CN105687830A - Medicine for preventing and treating qi and blood deficient type piroplasmosis of cattle - Google Patents

Medicine for preventing and treating qi and blood deficient type piroplasmosis of cattle Download PDF

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CN105687830A
CN105687830A CN201610091310.8A CN201610091310A CN105687830A CN 105687830 A CN105687830 A CN 105687830A CN 201610091310 A CN201610091310 A CN 201610091310A CN 105687830 A CN105687830 A CN 105687830A
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李佃场
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Abstract

The invention discloses a medicine for preventing and treating qi and blood deficient type piroplasmosis of cattle. The medicine comprises ficus esquiroliana, ficus formosana roots, salsifies, grewia biloba, berchemia sinica, akebia trifoliata koidz, rhizoma imperatae, poria, ramulus cinnamomi, malvastrum coromandelianum, solanum lyratum thunb, ramulus et folium picrasmae bark, gymbidium ensifolium roots, sargassum, verbena officinalis, gentianopsis paludosa, radix notoginseng, colla corii asini, sambucus adnata, herba lycopi, latouchea fokiensis, sinochasea trigyna, veronica serpyllifolia with insect galls, teucrium viscidum, sonchus arvensis, psychotria calocarpa kurz, rhodiola dumulosa and fructus mori. The medicine has the advantages that the medicine has functions of invigorating spleens, supplementing qi, diminishing swelling, removing dampness, replenishing blood and removing stasis, can be used for preventing and treating the piroplasmosis of the cattle and is low in cost, accordingly, the immunity of the cattle can be improved, recurrence can be prevented after the cattle is cured.

Description

A kind of medicine for preventing and treating weak type of qi and blood bovine piroplasmosis
Technical field
The present invention relates to veterinary drug technical field, particularly to a kind of medicine for preventing and treating weak type of qi and blood bovine piroplasmosis。
Background technology
Bovine piroplasmosis is again haemosoridiasis, is parasitized, by burnt worm, a kind of protozoacide caused in animal erythrocyte and reticuloendothelial cell。The burnt worm Master Home found in China's animal body in this section of BABEI BABEI this belong to and Taylor of Taylor section belongs to, it have been reported that Babesia bovis have 3 kinds: this Jiao worm of double; two bud BABEIs, Babesia bovis and this Jiao worm of avette BABEI。Cattle babesia taylor has 2 kinds: Theileria annulata and Theileria Sargenti。This burnt worm of BABEI all parasitizes in the erythrocyte of cattle, and after babesia taylor infected cattle, first invades in reticuloendothelial cell (being mainly lymphocyte, macrophage etc.), then invades in erythrocyte。The animal of burnt insect infection, except cattle and sheep, also has equus, dog pig etc., sometimes also can infect people, but the main object of primary disease harm is cattle and sheep。
Route of transmission: primary disease is propagated by sucking the blood of cattle by some Tickss of Ying Pi section, wherein the disseminator of this burnt worm of BABEI is mainly cattle Ticks, is secondly fan head tick, blood Ticks。The disseminator of babesia taylor is mainly glass eye Ticks, is secondly blood Ticks。So the growth and decline of the popular and local Ticks of primary disease, movable closely related, there are the multiple primary disease such as mountain area that a large amount of Ticks multiplies, forest zone, grassland。
Babesiasis has obvious seasonality, is generally the annual 5-9 month, and the 7-8 month is onset peak period。
The cattle Ticks of this burnt worm of main propagation BABEI is field parasitism Ticks, so this disease is multiple is born in the cattle that field is herded。The glass eye Ticks of main propagation babesia taylor is colony house parasitism Ticks, so this disease is multiple is born in drylot feeding cattle。
In Ticks Prevalent district, there is high heat, anemia, hemoglobinuria symptom in cattle, especially during spleen enlargement, can suspect for primary disease；But make a definite diagnosis and should make blood sheet, check that polypide just can determine that with after Ji's nurse Sa Albert'stain Albert。
Lab testing:
Babesiosis: 1～2 day (polypide rate of dyeing is high) after body temperature raises, takes ear vein blood smear, after dyeing by Rui Shi or Ji's Albert'stain Albert method, checks, it has been found that make a definite diagnosis after polypide in erythrocyte under oil mirror。Polypide resembles a pear in shape, oval etc., and length is many more than erythrocyte radius。
Babesia taylor is sick: body surface examination can find that volume Ticks is parasitic, and ill domestic animal high heat is delaied, and body temperature is up to 40-42 DEG C。Occurring body surface lymphadenectasis subsequently, especially mandibular lymph node and shoulder ALN enlargement are obvious, and palpation has pain。Heart beating accelerated breathing, loss of appetite。There is petechia or ecchymosis in the skin thin locations such as visual mucosa, perianal, breast, scrotum。Under jaw, front there is edema, become thin rapidly, anemia, the slight xanthochromia of visual mucosa。Grinding one's teeth in sleep occurs in ill cattle, sialorrhea, does not rise sleepingly, and what have also occurs gnawing soil, and diagnosis and treatment not in time, can be dead within 1-2 week, and acute case can be dead in 1-2d。
Western medical treatment is generally adopted insecticide Diminazene Aceturate or imidazophenylurea, and drug residue is big, is easily generated drug resistance, and easily repeatedly, people have certain adverse effect for body health after eating this type of Fructus Arctii to the state of an illness。
Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can strengthen cattle immunity, control difficulty in relapse after healing, with low cost。
The cards such as the traditional Chinese medical science is divided into heat to join the army point, deficient qi and blood, wherein deficient qi and blood disease sees that the thin hair of body is burnt, stands up and to transport step difficult, or sleeping ground does not rise, and urine color is pale red or dark red, jaundice, edema, and milk yield sharply declines, and sick cattle is weak rapidly, the many miscarriages of calver。
Summary of the invention
The technical problem to be solved is to be in that to provide a kind of medicine for preventing and treating weak type of qi and blood bovine piroplasmosis, adopt this medicine can overcome the defect of prior art Chinese medicine and western medicine, can invigorating the spleen and benefiting QI to the treatment of the cattle suffering from bovine piroplasmosis, detumescence dampness removing, enrich blood blood stasis dispelling, strengthening cattle immunity, control difficulty in relapse after healing, cost price is cheap。
In order to realize foregoing invention purpose, the invention provides a kind of medicine for preventing and treating weak type of qi and blood bovine piroplasmosis, described medicine includes following raw medicinal material: Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia, Radix Berchemiae Giraldianae, Fructus Akebiae, Rhizoma Imperatae, Poria, Ramulus Cinnamomi, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum, Herba Verbenae, gentianopsis paludosaMa, Radix Notoginseng, Colla Corii Asini, Herba Sambuci Adnatae, Herba Lycopi, Radix limonii sinensis, Sinochasea trigyna, Herba Veronicae Serpyllifoliae, Herba Chenopodii Hybridi, Herba Sonchi Arvensis, Herba Psychotriae Siamicae, Radix Rhodiolae Dumulosae and Fructus Mori。
In described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 6-13 weight portion, Radix Fici beecheyanae 7-14 weight portion, tragopogon pratensis l. 14-22 weight portion, bilobed grewia 10-20 weight portion, Radix Berchemiae Giraldianae 15-23 weight portion, Fructus Akebiae 17-26 weight portion, Rhizoma Imperatae 23-31 weight portion, Poria 20-35 weight portion, Ramulus Cinnamomi 18-25 weight portion, Herba Malvastri Coromandeliani 7-15 weight portion, Herba Solani Lyrati 2-5 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 2-4 weight portion, Radix Cymbidii Ensifolii 13-19 weight portion, Sargassum 14-27 weight portion, Herba Verbenae 9-17 weight portion, gentianopsis paludosaMa 4-11 weight portion, Radix Notoginseng 25-35 weight portion, Colla Corii Asini 22-30 weight portion, Herba Sambuci Adnatae 8-14 weight portion, Herba Lycopi's 10-17 weight portion, Radix limonii sinensis 13-20 weight portion, Sinochasea trigyna 18-29 weight portion, Herba Veronicae Serpyllifoliae 13-25 weight portion, Herba Chenopodii Hybridi 13-19 weight portion, Herba Sonchi Arvensis 20-28 weight portion, Herba Psychotriae Siamicae 18-27 weight portion, Radix Rhodiolae Dumulosae 8-15 weight portion and Fructus Mori 15-25 weight portion。
In described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 10 weight portion, Radix Fici beecheyanae 7 weight portion, tragopogon pratensis l. 22 weight portion, bilobed grewia 10 weight portion, Radix Berchemiae Giraldianae 23 weight portion, Fructus Akebiae 22 weight portion, Rhizoma Imperatae 28 weight portion, Poria 20 weight portion, Ramulus Cinnamomi 25 weight portion, Herba Malvastri Coromandeliani 7 weight portion, Herba Solani Lyrati 5 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 3 weight portion, Radix Cymbidii Ensifolii 13 weight portion, Sargassum 25 weight portion, Herba Verbenae 17 weight portion, gentianopsis paludosaMa 4 weight portion, Radix Notoginseng 35 weight portion, Colla Corii Asini 28 weight portion, Herba Sambuci Adnatae 13 weight portion, Herba Lycopi 17 weight portion, Radix limonii sinensis 13 weight portion, Sinochasea trigyna 25 weight portion, Herba Veronicae Serpyllifoliae 13 weight portion, Herba Chenopodii Hybridi 19 weight portion, Herba Sonchi Arvensis 28 weight portion, Herba Psychotriae Siamicae 18 weight portion, Radix Rhodiolae Dumulosae 10 weight portion and Fructus Mori 21 weight portion。
In described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 6 weight portion, Radix Fici beecheyanae 12 weight portion, tragopogon pratensis l. 14 weight portion, bilobed grewia 20 weight portion, Radix Berchemiae Giraldianae 21 weight portion, Fructus Akebiae 17 weight portion, Rhizoma Imperatae 31 weight portion, Poria 30 weight portion, Ramulus Cinnamomi 18 weight portion, Herba Malvastri Coromandeliani 15 weight portion, Herba Solani Lyrati 2 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 4 weight portion, Radix Cymbidii Ensifolii 19 weight portion, Sargassum 14 weight portion, Herba Verbenae 15 weight portion, gentianopsis paludosaMa 11 weight portion, Radix Notoginseng 30 weight portion, Colla Corii Asini 22 weight portion, Herba Sambuci Adnatae 14 weight portion, Herba Lycopi 15 weight portion, Radix limonii sinensis 16 weight portion, Sinochasea trigyna 18 weight portion, Herba Veronicae Serpyllifoliae 25 weight portion, Herba Chenopodii Hybridi 16 weight portion, Herba Sonchi Arvensis 20 weight portion, Herba Psychotriae Siamicae 27 weight portion, Radix Rhodiolae Dumulosae 8 weight portion and Fructus Mori 15 weight portion。
In described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 13 weight portion, Radix Fici beecheyanae 14 weight portion, tragopogon pratensis l. 18 weight portion, bilobed grewia 15 weight portion, Radix Berchemiae Giraldianae 15 weight portion, Fructus Akebiae 26 weight portion, Rhizoma Imperatae 23 weight portion, Poria 35 weight portion, Ramulus Cinnamomi 23 weight portion, Herba Malvastri Coromandeliani 11 weight portion, Herba Solani Lyrati 3 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 2 weight portion, Radix Cymbidii Ensifolii 16 weight portion, Sargassum 27 weight portion, Herba Verbenae 9 weight portion, gentianopsis paludosaMa 9 weight portion, Radix Notoginseng 25 weight portion, Colla Corii Asini 30 weight portion, Herba Sambuci Adnatae 8 weight portion, Herba Lycopi 10 weight portion, Radix limonii sinensis 20 weight portion, Sinochasea trigyna 29 weight portion, Herba Veronicae Serpyllifoliae 21 weight portion, Herba Chenopodii Hybridi 13 weight portion, Herba Sonchi Arvensis 23 weight portion, Herba Psychotriae Siamicae 24 weight portion, Radix Rhodiolae Dumulosae 12 weight portion and Fructus Mori 25 weight portion。
When the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 0.1～10 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 85%～95% of the quality 3～5 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24～36 hours when 5 DEG C～10 DEG C, adopt percolation with the speed slowly percolation of 1～2ml per minute, collect percolate, concentrate and dry, and pulverizing 40～60 minutes in super micron mill are put at this, the mixed powder that the micron particles of 0.1～10 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g～1.5g needle-use activated carbon, is sufficiently stirred for 30～50 minutes；Decarbonization filtering；With 0.22～0.24 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
When the dosage form of described medicine is powder, its preparation method comprises the following steps:
The first step, Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia and Radix Berchemiae Giraldianae are mixed in described ratio, dissolves with the ethanol that determining alcohol is 85%～95% of 3～5 times of the mixture quality relative to acquisition, extract after being heated to reflux 2～4 hours, filter, obtain the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 85%～95% of 1～2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1～2 hour, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with the deionized water of 5 times of resin column volumes or distilled water eluting, it is 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, dries and is ground into powder；
Second step, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum and Herba Verbenae are mixed in described ratio, add the ethanol of determining alcohol 85%～95% relative to 2～4 times of mixture quality obtained, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity is evaporated to 60 DEG C in 60 DEG C～70 DEG C when, relative density is the mastic of 1.20～1.23, and the mastic spray dryer after concentration is dried to powder；
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution relative to 2～4 times of mixture quality obtained, heating decoction 2～4 hours, filters；By filtering residue again with the water dissolution of 1～2 times of the mixture quality relative to acquisition, again heating decoction 1～2 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, dries and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 80～120 orders subsequently, the fine powder obtained is put into stirring in mixing and blending machine, namely obtains medicine。
When the dosage form of described medicine is powder, its preparation method can also be lower step:
Put into pulverizer to pulverize, Chinese medicine composition after pulverizing is loaded in decoction container, add suitable quantity of water and make its submergence medical material, after soaking 15 minutes, heating, to boiling 60 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；After filtrate cools down, adding relative to the determining alcohol of liquid weight 1 times after concentration is 85% ethanol, is sufficiently mixed uniformly, place overnight so that it is precipitation, after taking its supernatant liquid filtering next day, obtain filtrate, precipitate determining alcohol be 50% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, stand 1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；Paste placed in spray dryer dry, it is ensured that inlet temperature at 190 DEG C, leaving air temp 90 DEG C, be ground into 400 order powder subsequently, it is thus achieved that medicine。
The technical scheme that the embodiment of the present invention provides has the benefit that the medicine of the present invention, there is invigorating the spleen and benefiting QI, detumescence dampness removing, the function of blood stasis dispelling of enriching blood, at preventing and treating weak type of qi and blood bovine piroplasmosis, there is strengthening vital QI to eliminate pathogenic factors, strengthen cattle immunity shorter for the course for the treatment of, curative effect is better, has no drug resistance, drug residue free, control difficulty in relapse after healing, the advantage that cost price is cheap。
Detailed description of the invention
The invention provides a kind of medicine for preventing and treating weak type of qi and blood bovine piroplasmosis, including following raw medicinal material: Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia, Radix Berchemiae Giraldianae, Fructus Akebiae, Rhizoma Imperatae, Poria, Ramulus Cinnamomi, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum, Herba Verbenae, gentianopsis paludosaMa, Radix Notoginseng, Colla Corii Asini, Herba Sambuci Adnatae, Herba Lycopi, Radix limonii sinensis, Sinochasea trigyna, Herba Veronicae Serpyllifoliae, Herba Chenopodii Hybridi, Herba Sonchi Arvensis, Herba Psychotriae Siamicae, Radix Rhodiolae Dumulosae and Fructus Mori。
Wherein, Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia, Radix Berchemiae Giraldianae, Fructus Akebiae, Rhizoma Imperatae, Poria invigorating the spleen and benefiting QI；Ramulus Cinnamomi, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum, Herba Verbenae, gentianopsis paludosaMa detumescence dampness removing；Radix Notoginseng, Colla Corii Asini, Herba Sambuci Adnatae, Herba Lycopi, Radix limonii sinensis, Sinochasea trigyna are enriched blood blood stasis dispelling；Herba Veronicae Serpyllifoliae, Herba Chenopodii Hybridi promoting blood circulation and hemostasis；Herba Sonchi Arvensis, Herba Psychotriae Siamicae heat-clearing and toxic substances removing；Radix Rhodiolae Dumulosae, Fructus Mori YIN nourishing and the production of body fluid promoting。
Wherein, the pharmacology of each crude drug is as follows:
Ficus fulva Reinw.: another name the tiger palm, crow wind, amnesty mother-in-law tree, hair。Moraceae Ficus fulva Reinw., is used as medicine with root bark。Sweet, flat。Invigorating the spleen and benefiting QI, promoting blood circulation by removing wind。Curing mainly deficient qi and blood, uterine prolapse, proctoptosis, edema, rheumatic arthralgia, has loose bowels in loose stool。
Radix Fici beecheyanae: another name hair Fructus Fici Beecheyanae root (" Zhejiang conventional medical herbs among the people ")。Root for moraceae plants Fructus Fici Beecheyanae。Sweet；Pungent；Warm in nature。[return through] lung；Spleen；Kidney channel。Replenishing QI to invigorate the spleen；Promoting blood circulation to remove obstruction in the collateral；Expelling wind and removing dampness。Main overstrain is weak；Lack of appetite；Agalactia；Insufficiency of the spleen leucorrhea；Proctoptosis；Menoxenia；Wind syndrome of head pain；Traumatic injury；Rheumatic arthralgia。
Tragopogon pratensis l.: another name Tragopogon porrifolius L, green splendid achnatherum。Medical material Ji Yuan: for the Ye Hegen of feverfew Bulbus Allii leaf tragopogon pratensis l.。Sweet in the mouth；Light；Property is put down。Invigorating the spleen and benefiting QI。Main body after being ill is empty；Infantile malnutrition；Tinea capitis。
Bilobed grewia: another name Radix grewiae bilobae, sesame candy fruit, the moon pearlite layer, Grewia biloba G.Don。Tiliaceae Grewia Linn plant bilobed grewia is used as medicine with root or Herb。Acrid, sweet, warm。Invigorating the spleen and benefiting QI, treating spontaneous emission and leukorrhagia, expelling wind and removing dampness。For infantile malnutrition, insufficiency of the spleen chronic diarrhea, seminal emission, red collapse, leucorrhea, uterine prolapse, proctoptosis, rheumatic arthritis。
Radix Berchemiae Giraldianae: another name bullet bavin。Rhamnaceae hook fold plant Radix Berchemiae Giraldianae, is used as medicine with root, root bark and leaf。Sweet, micro-puckery, tepor。Spleen reinforcing dampness removing, relaxing muscles and tendons and activating QI and blood in the collateral, menstruction regulating and pain relieving。Root, root bark: rheumatic arthritis, icterohepatitis, gastric abscess, weakness of the spleen and stomach, inappetence, infantile malnutrition, dysmenorrhea；Traumatic injury, acute conjunctivitis, multiple furuncle and phyma are controlled in external。
Fructus Akebiae: another name] Yan Xuzi (numerous in the Meng), poultry storage is sub, take son (supplement to the Herbal), small wooden raft (" feeding habits book on Chinese herbal medicine "), covers son (" Japan hanako materia medica "), Caulis Akebiae sub (" the herbal speech that converges ")。For BENTONG section plant Caulis Akebiae, threeleaf akebia, white BENTONG fruit。Hiding micro-hardship, property is put down。Return liver, stomach, bladder warp。Dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis。Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor。
Rhizoma Imperatae: another name cogonsatintail, Rhizoma Imperatae, Rhizoma Imperatae, root of couch grass。This product is the dry rhizome of grass Herba Imperatae。Sweet, cold。[return through] returns lung, stomach, bladder warp。Cooling blood for hemostasis, clearing away heat and promoting diuresis。Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria；Acute nephritis edema。
Poria: sweet, light is flat。[return through] GUIXIN, lung, spleen, kidney channel。Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming。For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia。
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi。Acrid, sweet, warm。GUIXIN, lung, bladder warp。Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins。For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass。
Herba Malvastri Coromandeliani: call Coromadel Coast Falsemallow Herb, mountain Corchorus olitorius L., great Ye Hemerocallis citrina Baroni is violent, Prunus davidiana is young。Malvaceae Herba Malvastri Coromandeliani platymiscium Herba Malvastri Coromandeliani is with all herbal medicine。Sweet, light, cool。Clearing away heat-damp and promoting diuresis, detoxify dissipating blood stasis。For enteritis of catching a cold, dysentery, icterohepatitis, rheumatic arthritis；Traumatic injury, furuncle, carbuncle are controlled in external。
Herba Solani Lyrati: another name Herba Solani Lyrati, Pennisetum centrasiaticum Tzvel, hair Herba Senecionis Scandentis, hair Radix seu Caulis fici Martinii, Solanum lyratum Thunb., hair Xiucai, calabash grass, gold thread mossback。This product is that Solanaceae activity of Solanum Lyratum Thunb is used as medicine with herb or root。Hardship, is slightly cold。Enter liver, stomach warp。Heat-clearing and toxic substances removing, inducing diuresis and reducing edema, anticancer。Herb: for cold, fever, acute mastitis, malignant boil, jaundice due to damp-heat, ascites, leucorrhea, oedema due to nephritis；Carbuncle furuncle and phyma poison is controlled in external。Root: rheumatic arthralgia。
Ramulus et Folium Pcrasmae (Cortex Picrasmae): the logical skin of another name hardship, horse is heartbroken, suspension rod is numb, cabbageworm medicine, tiger fiber crops。Celastraceae celastraceae plants Celastrus angulatus, is used as medicine with root or root bark。Hardship, flat。Clearing away heat-damp and promoting diuresis, parasite killing。For impetigo, tinea capitis, fracture swells and ache, pudendal pruritus。
Radix Cymbidii Ensifolii: another name soil Radix Dipsaci (" continuous Textual Research "), Cymbidium ensifolium (L.) Sw. root (" five assorted ancient sacrificial utensils)), orchid root (" classifying herbal ")。Root for orchid sword-leaved cymbidium。Pungent, flat。Pleasant, and blood, dampness removing, detumescence。Control cough to spit blood, hemorrhoidal hamorrhage, metrorrhagia, gonorrhea, nebulousurine, leucorrhea, traumatic injury, carbuncle。
Sargassum: this product is the dry frond of Sargassaceae plant Sargassum or Sargassum fusiforme (Harv.) Setch。Bitter, salty, cold。Return liver, stomach, kidney channel。Hard masses softening and resolving, expectorant, diuretic。For goiter, scrofula, painful and swollen testis, phlegm retention edema。
Herba Verbenae: this product is the dry aerial parts of Verbenaceae Herba Verbenae。Hardship, cool。Return liver, spleen channel。Promoting blood circulation to remove blood stasis, preventing the attack (or recurrence) of malaria, removing toxic substances, inducing diuresis to remove edema。For lump in the abdomen, amenorrhea dysmenorrhea, malaria, sore throat, carbuncle, edema, pyretic stranguria。
Gentianopsis paludosaMa: another name Radix Gentianae, the raw Herba Gentianopsis Paludosae in natural pond。Medical material Ji Yuan: for the herb of gentianaceae plant gentianopsis paludosaMa。Bitter；Cold in nature。Clearing away heat-damp and promoting diuresis；Removing toxic substances。Main cold, fever；Hepatitis；Gallbladder thick soup is scorching；Pyelonephritis；Conjunctival congestion and swelling pain；Infantile diarrhea；Furuncle toxic swelling
Radix Notoginseng: hardship sweet, micro-, temperature。Return liver, stomach warp。Dissipating blood stasis stops blooding, subduing swelling and relieving pain。For spitting blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling。
Colla Corii Asini: sweet is flat。Return lung, liver, kidney channel。Enrich blood YIN nourishing, moisturize, hemostasis。For blood deficiency and yellow complexion, dizziness cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy。
Herba Sambuci Adnatae: another name showy reiolaena root-bark, big blood grass, Cortex torricelliae tiliifoliae, blood vessel grass (" Yunnan Chinese herbal medicine "), severe grass, Ramulus Sambuci Williamsii (" Chinese herbal medicine is commonly used in Tibet "), elm Gu Xingnabu (Tibetan name)。Herb and root for caprifoliaceae plant Red Hill flower。Xin Gan, temperature。Dispel the wind, diuretic, dissipating blood stasis, dredging collateral。Control acute and chronic nephritis, rheumatalgia, rubella pruritus, poliomyelitis sequela, sprain, fracture。
Herba Lycopi: another name lycopus lucidus, Rhizoma Lycopi Lucidi, Chinese artichoke, side obstruct Herba Lycopi。This product is the dry aerial parts of labiate hair leaf lycopus lucidus。Bitter, pungent, tepor。Return liver, spleen channel。Blood circulation promoting and blood stasis dispelling, line water detumescence。For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema。
Radix limonii sinensis: another name sea Radix Paeoniae Rubra, gloiopeltis are foretold, sea JINHUA, Chinese sealavender root (" Fujian Chinese herbal medicine ")。Root or herb for Plumbaginaceae plant Herba Limonii Gmelinii。Hardship, is slightly cold。Damp eliminating, heat clearing away, hemostasis。
Sinochasea trigyna: medical material Ji Yuan: for the herb of Melastomateae plants Sinochasea trigyna。Sweet in the mouth；Micro-hardship；Property is put down。Replenishing and activating blood。Main blood deficiency and yellow complexion；Metrorrhagia；Menoxenia
Herba Veronicae Serpyllifoliae: another name purslane speedwell Herba, foster leather and fur (" Shaanxi Chinese herbal medicine ")。For the little Herba veronicae fruit of Radix Scrophulariae kind of plant has the herb of insect gall。Sweet in the mouth；Bitter；Puckery；Property is put down。Return Liver Channel。Promoting blood circulation to remove blood stasis；Hemostasis；Removing toxic substances。Main traumatic injury；Menoxenia；Wound hemorrhage；Aphtha；Burn and scald。
Herba Chenopodii Hybridi: another name sowbane, assorted join Herba chenopodii (" will planted by northeast medicine "), assorted oak-leaved goosefeet, great Ye Chenopodium album (" Heilungkiang Chinese medicine "), anistree Chenopodium album (" Chinese herbal medicine handbook is commonly used in northeast ")。Herb for chenopod sowbane。
Herba Sonchi Arvensis: call Herba Sonchi Oleracei, Herba Patriniae [northern area], Herba Cirsii [Heilungkiang], Herba Sonchi Oleracei, take fiber crops dish。The herb of Compositae sonchus plant Herba Sonchi Arvensis。Hardship, antiperspirant。Heat-clearing and toxic substances removing, removing heat from blood dampness removing。For acute pharyngitis, acute bacillary dysentery, spit blood, hematuria, swelling and pain of hemorrhoid。
Herba Psychotriae Siamicae: call little contribution (" choosing of Yunnan Chinese herbal medicine ")。Herb for Maguireothamnus speciosus floral leaf Psychotria rubra (Lour.) Poir. wood。Bitter；Cool；Sweet。Return lung；Liver；Spleen；Large intestine channel。Improving eyesight；Heat clearing away；Dampness removing；Hemostasis。The red distending pain of argument；Pterygium；Gonorrhea；Icterohepatitis；Hematuria；Metrorrhagia
Radix Rhodiolae Dumulosae: another name Herba Pteridis Multifidae, FENGHUACAO, Sedum dumulosum。Crassulaceae Rhodida plant Rhodiola dumulosa, with all herbal medicine。Hardship sweet, micro-, puckery, temperature。Tonifying blood and regulating menstruation, yin nourishing。For menoxenia, deficiency of YIN hectic fever, have a dizzy spell, women's asthenia。
Fructus Mori: another name Mulberry reality, Shen, crow mulberry, civil and military mulberry real, black, Mulberry Fructus Jujubae, Fructus Mori, Sang Li, sorosis。Medical material Ji Yuan: for the fruit ear of moraceae plants Mulberry。Sweet；Acid；Cold in nature。Liver；Kidney channel。Nourishing YIN and benefiting blood；Promote the production of body fluid；Intestine moistening。Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence；Soreness of waist tinnitus；Early whitening of beard and hair；Insomnia and dreamful sleep；Tianjin wound is thirsty；Quench one's thirst；Dryness of the intestine constipation。
Hereinafter adopting embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this。
The toxicity test of the medicine of embodiment 1 present invention
Take Ficus fulva Reinw. 10g, Radix Fici beecheyanae 7g, tragopogon pratensis l. 22g, bilobed grewia 10g, Radix Berchemiae Giraldianae 23g, Fructus Akebiae 22g, Rhizoma Imperatae 28g, Poria 20g, Ramulus Cinnamomi 25g, Herba Malvastri Coromandeliani 7g, Herba Solani Lyrati 5g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 3g, Radix Cymbidii Ensifolii 13g, Sargassum 25g, Herba Verbenae 17g, gentianopsis paludosaMa 4g, Radix Notoginseng 35g, Colla Corii Asini 28g, Herba Sambuci Adnatae 13g, Herba Lycopi 17g, Radix limonii sinensis 13g, Sinochasea trigyna 25g, Herba Veronicae Serpyllifoliae 13g, Herba Chenopodii Hybridi 19g, Herba Sonchi Arvensis 28g, Herba Psychotriae Siamicae 18g, Radix Rhodiolae Dumulosae 10g and Fructus Mori 21g；After mix homogeneously, pulverizing, add the water of 1200g, decoct 2.5 hours, filter in the mixture after pulverizing, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and twice filtrate is mixed, is evaporated to the decoct that crude drug concentration is 3g/ml。
Taking ICR mice, body weight is at 25-30 gram, and by body weight random packet, often group 10, male and female half and half, oral administration solution is administered, and dosage is only 6.0ml/。Continuous Observation 20 days after administration, all mices of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction。White mouse oral cavity and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction。
Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable。
Take Ficus fulva Reinw. 6g, Radix Fici beecheyanae 12g, tragopogon pratensis l. 14g, bilobed grewia 20g, Radix Berchemiae Giraldianae 21g, Fructus Akebiae 17g, Rhizoma Imperatae 31g, Poria 30g, Ramulus Cinnamomi 18g, Herba Malvastri Coromandeliani 15g, Herba Solani Lyrati 2g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 4g, Radix Cymbidii Ensifolii 19g, Sargassum 14g, Herba Verbenae 15g, gentianopsis paludosaMa 11g, Radix Notoginseng 30g, Colla Corii Asini 22g, Herba Sambuci Adnatae 14g, Herba Lycopi 15g, Radix limonii sinensis 16g, Sinochasea trigyna 18g, Herba Veronicae Serpyllifoliae 25g, Herba Chenopodii Hybridi 16g, Herba Sonchi Arvensis 20g, Herba Psychotriae Siamicae 27g, Radix Rhodiolae Dumulosae 8g and Fructus Mori 15g；After mix homogeneously, pulverizing, add the water of 1200g, decoct 2.5 hours, filter in the mixture after pulverizing, the water adding 500g in filtering residue decocts 1.5 hours again, filters, and twice filtrate is mixed, is evaporated to the decoct that crude drug concentration is 3g/ml。
Taking ICR mice, body weight is at 25-30 gram, and by body weight random packet, often group 10, male and female half and half, oral administration solution is administered, and dosage is only 6.0ml/。Continuous Observation 20 days after administration, all mices of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction。White mouse oral cavity and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction。
Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable。
The medicine 1 of embodiment 2 present invention and preparation method
Take Ficus fulva Reinw. 10g, Radix Fici beecheyanae 7g, tragopogon pratensis l. 22g, bilobed grewia 10g, Radix Berchemiae Giraldianae 23g, Fructus Akebiae 22g, Rhizoma Imperatae 28g, Poria 20g, Ramulus Cinnamomi 25g, Herba Malvastri Coromandeliani 7g, Herba Solani Lyrati 5g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 3g, Radix Cymbidii Ensifolii 13g, Sargassum 25g, Herba Verbenae 17g, gentianopsis paludosaMa 4g, Radix Notoginseng 35g, Colla Corii Asini 28g, Herba Sambuci Adnatae 13g, Herba Lycopi 17g, Radix limonii sinensis 13g, Sinochasea trigyna 25g, Herba Veronicae Serpyllifoliae 13g, Herba Chenopodii Hybridi 19g, Herba Sonchi Arvensis 28g, Herba Psychotriae Siamicae 18g, Radix Rhodiolae Dumulosae 10g and Fructus Mori 21g;
When the dosage form of described medicine is injectable powder, its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, putting into the mixed powder that the micron particles being ground into 1 μm of volume average particle size in super micron mill and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
Second step, the mixed powder that the first step obtains adds the ethanol that determining alcohol is 95% of the quality 4 times relative to described mixed powder, stirring and dissolving obtains alcoholic solution, alcoholic solution is stood 24 hours when 5 DEG C, adopt percolation with the speed slowly percolation of 1ml per minute, collect percolate, concentrate and dry, and pulverizing 40 minutes in super micron mill are put at this, the mixed powder that the micron particles of 1 μm of volume average particle size of acquisition and particle diameter form less than the nano-scale particle of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%；
3rd step, takes the mixed powder 10g that second step obtains, and adds propylene glycol 30g, adds 200ml water for injection, and stirring makes it dissolve, and injects water to 1000ml further, adds 1g needle-use activated carbon, is sufficiently stirred for 30 minutes；Decarbonization filtering；With 0.22 μm of filtering with microporous membrane；Lyophilization obtains sterilized powder, subpackage embedding。
The medicine 2 of embodiment 3 present invention and preparation method
Take Ficus fulva Reinw. 6g, Radix Fici beecheyanae 12g, tragopogon pratensis l. 14g, bilobed grewia 20g, Radix Berchemiae Giraldianae 21g, Fructus Akebiae 17g, Rhizoma Imperatae 31g, Poria 30g, Ramulus Cinnamomi 18g, Herba Malvastri Coromandeliani 15g, Herba Solani Lyrati 2g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 4g, Radix Cymbidii Ensifolii 19g, Sargassum 14g, Herba Verbenae 15g, gentianopsis paludosaMa 11g, Radix Notoginseng 30g, Colla Corii Asini 22g, Herba Sambuci Adnatae 14g, Herba Lycopi 15g, Radix limonii sinensis 16g, Sinochasea trigyna 18g, Herba Veronicae Serpyllifoliae 25g, Herba Chenopodii Hybridi 16g, Herba Sonchi Arvensis 20g, Herba Psychotriae Siamicae 27g, Radix Rhodiolae Dumulosae 8g and Fructus Mori 15g；
When the dosage form of described pharmaceutical composition is powder, its preparation method comprises the following steps:
The first step, mixes Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia and Radix Berchemiae Giraldianae in described ratio, dissolves with the ethanol that determining alcohol is 85%% of 4 times of the mixture quality relative to acquisition, extracts after being heated to reflux 4 hours, filters, obtains the first filtrate；Filtering residue is dissolved with the ethanol of the determining alcohol 95% of 1 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 2 hours, filter, obtain the second filtrate；Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first with the deionized water of 5 times of resin column volumes or distilled water eluting, it is 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, dries and is ground into powder；
Second step, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum and Herba Verbenae are mixed in described ratio, add the ethanol of determining alcohol 95% relative to 2 times of mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity is evaporated to 60 DEG C in 60 DEG C when, relative density is the mastic of 1.20, and the mastic spray dryer after concentration is dried to powder；
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution relative to 3 times of mixture quality obtained, and heating decocts 4 hours, filters；By filtering residue again with the water dissolution of 2 times of the mixture quality relative to acquisition, again heating decoction 1 hour, filtration；Merging the filtrate of twice, concentrating under reduced pressure removes moisture, dries and is ground into powder；
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, it is screened into the fine powder of 120 orders subsequently, the fine powder obtained is put into stirring in mixing and blending machine, namely obtains medicine。
The medicine 3 of embodiment 4 present invention and preparation method
Take Ficus fulva Reinw. 13g, Radix Fici beecheyanae 14g, tragopogon pratensis l. 18g, bilobed grewia 15g, Radix Berchemiae Giraldianae 15g, Fructus Akebiae 26g, Rhizoma Imperatae 23g, Poria 35g, Ramulus Cinnamomi 23g, Herba Malvastri Coromandeliani 11g, Herba Solani Lyrati 3g, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 2g, Radix Cymbidii Ensifolii 16g, Sargassum 27g, Herba Verbenae 9g, gentianopsis paludosaMa 9g, Radix Notoginseng 25g, Colla Corii Asini 30g, Herba Sambuci Adnatae 8g, Herba Lycopi 10g, Radix limonii sinensis 20g, Sinochasea trigyna 29g, Herba Veronicae Serpyllifoliae 21g, Herba Chenopodii Hybridi 13g, Herba Sonchi Arvensis 23g, Herba Psychotriae Siamicae 24g, Radix Rhodiolae Dumulosae 12g and Fructus Mori 25g；
When the dosage form of described pharmaceutical composition is powder, its preparation method can also be lower step:
Put into pulverizer to pulverize, Chinese medicine composition after pulverizing is loaded in decoction container, add suitable quantity of water and make its submergence medical material, after soaking 15 minutes, heating, to boiling 60 minutes, separates fried liquid, medicinal residues again add water and carry out decocting 3 times, separate and collect each fried liquid, after filtering, take filtrate and abandon filtering residue；After filtrate cools down, adding relative to the determining alcohol of liquid weight 1 times after concentration is 85% ethanol, is sufficiently mixed uniformly, place overnight so that it is precipitation, after taking its supernatant liquid filtering next day, obtain filtrate, precipitate determining alcohol be 50% ethanol clean, collect washing liquid and also merge with filtrate, after decompression withdrawal ethanol, dislocation lets cool place, stand 1 hour, make precipitation complete, filter, filtrate low-temperature evaporation, it is thus achieved that paste；Paste placed in spray dryer dry, it is ensured that inlet temperature at 190 DEG C, leaving air temp 90 DEG C, be ground into 400 order powder subsequently, it is thus achieved that medicine。
Embodiment 5 clinical trial
(1) material prepares
Taking about 1 month uniform calf of body weight in 8 vaccaries of Heze City, Shandong Province 410, raise in strictly isolating without burnt worm when, March weans, and when feeding to 4 monthly age, random captures uniform 100 the healthy cattle of body weight, as prevention contrast test object；Random crawl uniform 300 the healthy cattle of body weight, as treatment contrast test object。
(2) prevention contrast test
The cattle as prevention contrast test object captured at random is randomly divided into 4 groups (matched group 1, matched group 2, embodiment group 1 and embodiment groups 2),
Wherein, embodiment group 1 uses the medicine 1 in embodiment 2 that cattle is injected, and every day 1 time, dose is 60mg/Kg, uses conventional feed to feed cattle；
Embodiment group 2 uses the medicine 2 in embodiment 3 to feed cattle after mixing with conventional feed, and medicine 2 is mixed in conventional feed according to the part by weight of 1:100；
Matched group 1 and matched group 2 use tradition cattle feedstuff to feed cattle respectively, after feeding 7 days, to matched group 1, embodiment group 1 and embodiment group 2, with the sickness rate and the mortality rate that carry the burnt cattle Ticks of worm, blood Ticks or glass eye Ticks artificial challenge's observed and recorded and respectively organize cattle, off-test。
Table 1 preventive effect synopsis
Group Sum Artificial challenge's number Sickness rate Death toll Mortality rate Protective rate
Embodiment group 1 25 25 0% 0 0% 100%
Embodiment group 2 25 25 0% 0 0% 100%
Matched group 1 25 25 100% 13 52% 48%
Matched group 2 25 0 0 0 0 100%
Data from table 1: bovine piroplasmosis is had obvious preventive effect by the medicine of the present invention。
(3) treatment contrast test:
The cattle 300 (medicine 1 treatment group, medicine 2 treatment group, medicine 2 treatment group, randomized controlled treatment group) as treatment contrast test object that will capture at random, every artificial challenge, choose weak type of qi and blood bovine piroplasmosis therein after clinical symptoms occurs and suffer from cattle 180, it is randomly divided into 4 groups to treat with different medicines
Wherein, medicine 1 treatment group selects the medicine 1 of embodiment 2；Every day 1 time, dose is 60mg/Kg, treats 1 day；
Medicine 2 treatment group selects the medicine 2 of embodiment 3, and every day 1 time, dose is 100g every day, treats 1 day；
Medicine 3 treatment group selects the medicine 3 of embodiment 4, and every day 1 time, dose is 100g every day, treats 1 day；
The every kg body weight 5mg of randomized controlled treatment group trypan blue, is made into 1 intravenous injection of 1% solution with 0.4% sodium chloride, and every day treats 1 day for 1 time;Result is as shown in table 2。
Table 2 therapeutic effect synopsis
Group Morbidity number Sickness rate Death toll Mortality rate Cure number Cure rate
Medicine 1 treatment group 45 100% 0 0% 30 100%
Medicine 2 treatment group 45 100% 0 0% 30 100%
Medicine 3 treatment group 45 100% 0 0% 30 100%
Western medicine group 45 100% 5 11% 40 89%
Data from table 2: the therapeutic effect of weak type of qi and blood bovine piroplasmosis is substantially better than western medicine group by the medicine of the present invention, reduce mortality rate, improve cure rate。
Model case
In July, 2012, Heze City, Shandong Province village has 6 monthly age calves to occur breathing and palpitating speed, muscular tremor, and body temperature reaches 43 DEG C, loss of appetite, spirit is depressed, it is difficult to stand up and take action, it is impossible to take a step, sometimes sleepingly not playing symptom and jaundice, edema occur with few days after, urine color is pale red。Gathering sick cattle venous blood, smear, Ji's nurse Sa dyes, microscopy。At the ears of an ox or cow vein place, first with iodine disinfection, then with after the de-iodine of ethanol of 75%, take ear vein blood 1, make blood smear, dry。Containing 2 polypides in result disease ORBC, and the hemocyte amount containing polypide is a lot, up to more than 40%。By clinical symptoms, cut open inspection pathological change, in conjunction with Epidemiological study and lab testing, finally really break as bovine piroplasmosis, Chinese medical discrimination weak type of qi and blood。First carrying out tick eradication, then adopt subcutaneous injection with the injectable powder injection powder injection of embodiment 2, dose is 60mg/Kg, injects 1 time, sick cattle recovery from illness。
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any amendment of making, equivalent replacement, improvement etc., should be included within protection scope of the present invention。

Claims (5)

1. the medicine being used for preventing and treating weak type of qi and blood bovine piroplasmosis, it is characterized in that, described medicine includes following raw medicinal material: Ficus fulva Reinw., Radix Fici beecheyanae, tragopogon pratensis l., bilobed grewia, Radix Berchemiae Giraldianae, Fructus Akebiae, Rhizoma Imperatae, Poria, Ramulus Cinnamomi, Herba Malvastri Coromandeliani, Herba Solani Lyrati, Ramulus et Folium Pcrasmae (Cortex Picrasmae), Radix Cymbidii Ensifolii, Sargassum, Herba Verbenae, gentianopsis paludosaMa, Radix Notoginseng, Colla Corii Asini, Herba Sambuci Adnatae, Herba Lycopi, Radix limonii sinensis, Sinochasea trigyna, Herba Veronicae Serpyllifoliae, Herba Chenopodii Hybridi, Herba Sonchi Arvensis, Herba Psychotriae Siamicae, Radix Rhodiolae Dumulosae and Fructus Mori。
2. the medicine for preventing and treating weak type of qi and blood bovine piroplasmosis according to claim 1, it is characterised in that in described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 6-13 weight portion, Radix Fici beecheyanae 7-14 weight portion, tragopogon pratensis l. 14-22 weight portion, bilobed grewia 10-20 weight portion, Radix Berchemiae Giraldianae 15-23 weight portion, Fructus Akebiae 17-26 weight portion, Rhizoma Imperatae 23-31 weight portion, Poria 20-35 weight portion, Ramulus Cinnamomi 18-25 weight portion, Herba Malvastri Coromandeliani 7-15 weight portion, Herba Solani Lyrati 2-5 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 2-4 weight portion, Radix Cymbidii Ensifolii 13-19 weight portion, Sargassum 14-27 weight portion, Herba Verbenae 9-17 weight portion, gentianopsis paludosaMa 4-11 weight portion, Radix Notoginseng 25-35 weight portion, Colla Corii Asini 22-30 weight portion, Herba Sambuci Adnatae 8-14 weight portion, Herba Lycopi's 10-17 weight portion, Radix limonii sinensis 13-20 weight portion, Sinochasea trigyna 18-29 weight portion, Herba Veronicae Serpyllifoliae 13-25 weight portion, Herba Chenopodii Hybridi 13-19 weight portion, Herba Sonchi Arvensis 20-28 weight portion, Herba Psychotriae Siamicae 18-27 weight portion, Radix Rhodiolae Dumulosae 8-15 weight portion and Fructus Mori 15-25 weight portion。
3. the medicine for preventing and treating weak type of qi and blood bovine piroplasmosis according to claim 1 and 2, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 10 weight portion, Radix Fici beecheyanae 7 weight portion, tragopogon pratensis l. 22 weight portion, bilobed grewia 10 weight portion, Radix Berchemiae Giraldianae 23 weight portion, Fructus Akebiae 22 weight portion, Rhizoma Imperatae 28 weight portion, Poria 20 weight portion, Ramulus Cinnamomi 25 weight portion, Herba Malvastri Coromandeliani 7 weight portion, Herba Solani Lyrati 5 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 3 weight portion, Radix Cymbidii Ensifolii 13 weight portion, Sargassum 25 weight portion, Herba Verbenae 17 weight portion, gentianopsis paludosaMa 4 weight portion, Radix Notoginseng 35 weight portion, Colla Corii Asini 28 weight portion, Herba Sambuci Adnatae 13 weight portion, Herba Lycopi 17 weight portion, Radix limonii sinensis 13 weight portion, Sinochasea trigyna 25 weight portion, Herba Veronicae Serpyllifoliae 13 weight portion, Herba Chenopodii Hybridi 19 weight portion, Herba Sonchi Arvensis 28 weight portion, Herba Psychotriae Siamicae 18 weight portion, Radix Rhodiolae Dumulosae 10 weight portion and Fructus Mori 21 weight portion。
4. according to the arbitrary described medicine for preventing and treating weak type of qi and blood bovine piroplasmosis of claim 1-3, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 6 weight portion, Radix Fici beecheyanae 12 weight portion, tragopogon pratensis l. 14 weight portion, bilobed grewia 20 weight portion, Radix Berchemiae Giraldianae 21 weight portion, Fructus Akebiae 17 weight portion, Rhizoma Imperatae 31 weight portion, Poria 30 weight portion, Ramulus Cinnamomi 18 weight portion, Herba Malvastri Coromandeliani 15 weight portion, Herba Solani Lyrati 2 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 4 weight portion, Radix Cymbidii Ensifolii 19 weight portion, Sargassum 14 weight portion, Herba Verbenae 15 weight portion, gentianopsis paludosaMa 11 weight portion, Radix Notoginseng 30 weight portion, Colla Corii Asini 22 weight portion, Herba Sambuci Adnatae 14 weight portion, Herba Lycopi 15 weight portion, Radix limonii sinensis 16 weight portion, Sinochasea trigyna 18 weight portion, Herba Veronicae Serpyllifoliae 25 weight portion, Herba Chenopodii Hybridi 16 weight portion, Herba Sonchi Arvensis 20 weight portion, Herba Psychotriae Siamicae 27 weight portion, Radix Rhodiolae Dumulosae 8 weight portion and Fructus Mori 15 weight portion。
5. according to the arbitrary described medicine for preventing and treating weak type of qi and blood bovine piroplasmosis of claim 1-4, it is characterized in that, in described medicine, the parts by weight of each raw medicinal material are: Ficus fulva Reinw. 13 weight portion, Radix Fici beecheyanae 14 weight portion, tragopogon pratensis l. 18 weight portion, bilobed grewia 15 weight portion, Radix Berchemiae Giraldianae 15 weight portion, Fructus Akebiae 26 weight portion, Rhizoma Imperatae 23 weight portion, Poria 35 weight portion, Ramulus Cinnamomi 23 weight portion, Herba Malvastri Coromandeliani 11 weight portion, Herba Solani Lyrati 3 weight portion, Ramulus et Folium Pcrasmae (Cortex Picrasmae) 2 weight portion, Radix Cymbidii Ensifolii 16 weight portion, Sargassum 27 weight portion, Herba Verbenae 9 weight portion, gentianopsis paludosaMa 9 weight portion, Radix Notoginseng 25 weight portion, Colla Corii Asini 30 weight portion, Herba Sambuci Adnatae 8 weight portion, Herba Lycopi 10 weight portion, Radix limonii sinensis 20 weight portion, Sinochasea trigyna 29 weight portion, Herba Veronicae Serpyllifoliae 21 weight portion, Herba Chenopodii Hybridi 13 weight portion, Herba Sonchi Arvensis 23 weight portion, Herba Psychotriae Siamicae 24 weight portion, Radix Rhodiolae Dumulosae 12 weight portion and Fructus Mori 25 weight portion。
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