KR20090094616A - Compositions for preventing or treating bacterial enteritis or Coccidiosis - Google Patents

Abstract

A composition for preventing or treating bacterial enteritis or coccidiosis, which contains natural oriental medicinal herb is provided to prevent risk of cross-tolerance of cattle pathogen and human pathogen. A composition for preventing and treating bacterial enteritis or coccidiosis comprises oriental medicinal herb containing Curcumae Rhizoma, Coptidis Rhizoma, Scutellariae Radix, Phellodendri Cortex, Gardeniae Fructus, Paeoniae Radix, Rhei Rhizoma and Terminaliae fructus. The oriental medicinal herb is extracted using water, ethanol, or its mixture solvent. The composition has the effects of promoting the growth of cattle and poultry. The composition is used in the form of powder, granule or tablet.

Description

Compositions for preventing or treating bacterial enteritis or Coccidiosis

The present invention relates to a composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, and more specifically, to the bacterial enteritis or coccidiosis of livestock and poultry containing natural herbal medicines, not conventional antibiotics or antiprotozoal agents as an active ingredient. It relates to a prophylactic or therapeutic composition.

Livestock and poultry mortality rates are high due to bacterial enteritis and coccidiosis in animals. Bacterial enteritis refers to a disease in which the intestinal mucosa is damaged by bacterial infection. Bacterial enteritis commonly found in livestock includes salmonellosis, proliferative ileitis, colitis, and donpyri. Coccidiosis is a parasitic disease caused by the Eimeria genus, which is a spores predominantly in poultry, including cattle and pigs, such as cattle and pigs. It is one of the major poultry diseases that poultry suffer from many difficulties because it leads to the estimated economic loss.

In order to reduce mortality caused by bacterial enteritis and coccidiosis, antibiotics and antiprotozoal agents are added to most feeds when raising livestock or poultry. The functions of these antibiotics can be broadly divided into promoting growth, preventing disease, and improving feed utilization. However, antibiotics used indiscriminately during livestock raising have problems such as the emergence of resistant bacteria to antibiotics, the ingestion of human antibiotics through meat, and environmental pollution.

Bacterial enteritis and coccidiosis of livestock are known to increase with respect to population breeding and dense breeding, and it is known that the use of antibiotics as additives in feeds not only reduces the disease but also promotes growth. Thus, in the livestock industry, antibiotics have been added to feeds to promote livestock growth and disease prevention, and antibiotics are abused and misused. Antibiotics or antiprotozoal agents accumulated in animals due to misuse of these antibiotics are a serious problem for humans to take antibiotics or antiprotozoal agents through meat, causing problems such as the development of resistant bacteria of antibiotics or antiprotozoal agents. . In addition, expensive antibiotics put economic burdens on livestock farmers.

In this regard, interest in organic livestock using natural antibiotics is increasing as one of the methods of livestock farming that can improve the problems of conventional livestock farming methods to promote the safety of livestock products, the economics of livestock farming, and livestock growth. However, this trend is a global trend and a timely request.

Since organic livestock can produce livestock of better quality than conventional livestock and are environmentally friendly, developing feed additives containing good natural antibiotics greatly promotes increased productivity.

Herbal extracts, probiotics, enzymes, etc. may be used as natural antibiotics, but the level of antibiotic replacement effect of natural antibiotics is important. The antimicrobial or antigenicity of the natural material itself has a disadvantage that is somewhat inferior to the effects of conventional organic compounds. Therefore, it is necessary to develop inexpensive natural antibiotics for the practical use of natural antibiotics, and to develop a combination of complex natural antibiotics whose synergistic antimicrobial or antigenicity is increased.

Natural herbal medicines that are known to have antimicrobial activity in the prior art include yellow lotus, yellow white, golden, gardenia and the like.

Colidis (Coptidis Rhizoma) is a rhizome that almost eliminates the roots of Colidis (Coptis japonica Makino) or other similar plants. It contains 7-9% berberine as the main active ingredient, and contains a small amount of coptisine, urbenine, qorenine, palmitine and the like. Berberine contained in rhubarb is known to inhibit carbohydrate metabolism of microorganisms, inhibit bacterial protein synthesis, form complex salts with nucleic acids, and inhibit bacterial growth. According to the study, berberine could be used as an alternative to chloramphenicol in the treatment of cholera. It is also known to have antiviral and antiprotozoal effects and to activate macrophages to enhance immunity (Huang K.C., The pharmacology of Chinese herbs, CRC Press. Inc., p 287, 1993).

Phellodendri Cortex is a stem bark peeled from the bark of Phellodendron amurense Ruprecht or other similar plants. The sulfur white contains various kinds of alkaloids, and is contained in the content of 0.6 to 2.5% with berberine as the main ingredient, palmatine, phellodendrine and the like. It is known that sulfur white has an antimicrobial effect, like Staphylococcus aureus, and is effective in Staphylococcus aureus, Cyclobacterium, Cholera and Gonococcus. In addition, baekbaek promotes the phagocytosis of leukocytes, expands blood vessels, increases coronary blood flow and lowers blood pressure (Huang KC, The pharmacology of Chinese herbs, CRC Press. Inc., p 289, 1993). .

Golden (Scutellariae Radix) is the bark of the bark of Scutellaria baicalensis Georgi. The main ingredients of gold include baicalein, baicalin, wogomin and B-sitosterol. Gold has antibacterial effects against staphylococci, cholera, typoid, paratyphoid, dysentery, diphtheria, hemolytic staphylococci, coliforms, pneumococci, and spiral bacteria. And it shows an antiviral effect with respect to influenza virus. Baikal, the main component of gold, is used to treat upper respiratory tract infections such as acute tonsillitis and pharyngitis, scarlet fever, viral hepatitis, nephritis, and pelvic inflammatory disease (Huang KC, The pharmacology of Chinese herbs, CRC Press. Inc., p 290). , 1993).

Gardenia (Gardeniae Fructus) is the fruit of Gardenia jasmoides Ellis or other similar plants. Gardenia is known to have liver detoxification action, bile secretion promoting action, gastric juice secretion, gastrointestinal movement promoting action, central nervous system action, and blood pressure lowering action. It also exhibits antimicrobial activity against staphylococcus aureus, Diplococcus meningitids, and Neisseria (Zhu, You-Ping, Chinese Materia Medica, Harwood Academic Publisher, p 117, 1988).

Bacterial enteritis and coccidiosis are natural antibiotics, in addition to natural antibiotics, the natural substance having a buccal action is effective in the prevention and treatment of bacterial enteritis and coccidiosis. Natural herbal medicines conventionally known to have a long-term branch action or antimicrobial activity include turmeric, peony, rhubarb, and Gaza.

Curcumae Rhizoma is the root stem of Curcuma longa L. that has been dried or steamed as it has been removed. It is reported that it contains a tumeone (tumerone) etc. as an essential oil component, and curcumin (curcumine) etc. as a yellow pigment component, and it is reported that it has a long-term branch action, aromatic dry stomach, pain, hemostasis, and soothing effect.

Peony (Paeoniae Radix) is dried root of Peony (Peonia lactiflora) and related plant as it is or by removing the bark. Peony is a pharmacological ingredient containing paeoniflorine (paeoniflorine) and paeoniflorigenone (paeoniflorigenone), etc., is known to have affairs, analgesic, analgesic, and astringent action.

Rhei Rhizoma is the root of Rheum palmatum L. Rhubarb contains as an pharmacologically active ingredient senthoxide A-F and anthraquinone derivatives, which are dianthrone glycosides. Rhubarb is known to exhibit antimicrobial activity against Staphylococcus aureus and have a healthy action.

The terminaliae fructus is the fruit of the terminalia chebula Retzius, the combreaaceae. As pharmacologically active ingredients, tannin, chebulinic acid, chebulagic acid, chebulin, chebulin, terchebin and the like are contained. Gaza is known to have intestinal antibacterial action, antiviral action, astringent action and antifungal action.

Accordingly, the present inventors recognize the necessity of the development of natural antibiotics for preventing or treating bacterial enteritis and coccidiosis in livestock and poultry and promoting growth, and the prevention or treatment of cheap and sufficient bacterial enteritis and coccidiosis for practical use. Efforts have been made to develop combinations of complex natural herbs that can be represented, thus completing the present invention.

Accordingly, it is an object of the present invention to provide a composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry comprising a combination of natural herbal medicines.

In order to achieve the above object, the present invention provides a composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, including turmeric, yellow lotus, gold, yellow white, gardenia, peony, rhubarb, and Gaza.

Hereinafter, the present invention will be described in more detail.

The present invention is a combination of turmeric, yellow lotus, golden, yellow white, gardenia, peony, rhubarb, and Gaza, which are known in the art for antimicrobial activity or sedimentation, to prevent or treat bacterial enteritis or coccidiosis in livestock and poultry, respectively. It was the first discovery that it produces synergistic effects than when used alone.

Accordingly, the present invention provides a composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, including turmeric, yellow lotus, gold, yellow white, gardenia, peony, rhubarb, and Gaza as active ingredients.

The inventors also note that the composition according to the present invention is 15 to 18% by weight of turmeric, 8 to 12% by weight of sulfur, 8 to 12% by weight of gold, 10 to 15% by weight of sulfur and 8 to 12% of gardenia. %, Peony is 8 to 12% by weight, rhubarb is 15 to 18% by weight, Gaza 8 to 12% by weight, it is more effective in the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry Found.

Therefore, the composition according to the present invention is preferably 15 to 18% by weight of turmeric, 8 to 12% by weight of sulfur, 8 to 12% by weight of gold, 10 to 15% by weight of sulfur and 8 to 12% of gardenia. %, Peony is 8 to 12% by weight, rhubarb may be included in the ratio of 15 to 18% by weight, Gaza 8 to 12% by weight.

Each of the compositions according to the present invention, constituents of turmeric, rhubarb, gold, yellow white, gardenia, peony, rhubarb, and Gaza are included in the form of extracts obtained by conventional extraction methods known in the art, or It can be included as a dry mill.

The extracts of turmeric, rhubarb, gold, yellowish white, gardenia, peony, rhubarb, and Gaza obtained by the conventional extraction method may be extracts of water, ethanol, or a mixed solvent thereof. At the time of extraction, the extraction may be performed more efficiently by applying ultrasonic waves or heating. These extracts may be used as they are, but may be concentrated and then lyophilized.

The composition for the prophylaxis or treatment of bacterial infectious diseases or inflammatory diseases, including turmeric, yellow lotus, gold, yellow white, gardenia, peony, rhubarb, and Gaza according to the present invention described above is intended for administration to livestock and poultry. It is preferable to formulate it in the form of a powder, a liquid (e.g. extract, a whole), granules or tablets. In this case, it can be formulated by selecting and adding a pharmaceutically acceptable carrier in addition to the extracts or milled products of the turmeric, rhubarb, golden, yellow white, gardenia, peony, rhubarb, and Gaza.

Pharmaceutically acceptable carriers that can be used in the formulation may be used by selecting one or more of diluents, lubricants, binders, disintegrants, sweeteners, stabilizers, preservatives.

The carrier and the additive may be any pharmaceutically acceptable, and specifically, lactose, corn starch, soybean oil, microcrystalline cellulose, or mannitol as a diluent, magnesium stearate or talc as a lubricant, and polyvinylpyrrolidone as a binder. Or hydroxypropyl cellulose may be used, but is not limited thereto. In addition, as the disintegrant, calcium carboxymethyl cellulose, sodium starch glycolate, potassium polyacrylic acid, or crospovidone, methyl paraoxybenzoate, propyl paraoxybenzoate, or potassium sorbate may be used as the preservative, but is not limited thereto. It is not.

When prepared in liquid form, it may be necessary to use preservatives such as sorbate potassium, methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate, antioxidants such as ascorbic acid and fragrance enhancers such as peppermint oil. And for further examples of adjuvants, see Dr. HP Fiedler "Lexikon der Hilfsstoffe fur Pharmazie, Kosmetik und angrenzende Gebiete" [Encyclopaedia of auxiliaries for pharmacy, cosmetics and related fields].

The composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry according to the present invention, in order to obtain a prophylactic or therapeutic effect of bacterial enteritis or coccidiosis, the turmeric, rhubarb, gold, yellow white, gardenia, peony, rhubarb, And combinations of Gaza may be administered to livestock or poultry on an amount of 250 to 1500 mg / kg per day, based on the dry herb, but such dosage may be for the type, prevention or treatment of the specific bacterial enteritis or coccidiosis to be prevented or treated. Those skilled in the art can appropriately control the type of animal, bacterial enteritis or coccidiosis progression, animal age, animal weight, and the like.

Livestock that can be used for the composition for preventing or treating bacterial enteritis or coccidiosis according to the present invention typically includes cattle, pigs, or goats, and poultry includes, but is not limited to, chicken, duck, or turkey.

In addition, the composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, including turmeric, rhubarb, gold, yellow white, gardenia, peony, rhubarb, and Gaza according to the present invention is effective for It can be used to prevent or treat diseases of any livestock and poultry which can be prevented or treated by such diseases as, for example, salmonella, proliferative ileitis, colitis, piglet, and various Eimeria protozoa. acervulina, Eimeria brunetti, Eimeria maxima, Eimeria necatrix, Eimeria tenella), but may be selected from the group consisting of coccidiosis.

The composition according to the invention is effective in promoting the growth of livestock and poultry as well as preventing or treating bacterial enteritis or coccidiosis of livestock and poultry. This growth promoting effect is a secondary effect obtained by the composition according to the invention due to the prophylactic or therapeutic effect of bacterial enteritis or coccidiosis.

The composition for the prevention or treatment of bacterial enteritis or coccidiosis, including turmeric, sulfur, golden, yellow, yellow, gardenia, peony, rhubarb, and Gaza according to the present invention, may be directly administered to livestock or poultry, but is added to feed as a feed additive. It may also be administered indirectly.

The composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, including turmeric, yellow lotus, golden, yellow white, gardenia, peony, rhubarb, and Gaza, according to the present invention is conventionally antimicrobial, Combination of known herbal medicines has shown a prophylactic and therapeutic effect on synergistic bacterial enteritis and coccidiosis than when used alone, and can be effectively used for the prevention or treatment of various bacterial enteritis and coccidiosis in livestock and poultry in the field of organic livestock. Can be. In addition, the composition for preventing or treating bacterial enteritis or coccidiosis of livestock and poultry according to the present invention makes it possible to replace antibiotics that have been used conventionally with natural herbs, thereby producing high quality livestock and aquatic products not contaminated with antibiotics. It can solve the problem of cross resistance between livestock pathogens and human pathogens, which were concerned about the abuse of antibiotics, and prevent the occurrence of environmental pollution due to the use of antibiotics in the livestock raising process.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these examples are only for the understanding of the present invention, and the scope of the present invention is not limited by them in any sense.

Example  1: bacterial enteritis according to the present invention or Coccidiosis  Prophylactic or therapeutic compositions (1)

45 g turmeric, 30 g rhubarb, 30 g golden, 35 g white yellow, 30 g gardenia, 30 g peony, 45 g rhubarb, and 30 g Gaza, respectively, are ground using a hammer mill and then in a mixer. Mix homogeneously.

Comparative example  One : Turmeric  Ethanol extract

An appropriate amount of 70% ethanol was added to 45 g of dried turmeric, and ultrasonic extraction was performed three times for 15 minutes, and the mixture was filtered and concentrated under reduced pressure. The concentrate was lyophilized to give a weakly lyophilized powder.

Comparative example  2 : Ruddy  Ethanol extract

A freeze-dried powder of sulfur was obtained in the same manner as in Comparative Example 1, except that 30 g of dried yellow lotus was used instead of dried turmeric in Comparative Example 1.

Comparative example  3: Golden Ethanol Extract

A freeze-dried powder of golden color was obtained in the same manner as in Comparative Example 1 except that 30 g of dried golden grass was used instead of dried turmeric in Comparative Example 1.

Comparative example  4 : Yellow-white  Ethanol extract

A freeze-dried powder of sulfur white was obtained in the same manner as in Comparative Example 1 except that 35 g of dried sulfur white was used instead of dried turmeric in Comparative Example 1.

Comparative example  5: Gardenia ethanol extract

A freeze-dried powder of gardenia was obtained in the same manner as in Comparative Example 1, except that 30 g of dried gardenia was used instead of dried turmeric in Comparative Example 1.

Comparative example  6: Peony ethanol extract

A freeze-dried powder of the peony was obtained in the same manner as in Comparative Example 1 except that 30 g of the dried peony was used instead of the dried turmeric in Comparative Example 1.

Comparative example  7: Rhubarb  Ethanol extract

A freeze-dried powder of rhubarb was obtained in the same manner as in Comparative Example 1, except that 45 g of dried rhubarb was used instead of dried turmeric in Comparative Example 1.

Comparative example  8 : Gaza  Ethanol extract

A freeze-dried powder of Gaza was obtained in the same manner as in Comparative Example 1, except that 30 g of dried Gaza was used instead of dried Turmeric in Comparative Example 1.

Example  2: bacterial enteritis according to the invention or Coccidiosis  Prophylactic or therapeutic compositions

The freeze-dried powders of each of the ethanol extracts prepared in Comparative Examples 1 to 8 were all homogeneously mixed in a mixer to prepare a composition according to the present invention.

Formulation Example

1. Premise

Turmeric 45 g, rhubarb 30 g, golden 30 g, sulfur white 35 g, gardenia 30 g, peony 30 g, rhubarb 45 g, and 30 g of Gaza are cut out or cut into a pre-precipitator, add 1 L of purified water, and stir several times. Heated for 30 minutes. The combined mixture of heated herbal medicines was filtered anonymously and the total amount was made 2 L by adding an appropriate amount of purified water.

2. X

A combination of 45 g of turmeric, 30 g of rhubarb, 30 g of gold, 35 g of yellow white, 30 g of gardenia, 30 g of peony, 45 g of rhubarb, and 30 g of Gaza was powdered, and then water was added and leached by the percolation method. The leachate was filtered, concentrated under reduced pressure, lyophilized and ground to prepare a homogeneous powder.

3. Granule

Water was added to the prepared X agent and mixed homogeneously, and then passed through a sieve of about 10 mesh to prepare a granule. Formulated granules were prepared by drying at a temperature of 50 ° C. in a hot air dryer.

Claims (9)

Composition for the prevention or treatment of bacterial enteritis or coccidiosis of livestock and poultry, including turmeric, sulfur, golden, yellow white, gardenia, peony, rhubarb, and Gaza. According to claim 1, wherein the turmeric is 15 to 18% by weight, sulfur is 8 to 12% by weight, gold is 8 to 12% by weight, sulfur is 10 to 15% by weight, gardenia is 8 to 12% by weight, peony is 8 To 12% by weight, rhubarb is 15 to 18% by weight, Gaza is characterized in that it comprises a ratio of 8 to 12% by weight. The composition of claim 1, wherein the turmeric, rhubarb, golden, yellowish white, gardenia, peony, rhubarb, and gaza are extracts of water, ethanol, or a mixed solvent thereof. The composition of claim 1, wherein the turmeric, rhubarb, golden, yellowish white, gardenia, peony, rhubarb, and Gaza are ground powders of dried herbal medicine. The composition according to any one of claims 1 to 4, wherein the livestock is cow, pig, or goat. 5. The composition of claim 1, wherein the poultry is chicken, duck, or turkey. 6. The composition according to any one of claims 1 to 4, which is effective in promoting the growth of livestock and poultry. The composition according to any one of claims 1 to 4, which is in the form of a powder, a whole preparation, a extractant, a granule or a tablet. The composition according to any one of claims 1 to 4, which is used as a feed additive for livestock and poultry.