty liver is the hepatic disease because long-term heavy drinking causes, and is a typing in alcoholic liver disease.Patient has long-term alcohol history, generally more than 5 years.Clinical symptoms is non-specific, can be asymptomatic, or have upper right abdominal distention and pain, inappetence, weak, lose weight.Nearly ten years, along with the raising of living standards of the people and the expansion of social circle, the consumption figure of global wine surges, and meanwhile, the generation of alcoholic fatty liver also significantly increases.In China, cause the incidence rate of alcoholic fatty liver owing to drinking also in obvious ascendant trend, become the implicit type killer that can not be ignored.

Modern medicine study proves, ethanol has direct detrimental effect to liver, and its micromechanism of damage is that ethanol causes at hepatocyte intracellular metabolite.Enter hepatocellular ethanol, acetaldehyde is changed under the effect of ethanol dehydrogenase and microsomal ethanol oxidase system, change acetic acid into again, NADH (NADH) can suppress mitochondrion tricarboxylic acid cycle with the rising of reactive cozymase (NAD) ratio, make intrahepatic fat acid metabolic generation obstacle, oxidation reduction, makes neutral fat be piled up in hepatocyte.In addition, the synthesis increasing and promote fatty acid of NADH, thus make fat pile up in hepatocyte and steatosis occurs, finally cause alcoholic fatty liver to be formed.As the indexs such as serum glutamic pyruvic transminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) or γ-paddy ammonia transferring enzyme (GGT) slightly raise during clinical examination, the general Western medicine that need use carries out Drug therapy, as such as serum glutamic pyruvic transminase (ALT), glutamic oxaloacetic transaminase, GOT (AST) or γ-paddy ammonia transferring enzyme (GGT) slightly raises, can consider that drug application is treated.As the Western medicine such as tiopronin, polyene phosphatidylcholine; can available protecting hepatocyte, promote hepatocyte metabolic enzyme activity, improve blood lipid metabolism, improve liver function; improve clinical symptoms and the biochemical index of alcohol fatty hepatopath, reach healing object.But the western medicine treatment time of alcoholic fatty liver is longer, and Long-term taking medicine easily occurs toleration, and has certain side effect to patient body health.Improve the clinical symptoms of alcohol fatty hepatopath and biochemical index and can improve clinical symptoms and the biochemical index that the clinical symptoms of alcohol fatty hepatopath and biochemical index improve alcohol fatty hepatopath.

The traditional Chinese medical science thinks that primary disease belongs to the category such as " hypochondriac pain ", " gathering ", " feeling of fullness ".Its etiology and pathogenesis is because of excessive consumption of alcohol, and alcoholism is damp and hot accumulates long-pending middle Jiao, injures taste, involves liver and gall, dysfunction of the spleen in transportation, accumulatively wet raise phlegm, damp-heat accumulation, hinder and form under the side of body.Chinese medicine preparation conventional is at present primary treatment principle mainly with dispersing the stagnated liver-QI for regulating the stomach, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, invigorating the stomach and promoting digestion, as publication No. CN 103083573A (application number: Chinese patent literature 201310043267.4) discloses a kind of Chinese medicine for the treatment of alcoholic fatty liver, and this Chinese medicine composition is by Herba Swertiae Puniceae, Herba Meliloti Suaveolentis, Radix Oenotherae erythrosepalae, Fructus Akebiae, marigold flower, Stigma Maydis, Rhizoma Polygoni Cuspidati, Pericarpium Citri Reticulatae Viride, Cynara scolymus L (Cyhara cardunculus.), Herba Camptosori Sibirici, Endoconcha Sepiae is made.Pharmaceutical formulation of the present invention adjusts repeatedly through Long-term clinical checking, suit the remedy to the case according to the cause of disease, have containing some in side and relieve the effect of alcohol, protect the liver, the Chinese medicine of fat-reducing effect, as Fructus Tsaoko selected in side, Pericarpium Citri Reticulatae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), the Chinese medicines such as Pollen Pini have effect of alcoholic intoxication, Radix Panacis Quinquefolii selected in side, Plantula Brassicae chinensis, Radix Glycyrrhizae, Fructus Lycii, Rhizoma Alismatis, the Chinese medicines such as Pericarpium Citri Reticulatae confirm to have effect for reducing blood fat through modern medicine study, Radix Scutellariae in side, Semen Cuscutae, the Chinese medicines such as the Radix Paeoniae Alba have and protect the liver, effect of function of gallbladder promoting, in side, all medicines share and have nourishing the liver nourishing kidney, invigorating the spleen for eliminating dampness, removing heat-phlegm, promoting blood circulation to remove obstruction in the collateral, depressed liver-energy dispersing and QI regulating, help digestion and relieve the effect of alcohol, effect of stomach function regulating preventing or arresting vomiting, fat can be eliminated fast, allaying tiredness, reduce blood fat, improve liver function, reach healing object, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to alcoholic fatty liver cure rate through clinical verification.

Summary of the invention

The invention provides a kind of medicine pill for auxiliary treatment alcoholic fatty liver and preparation method, there is nourishing the liver nourishing kidney, invigorating the spleen for eliminating dampness, removing heat-phlegm, promoting blood circulation to remove obstruction in the collateral, depressed liver-energy dispersing and QI regulating, help digestion relieve the effect of alcohol, effect of stomach function regulating preventing or arresting vomiting, cure the disease and ask source treating both the principal and secondary aspects of a disease, to alcoholic fatty liver, there is good curative effect.

For achieving the above object, technical scheme of the present invention is implemented as follows:

For medicine pill and the preparation method of auxiliary treatment alcoholic fatty liver, raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

Raw material composition and the parts by weight of making described effective ingredient are:

For a preparation method for the medicine pill of auxiliary treatment alcoholic fatty liver, comprise the following steps:

(1) Herba Fici Simplicissimae, Ampelopsis grossedentata, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Caulis et Folium Fici beecheyanae, Caulis et Folium fici Tikouae, Fructus Citri Sarcodactylis, Fructus Lycii, Semen Cuscutae, Herba Pogostemonis, Retinervus Luffae Fructus, Plantula Brassicae chinensis, Flos Carthami, Pollen Pini, Semen Astragali Complanati, Pericarpium Citri Reticulatae, Dendrobium denneanum Kerr. flower, Concretio silicea Bambusae seu schizostachyi, Radix Panacis Quinquefolii, Flos Mume are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) get Radix Curcumae sheet to mix thoroughly with rice vinegar, vexed, put the interior slow fire of pot and heat fried dry, taking-up cools, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(3) get scutellaria tablet and a certain amount of yellow wine is mixed thoroughly, slightly moistening, after yellow wine is sucked, put in parch container, use slow fire fried dry, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(4) get clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, put in parch container, slow fire is fried to yellow to buff, and take out time tack-free, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(5) be spread on by wheat bran in hot pot, pour Radix Paeoniae Alba sheet in time smoldering into, fry to micro-yellow, take out spreading for cooling, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) get Rhizoma Alismatis sheet, spray and mix thoroughly, slightly moistening with saline, put the micro-stir-fry of the interior slow fire of pot to surface and omit now yellow taking-up, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1) gained, mix with the fine powder of gained in step (2), step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of every 3g.

The property of medicine of the present invention's Chinese medicine used is as follows:

Herba Fici Simplicissimae: sweet in the mouth; Property is put down.Invigorating the spleen for eliminating dampness, promoting the circulation of QI and reducing phlegm, relaxing muscles and tendons and activating QI and blood in the collateral.Cure mainly insufficiency of the spleen edema; Lack of appetite is unable; Pulmonary tuberculosis cough; Night sweat; Leukorrhagia; Puerperal agalactia; Rheumatic arthralgia; Edema; Cirrhotic ascites; Hepatitis; Traumatic injury.Modern medicine study proves: psoralen is one of main active of Herba Fici Simplicissimae, has the effect such as antibacterial, antiviral, anticoagulation, Tumor suppression, immunomodulating.

Ampelopsis grossedentata: bitter in the mouth; Micro-puckery; Cool in nature.Clearing away heat-damp and promoting diuresis; Suppressing the hyperactive liver blood pressure lowering; Promoting blood circulation to remove obstruction in the collateral.Cure mainly dysentery; Have loose bowels; Urine leaching pain; Hypertension; Dizzy order is swollen; Traumatic injury.

Radix Curcumae: acrid in the mouth; Bitter; Cold in nature.Enter the heart; Liver; Gallbladder meridian.To invigorate blood circulation relieving convulsion; Promoting QI circulation for relieving depression; Clear away heart-fire removing heat from blood; Depressed liver-energy dispersing and function of gallbladder promoting.Cure mainly all pains of breast abdomen side of body rib; Dysmenorrhes; Amenorrhea; WEIJIA is lumpd; Calentura coma; Demented; Infantile convulsion; Spit blood; Epistaxis; Stranguria with blood; Sand Stranguria; Jaundice.Essentials of Matea Medica carries: " circulation of qi promoting, resolving depression; Let out blood, removing blood stasis with potent drugs.Cool heat in the heart, loose stagnation of liver-QI, can open the strongly fragrant of lung gold." modern medicine study confirmation, Radix Curcumae is rich in Radix Curcumae polysaccharide, and have and strengthen reticuloendothelial system activity, ethanol extract, on the original obvious impact of fibrin, can reduce T-CHOL and content of triglyceride in aorta.

Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus): acrid in the mouth; Bitter; Warm in nature.Return liver; Stomach warp.Dispersing the stagnated liver-QI for regulating the stomach; Regulating QI to relieve pain; Removing food stagnancyization is stagnant.Cure mainly fullness and distention in the chest and hypochondrium; Abdominal distention; Breast lumps; Hernia pain; Painful and swollen testis; Traumatic injury; Food stagnation; Constipation; Uterine prolapse." herbal classic is met former ": dispelling the stagnated QI dispels the heat, alcoholic intoxication.

Caulis et Folium Fici beecheyanae: sweet in the mouth; Light; Warm in nature.Return lung; Spleen; Kidney channel.Invigorating middle warmer spleen invigorating; Wind-damp dispelling; Promoting blood circulation to remove obstruction in the collateral.Cure mainly the deficiency of vital energy weak; Extremity are aching and limp; Rheumatic arthralgia; Stiffness of the muscle and joint; Traumatic injury; Amenorrhea; Galactostasis.

Caulis et Folium fici Tikouae: bitter in the mouth; Cold in nature.Clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral; Removing toxic substances and promoting subsidence of swelling.Cure mainly cough due to lung-heat; Dysentery; Edema; Yellow cellulitis; Infantile dyspepsia; Rheumatalgia; Amenorrhea; Leukorrhagia; Traumatic injury; Bleeding hemorrhoids; Innominate toxic swelling." Guangxi Chinese herbal medicine ": invigorating spleen to remove dampness, clearing away lung-heat to relieve cough.Control infantile dyspepsia, jaundice due to damp-heat, cough due to pathogenic wind-heat, rheumatic ostalgia.

Radix Scutellariae: bitter in the mouth; Cold in nature.Return lung; Gallbladder; Spleen; Stomach; Large intestine; Small intestine meridian.Heat clearing and damp drying; Eliminating fire and detoxication; Arresting bleeding and miscarriage prevention; Blood pressure lowering.Cure mainly hygropyrexia, heat-damp in summer vomiting and nausea uncomfortable in chest; Damp and hot feeling of fullness; Dysentery; Jaundice; Cough due to lung-heat; Heat in blood tells nosebleed; Carbuncle sore tumefacting virus; Frequent fetal movement." herbal classic " carries: " main all hot jaundice, intestinal is out-of-the-way, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, malignant boil, and cellulitis is lost, acute scleritis." modern medicine study confirms, Radix Scutellariae has the effect such as antibacterial, antifungal, antiviral, antiinflammatory, antiallergic action significantly, can reduce blood pressure, anticoagulant, anticoagulant, blood fat reducing, to protect the liver in addition in addition, function of gallbladder promoting, antioxidation, anticancer function.

Fructus Citri Sarcodactylis: acrid in the mouth; Bitter; Warm in nature.Enter liver; Stomach; Spleen; Lung meridian.Liver-smoothing, qi-regulating; Stomach function regulating reduces phlegm.Cure mainly the hypochondriac pain of depression of liver-QI; Breast is vexed; Incoordination between the liver and stomach; The abdominal distention of stagnation of QI in spleen and stomach; Yuan gas; Feel sick; Chronic cough abundant expectoration." book on Chinese herbal medicine is new again " carries: " control gas soothing liver-QI, stomach function regulating reduces phlegm, and removing mass controls dysphagia and regurgitation, eliminating mass abdominal mass scrofula." modern medicine study confirmation; Fructus Citri Sarcodactylis has phlegm-dispelling functions of relievining asthma; antagonism airway constriction; the tension force alleviating rapidly stomach, intestinal and gallbladder increases; extend convulsions time of origin, prevention arrhythmia, the resistance of increase strong wool blood vessel; reduce the ascorbic discharge of adrenal gland, also have the effect of antiinflammatory, antimicrobial acivity in addition.

Fructus Lycii: sweet in the mouth; Property is put down.Return liver; Kidney; Lung meridian.Nourishing the liver; Nourishing kidney; Lung moistening.Cure mainly caused by liver and kidney deficiency; Have a dizzy spell; Visual one clear; Soreness of the waist and knees; The expensive essence of sexual impotence; Cough due to consumptive disease; To quench one's thirst taking fluids profusely." book on Chinese herbal medicine just " carries: " improve visual and auditory acuity, adds the solid marrow of essence, strengthen the muscle and bone, and kind benefit impairment caused by overstrain, especially only quenches one's thirst." modern medicine study confirm, Fructus Lycii scalable body's immunity, can effectively Tumor suppression grow and cell mutation, there is the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function.

Semen Cuscutae: acrid in the mouth; Sweet; Property is put down.Enter liver; Kidney; Spleen channel.The kidney invigorating and essence nourishing; Nourishing the liver to improve visual acuity; Gu tire stopping leak.Cure mainly soreness of waist and knee joint; Seminal emission; Sexual impotence; Premature ejaculation; Sterile; Quench one's thirst; Stranguria with turbid discharge; The enuresis; Blurred vision tinnitus; Frequent fetal movement; Miscarriage; Have loose bowels." book on Chinese herbal medicine converge with speech " carries: " the kidney invigorating nourishing the liver, warming the spleen helps the medicine of stomach also, but mends and not high, temperature and not dry, and void can be mended, in fact can be in order to, cold can temperature, heat can be cool, and temperature can be dry, dryly can moisten." modern medicine study confirms, Semen Cuscutae can protect hepatic injury active significantly, increases nonspecific resistance, enhancement vigor, also has antitumor, antiinflammatory, antisterility, diarrhea inducing in addition and suppresses the effect of central nervous system.

Herba Pogostemonis: acrid in the mouth; Slightly warm in nature.Return spleen; Stomach; Lung meridian.Removing dampness by means of aromatics; Stomach function regulating preventing or arresting vomiting; Dispelling summer-heat from superficies of the body.Cure mainly gastral cavity abdomen painful abdominal mass Min of retention of dampness in middle-JIAO; Inappetence; Vomiting; Have loose bowels; The cold and heat headache of diseases caused by exogenous pathogenic factor heat-damp in summer; Hygropyrexia from the beginning of heating body be stranded; Feel sick in breast Min; Nasal sinusitis; Tinea manus and pedis." book on Chinese herbal medicine is new again ": " inducing diaphoresis to expel pathogens, dampness removing, except wind, relieves heat and thirst.Stopping vomiting tells cholera, malaria, dysentery, skin ulcer scabies.Stalk: can sore throat be controlled, reduce phlegm, cough-relieving coughs."

Radix Glycyrrhizae: sweet in the mouth; Property is put down.GUIXIN; Lung; Spleen; Stomach warp.Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity.Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, draft is malicious by every means to separate 1,002, is in harmonious proportion from medicine and gains merit." modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; be widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, have anti-gastric-ulcer, gastritis effect in addition.

Retinervus Luffae Fructus: bitter in the mouth; Cool in nature.Return lung; Liver; Stomach warp.Dredge the meridian passage, removing heat-phlegm.Cure mainly: pain in chest and hypochondrium; Rheumatic arthralgia, passages through which vital energy circulates contracture, galactostasis, lung gesture is coughed, carbuncle future sore, his carbuncle." book on Chinese herbal medicine is new again ": " the meridian dredging, and blood vessels reduce phlegm pleasant." modern medicine study proves: Retinervus Luffae Fructus is containing xylan, mannan, galactan etc.Decoct, fresh juice and methanolic extract have antitussive action; Methanolic extract is significantly increased the phenol red effect of respiratory tract excretion; Decoct and ethanol preserved material have inhibitory action to streptococcus pneumoniae and respiratory tract common bacteria.

Plantula Brassicae chinensis: sweet in the mouth; Property is put down.Return lung; Stomach warp.Removing heat from the lung and dissipating phlegm; Help digestion relieving alcoholic intoxication.Cure mainly phlegm-heat cough; Food stagnation; Drunk.Modern scientific research proves: its seed oil can reduce the hypercholesterolemia in rat serum and liver, and this oil promotes lipid transfer and causes cholesterol to decline in rat serum and tissue.

Flos Carthami: acrid in the mouth; Warm in nature.Enter liver; Kidney channel.Promoting blood circulation to restore menstrual flow, scattered silt pain relieving.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." Guizhou medical herbs " carries: " heat-clearing and toxic substances removing, controls innominate toxic swelling, fracture." modern medicine study confirmation, Flos Carthami is improved human body immune function, blood pressure lowering, blood fat reducing, increase coronary flow and the multiple pharmacological effect such as myocardial alimentary blood flow, inhibition thrombosis.

The Radix Paeoniae Alba: bitter in the mouth; Property is put down.Enter liver; Spleen channel.Nourishing blood to suppress the hyperactive liver, pain relieving in slow; Yin fluid astringing receives antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency." not Lu " carries: " clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when controlling, and attacked by pestiferous factors is suffered from abdominal pain, lumbago." modern medicine study confirms; Radix Paeoniae Alba energy immunity moderation; strengthen macrophage and leukocytic phagocytic function; regulate the immunologic function of T lymphocyte and body fluid; protect the liver, spasmolytic, analgesia, calmness, anti-cool, cooling effect; have inhibitory action to smooth muscle in addition, strengthen the effect of anoxia enduring, antioxidation and resisting fatigue.

Pollen Pini: sweet in the mouth, warm in nature.Enter liver channel of foot-Jueyin, spleen meridian.To dispel the wind QI invigorating, removing dampness, hemostasis.Controlling head revolves dizzy, and middle void has a stomach-ache, chronic dysentery, and all skin ulcers wet rotten, wound hemorrhage." book on Chinese herbal medicine converges and says ": " treat chronic dysentery, alcoholic intoxication, clearing away heat from blood."

Semen Astragali Complanati: warm in nature, sweet in the mouth.Return Liver Channel, kidney channel.Temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.With controlling lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.Modern study proves: Semen Astragali Complanati is containing triterpene glucosides, flavone and multiple glucosides, isoflavone aglycone, aminoacid and multiple fatty acid compound and Macro and microelements.There is adaptation former state, shrink uterus and reducing urination, blood pressure lowering, antiinflammatory, protect the liver, improve the effect such as hemorheological property and anticoagulant, increase cerebral blood flow, Adjust-blood lipid.

Rhizoma Alismatis: sweet in the mouth; Light; Cold in nature.Return kidney; Urinary bladder channel.Promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Cure mainly dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission." not Lu " carries: " tonifying deficiency five kinds of over strain, except the five internal organs feeling of fullness, plays cloudy gas, stopping leak essence, quenches one's thirst, drenches drop, cuts off the water by bladder, three Jiao." modern medicine study confirmation, Rhizoma Alismatis has reduction cholesterol and atherosclerosis effect, improves liver lipid metabolism, reduces blood glucose, blood pressure, affects function of immune system, reduces serum hemolysin.

Pericarpium Citri Reticulatae: acrid in the mouth; Sweet; Cold in nature.Enter spleen; Stomach warp.The therapeutic method to keep the adverse QI flowing downwards; In tune; Reduce phlegm; Relieving alcoholic intoxication.Cure mainly drinking and eating irregularly; Upper gas stuffy sensation with restlessness; Get sick from drinking too much wine thirsty." Japan hanako materia medica " carries: " skin is processed and is made soup, can alcoholic intoxication and wine thirsty, typhoid fever diet recurrence caused by overexertion person, densely decocts juice clothes." medicine clinical research shows; the Hesperidin contained by Pericarpium Citri Reticulatae can suppress gastric ulcer; reduce capillary permeability; have adjustment gastrointestinal function and antiinflammatory action; its volatile oil has eliminating the phlegm, relievings asthma, facilitating digestion liquid secretion and get rid of the effects such as enteral pneumatosis, also has coronary artery dilator in addition, reduces blood pressure and the effect such as function of gallbladder promoting.

Dendrobium denneanum Kerr. flower: bitter in the mouth; Cool in nature.Return lung; Liver; Gallbladder meridian.Clearing away lung-heat to relieve cough; Liver heat removing function of gallbladder promoting; Pain relieving.Cure mainly cough due to lung-heat; Heating chest pain; Dampness-heat in the liver and gallbladder; Hypochondriac pain; Heating; Anorexia is greasy; Jaundice; Diarrhea due to damp-heat.

Concretio silicea Bambusae seu schizostachyi: sweet in the mouth; Cold in nature.GUIXIN; Liver; Gallbladder meridian.Removing heat-phlegm; Cool heart arresting convulsion.Cure mainly infantile convulsion; Epilepsy; Middle wind-phlegm fan; Calentura coma; Expectorant heat syndrome cough is breathed heavily." Shi Jinmo is to medicine ": " removing damp-heat preventing phlegm from forming and stopping coughing, the most suitable children's's expectorant heat is handed over vehement, dyspepsia, or wind-phlegm will be done, and order eyeball is dull for Concretio Silicea Bambusae, Pinellia leaven, two medicine 5 use.”

Radix Panacis Quinquefolii: sweet in the mouth; Micro-hardship; Cold in nature.Return lung; Stomach; The heart; Kidney channel.Boosting qi and nourishing yin; Relieve inflammation or internal heat and promote the production of body fluid.Cure mainly: the cloudy specially hyperactivity of fire of the deficiency of vital energy, cough expectorant blood, deficiency-heat is tired tired, and interior-heat is quenched one's thirst, and dry mouth cigarette is done." book on Chinese herbal medicine asks former ": lung heat clearing kidney, cool heart spleen, with pathogenic fire reducing, is relieved summer heat, is relieved the effect of alcohol.Modern study proves: the Saponin in Radix Panacis Quinquefolii effectively can strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing; Radix Panacis Quinquefolii can arrhythmia, resist myocardial ischemia, anti-cardiac muscle oxidation, strengthening cardiac contractility ability; Radix Panacis Quinquefolii can improve immunity of organisms, reduces blood coagulability, suppresses platelet aggregation, atherosclerosis promote Growth of red blood cells, increase hematochrome; Radix Panacis Quinquefolii can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, has certain assosting effect to treatment diabetes.

Flos Mume: bitter in the mouth; Micro-sweet; Micro-acid; Cool in nature.Return liver; Stomach; Lung meridian.Dispersing the stagnated live-QI to relieve the stagnation of QI; Appetizing is promoted the production of body fluid; Reduce phlegm.Cure mainly gloomy vexed; Stomachache due to hyperactive liver-QI attacking the stomach; Globus hystericus; Scrofula sore.Supplementary Amplifications of the Compendium of Materia Medica carries: " powder for improving appetite is evil, and food of cooking congee, help the gas of sun clearly to rise, distillation point tea, promoting the production of body fluid to quench thirst, expelling summer-heat is washed tired." modern medicine study confirmation, the diseases such as Flos Mume contains the multiple volatile oil such as benzaldehyde, isoeugenol, benzoic acid, can be used for clinically treating incoordination between the liver and stomach, gastral cavilty distending pain over the hypochondrium, and Yuan gas is easypro.

The present invention compared with prior art, has following beneficial effect:

The present invention selects medical material, the property of medicine is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease, have nourishing the liver nourishing kidney, invigorating the spleen for eliminating dampness, removing heat-phlegm, promoting blood circulation to remove obstruction in the collateral, depressed liver-energy dispersing and QI regulating, help digestion relieve the effect of alcohol, effect of stomach function regulating preventing or arresting vomiting, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to alcoholic fatty liver cure rate through clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and weight are:

The processing step of process for preparing medicine of the present invention is:

(1) Herba Fici Simplicissimae, Ampelopsis grossedentata, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Caulis et Folium Fici beecheyanae, Caulis et Folium fici Tikouae, Fructus Citri Sarcodactylis, Fructus Lycii, Semen Cuscutae, Herba Pogostemonis, Retinervus Luffae Fructus, Plantula Brassicae chinensis, Flos Carthami, Pollen Pini, Semen Astragali Complanati, Pericarpium Citri Reticulatae, Dendrobium denneanum Kerr. flower, Concretio silicea Bambusae seu schizostachyi, Radix Panacis Quinquefolii, Flos Mume are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) get Radix Curcumae sheet to mix thoroughly with rice vinegar, vexed, put the interior slow fire of pot and heat fried dry, taking-up cools, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(3) get scutellaria tablet and a certain amount of yellow wine is mixed thoroughly, slightly moistening, after yellow wine is sucked, put in parch container, use slow fire fried dry, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(4) get clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, put in parch container, slow fire is fried to yellow to buff, and take out time tack-free, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(5) be spread on by wheat bran in hot pot, pour Radix Paeoniae Alba sheet in time smoldering into, fry to micro-yellow, take out spreading for cooling, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) get Rhizoma Alismatis sheet, spray and mix thoroughly, slightly moistening with saline, put the micro-stir-fry of the interior slow fire of pot to surface and omit now yellow taking-up, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1) gained, mix with the fine powder of gained in step (2), step (3), step (4), step (5), step (6), add after refined honey stirs, be prepared as the pill of every 3g.

Usage and dosage: oral, each 2 of every day 3 times, one hour ante cibum, with warm water delivery service, 30 days was 1 course for the treatment of.

Embodiment 2

The raw material composition of effective ingredient of the present invention and weight are:

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 3

The raw material composition of effective ingredient of the present invention and weight are:

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Embodiment 4

The raw material composition of effective ingredient of the present invention and weight are:

The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.

Clinical data:

1, case selection

The routine clinical observation of alcohol fatty hepatopath 80 selecting my institute to make a definite diagnosis, patient is divided into two groups at random.Treatment group 40 example, wherein male 33 example, women 7 example, 27 ~ 56 years old age, 38.6 years old mean age.Matched group 40 example, wherein male 34 example, women 6 example, 29 ~ 57 years old age, 39.4 years old mean age.Two groups of qualifications and record of service such as Gender, age are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, each 2 of every day 3 times, and one hour ante cibum, with warm water delivery service, 30 days was 1 course for the treatment of, took 2 courses for the treatment of.Matched group, according to the patient's condition of the alcoholic fatty liver diagnosed out, gives tiopronin injection 0.3g and adds in 0.9% normal saline 250ml, intravenous drip; Every day 1 time, be used in conjunction 4 weeks; Oral tiopronin tablet is changed into, every day 3 times, each 2 after 4 weeks.

Treatment before and terminate the course for the treatment of rear empty stomach blood sampling carry out liver function, blood fat and ultrasound diagnosis.

3, observation index and method:

Observe the change of clinical symptoms before and after treatment.

Routine examination liver function (ALT, AST), blood fat (TC, TG), B ultrasonic before two groups of treatments, as basic data before medication, treat the above-mentioned indices of repetition measurement after 8 weeks and compare.

4, efficacy determination:

Draft with reference to " new Chinese medicine guideline of clinical investigations " standard.

(1) cure: triglyceride (TG), T-CHOL (TC) and liver function test result are normal, liver ultrasound diagnosis recovers normal, and symptom disappears substantially;

(2) take a turn for the better: triglyceride (TG), T-CHOL (TC) and liver function test result are obviously improved, and liver ultrasound diagnosis is clearly better, and clinical symptoms obviously alleviates;

(3) invalid: every Index for examination and clinical symptoms are with treating front no significant difference.

5, result

Before and after table 1 liang group treatment, liver function and Blood Lipid compare (x ± s, n=40)

Treat front two groups of liver functions and blood fat compares, no significant difference (P>0.05); After treatment, two groups of liver functions and blood fat all obviously improve, and have statistical significance (P<0.01) with self more equal difference before treatment; The effect that the rear treatment group for the treatment of improves liver function and blood fat is all obviously better than matched group (P<0.05).

Table 2 liang group Clinical efficacy comparison

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

6, model case citing:

1, neat ××, man, 45 years old, workman.This patient drinks more than 20 year, each 200 ~ 400ml, upper right abdomen and umbilicus all pain is had time recent, health is weak, inappetence, find time medical: glutamate pyruvate transaminase (ALT): 89.4U/L, glutamic oxaloacetic transaminase, GOT (AST): 76.8U/L, blood fat: T-CHOL TC:5.69mmol/L, triglyceride TG:3.37mmol/L, ultrasound diagnosis is diagnosed as: alcoholic fatty liver, after taking 1 course for the treatment of of medicine of the present invention, clinical symptoms disappears completely, liver function (ALT, AST), blood fat (TC, etc. TG) index reaches arm's length standard, liver ultrasound diagnosis recovers normal, fully recover.

2, grandson's ××, female, 38 years old, business personnel.Patient work needs often to drink, its body obesity, malaise fatiguability, inappetence, abdominal part distension, occasionally there is nausea and vomiting sense, find time medical: glutamate pyruvate transaminase (ALT): 76.4U/L, glutamic oxaloacetic transaminase, GOT (AST): 59.7U/L, blood fat: T-CHOL TC:5.64mmol/L, triglyceride TG:2.87mmol/L, ultrasound diagnosis is diagnosed as: alcoholic fatty liver, after taking 2 courses for the treatment of of medicine of the present invention, clinical symptoms disappears completely, liver function (ALT, AST), blood fat (TC, etc. TG) index reaches arm's length standard, liver ultrasound diagnosis recovers normal, fully recover.

In sum, the clinical manifestation of alcoholic fatty liver is directly proportional to the degree of fatty infiltration of liver, in liver excess fat be removed after symptom can disappear, the property of medicine of medical material selected by medicine of the present invention is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease, the Chinese medicine such as Fructus Tsaoko, Pericarpium Citri Reticulatae, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Pollen Pini selected in side has effect of alcoholic intoxication; The Chinese medicine such as Radix Panacis Quinquefolii, Plantula Brassicae chinensis, Radix Glycyrrhizae, Fructus Lycii, Rhizoma Alismatis, Pericarpium Citri Reticulatae selected in side confirms to have effect for reducing blood fat through modern medicine study; In side the Chinese medicine such as Radix Scutellariae, Semen Cuscutae, Radix Paeoniae Alba have protect the liver, effect of function of gallbladder promoting; Wherein Pericarpium Citri Reticulatae has very strong antioxidant activity and reduces the effect of cholesterol, triglyceride; There is the composition of multiple blood fat reducing pharmacologically active in Rhizoma Alismatis, affect cholesterol absorption, stop cholesterol to deposit at liver; In side, all medicines share, there is nourishing the liver nourishing kidney, invigorating the spleen for eliminating dampness, removing heat-phlegm, promoting blood circulation to remove obstruction in the collateral, depressed liver-energy dispersing and QI regulating, help digestion relieve the effect of alcohol, effect of stomach function regulating preventing or arresting vomiting, fat can be eliminated fast, allaying tiredness, reduce blood fat, improve liver function, reach healing object, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to alcoholic fatty liver cure rate through clinical verification.

Claims (5)

1. for a medicine pill for auxiliary treatment alcoholic fatty liver, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

2. a kind of medicine pill for auxiliary treatment alcoholic fatty liver according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

3. a kind of medicine pill for auxiliary treatment alcoholic fatty liver according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

4. a kind of medicine pill for auxiliary treatment alcoholic fatty liver according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:

5. for a preparation method for the medicine pill of auxiliary treatment alcoholic fatty liver, it is characterized in that: comprise following processing step:

(1) Herba Fici Simplicissimae, Ampelopsis grossedentata, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Caulis et Folium Fici beecheyanae, Caulis et Folium fici Tikouae, Fructus Citri Sarcodactylis, Fructus Lycii, Semen Cuscutae, Herba Pogostemonis, Retinervus Luffae Fructus, Plantula Brassicae chinensis, Flos Carthami, Pollen Pini, Semen Astragali Complanati, Pericarpium Citri Reticulatae, Dendrobium denneanum Kerr. flower, Concretio silicea Bambusae seu schizostachyi, Radix Panacis Quinquefolii, Flos Mume are cleaned, dry rear mix homogeneously, put into container, add the water of 6 ~ 8 times amount in a reservoir, heated and boiled 2 ~ 3 hours, gets immersion after cooling; The water of 4 ~ 6 times amount is added again, heated and boiled 1 ~ 2 hour, immersion after cooling in remaining medicinal residues; Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15 ~ 1.25, for subsequent use;

(2) get Radix Curcumae sheet to mix thoroughly with rice vinegar, vexed, put the interior slow fire of pot and heat fried dry, taking-up cools, and sieve removes chip, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(3) get scutellaria tablet and a certain amount of yellow wine is mixed thoroughly, slightly moistening, after yellow wine is sucked, put in parch container, use slow fire fried dry, taking-up cools, and pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(4) get clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, put in parch container, slow fire is fried to yellow to buff, and take out time tack-free, cool, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(5) be spread on by wheat bran in hot pot, pour Radix Paeoniae Alba sheet in time smoldering into, fry to micro-yellow, take out spreading for cooling, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(6) get Rhizoma Alismatis sheet, spray and mix thoroughly, slightly moistening with saline, put the micro-stir-fry of the interior slow fire of pot to surface and omit now yellow taking-up, dry, pulverizing is ground into powder, crosses 120 order dusting covers, obtains fine powder, for subsequent use;

(7) by the thick paste of step (1) gained, with step (2), step (3), step (4), step (5), the fine powder of gained mixes in step (6), add after refined honey stirs, be prepared as the pill of every 3g.