CN107137444A - It is a kind of to treat Chinese medicine composition of swine fever and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of swine fever and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a kind of Chinese medicine composition for treating swine fever and preparation method thereof, the Chinese medicine composition is by weight, by 3 25 parts of ginkgo leaf, 3 25 parts of Chinese blister beetle, 5 15 parts of radix bupleuri, 5 25 parts of balloonflower root, 13 parts of compositions of borneol, five kinds of Chinese medicine complements each other, Synergistic, the strongly fragrant poison of solution is played altogether, the effect of filling blood, for treating hog cholera effect highly significant, and Chinese medicine composition is prepared parenteral solution by the present invention, its is rapid-action, cure rate is up to more than 87%, it is very suitable for hog cholera, morbidity is unexpected, infect fast character control, and it is uneasy to recur, and it is without any side effects, use safety.
Description
Technical field：
The present invention relates to cultural technique field, and in particular to a kind of to treat Chinese medicine composition of swine fever and preparation method thereof.
Technical background：
Pork is the main meat food of China resident, and its property sweet-salty is put down, and contains abundant protein and fat, carbon water
The compositions such as compound, calcium, iron, phosphorus.With the critical period of our help-the-poor campaigns, pig industry is mainly got rich production as rural poverty
Industry, in recent years, the pig industry of China just towards intensive, large-scale development, but the disease of each boar annoyings raiser always, and
Cultivation confidence is defeated, wherein swine fever is to cause one of important diseases of pig industry economic loss.
Swine fever (Classical swine fever, CSF) is a kind of high degree in contact as caused by CSFV (CSFV)
Infectious disease, is commonly called as " rinderpest ", is a kind of Acute exposure sexually transmitted disease of pig, also known as hog cholera, its Clinical symptoms for morbidity it is anxious,
Hyperpyrexia is delaied to be denatured with minute blood vessel, causes the general hair property dot bleeding and splenic marginal infarct etc. of whole body；It is characterized in that, it is anxious
Property, change in septic, organa parenchymatosum's bleeding, necrosis and infarct；Chronic is in cellulosic necrotic enteritis, and often there is secondary wound in the later stage
Cold and pasteurellosis is secondary；This sick all ages and classes, sex, the pig of kind and wild boar are all susceptible, can occur throughout the year；Disease
Pig is major source of infection, sick pig excreta and secretion, sick dead pig and internal organs and corpse, the anxious blood for killing sick pig, meat, internal organ, useless
The feed of water, waste entrainment, drinking-water can all disseminate virus, and the propagation of swine fever is main by contact, through infection of digestive canal, in addition,
The sow that ill and low virulent strain infects can also produce weak pigle, stillborn foetus, mummy tire etc. through placenta vertical infection fetus.Pig
Pest are domestic animal common frdquently encountered diseases, because swine rearing amount is big, once morbidity, the sick pig death rate is high, infectiousness is strong, jeopardizes swinery, gives
Pig aquaculture brings heavy losses, is to threaten one of Infectious Diseases of pig industry.
Effective medicine is there is no at present, makes a definite diagnosis and takes measures in time in early days, to controlling and eliminating swine fever, reduce economy
Loss is significant.Traditional prevention and controls use to pig body and inject An Jibilin, quinine, pacify injection greatly, but it is chemistry
Medicine, does not meet the requirement of green non-pollution pig.
The content of the invention
The present invention, should in order to solve the above problems there is provided a kind of Chinese medicine composition for treating swine fever and preparation method thereof
Chinese medicine composition is made up of ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root, borneol, and the present invention is made into parenteral solution, and its is rapid-action,
It is used to treat hog cholera effect highly significant.
Specifically, a kind of Chinese medicine composition for treating swine fever, by weight, by 3-25 parts of ginkgo leaf, 3-25 parts of Chinese blister beetle,
5-15 parts of radix bupleuri, 5-25 parts of balloonflower root, 1-3 parts of compositions of borneol.
Further, a kind of Chinese medicine composition for treating swine fever, by weight, by 8-20 parts of ginkgo leaf, Chinese blister beetle 8-20
Part, 8-12 parts of radix bupleuri, 10-20 parts of balloonflower root, 1.5-2.5 parts of compositions of borneol.
Yet further, a kind of Chinese medicine composition for treating swine fever, by weight, by 14 parts of ginkgo leaf, 14 parts of Chinese blister beetle,
10 parts of radix bupleuri, 15 parts of balloonflower root, 2 parts of compositions of borneol.
Chinese medicine composition described above through pharmaceutically conventional extracting method it is extracted after with pharmaceutically acceptable
Various formulations are made in pharmaceutic adjuvant, and the present invention is preferably made parenteral solution.
Present invention also offers a kind of method that Chinese medicine composition prepares parenteral solution, its feature comprises the following steps：
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 1-3h is boiled in 2-4 times of decocting, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40-60min, and filtering, filtrate recycling ethanol is concentrated,
Dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 10-15min load ampoule bottle
In, every 10ml obtains Chinese medicine composition traditional Chinese medicine injection of the present invention.
Step (1) described above is to take ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root to crush, and crosses 40 mesh sieves, plus 3 times of decoctings are boiled
2h, filtering, filtrate concentration is dried, extract powder is made, the dregs of a decoction are standby.
The alcohol reflux that step (2) described above takes step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate is reclaimed
Ethanol, is concentrated, and is dried, is obtained medicinal powder.
Beneficial effects of the present invention are：
Ginkgo leaf：It is sweet, bitter, puckery, put down.The thoughts of returning home, lung channel.It can stimulate circulation, astringe the lung, relieving asthma, promoting blood circulation and removing blood stasis, analgesic；
Chinese blister beetle：Pungent, warm-natured, big poison enters large intestine, small intestine, liver and kidney channel.The effect of with malicious phagedenoma, powder medicine (Zhuyusan) knot is attacked.
Main ulcer；Scrofula；Stubborn dermatitis；Amenorrhea；Abdominal mass；Cancerous swelling.
Radix bupleuri：Meridian distribution of property and flavor, cold nature, bitter, pungent, return liver warp, gallbladder channel.Have soothing liver-gallbladder, dredge the work(of strongly fragrant, the scattered fire of gas solution
Effect.
Balloonflower root：With facilitaing lung, eliminating the phlegm, relieving sore-throat, apocenosis, relieving the five internal organs, fill blood, mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility the effect of.
Borneol：With logical all keys, stagnated fire is dissipated, screen improving eyesight, swelling and pain relieving is gone.
The present invention carries out prescription using ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root, the taste Chinese medicine of borneol 5, with the auxiliary phase of five tastes medicine phases
Into Synergistic is played solve strongly fragrant poison altogether, the effect of filling blood, for treating hog cholera effect highly significant, and of the invention by Chinese medicine
Composition prepares parenteral solution, and its is rapid-action, and cure rate is very suitable for hog cholera up to more than 87%, and morbidity is unexpected, infects fast spy
Control is levied, and it is uneasy to recur and without any side effects, use safety.
To further illustrate present disclosure and beneficial effect, the present invention has also listed following test example, it is intended to illustrate
The present invention, but never protection scope of the present invention is limited in any way.
1st, the recipe determination research of Chinese medicine composition of the present invention：
Experimental animal：The big white mouse (120 ± 4g) of Pass Test standard is taken, 200, is infected with CSFV (CSFV) big
White mouse, will appear from lassitude, and the blue color of auricle, the successful big white mouse of modeling takes out 140, is randomly divided into 7 groups, every group 20
Only, treated with following test group prescription drug, test result analysis are carried out after 4 days.
Test group 1：Using the parenteral solution being made up of ginkgo leaf 3g, Chinese blister beetle 3g, radix bupleuri 5g, balloonflower root 5g, borneol 1g.
Test group 2：Using the parenteral solution being made up of ginkgo leaf 8g, Chinese blister beetle 8g, radix bupleuri 8g, balloonflower root 10g, borneol 1.5g.
Test group 3：Using the parenteral solution being made up of ginkgo leaf 14g, Chinese blister beetle 14g, radix bupleuri 10g, balloonflower root 15g, borneol 2g.
Test group 4：Using the parenteral solution being made up of ginkgo leaf 20g, Chinese blister beetle 20g, radix bupleuri 12g, balloonflower root 20g, borneol 2.5g.
Test group 5：Using the parenteral solution being made up of ginkgo leaf 25g, Chinese blister beetle 25g, radix bupleuri 15g, balloonflower root 25g, borneol 3g groups.
Test group 6：Using the parenteral solution being made up of ginkgo leaf 14g, radix bupleuri 10g, balloonflower root 15g, borneol 2g.
Test group 7：Using the parenteral solution being made up of ginkgo leaf 14g, Chinese blister beetle 14g, balloonflower root 15g, borneol 2g.
Blank control group：Do not give any pharmaceutical intervention.
Equal conditions free water diet during experiment, test group 1-7 injects 5ml/kg to big white mouse daily, is united after 4 days
Count treatment, result of the test such as table 1 below：
| Test group | Number of animals | Cure number | Significant figure | Invalid number | Death toll |
| Test group 1 | 20 | 14 | 3 | 2 | 1 |
| Test group 2 | 20 | 14 | 3 | 2 | 1 |
| Test group 3 | 20 | 15 | 2 | 3 | 0 |
| Test group 4 | 20 | 15 | 3 | 2 | 0 |
| Test group 5 | 20 | 15 | 4 | 1 | 0 |
| Test group 6 | 20 | 8 | 3 | 4 | 5 |
| Test group 7 | 20 | 9 | 2 | 4 | 5 |
| Control group | 20 | 4 | 3 | 3 | 10 |
Result of the test shows, test group 1-7 to treatment big white mouse CSFV (CSFV) metainfective therapeutic effect with it is right
Compare according to group, be respectively provided with significant curative effect, and test group 1-5 is significantly better than test group 6-7 groups, therefore preferred therapeutic pig of the present invention
The Chinese medicine composition of pest is：3-25 parts of ginkgo leaf, 3-25 parts of Chinese blister beetle, 5-15 parts of radix bupleuri, 5-25 parts of balloonflower root, 1-3 parts of compositions of borneol；
More preferably it is made up of 8-20 parts of ginkgo leaf, 8-20 parts of Chinese blister beetle, 8-12 parts of radix bupleuri, 10-20 parts of balloonflower root, 1.5-2.5 parts of borneol；Most
Preferably it is made up of 14 parts of ginkgo leaf, 14 parts of Chinese blister beetle, 10 parts of radix bupleuri, 15 parts of balloonflower root, 2 parts of borneol.
2nd, the traditional Chinese medicine injection clinical tests for the treatment of swine fever produced by the present invention：
In the swine fever epidemic disease that in November, 2016 occurs, two groups are divided into 60 sick pigs and is treated, every group 30, examination
Test group：To wanting parenteral solution produced by the present invention to be treated, injection volume is 10ml/50kg, once a day, and successive administration 4 days is right
According to group 2：Injected and treated using florfenicol injection, successive administration 4 days carries out result of the test investigation, wherein, test group treatment
The effective percentage of swine fever sick pig is up to 86%, and control group treats the efficient up to 87% of swine fever sick pig.Illustrate in the obtained Chinese medicine of the present invention
Medicine parenteral solution has significant curative effect to hog cholera, suitable with florfenicol injection effect.
3rd, Chinese medicine composition Toxicity test of the present invention：
Take testing standard mouse (19 ± 1.2g) 40, be randomly divided into 2 groups, test group give injection it is produced by the present invention in
Drug composition parenteral solution, injection volume is 8ml/kg, is administered once daily, successive administration 7 days, control group：Any medicine is not awarded to do
In advance, two groups of equal conditions carry out drinking water diet, and as a result continuous 15 days observation mouse show, two groups of mouse survival behaviors, activity and
Drinking water diet, without significant difference, is normal.Illustrate safety non-toxic of the present invention, to pig without obvious injury.
With embodiment：
Embodiment 1：The preparation method of Chinese medicine composition of the present invention：
Formula：Ginkgo leaf 3g, Chinese blister beetle 3g, radix bupleuri 5g, balloonflower root 5g, borneol 1g；
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 1h is boiled in 2 times of decoctings, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 10min are fitted into ampoule bottle,
Every 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
Embodiment 2：The preparation method of Chinese medicine composition of the present invention：
Formula：Ginkgo leaf 8g, Chinese blister beetle 8g, radix bupleuri 8g, balloonflower root 10g, borneol 1.5g；
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 1h is boiled in 2 times of decoctings, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 10min are fitted into ampoule bottle,
Every 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
Embodiment 3：The preparation method of Chinese medicine composition of the present invention
Formula：Ginkgo leaf 14g, Chinese blister beetle 14g, radix bupleuri 10g, balloonflower root 15g, borneol 2g；
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 12min are fitted into ampoule bottle,
Every 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
Embodiment 4：The preparation method of Chinese medicine composition of the present invention
Formula：Ginkgo leaf 20g, Chinese blister beetle 20g, radix bupleuri 12g, balloonflower root 20g, borneol 2.5g；
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 12min are fitted into ampoule bottle,
Every 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
Test group 5：The preparation method of Chinese medicine composition of the present invention
Formula：Ginkgo leaf 25g, Chinese blister beetle 25g, radix bupleuri 15g, balloonflower root 25g, borneol 3g；
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 3h is boiled in 4 times of decoctings, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 60min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place
After cooling, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 15min are fitted into ampoule bottle,
Every 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
Claims (7)
1. a kind of Chinese medicine composition for treating swine fever, by weight, it is characterised in that：By 3-25 parts of ginkgo leaf, Chinese blister beetle 3-25
Part, 5-15 parts of radix bupleuri, 5-25 parts of balloonflower root, 1-3 parts of compositions of borneol.
2. the Chinese medicine composition for the treatment of swine fever according to claim 1, by weight, it is characterised in that：By ginkgo leaf
8-20 parts, 8-20 parts of Chinese blister beetle, 8-12 parts of radix bupleuri, 10-20 parts of balloonflower root, 1.5-2.5 parts of borneol composition.
3. the Chinese medicine composition for the treatment of swine fever according to claim 1 or 2, by weight, it is characterised in that：By ginkgo
14 parts of leaf, 14 parts of Chinese blister beetle, 10 parts of radix bupleuri, 15 parts of balloonflower root, 2 parts of compositions of borneol.
4. according to the Chinese medicine composition of any described treatment swine fevers of claim 1-3, it is characterised in that：Described Chinese traditional medicine composition
Thing through pharmaceutically conventional extracting method it is extracted after with pharmaceutically acceptable pharmaceutic adjuvant various formulations are made.
5. a kind of method that Chinese medicine composition prepares parenteral solution, it is characterised in that：Comprise the following steps：
(1) ginkgo leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, crosses 40 mesh sieves, plus 1-3h is boiled in 2-4 times of decocting, is filtered, filtrate concentration,
Dry, extract powder is made, the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40-60min, and filtering, filtrate recycling ethanol is concentrated, dried,
Obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds borneol dissolving, place cooling
Afterwards, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 10-15min are fitted into ampoule bottle, often
Branch 10ml, that is, obtain Chinese medicine composition traditional Chinese medicine injection of the present invention.
6. the method that Chinese medicine composition according to claim 4 prepares parenteral solution, it is characterised in that：Step (1) is to take silver
Apricot leaf, Chinese blister beetle, radix bupleuri, balloonflower root are crushed, and cross 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, are filtered, filtrate concentration, dry, extract powder is made,
The dregs of a decoction are standby.
7. the method that Chinese medicine composition according to claim 4 prepares parenteral solution, it is characterised in that：Described step (2)
It is that the alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 50min, filtering, filtrate recycling ethanol concentrates, dries, obtain medicine
Powder.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233493A (en) * | 2017-06-29 | 2017-10-10 | 贞丰县食源特种养殖有限公司 | It is a kind of to treat traditional Chinese medicine injection of checken pest and preparation method thereof |
| CN107320586A (en) * | 2017-07-31 | 2017-11-07 | 贞丰县龙山聚慧生态种养殖农民专业合作社 | It is a kind of to treat traditional Chinese medicine injection of hog cholera and preparation method thereof |
| CN111135210A (en) * | 2019-12-05 | 2020-05-12 | 广东容大生物股份有限公司 | Production method of medicine for treating African swine fever |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215009A (en) * | 2016-08-26 | 2016-12-14 | 任英明 | A kind of herbal medicine treating swine fever |
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| CN106215009A (en) * | 2016-08-26 | 2016-12-14 | 任英明 | A kind of herbal medicine treating swine fever |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233493A (en) * | 2017-06-29 | 2017-10-10 | 贞丰县食源特种养殖有限公司 | It is a kind of to treat traditional Chinese medicine injection of checken pest and preparation method thereof |
| CN107320586A (en) * | 2017-07-31 | 2017-11-07 | 贞丰县龙山聚慧生态种养殖农民专业合作社 | It is a kind of to treat traditional Chinese medicine injection of hog cholera and preparation method thereof |
| CN111135210A (en) * | 2019-12-05 | 2020-05-12 | 广东容大生物股份有限公司 | Production method of medicine for treating African swine fever |
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Application publication date: 20170908 |