CN107137485A - It is a kind of to treat traditional Chinese medicine injection of swine fever and preparation method thereof - Google Patents
It is a kind of to treat traditional Chinese medicine injection of swine fever and preparation method thereof Download PDFInfo
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a kind of traditional Chinese medicine injection for treating swine fever and preparation method thereof, the traditional Chinese medicine injection is by weight, by 3 25 parts of the fruit of Cherokee rose, 3 25 parts of awns beanstalk, 5 15 parts of radix bupleuri, 5 25 parts of Hedyotidis Diffusae, 13 parts of jamaicin is made, five kinds of Chinese medicine complements each other, Synergistic, the strongly fragrant poison of solution is played altogether, the effect of Ceftriaxone seasonal febrile diseases, for treating hog cholera effect highly significant, and using intravenous injection administering mode, its is rapid-action, cure rate is up to more than 83%, it is very suitable for hog cholera, morbidity is unexpected, infect fast character control, and it is uneasy to recur, and it is without any side effects, use safety.
Description
Technical field：
The present invention relates to cultural technique field, and in particular to a kind of to treat traditional Chinese medicine injection of swine fever and preparation method thereof.
Technical background：
Swine fever is also known as classic swine fever (Classical Swine Fever, CSF), is by CSFV (Classical
Swine Fever Virus, CSFV) contagious disease that causes pig to be characterized with hyperpyrexia, bleeding and high mortality.China is
Live pig produces consumes big country with pork, and feeding live pig amount accounts for global ratio close to 50%, and pork consumption accounts for domestic consumption of meat
60%.The animal epidemics such as swine fever are always the key factor for hindering China's pig industry to develop in a healthy way, the direct economy caused every year
Loss is up to 10,000,000,000 yuan.
Swine fever is a kind of Acute exposure sexually transmitted disease of pig, also known as hog cholera, and its Clinical symptoms is delaied for anxious, hyperpyrexia of falling ill
With minute blood vessel denaturation, cause the general hair property dot bleeding and splenic marginal infarct etc. of whole body；It is characterized in that, it is acute, in sepsis
Property change, organa parenchymatosum's bleeding, necrosis and infarct；Chronic is in cellulosic necrotic enteritis, and often there are paratyphoid and Pasteur in the later stage
Bacillosis is secondary；This sick all ages and classes, sex, the pig of kind and wild boar are all susceptible, can occur throughout the year；Sick pig is main
The infection sources, sick pig excreta and secretion, sick dead pig and internal organs and corpse, the anxious blood for killing sick pig, meat, internal organ, waste water, waste material are dirty
The feed of dye, drinking-water can all disseminate virus, and the propagation of swine fever is main by contact, through infection of digestive canal, in addition, ill and weak poison
The sow of strain infection can also produce weak pigle, stillborn foetus, mummy tire etc. through placenta vertical infection fetus.Swine fever is that domestic animal is normal
See frequently-occurring disease, because swine rearing amount is big, once morbidity, the sick pig death rate is high, infectiousness is strong, jeopardizes swinery, gives pig aquaculture band
Carry out heavy losses, be to threaten one of Infectious Diseases of pig industry.
Effective medicine is there is no at present, makes a definite diagnosis and takes measures in time in early days, to controlling and eliminating swine fever, reduce economy
Loss is significant.Traditional prevention and controls use to pig body and inject An Jibilin, quinine, pacify injection greatly, but it is chemistry
Medicine, does not meet the requirement of green non-pollution pig.
The content of the invention
The present invention, should in order to solve the above problems there is provided a kind of traditional Chinese medicine injection for treating swine fever and preparation method thereof
Traditional Chinese medicine injection is made up of the fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae, jamaicin, and the present invention is made into parenteral solution, its
Rapid-action, it is used to treat hog cholera effect highly significant.
Specifically, a kind of traditional Chinese medicine injection for treating swine fever, by weight, by 3-25 parts of the fruit of Cherokee rose, 3-25 parts of awns beanstalk,
5-15 parts of radix bupleuri, 5-25 parts of Hedyotidis Diffusae, 1-3 parts of compositions of jamaicin.
Further, a kind of traditional Chinese medicine injection for treating swine fever, by weight, by 8-20 parts of the fruit of Cherokee rose, awns beanstalk 8-20
Part, 8-12 parts of radix bupleuri, 10-20 parts of Hedyotidis Diffusae, 1.5-2.5 parts of compositions of jamaicin.
Yet further, a kind of traditional Chinese medicine injection for treating swine fever, by weight, by 14 parts of the fruit of Cherokee rose, 14 parts of awns beanstalk,
10 parts of radix bupleuri, 15 parts of Hedyotidis Diffusae, 2 parts of compositions of jamaicin.
Traditional Chinese medicine injection described above through pharmaceutically conventional extracting method it is extracted after with pharmaceutically acceptable
Various formulations are made in pharmaceutic adjuvant, and the present invention is preferably made parenteral solution.
Present invention also offers a kind of method that traditional Chinese medicine injection prepares parenteral solution, its feature comprises the following steps：
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 1-3h is boiled in 2-4 times of decocting, is filtered, filter
Liquid is concentrated, and is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40-60min, and filtering, filtrate recycling ethanol is concentrated,
Dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 10-15min load ampoule
In bottle, every 10ml obtains traditional Chinese medicine injection traditional Chinese medicine injection of the present invention.
Step (1) described above is to take the fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae to crush, and crosses 40 mesh sieves, plus 3 times of decoctings
2h is boiled, is filtered, filtrate concentration is dried, extract powder is made, the dregs of a decoction are standby.
The alcohol reflux that step (2) described above takes step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate is reclaimed
Ethanol, is concentrated, and is dried, is obtained medicinal powder.
Beneficial effects of the present invention are：
The present invention carries out prescription using the fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae, the taste Chinese medicine of jamaicin 5, with five kinds of Chinese medicine
Complement each other, Synergistic plays the strongly fragrant poison of solution, the effect of filling blood, for treating hog cholera effect highly significant, and the present invention altogether
Traditional Chinese medicine injection is prepared into parenteral solution, its is rapid-action, cure rate is very suitable for hog cholera up to more than 87%, and morbidity is unexpected, infects
Fast character control, and it is uneasy to recur and without any side effects, use safety.
To further illustrate present disclosure and beneficial effect, the present invention has also listed following test example, it is intended to illustrate
The present invention, but never protection scope of the present invention is limited in any way.
1st, the recipe determination research of traditional Chinese medicine injection of the present invention：
Experimental animal：The big white mouse (120 ± 4g) of Pass Test standard is taken, 200, is infected with CSFV (CSFV) big
White mouse, will appear from lassitude, and the blue color of auricle, the successful big white mouse of modeling takes out 140, is randomly divided into 7 groups, every group 20
Only, treated with following test group prescription drug, test result analysis are carried out after 4 days.
Test group 1：Using the parenteral solution being made up of fruit of Cherokee rose 3g, awns beanstalk 3g, radix bupleuri 5g, Hedyotidis Diffusae 5g, jamaicin 1g.
Test group 2：Using the injection being made up of fruit of Cherokee rose 8g, awns beanstalk 8g, radix bupleuri 8g, Hedyotidis Diffusae 10g, jamaicin 1.5g
Liquid.
Test group 3：Using the note being made up of fruit of Cherokee rose 14g, awns beanstalk 14g, radix bupleuri 10g, Hedyotidis Diffusae 15g, jamaicin 2g
Penetrate liquid.
Test group 4：It is made of by fruit of Cherokee rose 20g, awns beanstalk 20g, radix bupleuri 12g, Hedyotidis Diffusae 20g, jamaicin 2.5g
Parenteral solution.
Test group 5：It is made of by fruit of Cherokee rose 25g, awns beanstalk 25g, radix bupleuri 15g, Hedyotidis Diffusae 25g, jamaicin 3g groups
Parenteral solution.
Test group 6：Using the parenteral solution being made up of fruit of Cherokee rose 14g, radix bupleuri 10g, Hedyotidis Diffusae 15g, jamaicin 2g.
Test group 7：Using the parenteral solution being made up of fruit of Cherokee rose 14g, awns beanstalk 14g, Hedyotidis Diffusae 15g, jamaicin 2g.
Blank control group：Do not give any pharmaceutical intervention.
Equal conditions free water diet during experiment, test group 1-7 injects 5ml/kg to big white mouse daily, is united after 4 days
Count treatment, result of the test such as table 1 below：
Result of the test shows, test group 1-7 to treatment big white mouse CSFV (CSFV) metainfective therapeutic effect with it is right
Compare according to group, be respectively provided with significant curative effect, and test group 1-5 is significantly better than test group 6-7 groups, therefore preferred therapeutic pig of the present invention
The traditional Chinese medicine injection of pest is：3-25 parts of the fruit of Cherokee rose, 3-25 parts of awns beanstalk, 5-15 parts of radix bupleuri, 5-25 parts of Hedyotidis Diffusae, jamaicin 1-3
Part composition；More preferably by 8-20 parts of the fruit of Cherokee rose, 8-20 parts of awns beanstalk, 8-12 parts of radix bupleuri, 10-20 parts of Hedyotidis Diffusae, jamaicin
1.5-2.5 parts of compositions；Most preferably by 14 parts of the fruit of Cherokee rose, 14 parts of awns beanstalk, 10 parts of radix bupleuri, 15 parts of Hedyotidis Diffusae, 2 parts of groups of jamaicin
Into.
2nd, the traditional Chinese medicine injection clinical tests for the treatment of swine fever produced by the present invention：
In the swine fever epidemic disease that in November, 2016 occurs, two groups are divided into 60 sick pigs and is treated, every group 30, examination
Test group：To wanting parenteral solution produced by the present invention to be treated, injection volume is 10ml/50kg, once a day, and successive administration 4 days is right
According to group 2：Injected and treated using florfenicol injection, successive administration 4 days carries out result of the test investigation, wherein, test group treatment
The effective percentage of swine fever sick pig is up to 84%, and control group treats the efficient up to 86% of swine fever sick pig.Illustrate in the obtained Chinese medicine of the present invention
Medicine parenteral solution has significant curative effect to hog cholera, suitable with florfenicol injection effect.
3rd, traditional Chinese medicine injection Toxicity test of the present invention：
Take testing standard mouse (19 ± 1.2g) 40, be randomly divided into 2 groups, test group give injection it is produced by the present invention in
Medicine parenteral solution parenteral solution, injection volume is 8ml/kg, is administered once daily, successive administration 7 days, control group：Any medicine is not awarded to do
In advance, two groups of equal conditions carry out drinking water diet, and as a result continuous 15 days observation mouse show, two groups of mouse survival behaviors, activity and
Drinking water diet, without significant difference, is normal.Illustrate safety non-toxic of the present invention, to pig without obvious injury.
With embodiment：
Embodiment 1：The preparation method of traditional Chinese medicine injection of the present invention：
Formula：Fruit of Cherokee rose 3g, awns beanstalk 3g, radix bupleuri 5g, Hedyotidis Diffusae 5g, jamaicin 1g；
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 1h is boiled in 2 times of decoctings, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 10min load ampoule bottle
In, every 10ml obtains traditional Chinese medicine injection of the present invention.
Embodiment 2：The preparation method of traditional Chinese medicine injection of the present invention：
Formula：Fruit of Cherokee rose 8g, awns beanstalk 8g, radix bupleuri 8g, Hedyotidis Diffusae 10g, jamaicin 1.5g；
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 1h is boiled in 2 times of decoctings, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 40min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 10min load ampoule bottle
In, every 10ml obtains traditional Chinese medicine injection of the present invention.
Embodiment 3：The preparation method of traditional Chinese medicine injection of the present invention
Formula：Fruit of Cherokee rose 14g, awns beanstalk 14g, radix bupleuri 10g, Hedyotidis Diffusae 15g, jamaicin 2g；
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 12min load ampoule bottle
In, every 10ml obtains traditional Chinese medicine injection of the present invention.
Embodiment 4：The preparation method of traditional Chinese medicine injection of the present invention
Formula：Fruit of Cherokee rose 20g, awns beanstalk 20g, radix bupleuri 12g, Hedyotidis Diffusae 20g, jamaicin 2.5g；
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 50min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 12min load ampoule bottle
In, every 10ml obtains traditional Chinese medicine injection of the present invention.
Test group 5：The preparation method of traditional Chinese medicine injection of the present invention.
Formula：Fruit of Cherokee rose 25g, awns beanstalk 25g, radix bupleuri 15g, Hedyotidis Diffusae 25g, jamaicin 3g；
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 3h is boiled in 4 times of decoctings, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby.
(2) alcohol reflux for taking step (1) dregs of a decoction to add 45% extracts 60min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder.
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, put
Put after cooling, cross inorganic ceramic film filter, membrane aperture is 25nm, reclaim filtrate, 120 DEG C of sterilizing 15min load ampoule bottle
In, every 10ml obtains traditional Chinese medicine injection of the present invention.
Claims (7)
1. a kind of traditional Chinese medicine injection for treating swine fever, by weight, it is characterised in that：By 3-25 parts of the fruit of Cherokee rose, awns beanstalk 3-25
Part, 5-15 parts of radix bupleuri, 5-25 parts of Hedyotidis Diffusae, 1-3 parts of jamaicin are made.
2. the traditional Chinese medicine injection for the treatment of swine fever according to claim 1, by weight, it is characterised in that：By the fruit of Cherokee rose
8-20 parts, 8-20 parts of awns beanstalk, 8-12 parts of radix bupleuri, 10-20 parts of Hedyotidis Diffusae, 1.5-2.5 parts of jamaicin be made.
3. the traditional Chinese medicine injection for the treatment of swine fever according to claim 1 or 2, by weight, it is characterised in that：By golden cherry
14 parts of son, 14 parts of awns beanstalk, 10 parts of radix bupleuri, 15 parts of Hedyotidis Diffusae, 2 parts of jamaicin are made.
4. according to the traditional Chinese medicine injection of any described treatment swine fevers of claim 1-3, it is characterised in that：Described Chinese medicine injection
Liquid through pharmaceutically conventional extracting method it is extracted after with pharmaceutically acceptable pharmaceutic adjuvant various formulations are made.
5. a kind of method that traditional Chinese medicine injection prepares parenteral solution, it is characterised in that：Comprise the following steps：
(1) fruit of Cherokee rose, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, crosses 40 mesh sieves, plus 1-3h is boiled in 2-4 times of decocting, is filtered, filtrate is dense
Contracting, is dried, and extract powder is made, and the dregs of a decoction are standby；
(2) EtOH Sonicate ripple for taking step (1) dregs of a decoction to add 45% extracts 40-60min, and filtering, filtrate recycling ethanol is concentrated, done
It is dry, obtain medicinal powder；
(3) step (1) and step (2) plus 10 times of amount deionized water heating stirrings are dissolved, adds jamaicin dissolving, place cold
But after, inorganic ceramic film filter is crossed, membrane aperture is 25nm, reclaims filtrate, 120 DEG C of sterilizing 10-15min are fitted into ampoule bottle,
Every 10ml, that is, obtain traditional Chinese medicine injection of the present invention.
6. the method that traditional Chinese medicine injection according to claim 4 prepares parenteral solution, it is characterised in that：Step (1) is to take gold
Cherry, awns beanstalk, radix bupleuri, Hedyotidis Diffusae are crushed, and cross 40 mesh sieves, plus 2h is boiled in 3 times of decoctings, are filtered, filtrate concentration, dry, leaching is made
Cream powder, the dregs of a decoction are standby.
7. the method that traditional Chinese medicine injection according to claim 4 prepares parenteral solution, it is characterised in that：Described step (2)
It is that the EtOH Sonicate ripple for taking step (1) dregs of a decoction to add 45% extracts 50min, filtering, filtrate recycling ethanol concentrates, dries, obtain medicine
Powder.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233493A (en) * | 2017-06-29 | 2017-10-10 | 贞丰县食源特种养殖有限公司 | It is a kind of to treat traditional Chinese medicine injection of checken pest and preparation method thereof |
| CN107320586A (en) * | 2017-07-31 | 2017-11-07 | 贞丰县龙山聚慧生态种养殖农民专业合作社 | It is a kind of to treat traditional Chinese medicine injection of hog cholera and preparation method thereof |
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| CN104825769A (en) * | 2015-04-30 | 2015-08-12 | 新昌县大成生物科技有限公司 | Biological preparation for preventing swine fever |
| CN106215009A (en) * | 2016-08-26 | 2016-12-14 | 任英明 | A kind of herbal medicine treating swine fever |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233493A (en) * | 2017-06-29 | 2017-10-10 | 贞丰县食源特种养殖有限公司 | It is a kind of to treat traditional Chinese medicine injection of checken pest and preparation method thereof |
| CN107320586A (en) * | 2017-07-31 | 2017-11-07 | 贞丰县龙山聚慧生态种养殖农民专业合作社 | It is a kind of to treat traditional Chinese medicine injection of hog cholera and preparation method thereof |
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