CN111135210A - Production method of medicine for treating African swine fever - Google Patents
Production method of medicine for treating African swine fever Download PDFInfo
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- CN111135210A CN111135210A CN201911231638.5A CN201911231638A CN111135210A CN 111135210 A CN111135210 A CN 111135210A CN 201911231638 A CN201911231638 A CN 201911231638A CN 111135210 A CN111135210 A CN 111135210A
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- 239000003814 drug Substances 0.000 title claims abstract description 34
- 208000007407 African swine fever Diseases 0.000 title claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- 239000000463 material Substances 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000007873 sieving Methods 0.000 claims description 16
- 244000274050 Platycodon grandiflorum Species 0.000 claims description 15
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 15
- 238000001035 drying Methods 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 12
- 239000007779 soft material Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000282898 Sus scrofa Species 0.000 claims description 6
- 208000021760 high fever Diseases 0.000 claims description 6
- 241000205585 Aquilegia canadensis Species 0.000 claims description 3
- 244000260524 Chrysanthemum balsamita Species 0.000 claims description 3
- 235000005633 Chrysanthemum balsamita Nutrition 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 241000893536 Epimedium Species 0.000 claims description 3
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 3
- 240000004534 Scutellaria baicalensis Species 0.000 claims description 3
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 235000018905 epimedium Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 235000011477 liquorice Nutrition 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 5
- 230000000694 effects Effects 0.000 abstract description 7
- 208000003322 Coinfection Diseases 0.000 abstract description 6
- 241000282887 Suidae Species 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 description 7
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229960003022 amoxicillin Drugs 0.000 description 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000032625 disorder of ear Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- UURAUHCOJAIIRQ-QGLSALSOSA-N tiamulin Chemical compound CCN(CC)CCSCC(=O)O[C@@H]1C[C@@](C)(C=C)[C@@H](O)[C@H](C)[C@@]23CC[C@@H](C)[C@]1(C)[C@@H]2C(=O)CC3 UURAUHCOJAIIRQ-QGLSALSOSA-N 0.000 description 1
- 229960004885 tiamulin Drugs 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a method for producing a medicament for treating African swine fever, the medicament prepared by the steps of the invention can be mixed into feed to be orally taken by pigs, so that the stress effect is avoided, and the medicament contains a plurality of traditional Chinese medicine components, can effectively correspond to the mixed infection of African swine fever, and is clinically proved to be capable of effectively controlling the outbreak of the African swine fever, and has small side effect and difficult generation of medicament resistance.
Description
Technical Field
The invention relates to the field of medicines, in particular to a production method of a medicine for treating African swine fever.
Background
The African swine fever is an acute, febrile, highly pathogenic and highly lethal infectious disease caused by the mixture of other viruses such as a blue-ear disease virus and other viruses, bacteria, parasites and other multiple pathogens or secondary infection because the immune system of a pig loses the normal immune function after being inhibited, so that the African swine fever is difficult to control clinically and the treatment effect is not ideal. The african swine fever medicine is used for reducing the stress action of pigs as much as possible, oral administration medicines are adopted as far as possible, and the existing medicines for treating the african swine fever mainly comprise antibiotics such as amoxicillin, tiamulin and the like and antipyretic medicines, but the medicines have certain defects that the use of the antibiotics easily causes drug resistance and secondary infection, the residue of veterinary medicines in pork products easily exceeds the standard, and the repeated large-dose injection of the antibiotics and the antipyretic medicines also increases the death rate of the pigs (refer to the literature: the treatment measures for high fever of the pigs, namely Chunyuan-shou). Moreover, the pathogen of African swine fever belongs to mixed infection, and the disease condition is difficult to control by a single western medicine.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a production method of a medicine for treating African swine fever by taking traditional Chinese medicines as raw materials.
The technical scheme adopted by the invention for solving the problems is as follows: a production method of a medicine for treating African swine fever comprises the following steps:
s1, weighing raw medicinal materials according to the proportion of 30-120 parts of platycodon grandiflorum, 30-240 parts of honeysuckle, 50-200 parts of radix scutellariae, 20-100 parts of liquorice, 50-200 parts of epimedium and 40-150 parts of purple daisy;
s2, crushing and sieving the raw medicinal materials in the step S1;
s3, adding eight times of water into each raw medicinal material obtained in the step S2 to soak for 0.8-1.5 hours;
s4, decocting the other raw medicinal materials except the platycodon grandiflorum soaked in the S3 for two times respectively, wherein the first decocting time is 2-2.5 hours, and the second decocting time is 0.75-1.25 hours, and the scutellaria baicalensis is added into the decoction after the water is boiled;
s5, filtering the medicinal materials decocted in the step S4 to obtain filtrate of the medicinal materials respectively while the medicinal materials are hot;
s6, extracting the platycodon grandiflorum for a plurality of times at high temperature by adopting four times of 70% ethanol and a reflux extractor, and then recovering ethanol by stewing and refluxing to obtain a platycodon grandiflorum filtrate;
s7, merging and mixing the filtrates obtained in the steps S5 and S6, and standing for more than 12 hours;
s8, carrying out reduced pressure concentration on the filtrate obtained after standing in the step S7, heating and drying the filtrate into a thick paste, and then uniformly mixing dextrin and sugar;
s9, drying and crushing the product obtained in the step S8, and sieving the product;
s10, mixing the products sieved in the step S9 to prepare soft materials, sieving the soft materials, and drying the soft materials until the water content is 4% -6%, thereby preparing the granular materials.
As a further improvement of the technical scheme, a 24-mesh sieve is adopted for sieving in the step S2.
As a further improvement of the above technical solution, in step S7, the platycodon grandiflorum is extracted four times with 70% ethanol at high temperature using a reflux extractor for 1.3-1.7 hours each time.
As a further improvement of the technical scheme, a 100-mesh sieve is adopted for sieving in the step S9.
As a further improvement of the technical proposal, a 16-mesh sieve is adopted for sieving in the step S10.
As a further improvement of the technical proposal, the drying in the step S10 is carried out at the temperature of 60-70 ℃.
The invention has the beneficial effects that: the medicine prepared by the steps of the invention can be mixed into feed to enable pigs to eat orally, so that the stress effect is avoided, and the medicine contains various traditional Chinese medicine components, can effectively correspond to the mixed infection of African swine fever, and is clinically proved to be capable of effectively controlling the attack of African swine fever, small in side effect and not easy to generate drug resistance.
Detailed Description
A production method of a medicine for treating African swine fever disease comprises the following steps:
s1, weighing raw medicinal materials according to the proportion of 30-120 parts of platycodon grandiflorum, 30-240 parts of honeysuckle, 50-200 parts of radix scutellariae, 20-100 parts of liquorice, 50-200 parts of epimedium and 40-150 parts of purple daisy;
s2, crushing and sieving the raw medicinal materials in the step S1;
s3, adding eight times of water into each raw medicinal material obtained in the step S2 to soak for 0.8-1.5 hours;
s4, decocting the other raw medicinal materials except the platycodon grandiflorum soaked in the S3 for two times respectively, wherein the first decocting time is 2-2.5 hours, and the second decocting time is 0.75-1.25 hours, and the scutellaria baicalensis is added into the decoction after the water is boiled;
s5, filtering the medicinal materials decocted in the step S4 to obtain filtrate of the medicinal materials respectively while the medicinal materials are hot;
s6, extracting the platycodon grandiflorum for a plurality of times at high temperature by adopting four times of 70% ethanol and a reflux extractor, and then recovering ethanol by stewing and refluxing to obtain a platycodon grandiflorum filtrate;
s7, merging and mixing the filtrates obtained in the steps S5 and S6, and standing for more than 12 hours;
s8, carrying out reduced pressure concentration on the filtrate obtained after standing in the step S7, heating and drying the filtrate into a thick paste, and then uniformly mixing dextrin and sugar;
s9, drying and crushing the product obtained in the step S8, and sieving the product;
s10, mixing the products sieved in the step S9 to prepare soft materials, sieving the soft materials, and drying the soft materials until the water content is 4% -6%, thereby preparing the granular materials.
The medicine prepared by the steps of the invention can be mixed into feed to enable pigs to eat orally, so that the stress effect is avoided, and the medicine contains various traditional Chinese medicine components, can effectively correspond to the mixed infection of African swine fever, and is clinically proved to be capable of effectively controlling the outbreak of African swine fever, and the medicine has small side effect and is not easy to generate drug resistance.
In the above step, the sieving in step 2 is preferably performed with a 24-mesh sieve, and in step S9, in order to more thoroughly pulverize the product, it is preferably performed with a 100-mesh sieve.
In step S10, because the soft material is added, mixed, dried and sieved, and the finished product has a certain moisture content, a 16-mesh sieve is preferably used.
Further modified, in step S7, the extraction of platycodon grandiflorum is performed preferably four times using 70% ethanol in four times amount and using a reflux extractor at high temperature, each time for 1.3 to 1.7 hours.
Further, it is preferable that the drying step in step S10 is performed at a temperature of 60 to 70 ℃ in order to prevent the medicine from being scorched.
The above is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structural changes made by using the content of the present specification, or directly or indirectly applied to other related technical fields, under the inventive concept of the present invention, are included in the scope of the present invention.
Claims (6)
1. The production method of the medicine for treating the African swine fever is characterized by comprising the following steps:
s1, weighing raw materials according to the proportion of 30-120 parts of platycodon grandiflorum, 30-240 parts of honeysuckle, 50-200 parts of radix scutellariae, 20-100 parts of liquorice, 50-200 parts of epimedium and 40-150 parts of purple daisy;
s2, crushing and sieving the raw medicinal materials in the step S1;
s3, adding eight times of water into each raw medicinal material obtained in the step S2 to soak for 0.8-1.5 hours;
s4, decocting the other raw medicinal materials except the platycodon grandiflorum soaked in the S3 for two times respectively, wherein the first decocting time is 2-2.5 hours, and the second decocting time is 0.75-1.25 hours, and the scutellaria baicalensis is added to be decocted after water is boiled;
s5, filtering the medicinal materials decocted in the step S4 to obtain filtrate of the medicinal materials respectively while the medicinal materials are hot;
s6, extracting the platycodon grandiflorum for a plurality of times at high temperature by adopting four times of 70% ethanol and a reflux extractor, and then recovering ethanol by stewing and refluxing to obtain platycodon grandiflorum filtrate;
s7, merging and mixing the filtrates obtained in the steps S5 and S6, and standing for more than 12 hours;
s8, carrying out reduced pressure concentration on the filtrate obtained after standing in the step S7, heating and drying the filtrate into a thick paste, and then uniformly mixing dextrin and sugar;
s9, drying and crushing the product obtained in the step S8, and sieving the product;
s10, mixing the products sieved in the step S9 to prepare soft materials, sieving the soft materials, and drying the soft materials until the water content is 4% -6%, thereby preparing the granular materials.
2. The method for producing a medicament for treating swine high fever according to claim 1, wherein the method comprises the steps of:
in the step S2, a 24-mesh sieve is used for sieving.
3. The method for producing a medicament for treating swine high fever according to claim 1, wherein the method comprises the steps of:
in step S7, the platycodon grandiflorum is extracted four times with 70% ethanol at high temperature using a reflux extractor for 1.3 to 1.7 hours each time.
4. The method for producing a medicament for treating swine high fever according to claim 1, wherein the method comprises the steps of:
in step S9, 100 mesh sieve is used for sieving.
5. The method for producing a medicament for treating swine high fever according to claim 1, wherein the method comprises the steps of:
the 16-mesh sieve is used for sieving in the step S10.
6. The method for producing a medicament for treating swine high fever according to claim 1, wherein the method comprises the steps of:
the drying in step S10 is performed at a temperature of 60-70 degrees.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911231638.5A CN111135210A (en) | 2019-12-05 | 2019-12-05 | Production method of medicine for treating African swine fever |
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| CN201911231638.5A CN111135210A (en) | 2019-12-05 | 2019-12-05 | Production method of medicine for treating African swine fever |
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| CN111135210A true CN111135210A (en) | 2020-05-12 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113198009A (en) * | 2021-06-23 | 2021-08-03 | 长江大学 | Oral liquid for treating African swine fever and preparation method thereof |
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| CN106138226A (en) * | 2016-09-08 | 2016-11-23 | 河南弘羊生物科技有限公司 | A kind of Chinese medicine granules preventing and treating porcine hyperthermia and preparation method thereof |
| CN107137444A (en) * | 2017-05-31 | 2017-09-08 | 贵州省铜仁市万山区京军生态农牧发展有限公司 | It is a kind of to treat Chinese medicine composition of swine fever and preparation method thereof |
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- 2019-12-05 CN CN201911231638.5A patent/CN111135210A/en active Pending
Patent Citations (3)
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|---|---|---|---|---|
| CN103432215A (en) * | 2013-07-26 | 2013-12-11 | 清远容大生物工程有限公司 | Medicine used for preventing and treating high swine fever and preparation method thereof |
| CN106138226A (en) * | 2016-09-08 | 2016-11-23 | 河南弘羊生物科技有限公司 | A kind of Chinese medicine granules preventing and treating porcine hyperthermia and preparation method thereof |
| CN107137444A (en) * | 2017-05-31 | 2017-09-08 | 贵州省铜仁市万山区京军生态农牧发展有限公司 | It is a kind of to treat Chinese medicine composition of swine fever and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113198009A (en) * | 2021-06-23 | 2021-08-03 | 长江大学 | Oral liquid for treating African swine fever and preparation method thereof |
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Application publication date: 20200512 |