CN104800569A - Traditional Chinese medicine oral liquid for treating bacterial enteritis of fishes and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for treating bacterial enteritis of fishes and preparation method thereof Download PDFInfo
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- CN104800569A CN104800569A CN201510195175.7A CN201510195175A CN104800569A CN 104800569 A CN104800569 A CN 104800569A CN 201510195175 A CN201510195175 A CN 201510195175A CN 104800569 A CN104800569 A CN 104800569A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention relates to a traditional Chinese medicine oral liquid for treating bacterial enteritis of fishes and a preparation method thereof. The traditional Chinese medicine oral liquid is prepared from the root of kudzu vine, amur corktree bark, coptis chinensis, Chinese pulsatilla roots, ash bark, bletilla striata and tree peony bark. The traditional Chinese medicine composition can be oral liquid. The traditional Chinese medicine oral liquid is prepared through the following steps: (1), smashing traditional Chinese medicines to 60-80 meshes, weighing according to the formula ratio, and three-dimensionally mixing to obtain traditional Chinese medicine powder; (2), feeding the mixed traditional Chinese medicine powder and 300-600 parts of water into an extracting tank respectively for soaking for 5-20 h; (3), heating to 40-100 DEG C and extracting for 10-15 h; (4), filtering and collecting a medical solution; (5), continuously adding 300-600 parts of water into rest medicine dregs and extracting for 10-15 h at 40-100 DEG C; (6), filtering to remove medicine dregs, mixing the two extracting solutions, concentrating the mixed extracting solution at 30-70 DEG C under reduced pressure until the volume of the mixed extracting solution is 10%-20% of original volume; (7), filling bottles with the concentrated extracting solution in a manner that each bottle is filled with 250 ml of the concentrated extracting solution, so as to obtain the finished product. The traditional Chinese medicine oral liquid provided by the invention can effectively treat bacterial enteritis of fishes, and the cure rate reaches 90% or above. The traditional Chinese medicine oral liquid has the effects of clearing heat, stopping dysentery, cooling blood and hemostasis, promoting spleen yang and stopping diarrhea.
Description
Technical field
The invention belongs to Chinese veterinary drug preparation field, especially a kind ofly treat Chinese medicine oral liquid of fish bacterial enteritis and preparation method thereof.
Background technology
Fish bacterial enteritis disease is a kind of infectious disease specially referred to caused by pathogenic entero becteria, and China respectively cultivates area all has generation.Cause of disease visible peristalsis visible intestinal peristalsis Aeromonas punctata, suitable growth temperature is 25 DEG C, and more than 60 DEG C dead, and pH value all can grow 6 ~ 12 time.
Ctenopharyngodon idellus, the most susceptible disease of Mylopharyngodon piceus, Cyprinus carpio, flathead also have morbidity.Fashionable colors is April ~ October, and water temperature comes into vogue 18 DEG C time, and epidemic peak is water temperature 25 DEG C ~ 30 DEG C.When worsening condition, fish body resistance decline, visible peristalsis visible intestinal peristalsis Aeromonas punctata, at enteral amount reproduction, just can cause outbreak of disease.Sick fish peels off and solely swims, and body colour is turned black, and loss of appetite is not so that eat food completely, and the normal red and swollen evagination of hepatic portal, has yellow mucus to flow out from anus.Cut fish belly open, early stage visible intestinal wall hyperemia be rubescent, swelling inflammation, do not have food in enteric cavity or only have a small amount of food in the rear end of intestinal, enteral has more yellow or yellowish red color mucus.End-stage disease, visible full enteremia inflammation, intestinal wall takes on a red color or aubergine, and rear intestinal segment is obvious, and intestinal mucosa often festers and comes off, and mixes with blood, is filled in intestinal tube.
The hyperemia of clinical diagnosis common intestinal is rubescent, and rear intestinal segment is obvious, and anus is red and swollen, evagination, has a lot of faint yellow mucus in enteric cavity.Aerogenesis pseudomonas bacillus can be detected from liver, kidney or blood.
Current China advocates green cultivation energetically, the antibiotic use of strict control.Therefore develop the tcm product for fish bacterial enteritis, become an urgent demand of veterinary drug development field.
Summary of the invention
The problem to be solved in the present invention is: overcome the deficiencies in the prior art, provides a kind of good effect, no drug residue, safe and reliable treatment fish bacterial enteritis Chinese medicine oral liquid.
Another technical problem that the present invention will solve is: provide a kind of Chinese medicine formula for the treatment of fish bacterial enteritis.
Another technical problem that the present invention will solve is: the preparation method providing the oral liquid formulations of above-mentioned pig Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is: a kind of Chinese medicine composition for the treatment of fish bacterial enteritis, is prepared from by the raw material of following mass fraction: Radix Puerariae 20-40 part, Cortex Phellodendri 20-40 part, Rhizoma Coptidis 20-40 part, Radix Pulsatillae 20-40 part, Cortex Fraxini 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Cortex Moutan 20-40 part.
Further, the mass fraction of the optimum feed stock of this Chinese medicine composition is as follows:
Radix Puerariae 40 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 30 parts, the Radix Pulsatillae 30 parts, Cortex Fraxini 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Cortex Moutan 20 parts.
Further, this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
Further, the preparation method of the oral liquid formulations of said composition is: Chinese medicine powder is broken to 60-80 order by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 300-600 part water are put in extraction pot respectively, soak 5-20 hour; (3) be heated to 40-100 DEG C and extract 10-15 hour; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 300-600 part water, and 40-100 DEG C is extracted 10-15 hour; (6) excessively filter medicinal residues, merge extracted twice liquid, 30-70 DEG C is evaporated to original volume 10%-20%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
The advantage that the present invention has and good effect are:
(1) the present invention is according to tcm theory, and scientific compatibility, remains the combined effect of Chinese medicinal formulae determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, through clinical verification determined curative effect, is a kind of green veterinary drug of nuisanceless, no drug residue.
(2) Chinese medicine ingredients that the present invention contains can effectively treat fish bacterial enteritis, and cure rate can reach more than 90%.This prescription has the effect of clearing away heat to cure dysentery, cooling blood for hemostasis, yang invigorating antidiarrheal.
(3) pharmacology of each raw material of Chinese medicine of the present invention is:
Radix Puerariae: yang invigorating antidiarrheal;
Cortex Phellodendri: heat clearing and damp drying;
Rhizoma Coptidis: heat clearing and damp drying, eliminating fire and detoxication;
The Radix Pulsatillae: heat-clearing and toxic substances removing, antidiarrheal
Cortex Fraxini: heat clearing and damp drying, astringent therapy;
The Pseudobulbus Bletillae (Rhizoma Bletillae): hemostasis;
Cortex Moutan: cooling blood for hemostasis;
We's Radix Puerariae, Cortex Phellodendri, Rhizoma Coptidis, the Radix Pulsatillae, Cortex Fraxini share, and can play heat clearing and damp drying, effect of yang invigorating antidiarrheal.Can antidiarrheal rapidly.The Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Moutan are matched, cooling blood for hemostasis, hemafecia, mucosa are just had to the effect of getting instant result.
Detailed description of the invention
Below by specific embodiment, the invention will be further described, and following examples are descriptive, is not determinate, can not limit protection scope of the present invention with this.
Embodiment 1
A Chinese medicine oral liquid for treatment fish bacterial enteritis, the parts by weight of each raw material are as follows: Radix Puerariae 40 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 30 parts, the Radix Pulsatillae 30 parts, Cortex Fraxini 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Cortex Moutan 20 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product.
Embodiment 2
A Chinese medicine oral liquid for treatment fish bacterial enteritis, the parts by weight of each raw material are as follows: Radix Puerariae 30 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 20 parts, the Radix Pulsatillae 40 parts, Cortex Fraxini 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Cortex Moutan 20 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Embodiment 3
A Chinese medicine oral liquid for treatment fish bacterial enteritis, the parts by weight of each raw material are as follows: Radix Puerariae 30 parts, Cortex Phellodendri 30 parts, Rhizoma Coptidis 30 parts, the Radix Pulsatillae 30 parts, Cortex Fraxini 30 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 20 parts, Cortex Moutan 30 parts.Its preparation method is: Chinese medicine powder is broken to 80 orders by (1), takes by formula ratio, and three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder and 500 parts of water are put in extraction pot, soak 10 hours; (3) be heated to 100 DEG C extract 12 hours; (4) collecting by filtration medicinal liquid; (5) remaining medicinal residues continue to add 500 parts of water, and 100 DEG C are extracted 12 hours; (6) excessively filter medicinal residues, merge extracted twice liquid, 60 DEG C are evaporated to original volume 10%; (7) fill becomes bottle, and every bottle of 250ml, gets product
Clinical trial
Experimental example:
Fish pond, Shandong, there is bacterial enteritis in each 30000 tails of two pool Ctenopharyngodon idellus.The hyperemia of clinical manifestation intestinal is rubescent, and rear intestinal segment is obvious, and anus is red and swollen, evagination, has a lot of faint yellow mucus in enteric cavity.Product obtained by embodiment 1 is used to wherein 1 pool.Every bottle of spice 100 kilograms, once a day, treats three days.Medication second day symptom is obviously alleviated, recovery from illness in the 3rd day.After drug withdrawal, do not occur repeatedly.Cure rate reaches 95%, does not occur death.Another 1 pool uses gentamycin, and treatment three days, fails to control the state of an illness continuously, death every day 200-400 tail.After use embodiment 1 products made thereby instead, control death after three days, jumpbogroup fully recover.
Experiment proves that product obtained by embodiment 1 subtracts effect fast, determined curative effect, not easily repeatedly.
The above, be only preferred embodiments of the present invention, is illustrative instead of determinate, can list several embodiments according to limited range, therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. treat Chinese medicine oral liquid of fish bacterial enteritis and preparation method thereof for one kind, it is characterized in that: be prepared from by the raw material of following mass fraction: Radix Puerariae 20-40 part, Cortex Phellodendri 20-40 part, Rhizoma Coptidis 20-40 part, Radix Pulsatillae 20-40 part, Cortex Fraxini 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Cortex Moutan 20-40 part.
2. the Chinese medicine oral liquid for the treatment of fish bacterial enteritis according to claim 1, is characterized in that: the mass fraction of optimum feed stock is as follows:
Radix Puerariae 20-40 part, Cortex Phellodendri 20-40 part, Rhizoma Coptidis 20-40 part, Radix Pulsatillae 20-40 part, Cortex Fraxini 20-40 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 20-40 part, Cortex Moutan 20-40 part.
3. the Chinese medicine oral liquid for the treatment of fish bacterial enteritis according to claim 1 and 2, is characterized in that: this Chinese medicine composition is the various conventional extract oral medicine dosage form containing or do not contain pharmaceutic adjuvant.
4. the Chinese medicine oral liquid for the treatment of fish bacterial enteritis according to claim 3, is characterized in that: described preparation can be oral liquid.
5. prepare a method for the Chinese medicine oral liquid for the treatment of fish bacterial enteritis as claimed in claim 4, it is characterized in that: preparation method is that Chinese medicine powder is broken to certain order number by (1), and take by formula ratio, three-dimensional hybrid obtains Chinese medicine powder; (2) mixed Chinese medicine powder, aqueous solution are put in extraction pot respectively, soak the regular hour; (3) be heated to uniform temperature, extract certain hour; (4) collecting by filtration extracting solution; (5) secondary adds a certain amount of water in medicinal residues, continues to extract certain hour at a certain temperature; (6) merge extracted twice liquid, be evaporated to certain volume at a certain temperature; (7) fill becomes bottle, gets product.
6. the preparation method of the Chinese medicine oral liquid for the treatment of fish bacterial enteritis according to claim 5, is characterized in that: described pulverizing order number is 60-80 order.
7. the preparation method of the Chinese medicine oral liquid for the treatment of fish bacterial enteritis according to claim 5, is characterized in that: the extracted twice time is 10-15 hour.
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| CN201510195175.7A CN104800569A (en) | 2015-04-22 | 2015-04-22 | Traditional Chinese medicine oral liquid for treating bacterial enteritis of fishes and preparation method thereof |
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| CN201510195175.7A CN104800569A (en) | 2015-04-22 | 2015-04-22 | Traditional Chinese medicine oral liquid for treating bacterial enteritis of fishes and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927330A (en) * | 2017-11-21 | 2018-04-20 | 山东省海洋生物研究院 | A kind of Chinese herbal feed additive for treating fish enteritis |
Citations (3)
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| KR20090094616A (en) * | 2008-03-03 | 2009-09-08 | 김충정 | Compositions for preventing or treating bacterial enteritis or Coccidiosis |
| CN103550354A (en) * | 2013-10-30 | 2014-02-05 | 福建农林大学 | Compound stomach-invigorating and intestine-treating granules for fishes and preparation method thereof |
| CN104173743A (en) * | 2014-08-18 | 2014-12-03 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for treating bacterial gill-rot disease of ctenopharyngodon idellus and preparation method thereof |
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2015
- 2015-04-22 CN CN201510195175.7A patent/CN104800569A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090094616A (en) * | 2008-03-03 | 2009-09-08 | 김충정 | Compositions for preventing or treating bacterial enteritis or Coccidiosis |
| CN103550354A (en) * | 2013-10-30 | 2014-02-05 | 福建农林大学 | Compound stomach-invigorating and intestine-treating granules for fishes and preparation method thereof |
| CN104173743A (en) * | 2014-08-18 | 2014-12-03 | 格特生物制药（天津）有限公司 | Traditional Chinese medicine oral liquid for treating bacterial gill-rot disease of ctenopharyngodon idellus and preparation method thereof |
Non-Patent Citations (2)
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| 唐亮华等: "中西医结合治疗耕牛下痢", 《广东畜牧兽医科技》 * |
| 张颖等: "白头翁汤加味保留灌肠治疗慢性肠道疾病", 《吉林中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107927330A (en) * | 2017-11-21 | 2018-04-20 | 山东省海洋生物研究院 | A kind of Chinese herbal feed additive for treating fish enteritis |
| CN107927330B (en) * | 2017-11-21 | 2020-02-14 | 山东省海洋生物研究院 | Chinese herbal medicine feed additive for treating fish enteritis |
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